{ "uniprot_canonical_ac": "D3ZAZ5-1", "uniprot_ac": "D3ZAZ5", "uniprot_id": "BCAR3_RAT", "mass": { "chemical_mass": 92477.0, "monoisotopic_mass": 92477.0 }, "refseq": { "ac": "NP_001101192", "name": "breast cancer anti-estrogen resistance protein 3 homolog", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101192" }, "gene_names": [ { "name": "Bcar3", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/D3ZAZ5", "id": "D3ZAZ5" }, { "name": "Bcar3", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101192", "id": "NP_001101192" } ], "protein_names": [ { "name": "Breast cancer anti-estrogen resistance protein 3 homolog", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "D3ZAZ5" }, { "name": "BCAR3 adapter protein, NSP family member", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "D3ZAZ5" }, { "name": "Novel SH2-containing protein 2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "D3ZAZ5" }, { "name": "SH2 domain-containing protein 3B", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "D3ZAZ5" }, { "name": "breast cancer anti-estrogen resistance 3; BCAR3, NSP family adaptor protein 3; novel SH2-containing protein 2; p130Cas-binding protein AND-34; SH2 domain-containing protein 3B; BCAR3 adapter protein, NSP family member", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101192", "id": "NP_001101192" }, { "name": "breast cancer anti-estrogen resistance protein 3 homolog", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101192", "id": "NP_001101192" }, { "name": "p130Cas-binding protein AND-34", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "D3ZAZ5" } ], "function": [ { "annotation": "Acts as an adapter protein downstream of several growth factor receptors to promote cell proliferation, migration, and redistribution of actin fibers (By similarity). Specifically involved in INS/insulin signaling pathway by mediating MAPK1/ERK2-MAPK3/ERK1 activation and DNA synthesis (PubMed:24216110). Promotes insulin-mediated membrane ruffling (PubMed:24216110). In response to vasoconstrictor peptide EDN1, involved in the activation of RAP1 downstream of PTK2B via interaction with phosphorylated BCAR1 (By similarity). Inhibits cell migration and invasion via regulation of TGFB-mediated matrix digestion, actin filament rearrangement, and inhibition of invadopodia activity (By similarity). May inhibit TGFB/SMAD signaling, via facilitating BCAR1 and SMAD2 and/or SMAD3 interaction (By similarity). Regulates EGF-induced DNA synthesis (By similarity). Required for the maintenance of ocular lens morphology and structural integrity, potentially via regulation of focal adhesion complex signaling (By similarity). Acts upstream of PTPRA to regulate the localization of BCAR1 and PTPRA to focal adhesions, via regulation of SRC-mediated phosphorylation of PTPRA (By similarity). Positively regulates integrin-induced tyrosine phosphorylation of BCAR1 (By similarity). Acts as a guanine nucleotide exchange factor (GEF) for small GTPases RALA, RAP1A and RRAS (By similarity). However, in a contrasting study, lacks GEF activity towards RAP1 (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "D3ZAZ5", "url": "https://www.uniprot.org/uniprot/D3ZAZ5#function" }, { "database": "UniProtKB", "id": "O75815", "url": "https://www.uniprot.org/uniprot/O75815#function" }, { "database": "PubMed", "id": "24216110", "url": "https://glygen.org/publication/PubMed/24216110" }, { "database": "UniProtKB", "id": "Q9QZK2", "url": "https://www.uniprot.org/uniprot/Q9QZK2#function" } ] }, { "annotation": "Study