{ "uniprot_canonical_ac": "B2GV50-1", "uniprot_ac": "B2GV50", "uniprot_id": "RFX2_RAT", "mass": { "chemical_mass": 76537.0, "monoisotopic_mass": 76537.0 }, "refseq": { "ac": "NP_001100347", "name": "DNA-binding protein RFX2 isoform 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100347" }, "gene_names": [ { "name": "Rfx2", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/B2GV50", "id": "B2GV50" }, { "name": "Rfx2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100347", "id": "NP_001100347" } ], "protein_names": [ { "name": "DNA-binding protein RFX2", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "B2GV50" }, { "name": "DNA-binding protein RFX2 isoform 2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100347", "id": "NP_001100347" }, { "name": "DNA-binding protein RFX2; regulatory factor X 2; regulatory factor X, 2 (influences HLA class II expression)", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100347", "id": "NP_001100347" }, { "name": "Regulatory factor X 2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "B2GV50" } ], "function": [ { "annotation": "RFX2 and NF-Y binding to the testis-specific histone H1t promoter may be required for transcriptional activation in primary spermatocytes", "evidence": [ { "database": "RefSeq", "id": "NP_001100347", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100347" }, { "database": "PubMed", "id": "18247329", "url": "https://glygen.org/publication/PubMed/18247329" } ] }, { "annotation": "These data support the hypothesis that RFX2 expression is upregulated in spermatocytes where it participates in activating transcription of the H1t gene and other testis genes.", "evidence": [ { "database": "RefSeq", "id": "NP_001100347", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100347" }, { "database": "PubMed", "id": "16676351", "url": "https://glygen.org/publication/PubMed/16676351" } ] }, { "annotation": "Transcription factor that acts as a key regulator of spermatogenesis (By similarity). Acts by regulating expression of genes required for the haploid phase during spermiogenesis, such as genes required for cilium assembly and function (By similarity). Recognizes and binds the X-box, a regulatory motif with DNA sequence 5'-GTNRCC(0-3N)RGYAAC-3' present on promoters (PubMed:14743396, PubMed:15526285, PubMed:16676351, PubMed:18247329). Probably activates transcription of the testis-specific histone gene H1-6 (PubMed:14743396, PubMed:15526285, PubMed:16676351, PubMed:18247329).", "evidence": [ { "database": "UniProtKB", "id": "B2GV50", "url": "https://www.uniprot.org/uniprot/B2GV50#function" }, { "database": "PubMed", "id": "16676351", "url": "https://glygen.org/publication/PubMed/16676351" }, { "database": "PubMed", "id": "14743396", "url": "https://glygen.org/publication/PubMed/14743396" }, { "database": "PubMed", "id": "15526285", "url": "https://glygen.org/publication/PubMed/15526285" }, { "database": "PubMed", "id": "18247329", "url": "https://glygen.org/publication/PubMed/18247329" }, { "database": "UniProtKB", "id": "P48379", "url": "https://www.uniprot.org/uniprot/P48379#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "B2GV50", "url": "https://www.uniprot.org/uniprot/B2GV50" } ], "common_name": "Rat" } ], "gene": [ { "name": "Rfx2", "url": "https://www.uniprot.org/uniprot/B2GV50", "locus": { "chromosome": "9", "start_pos": 1604646, "end_pos": 1671027, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000045846", "url": "https://www.ensembl.org/id/ENSRNOG00000045846" } ] } } ], "crossref": [ { "id": "ENSRNOG00000045846", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000045846", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "301121", "url": "https://www.ncbi.nlm.nih.gov/gene/301121", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003150", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003150", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007668", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007668", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036388", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036388", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036390", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036390", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039779", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039779", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "rno:301121", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:301121", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "QFIDMSH", "url": "https://omabrowser.org/oma/group/QFIDMSH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "2915941at2759", "url": "http://www.orthodb.org/?query=2915941at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12619", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12619", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12619:SF17", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12619:SF17", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02257", "url": "http://pfam.xfam.org/family/PF02257", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF04589", "url": "http://pfam.xfam.org/family/PF04589", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_B2GV50", "url": "http://purl.obolibrary.org/obo/PR_B2GV50", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_001100347", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100347", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "1588579", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1588579", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "A0A0G2K7V5", "url": "https://www.uniprot.org/uniprot/A0A0G2K7V5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0G2K7V5-1", "url": "https://www.uniprot.org/uniprot/A0A0G2K7V5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "B2GV50", "url": "https://www.uniprot.org/uniprot/B2GV50", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "B2GV50-1", "url": "https://www.uniprot.org/uniprot/B2GV50-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MQNSEGGADSPATVALRPAAQPVPASPQRVLVQAAGSTPKGTPMQTLTLPRVQPVPPQVQHVYPAQVQYVEGGDAVYANGAIRAAYTYNPDPQLYAPSSAASYFETPGGAQVTVAASSPPAVPSHGMVGITMDVSGTPIVSGAGTYLIHGGMDSTRHSLAHTARSSPATLQWLLDNYETAEGVSLPRSSLYNHYLRHCQEHKLEPVNAASFGKLIRSVFMGLRTRRLGTRGNSKYHYYGIRLKPDSPLNRLQEDTQYMAMRQQPTHQKPRYRPAQKSDSLGDGSAHSNMHSTPEQAMAAQGQHHQQYIDVSHVFPEFPAPDLGSTLLQESVTLHDVKALQLVYRRHCEATLDVVMNLQFQYIEKLWLSFWNCKATSSDGRASLPASDEEPEVTLLPKDKLISLCKCEPILQWMRSCDHILYQALVETLIPDVLRPVPSSLTQAIRNFAKSLEGWLINAMSGFPQQVIQTKVGVVSAFAQTLRRYTSLNHLAQAARAVLQNTSQINQMLSDLNRVDFANVQEQASWVCQCEESLVQRLEHDFKVTLQQQSSLDQWASWLDNVVTQVLKQHAGSPSFPKAARQFLLKWSFYSSMVIRDLTLRSAASFGSFHLIRLLYDEYMFYLVEHRVAQATGETPIAVMGEFNDLASLSLTLLDKEDIGDGHSSEADVDGRSLGEPLVKRERSDPSHPLQGI", "length": 692, "header": "sp|B2GV50-1|RFX2_RAT Isoform 1 of DNA-binding protein RFX2 OS=Rattus norvegicus OX=10116 GN=Rfx2 PE=1 SV=1 CANONICAL=B2GV50-1" }, "isoforms": [ { "isoform_ac": "A0A0G2K7V5-1", "url": "", "sequence": { "sequence": "MQNSEGGADSPATVALRPAAQPVPASPQRVLVQAAGSTPKGTPMQTLTLPRVQPVPPQVQHVYPAQVQYVEGGDAVYANGAIRAAYTYNPDPQLYAPSSAASYFETPGGAQVTVAASSPPAVPSHGMVGITMDVSGTPIVSGAGTYLIHGGMDSTRHSLAHTARSSPATLEMAIETLQKSEGLAPHKGGLLNSHLQWLLDNYETAEGVSLPRSSLYNHYLRHCQEHKLEPVNAASFGKLIRSVFMGLRTRRLGTRGNSKYHYYGIRLKPDSPLNRLQEDTQYMAMRQQPTHQKPRYRPAQKSDSLGDGSAHSNMHSTPEQAMAAQGQHHQQYIDVSHVFPEFPAPDLGSTLLQESVTLHDVKALQLVYRRHCEATLDVVMNLQFQYIEKLWLSFWNCKATSSDGRASLPASDEEPEVTLLPKDKLISLCKCEPILQWMRSCDHILYQALVETLIPDVLRPVPSSLTQAIRNFAKSLEGWLINAMSGFPQQVIQTKVGVVSAFAQTLRRYTSLNHLAQAARAVLQNTSQINQMLSDLNRVDFANVQEQASWVCQCEESLVQRLEHDFKVTLQQQSSLDQWASWLDNVVTQVLKQHAGSPSFPKAARQFLLKWSFYSSMVIRDLTLRSAASFGSFHLIRLLYDEYMFYLVEHRVAQATGETPIAVMGEFNDLASLSLTLLDKEDIGDGHSSEADVDGRSLGEPLVKRERSDPSHPLQGI", "length": 