{ "uniprot_canonical_ac": "A2AEY4-1", "uniprot_ac": "A2AEY4", "uniprot_id": "MA7D3_MOUSE", "mass": { "chemical_mass": 98230.0, "monoisotopic_mass": 98230.0 }, "refseq": {}, "gene_names": [ { "name": "Map7d3", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A2AEY4", "id": "A2AEY4" }, { "name": "Mdp3", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A2AEY4", "id": "A2AEY4" }, { "name": "Mtap7d3", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A2AEY4", "id": "A2AEY4" } ], "protein_names": [ { "name": "MAP7 domain-containing protein 3", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "A2AEY4" } ], "function": [ { "annotation": "Promotes the assembly and stability of microtubules.", "evidence": [ { "database": "UniProtKB", "id": "A2AEY4", "url": "https://www.uniprot.org/uniprot/A2AEY4#function" }, { "database": "UniProtKB", "id": "Q8IWC1", "url": "https://www.uniprot.org/uniprot/Q8IWC1#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "A2AEY4", "url": "https://www.uniprot.org/uniprot/A2AEY4" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Map7d3", "url": "https://www.uniprot.org/uniprot/A2AEY4", "locus": { "chromosome": "X", "start_pos": 55843218, "end_pos": 55867686, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000067878", "url": "https://www.ensembl.org/id/ENSMUSG00000067878" } ] } } ], "crossref": [ { "id": "ENSMUSG00000067878", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000067878", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "mmu:320923", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:320923", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "2445051", "url": "http://www.informatics.jax.org/marker/MGI:2445051", "database": "MGI", "categories": [ "Organism-specific" ] }, { "id": "CDMKTFR", "url": "https://omabrowser.org/oma/group/CDMKTFR/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "5362734at2759", "url": "http://www.orthodb.org/?query=5362734at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15073", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15073", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15073:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15073:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PR_A2AEY4", "url": "http://purl.obolibrary.org/obo/PR_A2AEY4", "database": "PRO", "categories": [ "Protein" ] }, { "id": "A0A0R4J1R4", "url": "https://www.uniprot.org/uniprot/A0A0R4J1R4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0R4J1R4-1", "url": "https://www.uniprot.org/uniprot/A0A0R4J1R4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A2AEY4", "url": "https://www.uniprot.org/uniprot/A2AEY4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A2AEY4-1", "url": "https://www.uniprot.org/uniprot/A2AEY4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A2AEY4-2", "url": "https://www.uniprot.org/uniprot/A2AEY4-2", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MADPTFAATSSSTSFRGLHERLVAMTQELAEERRHKRGINSSAGANKRSSSTPDGSVLKNDVKQQLAKERREQQKRQQEANKEKQLLEKEQKAKLQYEKQLEEKHRKLKEQKEKDQRRQASAEEKRKQKQAEDTEKFKAVVSRTLERCNRIDQRQKRWSWEGGVMNADKSGKLENKRSSSLSRKDNRLHPRGDMQHVDNTPGMTKYVFRYVTAPVFSSDEIKSSAMFCKPSAKTPVAAKLEKITTKKLDASLRGHVEGLSMMNIEIPPKITIEVPSPPKLEESSEADAEVRLQTMDDISKVKEDASQKVDIKVPTDENIARHPKPNVEELSPVSVDTSSSVELSSIVSVNSSPSLSTGSFSFGSVEISPVVSIDASLETNIDTSPELSMDSGNTKVASEIKTEAPLQARGESRLEASVEGQPEANVEGSPKNPEIDKRNINLTTKKQPLCHIPCYRWPSSSALGCRPPSPLKALQTRKIRPPSPIPVSSKLSTKTSLSYKITPVQNVLYVPNSLGVIATKKETIQKYPIKKEFGNRSMPSAEAIKKAFIQIRHAAYEQSKNEKERLQKEETKQRIARKPEIMAEKLDKVPAEGSLPCQDEQQDKNPTKTFLESPEVQKAELQKGDSAMMKSRDSAEQRKKEQENILQHWQERLERRKASEISFSSEDEADDEGESEDSLEIFPSGGKMLSMKLKKFHKYAKTKPQKLVFLQSGTDEVDTNKNVYFNGDMKAVKQKDPKYSMIQGKGSKLSAKKPPTRPIRSRKTKEGSTAIRPTQSASSNPNHKWVCDKVIDFNQTPFLKTTLTKSNKESPADSKIACQGPQAHLDHRKRTKSVSVPLTNVLSHLHITGRASNLEHPFASVYSRLAFGKEAEESDV", "length": 876, "header": "sp|A2AEY4-1|MA7D3_MOUSE Isoform 1 of MAP7 domain-containing protein 3 OS=Mus musculus OX=10090 GN=Map7d3 PE=2 SV=1 CANONICAL=A2AEY4-1" }, "isoforms": [ { "isoform_ac": "A0A0R4J1R4-1", "url": "", "sequence": { "sequence": "MADPTFAATSSSTSFRGLHERLVAMTQELAEERRHKRGINSSAGANKRSSSTPDGSVLKNDVKQQLAKERREQQKRQQEANKEKQLLEKEQKAKLQYEKQLEEKHRKLKEQKEKDQRRQASAEEKRKQKQAEDTEKFKAVVSRTLERCNRIDQRQKRWSWEGGVMNADKSGKLENKRSSSLSRKDNRLHPRGDMQHVDNTPAKTPVAAKLEKITTKKLDASLRGHVEGLSMMNIEIPPKITIEVPSPPKLEESSEADAEVRLQTMDDISKVKEDASQKVDIKVPTDENIARHPKPNVEELSPVSVDTSSSVELSSIVSVNSSPSLSTGSFSFGSVEISPVVSIDASLETNIDTSPELSMDSGNTKVASEIKTEAPLQARGESRLEASVEGQPEANVEGSPKNPEIDKRNINLTTKKQPLCHIPCYRWPSSSALGCRPPSPLKALQTRKIRPPSPIPVSSKLSTKTSLSYKITPVQNVLYVPNSLGVIAT", "length": 489, "header": "tr|A0A0R4J1R4-1|MA7D3_MOUSE Computationally mapped isoform of MAP7 domain-containing protein 3 OS=Mus musculus OX=10090 GN=Map7d3 PE=2 SV=1 CANONICAL=A2AEY4-1" }, "locus": { "chromosome": "X", "start_pos": 55867663, "end_pos": 55855015, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000135542.2", "url": "https://www.ensembl.org/id/ENSMUST00000135542.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000115069.2", "url": "https://www.ensembl.org/id/ENSMUSP00000115069.2" } ] } }, { "isoform_ac": "A2AEY4-1", "url": "", "sequence": { "sequence": "MADPTFAATSSSTSFRGLHERLVAMTQELAEERRHKRGINSSAGANKRSSSTPDGSVLKNDVKQQLAKERREQQKRQQEANKEKQLLEKEQKAKLQYEKQLEEKHRKLKEQKEKDQRRQASAEEKRKQKQAEDTEKFKAVVSRTLERCNRIDQRQKRWSWEGGVMNADKSGKLENKRSSSLSRKDNRLHPRGDMQHVDNTPGMTKYVFRYVTAPVFSSDEIKSSAMFCKPSAKTPVAAKLEKITTKKLDASLRGHVEGLSMMNIEIPPKITIEVPSPPKLEESSEADAEVRLQTMDDISKVKEDASQKVDIKVPTDENIARHPKPNVEELSPVSVDTSSSVELSSIVSVNSSPSLSTGSFSFGSVEISPVVSIDASLETNIDTSPELSMDSGNTKVASEIKTEAPLQARGESRLEASVEGQPEANVEGSPKNPEIDKRNINLTTKKQPLCHIPCYRWPSSSALGCRPPSPLKALQTRKIRPPSPIPVSSKLSTKTSLSYKITPVQNVLYVPNSLGVIATKKETIQKYPIKKEFGNRSMPSAEAIKKAFIQIRHAAYEQSKNEKERLQKEETKQRIARKPEIMAEKLDKVPAEGSLPCQDEQQDKNPTKTFLESPEVQKAELQKGDSAMMKSRDSAEQRKKEQENILQHWQERLERRKASEISFSSEDEADDEGESEDSLEIFPSGGKMLSMKLKKFHKYAKTKPQKLVFLQSGTDEVDTNKNVYFNGDMKAVKQKDPKYSMIQGKGSKLSAKKPPTRPIRSRKTKEGSTAIRPTQSASSNPNHKWVCDKVIDFNQTPFLKTTLTKSNKESPADSKIACQGPQAHLDHRKRTKSVSVPLTNVLSHLHITGRASNLEHPFASVYSRLAFGKEAEESDV", "length": 