described a molecular complex of PTPalpha-BCAR3-Cas-Src; this complex forms in response to PTPalpha Tyr789 phosphorylation and mediates Cas localization to focal adhesions and Cas downstream signaling to promote cell migration", "evidence": [ { "database": "RefSeq", "id": "NP_001101192", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101192" }, { "database": "PubMed", "id": "22801373", "url": "https://glygen.org/publication/PubMed/22801373" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "D3ZAZ5", "url": "https://www.uniprot.org/uniprot/D3ZAZ5" } ], "common_name": "Rat" } ], "gene": [ { "name": "Bcar3", "url": "https://www.uniprot.org/uniprot/D3ZAZ5", "locus": { "chromosome": "2", "start_pos": 210638798, "end_pos": 210525260, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000013737", "url": "https://www.ensembl.org/id/ENSRNOG00000013737" } ] } } ], "crossref": [ { "id": "ENSRNOG00000013737", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000013737", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd10337", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd10337", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "310838", "url": "https://www.ncbi.nlm.nih.gov/gene/310838", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000980", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000980", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001895", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001895", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023578", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023578", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036860", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036860", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036964", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036964", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR044102", "url": "https://www.ebi.ac.uk/interpro/entry/IPR044102", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "rno:310838", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:310838", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "VLVWWQY", "url": "https://omabrowser.org/oma/group/VLVWWQY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "2953960at2759", "url": "http://www.orthodb.org/?query=2953960at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14247", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14247", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14247:SF10", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14247:SF10", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00017", "url": "http://pfam.xfam.org/family/PF00017", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF00617", "url": "http://pfam.xfam.org/family/PF00617", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_D3ZAZ5", "url": "http://purl.obolibrary.org/obo/PR_D3ZAZ5", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_001101192", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101192", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "1311688", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1311688", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "A0A8I5Y0X0", "url": "https://www.uniprot.org/uniprot/A0A8I5Y0X0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I5Y0X0-1", "url": "https://www.uniprot.org/uniprot/A0A8I5Y0X0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "D3ZAZ5", "url": "https://www.uniprot.org/uniprot/D3ZAZ5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "D3ZAZ5-1", "url": "https://www.uniprot.org/uniprot/D3ZAZ5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAGKFASLPRHMPVNHQFPLASSMDLLSSKSPLAEHRTEAYPDVSIHGTLPRKKKGPPPIRSCDSASHMGTLPHSKSPRQSSPLTQDLILEKPLPDWKGDSFAFRDPYLLDPTLEYVKFSKERHIMDRTPERLKKELEEELLLSSEDLRSHAWYHGRIPRQVSENLVQRDGDFLVRDSLSSPGNFVLTCQWKNLAQHFKINRTVLRLSEAYSRVQYQFEMESFDSIPGLVRCYVGNRRPISQQSGAIIFQPINRTVPLWCLEERYGTSPGRGREGSFAEGRPDVVKRLSLTTGGIQARDHSLPRGNLLRNKDKSGSQPACLDHVQDRKAATLKAHQSESHLPIGCKLPPQSPSVDTSPCPNSPVFRTGSEPTLSPALVRRFSSDARAGEALRGSDSQLCPKPPPKPCKVPFLKVPPSPSPWLNSEANYCELNPAFAVGCDRGAKLLSQALDSHEMLLTAKQNGASGPRNSGINYSILDGDDQGRHWDPLAVQTDEGQEDETKFVPPVMETVSSFRPNDFESKLLPPENKPLETAMLKHAKELFTNHDARVIAQHMLSVDCKVARILEVSEDMKRSMGVSSGLELITLPHGRQLRLDIIERHNTMAIGIAVDILGCTGTLENRAGTLNKIIQVAMELKDTMGDLYSFSAIMKALEMPQITRLEKTWTALRHHYTQTAILYEKQLKPFSKILHEGRESTYVPASSVSVPLLMPLVTLMERQAVTFEGTDMWEKNDESCEIMLSHLATARFMAEASESYRMNAERVLADFQPDEEMTEILKTEFQMRLLWGSKGAEVNQNERYDKFNQILTALSRKLEPPSGKQAEL", "length": 825, "header": "sp|D3ZAZ5-1|BCAR3_RAT Isoform 1 of Breast cancer anti-estrogen resistance protein 3 homolog OS=Rattus norvegicus OX=10116 GN=Bcar3 PE=1 SV=1 CANONICAL=D3ZAZ5-1" }, "isoforms": [ { "isoform_ac": "A0A8I5Y0X0-1", "url": "", "sequence": { "sequence": "MAAGKFASLPRHMPVNHQFPLASSMDLLSSKSPLAEHRTEAYPDVSIHGTLPRKKKGPPPIRSCDSASHSKSPRQSSPLTQDLILEKPLPDWKGDSFAFRDPYLLDPTLEYVKFSKERHIMDRTPERLKKELEEELLLSSEDLRSHAWYHGRIPRQVSENLVQRDGDFLVRDSLSSPGNFVLTCQWKNLAQHFKINRTVLRLSEAYSRVQYQFEMESFDSIPGLVRCYVGNRRPISQQSGAIIFQPINRTVPLWCLEERYGTSPGRGREGSFAEGRPDVVKRLSLTTGGIQARDHSLPRGNLLRNKDKSGSQPACLDHVQDRKAATLKAHQSESHLPIGCKLPPQSPSVDTSPCPNSPVFRTGSEPTLSPALVRRFSSDARAGEALRGSDSQLCPKPPPKPCKVPFLKVPPSPSPWLNSEANYCELNPAFAVGCDRGAKLLSQALDSHEMLLTAKQNGASGPRNSGINYSILDGDDQGRHWDPLAVQTDEGQEDETKFVPPVMETVSSFRPNDFESKLLPPENKPLETAMLKHAKELFTNHDARVIAQHMLSVDCKVARILEVSEDMKRSMGVSSGLELITLPHGRQLRLDIIERHNTMAIGIAVDILGCTGTLENRAGTLNKIIQVAMELKDTMGDLYSFSAIMKALEMPQITRLEKTWTALRHHYTQTAILYEKQLKPFSKILHEGRESTYVPASSVSVPLLMPLVTLMERQAVTFEGTDMWEKNDESCEIMLSHLATARFMAEASESYRMNAERVLADFQPDEEMTEILKTEFQMRLLWGSKGAEVNQNERYDKFNQILTALSRKLEPPSGKQAEL", "length": 819, "header": "tr|A0A8I5Y0X0-1|BCAR3_RAT Computationally mapped isoform of Breast cancer anti-estrogen resistance protein 3 homolog OS=Rattus norvegicus OX=10116 GN=Bcar3 PE=1 SV=1 CANONICAL=D3ZAZ5-1" }, "locus": { "chromosome": "2", "start_pos": 210638233, "end_pos": 210532766, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000107706.1", "url": "https://www.ensembl.org/id/ENSRNOT00000107706.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000076885.1", "url": "https://www.ensembl.org/id/ENSRNOP00000076885.1" } ] } }, { "isoform_ac": "D3ZAZ5-1", "url": "", "sequence": { "sequence": "MAAGKFASLPRHMPVNHQFPLASSMDLLSSKSPLAEHRTEAYPDVSIHGTLPRKKKGPPPIRSCDSASHMGTLPHSKSPRQSSPLTQDLILEKPLPDWKGDSFAFRDPYLLDPTLEYVKFSKERHIMDRTPERLKKELEEELLLSSEDLRSHAWYHGRIPRQVSENLVQRDGDFLVRDSLSSPGNFVLTCQWKNLAQHFKINRTVLRLSEAYSRVQYQFEMESFDSIPGLVRCYVGNRRPISQQSGAIIFQPINRTVPLWCLEERYGTSPGRGREGSFAEGRPDVVKRLSLTTGGIQARDHSLPRGNLLRNKDKSGSQPACLDHVQDRKAATLKAHQSESHLPIGCKLPPQSPSVDTSPCPNSPVFRTGSEPTLSPALVRRFSSDARAGEALRGSDSQLCPKPPPKPCKVPFLKVPPSPSPWLNSEANYCELNPAFAVGCDRGAKLLSQALDSHEMLLTAKQNGASGPRNSGINYSILDGDDQGRHWDPLAVQTDEGQEDETKFVPPVMETVSSFRPNDFESKLLPPENKPLETAMLKHAKELFTNHDARVIAQHMLSVDCKVARILEVSEDMKRSMGVSSGLELITLPHGRQLRLDIIERHNTMAIGIAVDILGCTGTLENRAGTLNKIIQVAMELKDTMGDLYSFSAIMKALEMPQITRLEKTWTALRHHYTQTAILYEKQLKPFSKILHEGRESTYVPASSVSVPLLMPLVTLMERQAVTFEGTDMWEKNDESCEIMLSHLATARFMAEASESYRMNAERVLADFQPDEEMTEILKTEFQMRLLWGSKGAEVNQNERYDKFNQILTALSRKLEPPSGKQAEL", "length": 825, "header": "sp|D3ZAZ5-1|BCAR3_RAT Isoform 1 of Breast cancer anti-estrogen resistance protein 3 homolog OS=Rattus norvegicus OX=10116 GN=Bcar3 PE=1 SV=1 CANONICAL=D3ZAZ5-1" }, "locus": { "chromosome": "2", "start_pos": 210638233, "end_pos": 210532766, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000065111", "url": "https://www.ensembl.org/id/ENSRNOT00000065111" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000062880", "url": "https://www.ensembl.org/id/ENSRNOP00000062880" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 182, "end_pos": 182, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "D3ZAZ5", "url": "https://www.uniprot.org/uniprot/D3ZAZ5" } ], "site_lbl": "Ser182" }, { "start_pos": 290, "end_pos": 290, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "D3ZAZ5", "url": "https://www.uniprot.org/uniprot/D3ZAZ5" } ], "site_lbl": "Ser290" }, { "start_pos": 32, "end_pos": 32, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "D3ZAZ5", "url": "https://www.uniprot.org/uniprot/D3ZAZ5" } ], "site_lbl": "Ser32" }, { "start_pos": 358, "end_pos": 358, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "D3ZAZ5", "url": "https://www.uniprot.org/uniprot/D3ZAZ5" } ], "site_lbl": "Ser358" }, { "start_pos": 363, "end_pos": 363, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "D3ZAZ5", "url": "https://www.uniprot.org/uniprot/D3ZAZ5" } ], "site_lbl": "Ser363" }, { "start_pos": 375, "end_pos": 375, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "D3ZAZ5", "url": "https://www.uniprot.org/uniprot/D3ZAZ5" } ], "site_lbl": "Ser375" }, { "start_pos": 471, "end_pos": 471, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "D3ZAZ5", "url": "https://www.uniprot.org/uniprot/D3ZAZ5" } ], "site_lbl": "Ser471" }, { "start_pos": 78, "end_pos": 78, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "D3ZAZ5", "url": "https://www.uniprot.org/uniprot/D3ZAZ5" } ], "site_lbl": "Ser78" }, { "start_pos": 83, "end_pos": 83, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "D3ZAZ5", "url": "https://www.uniprot.org/uniprot/D3ZAZ5" } ], "site_lbl": "Ser83" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.", "journal": "Nat. Commun.", "date": "2012", "authors": "Lundby A, Secher A, Lage K, Nordsborg NB, Dmytriyev A, Lundby C, Olsen JV", "evidence": [ { "database": "UniProtKB", "id": "D3ZAZ5", "url": "https://www.uniprot.org/uniprot/D3ZAZ5" } ], "reference": [ { "type": "PubMed", "id": "22673903", "url": "https://glygen.org/publication/PubMed/22673903" } ] }, { "title": "Protein tyrosine phosphatase alpha phosphotyrosyl-789 binds BCAR3 to position Cas for activation at integrin-mediated focal adhesions.", "journal": "Molecular and cellular biology", "date": "2012", "authors": "Sun G, Cheng SY, Chen M, Lim CJ, Pallen CJ", "evidence": [ { "database": "RefSeq", "id": "NP_001101192", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101192" } ], "reference": [ { "type": "PubMed", "id": "22801373", "url": "https://glygen.org/publication/PubMed/22801373" } ] }, { "title": "Functional roles of BCAR3 in the signaling pathways of insulin leading to DNA synthesis, membrane ruffling and GLUT4 translocation.", "journal": "Biochem. Biophys. Res. Commun.", "date": "2013", "authors": "Kim H.S., Kim J.H., van Agthoven T., Jhun B.H., Yi S.J., Oh M.J., Jeong Y.H.", "evidence": [ { "database": "UniProtKB", "id": "D3ZAZ5", "url": "https://www.uniprot.org/uniprot/D3ZAZ5" } ], "reference": [ { "type": "PubMed", "id": "24216110", "url": "https://glygen.org/publication/PubMed/24216110" } ] } ], "pathway": [ { "id": "rno:310838", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:310838", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "O75815-1", "protein_name": "Breast cancer anti-estrogen resistance protein 3", "gene_name": "BCAR3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAAGKFASLPRNMPVNHQFPLASSMDLLSSRSPLAEHRPDAYQDVSIHGTLPRKKKGPPPIRSCDDFSHMGTLPHSKSPRQNSPVTQDGIQESPWQDRHGETFTFRDPHLLDPTVEYVKFSKERHIMDRTPEKLKKELEEELLLSSEDLRSHAWYHGRIPRQVSENLVQRDGDFLVRDSLSSPGNFVLTCQWKNLAQHFKINRTVLRLSEAYSRVQYQFEMESFDSIPGLVRCYVGNRRPISQQSGAIIFQPINRTVPLRCLEEHYGTSPGQAREGSLTKGRPDVAKRLSLTMGGVQAREQNLPRGNLLRNKEKSGSQPACLDHMQDRRALSLKAHQSESYLPIGCKLPPQSSGVDTSPCPNSPVFRTGSEPALSPAVVRRVSSDARAGEALRGSDSQLCPKPPPKPCKVPFLKVPSSPSAWLNSEANYCELNPAFATGCGRGAKLPSCAQGSHTELLTAKQNEAPGPRNSGVNYLILDDDDRERPWEPAAAQMEKGQWDKGEFVTPLLETVSSFRPNEFESKFLPPENKPLETAMLKRAKELFTNNDPKVIAQHVLSMDCRVARILGVSEEMRRNMGVSSGLELITLPHGHQLRLDIIERHNTMAIGIAVDILGCTGTLEDRAATLSKIIQVAVELKDSMGDLYSFSALMKALEMPQITRLEKTWTALRHQYTQTAILYEKQLKPFSKLLHEGRESTCVPPNNVSVPLLMPLVTLMERQAVTFEGTDMWEKNDQSCEIMLNHLATARFMAEAADSYRMNAERILAGFQPDEEMNEICKTEFQMRLLWGSKGAQVNQTERYEKFNQILTALSRKLEPPPVKQAEL", "length": 825 }, "evidence": [ { "id": "45229533", "url": "http://www.informatics.jax.org/homology/45229533", "database": "MGI" }, { "id": "D3ZAZ5", "url": "https://omabrowser.org/oma/group/D3ZAZ5/", "database": "OMA" } ], "common_name": "Human" }, { "uniprot_canonical_ac": "Q9QZK2-1", "protein_name": "Breast cancer anti-estrogen resistance protein 3 homolog", "gene_name": "Bcar3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAAGKFASLPRNMPVNHQFPLASSMDLLSSKSPLAERRTDAYQDVSIHGTLPRKKKGPPSIRSCDNAGHSKSPRQSSPLTQDIIQENPLQDRKGENFIFRDPYLLDPTLEYVKFSKERHIMDRTPERLKKELEEELLLSSEDLRSHAWYHGRIPRQVSENLVQRDGDFLVRDSLSSPGNFVLTCQWKNLAQHFKINRTVLRLSEAYSRVQYQFEMESFDSIPGLVRCYVGNRRPISQQSGAIIFQPINRTVPLWCLEERYGTSPGRGREGSLAEGRPDVVKRLSLTTGSSIQAREHSLPRGNLLRNKEKSGSQPACLDHVQDRKALTLKAHQSESHLPIGCKLPPQSPSMDTSPCPSSPVFRTGSEPTLSPALVRRFSSDARTGEALRGSDSQLCPKPPPKPCKVPFLKTPPSPSPWLTSEANYCELNPAFAVGCDRGAKLPMQAHDSHEMLLTAKQNGPSGPRNSGINYMILDGDDQARHWDPLAVQTDEGQEDKTKFVPPLMETVSSFRPNDFESKLLPPENKPLETAMLKHAKELFTNHDARVIAQHMLSVDCKVARILEVSEDRKRSMGVSSGLELITLPHGRQLRLDIIERHNTMAIGIAVDILGCTGTLENRAGTLNKIIQVAVELKDAMGDLYAFSAIMKALEMPQITRLEKTWTALRHHYTQTAILYEKQLKPFSKILHEGRESTYVPASNVSVPLLMPLVTLMERQAVTFEGTDMWENNDESCEILLNHLATARFMAEASESYRMNAERILADFQPDEEMTEILRTEFQMRLLWGSKGAEVNQNERYDKFNQILTALSRKLEPPSGKQAEL", "length": 820 }, "evidence": [ { "id": "45229533", "url": "http://www.informatics.jax.org/homology/45229533", "database": "MGI" }, { "id": "D3ZAZ5", "url": "https://omabrowser.org/oma/group/D3ZAZ5/", "database": "OMA" } ], "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "phosphotyrosine residue binding", "id": "GO:0001784", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001784", "evidence": [ { "database": "UniProtKB", "id": "D3ZAZ5", "url": "https://www.uniprot.org/uniprot/D3ZAZ5" } ], "pmid": "" }, { "name": "guanyl-nucleotide exchange factor activity", "id": "GO:0005085", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005085", "evidence": [ { "database": "UniProtKB", "id": "D3ZAZ5", "url": "https://www.uniprot.org/uniprot/D3ZAZ5" } ], "pmid": "" }, { "name": "kinase binding", "id": "GO:0019900", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019900", "evidence": [ { "database": "UniProtKB", "id": "D3ZAZ5", "url": "https://www.uniprot.org/uniprot/D3ZAZ5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 