{ "uniprot_canonical_ac": "B1AWN4-1", "uniprot_ac": "B1AWN4", "uniprot_id": "AT10B_MOUSE", "mass": { "chemical_mass": 166437.0, "monoisotopic_mass": 166437.0 }, "refseq": { "ac": "XP_006533597", "name": "phospholipid-transporting ATPase VB isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006533597" }, "gene_names": [ { "name": "Atp10b", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/B1AWN4", "id": "B1AWN4" }, { "name": "5930426O13Rik; 9030605H24Rik", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006533597", "id": "XP_006533597" }, { "name": "Atp10b", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006533597", "id": "XP_006533597" } ], "protein_names": [ { "name": "Phospholipid-transporting ATPase VB", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "B1AWN4" }, { "name": "7.6.2.1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "B1AWN4" }, { "name": "phospholipid-transporting ATPase VB isoform X2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006533597", "id": "XP_006533597" }, { "name": "phospholipid-transporting ATPase VB", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_795973", "id": "NP_795973" }, { "name": "potential phospholipid-transporting ATPase VB; probable phospholipid-transporting ATPase VB", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_795973", "id": "NP_795973" } ], "function": [ { "annotation": "Catalytic component of a P4-ATPase flippase complex, which catalyzes the hydrolysis of ATP coupled to the transport of glucosylceramide (GlcCer) from the outer to the inner leaflet of lysosome membranes (By similarity). Plays an important role in the maintenance of lysosome membrane integrity and function in cortical neurons (PubMed:32172343).", "evidence": [ { "database": "UniProtKB", "id": "B1AWN4", "url": "https://www.uniprot.org/uniprot/B1AWN4#function" }, { "database": "PubMed", "id": "32172343", "url": "https://glygen.org/publication/PubMed/32172343" }, { "database": "UniProtKB", "id": "O94823", "url": "https://www.uniprot.org/uniprot/O94823#function" } ] } ], "disease": [ { "disease_id": "DOID:0070221", "recommended_name": { "id": "DOID:0070221", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0070221", "name": "progressive familial intrahepatic cholestasis", "description": "An intrahepatic cholestasis characterized by early onset of chronic unremitting cholestasis of hepatocellular origin that progresses to hepatic fibrosis, cirrhosis, and end-stage liver disease before adulthood." }, "synonyms": [ { "id": "DOID:0070221", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0070221", "name": "PFIC; Byler disease", "description": "" }, { "id": "MONDO:0008892", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008892", "name": "progressive familial intrahepatic cholestasis type 1", "description": "PFIC1, a type of progressive familial intrahepathic cholestasis (PFIC), is an infantile hereditary disorder in bile formation that is hepatocellular in origin and associated with extrahepatic features." }, { "id": "MONDO:0008892", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008892", "name": "Byler disease", "description": "" }, { "id": "MONDO:0008892", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008892", "name": "FIC1 deficiency", "description": "" }, { "id": "MONDO:0008892", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008892", "name": "PFIC1", "description": "" }, { "id": "MONDO:0008892", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008892", "name": "cholestasis, progressive familial intrahepatic 1", "description": "" }, { "id": "MONDO:0008892", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008892", "name": "cholestasis, progressive familial intrahepatic, type 1", "description": "" }, { "id": "MONDO:0008892", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008892", "name": "Byler's disease", "description": "" }, { "id": "MONDO:0008892", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008892", "name": "cholestasis, fatal intrahepatic", "description": "" }, { "id": "MONDO:0008892", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008892", "name": "cholestasis, progressive familial intrahepatic, 1", "description": "" }, { "id": "MONDO:0008892", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008892", "name": "progressive familial intrahepatic cholestasis", "description": "" }, { "id": "MONDO:0008892", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008892", "name": "severe ATP8B1 deficiency", "description": "" }, { "id": "MIM:211600", "resource": "MIM", "url": "https://www.omim.org/entry/211600", "name": "Cholestasis, progressive familial intrahepatic, 1", "description": "Cholestasis, progressive familial intrahepatic, 1" } ], "evidence": [ { "id": "0070221", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0070221" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "B1AWN4", "url": "https://www.uniprot.org/uniprot/B1AWN4" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Atp10b", "url": "https://www.uniprot.org/uniprot/B1AWN4", "locus": { "chromosome": "11", "start_pos": 43153112, "end_pos": 43040704, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000055415", "url": "https://www.ensembl.org/id/ENSMUSG00000055415" } ] } } ], "crossref": [ { "id": "ENSMUSG00000055415", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000055415", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd02073", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd02073", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "319767", "url": "https://www.ncbi.nlm.nih.gov/gene/319767", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001757", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001757", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006539", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006539", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008250", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008250", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018303", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018303", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023214", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023214", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023298", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023298", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023299", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023299", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032630", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032630", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032631", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032631", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036412", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036412", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR044492", "url": "https://www.ebi.ac.uk/interpro/entry/IPR044492", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "mmu:319767", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:319767", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "2442688", "url": "http://www.informatics.jax.org/marker/MGI:2442688", "database": "MGI", "categories": [ "Organism-specific" ] }, { "id": "MGSEYCH", "url": "https://omabrowser.org/oma/group/MGSEYCH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "275833at2759", "url": "http://www.orthodb.org/?query=275833at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24092", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24092", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24092:SF79", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24092:SF79", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13246", "url": "http://pfam.xfam.org/family/PF13246", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF16209", "url": "http://pfam.xfam.org/family/PF16209", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF16212", "url": "http://pfam.xfam.org/family/PF16212", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_B1AWN4", "url": "http://purl.obolibrary.org/obo/PR_B1AWN4", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-MMU-936837", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-936837", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_795973", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_795973", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "66036", "url": "https://www.rhea-db.org/rhea/66036", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A571BEJ2", "url": "https://www.uniprot.org/uniprot/A0A571BEJ2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A571BEJ2-1", "url": "https://www.uniprot.org/uniprot/A0A571BEJ2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "B1AWN4", "url": "https://www.uniprot.org/uniprot/B1AWN4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "B1AWN4-1", "url": "https://www.uniprot.org/uniprot/B1AWN4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTCSLDFSWLRWKWRTQDGFSQSPSETTPLLSPETDRQSHNTAEQRVVYPNNSMCHQDWKKVCRRYPGNSICTTKYTLLTFLPQNLFEQFHRWANLYFLFLVILNWMPSMEVFHREITIFPLATVLLIIMVKDGIEDFKRYCFDREMNSASIQIYERKEQRYMLKRWQDVRVGDFVQMQCNEIVPADILLLFSSDPSGVCHLETANLDGETNLKQRRVVKGFSQPEVQFQPEHFHSTIVCEKPNNHLSKFKGYMEHPDQTRTGFGSESLLLRGCTIRNTEVAAGIVIYAGHETKAMLNNSGPRYKRSKIERRINTDIFFCIGLLFLMCLIGAVGHSLWNGTFKEHPPFDVPDADGNFLSLALGGFYMFLTMIILLQVLIPISLYVSIELVKLGQVFLLHNDLDLYDEETDLSIQCRALNITEDLGQIQYIFSDKTGTLTENKMVFRRCTIVGSEYCHQENAKRLEMPKELDSDGEEWTQYQCLSFPPRWAQGSTTMRSQGGAQPLRRCHSARVPIQSHCRQRSVGRWETSQPPVAFSSSIEKDVTPDKNLLSKVRDAALWLETSDTRPAKPSHSTTASIADFFLALTICNSVMVSTTTEPRKRVTTPPANKALGTSLEKIQQLFQRLKLLSLSQSFSSTAPSDTDLGESLGPNLPTIDSDEKDDTSVCSGDCSTDGGYRSSTWEQGDILGSESGTSLEEGLEAPTLSQDEPELCYEAESPDEAALVHAARAYSFTLVSRTPEQVTVRLPQGICLTFDLLFTLGFDSVRKRMSVVVRHPLTDEIIVYTKGADSVIMDLLEDPACESNIDVEKKLKRIRARTQKHLDLYARDGLRTLCIAKKVVDEEDFQRWASFRREAEASLDNREELLMETAQHLENHLTLLGATGIEDRLQEGVPDTIAALREAGIQLWVLTGDKQETAVNIAYSCKLLDQTDTVYSINTENQETCESILNCTLEDIKRFHEPQQPARKLCGHRIPPKMPSVNSGAMAPEIGLVIDGKTLNAIFQGKLENKFLELTQYCRSVLCCRSTPLQKSMIVKLVRDKLSVMTLSIGDGANDVSMIQAADIGIGISGQEGMQAVMSSDFAIARFSHLKKLLLVHGHWCYSRLARMVVYYFYKNVCYVNLLFWYQFFCGFSGSTMIDYWQMIFFNLFFTSLPPIIFGVLDKDVSAETLLALPELYKSGQNSECYNLPTFWVSMADAFYQSLICFFIPYLTYRGSDIDVFTFGTPINTISLTTILLHQAMEMKTWTVLHGLVLLGSFLMYFVVSLIYNATCVTCNSPTNPYWVMERQLSDPTFYLICLLTPVVALLPRYFLLSLQGTYGKSLISKAQKIDKLPIDKRNLEIQNWRSKQRPAPASASASASAPATGTVHTRPPCHPVPPEAQQNFGASTSKSSGPPRQKHVEDRVLQDPRCSREHSRDDTCTVDTLAKLSSGECLLDPNRTVAPTAYSRGQKDVSRHSSKGSHRRSQSSLTI", "length": 1474, "header": "sp|B1AWN4-1|AT10B_MOUSE Isoform 1 of Phospholipid-transporting ATPase VB OS=Mus musculus OX=10090 GN=Atp10b PE=1 SV=1 CANONICAL=B1AWN4-1" }, "isoforms": [ { "isoform_ac": "A0A571BEJ2-1", "url": "", "sequence": { "sequence": "MRKEGRKRRKKKEDKKRVVVSNLPFEGWPYKENPNRHYRGNQVKTSKYTVLSFIPKNLFEQLHRFANLYFVGIVILNFIPVVNAFQPGVSMVPVCAILTVTAIKDAWEDFRRYKSDKVINNRESLVYSRKEQRYMLKRWQDVRVGDFVQMQCNEIVPADILLLFSSDPSGVCHLETANLDGETNLKQRRVVKGFSQPEVQFQPEHFHSTIVCEKPNNHLSKFKGYMEHPDQTRTGFGSESLLLRGCTIRNTEVAAGIVIYAGHETKAMLNNSGPRYKRSKIERRINTDIFFCIGLLFLMCLIGAVGHSLWNGTFKEHPPFDVPDADGNFLSLALGGFYMFLTMIILLQVLIPISLYVSIELVKLGQVFLLHNDLDLYDEETDLSIQCRALNITEDLGQIQYIFSDKTGTLTENKMVFRRCTIVGSEYCHQENAKRLEMPKELDSDGEEWTQYQCLSFPPRWAQGSTTMRSQGGAQPLRRCHSARVPIQSHCRQRSVGRWETSQPPVAFSSSIEKDVTPDKNLLSKVRDAALWLETSDTRPAKPSHSTTASIADFFLALTICNSVMVSTTTEPRKRVTTPPANKALGTSLEKIQQLFQRLKLLSLSQSFSSTAPSDTDLGESLGPNLPTIDSDEKDDTSVCSGDCSTDGGYRSSTWEQGDILGSESGTSLEEGLEAPTLSQDEPELCYEAESPDEAALVHAARAYSFTLVSRTPEQVTVRLPQGICLTFDLLFTLGFDSVRKRMSVVVRHPLTDEIIVYTKGADSVIMDLLEDPACESNIDVEKKLKRIRARTQKHLDLYARDGLRTLCIAKKVVDEEDFQRWASFRREAEASLDNREELLMETAQHLENHLTLLGATGIEDRLQEGVPDTIAALREAGIQLWVLTGDKQETAVNIAYSCKLLDQTDTVYSINTENQETCESILNCTLEDIKRFHEPQQPARKLCGHRIPPKMPSVNSGAMAPEIGLVIDGKTLNAIFQGKLENKFLELTQYCRSVLCCRSTPLQKSMIVKLVRDKLSVMTLSIGDGANDVSMIQAADIGIGISGQEGMQAVMSSDFAIARFSHLKKLLLVHGHWCYSRLARMVVYYFYKNVCYVNLLFWYQFFCGFSGSTMIDYWQMIFFNLFFTSLPPIIFGVLDKDVSAETLLALPELYKSGQNSECYNLPTFWVSMADAFYQSLICFFIPYLTYRGSDIDVFTFGTPINTISLTTILLHQAMEMKTWTVLHGLVLLGSFLMYFVVSLIYNATCVTCNSPTNPYWVMERQLSDPTFYLICLLTPVVALLPRYFLLSLQGTYGKSLISKAQKIDKLPIDKRNLEIQNWRSKQRPAPASASASASAPATGTVHTRPPCHPVPPEAQQNFGASTSKSSGPPRQKHVEDRVLQDPRCSREHSRDDTCTVDTLAKLSSGECLLDPNRTVAPTAYSRGQKDVSRHSSKGSHRRSQSSLTI", "length": 1446, "header": "tr|A0A571BEJ2-1|AT10B_MOUSE Computationally mapped isoform of Phospholipid-transporting ATPase VB OS=Mus musculus OX=10090 GN=Atp10b PE=1 SV=1 CANONICAL=B1AWN4-1" }, "locus": { "chromosome": "11", "start_pos": 43150725, "end_pos": 43046722, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000238415.2", "url": "https://www.ensembl.org/id/ENSMUST00000238415.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000158770.2", "url": "https://www.ensembl.org/id/ENSMUSP00000158770.2" } ] } }, { "isoform_ac": "B1AWN4-1", "url": "", "sequence": { "sequence": "MTCSLDFSWLRWKWRTQDGFSQSPSETTPLLSPETDRQSHNTAEQRVVYPNNSMCHQDWKKVCRRYPGNSICTTKYTLLTFLPQNLFEQFHRWANLYFLFLVILNWMPSMEVFHREITIFPLATVLLIIMVKDGIEDFKRYCFDREMNSASIQIYERKEQRYMLKRWQDVRVGDFVQMQCNEIVPADILLLFSSDPSGVCHLETANLDGETNLKQRRVVKGFSQPEVQFQPEHFHSTIVCEKPNNHLSKFKGYMEHPDQTRTGFGSESLLLRGCTIRNTEVAAGIVIYAGHETKAMLNNSGPRYKRSKIERRINTDIFFCIGLLFLMCLIGAVGHSLWNGTFKEHPPFDVPDADGNFLSLALGGFYMFLTMIILLQVLIPISLYVSIELVKLGQVFLLHNDLDLYDEETDLSIQCRALNITEDLGQIQYIFSDKTGTLTENKMVFRRCTIVGSEYCHQENAKRLEMPKELDSDGEEWTQYQCLSFPPRWAQGSTTMRSQGGAQPLRRCHSARVPIQSHCRQRSVGRWETSQPPVAFSSSIEKDVTPDKNLLSKVRDAALWLETSDTRPAKPSHSTTASIADFFLALTICNSVMVSTTTEPRKRVTTPPANKALGTSLEKIQQLFQRLKLLSLSQSFSSTAPSDTDLGESLGPNLPTIDSDEKDDTSVCSGDCSTDGGYRSSTWEQGDILGSESGTSLEEGLEAPTLSQDEPELCYEAESPDEAALVHAARAYSFTLVSRTPEQVTVRLPQGICLTFDLLFTLGFDSVRKRMSVVVRHPLTDEIIVYTKGADSVIMDLLEDPACESNIDVEKKLKRIRARTQKHLDLYARDGLRTLCIAKKVVDEEDFQRWASFRREAEASLDNREELLMETAQHLENHLTLLGATGIEDRLQEGVPDTIAALREAGIQLWVLTGDKQETAVNIAYSCKLLDQTDTVYSINTENQETCESILNCTLEDIKRFHEPQQPARKLCGHRIPPKMPSVNSGAMAPEIGLVIDGKTLNAIFQGKLENKFLELTQYCRSVLCCRSTPLQKSMIVKLVRDKLSVMTLSIGDGANDVSMIQAADIGIGISGQEGMQAVMSSDFAIARFSHLKKLLLVHGHWCYSRLARMVVYYFYKNVCYVNLLFWYQFFCGFSGSTMIDYWQMIFFNLFFTSLPPIIFGVLDKDVSAETLLALPELYKSGQNSECYNLPTFWVSMADAFYQSLICFFIPYLTYRGSDIDVFTFGTPINTISLTTILLHQAMEMKTWTVLHGLVLLGSFLMYFVVSLIYNATCVTCNSPTNPYWVMERQLSDPTFYLICLLTPVVALLPRYFLLSLQGTYGKSLISKAQKIDKLPIDKRNLEIQNWRSKQRPAPASASASASAPATGTVHTRPPCHPVPPEAQQNFGASTSKSSGPPRQKHVEDRVLQDPRCSREHSRDDTCTVDTLAKLSSGECLLDPNRTVAPTAYSRGQKDVSRHSSKGSHRRSQSSLTI", "length": 1474, "header": "sp|B1AWN4-1|AT10B_MOUSE Isoform 1 of Phospholipid-transporting ATPase VB OS=Mus musculus OX=10090 GN=Atp10b PE=1 SV=1 CANONICAL=B1AWN4-1" }, "locus": { "chromosome": "11", "start_pos": 43150725, "end_pos": 43042442, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000077659", "url": "https://www.ensembl.org/id/ENSMUST00000077659" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000076844", "url": "https://www.ensembl.org/id/ENSMUSP00000076844" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Mutated ATP10B increases Parkinson's disease risk by compromising lysosomal glucosylceramide export.", "journal": "Acta Neuropathol.", "date": "2020", "authors": "Martin S, Smolders S, Van den Haute C, Heeman B, van Veen S, Crosiers D, Beletchi I, Verstraeten A, Gossye H, Gelders G, Pals P, Hamouda NN, Engelborghs S, Martin JJ, Eggermont J, De Deyn PP, Cras P, Baekelandt V, Vangheluwe P, Van Broeckhoven C", "evidence": [ { "database": "UniProtKB", "id": "B1AWN4", "url": "https://www.uniprot.org/uniprot/B1AWN4" } ], "reference": [ { "type": "PubMed", "id": "32172343", "url": "https://glygen.org/publication/PubMed/32172343" } ] } ], "pathway": [ { "id": "mmu:319767", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:319767", "resource": "KEGG Pathway" }, { "id": "R-MMU-936837", "name": "Ion transport by P-type ATPases", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-936837", "resource": "Reactome", "description": "Ion transport by P-type ATPases" } ], "orthologs": [ { "uniprot_canonical_ac": "D4A4W5-1", "protein_name": "Phospholipid-transporting ATPase", "gene_name": "Atp10b", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MTFSLDFSWLRWKWRSQNGFSQSPSETTPLLSPETGRQSYNPTEQRVVYPNNSMCHQDWKKVSRRYPGNSICTTKYTLLTFLPQNLFEQFHRWANLYFLFLVILNWMPSMEVFHREITMLPLAIVLLVIMVKDGTEDFKRYCFDREMNSASIQIYERKEQSYMQKRWQDVRVGDFVQMRCNEIVPADILLLFSSDPSGVCHLETANLDGETNLKQRRVVKGFSQQEVQFQPEHFHSTIVCEKPNNHLSKFKGYMEHPDETRTGFGSESLLLRGCTIRNTEVAAGIVIYAGHETKAMLNNSGPRYKRSKIERRINTDIFFCIGLLFLMCLIGAVGHSLWNGTFKEHPPFDVPDADGNFLSPALGGFYMFLTMIILLQVLIPISLYVSIELVKLGQVFLLHNDLDLYDEETDLSIQCRALNITEDLGQIQYIFSDKTGTLTENKMVFRRCTIVGNEYCHQENAKRLEMPKELDSDGEEWTQYQCLSFPPRWTQGPATIRSQGGAQPLRRCHSARVPIQSHSRQRSVGRWETSQPPVAFSSSIEKDVTPDKNLLSKVRDAALWLETLDTRPAKPSHSTTASIADFFLALTICNSVMVSTTTEPRKRVTTPPANKALGTSLEKIQHLFQRLKLLSLSQSFSSTAPSDTDLGESLGPNVPTIDADEKDDASVCSGDCSTDGGYRSSTWEQGDNLGSESGTSLEEGLEAPALSLDGPELCYEAESPDEAALVHAARAYSFTLVSRTPEQVTVRLPQGICLTFDLLFTLGFDSVRKRMSVVVRHPLTGEIVVYTKGADSVIMDLLEDPACGNDIDVEKKLKRIRARTQKHLDLYARDGLRTLCIAKKVVNEEDFQRWASFRREAEASLDNREELLMETAQHLENRLTLLGATGIEDRLQEGVPDTIAALREAGIQLWVLTGDKQETAVNVAHSCKLLDQADTVYSINTENQETCESILNCALEDVKRFHEPQQPARKLCGYCIPSKKPSVNLGAMAPEIGLVIDGKTLNAIFQGKLENKFLELTQYCRSVLCCRSTPLQKSMIVKLVRDKLSVMTLSIGDGANDVSMIQAADIGIGISGQEGMQAVMSSDFAIARFSHLKKLLLVHGHWCYSRLARMVVYYFYKNVCYVNLLFWYQFFCGFSGSTMIDYWQMIFFNLFFTSLPPIVFGILDKDVSAETLLALPELYKSGQNSECYNLPTFWVSMADAFYQSLICFFIPYLTYRGSDIDVFTFGTPINTISLTTILLHQAMEMKTWTVLHGLVLLGSFLMYFVVSLIYNATCVTCNSPTNPYWLMERQLSDPMFYLTCLLTPVVALLPRYFLLSLQGTYGKSLISKAQKIDKLPIDKRNLEIQNWRSKQRPTPASASAAAPATGTVHTQPPCCPVPPEAQQDFGASTSKSSSPPRQKQVEDWVLQGPRCSREHSKDDTCSRDTLAKLSSGECLLDPNRTVAPTAYSRGQKDASRHSSKGSHRRSQSSLTI", "length": 1472 }, "evidence": [ { "id": "45236018", "url": "http://www.informatics.jax.org/homology/45236018", "database": "MGI" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "O94823-1", "protein_name": "Phospholipid-transporting ATPase VB", "gene_name": "ATP10B", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MALSVDSSWHRWQWRVRDGFPHCPSETTPLLSPEKGRQSYNLTQQRVVFPNNSIFHQDWEEVSRRYPGNRTCTTKYTLFTFLPRNLFEQFHRWANLYFLFLVILNWMPSMEVFHREITMLPLAIVLFVIMIKDGMEDFKRHRFDKAINCSNIRIYERKEQTYVQKCWKDVRVGDFIQMKCNEIVPADILLLFSSDPNGICHLETASLDGETNLKQRCVVKGFSQQEVQFEPELFHNTIVCEKPNNHLNKFKGYMEHPDQTRTGFGCESLLLRGCTIRNTEMAVGIVIYAGHETKAMLNNSGPRYKRSKIERRMNIDIFFCIGILILMCLIGAVGHSIWNGTFEEHPPFDVPDANGSFLPSALGGFYMFLTMIILLQVLIPISLYVSIELVKLGQVFFLSNDLDLYDEETDLSIQCRALNIAEDLGQIQYIFSDKTGTLTENKMVFRRCTIMGSEYSHQENAKRLETPKELDSDGEEWTQYQCLSFSARWAQDPATMRSQKGAQPLRRSQSARVPIQGHYRQRSMGHRESSQPPVAFSSSIEKDVTPDKNLLTKVRDAALWLETLSDSRPAKASLSTTSSIADFFLALTICNSVMVSTTTEPRQRVTIKPSSKALGTSLEKIQQLFQKLKLLSLSQSFSSTAPSDTDLGESLGANVATTDSDERDDASVCSGGDSTDDGGYRSSMWDQGDILESGSGTSLEEALEAPATDLARPEFCYEAESPDEAALVHAAHAYSFTLVSRTPEQVTVRLPQGTCLTFSLLCTLGFDSVRKRMSVVVRHPLTGEIVVYTKGADSVIMDLLEDPACVPDINMEKKLRKIRARTQKHLDLYARDGLRTLCIAKKVVSEEDFRRWASFRREAEASLDNRDELLMETAQHLENQLTLLGATGIEDRLQEGVPDTIATLREAGIQLWVLTGDKQETAVNIAHSCRLLNQTDTVYTINTENQETCESILNCALEELKQFRELQKPDRKLFGFRLPSKTPSITSEAVVPEAGLVIDGKTLNAIFQGKLEKKFLELTQYCRSVLCCRSTPLQKSMIVKLVRDKLRVMTLSIGDGANDVSMIQAADIGIGISGQEGMQAVMSSDFAITRFKHLKKLLLVHGHWCYSRLARMVVYYLYKNVCYVNLLFWYQFFCGFSSSTMIDYWQMIFFNLFFTSLPPLVFGVLDKDISAETLLALPELYKSGQNSECYNLSTFWISMVDAFYQSLICFFIPYLAYKGSDIDVFTFGTPINTISLTTILLHQAMEMKTWTIFHGVVLLGSFLMYFLVSLLYNATCVICNSPTNPYWVMEGQLSNPTFYLVCFLTPVVALLPRYFFLSLQGTCGKSLISKAQKIDKLPPDKRNLEIQSWRSRQRPAPVPEVARPTHHPVSSITGQDFSASTPKSSNPPKRKHVEESVLHEQRCGTECMRDDSCSGDSSAQLSSGEHLLGPNRIMAYSRGQTDMCRCSKRSSHRRSQSSLTI", "length": 1461 }, "evidence": [ { "id": "45236018", "url": "http://www.informatics.jax.org/homology/45236018", "database": "MGI" }, { "id": "B1AWN4", "url": "https://omabrowser.org/oma/group/B1AWN4/", "database": "OMA" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 6, "go_terms": [ { "name": "magnesium ion binding", "id": "GO:0000287", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000287", "evidence": [ { "database": "UniProtKB", "id": "B1AWN4", "url": "https://www.uniprot.org/uniprot/B1AWN4" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "B1AWN4", "url": "https://www.uniprot.org/uniprot/B1AWN4" } ], "pmid": "" }, { "name": "ATP hydrolysis activity", "id": "GO:0016887", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016887", "evidence": [ { "database": "UniProtKB", "id": "B1AWN4", "url": "https://www.uniprot.org/uniprot/B1AWN4" } ], "pmid": "" }, { "name": "ATPase-coupled intramembrane lipid transporter activity", "id": "GO:0140326", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140326", "evidence": [ { "database": "UniProtKB", "id": "B1AWN4", "url": "https://www.uniprot.org/uniprot/B1AWN4" } ], "pmid": "" }, { "name": "phosphatidylcholine flippase activity", "id": "GO:0140345", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140345", "evidence": [ { "database": "UniProtKB", "id": "B1AWN4", "url": "https://www.uniprot.org/uniprot/B1AWN4" } ], "pmid": "" }, { "name": "glycosylceramide flippase activity", "id": "GO:0140351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140351", "evidence": [ { "database": "UniProtKB", "id": "B1AWN4", "url": "https://www.uniprot.org/uniprot/B1AWN4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 7, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "B1AWN4", "url": "https://www.uniprot.org/uniprot/B1AWN4" } ], "pmid": "" }, { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "B1AWN4", "url": "https://www.uniprot.org/uniprot/B1AWN4" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "B1AWN4", "url": "https://www.uniprot.org/uniprot/B1AWN4" } ], "pmid": "" }, { "name": "lysosomal membrane", "id": "GO:0005765", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005765", "evidence": [ { "database": "UniProtKB", "id": "B1AWN4", "url": "https://www.uniprot.org/uniprot/B1AWN4" } ], "pmid": "" }, { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "B1AWN4", "url": "https://www.uniprot.org/uniprot/B1AWN4" } ], "pmid": "" }, { "name": "late endosome membrane", "id": "GO:0031902", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031902", "evidence": [ { "database": "UniProtKB", "id": "B1AWN4", "url": "https://www.uniprot.org/uniprot/B1AWN4" } ], "pmid": "" }, { "name": "phospholipid-translocating ATPase complex", "id": "GO:1990531", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990531", "evidence": [ { "database": "UniProtKB", "id": "B1AWN4", "url": "https://www.uniprot.org/uniprot/B1AWN4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "phospholipid transport", "id": "GO:0015914", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015914", "evidence": [ { "database": "UniProtKB", "id": "B1AWN4", "url": "https://www.uniprot.org/uniprot/B1AWN4" } ], "pmid": "" }, { "name": "phospholipid translocation", "id": "GO:0045332", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045332", "evidence": [ { "database": "UniProtKB", "id": "B1AWN4", "url": "https://www.uniprot.org/uniprot/B1AWN4" } ], "pmid": "" }, { "name": "lysosomal membrane organization", "id": "GO:0097212", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097212", "evidence": [ { "database": "UniProtKB", "id": "B1AWN4", "url": "https://www.uniprot.org/uniprot/B1AWN4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1271, "end_pos": 1273, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1441, "end_pos": 1443, "annotation": "n_glycosylation_sequon" }, { "start_pos": 298, "end_pos": 300, "annotation": "n_glycosylation_sequon" }, { "start_pos": 339, "end_pos": 341, "annotation": "n_glycosylation_sequon" }, { "start_pos": 419, "end_pos": 421, "annotation": "n_glycosylation_sequon" }, { "start_pos": 51, "end_pos": 53, "annotation": "n_glycosylation_sequon" }, { "start_pos": 952, "end_pos": 954, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [ { "annotation": "Autophosphorylated at the conserved aspartate of the P-type ATPase signature sequence.", "evidence": [ { "database": "UniProtKB", "id": "B1AWN4", "url": "https://www.uniprot.org/uniprot/B1AWN4" }, { "database": "PubMed", "id": "O94823", "url": "https://glygen.org/publication/PubMed/O94823" } ] } ], "interactions": [], "reactions": [ { "id": "66036", "name": "", "equation": "a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(out) + ATP + H2O = a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(in) + ADP + H(+) + phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q9P241-1", "O60312-1", "O94823-1", "O54827-1", "Q8K2X1-1", "B1AWN4-1", "P32660-1", "Q12675-1" ], "evidence": [ { "id": "66036", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/66036" } ] }, { "id": "R-MMU-939763", "name": "P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O54827-1", "Q6UQ17-1", "P70704-1", "P98200-1", "Q148W0-1", "O70228-1", "P98195-1", "P98197-1", "Q8K2X1-1", "P98199-1", "Q9QZW0-1", "B1AWN4-1", "A2ANX3-1", "Q6DFW5-1" ], "evidence": [ { "id": "R-MMU-939763", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-939763" } ] }, { "id": "R-MMU-947591", "name": "P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O54827-1", "Q6UQ17-1", "P70704-1", "P98200-1", "Q148W0-1", "O70228-1", "P98195-1", "P98197-1", "Q8K2X1-1", "P98199-1", "Q9QZW0-1", "B1AWN4-1", "A2ANX3-1", "Q6DFW5-1" ], "evidence": [ { "id": "R-MMU-947591", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-947591" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A2ANX3", "gene_name": "Atp8b4", "activity": [ { "ec_number": "7.6.2.1", "activity": "ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.", "evidence": [ { "id": "A2ANX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2ANX3" } ] }, { "ec_number": "7.6.2.1", "activity": "", "evidence": [ { "id": "A2ANX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2ANX3" } ] } ] }, { "uniprot_ac": "B1AWN4", "gene_name": "Atp10b", "activity": [ { "ec_number": "7.6.2.1", "activity": "ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.", "evidence": [ { "id": "B1AWN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B1AWN4" } ] }, { "ec_number": "7.6.2.1", "activity": "", "evidence": [ { "id": "B1AWN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B1AWN4" } ] } ] }, { "uniprot_ac": "O54827", "gene_name": "Atp10a", "activity": [ { "ec_number": "7.6.2.1", "activity": "ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.", "evidence": [ { "id": "O54827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54827" } ] }, { "ec_number": "7.6.2.1", "activity": "", "evidence": [ { "id": "O54827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54827" } ] } ] }, { "uniprot_ac": "O60312", "gene_name": "ATP10A", "activity": [ { "ec_number": "7.6.2.1", "activity": "ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.", "evidence": [ { "id": "O60312", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60312" } ] }, { "ec_number": "7.6.2.1", "activity": "", "evidence": [ { "id": "O60312", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60312" } ] } ] }, { "uniprot_ac": "O70228", "gene_name": "Atp9a", "activity": [ { "ec_number": "7.6.2.1", "activity": "ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.", "evidence": [ { "id": "O70228", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70228" } ] }, { "ec_number": "7.6.2.1", "activity": "", "evidence": [ { "id": "O70228", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70228" } ] } ] }, { "uniprot_ac": "O94823", "gene_name": "ATP10B", "activity": [ { "ec_number": "7.6.2.1", "activity": "ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.", "evidence": [ { "id": "O94823", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O94823" } ] }, { "ec_number": "7.6.2.1", "activity": "", "evidence": [ { "id": "O94823", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O94823" } ] } ] }, { "uniprot_ac": "P32660", "gene_name": "DNF1", "activity": [ { "ec_number": "7.6.2.1", "activity": "ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.", "evidence": [ { "id": "P32660", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32660" } ] }, { "ec_number": "7.6.2.1", "activity": "", "evidence": [ { "id": "P32660", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32660" } ] } ] }, { "uniprot_ac": "P70704", "gene_name": "Atp8a1", "activity": [ { "ec_number": "7.6.2.1", "activity": "ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.", "evidence": [ { "id": "P70704", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P70704" } ] }, { "ec_number": "7.6.2.1", "activity": "", "evidence": [ { "id": "P70704", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P70704" } ] } ] }, { "uniprot_ac": "P98195", "gene_name": "Atp9b", "activity": [ { "ec_number": "7.6.2.1", "activity": "ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.", "evidence": [ { "id": "P98195", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P98195" } ] }, { "ec_number": "7.6.2.1", "activity": "", "evidence": [ { "id": "P98195", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P98195" } ] } ] }, { "uniprot_ac": "P98197", "gene_name": "Atp11a", "activity": [ { "ec_number": "7.6.2.1", "activity": "ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.", "evidence": [ { "id": "P98197", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P98197" } ] }, { "ec_number": "7.6.2.1", "activity": "", "evidence": [ { "id": "P98197", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P98197" } ] } ] }, { "uniprot_ac": "P98199", "gene_name": "Atp8b2", "activity": [ { "ec_number": "7.6.2.1", "activity": "ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.", "evidence": [ { "id": "P98199", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P98199" } ] }, { "ec_number": "7.6.2.1", "activity": "", "evidence": [ { "id": "P98199", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P98199" } ] } ] }, { "uniprot_ac": "P98200", "gene_name": "Atp8a2", "activity": [ { "ec_number": "7.6.2.1", "activity": "ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.", "evidence": [ { "id": "P98200", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P98200" } ] }, { "ec_number": "7.6.2.1", "activity": "", "evidence": [ { "id": "P98200", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P98200" } ] } ] }, { "uniprot_ac": "Q12675", "gene_name": "DNF2", "activity": [ { "ec_number": "7.6.2.1", "activity": "ATP + 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