{ "uniprot_canonical_ac": "B1B212-1", "uniprot_ac": "B1B212", "uniprot_id": "H60B_MOUSE", "mass": { "chemical_mass": 28224.0, "monoisotopic_mass": 28224.0 }, "refseq": { "ac": "NP_001171246", "name": "histocompatibility antigen 60b precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001171246" }, "gene_names": [ { "name": "H60b", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/B1B212", "id": "B1B212" }, { "name": "EG667281", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001171246", "id": "NP_001171246" }, { "name": "H60b", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001171246", "id": "NP_001171246" } ], "protein_names": [ { "name": "Histocompatibility antigen 60b", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "B1B212" }, { "name": "histocompatibility antigen 60b precursor", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001171246", "id": "NP_001171246" }, { "name": "histocompatibility antigen 60b", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001171246", "id": "NP_001171246" } ], "function": [ { "annotation": "Identified two novel mouse chromosome 10-encoded NKG2D ligands, H60b and H60c, structurally resembling H60.", "evidence": [ { "database": "RefSeq", "id": "NP_001171246", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001171246" }, { "database": "PubMed", "id": "18209064", "url": "https://glygen.org/publication/PubMed/18209064" } ] }, { "annotation": "Ligand for the KLRK1 immunosurveillance receptor. Binding to KLRK1 stimulates cell lysis in vitro.", "evidence": [ { "database": "UniProtKB", "id": "B1B212", "url": "https://www.uniprot.org/uniprot/B1B212#function" }, { "database": "PubMed", "id": "18209064", "url": "https://glygen.org/publication/PubMed/18209064" } ] } ], "disease": [], "snv": [ { "evidence": [ { "id": "rs51480196", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs51480196" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 167, "end_pos": 167, "sequence_org": "L", "sequence_mut": "S", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NKL->NKS).", "chr_id": "10", "chr_pos": "22162276", "ref_nt": "C", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "L167", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1133314405", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1133314405" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 91, "end_pos": 91, "sequence_org": "A", "sequence_mut": "T", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NDA->NDT).", "chr_id": "10", "chr_pos": "22162047", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "A91", "keywords": [ "ebi", "germline" ] } ], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "B1B212", "url": "https://www.uniprot.org/uniprot/B1B212" } ], "common_name": "Mouse" } ], "gene": [ { "name": "H60b", "url": "https://www.uniprot.org/uniprot/B1B212", "locus": { "chromosome": "10", "start_pos": 22164748, "end_pos": 22034485, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000075297", "url": "https://www.ensembl.org/id/ENSMUSG00000075297" } ] } } ], "crossref": [ { "id": "ENSMUSG00000075297", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000075297", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "667281", "url": "https://www.ncbi.nlm.nih.gov/gene/667281", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR011162", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011162", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037055", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037055", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "mmu:667281", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:667281", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "3649078", "url": "http://www.informatics.jax.org/marker/MGI:3649078", "database": "MGI", "categories": [ "Organism-specific" ] }, { "id": "LTWRESH", "url": "https://omabrowser.org/oma/group/LTWRESH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "4848595at2759", "url": "http://www.orthodb.org/?query=4848595at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PR_B1B212", "url": "http://purl.obolibrary.org/obo/PR_B1B212", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_001171246", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001171246", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "B1B212", "url": "https://www.uniprot.org/uniprot/B1B212", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "B1B212-1", "url": "https://www.uniprot.org/uniprot/B1B212-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAKSSLSLNWSLLVLLNFLGATLSTGTDSLSCELTFNHRTLHGQCSVNGKTLLDFGDKKHEGNATEMCADLSQSLRELSEGMRNQQSGNDALNVTTQSQYNQGEFIGGFWAINTDEQHSIYFYPLNMTWRESHSDNSSAMEHWKNKNLEKDIRNVLIIYFSRCLNKLSPHFREMPKSKIKVLDTTQNTNTTQIHPTVNNSQHNSDTQGLSFTWIVIICIGGIVSFMAFMVFAWCMLKKKKGALCCSSSSTT", "length": 251, "header": "sp|B1B212-1|H60B_MOUSE Isoform 1 of Histocompatibility antigen 60b OS=Mus musculus OX=10090 GN=H60b PE=2 SV=1 CANONICAL=B1B212-1" }, "isoforms": [ { "isoform_ac": "B1B212-1", "url": "", "sequence": { "sequence": "MAKSSLSLNWSLLVLLNFLGATLSTGTDSLSCELTFNHRTLHGQCSVNGKTLLDFGDKKHEGNATEMCADLSQSLRELSEGMRNQQSGNDALNVTTQSQYNQGEFIGGFWAINTDEQHSIYFYPLNMTWRESHSDNSSAMEHWKNKNLEKDIRNVLIIYFSRCLNKLSPHFREMPKSKIKVLDTTQNTNTTQIHPTVNNSQHNSDTQGLSFTWIVIICIGGIVSFMAFMVFAWCMLKKKKGALCCSSSSTT", "length": 251, "header": "sp|B1B212-1|H60B_MOUSE Isoform 1 of Histocompatibility antigen 60b OS=Mus musculus OX=10090 GN=H60b PE=2 SV=1 CANONICAL=B1B212-1" }, "locus": { "chromosome": "10", "start_pos": 22164645, "end_pos": 22159387, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000105522", "url": "https://www.ensembl.org/id/ENSMUST00000105522" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000101161", "url": "https://www.ensembl.org/id/ENSMUSP00000101161" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 126, "start_aa": "Asn", "end_pos": 126, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn126", "evidence": [ { "id": "B1B212", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B1B212#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 189, "start_aa": "Asn", "end_pos": 189, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn189", "evidence": [ { "id": "B1B212", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B1B212#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 63, "start_aa": "Asn", "end_pos": 63, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn63", "evidence": [ { "id": "B1B212", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B1B212#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 93, "start_aa": "Asn", "end_pos": 93, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn93", "evidence": [ { "id": "B1B212", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B1B212#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Two novel NKG2D ligands of the mouse H60 family with differential expression patterns and binding affinities to NKG2D.", "journal": "J. Immunol.", "date": "2008", "authors": "Takada A, Yoshida S, Kajikawa M, Miyatake Y, Tomaru U, Sakai M, Chiba H, Maenaka K, Kohda D, Fugo K, Kasahara M", "evidence": [ { "database": "UniProtKB", "id": "B1B212", "url": "https://www.uniprot.org/uniprot/B1B212" }, { "database": "RefSeq", "id": "NP_001171246", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001171246" } ], "reference": [ { "type": "PubMed", "id": "18209064", "url": "https://glygen.org/publication/PubMed/18209064" } ] } ], "pathway": [ { "id": "mmu:667281", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:667281", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "antigen processing and presentation of endogenous peptide antigen via MHC class Ib", "id": "GO:0002476", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002476", "evidence": [ { "database": "UniProtKB", "id": "B1B212", "url": "https://www.uniprot.org/uniprot/B1B212" } ], "pmid": "" }, { "name": "immune response", "id": "GO:0006955", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006955", "evidence": [ { "database": "UniProtKB", "id": "B1B212", "url": "https://www.uniprot.org/uniprot/B1B212" } ], "pmid": "" }, { "name": "antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent", "id": "GO:0002486", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002486", "evidence": [ { "database": "UniProtKB", "id": "B1B212", "url": "https://www.uniprot.org/uniprot/B1B212" } ], "pmid": "" }, { "name": "positive regulation of T cell mediated cytotoxicity", "id": "GO:0001916", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001916", "evidence": [ { "database": "UniProtKB", "id": "B1B212", "url": "https://www.uniprot.org/uniprot/B1B212" } ], "pmid": "" }, { "name": "natural killer cell mediated cytotoxicity", "id": "GO:0042267", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042267", "evidence": [ { "database": "UniProtKB", "id": "B1B212", "url": "https://www.uniprot.org/uniprot/B1B212" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "natural killer cell lectin-like receptor binding", "id": "GO:0046703", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046703", "evidence": [ { "database": "UniProtKB", "id": "B1B212", "url": "https://www.uniprot.org/uniprot/B1B212" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "B1B212", "url": "https://www.uniprot.org/uniprot/B1B212" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "B1B212", "url": "https://www.uniprot.org/uniprot/B1B212" } ], "pmid": "" }, { "name": "external side of plasma membrane", "id": "GO:0009897", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009897", "evidence": [ { "database": "UniProtKB", "id": "B1B212", "url": "https://www.uniprot.org/uniprot/B1B212" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 126, "end_pos": 128, "annotation": "n_glycosylation_sequon" }, { "start_pos": 136, "end_pos": 138, "annotation": "n_glycosylation_sequon" }, { "start_pos": 189, "end_pos": 191, "annotation": "n_glycosylation_sequon" }, { "start_pos": 198, "end_pos": 200, "annotation": "n_glycosylation_sequon" }, { "start_pos": 63, "end_pos": 65, "annotation": "n_glycosylation_sequon" }, { "start_pos": 93, "end_pos": 95, "annotation": "n_glycosylation_sequon" }, { "start_pos": 9, "end_pos": 11, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], 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