{
    "uniprot_canonical_ac": "A2AAX3-1",
    "uniprot_ac": "A2AAX3",
    "uniprot_id": "KLH15_MOUSE",
    "mass": {
        "chemical_mass": 69745.0,
        "monoisotopic_mass": 69745.0
    },
    "refseq": {
        "ac": "XP_006528049",
        "name": "kelch-like protein 15 isoform X1",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006528049"
    },
    "gene_names": [
        {
            "name": "Klhl15",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/A2AAX3",
            "id": "A2AAX3"
        },
        {
            "name": "6330500C13Rik",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006528049",
            "id": "XP_006528049"
        },
        {
            "name": "Klhl15",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006528049",
            "id": "XP_006528049"
        }
    ],
    "protein_names": [
        {
            "name": "Kelch-like protein 15",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "",
            "id": "A2AAX3"
        },
        {
            "name": "kelch-like protein 15 isoform X1",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006528049",
            "id": "XP_006528049"
        }
    ],
    "function": [
        {
            "annotation": "Substrate-specific adapter for CUL3 E3 ubiquitin-protein ligase complex. Acts as an adapter for CUL3 to target the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits and regulating PP2A holoenzyme composition. Acts as an adapter for CUL3 to target the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. Through the regulation of RBBP8/CtIP protein turnover, plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR).",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2AAX3",
                    "url": "https://www.uniprot.org/uniprot/A2AAX3#function"
                },
                {
                    "database": "UniProtKB",
                    "id": "Q96M94",
                    "url": "https://www.uniprot.org/uniprot/Q96M94#function"
                }
            ]
        }
    ],
    "disease": [
        {
            "disease_id": "DOID:0112020",
            "recommended_name": {
                "id": "DOID:0112020",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:0112020",
                "name": "non-syndromic X-linked intellectual disability 103",
                "description": "A non-syndromic X-linked intellectual disability characterized by intellectual disability and facial feature anomalies that has_material_basis_in hemizygous mutation in the KLHL15 gene on chromosome Xp22.11."
            },
            "synonyms": [
                {
                    "id": "DOID:0112020",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0112020",
                    "name": "MRX103",
                    "description": ""
                },
                {
                    "id": "DOID:0112020",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0112020",
                    "name": "X-linked mental retardation 103",
                    "description": ""
                },
                {
                    "id": "MONDO:0010508",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010508",
                    "name": "intellectual disability, X-linked 103",
                    "description": "Any non-syndromic X-linked intellectual disability in which the cause of the disease is a mutation in the KLHL15 gene."
                },
                {
                    "id": "MONDO:0010508",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010508",
                    "name": "KLHL15 non-syndromic X-linked intellectual disability",
                    "description": ""
                },
                {
                    "id": "MONDO:0010508",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010508",
                    "name": "MRX103",
                    "description": ""
                },
                {
                    "id": "MONDO:0010508",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010508",
                    "name": "intellectual developmental disorder, X-linked 103, X-linked recessive",
                    "description": ""
                },
                {
                    "id": "MONDO:0010508",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010508",
                    "name": "intellectual disability, X-linked 103",
                    "description": ""
                },
                {
                    "id": "MONDO:0010508",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010508",
                    "name": "intellectual disability, X-linked type 103",
                    "description": ""
                },
                {
                    "id": "MONDO:0010508",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010508",
                    "name": "mental retardation, X-linked 103",
                    "description": ""
                },
                {
                    "id": "MONDO:0010508",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010508",
                    "name": "mental retardation, X-linked type 103",
                    "description": ""
                },
                {
                    "id": "MONDO:0010508",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010508",
