{
    "uniprot_canonical_ac": "B2ZDP9-1",
    "uniprot_ac": "B2ZDP9",
    "uniprot_id": "B2ZDP9_RAT",
    "mass": {
        "chemical_mass": 34475.0,
        "monoisotopic_mass": 34475.0
    },
    "refseq": {
        "ac": "NP_001163874",
        "name": "protein orai-2",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001163874"
    },
    "gene_names": [
        {
            "name": "Orai2",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/B2ZDP9",
            "id": "B2ZDP9"
        },
        {
            "name": "ORAI2",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/B2ZDP9",
            "id": "B2ZDP9"
        },
        {
            "name": "Orai2",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001163874",
            "id": "NP_001163874"
        },
        {
            "name": "RGD1310213",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001163874",
            "id": "NP_001163874"
        }
    ],
    "protein_names": [
        {
            "name": "Calcium release-activated calcium modulator 2 protein",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "B2ZDP9"
        },
        {
            "name": "ORAI calcium release-activated calcium modulator 2",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "B2ZDP9"
        },
        {
            "name": "calcium release-activated calcium modulator 2 protein; CAP-binding protein complex interacting protein 2",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001163874",
            "id": "NP_001163874"
        },
        {
            "name": "protein orai-2",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001163874",
            "id": "NP_001163874"
        }
    ],
    "function": [
        {
            "annotation": "Orai-2 is localized on secretory granules in mast cells.Orai-2 regulates degranulation by affecting Ca release from Ca store.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001163874",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001163874"
                },
                {
                    "database": "PubMed",
                    "id": "25044118",
                    "url": "https://glygen.org/publication/PubMed/25044118"
                }
            ]
        }
    ],
    "disease": [
        {
            "disease_id": "DOID:11984",
            "recommended_name": {
                "id": "DOID:11984",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:11984",
                "name": "hypertrophic cardiomyopathy",
                "description": "An intrinsic cardiomyopathy that is characterized by abnormal thickening (hypertrophy) of the heart without any obvious cause."
            },
            "synonyms": [
                {
                    "id": "DOID:11984",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:11984",
                    "name": "hypertrophic obstructive cardiomyopathy",
                    "description": ""
                }
            ],
            "evidence": [
                {
                    "id": "11984",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:11984"
                }
            ]
        },
        {
            "disease_id": "DOID:12930",
            "recommended_name": {
                "id": "DOID:12930",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:12930",
                "name": "dilated cardiomyopathy",
                "description": "An intrinsic cardiomyopathy that is characterized by an an enlarged heart and damage to the myocardium causing the heart to pump blood inefficiently."
            },
            "synonyms": [
                {
                    "id": "DOID:12930",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:12930",
                    "name": "primary dilated cardiomyopathy",
                    "description": ""
                },
                {
                    "id": "MONDO:0007269",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007269",
                    "name": "dilated cardiomyopathy 1A",
                    "description": "Familial dilated cardiomyopathy with conduction defect due to LMNA mutation is a rare familial dilated cardiomyopathy characterized by left ventricular enlargement and/or reduced systolic function preceded or accompanied by significant conduction system disease and/or arrhythmias including bradyarrhythmias, supraventricular or ventricular arrhythmias. Disease onset is usually in early to mid-adulthood. Sudden cardiac death may occur and may be the presenting symptom. In some cases, it is associated with skeletal myopathy and elevated serum creatine kinase."
                },
                {
                    "id": "MONDO:0007269",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007269",
                    "name": "CDCD1",
                    "description": ""
                },
                {
                    "id": "MONDO:0007269",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007269",
                    "name": "LMNA familial isolated dilated cardiomyopathy",
                    "description": ""
                },
                {
                    "id": "MONDO:0007269",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007269",
                    "name": "cardiomyopathy dilated with conduction defect type 1",
                    "description": ""
                },
                {
                    "id": "MONDO:0007269",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007269",
                    "name": "cardiomyopathy, dilated, type 1A",
                    "description": ""
                },
                {
                    "id": "MONDO:0007269",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007269",
                    "name": "dilated cardiomyopathy 1A",
                    "description": ""
                },
                {
                    "id": "MONDO:0007269",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007269",
                    "name": "dilated cardiomyopathy type 1A",
                    "description": ""
                },
                {
                    "id": "MONDO:0007269",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007269",
                    "name": "dilated cardiomyopathy with conduction defect 1",
                    "description": ""
                },
                {
                    "id": "MONDO:0007269",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007269",
                    "name": "familial dilated cardiomyopathy with conduction defect due to LMNA mutation",
                    "description": ""
                },
                {
                    "id": "MONDO:0007269",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007269",
                    "name": "familial isolated dilated cardiomyopathy caused by mutation in LMNA",
                    "description": ""
                },
                {
                    "id": "MONDO:0007269",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007269",
                    "name": "cardiomyopathy, congestive",
                    "description": ""
                },
                {
                    "id": "MONDO:0007269",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007269",
                    "name": "cardiomyopathy, dilated, 1A",
                    "description": ""
                },
                {
                    "id": "MONDO:0007269",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007269",
                    "name": "cardiomyopathy, dilated, with conduction defect 1",
                    "description": ""
                },
                {
                    "id": "MONDO:0007269",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007269",
                    "name": "cardiomyopathy, familial idiopathic",
                    "description": ""
                },
                {
                    "id": "MONDO:0007269",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007269",
                    "name": "cardiomyopathy, idiopathic dilated",
                    "description": ""
                },
                {
                    "id": "MIM:115200",
                    "resource": "MIM",
                    "url": "https://www.omim.org/entry/115200",
                    "name": "Cardiomyopathy, dilated, 1A",
                    "description": "Cardiomyopathy, dilated, 1A"
                }
            ],
            "evidence": [
                {
                    "id": "12930",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:12930"
                }
            ]
        }
    ],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Rattus norvegicus",
            "taxid": 10116,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "B2ZDP9",
                    "url": "https://www.uniprot.org/uniprot/B2ZDP9"
                }
            ],
            "common_name": "Rat"
        }
    ],
    "gene": [
        {
            "name": "Orai2",
            "url": "https://www.uniprot.org/uniprot/B2ZDP9",
            "locus": {
                "chromosome": "12",
                "start_pos": 20520428,
                "end_pos": 20497317,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSRNOG00000001427",
                        "url": "https://www.ensembl.org/id/ENSRNOG00000001427"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSRNOG00000001427",
            "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000001427",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "304592",
            "url": "https://www.ncbi.nlm.nih.gov/gene/304592",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "IPR012446",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR012446",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR038350",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR038350",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "rno:304592",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:304592",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "VYIELAW",
            "url": "https://omabrowser.org/oma/group/VYIELAW/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "2905973at2759",
            "url": "http://www.orthodb.org/?query=2905973at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR31501",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31501",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR31501:SF5",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31501:SF5",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF07856",
            "url": "http://pfam.xfam.org/family/PF07856",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "NP_001163874",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001163874",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "1310213",
            "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1310213",
            "database": "RGD",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "B2ZDP9",
            "url": "https://www.uniprot.org/uniprot/B2ZDP9",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "B2ZDP9-1",
            "url": "https://www.uniprot.org/uniprot/B2ZDP9-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "F7EZ46",
            "url": "https://www.uniprot.org/uniprot/F7EZ46",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "F7EZ46-1",
            "url": "https://www.uniprot.org/uniprot/F7EZ46-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MGHVTAAQRCLGSGCGRKEGGGRSSALARLPGHPAPTQTLATSRSGELEPSALRASQPGLVPTMSAELNVPMDPSAPACPEPGHKGMDYRDWVRRSYLELVTSNHHSVQALSWRKLYLSRAKLKASSRTSALLSGFAMVAMVEVQLETKYQYPQPLLIAFSACTTVLVAVHLFALLISTCILPNVEAVSNIHNLNSISESPHERMHPYIELAWGFSTVLGILLFLAEVVLLCWIKFLPVDAKDQPGSHSHTGWQAALVSTIIMVPVGLIFVVFTIHFYRSLVRHKTERHNREIEELHKLKVQLDGHERSLQVV",
        "length": 313,
        "header": "tr|B2ZDP9-1|B2ZDP9_RAT Isoform 1 of Calcium release-activated calcium modulator 2 protein  OS=Rattus norvegicus OX=10116 GN=Orai2 PE=2 SV=1 CANONICAL=B2ZDP9-1"
    },
    "isoforms": [
        {
            "isoform_ac": "B2ZDP9-1",
            "url": "",
            "sequence": {
                "sequence": "MGHVTAAQRCLGSGCGRKEGGGRSSALARLPGHPAPTQTLATSRSGELEPSALRASQPGLVPTMSAELNVPMDPSAPACPEPGHKGMDYRDWVRRSYLELVTSNHHSVQALSWRKLYLSRAKLKASSRTSALLSGFAMVAMVEVQLETKYQYPQPLLIAFSACTTVLVAVHLFALLISTCILPNVEAVSNIHNLNSISESPHERMHPYIELAWGFSTVLGILLFLAEVVLLCWIKFLPVDAKDQPGSHSHTGWQAALVSTIIMVPVGLIFVVFTIHFYRSLVRHKTERHNREIEELHKLKVQLDGHERSLQVV",
                "length": 313,
                "header": "tr|B2ZDP9-1|B2ZDP9_RAT Isoform 1 of Calcium release-activated calcium modulator 2 protein  OS=Rattus norvegicus OX=10116 GN=Orai2 PE=2 SV=1 CANONICAL=B2ZDP9-1"
            },
            "locus": {
                "chromosome": "12",
                "start_pos": 20517320,
                "end_pos": 20500308,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000110615.1",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000110615.1"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000085810.1",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000085810.1"
                    }
                ]
            }
        },
        {
            "isoform_ac": "F7EZ46-1",
            "url": "",
            "sequence": {
                "sequence": "VKEGRTHRHGLVPTMSAELNVPMDPSAPACPEPGHKGMDYRDWVRRSYLELVTSNHHSVQALSWRKLYLSRAKLKASSRTSALLSGFAMVAMVEVQLETKYQYPQPLLIAFSACTTVLVAVHLFALLISTCILPNVEAVSNIHNLNSISESPHERMHPYIELAWGFSTVLGILLFLAEVVLLCWIKFLPVDAKDQPGSHSHTGWQAALVSTIIMVPVGLIFVVFTIHFYRSLVRHKTERHNREIEELHKLKVQLDGHERSLQVV",
                "length": 264,
                "header": "tr|F7EZ46-1|F7EZ46_RAT Computationally mapped isoform of ORAI calcium release-activated calcium modulator 2  OS=Rattus norvegicus OX=10116 GN=Orai2 PE=3 SV=1 CANONICAL=B2ZDP9-1"
            },
            "locus": {
                "chromosome": "12",
                "start_pos": 20517320,
                "end_pos": 20503023,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000001938.7",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000001938.7"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000001938.5",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000001938.5"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [],
    "publication": [
        {
            "title": "Orai-2 is localized on secretory granules and regulates antigen-evoked Ca(2)(+) mobilization and exocytosis in mast cells.",
            "journal": "Biochemical and biophysical research communications",
            "date": "2014",
            "authors": "Ikeya M, Yamanoue K, Mochizuki Y, Konishi H, Tadokoro S, Tanaka M, Suzuki R, Hirashima N",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001163874",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001163874"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "25044118",
                    "url": "https://glygen.org/publication/PubMed/25044118"
                }
            ]
        }
    ],
    "pathway": [
        {
            "id": "rno:304592",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:304592",
            "resource": "KEGG Pathway"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "Q8BH10-1",
            "protein_name": "Protein orai-2",
            "gene_name": "Orai2",
            "tax_id": 10090,
            "organism": "Mus musculus",
            "sequence": {
                "sequence": "MSAELNVPMDPSAPACPEPGHKGMDYRDWVRRSYLELVTSNHHSVQALSWRKLYLSRAKLKASSRTSALLSGFAMVAMVEVQLETKYQYPQPLLIAFSACTTVLVAVHLFALLISTCILPNVEAVSNIHNLNSISESPHERMHPYIELAWGFSTVLGILLFLAEVVLLCWIKFLPVDAKDQPGSHSHTGWQAALVSTIIMVPVGLIFVVFTIHFYRSLVRHKTERHNREIEELHKLKVQLDGHERSLQVV",
                "length": 250
            },
            "evidence": [
                {
                    "id": "45238379",
                    "url": "http://www.informatics.jax.org/homology/45238379",
                    "database": "MGI"
                }
            ],
            "common_name": "Mouse"
        },
        {
            "uniprot_canonical_ac": "Q96SN7-1",
            "protein_name": "Protein orai-2",
            "gene_name": "ORAI2",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MSAELNVPIDPSAPACPEPGHKGMDYRDWVRRSYLELVTSNHHSVQALSWRKLYLSRAKLKASSRTSALLSGFAMVAMVEVQLETQYQYPRPLLIAFSACTTVLVAVHLFALLISTCILPNVEAVSNIHNLNSISESPHERMHPYIELAWGFSTVLGILLFLAEVVLLCWIKFLPVDARRQPGPPPGPGSHTGWQAALVSTIIMVPVGLIFVVFTIHFYRSLVRHKTERHNREIEELHKLKVQLDGHERSLQVL",
                "length": 254
            },
            "evidence": [
                {
                    "id": "45238379",
                    "url": "http://www.informatics.jax.org/homology/45238379",
                    "database": "MGI"
                }
            ],
            "common_name": "Human"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Cellular Component",
                "total": 2,
                "go_terms": [
                    {
                        "name": "membrane",
                        "id": "GO:0016020",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "B2ZDP9",
                                "url": "https://www.uniprot.org/uniprot/B2ZDP9"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "growth cone",
                        "id": "GO:0030426",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030426",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "B2ZDP9",
                                "url": "https://www.uniprot.org/uniprot/B2ZDP9"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Biological Process",
                "total": 1,
                "go_terms": [
                    {
                        "name": "store-operated calcium entry",
                        "id": "GO:0002115",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002115",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "B2ZDP9",
                                "url": "https://www.uniprot.org/uniprot/B2ZDP9"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Molecular Function",
                "total": 1,
                "go_terms": [
                    {
                        "name": "store-operated calcium channel activity",
                        "id": "GO:0015279",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015279",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "B2ZDP9",
                                "url": "https://www.uniprot.org/uniprot/B2ZDP9"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            }
        ]
    },
    "pro_annotation": [],
    "site_annotation": [],
    "ptm_annotation": [],
    "interactions": [],
    "reactions": [],
    "reaction_participants": [],
    "reaction_enzymes": [],
    "biomarkers": [],
    "synthesized_glycans": [],
    "cluster_types": [
        {
            "name": "isoformset.uniprotkb",
            "label": "Isoforms"
        },
        {
            "name": "homologset.mgi",
            "label": "MGI Homologs"
        }
    ],
    "section_stats": [
        {
            "table_id": "glycosylation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_reported",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
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                {
                    "field": "n_linked_glycans",
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                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
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