{
    "uniprot_canonical_ac": "A6IJH3-1",
    "uniprot_ac": "A6IJH3",
    "uniprot_id": "A6IJH3_RAT",
    "mass": {
        "chemical_mass": 55332.0,
        "monoisotopic_mass": 55332.0
    },
    "refseq": {
        "ac": "NP_001121759",
        "name": "O-phosphoseryl-tRNA(Sec) selenium transferase",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001121759"
    },
    "gene_names": [
        {
            "name": "LOC679383",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/A6IJH3",
            "id": "A6IJH3"
        },
        {
            "name": "Sepsecs",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001121759",
            "id": "NP_001121759"
        },
        {
            "name": "Sepsecs",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A6IJH3",
            "id": "A6IJH3"
        }
    ],
    "protein_names": [
        {
            "name": "O-phosphoseryl-tRNA(Sec) selenium transferase",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "",
            "id": "A6IJH3"
        },
        {
            "name": "2.9.1.2",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "A6IJH3"
        },
        {
            "name": "O-phosphoseryl-tRNA(Sec) selenium transferase",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001121759",
            "id": "NP_001121759"
        },
        {
            "name": "Selenocysteine synthase",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "A6IJH3"
        },
        {
            "name": "Selenocysteinyl-tRNA(Sec) synthase",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "A6IJH3"
        },
        {
            "name": "Sep-tRNA:Sec-tRNA synthase",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "A6IJH3"
        }
    ],
    "function": [
        {
            "annotation": "Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A6IJH3",
                    "url": "https://www.uniprot.org/uniprot/A6IJH3#function"
                },
                {
                    "database": "UniProtKB",
                    "id": "PIRNR017689",
                    "url": "https://www.uniprot.org/uniprot/PIRNR017689#function"
                },
                {
                    "database": "UniProtKB",
                    "id": "ARBA00002552",
                    "url": "https://www.uniprot.org/uniprot/ARBA00002552#function"
                }
            ]
        }
    ],
    "disease": [
        {
            "disease_id": "DOID:0060270",
            "recommended_name": {
                "id": "DOID:0060270",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:0060270",
                "name": "pontocerebellar hypoplasia type 2D",
                "description": "A pontocerebellar hypoplasia that is characterized by progressive microcephaly, profound intellectual disability, spasticity and seizure, has_material_basis_in autosomal recessive inheritance of mutation in the SEPSECS gene."
            },
            "synonyms": [
                {
                    "id": "MONDO:0013438",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0013438",
                    "name": "pontocerebellar hypoplasia type 2D",
                    "description": "Any non-syndromic pontocerebellar hypoplasia in which the cause of the disease is a mutation in the SEPSECS gene."
                },
                {
                    "id": "MONDO:0013438",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0013438",
                    "name": "SEPSECS non-syndromic pontocerebellar hypoplasia",
                    "description": ""
                },
                {
                    "id": "MONDO:0013438",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0013438",
                    "name": "non-syndromic pontocerebellar hypoplasia caused by mutation in SEPSECS",
                    "description": ""
                },
                {
                    "id": "MONDO:0013438",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0013438",
                    "name": "pontocerebellar hypoplasia type 2D",
                    "description": ""
                },
                {
                    "id": "MONDO:0013438",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0013438",
                    "name": "Cerebellocerebral atrophy, progressive",
                    "description": ""
                },
                {
                    "id": "MONDO:0013438",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0013438",
                    "name": "PCH2D",
                    "description": ""
                },