                    "name": "non-syndromic X-linked intellectual disability caused by mutation in KLHL15",
                    "description": ""
                },
                {
                    "id": "MIM:300982",
                    "resource": "MIM",
                    "url": "https://www.omim.org/entry/300982",
                    "name": "Intellectual developmental disorder, X-linked 103",
                    "description": "Intellectual developmental disorder, X-linked 103"
                }
            ],
            "evidence": [
                {
                    "id": "0112020",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:0112020"
                }
            ]
        }
    ],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Mus musculus",
            "taxid": 10090,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2AAX3",
                    "url": "https://www.uniprot.org/uniprot/A2AAX3"
                }
            ],
            "common_name": "Mouse"
        }
    ],
    "gene": [
        {
            "name": "Klhl15",
            "url": "https://www.uniprot.org/uniprot/A2AAX3",
            "locus": {
                "chromosome": "X",
                "start_pos": 93321330,
                "end_pos": 93278205,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSMUSG00000043929",
                        "url": "https://www.ensembl.org/id/ENSMUSG00000043929"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSMUSG00000043929",
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000043929",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "cd18244",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18244",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "cd18454",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18454",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "236904",
            "url": "https://www.ncbi.nlm.nih.gov/gene/236904",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "IPR000210",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR000210",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR006652",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR006652",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR011333",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR011333",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR011705",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR011705",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR015915",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR015915",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR017096",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR017096",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR030597",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR030597",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR047030",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR047030",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "mmu:236904",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:236904",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "1923400",
            "url": "http://www.informatics.jax.org/marker/MGI:1923400",
            "database": "MGI",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "ADQWTIL",
            "url": "https://omabrowser.org/oma/group/ADQWTIL/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "5472491at2759",
            "url": "http://www.orthodb.org/?query=5472491at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR45632",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45632",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR45632:SF12",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45632:SF12",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF00651",
            "url": "http://pfam.xfam.org/family/PF00651",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF01344",
            "url": "http://pfam.xfam.org/family/PF01344",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF07707",
            "url": "http://pfam.xfam.org/family/PF07707",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PR_A2AAX3",
            "url": "http://purl.obolibrary.org/obo/PR_A2AAX3",
            "database": "PRO",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "XP_006528049",
            "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006528049",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A2AAX0",
            "url": "https://www.uniprot.org/uniprot/A2AAX0",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A2AAX0-1",
            "url": "https://www.uniprot.org/uniprot/A2AAX0-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A2AAX3",
            "url": "https://www.uniprot.org/uniprot/A2AAX3",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A2AAX3-1",
            "url": "https://www.uniprot.org/uniprot/A2AAX3-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A2AAX3-2",
            "url": "https://www.uniprot.org/uniprot/A2AAX3-2",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A2AAX3-3",
