{ "uniprot_canonical_ac": "D3Z8Q6-1", "uniprot_ac": "D3Z8Q6", "uniprot_id": "D3Z8Q6_RAT", "mass": { "chemical_mass": 140762.0, "monoisotopic_mass": 140762.0 }, "refseq": { "ac": "NP_001099554", "name": "poly [ADP-ribose] polymerase tankyrase-1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099554" }, "gene_names": [ { "name": "Tnks", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/D3Z8Q6", "id": "D3Z8Q6" }, { "name": "Tnks", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099554", "id": "NP_001099554" } ], "protein_names": [ { "name": "Poly [ADP-ribose] polymerase", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "D3Z8Q6" }, { "name": "2.4.2.-", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "D3Z8Q6" }, { "name": "PARP", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "D3Z8Q6" }, { "name": "poly [ADP-ribose] polymerase tankyrase-1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099554", "id": "NP_001099554" }, { "name": "tankyrase-1; tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099554", "id": "NP_001099554" } ], "function": [ { "annotation": "Studied role of tankyrase and effect of tankyrase inhibitor XAV939 on corpus luteum development , luteal function, and Wnt/beta-catenin signaling in gonadotropin-treated prepubertal rats.", "evidence": [ { "database": "RefSeq", "id": "NP_001099554", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099554" }, { "database": "PubMed", "id": "28628258", "url": "https://glygen.org/publication/PubMed/28628258" } ] }, { "annotation": "Tankyrase-mediated PARsylation is promoted by nutritional energy stimulated NAD+ in insulinoma cells Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001099554", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099554" }, { "database": "PubMed", "id": "25876076", "url": "https://glygen.org/publication/PubMed/25876076" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "D3Z8Q6", "url": "https://www.uniprot.org/uniprot/D3Z8Q6" } ], "common_name": "Rat" } ], "gene": [ { "name": "Tnks", "url": "https://www.uniprot.org/uniprot/D3Z8Q6", "locus": { "chromosome": "16", "start_pos": 57366260, "end_pos": 57225094, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000011625", "url": "https://www.ensembl.org/id/ENSRNOG00000011625" } ] } } ], "crossref": [ { "id": "ENSRNOG00000011625", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000011625", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd01438", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01438", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd09524", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd09524", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "290794", "url": "https://www.ncbi.nlm.nih.gov/gene/290794", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001660", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001660", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012317", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012317", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013761", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013761", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036770", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036770", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "rno:290794", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:290794", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CPDGKRK", "url": "https://omabrowser.org/oma/group/CPDGKRK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "5477658at2759", "url": "http://www.orthodb.org/?query=5477658at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24189", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24189", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24189:SF66", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24189:SF66", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00023", "url": "http://pfam.xfam.org/family/PF00023", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF00644", "url": "http://pfam.xfam.org/family/PF00644", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF07647", "url": "http://pfam.xfam.org/family/PF07647", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF12796", "url": "http://pfam.xfam.org/family/PF12796", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF13606", "url": "http://pfam.xfam.org/family/PF13606", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF13637", "url": "http://pfam.xfam.org/family/PF13637", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF13857", "url": "http://pfam.xfam.org/family/PF13857", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-201681", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-201681", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-4641257", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-4641257", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-5689880", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5689880", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-8948751", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8948751", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_001099554", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099554", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "1308784", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1308784", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "A0A8I5YBL7", "url": "https://www.uniprot.org/uniprot/A0A8I5YBL7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I5YBL7-1", "url": "https://www.uniprot.org/uniprot/A0A8I5YBL7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "D3Z8Q6", "url": "https://www.uniprot.org/uniprot/D3Z8Q6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "D3Z8Q6-1", "url": "https://www.uniprot.org/uniprot/D3Z8Q6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAASRRSQHHHHHHQQQLQPAPGASAPPPPPPPPLSPGLAPGPTPASPTAGGLAPFASPRHGLALPEGDGSRDPPDRPRSPDPVDGAVCTVAATAAAPAASAAVGVAPSPAGGGGNNSASSTSSPTSSSSSSPSSPGSSIAESPEAAGVGSTATLGPGAAGLGPGVPAVSGALRELLEACRNGDVSRVKRLVDAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVASLHPKRKQVAELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDSLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFTAAQMGNEAVQQILSESTPIRTSDVDYRLLEASKAGDLETVKQLCSPQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLVKEGDTDIQDLLRGDAALLDAAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLERGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLATADDIRALLIDAMPPEALPTCFKPQATVVSASLISPASTPSCLSAASSIDNLTGPLAELAVGGASNAGDGAAGAERKEGEVAGLDMNISQFLKSLGLEHLRDIFETEQITLDVLADMGHEELKEIGINAYGHRHKLIKGVERLLGGQQGTNPYLTFHCVNQGTILLDLAPEDKEYQSVEEEMQSTIREHRDGGNAGGIFNRYNVIRIQKVVNKKLRERFCHRQKEVSEENHNHHNERMLFHGSPFINAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPTHKDRSCYVCHRQMLFCRVTLGKSFLQFSTMKMAHAPPGHHSVIGRPSVNGLAYAEYVIYRGEQAYPEYLITYQIMKPEAPSQTATAAEQKT", "length": 1317, "header": "tr|D3Z8Q6-1|D3Z8Q6_RAT Isoform 1 of Poly [ADP-ribose] polymerase OS=Rattus norvegicus OX=10116 GN=Tnks PE=1 SV=1 CANONICAL=D3Z8Q6-1" }, "isoforms": [ { "isoform_ac": "A0A8I5YBL7-1", "url": "", "sequence": { "sequence": "MAASRRSQHHHHHHQQQLQPAPGASAPPPPPPPPLSPGLAPGPTPASPTAGGLAPFASPRHGLALPEGDGSRDPPDRPRSPDPVDGAVCTVAATAAAPAASAAVGVAPSPAGGGGNNSASSTSSPTSSSSSSPSSPGSSIAESPEAAGVGSTATLGPGAAGLGPGVPAVSGALRELLEACRNGDVSRVKRLVDAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTEINLLPFYRSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVASLHPKRKQVAELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDSLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFTAAQMGNEAVQQILSESTPIRTSDVDYRLLEASKAGDLETVKQLCSPQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLVKEGDTDIQDLLRGDAALLDAAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLERGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLATADDIRALLIDAMPPEALPTCFKPQATVVSASLISPASTPSCLSAASSIDNLTGPLAELAVGGASNAGDGAAGAERKEGEVAGLDMNISQFLKSLGLEHLRDIFETEQITLDVLADMGHEELKEIGINAYGHRHKLIKGVERLLGGQQGTNPYLTFHCVNQGTILLDLAPEDKEYQSVEEEMQSTIREHRDGGNAGGIFNRYNVIRIQKVVNKKLRERFCHRQKEVSEENHNHHNERMLFHGSPFINAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPTHKDRSCYVCHRQMLFCRVTLGKSFLQFSTMKMAHAPPGHHSVIGRPSVNGLAYAEYVIYRGEQAYPEYLITYQIMKPEAPSQTATAAEQKT", "length": 1313, "header": "tr|A0A8I5YBL7-1|A0A8I5YBL7_RAT Computationally mapped isoform of Poly [ADP-ribose] polymerase OS=Rattus norvegicus OX=10116 GN=Tnks PE=1 SV=1 CANONICAL=D3Z8Q6-1" }, "locus": { "chromosome": "16", "start_pos": 57365661, "end_pos": 57225119, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000108961.1", "url": "https://www.ensembl.org/id/ENSRNOT00000108961.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000076451.1", "url": "https://www.ensembl.org/id/ENSRNOP00000076451.1" } ] } }, { "isoform_ac": "D3Z8Q6-1", "url": "", "sequence": { "sequence": "MAASRRSQHHHHHHQQQLQPAPGASAPPPPPPPPLSPGLAPGPTPASPTAGGLAPFASPRHGLALPEGDGSRDPPDRPRSPDPVDGAVCTVAATAAAPAASAAVGVAPSPAGGGGNNSASSTSSPTSSSSSSPSSPGSSIAESPEAAGVGSTATLGPGAAGLGPGVPAVSGALRELLEACRNGDVSRVKRLVDAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVASLHPKRKQVAELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDSLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFTAAQMGNEAVQQILSESTPIRTSDVDYRLLEASKAGDLETVKQLCSPQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLVKEGDTDIQDLLRGDAALLDAAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLERGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLATADDIRALLIDAMPPEALPTCFKPQATVVSASLISPASTPSCLSAASSIDNLTGPLAELAVGGASNAGDGAAGAERKEGEVAGLDMNISQFLKSLGLEHLRDIFETEQITLDVLADMGHEELKEIGINAYGHRHKLIKGVERLLGGQQGTNPYLTFHCVNQGTILLDLAPEDKEYQSVEEEMQSTIREHRDGGNAGGIFNRYNVIRIQKVVNKKLRERFCHRQKEVSEENHNHHNERMLFHGSPFINAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPTHKDRSCYVCHRQMLFCRVTLGKSFLQFSTMKMAHAPPGHHSVIGRPSVNGLAYAEYVIYRGEQAYPEYLITYQIMKPEAPSQTATAAEQKT", "length": 1317, "header": "tr|D3Z8Q6-1|D3Z8Q6_RAT Isoform 1 of Poly [ADP-ribose] polymerase OS=Rattus norvegicus OX=10116 GN=Tnks PE=1 SV=1 CANONICAL=D3Z8Q6-1" }, "locus": { "chromosome": "16", "start_pos": 57365661, "end_pos": 57225119, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000015813.7", "url": "https://www.ensembl.org/id/ENSRNOT00000015813.7" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000015813.5", "url": "https://www.ensembl.org/id/ENSRNOP00000015813.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Nutritional energy stimulates NAD+ production to promote tankyrase-mediated PARsylation in insulinoma cells.", "journal": "PloS one", "date": "2015", "authors": "Zhong L, Yeh TY, Hao J, Pourtabatabaei N, Mahata SK, Shao J, Chessler SD, Chi NW", "evidence": [ { "database": "RefSeq", "id": "NP_001099554", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099554" } ], "reference": [ { "type": "PubMed", "id": "25876076", "url": "https://glygen.org/publication/PubMed/25876076" } ] }, { "title": "Tankyrase inhibition regulates corpus luteum development and luteal function in gonadotropin-treated rats.", "journal": "Molecular reproduction and development", "date": "2017", "authors": "Accialini P, Irusta G, Bechis A, Bas D, Parborell F, Abramovich D, Tesone M", "evidence": [ { "database": "RefSeq", "id": "NP_001099554", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099554" } ], "reference": [ { "type": "PubMed", "id": "28628258", "url": "https://glygen.org/publication/PubMed/28628258" } ] } ], "pathway": [ { "id": "rno:290794", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:290794", "resource": "KEGG Pathway" }, { "id": "R-RNO-201681", "name": "TCF dependent signaling in response to WNT", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-201681", "resource": "Reactome", "description": "TCF dependent signaling in response to WNT" }, { "id": "R-RNO-4641257", "name": "Degradation of AXIN", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-4641257", "resource": "Reactome", "description": "Degradation of AXIN" }, { "id": "R-RNO-5689880", "name": "Ub-specific processing proteases", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5689880", "resource": "Reactome", "description": "Ub-specific processing proteases" }, { "id": "R-RNO-8948751", "name": "Regulation of PTEN stability and activity", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8948751", "resource": "Reactome", "description": "Regulation of PTEN stability and activity" } ], "orthologs": [ { "uniprot_canonical_ac": "O95271-1", "protein_name": "Poly [ADP-ribose] polymerase tankyrase-1", "gene_name": "TNKS", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAASRRSQHHHHHHQQQLQPAPGASAPPPPPPPPLSPGLAPGTTPASPTASGLAPFASPRHGLALPEGDGSRDPPDRPRSPDPVDGTSCCSTTSTICTVAAAPVVPAVSTSSAAGVAPNPAGSGSNNSPSSSSSPTSSSSSSPSSPGSSLAESPEAAGVSSTAPLGPGAAGPGTGVPAVSGALRELLEACRNGDVSRVKRLVDAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFTAAQMGNEAVQQILSESTPIRTSDVDYRLLEASKAGDLETVKQLCSSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLVKEGDTDIQDLLRGDAALLDAAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLATADDIRALLIDAMPPEALPTCFKPQATVVSASLISPASTPSCLSAASSIDNLTGPLAELAVGGASNAGDGAAGTERKEGEVAGLDMNISQFLKSLGLEHLRDIFETEQITLDVLADMGHEELKEIGINAYGHRHKLIKGVERLLGGQQGTNPYLTFHCVNQGTILLDLAPEDKEYQSVEEEMQSTIREHRDGGNAGGIFNRYNVIRIQKVVNKKLRERFCHRQKEVSEENHNHHNERMLFHGSPFINAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPTHKDRSCYICHRQMLFCRVTLGKSFLQFSTMKMAHAPPGHHSVIGRPSVNGLAYAEYVIYRGEQAYPEYLITYQIMKPEAPSQTATAAEQKT", "length": 1327 }, "evidence": [ { "id": "45236883", "url": "http://www.informatics.jax.org/homology/45236883", "database": "MGI" } ], "common_name": "Human" }, { "uniprot_canonical_ac": "Q6PFX9-1", "protein_name": "Poly [ADP-ribose] polymerase tankyrase-1", "gene_name": "Tnks", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAASRRSQHHHHHHQQQLQPAPGASAPPPPPPPPLSPGLAPGPTPASPTAGGLAPFASPRHGLALPEGDGSRDPPDRPRSPDPVDGAVCTVAAPAAVPAASAAVGVAPTPAGGGGGGGNNSASSASSPTSSSSSSPSSPGSSLAESPEAAGVGSTATLGAGAAGLGPGVPAVSGALRELLEACRNGDVSRVKRLVDAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVASLHPKRKQVAELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDSLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFTAAQMGNEAVQQILSESTPMRTSDVDYRLLEASKAGDLETVKQLCSPQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLVKEGDTDIQDLLRGDAALLDAAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLATADDIRALLIDAMPPEALPTCFKPQATVVSASLISPASTPSCLSAASSIDNLTGPLTDLAVGGASNAGDGAAGAERKEGEVAGLDMNISQFLKSLGLEHLRDIFETEQITLDVLADMGHEELKEIGINAYGHRHKLIKGVERLLGGQQGTNPYLTFHCVNQGTILLDLAPEDKEYQSVEEEMQSTIREHRDGGNAGGIFNRYNVIRIQKVVNKKLRERFCHRQKEVSEENHNHHNERMLFHGSPFINAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPTHKDRSCYICHRQMLFCRVTLGKSFLQFSTMKMAHAPPGHHSVIGRPSVNGLAYAEYVIYRGEQAYPEYLITYQIMKPEAPSQTATAAEQKT", "length": 1320 }, "evidence": [ { "id": "45236883", "url": "http://www.informatics.jax.org/homology/45236883", "database": "MGI" } ], "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "NAD+-protein ADP-ribosyltransferase activity", "id": "GO:1990404", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990404", "evidence": [ { "database": "UniProtKB", "id": "D3Z8Q6", "url": "https://www.uniprot.org/uniprot/D3Z8Q6" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "D3Z8Q6", "url": "https://www.uniprot.org/uniprot/D3Z8Q6" } ], "pmid": "" }, { "name": "histone binding", "id": "GO:0042393", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042393", "evidence": [ { "database": "UniProtKB", "id": "D3Z8Q6", "url": "https://www.uniprot.org/uniprot/D3Z8Q6" } ], "pmid": "" }, { "name": "NAD+ ADP-ribosyltransferase activity", "id": "GO:0003950", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003950", "evidence": [ { "database": "UniProtKB", "id": "D3Z8Q6", "url": "https://www.uniprot.org/uniprot/D3Z8Q6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 15, "go_terms": [ { "name": "cellular response to nutrient", "id": "GO:0031670", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031670", "evidence": [ { "database": "UniProtKB", "id": "D3Z8Q6", "url": "https://www.uniprot.org/uniprot/D3Z8Q6" } ], "pmid": "" }, { "name": "protein auto-ADP-ribosylation", "id": "GO:0070213", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070213", "evidence": [ { "database": "UniProtKB", "id": "D3Z8Q6", "url": "https://www.uniprot.org/uniprot/D3Z8Q6" } ], "pmid": "" }, { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "D3Z8Q6", "url": "https://www.uniprot.org/uniprot/D3Z8Q6" } ], "pmid": "" }, { "name": "positive regulation of telomere maintenance via telomerase", "id": "GO:0032212", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032212", "evidence": [ { "database": "UniProtKB", "id": "D3Z8Q6", "url": "https://www.uniprot.org/uniprot/D3Z8Q6" } ], "pmid": "" }, { "name": "positive regulation of telomerase activity", "id": "GO:0051973", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051973", "evidence": [ { "database": "UniProtKB", "id": "D3Z8Q6", "url": "https://www.uniprot.org/uniprot/D3Z8Q6" } ], "pmid": "" }, { "name": "protein localization to chromosome, telomeric region", "id": "GO:0070198", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070198", "evidence": [ { "database": "UniProtKB", "id": "D3Z8Q6", "url": "https://www.uniprot.org/uniprot/D3Z8Q6" } ], "pmid": "" }, { "name": "peptidyl-threonine phosphorylation", "id": "GO:0018107", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0018107", "evidence": [ { "database": "UniProtKB", "id": "D3Z8Q6", "url": "https://www.uniprot.org/uniprot/D3Z8Q6" } ], "pmid": "" }, { "name": "positive regulation of canonical Wnt signaling pathway", "id": "GO:0090263", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090263", "evidence": [ { "database": "UniProtKB", "id": "D3Z8Q6", "url": "https://www.uniprot.org/uniprot/D3Z8Q6" } ], "pmid": "" }, { "name": "protein polyubiquitination", "id": "GO:0000209", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000209", "evidence": [ { "database": "UniProtKB", "id": "D3Z8Q6", "url": "https://www.uniprot.org/uniprot/D3Z8Q6" } ], "pmid": "" }, { "name": "peptidyl-serine phosphorylation", "id": "GO:0018105", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0018105", "evidence": [ { "database": "UniProtKB", "id": "D3Z8Q6", "url": "https://www.uniprot.org/uniprot/D3Z8Q6" } ], "pmid": "" }, { "name": "positive regulation of telomere capping", "id": "GO:1904355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904355", "evidence": [ { "database": "UniProtKB", "id": "D3Z8Q6", "url": "https://www.uniprot.org/uniprot/D3Z8Q6" } ], "pmid": "" }, { "name": "negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric", "id": "GO:1904908", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904908", "evidence": [ { "database": "UniProtKB", "id": "D3Z8Q6", "url": "https://www.uniprot.org/uniprot/D3Z8Q6" } ], "pmid": "" }, { "name": "protein poly-ADP-ribosylation", "id": "GO:0070212", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070212", "evidence": [ { "database": "UniProtKB", "id": "D3Z8Q6", "url": "https://www.uniprot.org/uniprot/D3Z8Q6" } ], "pmid": "" }, { "name": "negative regulation of telomeric DNA binding", "id": "GO:1904743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904743", "evidence": [ { "database": "UniProtKB", "id": "D3Z8Q6", "url": "https://www.uniprot.org/uniprot/D3Z8Q6" } ], "pmid": "" }, { "name": "negative regulation of telomere maintenance via telomere lengthening", "id": "GO:1904357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904357", "evidence": [ { "database": "UniProtKB", "id": "D3Z8Q6", "url": "https://www.uniprot.org/uniprot/D3Z8Q6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 6, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "D3Z8Q6", "url": "https://www.uniprot.org/uniprot/D3Z8Q6" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "D3Z8Q6", "url": "https://www.uniprot.org/uniprot/D3Z8Q6" } ], "pmid": "" }, { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "D3Z8Q6", "url": "https://www.uniprot.org/uniprot/D3Z8Q6" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "D3Z8Q6", "url": "https://www.uniprot.org/uniprot/D3Z8Q6" } ], "pmid": "" }, { "name": "mitotic spindle pole", "id": "GO:0097431", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097431", "evidence": [ { "database": "UniProtKB", "id": "D3Z8Q6", "url": "https://www.uniprot.org/uniprot/D3Z8Q6" } ], "pmid": "" }, { "name": "chromosome, telomeric region", "id": "GO:0000781", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000781", "evidence": [ { "database": "UniProtKB", "id": "D3Z8Q6", "url": "https://www.uniprot.org/uniprot/D3Z8Q6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1020, "end_pos": 1022, "annotation": "n_glycosylation_sequon" }, { "start_pos": 116, "end_pos": 118, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1207, "end_pos": 1209, "annotation": "n_glycosylation_sequon" }, { "start_pos": 272, "end_pos": 274, "annotation": "n_glycosylation_sequon" }, { "start_pos": 827, "end_pos": 829, "annotation": "n_glycosylation_sequon" }, { "start_pos": 887, "end_pos": 889, "annotation": "n_glycosylation_sequon" }, { "start_pos": 984, "end_pos": 986, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "R-RNO-3640844", "name": "RNF146 binds RibC-AXIN:TNKS complex", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q5XIK5-1", "D3Z8Q6-1" ], "evidence": [ { "id": "R-RNO-3640844", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-3640844" } ] }, { "id": "R-RNO-3640858", "name": "Tankyrase ADP-ribosylates AXIN", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [ "R-ALL-197277" ], "enzyme_list": [ "D3Z8Q6-1" ], "evidence": [ { "id": "R-RNO-3640858", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-3640858" } ] }, { "id": "R-RNO-3640861", "name": "RNF146 ubiquitinates ADP-ribosylated AXIN", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q5XIK5-1", "D3Z8Q6-1" ], "evidence": [ { "id": "R-RNO-3640861", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-3640861" } ] }, { "id": "R-RNO-3640862", "name": "Tankyrase binds AXIN", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "D3Z8Q6-1" ], "evidence": [ { "id": "R-RNO-3640862", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-3640862" } ] }, { "id": "R-RNO-3640872", "name": "USP34 deubiquitinates AXIN1,AXIN2", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q5XIK5-1", "D3Z8Q6-1", "A0A8I5ZVK3-1" ], "evidence": [ { "id": "R-RNO-3640872", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-3640872" } ] }, { "id": "R-RNO-3640874", "name": "Ub-RibC-AXIN is degraded by the proteasome", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q5XIK5-1", "D3Z8Q6-1", "P28064-1", "P28073-1", "P28075-1", "P28077-1", "Q4KM35-1", "Q9JHW0-1" ], "evidence": [ { "id": "R-RNO-3640874", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-3640874" } ] }, { "id": "R-RNO-8948800", "name": "TNKS and TNKS2 PARylate PTEN", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [ "R-RNO-8948798" ], "enzyme_list": [ "D3Z8Q6-1", "O54857-1" ], "evidence": [ { "id": "R-RNO-8948800", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8948800" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-197277", "participant_name": "NAM [cytosol]", "crossref": [ { "id": "C00153", "database": "COMPOUND", "url": "" }, { "id": "17154", "database": "ChEBI", "url": "" }, { "id": "HMDB0001406", "database": "HMDB Metabolite", "url": "" }, { "id": "000000005878", "database": "ZINC", "url": "" }, { "id": "C00153", "database": "COMPOUND", "url": "" }, { "id": "17154", "database": "ChEBI", "url": "" }, { "id": "HMDB0001406", "database": "HMDB Metabolite", "url": "" }, { "id": "000000005878", "database": "ZINC", "url": "" }, { "id": "C00153", "database": "COMPOUND", "url": "" }, { "id": "17154", "database": "ChEBI", "url": "" }, { "id": "HMDB0001406", "database": "HMDB Metabolite", "url": "" }, { "id": "000000005878", "database": "ZINC", "url": "" }, { "id": "HMDB0001406", "database": "HMDB Metabolite", "url": "" }, { "id": "C00153", "database": "COMPOUND", "url": "" }, { "id": "000000005878", "database": "ZINC", "url": "" }, { "id": "17154", "database": "ChEBI", "url": "" }, { "id": "C00153", "database": "COMPOUND", "url": "" }, { "id": "17154", "database": "ChEBI", "url": "" }, { "id": "HMDB0001406", "database": "HMDB Metabolite", "url": "" }, { "id": "000000005878", "database": "ZINC", "url": "" } ] }, { "participant_id": "R-RNO-8948798", "participant_name": "phospho-Pten [cytosol]", "crossref": [ { "id": "O54857", "database": "UniProt", "url": "" }, { "id": "NP_113794.1", "database": "RefSeq", "url": "" }, { "id": "ENSRNOG00000020723", "database": "Ensembl", "url": "" }, { "id": "ENSRNOT00000028143", "database": "Ensembl", "url": "" }, { "id": "3.1.3.16", "database": "IntEnz", "url": "" }, { "id": "ENSRNOP00000028143", "database": "Ensembl", "url": "" }, { "id": "2K20", "database": "PDB", "url": "" }, { "id": "61995", "database": "RGD", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0A8I5ZVK3", "gene_name": "Usp34", "activity": [ { "ec_number": "3.4.19.12", "activity": "Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).", "evidence": [ { "id": "A0A8I5ZVK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZVK3" } ] }, { "ec_number": "3.4.19.12", "activity": "", "evidence": [ { "id": "A0A8I5ZVK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZVK3" } ] } ] }, { "uniprot_ac": "D3Z8Q6", "gene_name": "Tnks", "activity": [ { "ec_number": "2.4.2.-", "activity": "", "evidence": [ { "id": "D3Z8Q6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3Z8Q6" } ] } ] }, { "uniprot_ac": "O54857", "gene_name": "Pten", "activity": [ { "ec_number": "3.1.3.67", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate.", "evidence": [ { "id": "O54857", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54857" } ] }, { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "O54857", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54857" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "O54857", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54857" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "O54857", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54857" } ] }, { "ec_number": "3.1.3.67", "activity": "", "evidence": [ { "id": "O54857", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54857" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "O54857", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54857" } ] } ] }, { "uniprot_ac": "P28064", "gene_name": "Psmb8", "activity": [ { "ec_number": "3.4.25.1", "activity": "Cleavage of peptide bonds with very broad specificity.", "evidence": [ { "id": "P28064", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28064" } ] }, { "ec_number": "3.4.25.1", "activity": "", "evidence": [ { "id": "P28064", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28064" } ] } ] }, { "uniprot_ac": "P28073", "gene_name": "Psmb6", "activity": [ { "ec_number": "3.4.25.1", "activity": "Cleavage of peptide bonds with very broad specificity.", "evidence": [ { "id": "P28073", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28073" } ] }, { "ec_number": "3.4.25.1", "activity": "", "evidence": [ { "id": "P28073", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28073" } ] } ] }, { "uniprot_ac": "P28075", "gene_name": "Psmb5", "activity": [ { "ec_number": "3.4.25.1", "activity": "Cleavage of peptide bonds with very broad specificity.", "evidence": [ { "id": "P28075", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28075" } ] }, { "ec_number": "3.4.25.1", "activity": "", "evidence": [ { "id": "P28075", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28075" } ] } ] }, { "uniprot_ac": "P28077", "gene_name": "Psmb9", "activity": [ { "ec_number": "3.4.25.1", "activity": "Cleavage of peptide bonds with very broad specificity.", "evidence": [ { "id": "P28077", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28077" } ] }, { "ec_number": "3.4.25.1", "activity": "", "evidence": [ { "id": 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