                {
                    "id": "MONDO:0013438",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0013438",
                    "name": "cerebello-cerebral atrophy, progressive",
                    "description": ""
                },
                {
                    "id": "MONDO:0013438",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0013438",
                    "name": "pontocerebellar hypoplasia, type 2D",
                    "description": ""
                },
                {
                    "id": "MIM:613811",
                    "resource": "MIM",
                    "url": "https://www.omim.org/entry/613811",
                    "name": "Pontocerebellar hypoplasia 2D",
                    "description": "Pontocerebellar hypoplasia 2D"
                }
            ],
            "evidence": [
                {
                    "id": "0060270",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:0060270"
                }
            ]
        }
    ],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Rattus norvegicus",
            "taxid": 10116,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A6IJH3",
                    "url": "https://www.uniprot.org/uniprot/A6IJH3"
                }
            ],
            "common_name": "Rat"
        }
    ],
    "gene": [
        {
            "name": "LOC679383",
            "url": "https://www.uniprot.org/uniprot/A6IJH3",
            "locus": {}
        }
    ],
    "crossref": [
        {
            "id": "ENSRNOG00000049244",
            "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000049244",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "679383",
            "url": "https://www.ncbi.nlm.nih.gov/gene/679383",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "IPR008829",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR008829",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR015421",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR015421",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR015424",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR015424",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR019872",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR019872",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "rno:679383",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:679383",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "MSHANDY",
            "url": "https://omabrowser.org/oma/group/MSHANDY/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "121300at2759",
            "url": "http://www.orthodb.org/?query=121300at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR12944",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12944",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR12944:SF2",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12944:SF2",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF05889",
            "url": "http://pfam.xfam.org/family/PF05889",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "NP_001121759",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001121759",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "1589491",
            "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1589491",
            "database": "RGD",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "25041",
            "url": "https://www.rhea-db.org/rhea/25041",
            "database": "Rhea",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "A6IJH3",
            "url": "https://www.uniprot.org/uniprot/A6IJH3",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A6IJH3-1",
            "url": "https://www.uniprot.org/uniprot/A6IJH3-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MNPESFAAGERRVTPAYVRQGCEARRAHEHLIWLLIEQGKCPEDGWDESTLELFLHELAVMDSNNFLGNCGVGEREGRVASALVARRHYRFIHGIGRSGDISAVQPKAAGSSLLNKITNSLVLNVIKLAGVHSVASCFVVPMATGMSLTLCFLTLRHKRPKAKYIIWPRIDQKSCFKSMVTAGFEPVVIENVLEGDELRTDLKAVEAKIQELGPEHILCLHSTTACFAPRVPDRLEELAVICANYDIPHVVNNAYGLQSSKCMHLIQQGARVGRIDVFVQSLDKNFMVPVGGAIIAGFNDSFIQEISKMYPGRASASPSLDVLITLLSLGCNGYKKLLKERKEMFAYLSTQLQKLAEAHNERLLKTPHNPISLAMTLETLDGHQDRAVTQLGSMLFTRQVSGARAVPLGSVQTVSGHTFRGFMSHTDNYPCAYLNAAAAIGMKVQDVDLFIKRLDKCLNTVRKEQRKASAVSGADGNKAEDADVEEMALKLDDVLGHVDRGPAL",
        "length": 504,
        "header": "tr|A6IJH3-1|A6IJH3_RAT Isoform 1 of O-phosphoseryl-tRNA(Sec) selenium transferase  OS=Rattus norvegicus OX=10116 GN=LOC679383 PE=1 SV=1 CANONICAL=A6IJH3-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A6IJH3-1",
            "url": "",
            "sequence": {
                "sequence": "MNPESFAAGERRVTPAYVRQGCEARRAHEHLIWLLIEQGKCPEDGWDESTLELFLHELAVMDSNNFLGNCGVGEREGRVASALVARRHYRFIHGIGRSGDISAVQPKAAGSSLLNKITNSLVLNVIKLAGVHSVASCFVVPMATGMSLTLCFLTLRHKRPKAKYIIWPRIDQKSCFKSMVTAGFEPVVIENVLEGDELRTDLKAVEAKIQELGPEHILCLHSTTACFAPRVPDRLEELAVICANYDIPHVVNNAYGLQSSKCMHLIQQGARVGRIDVFVQSLDKNFMVPVGGAIIAGFNDSFIQEISKMYPGRASASPSLDVLITLLSLGCNGYKKLLKERKEMFAYLSTQLQKLAEAHNERLLKTPHNPISLAMTLETLDGHQDRAVTQLGSMLFTRQVSGARAVPLGSVQTVSGHTFRGFMSHTDNYPCAYLNAAAAIGMKVQDVDLFIKRLDKCLNTVRKEQRKASAVSGADGNKAEDADVEEMALKLDDVLGHVDRGPAL",
                "length": 504,
                "header": "tr|A6IJH3-1|A6IJH3_RAT Isoform 1 of O-phosphoseryl-tRNA(Sec) selenium transferase  OS=Rattus norvegicus OX=10116 GN=LOC679383 PE=1 SV=1 CANONICAL=A6IJH3-1"
            },
            "locus": {
                "chromosome": "14",
                "start_pos": 58339720,
                "end_pos": 58311549,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000070892.3",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000070892.3"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000065651.1",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000065651.1"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [
        "enzyme"
    ],
    "publication": [
        {
            "title": "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.",
            "journal": "Nat. Commun.",
            "date": "2012",
            "authors": "Lundby A, Secher A, Lage K, Nordsborg NB, Dmytriyev A, Lundby C, Olsen JV",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A6IJH3",
                    "url": "https://www.uniprot.org/uniprot/A6IJH3"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "22673903",
                    "url": "https://glygen.org/publication/PubMed/22673903"
                }
            ]
        }
    ],
    "pathway": [
        {
            "id": "rno:679383",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:679383",
            "resource": "KEGG Pathway"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "Q6P6M7-1",
            "protein_name": "O-phosphoseryl-tRNA(Sec) selenium transferase",
            "gene_name": "Sepsecs",
            "tax_id": 10090,
            "organism": "Mus musculus",
            "sequence": {
                "sequence": "MNPESFAAGERRVSPAYVRQGCEARRAHEHLIRLLLEQGKCPEDGWDESTLELFLHELAVMDSNNFLGNCGVGEREGRVASALVARRHYRFIHGIGRSGDISAVQPKAAGSSLLNKITNSLVLNVIKLAGVHSVASCFVVPMATGMSLTLCFLTLRHKRPKAKYIIWPRIDQKSCFKSMVTAGFEPVVIENVLEGDELRTDLKAVEAKIQELGPEHILCLHSTTACFAPRVPDRLEELAVICANYDIPHVVNNAYGLQSSKCMHLIQQGARVGRIDAFVQSLDKNFMVPVGGAIIAGFNEPFIQDISKMYPGRASASPSLDVLITLLSLGCSGYRKLLKERKEMFVYLSTQLKKLAEAHNERLLQTPHNPISLAMTLKTIDGHHDKAVTQLGSMLFTRQVSGARAVPLGNVQTVSGHTFRGFMSHADNYPCAYLNAAAAIGMKMQDVDLFIKRLDKCLNIVRKEQTRASVVSGADRNKAEDADIEEMALKLDDVLGDVGQGPAL",
                "length": 504
            },
            "evidence": [
                {
                    "id": "45232678",
                    "url": "http://www.informatics.jax.org/homology/45232678",
                    "database": "MGI"
                }
            ],
            "common_name": "Mouse"
        },
        {
            "uniprot_canonical_ac": "Q9HD40-1",
            "protein_name": "O-phosphoseryl-tRNA(Sec) selenium transferase",
            "gene_name": "SEPSECS",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MNRESFAAGERLVSPAYVRQGCEARRSHEHLIRLLLEKGKCPENGWDESTLELFLHELAIMDSNNFLGNCGVGEREGRVASALVARRHYRFIHGIGRSGDISAVQPKAAGSSLLNKITNSLVLDIIKLAGVHTVANCFVVPMATGMSLTLCFLTLRHKRPKAKYIIWPRIDQKSCFKSMITAGFEPVVIENVLEGDELRTDLKAVEAKVQELGPDCILCIHSTTSCFAPRVPDRLEELAVICANYDIPHIVNNAYGVQSSKCMHLIQQGARVGRIDAFVQSLDKNFMVPVGGAIIAGFNDSFIQEISKMYPGRASASPSLDVLITLLSLGSNGYKKLLKERKEMFSYLSNQIKKLSEAYNERLLHTPHNPISLAMTLKTLDEHRDKAVTQLGSMLFTRQVSGARVVPLGSMQTVSGYTFRGFMSHTNNYPCAYLNAASAIGMKMQDVDLFIKRLDRCLKAVRKERSKESDDNYDKTEDVDIEEMALKLDNVLLDTYQDASS",
                "length": 501
            },
            "evidence": [
                {
                    "id": "45232678",
                    "url": "http://www.informatics.jax.org/homology/45232678",
                    "database": "MGI"
                }
            ],
            "common_name": "Human"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Biological Process",
                "total": 2,
                "go_terms": [
                    {
                        "name": "selenocysteine incorporation",
                        "id": "GO:0001514",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001514",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A6IJH3",
                                "url": "https://www.uniprot.org/uniprot/A6IJH3"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "conversion of seryl-tRNAsec to selenocys-tRNAsec",
                        "id": "GO:0001717",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001717",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A6IJH3",
                                "url": "https://www.uniprot.org/uniprot/A6IJH3"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Cellular Component",
                "total": 2,
                "go_terms": [
                    {
                        "name": "nucleus",
                        "id": "GO:0005634",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A6IJH3",
                                "url": "https://www.uniprot.org/uniprot/A6IJH3"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cytoplasm",
                        "id": "GO:0005737",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A6IJH3",
                                "url": "https://www.uniprot.org/uniprot/A6IJH3"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Molecular Function",
                "total": 2,
                "go_terms": [
                    {
                        "name": "tRNA binding",
                        "id": "GO:0000049",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000049",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A6IJH3",
                                "url": "https://www.uniprot.org/uniprot/A6IJH3"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "phosphoseryl-selenocysteinyl-tRNA selenium transferase activity",
                        "id": "GO:0098621",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098621",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A6IJH3",
                                "url": "https://www.uniprot.org/uniprot/A6IJH3"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            }
        ]
    },
    "pro_annotation": [],
    "site_annotation": [
        {
            "start_pos": 299,
            "end_pos": 301,
            "annotation": "n_glycosylation_sequon"
        }
    ],
    "ptm_annotation": [],
    "interactions": [],
    "reactions": [
        {
            "id": "25041",
            "name": "",
            "equation": "H2O + O-phospho-L-seryl-tRNA(Sec) + selenophosphate = L-selenocysteinyl-tRNA(Sec) + 2 phosphate",
            "summary": "",
            "cellular_location": "",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "A6IJH3-1",
                "Q9HD40-1",
                "Q6P6M7-1",
                "Q54VQ6-1",
                "Q9VNE3-1"
            ],
            "evidence": [
                {
                    "id": "25041",
                    "database": "Rhea",
                    "url": "https://www.rhea-db.org/rhea/25041"
                }
            ]
        }
    ],
    "reaction_participants": [],
    "reaction_enzymes": [
        {
            "uniprot_ac": "A6IJH3",
            "gene_name": "LOC679383",
            "activity": [
                {
                    "ec_number": "2.9.1.2",
                    "activity": "H2O + O-phospho-L-seryl-tRNA(Sec) + selenophosphate = L-selenocysteinyl-tRNA(Sec) + 2 phosphate.",
                    "evidence": [
                        {
                            "id": "A6IJH3",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/A6IJH3"
                        }
                    ]
                },
                {
                    "ec_number": "2.9.1.2",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "A6IJH3",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/A6IJH3"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q54VQ6",
            "gene_name": "sepsecs",
            "activity": [
                {
                    "ec_number": "2.9.1.2",
                    "activity": "H2O + O-phospho-L-seryl-tRNA(Sec) + selenophosphate = L-selenocysteinyl-tRNA(Sec) + 2 phosphate.",
                    "evidence": [
                        {
                            "id": "Q54VQ6",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q54VQ6"
                        }
                    ]
                },
                {
                    "ec_number": "2.9.1.2",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q54VQ6",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q54VQ6"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q6P6M7",
            "gene_name": "Sepsecs",
            "activity": [
                {
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