            "url": "https://www.uniprot.org/uniprot/A2AAX3-3",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MAGDVEGFCSSIHDTSVSAGFRALYEEGLLLDVTLVIEDHQFQAHKALLATQSDYFRIMFTADMRERDQDKIHLKGLTATGFSHVLQFMYYGTIELSMNTVHEILQAAMYVQLIEVVKFCCSFLLAKICLENCAEIMRLLDDFGVNIEGVREKLDAFLLDNFVPLMSRPDFLSYLSFEKLMSYLDNDHLSRFPEIELYEAVQSWLRHDRRRWRHTDTIIQNIRFCLMTPSSVFEKVKTSEFYRYSRQLRYEVDQALNYFQNVHQQPLLDMKSSRIRSAKPQTTVFRGMIGHSMVNSKILLLKKPRVWWELEGPQVPLRPDCLAIVNNFVFLLGGEELGPDGEFHASSKVFRYDPRQNSWLRMADMSVPRSEFAVGVIGKFIYAVAGRTRDETFYSTERYDITNDKWEFVDPYPVNKYGHEGTVLNNKLFITGGITSSSTSKQVCVFDPSKEGTIEQRTRRTQVVTNCWENKSKMNYARCFHKMISYNGKLYVFGGVCVILRASFESQGCPSTEVYNPDTDQWTILASMPIGRSGHGVTVLDKQIMVLGGLCYNGHYSDSILTFDPDENKWKEDEYPRMPCKLDGLQVCNLHFPDYVLDEVRRCN",
        "length": 604,
        "header": "sp|A2AAX3-1|KLH15_MOUSE Isoform 1 of Kelch-like protein 15  OS=Mus musculus OX=10090 GN=Klhl15 PE=2 SV=1 CANONICAL=A2AAX3-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A2AAX0-1",
            "url": "",
            "sequence": {
                "sequence": "MAGDVEGFCSSIHDTSVSAGFRALYEEGLLLDVTLVIEDHQFQAHKALLATQSDYFRIMFTADMRERDQDKIHLKGLTATGFSHVLQFMYYGTIELSMNTVHEILQ",
                "length": 106,
                "header": "tr|A2AAX0-1|A2AAX0_MOUSE Computationally mapped isoform of Kelch-like 15  OS=Mus musculus OX=10090 GN=Klhl15 PE=1 SV=1 CANONICAL=A2AAX3-1"
            },
            "locus": {
                "chromosome": "X",
                "start_pos": 93296345,
                "end_pos": 93296028,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000153900.8",
                        "url": "https://www.ensembl.org/id/ENSMUST00000153900.8"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000120863.2",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000120863.2"
                    }
                ]
            }
        },
        {
            "isoform_ac": "A2AAX3-1",
            "url": "",
            "sequence": {
                "sequence": "MAGDVEGFCSSIHDTSVSAGFRALYEEGLLLDVTLVIEDHQFQAHKALLATQSDYFRIMFTADMRERDQDKIHLKGLTATGFSHVLQFMYYGTIELSMNTVHEILQAAMYVQLIEVVKFCCSFLLAKICLENCAEIMRLLDDFGVNIEGVREKLDAFLLDNFVPLMSRPDFLSYLSFEKLMSYLDNDHLSRFPEIELYEAVQSWLRHDRRRWRHTDTIIQNIRFCLMTPSSVFEKVKTSEFYRYSRQLRYEVDQALNYFQNVHQQPLLDMKSSRIRSAKPQTTVFRGMIGHSMVNSKILLLKKPRVWWELEGPQVPLRPDCLAIVNNFVFLLGGEELGPDGEFHASSKVFRYDPRQNSWLRMADMSVPRSEFAVGVIGKFIYAVAGRTRDETFYSTERYDITNDKWEFVDPYPVNKYGHEGTVLNNKLFITGGITSSSTSKQVCVFDPSKEGTIEQRTRRTQVVTNCWENKSKMNYARCFHKMISYNGKLYVFGGVCVILRASFESQGCPSTEVYNPDTDQWTILASMPIGRSGHGVTVLDKQIMVLGGLCYNGHYSDSILTFDPDENKWKEDEYPRMPCKLDGLQVCNLHFPDYVLDEVRRCN",
                "length": 604,
                "header": "sp|A2AAX3-1|KLH15_MOUSE Isoform 1 of Kelch-like protein 15  OS=Mus musculus OX=10090 GN=Klhl15 PE=2 SV=1 CANONICAL=A2AAX3-1"
            },
            "locus": {
                "chromosome": "X",
                "start_pos": 93317068,
                "end_pos": 93296028,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000113915",
                        "url": "https://www.ensembl.org/id/ENSMUST00000113915"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000109548",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000109548"
                    }
                ]
            }
        },
        {
            "isoform_ac": "A2AAX3-2",
            "url": "",
            "sequence": {
                "sequence": "MAGDVEGFCSSIHDTSVSAGFRALYEEGLLLDVTLVIEDHQFQAHKALLATQSDYFRIMFTADMRERDQDKIHLKGLTATGFSHVLQFMYYGTIELSMNTVHEILQAAMYVQLIEVVKFCCSFLLAKICLENCAEIMRLLDDFGVNIEGVREKLDAFLLDNFVPLMSRPDFLSYLSFEKLMSYLDNDHLSRFPEIELYEAVQSWLRHDRRRWRHTDTIIQNIRFCLMTPSSVFEKVGTFESDRQDSSI",
                "length": 248,
                "header": "sp|A2AAX3-2|KLH15_MOUSE Isoform 2 of Kelch-like protein 15  OS=Mus musculus OX=10090 GN=Klhl15 PE=2 SV=1 CANONICAL=A2AAX3-1"
            },
            "locus": {
                "chromosome": "X",
                "start_pos": 93296771,
                "end_pos": 93296028,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000096369",
                        "url": "https://www.ensembl.org/id/ENSMUST00000096369"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000094097",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000094097"
                    }
                ]
            }
        },
        {
            "isoform_ac": "A2AAX3-3",
            "url": "",
            "sequence": {
                "sequence": "MAGDVEGFCSSIHDTSVSAGFRALYEEGLLLDVTLVIEDHQFQAHKALLATQSDYFRIMFTADMRERDQDKIHLKGLTATGFSHVLQFMYYGTIELSMNTVHEILQAAMYVQLIEVVKFCCSFLLAKICLENCAEIMRLLDDFGVNIEGVREKLDAFLLDNFVPLMSRPDFLSYLSFEKLMSYLDNDHLSRFPEIELYEAVQSWLRHDRRRWRHTDTIIQNIRFCLMTPSSVFEKTS",
                "length": 237,
                "header": "sp|A2AAX3-3|KLH15_MOUSE Isoform 3 of Kelch-like protein 15  OS=Mus musculus OX=10090 GN=Klhl15 PE=2 SV=1 CANONICAL=A2AAX3-1"
            },
            "locus": {
                "chromosome": "X",
                "start_pos": 93297551,
                "end_pos": 93296028,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000113908",
                        "url": "https://www.ensembl.org/id/ENSMUST00000113908"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000109541",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000109541"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [],
    "publication": [],
    "pathway": [
        {
            "id": "mmu:236904",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:236904",
            "resource": "KEGG Pathway"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "D3ZA50-1",
