{ "uniprot_canonical_ac": "D3YWQ0-1", "uniprot_ac": "D3YWQ0", "uniprot_id": "DGKI_MOUSE", "mass": { "chemical_mass": 118209.0, "monoisotopic_mass": 118209.0 }, "refseq": { "ac": "NP_001334033", "name": "diacylglycerol kinase iota isoform 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334033" }, "gene_names": [ { "name": "Dgki", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/D3YWQ0", "id": "D3YWQ0" }, { "name": "6430604M11Rik; C130010K08Rik", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334033", "id": "NP_001334033" }, { "name": "Dgki", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334033", "id": "NP_001334033" } ], "protein_names": [ { "name": "Diacylglycerol kinase iota", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "D3YWQ0" }, { "name": "2.7.1.107", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "D3YWQ0" }, { "name": "DAG kinase iota", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334033", "id": "NP_001334033" }, { "name": "DAG kinase iota", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "D3YWQ0" }, { "name": "diacylglycerol kinase iota isoform 2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334033", "id": "NP_001334033" } ], "function": [ { "annotation": "Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids. Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes. Has probably no preference for any of the diacylglycerols in terms of the acyl chain composition, especially for the acyl chain at the sn-2 position (By similarity). By controlling the diacylglycerol/DAG-mediated activation of RASGRP3, negatively regulates the Rap1 signaling pathway (PubMed:15894621). May play a role in presynaptic diacylglycerol/DAG signaling and control neurotransmitter release during metabotropic glutamate receptor-dependent long-term depression (PubMed:21119615).", "evidence": [ { "database": "UniProtKB", "id": "D3YWQ0", "url": "https://www.uniprot.org/uniprot/D3YWQ0#function" }, { "database": "PubMed", "id": "15894621", "url": "https://glygen.org/publication/PubMed/15894621" }, { "database": "UniProtKB", "id": "O75912", "url": "https://www.uniprot.org/uniprot/O75912#function" }, { "database": "PubMed", "id": "21119615", "url": "https://glygen.org/publication/PubMed/21119615" } ] }, { "annotation": "Mania- and anxiety-like behavior and impaired maternal care in female diacylglycerol kinase eta and iota double knockout mice.", "evidence": [ { "database": "RefSeq", "id": "NP_001334033", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334033" }, { "database": "PubMed", "id": "30985063", "url": "https://glygen.org/publication/PubMed/30985063" } ] }, { "annotation": "These data suggest Dgki regulates sensory neuron and behavioral responses to histamine. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001334033", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334033" }, { "database": "PubMed", "id": "31167004", "url": "https://glygen.org/publication/PubMed/31167004" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "D3YWQ0", "url": "https://www.uniprot.org/uniprot/D3YWQ0" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Dgki", "url": "https://www.uniprot.org/uniprot/D3YWQ0", "locus": { "chromosome": "6", "start_pos": 36822957, "end_pos": 37277119, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000038665", "url": "https://www.ensembl.org/id/ENSMUSG00000038665" } ] } } ], "crossref": [ { "id": "ENSMUSG00000038665", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000038665", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd20850", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd20850", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd20896", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd20896", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "320127", "url": "https://www.ncbi.nlm.nih.gov/gene/320127", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "D3YWQ0", "url": "https://www.ebi.ac.uk/intact/interactors/id:D3YWQ0*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR000756", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000756", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001206", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001206", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002219", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002219", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016064", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016064", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017438", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017438", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036770", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036770", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037607", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037607", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047486", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047486", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047487", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047487", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "mmu:320127", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:320127", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "2443430", "url": "http://www.informatics.jax.org/marker/MGI:2443430", "database": "MGI", "categories": [ "Organism-specific" ] }, { "id": "AXIPLGI", "url": "https://omabrowser.org/oma/group/AXIPLGI/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "4642163at2759", "url": "http://www.orthodb.org/?query=4642163at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11255", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11255", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11255:SF92", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11255:SF92", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00130", "url": "http://pfam.xfam.org/family/PF00130", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF00609", "url": "http://pfam.xfam.org/family/PF00609", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF00781", "url": "http://pfam.xfam.org/family/PF00781", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF12796", "url": "http://pfam.xfam.org/family/PF12796", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_D3YWQ0", "url": "http://purl.obolibrary.org/obo/PR_D3YWQ0", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-MMU-114508", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-114508", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_001334033", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334033", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "10272", "url": "https://www.rhea-db.org/rhea/10272", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "40323", "url": "https://www.rhea-db.org/rhea/40323", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "40327", "url": "https://www.rhea-db.org/rhea/40327", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "40339", "url": "https://www.rhea-db.org/rhea/40339", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "D3YWQ0", "url": "https://www.uniprot.org/uniprot/D3YWQ0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "D3YWQ0-1", "url": "https://www.uniprot.org/uniprot/D3YWQ0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "D3YWQ0-2", "url": "https://www.uniprot.org/uniprot/D3YWQ0-2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "D3Z519", "url": "https://www.uniprot.org/uniprot/D3Z519", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "D3Z519-1", "url": "https://www.uniprot.org/uniprot/D3Z519-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "S4R215", "url": "https://www.uniprot.org/uniprot/S4R215", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "S4R215-1", "url": "https://www.uniprot.org/uniprot/S4R215-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "S4R2G0", "url": "https://www.uniprot.org/uniprot/S4R2G0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "S4R2G0-1", "url": "https://www.uniprot.org/uniprot/S4R2G0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDAAGRGCHLLPLPAARGPARAPAASSALSPTGLCSGTTSASFAAAGAVAMNPSSSAGEERGATGGSSSSGSGAGSCCLGAEGGADPRGAGAAAAAALEEPAAAGQKEKEEALEEKLRDLTFRKQVSYRKAISRTGLQHLAPAHPLGLPVANGPAKEPRATLDWSENAVNGEHLWLETNVSGDLCYLGEENCQVRFAKSALRRKCAVCKIVVHTACIEQLEKINFRCKPTFREGGSRSPRENFVRHHWVHRRRQEGKCKQCGKGFQQKFSFHSKEIVAISCSWCKQAFHNKVTCFMLHHIEEPCSLGAHAAVIVPPTWIIKVKKPQNSLKASNRKKKRTSFKRKASKRGTEQETKGRPFVIKPISSPLMKPLLVFVNPKSGGNQGTKVLQMFMWYLNPRQVFDLSQEGPKDALEMYRKVPNLRILACGGDGTVGWILSILDELQLSPQPPVGVLPLGTGNDLARTLNWGGGYTDEPVSKILCQVEDGTIVQLDRWNLHVERNPDLPPEELEDGVCKLPLNVFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGAAFSDFLQRSSRDLSKHVKVVCDGTDLTPKIQDLKFQCIVFLNIPRYCAGTMPWGNPGDHHDFEPQRHDDGYIEVIGFTMASLAALQVGGHGERLHQCREVMLLTYKSIPMQVDGEPCRLAPAMIRISLRNQANMVQKSKRRTSMPLLNDIHQVQAADLRRVSAPPGSFTIPQSVPDRLRIRVNKISLQDYEGLHYDKDKLREASIPLGILVVRGDCDLETCRMYIDRLQEDLQSVSSGSQRVHYQDQETSFPRALSAQRLSPRWCFLDATSADRFYRIDRSQEHLHFVMEISHDEIFILDPDMVVSQQAGTPPGMPDLVVEQASGLSDWWNPALRKRMLSDSGMITPHYEDSDLKDFSHSRVLQSPVSSEDHAILQAVLTGDLMKLMESYKNGGSLLIQGPGHCSLLHYAAKTGNGDIVKYILDHGPAELLDMADSETGETALHKAACQRNRAVCQLLVDAGASLRQTDSKGKTPQERAQQAGDPDLAAYLESRQNYKIIGHEDLETAV", "length": 1071, "header": "sp|D3YWQ0-1|DGKI_MOUSE Isoform 1 of Diacylglycerol kinase iota OS=Mus musculus OX=10090 GN=Dgki PE=1 SV=1 CANONICAL=D3YWQ0-1" }, "isoforms": [ { "isoform_ac": "D3YWQ0-1", "url": "", "sequence": { "sequence": "MDAAGRGCHLLPLPAARGPARAPAASSALSPTGLCSGTTSASFAAAGAVAMNPSSSAGEERGATGGSSSSGSGAGSCCLGAEGGADPRGAGAAAAAALEEPAAAGQKEKEEALEEKLRDLTFRKQVSYRKAISRTGLQHLAPAHPLGLPVANGPAKEPRATLDWSENAVNGEHLWLETNVSGDLCYLGEENCQVRFAKSALRRKCAVCKIVVHTACIEQLEKINFRCKPTFREGGSRSPRENFVRHHWVHRRRQEGKCKQCGKGFQQKFSFHSKEIVAISCSWCKQAFHNKVTCFMLHHIEEPCSLGAHAAVIVPPTWIIKVKKPQNSLKASNRKKKRTSFKRKASKRGTEQETKGRPFVIKPISSPLMKPLLVFVNPKSGGNQGTKVLQMFMWYLNPRQVFDLSQEGPKDALEMYRKVPNLRILACGGDGTVGWILSILDELQLSPQPPVGVLPLGTGNDLARTLNWGGGYTDEPVSKILCQVEDGTIVQLDRWNLHVERNPDLPPEELEDGVCKLPLNVFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGAAFSDFLQRSSRDLSKHVKVVCDGTDLTPKIQDLKFQCIVFLNIPRYCAGTMPWGNPGDHHDFEPQRHDDGYIEVIGFTMASLAALQVGGHGERLHQCREVMLLTYKSIPMQVDGEPCRLAPAMIRISLRNQANMVQKSKRRTSMPLLNDIHQVQAADLRRVSAPPGSFTIPQSVPDRLRIRVNKISLQDYEGLHYDKDKLREASIPLGILVVRGDCDLETCRMYIDRLQEDLQSVSSGSQRVHYQDQETSFPRALSAQRLSPRWCFLDATSADRFYRIDRSQEHLHFVMEISHDEIFILDPDMVVSQQAGTPPGMPDLVVEQASGLSDWWNPALRKRMLSDSGMITPHYEDSDLKDFSHSRVLQSPVSSEDHAILQAVLTGDLMKLMESYKNGGSLLIQGPGHCSLLHYAAKTGNGDIVKYILDHGPAELLDMADSETGETALHKAACQRNRAVCQLLVDAGASLRQTDSKGKTPQERAQQAGDPDLAAYLESRQNYKIIGHEDLETAV", "length": 