717, "header": "tr|A0A0G2K7V5-1|RFX2_RAT Computationally mapped isoform of DNA-binding protein RFX2 OS=Rattus norvegicus OX=10116 GN=Rfx2 PE=1 SV=1 CANONICAL=B2GV50-1" }, "locus": { "chromosome": "9", "start_pos": 1639127, "end_pos": 1605713, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000084312.2", "url": "https://www.ensembl.org/id/ENSRNOT00000084312.2" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000074363.1", "url": "https://www.ensembl.org/id/ENSRNOP00000074363.1" } ] } }, { "isoform_ac": "B2GV50-1", "url": "", "sequence": { "sequence": "MQNSEGGADSPATVALRPAAQPVPASPQRVLVQAAGSTPKGTPMQTLTLPRVQPVPPQVQHVYPAQVQYVEGGDAVYANGAIRAAYTYNPDPQLYAPSSAASYFETPGGAQVTVAASSPPAVPSHGMVGITMDVSGTPIVSGAGTYLIHGGMDSTRHSLAHTARSSPATLQWLLDNYETAEGVSLPRSSLYNHYLRHCQEHKLEPVNAASFGKLIRSVFMGLRTRRLGTRGNSKYHYYGIRLKPDSPLNRLQEDTQYMAMRQQPTHQKPRYRPAQKSDSLGDGSAHSNMHSTPEQAMAAQGQHHQQYIDVSHVFPEFPAPDLGSTLLQESVTLHDVKALQLVYRRHCEATLDVVMNLQFQYIEKLWLSFWNCKATSSDGRASLPASDEEPEVTLLPKDKLISLCKCEPILQWMRSCDHILYQALVETLIPDVLRPVPSSLTQAIRNFAKSLEGWLINAMSGFPQQVIQTKVGVVSAFAQTLRRYTSLNHLAQAARAVLQNTSQINQMLSDLNRVDFANVQEQASWVCQCEESLVQRLEHDFKVTLQQQSSLDQWASWLDNVVTQVLKQHAGSPSFPKAARQFLLKWSFYSSMVIRDLTLRSAASFGSFHLIRLLYDEYMFYLVEHRVAQATGETPIAVMGEFNDLASLSLTLLDKEDIGDGHSSEADVDGRSLGEPLVKRERSDPSHPLQGI", "length": 692, "header": "sp|B2GV50-1|RFX2_RAT Isoform 1 of DNA-binding protein RFX2 OS=Rattus norvegicus OX=10116 GN=Rfx2 PE=1 SV=1 CANONICAL=B2GV50-1" }, "locus": { "chromosome": "9", "start_pos": 1639127, "end_pos": 1605713, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000073025", "url": "https://www.ensembl.org/id/ENSRNOT00000073025" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000064610", "url": "https://www.ensembl.org/id/ENSRNOP00000064610" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 26, "end_pos": 26, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "B2GV50", "url": "https://www.uniprot.org/uniprot/B2GV50" } ], "site_lbl": "Ser26" }, { "start_pos": 386, "end_pos": 386, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "B2GV50", "url": "https://www.uniprot.org/uniprot/B2GV50" }, { "database": "PubMed", "id": "22673903", "url": "https://glygen.org/publication/PubMed/22673903" }, { "database": "iPTMnet", "id": "B2GV50", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/B2GV50" } ], "site_lbl": "Ser386" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Regulatory factor X2 (RFX2) binds to the H1t/TE1 promoter element and activates transcription of the testis-specific histone H1t gene.", "journal": "J. Cell. Biochem.", "date": "2004", "authors": "Grimes S.R., Wolfe S.A., Wilkerson D.C., Prado S.", "evidence": [ { "database": "UniProtKB", "id": "B2GV50", "url": "https://www.uniprot.org/uniprot/B2GV50" } ], "reference": [ { "type": "PubMed", "id": "14743396", "url": "https://glygen.org/publication/PubMed/14743396" } ] }, { "title": "RFX2 is a potential transcriptional regulatory factor for histone H1t and other genes expressed during the meiotic phase of spermatogenesis.", "journal": "Biol. Reprod.", "date": "2004", "authors": "Horvath G.C., Kistler M.K., Kistler W.S.", "evidence": [ { "database": "UniProtKB", "id": "B2GV50", "url": "https://www.uniprot.org/uniprot/B2GV50" } ], "reference": [ { "type": "PubMed", "id": "15229132", "url": "https://glygen.org/publication/PubMed/15229132" } ] }, { "title": "Transcriptional activation of the testis-specific histone H1t gene by RFX2 may require both proximal promoter X-box elements.", "journal": "J. Cell. Biochem.", "date": "2005", "authors": "Grimes S.R., Wolfe S.A., Prado S.", "evidence": [ { "database": "UniProtKB", "id": "B2GV50", "url": "https://www.uniprot.org/uniprot/B2GV50" } ], "reference": [ { "type": "PubMed", "id": "15526285", "url": "https://glygen.org/publication/PubMed/15526285" } ] }, { "title": "Transcription factor RFX2 is abundant in rat testis and enriched in nuclei of primary spermatocytes where it appears to be required for transcription of the testis-specific histone H1t gene.", "journal": "J. Cell. Biochem.", "date": "2006", "authors": "Wolfe SA, van Wert J, Grimes SR", "evidence": [ { "database": "UniProtKB", "id": "B2GV50", "url": "https://www.uniprot.org/uniprot/B2GV50" }, { "database": "RefSeq", "id": "NP_001100347", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100347" } ], "reference": [ { "type": "PubMed", "id": "16676351", "url": "https://glygen.org/publication/PubMed/16676351" } ] }, { "title": "Binding of RFX2 and NF-Y to the testis-specific histone H1t promoter may be required for transcriptional activation in primary spermatocytes.", "journal": "J. Cell. Biochem.", "date": "2008", "authors": "VanWert JM, Wolfe SA, Grimes SR", "evidence": [ { "database": "UniProtKB", "id": "B2GV50", "url": "https://www.uniprot.org/uniprot/B2GV50" }, { "database": "RefSeq", "id": "NP_001100347", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100347" } ], "reference": [ { "type": "PubMed", "id": "18247329", "url": "https://glygen.org/publication/PubMed/18247329" } ] }, { "title": "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.", "journal": "Nature communications", "date": "2012", "authors": "Lundby A, Secher A, Lage K, Nordsborg NB, Dmytriyev A, Lundby C, Olsen JV", "evidence": [ { "database": "UniProtKB", "id": "B2GV50", "url": "https://www.uniprot.org/uniprot/B2GV50" }, { "database": "UniProtKB", "id": "A0A0G2K7V5", "url": "https://www.uniprot.org/uniprot/A0A0G2K7V5" }, { "database": "iPTMnet", "id": "B2GV50", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/B2GV50" } ], "reference": [ { "type": "PubMed", "id": "22673903", "url": "https://glygen.org/publication/PubMed/22673903" } ] } ], "pathway": [ { "id": "rno:301121", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:301121", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "P48378-1", "protein_name": "DNA-binding protein RFX2", "gene_name": "RFX2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MQNSEGGADSPASVALRPSAAAPPVPASPQRVLVQAASSNPKGAQMQPISLPRVQQVPQQVQPVQHVYPAQVQYVEGGDAVYTNGAIRTAYTYNPEPQMYAPSSTASYFEAPGGAQVTVAASSPPAVPSHSMVGITMDVGGSPIVSSAGAYLIHGGMDSTRHSLAHTSRSSPATLEMAIENLQKSEGITSHKSGLLNSHLQWLLDNYETAEGVSLPRSSLYNHYLRHCQEHKLDPVNAASFGKLIRSVFMGLRTRRLGTRGNSKYHYYGIRLKPDSPLNRLQEDTQYMAMRQQPMHQKPRYRPAQKTDSLGDSGSHSGLHSTPEQTMAVQSQHHQQYIDVSHVFPEFPAPDLGSFLLQDGVTLHDVKALQLVYRRHCEATVDVVMNLQFHYIEKLWLSFWNSKASSSDGPTSLPASDEDPEGAVLPKDKLISLCQCDPILRWMRSCDHILYQALVEILIPDVLRPVPSTLTQAIRNFAKSLEGWLTNAMSDFPQQVIQTKVGVVSAFAQTLRRYTSLNHLAQAARAVLQNTSQINQMLSDLNRVDFANVQEQASWVCQCEESVVQRLEQDFKLTLQQQSSLDQWASWLDSVVTQVLKQHAGSPSFPKAARQFLLKWSFYSSMVIRDLTLRSAASFGSFHLIRLLYDEYMFYLVEHRVAEATGETPIAVMGEFNDLASLSLTLLDKDDMGDEQRGSEAGPDARSLGEPLVKRERSDPNHSLQGI", "length": 723 }, "evidence": [ { "id": "45233423", "url": "http://www.informatics.jax.org/homology/45233423", "database": "MGI" } ], "common_name": "Human" }, { "uniprot_canonical_ac": "P48379-1", "protein_name": "DNA-binding protein