876, "header": "sp|A2AEY4-1|MA7D3_MOUSE Isoform 1 of MAP7 domain-containing protein 3 OS=Mus musculus OX=10090 GN=Map7d3 PE=2 SV=1 CANONICAL=A2AEY4-1" }, "locus": { "chromosome": "X", "start_pos": 55867663, "end_pos": 55843458, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000114766", "url": "https://www.ensembl.org/id/ENSMUST00000114766" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000110414", "url": "https://www.ensembl.org/id/ENSMUSP00000110414" } ] } }, { "isoform_ac": "A2AEY4-2", "url": "", "sequence": { "sequence": "MADPTFAATSSSTSFRGLHERLVAMTQELAEERRHKRGINSSAGANKRSSSTPDGSVLKNDVKQQLAKERREQQKRQQEANKEKQLLEKEQKAKLQYEKQLEEKHRKLKEQKEKDQRRQASAEEKRKQKQAEDTEKFKAVVSRTLERCNRIDQRQKRWSWEGGVMNADKSGKLENKRSSSLSRKDNRLHPRGDMQHVDNTPAKTPVAAKLEKITTKKLDASLRGHVEGLSMMNIEIPPKITIEVPSPPKLEESSEADAEVRLQTMDDISKVKEDASQKVDIKVPTDENIARHPKPNVEELSPVSVDTSSSVELSSIVSVNSSPSLSTGSFSFGSVEISPVVSIDASLETNIDTSPELSMDSGNTKVASEIKTEAPLQARGESRLEASVEGQPEANVEGSPKNPEIDKRNINLTTKKQPLCHIPCYRWPSSSALGCRPPSPLKALQTRKIRPPSPIPVSSKLSTKTSLSYKITPVQNVLYVPNSLGVIATKKETIQKYPIKKEFGNRSMPSAEAIKKAFIQIRHAAYEQSKNEKERLQKEETKQRIARKPEIMAEKLDKVPAEGSLPCQDEQQDKNPTKTFLESPEVQKAELQKGDSAMMKSRDSAEQRKKEQENILQHWQERLERRKASEISFSSEDEADDEGESEDSLEIFPSGGKMLSMKLKKFHKYAKTKPQKLVFLQSGTDEVDTNKNVYFNGDMKAVKQKDPKYSMIQGKGSKLSAKKPPTRPIRSRKTKEGSTAIRPTQSASSNPNHKWVCDKVIDFNQTPFLKTTLTKSNKESPADSKIACQGPQAHLDHRKRTKSVSVPLTNVLSHLHITGRASNLEHPFASVYSRLAFGKEAEESDV", "length": 846, "header": "sp|A2AEY4-2|MA7D3_MOUSE Isoform 2 of MAP7 domain-containing protein 3 OS=Mus musculus OX=10090 GN=Map7d3 PE=2 SV=1 CANONICAL=A2AEY4-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 417, "end_pos": 417, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A2AEY4", "url": "https://www.uniprot.org/uniprot/A2AEY4" } ], "site_lbl": "Ser417" }, { "start_pos": 483, "end_pos": 483, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A2AEY4", "url": "https://www.uniprot.org/uniprot/A2AEY4" } ], "site_lbl": "Ser483" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Mdp3 is a novel microtubule-binding protein that regulates microtubule assembly and stability.", "journal": "Cell Cycle", "date": "2011", "authors": "Sun X, Shi X, Liu M, Li D, Zhang L, Liu X, Zhou J", "evidence": [ { "database": "UniProtKB", "id": "A2AEY4", "url": "https://www.uniprot.org/uniprot/A2AEY4" } ], "reference": [ { "type": "PubMed", "id": "22142902", "url": "https://glygen.org/publication/PubMed/22142902" } ] } ], "pathway": [ { "id": "mmu:320923", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:320923", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "Q8IWC1-1", "protein_name": "MAP7 domain-containing protein 3", "gene_name": "MAP7D3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MMADGAAAGAGGSPSLRELRARMVAAANEIAKERRKQDVVNRVATHSSNIRSTFKPVIDGSMLKNDIKQRLARERREEKRRQQDANKETQLLEKERKTKLQYEKQMEERQRKLKERKEKEEQRRIAAEEKRHQKDEAQKEKFTAILYRTLERRRLADDYQQKRWSWGGSAMANSESKTANKRSASTEKLEQGTSALIRQMPLSSAGLQNSVAKRKTDKERSSSLNRRDSNLHSSTDKEQAERKPRVTGVTNYVMQYVTVPLRKCTSDELRAVMFPMSTMKIPPQTKVEESPLEKVETPPKASVDAPPQVNVEVFCNTSMEASPKAGVGMAPEVSTDSFPVVSVDVSPVVSTYDSEMSMDASPELSIEALPKVDLETVPKVSIVASPEASLEAPPEVSLEALPEVSVEAAPEGSLEAPPKGSAEVAPKESVKGSPKESMEASPEAMVKASPKTSLEASMEASPKAKARDAPKKSEMDKQALIPIAKKRLSSYTECYKWSSSPENACGLPSPISTNRQIQKNCPPSPLPLISKQSPQTSFPYKIMPIQHTLSVQSASSTVKKKKETVSKTTNRCEALSQRHMIYEESGNKSTAGIMNAEAATKILTELRRLAREQREKEEEERQREEMQQRVIKKSKDMAKEAVGGQAEDHLKLKDGQQQNETKKKKGWLDQEDQEAPLQKGDAKIKAQEEADKRKKEHERIMLQNLQERLERKKRIEEIMKRTRKTDVNASKVTETSSHDIYEEAEADNEESDKDSLNEMFPSAILNGTGSPTKFKMPFNNAKKMTHKLVFLEDGTSQVRKEPKTYFNGDLKNFRQKSMKDTSIQEVVSRPSSKRMTSHTTKTRKADETNTTSRSSAQTKSEGFHDILPKSSDTFRQ", "length": 876 }, "evidence": [ { "id": "A2AEY4", "url": "https://omabrowser.org/oma/group/A2AEY4/", "database": "OMA" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "microtubule polymerization", "id": "GO:0046785", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046785", "evidence": [ { "database": "UniProtKB", "id": "A2AEY4", "url": "https://www.uniprot.org/uniprot/A2AEY4" } ], "pmid": "" }, { "name": "microtubule cytoskeleton organization", "id": "GO:0000226", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000226", "evidence": [ { "database": "UniProtKB", "id": "A2AEY4", "url": "https://www.uniprot.org/uniprot/A2AEY4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A2AEY4", "url": "https://www.uniprot.org/uniprot/A2AEY4" } ], "pmid": "" }, { "name": "spindle", "id": "GO:0005819", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005819", "evidence": [ { "database": "UniProtKB", "id": "A2AEY4", "url": "https://www.uniprot.org/uniprot/A2AEY4" } ], "pmid": "" }, { "name": "microtubule cytoskeleton", "id": "GO:0015630", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015630", "evidence": [ { "database": "UniProtKB", "id": "A2AEY4", "url": "https://www.uniprot.org/uniprot/A2AEY4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "microtubule binding", "id": "GO:0008017", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008017", "evidence": [ { "database": "UniProtKB", "id": "A2AEY4", "url": "https://www.uniprot.org/uniprot/A2AEY4" } ], "pmid": "" }, { "name": "tubulin binding", "id": "GO:0015631", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015631", "evidence": [ { "database": "UniProtKB", "id": "A2AEY4", "url": "https://www.uniprot.org/uniprot/A2AEY4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 350, "end_pos": 352, "annotation": "n_glycosylation_sequon" }, { "start_pos": 40, "end_pos": 42, "annotation": "n_glycosylation_sequon" }, { "start_pos": 441, "end_pos": 443, "annotation": "n_glycosylation_sequon" }, { "start_pos": 535, "end_pos": 537, "annotation": "n_glycosylation_sequon" }, { "start_pos": 794, "end_pos": 796, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }