{
    "uniprot_canonical_ac": "B2RZ42-1",
    "uniprot_ac": "B2RZ42",
    "uniprot_id": "ALKL2_RAT",
    "mass": {
        "chemical_mass": 17428.0,
        "monoisotopic_mass": 17428.0
    },
    "refseq": {},
    "gene_names": [
        {
            "name": "Alkal2",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/B2RZ42",
            "id": "B2RZ42"
        }
    ],
    "protein_names": [
        {
            "name": "ALK and LTK ligand 2",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "",
            "id": "B2RZ42"
        }
    ],
    "function": [
        {
            "annotation": "Cytokine that acts as a physiological ligand for receptor tyrosine kinases LTK and ALK, leading to their activation. Cytokine-binding is sufficient to activate LTK. In contrast, ALKAL2-driven activation of ALK is coupled with heparin-binding to ALK. Stimulation of ALK signaling is involved in neural development and regulation of energy expenditure.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "B2RZ42",
                    "url": "https://www.uniprot.org/uniprot/B2RZ42#function"
                },
                {
                    "database": "UniProtKB",
                    "id": "Q6UX46",
                    "url": "https://www.uniprot.org/uniprot/Q6UX46#function"
                }
            ]
        }
    ],
    "disease": [],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Rattus norvegicus",
            "taxid": 10116,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "B2RZ42",
                    "url": "https://www.uniprot.org/uniprot/B2RZ42"
                }
            ],
            "common_name": "Rat"
        }
    ],
    "gene": [
        {
            "name": "Alkal2",
            "url": "https://www.uniprot.org/uniprot/B2RZ42",
            "locus": {
                "chromosome": "6",
                "start_pos": 47505234,
                "end_pos": 47495782,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSRNOG00000005154",
                        "url": "https://www.ensembl.org/id/ENSRNOG00000005154"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSRNOG00000005154",
            "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000005154",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "IPR029364",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR029364",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "rno:679566",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:679566",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "KHDYTLG",
            "url": "https://omabrowser.org/oma/group/KHDYTLG/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "5342509at2759",
            "url": "http://www.orthodb.org/?query=5342509at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR28676",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28676",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR28676:SF2",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28676:SF2",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF15129",
            "url": "http://pfam.xfam.org/family/PF15129",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PR_B2RZ42",
            "url": "http://purl.obolibrary.org/obo/PR_B2RZ42",
            "database": "PRO",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "1587117",
            "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1587117",
            "database": "RGD",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "B2RZ42",
            "url": "https://www.uniprot.org/uniprot/B2RZ42",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "B2RZ42-1",
            "url": "https://www.uniprot.org/uniprot/B2RZ42-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MRVSGRPMLLALLLLLSTVGDPGHAQPRGPADRQTLLRLLVELVQELKKFHIGDSKRLQLLGESDFALGRREATDYGADQEEQRVEIVPRDLRMKDKFLKHLTGPLYFSPKCSKHFHRLYHNTRDCTIPAYYKRCARLLTRLAVSPMCMER",
        "length": 151,
        "header": "sp|B2RZ42-1|ALKL2_RAT Isoform 1 of ALK and LTK ligand 2  OS=Rattus norvegicus OX=10116 GN=Alkal2 PE=2 SV=1 CANONICAL=B2RZ42-1"
    },
    "isoforms": [
        {
            "isoform_ac": "B2RZ42-1",
            "url": "",
            "sequence": {
                "sequence": "MRVSGRPMLLALLLLLSTVGDPGHAQPRGPADRQTLLRLLVELVQELKKFHIGDSKRLQLLGESDFALGRREATDYGADQEEQRVEIVPRDLRMKDKFLKHLTGPLYFSPKCSKHFHRLYHNTRDCTIPAYYKRCARLLTRLAVSPMCMER",
                "length": 151,
                "header": "sp|B2RZ42-1|ALKL2_RAT Isoform 1 of ALK and LTK ligand 2  OS=Rattus norvegicus OX=10116 GN=Alkal2 PE=2 SV=1 CANONICAL=B2RZ42-1"
            },
            "locus": {
                "chromosome": "6",
                "start_pos": 47501439,
                "end_pos": 47496262,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000006921",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000006921"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000006921",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000006921"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [],
    "publication": [],
    "pathway": [
        {
            "id": "rno:679566",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:679566",
            "resource": "KEGG Pathway"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "Q6UX46-1",
            "protein_name": "ALK and LTK ligand 2",
            "gene_name": "ALKAL2",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MRGPGHPLLLGLLLVLGAAGRGRGGAEPREPADGQALLRLVVELVQELRKHHSAEHKGLQLLGRDCALGRAEAAGLGPSPEQRVEIVPRDLRMKDKFLKHLTGPLYFSPKCSKHFHRLYHNTRDCTIPAYYKRCARLLTRLAVSPVCMEDKQ",
                "length": 152
            },
            "evidence": [
                {
                    "id": "B2RZ42",
                    "url": "https://omabrowser.org/oma/group/B2RZ42/",
                    "database": "OMA"
                }
            ],
            "common_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q80UG6-1",
            "protein_name": "ALK and LTK ligand 2",
            "gene_name": "Alkal2",
            "tax_id": 10090,
            "organism": "Mus musculus",
            "sequence": {
                "sequence": "MRVSGRPMLLALLLLLSTVGDRGRAQSRGPADRQTLLRLLVELVQELKKFHIGDSKRLQLLGESDFALGRREATDYGADQEEQRVEIVPRDLRMKDKFLKHLTGPLYFSPKCSKHFHRLYHNTRDCTIPAYYKRCARLLTRLAVSPMCMER",
                "length": 151
            },
            "evidence": [
                {
                    "id": "B2RZ42",
                    "url": "https://omabrowser.org/oma/group/B2RZ42/",
                    "database": "OMA"
                }
            ],
            "common_name": "Mouse"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Cellular Component",
                "total": 3,
                "go_terms": [
                    {
                        "name": "extracellular region",
                        "id": "GO:0005576",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "B2RZ42",
                                "url": "https://www.uniprot.org/uniprot/B2RZ42"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "extracellular space",
                        "id": "GO:0005615",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "B2RZ42",
                                "url": "https://www.uniprot.org/uniprot/B2RZ42"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "plasma membrane",
                        "id": "GO:0005886",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "B2RZ42",
                                "url": "https://www.uniprot.org/uniprot/B2RZ42"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Biological Process",
                "total": 4,
                "go_terms": [
                    {
                        "name": "transmembrane receptor protein tyrosine kinase signaling pathway",
                        "id": "GO:0007169",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007169",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "B2RZ42",
                                "url": "https://www.uniprot.org/uniprot/B2RZ42"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "positive regulation of neuron projection development",
                        "id": "GO:0010976",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010976",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "B2RZ42",
                                "url": "https://www.uniprot.org/uniprot/B2RZ42"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "positive regulation of ERK1 and ERK2 cascade",
                        "id": "GO:0070374",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070374",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "B2RZ42",
                                "url": "https://www.uniprot.org/uniprot/B2RZ42"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "positive regulation of ERK5 cascade",
                        "id": "GO:0070378",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070378",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "B2RZ42",
                                "url": "https://www.uniprot.org/uniprot/B2RZ42"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Molecular Function",
                "total": 4,
                "go_terms": [
                    {
                        "name": "cytokine activity",
                        "id": "GO:0005125",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005125",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "B2RZ42",
                                "url": "https://www.uniprot.org/uniprot/B2RZ42"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "receptor tyrosine kinase binding",
                        "id": "GO:0030971",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030971",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "B2RZ42",
                                "url": "https://www.uniprot.org/uniprot/B2RZ42"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "receptor signaling protein tyrosine kinase activator activity",
                        "id": "GO:0030298",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030298",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "B2RZ42",
                                "url": "https://www.uniprot.org/uniprot/B2RZ42"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "transmembrane receptor protein tyrosine kinase activator activity",
                        "id": "GO:0030297",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030297",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "B2RZ42",
                                "url": "https://www.uniprot.org/uniprot/B2RZ42"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            }
        ]
    },
    "pro_annotation": [],
    "site_annotation": [],
    "ptm_annotation": [],
    "interactions": [],
    "reactions": [],
    "reaction_participants": [],
    "reaction_enzymes": [],
    "biomarkers": [],
    "synthesized_glycans": [],
    "cluster_types": [
        {
            "name": "homologset.oma",
            "label": "OMA Homologs"
        }
    ],
    "section_stats": [
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}