RFX2", "gene_name": "Rfx2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MQNSEGGADSPASVALRPAAQPMPASPQRVLVQAAGSTPKGTPMQTLTLPRVQPVPPQVQHVYPAQVQYVEGGDAVYANGAIRAAYAYNPDPQLYAPSSAASYFETPGGTQVTVAASSPPAVPSHGMVGITMDVSGTPIVSGAGAYLIHGGMDGTRHSLAHTARSSPATLEMAIETLQKSEGLAPHKGGLLNSHLQWLLDNYETAEGVSLPRSSLYNHYLRHCQEHKLEPVNAASFGKLIRSVFMGLRTRRLGTRGNSKYHYYGIRLKPDSPLNRLQEDTQYMAMRQQPTHQKPRYRPAQKSDSLGDGSAHSNMHGMPDQAMATQGQHHQQYIDVSHVFPEFPAPDLGSTLLQESVTLHDVKALQLVYRRHCEATLDVVMNLQFQYIEKLWLSFWNCKATSSDSCASLPASDEDPEVTLLPKEKLISLCKCEPILQWMRSCDHILYQTLVETLIPDVLRPVPSSLTQAIRNFAKSLEGWLINAMSGFPQQVIQTKVGVVSAFAQTLRRYTSLNHLAQAARAVLQNTSQINQMLSDLNRVDFANVQEQASWVCQCEESLVQRLEHDFKVTLQQQSSLDQWASWLDNVVTQVLKQHSGSPSFPKAARQFLLKWSFYSSMVIRDLTLRSAASFGSFHLIRLLYDEYMFYLVEHRVAQATGETPIAVMGEFNDLASLSLTLLDKEDIGDGHSSEADVDGRSLGEPLVKRERSDPSHPLQGI", "length": 717 }, "evidence": [ { "id": "45233423", "url": "http://www.informatics.jax.org/homology/45233423", "database": "MGI" } ], "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 6, "go_terms": [ { "name": "DNA-binding transcription factor activity", "id": "GO:0003700", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003700", "evidence": [ { "database": "UniProtKB", "id": "B2GV50", "url": "https://www.uniprot.org/uniprot/B2GV50" } ], "pmid": "" }, { "name": "RNA polymerase II transcription regulatory region sequence-specific DNA binding", "id": "GO:0000977", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000977", "evidence": [ { "database": "UniProtKB", "id": "B2GV50", "url": "https://www.uniprot.org/uniprot/B2GV50" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "B2GV50", "url": "https://www.uniprot.org/uniprot/B2GV50" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "B2GV50", "url": "https://www.uniprot.org/uniprot/B2GV50" } ], "pmid": "" }, { "name": "DNA-binding transcription activator activity, RNA polymerase II-specific", "id": "GO:0001228", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001228", "evidence": [ { "database": "UniProtKB", "id": "B2GV50", "url": "https://www.uniprot.org/uniprot/B2GV50" } ], "pmid": "" }, { "name": "sequence-specific double-stranded DNA binding", "id": "GO:1990837", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990837", "evidence": [ { "database": "UniProtKB", "id": "B2GV50", "url": "https://www.uniprot.org/uniprot/B2GV50" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "B2GV50", "url": "https://www.uniprot.org/uniprot/B2GV50" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "B2GV50", "url": "https://www.uniprot.org/uniprot/B2GV50" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "B2GV50", "url": "https://www.uniprot.org/uniprot/B2GV50" } ], "pmid": "" }, { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "B2GV50", "url": "https://www.uniprot.org/uniprot/B2GV50" } ], "pmid": "" }, { "name": "spermatid development", "id": "GO:0007286", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007286", "evidence": [ { "database": "UniProtKB", "id": "B2GV50", "url": "https://www.uniprot.org/uniprot/B2GV50" } ], "pmid": "" }, { "name": "cellular response to leukemia inhibitory factor", "id": "GO:1990830", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990830", "evidence": [ { "database": "UniProtKB", "id": "B2GV50", "url": "https://www.uniprot.org/uniprot/B2GV50" } ], "pmid": "" }, { "name": "cilium assembly", "id": "GO:0060271", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060271", "evidence": [ { "database": "UniProtKB", "id": "B2GV50", "url": "https://www.uniprot.org/uniprot/B2GV50" } ], "pmid": "" }, { "name": "acrosome assembly", "id": "GO:0001675", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001675", "evidence": [ { "database": "UniProtKB", "id": "B2GV50", "url": "https://www.uniprot.org/uniprot/B2GV50" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 500, "end_pos": 502, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 6 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }