{ "uniprot_canonical_ac": "A8DZ29-1", "uniprot_ac": "A8DZ29", "uniprot_id": "A8DZ29_DROME", "mass": { "chemical_mass": 211123.0, "monoisotopic_mass": 211123.0 }, "refseq": { "ac": "NP_001096852", "name": "eukaryotic translation initiation factor 4G1, isoform B", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001096852" }, "gene_names": [ { "name": "eIF4G1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A8DZ29", "id": "A8DZ29" }, { "name": "CG10811; deIF4G; Dmel\\CG10811; eIF-4G; eIF4g; eIF4G; Eif4G; EIF4G; EIF4G1; p200", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001096852", "id": "NP_001096852" }, { "name": "CG10811", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A8DZ29", "id": "A8DZ29" }, { "name": "Dmel\\CG10811", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A8DZ29", "id": "A8DZ29" }, { "name": "Dmel_CG10811", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A8DZ29", "id": "A8DZ29" }, { "name": "EIF4G", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A8DZ29", "id": "A8DZ29" }, { "name": "Eif4G", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A8DZ29", "id": "A8DZ29" }, { "name": "deIF4G", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A8DZ29", "id": "A8DZ29" }, { "name": "eIF-4G", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A8DZ29", "id": "A8DZ29" }, { "name": "eIF4G-RA", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A8DZ29", "id": "A8DZ29" }, { "name": "eIF4G1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001096852", "id": "NP_001096852" }, { "name": "eIF4G", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A8DZ29", "id": "A8DZ29" }, { "name": "eIF4g", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A8DZ29", "id": "A8DZ29" }, { "name": "p200", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A8DZ29", "id": "A8DZ29" } ], "protein_names": [ { "name": "CG10811-PB; eIF4G1-PB; eukaryotic initiation factor 4G; translation initiation factor 4G; eIF-4G; Eukaryotic-initiation-factor-4G; eukaryotic translation initiation factor 4G; translation initiation factor eIF4G", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001096852", "id": "NP_001096852" }, { "name": "CG10811-PC; eIF4G1-PC; eukaryotic initiation factor 4G; translation initiation factor 4G; eIF-4G; Eukaryotic-initiation-factor-4G; eukaryotic translation initiation factor 4G; translation initiation factor eIF4G", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001137857", "id": "NP_001137857" }, { "name": "Eukaryotic translation initiation factor 4G1, isoform B", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "A8DZ29" }, { "name": "eukaryotic translation initiation factor 4G1, isoform B", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001096852", "id": "NP_001096852" }, { "name": "eukaryotic translation initiation factor 4G1, isoform C", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001137857", "id": "NP_001137857" } ], "function": [], "disease": [ { "disease_id": "DOID:0060892", "recommended_name": { "id": "DOID:0060892", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0060892", "name": "late onset Parkinson's disease", "description": "A Parkinson's disease characterized by onset of motor symptoms typically after 60 years of age." }, "synonyms": [ { "id": "DOID:0060892", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0060892", "name": "late onset Parkinson disease", "description": "" }, { "id": "MONDO:0008199", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008199", "name": "late-onset Parkinson disease", "description": "A Parkinson disease that begins after around the age of 50." }, { "id": "MONDO:0008199", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008199", "name": "LOPD", "description": "" }, { "id": "MONDO:0008199", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008199", "name": "PARK", "description": "" }, { "id": "MONDO:0008199", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008199", "name": "PD", "description": "" }, { "id": "MONDO:0008199", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008199", "name": "Parkinson disease, age of onset, modifier, Multifactorial", "description": "" }, { "id": "MONDO:0008199", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008199", "name": "Parkinson disease, late-onset", "description": "" }, { "id": "MONDO:0008199", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008199", "name": "Parkinson disease, late-onset, susceptibility to, Multifactorial", "description": "" }, { "id": "MONDO:0008199", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008199", "name": "Parkinson disease, susceptibility to, Multifactorial", "description": "" }, { "id": "MONDO:0008199", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008199", "name": "autosomal dominant late-onset Parkinson disease", "description": "" }, { "id": "MONDO:0008199", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008199", "name": "hereditary late onset Parkinson disease", "description": "" }, { "id": "MONDO:0008199", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008199", "name": "hereditary late-onset Parkinson disease", "description": "" }, { "id": "MONDO:0008199", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008199", "name": "late onset Parkinson disease", "description": "" }, { "id": "MONDO:0008199", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008199", "name": "late onset Parkinson's disease", "description": "" }, { "id": "MONDO:0008199", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008199", "name": "late-onset Parkinson disease", "description": "" }, { "id": "MIM:168600", "resource": "MIM", "url": "https://www.omim.org/entry/168600", "name": "Parkinson disease", "description": "Parkinson disease" } ], "evidence": [ { "id": "0060892", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0060892" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "A8DZ29", "url": "https://www.uniprot.org/uniprot/A8DZ29" } ], "common_name": "Fruit fly" } ], "gene": [ { "name": "eIF4G1", "url": "https://www.uniprot.org/uniprot/A8DZ29", "locus": { "chromosome": "4", "start_pos": 915297, "end_pos": 930715, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "FBgn0023213", "url": "https://www.ensembl.org/id/FBgn0023213" } ] } } ], "crossref": [ { "id": "FBgn0023213", "url": "https://bgee.org/?page=gene&gene_id=FBgn0023213", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd11559", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11559", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "FBgn0023213", "url": "https://flybase.org/reports/FBgn0023213", "database": "FlyBase", "categories": [ "Organism-specific" ] }, { "id": "43839", "url": "https://www.ncbi.nlm.nih.gov/gene/43839", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "A8DZ29", "url": "https://www.ebi.ac.uk/intact/interactors/id:A8DZ29*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "O61380", "url": "https://www.ebi.ac.uk/intact/interactors/id:O61380*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR003307", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003307", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003890", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003890", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003891", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003891", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016024", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016024", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045208", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045208", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "dme:Dmel_CG10811", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+dme:Dmel_CG10811", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "A8DZ29", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=A8DZ29", "database": "O-GlcNAc Database", "categories": [ "Glycoproteomics" ] }, { "id": "CIKRIPE", "url": "https://omabrowser.org/oma/group/CIKRIPE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "92033at2759", "url": "http://www.orthodb.org/?query=92033at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23253", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23253", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23253:SF78", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23253:SF78", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "4UEC", "url": "https://www.rcsb.org/structure/4UEC", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "5T47", "url": "https://www.rcsb.org/structure/5T47", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "5T48", "url": "https://www.rcsb.org/structure/5T48", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF02847", "url": "http://pfam.xfam.org/family/PF02847", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF02854", "url": "http://pfam.xfam.org/family/PF02854", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "R-DME-1169408", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-1169408", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-DME-156827", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-156827", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-DME-166208", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-166208", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-DME-429947", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-429947", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-DME-450408", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-450408", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-DME-72649", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-72649", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-DME-72662", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-72662", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-DME-72702", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-72702", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-DME-975956", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-975956", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-DME-975957", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-975957", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_001096852", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001096852", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A8DZ29", "url": "https://www.uniprot.org/uniprot/A8DZ29", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A8DZ29-1", "url": "https://www.uniprot.org/uniprot/A8DZ29-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O61380", "url": "https://www.uniprot.org/uniprot/O61380", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O61380-1", "url": "https://www.uniprot.org/uniprot/O61380-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MQQAIPTLPTQSDIDKAMQPHSAQNMILPANKKTKKYDQQVPTSKPQSLHQPLQPQHSHPTAQPQFQINKAYNVVSILKASAQIAQQSPHLTNQQHPPIHHPQQTQQHQQSYTNVVNRSLSASEPVRAQSSVICNGSSILTVNSRQLNSGDMNSTAIYNISSYRKLTGSLDGNVCFLNVQDIKQNGNISGSVVSNKSIVGVGSEKSSCTGVSINNQIVLPNAQIGTSMGIAGTTTAGTSYMHEKNIVGVSVNCVNTSKKYDFNNSSLLSNNSYPASTAEYVSTGNNNSGNTRSNPQSGGIFRGPPSTPNAPRGASGGATRHVHVQPMYSQPLHQNMVLQQYTQYNPRQQTFPASHLQYAPAPMPYYQYQYVPTLQQQPPHTRSAVTVNTNVNVGNNLQPVQSGPNGPLPVPGASSSQIQLLTSTVQPGASTVMGVGGPGSTMGQVGVPPMVGVGVMTTSVQPQPVQVQPASRRRHQHRLQIIDPTTKKNILDDFDKTKSNTDNEFSDQVTSTNTPATVLSEGPIRIPQQESVGLNNLTSTSSQGSESRTNAPYIPIETTPISRTDVGPTPIVSAMTDAPSVEILPTPQRGRSKKIPIVSPKNVSESIVAPITDETDDAGSTPISRATEESMPPNQTHPNLLISDSSKHKQAVSNSEISKDAPTGLKEMHVAELESSVASENHPAGILDVNVNKSSQSLDFSADPEIDSIGAISPTSPNAVSPILHEVLDNTELSKKLENSTTERFKDSQSVEKPTHQELSLRNATDETEISAMALQDVNSLDNNQIEKTYPSKPKLNVDVSEDISSRESAIKSTSTKNTGVDVGLQSDSKPETTLNDKQDSTDLKVKVSAKISSIINYNEGQWSPNNPSGKKQYDREQLLQLREVKASRIQPEVKNVSILPQPNLMPSFIRNNNNNKRVQSMVGIIGNRSNESAGNYIGKQMSMSGVQSGGGRSSMKGMIHVNLSLNQDVKLSENENAWRPRVLNKSDGDSDAKSALEKDELVRRVRGILNKLTPERFDTLVEEIIKLKIDTPDKVDEVIVLVFEKAIDEPNFSVSYARLCQRLAAEVKVIDERMESETKSNSAHFRNALLDKTEQEFTQNVSQSTAKEKKLQPIVDKIKKCTDANEKAELEAFLEEEERKIRRRSGGTVRFIGELFKISMLTGKIIYSCIDTLLNPHSEDMLECLCKLLTTVGAKFEKTPVNSKDPSRCYSLEKSITRMQAIASKTDKDGARVSSRVRFMLQDVIDLRKNKWQTSRNEAPKTMGQIEKEAKNEQLSAQYFGTLSSTTPGGSQGGSGKRDDRGNSRYGESRSSSAYGGSHSQRGDNGNLRHQQQNNVGGNVSGGAGHSNGNNDENTWHVQTSKGSRSLAVDSNKLEGLSKLSDQNLETKKMGGLTQFIWISSDTTRLSSAPTPTPSNPFAVLSSLIDKNSNERDRDRSGPRNKGSYNKGSMERDRYDRGMHSRTGSSQGSRENSSSRGGQQGRTLLSSSVQKSTSHSKYTQQAPPTRHTVKAQSSVGSSNVNTGPLYRGSEQQTSATFSQTTRSVAPVAVFIEASETDLKLIKSVVSEIVDLSAASKEVTPGAVSCIKRVPEKLRCSFIYYILTDYLHLANVGKQYRRYLSIAVSQLIQQNYISADHLRLAYNEFTVYANDLIVDIPELWLYILQFAGPLIVKKILTISDLWNNNLKENSPSNVAKKFLKTYLIYCTQEVGPNFARNMWIKFNLKWSDFMPESEVADFIKFNRLEYVENESKSPVIDHRETPEKHVKNVIDHIEHLLKEGTTADCIIDYSNGNIMVVDKLFIRGLTETLSNFSIHYKDNSYKLESETFQKFCIPVLQRYIDSNEDHQLECLYTLQLLVHGLEHPRGLLSELIGELYDAFVIQKESLCKWRDSKDQSAGKGVAVKSLNPFFNSLLNDDAN", "length": 1919, "header": "tr|A8DZ29-1|A8DZ29_DROME Isoform 1 of Eukaryotic translation initiation factor 4G1, isoform B OS=Drosophila melanogaster OX=7227 GN=eIF4G1 PE=1 SV=1 CANONICAL=A8DZ29-1" }, "isoforms": [ { "isoform_ac": "A8DZ29-1", "url": "", "sequence": { "sequence": "MQQAIPTLPTQSDIDKAMQPHSAQNMILPANKKTKKYDQQVPTSKPQSLHQPLQPQHSHPTAQPQFQINKAYNVVSILKASAQIAQQSPHLTNQQHPPIHHPQQTQQHQQSYTNVVNRSLSASEPVRAQSSVICNGSSILTVNSRQLNSGDMNSTAIYNISSYRKLTGSLDGNVCFLNVQDIKQNGNISGSVVSNKSIVGVGSEKSSCTGVSINNQIVLPNAQIGTSMGIAGTTTAGTSYMHEKNIVGVSVNCVNTSKKYDFNNSSLLSNNSYPASTAEYVSTGNNNSGNTRSNPQSGGIFRGPPSTPNAPRGASGGATRHVHVQPMYSQPLHQNMVLQQYTQYNPRQQTFPASHLQYAPAPMPYYQYQYVPTLQQQPPHTRSAVTVNTNVNVGNNLQPVQSGPNGPLPVPGASSSQIQLLTSTVQPGASTVMGVGGPGSTMGQVGVPPMVGVGVMTTSVQPQPVQVQPASRRRHQHRLQIIDPTTKKNILDDFDKTKSNTDNEFSDQVTSTNTPATVLSEGPIRIPQQESVGLNNLTSTSSQGSESRTNAPYIPIETTPISRTDVGPTPIVSAMTDAPSVEILPTPQRGRSKKIPIVSPKNVSESIVAPITDETDDAGSTPISRATEESMPPNQTHPNLLISDSSKHKQAVSNSEISKDAPTGLKEMHVAELESSVASENHPAGILDVNVNKSSQSLDFSADPEIDSIGAISPTSPNAVSPILHEVLDNTELSKKLENSTTERFKDSQSVEKPTHQELSLRNATDETEISAMALQDVNSLDNNQIEKTYPSKPKLNVDVSEDISSRESAIKSTSTKNTGVDVGLQSDSKPETTLNDKQDSTDLKVKVSAKISSIINYNEGQWSPNNPSGKKQYDREQLLQLREVKASRIQPEVKNVSILPQPNLMPSFIRNNNNNKRVQSMVGIIGNRSNESAGNYIGKQMSMSGVQSGGGRSSMKGMIHVNLSLNQDVKLSENENAWRPRVLNKSDGDSDAKSALEKDELVRRVRGILNKLTPERFDTLVEEIIKLKIDTPDKVDEVIVLVFEKAIDEPNFSVSYARLCQRLAAEVKVIDERMESETKSNSAHFRNALLDKTEQEFTQNVSQSTAKEKKLQPIVDKIKKCTDANEKAELEAFLEEEERKIRRRSGGTVRFIGELFKISMLTGKIIYSCIDTLLNPHSEDMLECLCKLLTTVGAKFEKTPVNSKDPSRCYSLEKSITRMQAIASKTDKDGARVSSRVRFMLQDVIDLRKNKWQTSRNEAPKTMGQIEKEAKNEQLSAQYFGTLSSTTPGGSQGGSGKRDDRGNSRYGESRSSSAYGGSHSQRGDNGNLRHQQQNNVGGNVSGGAGHSNGNNDENTWHVQTSKGSRSLAVDSNKLEGLSKLSDQNLETKKMGGLTQFIWISSDTTRLSSAPTPTPSNPFAVLSSLIDKNSNERDRDRSGPRNKGSYNKGSMERDRYDRGMHSRTGSSQGSRENSSSRGGQQGRTLLSSSVQKSTSHSKYTQQAPPTRHTVKAQSSVGSSNVNTGPLYRGSEQQTSATFSQTTRSVAPVAVFIEASETDLKLIKSVVSEIVDLSAASKEVTPGAVSCIKRVPEKLRCSFIYYILTDYLHLANVGKQYRRYLSIAVSQLIQQNYISADHLRLAYNEFTVYANDLIVDIPELWLYILQFAGPLIVKKILTISDLWNNNLKENSPSNVAKKFLKTYLIYCTQEVGPNFARNMWIKFNLKWSDFMPESEVADFIKFNRLEYVENESKSPVIDHRETPEKHVKNVIDHIEHLLKEGTTADCIIDYSNGNIMVVDKLFIRGLTETLSNFSIHYKDNSYKLESETFQKFCIPVLQRYIDSNEDHQLECLYTLQLLVHGLEHPRGLLSELIGELYDAFVIQKESLCKWRDSKDQSAGKGVAVKSLNPFFNSLLNDDAN", "length": 1919, "header": "tr|A8DZ29-1|A8DZ29_DROME Isoform 1 of Eukaryotic translation initiation factor 4G1, isoform B OS=Drosophila melanogaster OX=7227 GN=eIF4G1 PE=1 SV=1 CANONICAL=A8DZ29-1" }, "locus": { "chromosome": "4", "start_pos": 929899, "end_pos": 915495, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "FBtr0112904", "url": "https://www.ensembl.org/id/FBtr0112904" }, { "database": "Ensembl Peptide", "id": "FBpp0111817", "url": "https://www.ensembl.org/id/FBpp0111817" } ] } }, { "isoform_ac": "O61380-1", "url": "", "sequence": { "sequence": 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"length": 1666, "header": "tr|O61380-1|O61380_DROME Computationally mapped isoform of FI02056p OS=Drosophila melanogaster OX=7227 GN=eIF4G1 PE=1 SV=3 CANONICAL=A8DZ29-1" }, "locus": { "chromosome": "4", "start_pos": 929899, "end_pos": 915495, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "FBtr0289951", "url": "https://www.ensembl.org/id/FBtr0289951" }, { "database": "Ensembl Peptide", "id": "FBpp0288389", "url": "https://www.ensembl.org/id/FBpp0288389" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "", "relation": "attached", "comment": "O-GlcNAcylation", "evidence": [ { "id": "A8DZ29", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=A8DZ29" }, { "id": "33925313", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/33925313" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "The genome sequence of Drosophila melanogaster.", "journal": "Science", "date": "2000", "authors": "Adams MD, Celniker SE, Holt RA, Evans CA, Gocayne JD, Amanatides PG, Scherer SE, Li PW, Hoskins RA, Galle RF, George RA, Lewis SE, Richards S, Ashburner M, Henderson SN, Sutton GG, Wortman JR, Yandell MD, Zhang Q, Chen LX, Brandon RC, Rogers YH, Blazej RG, Champe M, Pfeiffer BD, Wan KH, Doyle C, Baxter EG, Helt G, Nelson CR, Gabor GL, Abril JF, Agbayani A, An HJ, Andrews-Pfannkoch C, Baldwin D, Ballew RM, Basu A, Baxendale J, Bayraktaroglu L, Beasley EM, Beeson KY, Benos PV, Berman BP, Bhandari D, Bolshakov S, Borkova D, Botchan MR, Bouck J, Brokstein P, Brottier P, Burtis KC, Busam DA, Butler H, Cadieu E, Center A, Chandra I, Cherry JM, Cawley S, Dahlke C, Davenport LB, Davies P, de Pablos B, Delcher A, Deng Z, Mays AD, Dew I, Dietz SM, Dodson K, Doup LE, Downes M, Dugan-Rocha S, Dunkov BC, Dunn P, Durbin KJ, Evangelista CC, Ferraz C, Ferriera S, Fleischmann W, Fosler C, Gabrielian AE, Garg NS, Gelbart WM, Glasser K, Glodek A, Gong F, Gorrell JH, Gu Z, Guan P, Harris M, Harris NL, Harvey D, Heiman TJ, Hernandez JR, Houck J, Hostin D, Houston KA, Howland TJ, Wei MH, Ibegwam C, Jalali M, Kalush F, Karpen GH, Ke Z, Kennison JA, Ketchum KA, Kimmel BE, Kodira CD, Kraft C, Kravitz S, Kulp D, Lai Z, Lasko P, Lei Y, Levitsky AA, Li J, Li Z, Liang Y, Lin X, Liu X, Mattei B, McIntosh TC, McLeod MP, McPherson D, Merkulov G, Milshina NV, Mobarry C, Morris J, Moshrefi A, Mount SM, Moy M, Murphy B, Murphy L, Muzny DM, Nelson DL, Nelson DR, Nelson KA, Nixon K, Nusskern DR, Pacleb JM, Palazzolo M, Pittman GS, Pan S, Pollard J, Puri V, Reese MG, Reinert K, Remington K, Saunders RD, Scheeler F, Shen H, Shue BC, Siden-Kiamos I, Simpson M, Skupski MP, Smith T, Spier E, Spradling AC, Stapleton M, Strong R, Sun E, Svirskas R, Tector C, Turner R, Venter E, Wang AH, Wang X, Wang ZY, Wassarman DA, Weinstock GM, Weissenbach J, Williams SM, WoodageT, Worley KC, Wu D, Yang S, Yao QA, Ye J, Yeh RF, Zaveri JS, Zhan M, Zhang G, Zhao Q, Zheng L, Zheng XH, Zhong FN, Zhong W, Zhou X, Zhu S, Zhu X, Smith HO, Gibbs RA, Myers EW, Rubin GM, Venter JC", "evidence": [ { "database": "UniProtKB", "id": "A8DZ29", "url": "https://www.uniprot.org/uniprot/A8DZ29" }, { "database": "UniProtKB", "id": "O61380", "url": "https://www.uniprot.org/uniprot/O61380" } ], "reference": [ { "type": "PubMed", "id": "10731132", "url": "https://glygen.org/publication/PubMed/10731132" } ] }, { "title": "Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence.", "journal": "Genome Biol.", "date": "2002", "authors": "Celniker SE, Wheeler DA, Kronmiller B, Carlson JW, Halpern A, Patel S, Adams M, Champe M, Dugan SP, Frise E, Hodgson A, George RA, Hoskins RA, Laverty T, Muzny DM, Nelson CR, Pacleb JM, Park S, Pfeiffer BD, Richards S, Sodergren EJ, Svirskas R, Tabor PE, Wan K, Stapleton M, Sutton GG, Venter C, Weinstock G, Scherer SE, Myers EW, Gibbs RA, Rubin GM", "evidence": [ { "database": "UniProtKB", "id": "A8DZ29", "url": "https://www.uniprot.org/uniprot/A8DZ29" }, { "database": "UniProtKB", "id": "O61380", "url": "https://www.uniprot.org/uniprot/O61380" } ], "reference": [ { "type": "PubMed", "id": "12537568", "url": "https://glygen.org/publication/PubMed/12537568" } ] }, { "title": "Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.", "journal": "Genome Biol.", "date": "2002", "authors": "Misra S, Crosby MA, Mungall CJ, Matthews BB, Campbell KS, Hradecky P, Huang Y, Kaminker JS, Millburn GH, Prochnik SE, Smith CD, Tupy JL, Whitfied EJ, Bayraktaroglu L, Berman BP, Bettencourt BR, Celniker SE, de Grey AD, Drysdale RA, Harris NL, Richter J, Russo S, Schroeder AJ, Shu SQ, Stapleton M, Yamada C, Ashburner M, Gelbart WM, Rubin GM, Lewis SE", "evidence": [ { "database": "UniProtKB", "id": "A8DZ29", "url": "https://www.uniprot.org/uniprot/A8DZ29" }, { "database": "UniProtKB", "id": "O61380", "url": "https://www.uniprot.org/uniprot/O61380" } ], "reference": [ { "type": "PubMed", "id": "12537572", "url": "https://glygen.org/publication/PubMed/12537572" } ] }, { "title": "The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective.", "journal": "Genome Biol.", "date": "2002", "authors": "Kaminker JS, Bergman CM, Kronmiller B, Carlson J, Svirskas R, Patel S, Frise E, Wheeler DA, Lewis SE, Rubin GM, Ashburner M, Celniker SE", "evidence": [ { "database": "UniProtKB", "id": "A8DZ29", "url": "https://www.uniprot.org/uniprot/A8DZ29" }, { "database": "UniProtKB", "id": "O61380", "url": "https://www.uniprot.org/uniprot/O61380" } ], "reference": [ { "type": "PubMed", "id": "12537573", "url": "https://glygen.org/publication/PubMed/12537573" } ] }, { "title": "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly.", "journal": "Genome Biol.", "date": "2002", "authors": "Hoskins RA, Smith CD, Carlson JW, Carvalho AB, Halpern A, Kaminker JS, Kennedy C, Mungall CJ, Sullivan BA, Sutton GG, Yasuhara JC, Wakimoto BT, Myers EW, Celniker SE, Rubin GM, Karpen GH", "evidence": [ { "database": "UniProtKB", "id": "A8DZ29", "url": "https://www.uniprot.org/uniprot/A8DZ29" }, { "database": "UniProtKB", "id": "O61380", "url": "https://www.uniprot.org/uniprot/O61380" } ], "reference": [ { "type": "PubMed", "id": "12537574", "url": "https://glygen.org/publication/PubMed/12537574" } ] }, { "title": "Combined evidence annotation of transposable elements in genome sequences.", "journal": "PLoS Comput. Biol.", "date": "2005", "authors": "Quesneville H, Bergman CM, Andrieu O, Autard D, Nouaud D, Ashburner M, Anxolabehere D", "evidence": [ { "database": "UniProtKB", "id": "A8DZ29", "url": "https://www.uniprot.org/uniprot/A8DZ29" }, { "database": "UniProtKB", "id": "O61380", "url": "https://www.uniprot.org/uniprot/O61380" } ], "reference": [ { "type": "PubMed", "id": "16110336", "url": "https://glygen.org/publication/PubMed/16110336" } ] }, { "title": "The Release 5.1 annotation of Drosophila melanogaster heterochromatin.", "journal": "Science", "date": "2007", "authors": "Smith CD, Shu S, Mungall CJ, Karpen GH", "evidence": [ { "database": "UniProtKB", "id": "A8DZ29", "url": "https://www.uniprot.org/uniprot/A8DZ29" }, { "database": "UniProtKB", "id": "O61380", "url": "https://www.uniprot.org/uniprot/O61380" } ], "reference": [ { "type": "PubMed", "id": "17569856", "url": "https://glygen.org/publication/PubMed/17569856" } ] }, { "title": "Sequence finishing and mapping of Drosophila melanogaster heterochromatin.", "journal": "Science", "date": "2007", "authors": "Hoskins RA, Carlson JW, Kennedy C, Acevedo D, Evans-Holm M, Frise E, Wan KH, Park S, Mendez-Lago M, Rossi F, Villasante A, Dimitri P, Karpen GH, Celniker SE", "evidence": [ { "database": "UniProtKB", "id": "A8DZ29", "url": "https://www.uniprot.org/uniprot/A8DZ29" }, { "database": "UniProtKB", "id": "O61380", "url": "https://www.uniprot.org/uniprot/O61380" } ], "reference": [ { "type": "PubMed", "id": "17569867", "url": "https://glygen.org/publication/PubMed/17569867" } ] }, { "title": "The Release 6 reference sequence of the Drosophila melanogaster genome.", "journal": "Genome Res.", "date": "2015", "authors": "Hoskins RA, Carlson JW, Wan KH, Park S, Mendez I, Galle SE, Booth BW, Pfeiffer BD, George RA, Svirskas R, Krzywinski M, Schein J, Accardo MC, Damia E, Messina G, Mendez-Lago M, de Pablos B, Demakova OV, Andreyeva EN, Boldyreva LV, Marra M, Carvalho AB, Dimitri P, Villasante A, Zhimulev IF, Rubin GM, Karpen GH, Celniker SE", "evidence": [ { "database": "UniProtKB", "id": "O61380", "url": "https://www.uniprot.org/uniprot/O61380" } ], "reference": [ { "type": "PubMed", "id": "25589440", "url": "https://glygen.org/publication/PubMed/25589440" } ] }, { "title": "Molecular architecture of 4E-BP translational inhibitors bound to eIF4E.", "journal": "Mol. Cell", "date": "2015", "authors": "Peter D, Igreja C, Weber R, Wohlbold L, Weiler C, Ebertsch L, Weichenrieder O, Izaurralde E", "evidence": [ { "database": "UniProtKB", "id": "O61380", "url": "https://www.uniprot.org/uniprot/O61380" } ], "reference": [ { "type": "PubMed", "id": "25702871", "url": "https://glygen.org/publication/PubMed/25702871" } ] }, { "title": "Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.", "journal": "G3 (Bethesda)", "date": "2015", "authors": "Crosby MA, Gramates LS, Dos Santos G, Matthews BB, St Pierre SE, Zhou P, Schroeder AJ, Falls K, Emmert DB, Russo SM, Gelbart WM", "evidence": [ { "database": "UniProtKB", "id": "O61380", "url": "https://www.uniprot.org/uniprot/O61380" } ], "reference": [ { "type": "PubMed", "id": "26109356", "url": "https://glygen.org/publication/PubMed/26109356" } ] }, { "title": "Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.", "journal": "G3 (Bethesda)", "date": "2015", "authors": "Matthews BB, Dos Santos G, Crosby MA, Emmert DB, St Pierre SE, Gramates LS, Zhou P, Schroeder AJ, Falls K, Strelets V, Russo SM, Gelbart WM", "evidence": [ { "database": "UniProtKB", "id": "O61380", "url": "https://www.uniprot.org/uniprot/O61380" } ], "reference": [ { "type": "PubMed", "id": "26109357", "url": "https://glygen.org/publication/PubMed/26109357" } ] }, { "title": "The Structures of eIF4E-eIF4G Complexes Reveal an Extended Interface to Regulate Translation Initiation.", "journal": "Mol. Cell", "date": "2016", "authors": "Izaurralde E., Wohlbold L., Weber R., Weichenrieder O., Chung M.Y., Igreja C., Valkov E., Peter D., Gruner S.", "evidence": [ { "database": "UniProtKB", "id": "O61380", "url": "https://www.uniprot.org/uniprot/O61380" } ], "reference": [ { "type": "PubMed", "id": "27773676", "url": "https://glygen.org/publication/PubMed/27773676" } ] }, { "title": "Drosophila O-GlcNAcase Mutants Reveal an Expanded Glycoproteome and Novel Growth and Longevity Phenotypes.", "journal": "Cells", "date": "2021", "authors": "Akan I, Halim A, Vakhrushev SY, Clausen H, Hanover JA", "evidence": [ { "database": "O-GlcNAc Database", "id": "A8DZ29", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=A8DZ29" } ], "reference": [ { "type": "PubMed", "id": "33925313", "url": "https://glygen.org/publication/PubMed/33925313" } ] }, { "title": "Isolation and characterization of the cDNA and the gene for eukaryotic translation initiation factor 4G from Drosophila melanogaster.", "journal": "Eur. 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Biochem.", "date": "1998", "authors": "Sierra J.M., Agudo M., Hernandez G., del Mar Castellano M.", "evidence": [ { "database": "UniProtKB", "id": "O61380", "url": "https://www.uniprot.org/uniprot/O61380" } ], "reference": [ { "type": "PubMed", "id": "9578457", "url": "https://glygen.org/publication/PubMed/9578457" } ] } ], "pathway": [ { "id": "dme:Dmel_CG10811", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+dme:Dmel_CG10811", "resource": "KEGG Pathway" }, { "id": "R-DME-1169408", "name": "ISG15 antiviral mechanism", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-1169408", "resource": "Reactome", "description": "ISG15 antiviral mechanism" }, { "id": "R-DME-156827", "name": "L13a-mediated translational silencing of Ceruloplasmin expression", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-156827", "resource": "Reactome", "description": "L13a-mediated translational silencing of Ceruloplasmin expression" }, { "id": "R-DME-166208", "name": "mTORC1-mediated signalling", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-166208", "resource": "Reactome", "description": "mTORC1-mediated signalling" }, { "id": "R-DME-429947", "name": "Deadenylation of mRNA", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-429947", "resource": "Reactome", "description": "Deadenylation of mRNA" }, { "id": "R-DME-450408", "name": "AUF1 (hnRNP D0) binds and destabilizes mRNA", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-450408", "resource": "Reactome", "description": "AUF1 (hnRNP D0) binds and destabilizes mRNA" }, { "id": "R-DME-72649", "name": "Translation initiation complex formation", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-72649", "resource": "Reactome", "description": "Translation initiation complex formation" }, { "id": "R-DME-72662", "name": "Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S", "url": 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