1071, "header": "sp|D3YWQ0-1|DGKI_MOUSE Isoform 1 of Diacylglycerol kinase iota OS=Mus musculus OX=10090 GN=Dgki PE=1 SV=1 CANONICAL=D3YWQ0-1" }, "locus": { "chromosome": "6", "start_pos": 37276883, "end_pos": 36824314, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000101532", "url": "https://www.ensembl.org/id/ENSMUST00000101532" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000099071", "url": "https://www.ensembl.org/id/ENSMUSP00000099071" } ] } }, { "isoform_ac": "D3YWQ0-2", "url": "", "sequence": { "sequence": "MDAAGRGCHLLPLPAARGPARAPAASSALSPTGLCSGTTSASFAAAGAVAMNPSSSAGEERGATGGSSSSGSGAGSCCLGAEGGADPRGAGAAAAAALEEPAAAGQKEKEEALEEKLRDLTFRKQVSYRKAISRTGLQHLAPAHPLGLPVANGPAKEPRATLDWSENAVNGEHLWLETNVSGDLCYLGEENCQVRFAKSALRRKCAVCKIVVHTACIEQLEKINFRCKPTFREGGSRSPRENFVRHHWVHRRRQEGKCKQCGKGFQQKFSFHSKEIVAISCSWCKQAFHNKVTCFMLHHIEEPCSLGAHAAVIVPPTWIIKVKKPQNSLKASNRKKKRTSFKRKASKRGTEQETKGRPFVIKPISSPLMKPLLVFVNPKSGGNQGTKVLQMFMWYLNPRQVFDLSQEGPKDALEMYRKVPNLRILACGGDGTVGWILSILDELQLSPQPPVGVLPLGTGNDLARTLNWGGGYTDEPVSKILCQVEDGTIVQLDRWNLHVERNPDLPPEELEDGVCKLPLNVFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGAAFSDFLQRSSRDLSKHVKVVCDGTDLTPKIQDLKFQCIVFLNIPRYCAGTMPWGNPGDHHDFEPQRHDDGYIEVIGFTMASLAALQVGGHGERLHQCREVMLLTYKSIPMQVDGEPCRLAPAMIRISLRNQANMVQKSKRRTSMPLLNDPQSVPDRLRIRVNKISLQDYEGLHYDKDKLREASIPLGILVVRGDCDLETCRMYIDRLQEDLQSVSSGSQRVHYQDQETSFPRALSAQRLSPRWCFLDATSADRFYRIDRSQEHLHFVMEISHDEIFILDPDMVVSQQAGTPPGMPDLVVEQASGLSDWWNPALRKRMLSDSGMITPHYEDSDLKDFSHSRVLQSPVSSEDHAILQAVLTGDLMKLMESYKNGGSLLIQGPGHCSLLHYAAKTGNGDIVKYILDHGPAELLDMADSETGETALHKAACQRNRAVCQLLVDAGASLRQTDSKGKTPQERAQQAGDPDLAAYLESRQNYKIIGHEDLETAV", "length": 1050, "header": "sp|D3YWQ0-2|DGKI_MOUSE Isoform 2 of Diacylglycerol kinase iota OS=Mus musculus OX=10090 GN=Dgki PE=1 SV=1 CANONICAL=D3YWQ0-1" }, "locus": { "chromosome": "6", "start_pos": 37276883, "end_pos": 36824314, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000090314", "url": "https://www.ensembl.org/id/ENSMUST00000090314" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000087788", "url": "https://www.ensembl.org/id/ENSMUSP00000087788" } ] } }, { "isoform_ac": "D3Z519-1", "url": "", "sequence": { "sequence": "MVKLKVLAGNATNLENAVNGEHLWLETNVSGDLCYLGEENCQVRFAKSALRRKCAVCKIVVHTACIEQLEKINFRCKPTFREGGSRSPRENFVRHHWVHRRRQEGKCKQCGKGFQQKFSFHSKEIVAISCSWCKQAFHNKVTCFMLHHIEEPCSLGAHAAVIVPPTWIIKVKKPQNSLKASNRKKKRTSFKRKASKRGTEQETKGRPFVIKPISSPLMKPLLVFVNPKSGGNQGTKVLQMFMWYLNPRQVFDLSQEGPKDALEMYRKVPNLRILACGGDGTVGWILSILDELQLSPQPPVGVLPLGTGNDLARTLNWGGGYTDEPVSKILCQVEDGTIVQLDRWNLHVERNPDLPPEELEDGVCKLPLNVFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGAAFSDFLQRSSRDLSKHVKVVCDGTDLTPKIQDLKFQCIVFLNIPRYCAGTMPWGNPGDHHDFEPQRHDDGYIEVIGFTMASLAALQVGGHGERLHQCREVMLLTYKSIPMQVDGEPCRLAPAMIRISLRNQANMVQKSKRRTSMPLLNDPQSVPDRLRIRVNKISLQDYEGLHYDKDKLREASIPLGILVVRGDCDLETCRMYIDRLQEDLQSVSSGSQRVHYQDQETSFPRALSAQRLSPRWCFLDATSADRFYRIDRSQEHLHFVMEISHDEIFILDPDMVVSQQAGTPPGMPDLVVEQASGLSDWWNPALRKRMLSDSGMITPHYEDSDLKDFSHSRVLQSPVSSEDHAILQAVLTGDLMKLMESYKNGGSLLIQGPGHCSLLHYAAKTGNGDIVKYILDHGPAELLDMADSETGETALHKAACQRNRAVCQLLVDAGASLRQTDSKGKTPQERAQQAGDPDLAAYLESRQNYKIIGHEDLETAV", "length": 899, "header": "tr|D3Z519-1|DGKI_MOUSE Computationally mapped isoform of Diacylglycerol kinase iota OS=Mus musculus OX=10090 GN=Dgki PE=1 SV=1 CANONICAL=D3YWQ0-1" }, "locus": { "chromosome": "6", "start_pos": 37273649, "end_pos": 36824314, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000042075.8", "url": "https://www.ensembl.org/id/ENSMUST00000042075.8" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000047858.8", "url": "https://www.ensembl.org/id/ENSMUSP00000047858.8" } ] } }, { "isoform_ac": "S4R215-1", "url": "", "sequence": { "sequence": "MDAAGRGCHLLPLPAARGPARAPAASSALSPTGLCSGTTSASFAAAGAVAMNPSSSAGEERGATGGSSSSGSGAGSCCLGAEGGADPRGAGAAAAAALEEPAAAGQKEKEEALEEKLRDLTFRKQVSYRKAISRTGLQHLAPAHPLGLPVANGPAKEPRATLDWSENAVNGEHLWLETNVSGDLCYLGEENCQVRFAKSALRRKCAVCKIVVHTACIEQLEKINFRCKPTFREGGSRSPRENFVRHHWVHRRRQEGKCKQCGKGFQQKFSFHSKEIVAISCSWCKQAFHNKVTCFMLHHIEEPCSLGAHAAVIVPPTWIIKVKKPQNSLKASNRKKKRTSFKRKASKRGTEQETKGRPFVIKPISSPLMKPLLVFVNPKSGGNQGTKVLQMFMWYLNPRQVFDLSQEGPKDALEMYRKVPNLRILACGGDGTVGWILSILDELQLSPQPPVGVLPLGTGNDLARTLNWGGGYTDEPVSKILCQVEDGTIVQLDRWNLHVERNPDLPPEELEDGVCKLPLNVFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGAAFSDFLQRSSRDLSKHVKVVLSWMRLSDS", "length": 591, "header": "tr|S4R215-1|DGKI_MOUSE Computationally mapped isoform of Diacylglycerol kinase iota OS=Mus musculus OX=10090 GN=Dgki PE=1 SV=1 CANONICAL=D3YWQ0-1" }, "locus": { "chromosome": "6", "start_pos": 37276883, "end_pos": 36993658, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000150300.9", "url": "https://www.ensembl.org/id/ENSMUST00000150300.9" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000138457.2", "url": "https://www.ensembl.org/id/ENSMUSP00000138457.2" } ] } }, { "isoform_ac": "S4R2G0-1", "url": "", "sequence": { "sequence": "MDAAGRGCHLLPLPAARGPARAPAASSALSPTGLCSGTTSASFAAAGAVAMNPSSSAGEERGATGGSSSSGSGAGSCCLGAEGGADPRGAGAAAAAALEEPAAAGQKEKEEALEEKLRDLTFRKQVSYRKAISRTGLQHLAPAHPLGLPVANGPAKEPRATLDWSENAVNGEHLWLETNVSGDLCYLGEENCQVRFAKSALRRKCAVCKIVVHTACIEQLEKINFRCKPTFREGGSRSPRENFVRHHWVHRRRQEGKCKQCGKGFQQKFSFHSKEIVAISCSWCKQAFHNKVTCFMLHHIEEPCSLGAHAAVIVPPTWIIKVKKPQNSLKASNRKKKRTSFKRKASKRGTEQETKGRPFVIKPISSPLMKPLLVFVNPKSGGNQGTKVLQMFMWYLNPRQVFDLSQEGPKDALEMYRKVPNLRILACGGDGTVGWILSILDELQLSPQPPVGVLPLGTGNDLARTLNWGGGYTDEPVSKILCQVEDGTIVQLDRWNLHVERNPDLPPEELEDGVCKLPLNVFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGAAFSDFLQRSSRDLSKHVKVVCDGTDLTPKIQDLKFQCIVFLNIPRYCAGTMPWGNPGDHHDFEPQRHDDGYIEVIGFTMASLAALQVGGHGERLHQCREVMLLTYKSIPMQVDGEPCRLAPAMIRISLRNQANMVQKSKRRTSMPLLNDPQSVPDRLRIRVNKISLQDYEGLHYDKDKLREASIPLGILVVRGDCDLETCRMYIDRLQEDLQSVSSGSQRVHYQDQETSFPRALSAQRLSPRWCFLDATSADRFYRIDRSQACFPPSGTFALCDGDFSR", "length": 841, "header": "tr|S4R2G0-1|S4R2G0_MOUSE Computationally mapped isoform of Diacylglycerol kinase OS=Mus musculus OX=10090 GN=Dgki PE=1 SV=1 CANONICAL=D3YWQ0-1" }, "locus": { "chromosome": "6", "start_pos": 37276883, "end_pos": 36892410, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000138286.8", "url": "https://www.ensembl.org/id/ENSMUST00000138286.8" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000138628.2", "url": "https://www.ensembl.org/id/ENSMUSP00000138628.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Diacylglycerol kinase iota regulates Ras guanyl-releasing protein 3 and inhibits Rap1 signaling.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "2005", "authors": "Prescott S.M., Sakane F., Topham M.K., Higbee J., Lund K.M., Regier D.S.", "evidence": [ { "database": "UniProtKB", "id": "D3YWQ0", "url": "https://www.uniprot.org/uniprot/D3YWQ0" } ], "reference": [ { "type": "PubMed", "id": "15894621", "url": "https://glygen.org/publication/PubMed/15894621" } ] }, { "title": "DGKiota regulates presynaptic release during mGluR-dependent LTD.", "journal": "EMBO J.", "date": "2011", "authors": "Yang J, Seo J, Nair R, Han S, Jang S, Kim K, Han K, Paik SK, Choi J, Lee S, Bae YC, Topham MK, Prescott SM, Rhee JS, Choi SY, Kim E", "evidence": [ { "database": "UniProtKB", "id": "D3YWQ0", "url": "https://www.uniprot.org/uniprot/D3YWQ0" } ], "reference": [ { "type": "PubMed", "id": "21119615", "url": "https://glygen.org/publication/PubMed/21119615" } ] }, { "title": "Mania- and anxiety-like behavior and impaired maternal care in female diacylglycerol kinase eta and iota double knockout mice.", "journal": "Genes, brain, and behavior", "date": "2020", "authors": "Bartsch VB, Lord JS, Diering GH, Zylka MJ", "evidence": [ { "database": "RefSeq", "id": "NP_001334033", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334033" } ], "reference": [ { "type": "PubMed", "id": "30985063", "url": "https://glygen.org/publication/PubMed/30985063" } ] }, { "title": "Enhanced histamine-induced itch in diacylglycerol kinase iota knockout mice.", "journal": "PloS one", "date": "2019", "authors": "Bartsch VB, Niehaus JK, Taylor-Blake B, Zylka MJ", "evidence": [ { "database": "RefSeq", "id": "NP_001334033", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334033" } ], "reference": [ { "type": "PubMed", "id": "31167004", "url": "https://glygen.org/publication/PubMed/31167004" } ] } ], "pathway": [ { "id": "mmu:320127", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:320127", "resource": "KEGG Pathway" }, { "id": "R-MMU-114508", "name": "Effects of PIP2 hydrolysis", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-114508", "resource": "Reactome", "description": "Effects of PIP2 hydrolysis" } ], "orthologs": [ { "uniprot_canonical_ac": "F1MAB7-1", "protein_name": "Diacylglycerol kinase iota", "gene_name": "Dgki", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": 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"https://www.uniprot.org/uniprot/D3YWQ0" } ], "pmid": "" }, { "name": "positive regulation of Ras protein signal transduction", "id": "GO:0046579", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046579", "evidence": [ { "database": "UniProtKB", "id": "D3YWQ0", "url": "https://www.uniprot.org/uniprot/D3YWQ0" } ], "pmid": "" }, { "name": "diacylglycerol metabolic process", "id": "GO:0046339", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046339", "evidence": [ { "database": "UniProtKB", "id": "D3YWQ0", "url": "https://www.uniprot.org/uniprot/D3YWQ0" } ], "pmid": "" }, { "name": "habituation", "id": "GO:0046959", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046959", "evidence": [ { "database": "UniProtKB", "id": "D3YWQ0", "url": "https://www.uniprot.org/uniprot/D3YWQ0" } ], "pmid": "" }, { "name": "regulation of long-term synaptic depression", "id": "GO:1900452", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1900452", "evidence": [ { "database": "UniProtKB", "id": "D3YWQ0", "url": "https://www.uniprot.org/uniprot/D3YWQ0" } ], "pmid": "" }, { "name": "phosphatidic acid biosynthetic process", "id": "GO:0006654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006654", "evidence": [ { "database": "UniProtKB", "id": "D3YWQ0", "url": "https://www.uniprot.org/uniprot/D3YWQ0" } ], "pmid": "" }, { "name": "intracellular signal transduction", "id": "GO:0035556", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035556", "evidence": [ { "database": "UniProtKB", "id": "D3YWQ0", "url": "https://www.uniprot.org/uniprot/D3YWQ0" } ], "pmid": "" }, { "name": "regulation of GTPase activity", "id": "GO:0043087", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043087", "evidence": [ { "database": "UniProtKB", "id": "D3YWQ0", "url": "https://www.uniprot.org/uniprot/D3YWQ0" } ], "pmid": "" }, { "name": "excitatory postsynaptic potential", "id": "GO:0060079", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060079", "evidence": [ { "database": "UniProtKB", "id": "D3YWQ0", "url": "https://www.uniprot.org/uniprot/D3YWQ0" } ], "pmid": "" }, { "name": "Ras protein signal transduction", "id": "GO:0007265", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007265", "evidence": [ { "database": "UniProtKB", "id": "D3YWQ0", "url": "https://www.uniprot.org/uniprot/D3YWQ0" } ], "pmid": "" }, { "name": "neurotransmitter secretion", "id": "GO:0007269", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007269", "evidence": [ { "database": "UniProtKB", "id": "D3YWQ0", "url": "https://www.uniprot.org/uniprot/D3YWQ0" } ], "pmid": "" }, { "name": "regulation of synaptic transmission, glutamatergic", "id": "GO:0051966", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051966", "evidence": [ { "database": "UniProtKB", "id": "D3YWQ0", "url": "https://www.uniprot.org/uniprot/D3YWQ0" } ], "pmid": "" }, { "name": "presynaptic modulation of chemical synaptic transmission", "id": "GO:0099171", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0099171", "evidence": [ { "database": "UniProtKB", "id": "D3YWQ0", "url": "https://www.uniprot.org/uniprot/D3YWQ0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "ATP-dependent diacylglycerol kinase activity", "id": "GO:0004143", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004143", "evidence": [ { "database": "UniProtKB", "id": "D3YWQ0", "url": "https://www.uniprot.org/uniprot/D3YWQ0" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "D3YWQ0", "url": "https://www.uniprot.org/uniprot/D3YWQ0" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "D3YWQ0", "url": "https://www.uniprot.org/uniprot/D3YWQ0" } ], "pmid": "" }, { "name": "GTPase inhibitor activity", "id": "GO:0005095", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005095", "evidence": [ { "database": "UniProtKB", "id": "D3YWQ0", "url": "https://www.uniprot.org/uniprot/D3YWQ0" } ], "pmid": "" }, { "name": "small GTPase binding", "id": "GO:0031267", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031267", "evidence": [ { "database": "UniProtKB", "id": "D3YWQ0", "url": "https://www.uniprot.org/uniprot/D3YWQ0" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 20, "go_terms": [ { "name": "glutamatergic synapse", "id": "GO:0098978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098978", "evidence": [ { "database": "UniProtKB", "id": "D3YWQ0", "url": "https://www.uniprot.org/uniprot/D3YWQ0" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "D3YWQ0", "url": "https://www.uniprot.org/uniprot/D3YWQ0" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "D3YWQ0", "url": "https://www.uniprot.org/uniprot/D3YWQ0" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "D3YWQ0", "url": "https://www.uniprot.org/uniprot/D3YWQ0" } ], "pmid": "" }, { "name": "postsynaptic density", "id": "GO:0014069", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0014069", "evidence": [ { "database": "UniProtKB", "id": "D3YWQ0", "url": "https://www.uniprot.org/uniprot/D3YWQ0" } ], "pmid": "" }, { "name": "neuronal cell body", "id": "GO:0043025", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043025", "evidence": [ { "database": "UniProtKB", "id": "D3YWQ0", "url": "https://www.uniprot.org/uniprot/D3YWQ0" } ], "pmid": "" }, { "name": "dendritic spine", "id": "GO:0043197", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043197", "evidence": [ { "database": "UniProtKB", "id": "D3YWQ0", "url": "https://www.uniprot.org/uniprot/D3YWQ0" } ], "pmid": "" }, { "name": "axon terminus", "id": "GO:0043679", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043679", "evidence": [ { "database": "UniProtKB", "id": "D3YWQ0", "url": "https://www.uniprot.org/uniprot/D3YWQ0" } ], "pmid": "" }, { "name": "synapse", "id": "GO:0045202", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045202", "evidence": [ { "database": "UniProtKB", "id": "D3YWQ0", "url": "https://www.uniprot.org/uniprot/D3YWQ0" } ], "pmid": "" }, { "name": "perinuclear region of cytoplasm", "id": "GO:0048471", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471", "evidence": [ { "database": "UniProtKB", "id": "D3YWQ0", "url": "https://www.uniprot.org/uniprot/D3YWQ0" } ], "pmid": "" }, { "name": "presynaptic active zone", "id": "GO:0048786", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048786", "evidence": [ { "database": "UniProtKB", "id": "D3YWQ0", "url": "https://www.uniprot.org/uniprot/D3YWQ0" } ], "pmid": "" }, { "name": "synaptic vesicle membrane", "id": "GO:0030672", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030672", "evidence": [ { "database": "UniProtKB", "id": "D3YWQ0", "url": "https://www.uniprot.org/uniprot/D3YWQ0" } ], "pmid": "" }, { "name": "synaptic membrane", "id": "GO:0097060", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097060", "evidence": [ { "database": "UniProtKB", "id": "D3YWQ0", "url": "https://www.uniprot.org/uniprot/D3YWQ0" } ], "pmid": "" }, { "name": "synaptic vesicle", "id": "GO:0008021", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008021", "evidence": [ { "database": "UniProtKB", "id": "D3YWQ0", "url": "https://www.uniprot.org/uniprot/D3YWQ0" } ], "pmid": "" }, { "name": "protein-containing complex", "id": "GO:0032991", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032991", "evidence": [ { "database": "UniProtKB", "id": "D3YWQ0", "url": "https://www.uniprot.org/uniprot/D3YWQ0" } ], "pmid": "" }, { "name": "excitatory synapse", "id": "GO:0060076", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060076", "evidence": [ { "database": "UniProtKB", "id": "D3YWQ0", "url": "https://www.uniprot.org/uniprot/D3YWQ0" } ], "pmid": "" }, { "name": "extrinsic component of presynaptic active zone membrane", "id": "GO:0098891", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098891", "evidence": [ { "database": "UniProtKB", "id": "D3YWQ0", "url": "https://www.uniprot.org/uniprot/D3YWQ0" } ], "pmid": "" }, { "name": "guanyl-nucleotide exchange factor complex", "id": "GO:0032045", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032045", "evidence": [ { "database": "UniProtKB", "id": "D3YWQ0", "url": "https://www.uniprot.org/uniprot/D3YWQ0" } ], "pmid": "" }, { "name": "Schaffer collateral - CA1 synapse", "id": "GO:0098685", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098685", "evidence": [ { "database": "UniProtKB", "id": "D3YWQ0", "url": "https://www.uniprot.org/uniprot/D3YWQ0" } ], "pmid": "" }, { "name": "extrinsic component of postsynaptic density membrane", "id": "GO:0099147", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0099147", "evidence": [ { "database": "UniProtKB", "id": "D3YWQ0", "url": "https://www.uniprot.org/uniprot/D3YWQ0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 179, "end_pos": 181, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "10272", "name": "", "equation": "a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O08560-1", "F1LZW2-1", "D3ZEY4-1", "P51556-1", "P49620-1", "P49621-1", "A0A096UWG9-1", "F1MAB7-1", "D3ZSZ6-1", "F1M5T2-1", "D3Z9L0-1", "P52429-1", "Q53H12-1", "Q86XP1-1", "O75912-1", "P52824-1", "P49619-1", "Q16760-1", "Q5KSL6-1", "Q9Y6T7-1", "P23743-1", "Q13574-2", "Q91WG7-1", "D3YXJ0-1", "D3YWQ0-1", "Q9ESW4-1", "Q9R1C6-1", "O88673-1", "Q80UP3-1", "Q6P5E8-1", "Q6NS52-1", "E9PUQ8-1", "F6UUZ3-1", "P34125-1", "Q9VL10-1", "Q01583-4", "Q09103-1", "A8JQ65-1", "A0A0B4KHZ4-1", "Q7K579-1" ], "evidence": [ { "id": "10272", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/10272" } ] }, { "id": "40323", "name": "", "equation": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O08560-1", "P51556-1", "P49620-1", "P49621-1", "D3ZEY4-1", "F1MAB7-1", "O75912-1", "Q9Y6T7-1", "Q16760-1", "P52429-1", "P49619-1", "P52824-1", "P23743-1", "Q13574-2", "D3YWQ0-1", "Q80UP3-1", "O88673-1", "Q91WG7-1", "Q9R1C6-1", "Q6P5E8-1", "Q6NS52-1", "E9PUQ8-1" ], "evidence": [ { "id": "40323", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/40323" } ] }, { "id": "40327", "name": "", "equation": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + ATP = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O08560-1", "P51556-1", "P49620-1", "P49621-1", "A0A096UWG9-1", "F1LZW2-1", "F1MAB7-1", "D3ZSZ6-1", "F1M5T2-1", "D3ZEY4-1", "D3Z9L0-1", "Q53H12-1", "O75912-1", "P52824-1", "P23743-1", "P52429-1", "Q86XP1-1", "Q9Y6T7-1", "Q16760-1", "P49619-1", "Q5KSL6-1", "Q13574-2", "Q9ESW4-1", "O88673-1", "Q80UP3-1", "D3YWQ0-1", "D3YXJ0-1", "Q91WG7-1", "Q9R1C6-1", "Q6P5E8-1", "Q6NS52-1", "E9PUQ8-1", "F6UUZ3-1", "Q9VL10-1" ], "evidence": [ { "id": "40327", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/40327" } ] }, { "id": "40339", "name": "", "equation": "1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycerol + ATP = 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P49620-1", "P49621-1", "F1MAB7-1", "O75912-1", "P52429-1", "P49619-1", "Q9Y6T7-1", "Q91WG7-1", "Q9R1C6-1", "Q6NS52-1", "D3YWQ0-1" ], "evidence": [ { "id": "40339", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/40339" } ] }, { "id": "R-MMU-426240", "name": "DAG kinase produces phosphatidic acid from DAG", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [ "R-ALL-76108" ], "enzyme_list": [ "O88673-1", "Q91WG7-1", "E9PUQ8-1", "Q6NS52-1", "Q6P5E8-1", "D3YWQ0-1", "Q80UP3-1", "Q9R1C6-1", "D3YXJ0-1", "F6UUZ3-1" ], "evidence": [ { "id": "R-MMU-426240", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-426240" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-76108", "participant_name": "1,2-daG3P [cytosol]", "crossref": [ { "id": "C00416", "database": "COMPOUND", "url": "" }, { "id": "29089", "database": "ChEBI", "url": "" }, { "id": "C00416", "database": "COMPOUND", "url": "" }, { "id": "29089", "database": "ChEBI", "url": "" }, { "id": "C00416", "database": "COMPOUND", "url": "" }, { "id": "29089", "database": "ChEBI", "url": "" }, { "id": "C00416", "database": "COMPOUND", "url": "" }, { "id": "29089", "database": "ChEBI", "url": "" }, { "id": "C00416", "database": "COMPOUND", "url": "" }, { "id": "29089", "database": "ChEBI", "url": "" }, { "id": "C00416", "database": "COMPOUND", "url": "" }, { "id": "29089", "database": "ChEBI", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0A096UWG9", "gene_name": "Dgke", "activity": [ { "ec_number": "2.7.1.107", "activity": "a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+).", "evidence": [ { "id": "A0A096UWG9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A096UWG9" } ] }, { "ec_number": "2.7.1.107", "activity": "", "evidence": [ { "id": "A0A096UWG9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A096UWG9" } ] } ] }, { "uniprot_ac": "A0A0B4KHZ4", "gene_name": "Dmel\\CG31140", "activity": [ { "ec_number": "2.7.1.107", "activity": "a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+).", "evidence": [ { "id": "A0A0B4KHZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0B4KHZ4" } ] }, { "ec_number": "2.7.1.23", "activity": "ATP + NAD(+) = ADP + H(+) + NADP(+).", "evidence": [ { "id": "A0A0B4KHZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0B4KHZ4" } ] }, { "ec_number": "2.7.1.107", "activity": "", "evidence": [ { "id": "A0A0B4KHZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0B4KHZ4" } ] } ] }, { "uniprot_ac": "A8JQ65", "gene_name": "", "activity": [ { "ec_number": "2.7.1.107", "activity": "a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+).", "evidence": [ { "id": "A8JQ65", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A8JQ65" } ] }, { "ec_number": "2.7.1.107", "activity": "", "evidence": [ { "id": "A8JQ65", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A8JQ65" } ] } ] }, { "uniprot_ac": "D3YWQ0", "gene_name": "Dgki", "activity": [ { "ec_number": "2.7.1.107", "activity": "a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+).", "evidence": [ { "id": "D3YWQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3YWQ0" } ] }, { "ec_number": "2.7.1.107", "activity": "", "evidence": [ { "id": "D3YWQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3YWQ0" } ] } ] }, { "uniprot_ac": "D3YXJ0", "gene_name": "Dgkh", "activity": [ { "ec_number": "2.7.1.107", "activity": "a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+).", "evidence": [ { "id": "D3YXJ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3YXJ0" } ] }, { "ec_number": "2.7.1.107", "activity": "", "evidence": [ { "id": "D3YXJ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3YXJ0" } ] } ] }, { "uniprot_ac": "D3Z9L0", "gene_name": "Agk", "activity": [ { "ec_number": "2.7.1.107", "activity": "a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+).", "evidence": [ { "id": "D3Z9L0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3Z9L0" } ] }, { "ec_number": "2.7.1.94", "activity": "a monoacylglycerol + ATP = ADP + H(+) + monoacyl-sn-glycero-3-phosphate.", "evidence": [ { "id": "D3Z9L0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3Z9L0" } ] }, { "ec_number": "2.7.1.138", "activity": "an N-acylsphing-4-enine + ATP = ADP + an N-acylsphing-4-enine 1-phosphate + H(+).", "evidence": [ { "id": "D3Z9L0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3Z9L0" } ] }, { "ec_number": "2.7.1.94", "activity": "", "evidence": [ { "id": "D3Z9L0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3Z9L0" } ] }, { "ec_number": "2.7.1.138", "activity": "", "evidence": [ { "id": "D3Z9L0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3Z9L0" } ] }, { "ec_number": "2.7.1.107", "activity": "", "evidence": [ { "id": "D3Z9L0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3Z9L0" } ] } ] }, { "uniprot_ac": "D3ZEY4", "gene_name": "Dgkq", "activity": [ { "ec_number": "2.7.1.107", "activity": "a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+).", "evidence": [ { "id": "D3ZEY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZEY4" } ] }, { "ec_number": "2.7.1.107", "activity": "", "evidence": [ { "id": "D3ZEY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZEY4" } ] } ] }, { "uniprot_ac": "D3ZSZ6", "gene_name": "Dgkh", "activity": [ { "ec_number": "2.7.1.107", "activity": "a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+).", "evidence": [ { "id": "D3ZSZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZSZ6" } ] }, { "ec_number": "2.7.1.107", "activity": "", "evidence": [ { "id": "D3ZSZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZSZ6" } ] } ] }, { "uniprot_ac": "E9PUQ8", "gene_name": "Dgkd", "activity": [ { "ec_number": "2.7.1.107", "activity": "a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+).", "evidence": [ { "id": "E9PUQ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9PUQ8" } ] }, { "ec_number": "2.7.1.107", "activity": "", "evidence": [ { "id": "E9PUQ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9PUQ8" } ] } ] }, { "uniprot_ac": "F1LZW2", "gene_name": "Dgkk", "activity": [ { "ec_number": "2.7.1.107", "activity": "a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+).", "evidence": [ { "id": "F1LZW2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LZW2" } ] }, { "ec_number": "2.7.1.107", "activity": "", "evidence": [ { "id": "F1LZW2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LZW2" } ] } ] }, { "uniprot_ac": "F1M5T2", "gene_name": "Dgkd", "activity": [ { "ec_number": "2.7.1.107", "activity": "a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+).", "evidence": [ { "id": "F1M5T2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1M5T2" } ] }, { "ec_number": "2.7.1.107", "activity": "", "evidence": [ { "id": "F1M5T2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1M5T2" } ] } ] }, { "uniprot_ac": "F1MAB7", "gene_name": "Dgki", "activity": [ { "ec_number": "2.7.1.107", "activity": "a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+).", "evidence": [ { "id": "F1MAB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1MAB7" } ] }, { "ec_number": "2.7.1.107", "activity": "", "evidence": [ { "id": "F1MAB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1MAB7" } ] } ] }, { "uniprot_ac": "F6UUZ3", "gene_name": "Dgkk", "activity": [ { "ec_number": "2.7.1.107", "activity": "a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+).", "evidence": [ { "id": "F6UUZ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F6UUZ3" } ] }, { "ec_number": "2.7.1.107", "activity": "", "evidence": [ { "id": "F6UUZ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F6UUZ3" } ] } ] }, { "uniprot_ac": "O08560", "gene_name": "Dgkz", "activity": [ { "ec_number": "2.7.1.107", "activity": "a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+).", "evidence": [ { "id": "O08560", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08560" } ] }, { "ec_number": "2.7.1.107", "activity": "", "evidence": [ { "id": "O08560", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08560" } ] } ] }, { "uniprot_ac": "O75912", "gene_name": "DGKI", "activity": [ { "ec_number": "2.7.1.107", "activity": "a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+).", "evidence": [ { "id": "O75912", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75912" } ] }, { "ec_number": "2.7.1.107", "activity": "", "evidence": [ { "id": "O75912", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75912" } ] } ] }, { "uniprot_ac": "O88673", "gene_name": "Dgka", "activity": [ { "ec_number": "2.7.1.107", "activity": "a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+).", "evidence": [ { "id": "O88673", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88673" } ] }, { "ec_number": "2.7.1.107", "activity": "", "evidence": [ { "id": "O88673", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88673" } ] } ] }, { "uniprot_ac": "P23743", "gene_name": "DGKA", "activity": [ { "ec_number": "2.7.1.107", "activity": "a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+).", "evidence": [ { "id": "P23743", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23743" } ] }, { "ec_number": "2.7.1.107", "activity": "", "evidence": [ { "id": "P23743", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23743" } ] } ] }, { "uniprot_ac": "P34125", "gene_name": "dgkA", "activity": [ { "ec_number": "2.7.1.107", "activity": "a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+).", "evidence": [ { "id": "P34125", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P34125" } ] }, { "ec_number": "2.7.1.107", "activity": "", "evidence": [ { "id": "P34125", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P34125" } ] } ] }, { "uniprot_ac": "P49619", "gene_name": "DGKG", "activity": [ { "ec_number": "2.7.1.107", "activity": "a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+).", "evidence": [ { "id": "P49619", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49619" } ] }, { "ec_number": "2.7.1.107", "activity": "", "evidence": [ { "id": "P49619", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49619" } ] } ] }, { "uniprot_ac": "P49620", "gene_name": "Dgkg", "activity": [ { "ec_number": "2.7.1.107", "activity": "a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+).", "evidence": [ { "id": "P49620", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49620" } ] }, { "ec_number": "2.7.1.107", "activity": "", "evidence": [ { "id": "P49620", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49620" } ] } ] }, { "uniprot_ac": "P49621", "gene_name": "Dgkb", "activity": [ { "ec_number": "2.7.1.107", "activity": "a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+).", "evidence": [ { "id": "P49621", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49621" } ] }, { "ec_number": "2.7.1.107", "activity": "", "evidence": [ { "id": "P49621", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49621" } ] } ] }, { "uniprot_ac": "P51556", 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