9, "go_terms": [ { "name": "small GTPase mediated signal transduction", "id": "GO:0007264", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007264", "evidence": [ { "database": "UniProtKB", "id": "D3ZAZ5", "url": "https://www.uniprot.org/uniprot/D3ZAZ5" } ], "pmid": "" }, { "name": "endothelin receptor signaling pathway", "id": "GO:0086100", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0086100", "evidence": [ { "database": "UniProtKB", "id": "D3ZAZ5", "url": "https://www.uniprot.org/uniprot/D3ZAZ5" } ], "pmid": "" }, { "name": "positive regulation of peptidyl-serine phosphorylation", "id": "GO:0033138", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033138", "evidence": [ { "database": "UniProtKB", "id": "D3ZAZ5", "url": "https://www.uniprot.org/uniprot/D3ZAZ5" } ], "pmid": "" }, { "name": "positive regulation of MAPK cascade", "id": "GO:0043410", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043410", "evidence": [ { "database": "UniProtKB", "id": "D3ZAZ5", "url": "https://www.uniprot.org/uniprot/D3ZAZ5" } ], "pmid": "" }, { "name": "positive regulation of GTPase activity", "id": "GO:0043547", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043547", "evidence": [ { "database": "UniProtKB", "id": "D3ZAZ5", "url": "https://www.uniprot.org/uniprot/D3ZAZ5" } ], "pmid": "" }, { "name": "positive regulation of epidermal growth factor receptor signaling pathway", "id": "GO:0045742", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045742", "evidence": [ { "database": "UniProtKB", "id": "D3ZAZ5", "url": "https://www.uniprot.org/uniprot/D3ZAZ5" } ], "pmid": "" }, { "name": "insulin receptor signaling pathway", "id": "GO:0008286", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008286", "evidence": [ { "database": "UniProtKB", "id": "D3ZAZ5", "url": "https://www.uniprot.org/uniprot/D3ZAZ5" } ], "pmid": "" }, { "name": "positive regulation of DNA replication", "id": "GO:0045740", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045740", "evidence": [ { "database": "UniProtKB", "id": "D3ZAZ5", "url": "https://www.uniprot.org/uniprot/D3ZAZ5" } ], "pmid": "" }, { "name": "lens morphogenesis in camera-type eye", "id": "GO:0002089", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002089", "evidence": [ { "database": "UniProtKB", "id": "D3ZAZ5", "url": "https://www.uniprot.org/uniprot/D3ZAZ5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "D3ZAZ5", "url": "https://www.uniprot.org/uniprot/D3ZAZ5" } ], "pmid": "" }, { "name": "focal adhesion", "id": "GO:0005925", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005925", "evidence": [ { "database": "UniProtKB", "id": "D3ZAZ5", "url": "https://www.uniprot.org/uniprot/D3ZAZ5" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "D3ZAZ5", "url": "https://www.uniprot.org/uniprot/D3ZAZ5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 202, "end_pos": 204, "annotation": "n_glycosylation_sequon" }, { "start_pos": 254, "end_pos": 256, "annotation": "n_glycosylation_sequon" }, { "start_pos": 474, "end_pos": 476, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [ { "annotation": "Phosphorylated on tyrosine residues.", "evidence": [ { "database": "UniProtKB", "id": "D3ZAZ5", "url": "https://www.uniprot.org/uniprot/D3ZAZ5" }, { "database": "PubMed", "id": "Q9QZK2", "url": "https://glygen.org/publication/PubMed/Q9QZK2" } ] } ], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], 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