            "protein_name": "Kelch-like protein 15",
            "gene_name": "Klhl15",
            "tax_id": 10116,
            "organism": "Rattus norvegicus",
            "sequence": {
                "sequence": "MAGDVEGFCSSIHDTSVSAGFRALYEEGLLLDVTLVIEDHQFQAHKALLATQSDYFRIMFTADMRERDQDKIHLKGLTATGFSHVLQFMYYGTIELSMNTVHEILQAAMYVQLIEVVKFCCSFLLAKICLENCAEIMRLLDDFGVNIEGVREKLDAFLLDNFVPLMSRPDFLSYLSFEKLMSYLDNDHLSRFPEIELYEAVQSWLRHDRRRWRHTDTIIQNIRFCLMTPSSVFEKVKTSEFYRYSRQLRYEVDQALNYFQNVHQQPLLDMKSSRIRSAKPQTTVFRGMIGHSMVNSKILLLKKPRVWWELEGPQVPLRPDCLAIVNNFVFLLGGEELGPDGEFHASSKVFRYDPRQNSWLRMADMSVPRSEFAVGVIGKFIYAVAGRTRDETFYSTERYDITNDKWEFVDPYPVNKYGHEGTVLNNKLFITGGITSSSTSKQVCVFDPSKEGTIEQRTRRTQVVTNCWENKSKMNYARCFHKMISYNGKLYVFGGVCVILRASFESQGCPSTEVYNPDTDQWTILASMPIGRSGHGVTVLDKQIMVLGGLCYNGHYSDSILTFDPDENKWKEDEYPRMPCKLDGLQVCNLHFPDYVLDEVRRCN",
                "length": 604
            },
            "evidence": [
                {
                    "id": "45233057",
                    "url": "http://www.informatics.jax.org/homology/45233057",
                    "database": "MGI"
                },
                {
                    "id": "A2AAX3",
                    "url": "https://omabrowser.org/oma/group/A2AAX3/",
                    "database": "OMA"
                }
            ],
            "common_name": "Rat"
        },
        {
            "uniprot_canonical_ac": "Q96M94-1",
            "protein_name": "Kelch-like protein 15",
            "gene_name": "KLHL15",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MAGDVEGFCSSIHDTSVSAGFRALYEEGLLLDVTLVIEDHQFQAHKALLATQSDYFRIMFTADMRERDQDKIHLKGLTATGFSHVLQFMYYGTIELSMNTVHEILQAAMYVQLIEVVKFCCSFLLAKICLENCAEIMRLLDDFGVNIEGVREKLDTFLLDNFVPLMSRPDFLSYLSFEKLMSYLDNDHLSRFPEIELYEAVQSWLRHDRRRWRHTDTIIQNIRFCLMTPTSVFEKVKTSEFYRYSRQLRYEVDQALNYFQNVHQQPLLDMKSSRIRSAKPQTTVFRGMIGHSMVNSKILLLKKPRVWWELEGPQVPLRPDCLAIVNNFVFLLGGEELGPDGEFHASSKVFRYDPRQNSWLQMADMSVPRSEFAVGVIGKFIYAVAGRTRDETFYSTERYDITNDKWEFVDPYPVNKYGHEGTVLNNKLFITGGITSSSTSKQVCVFDPSKEGTIEQRTRRTQVVTNCWENKSKMNYARCFHKMISYNGKLYVFGGVCVILRASFESQGCPSTEVYNPETDQWTILASMPIGRSGHGVTVLDKQIMVLGGLCYNGHYSDSILTFDPDENKWKEDEYPRMPCKLDGLQVCNLHFPDYVLDEVRRCN",
                "length": 604
            },
            "evidence": [
                {
                    "id": "45233057",
                    "url": "http://www.informatics.jax.org/homology/45233057",
                    "database": "MGI"
                },
                {
                    "id": "A2AAX3",
                    "url": "https://omabrowser.org/oma/group/A2AAX3/",
                    "database": "OMA"
                }
            ],
            "common_name": "Human"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Biological Process",
                "total": 4,
                "go_terms": [
                    {
                        "name": "protein ubiquitination",
                        "id": "GO:0016567",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016567",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AAX3",
                                "url": "https://www.uniprot.org/uniprot/A2AAX3"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "negative regulation of double-strand break repair via homologous recombination",
                        "id": "GO:2000042",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000042",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AAX3",
                                "url": "https://www.uniprot.org/uniprot/A2AAX3"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "ubiquitin-dependent protein catabolic process",
                        "id": "GO:0006511",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006511",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AAX3",
                                "url": "https://www.uniprot.org/uniprot/A2AAX3"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "nuclear protein quality control by the ubiquitin-proteasome system",
                        "id": "GO:0071630",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071630",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AAX3",
                                "url": "https://www.uniprot.org/uniprot/A2AAX3"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Cellular Component",
                "total": 2,
                "go_terms": [
                    {
                        "name": "nucleus",
                        "id": "GO:0005634",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AAX3",
                                "url": "https://www.uniprot.org/uniprot/A2AAX3"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "Cul3-RING ubiquitin ligase complex",
                        "id": "GO:0031463",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031463",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AAX3",
                                "url": "https://www.uniprot.org/uniprot/A2AAX3"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Molecular Function",
                "total": 1,
                "go_terms": [
                    {
                        "name": "ubiquitin ligase-substrate adaptor activity",
                        "id": "GO:1990756",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990756",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AAX3",
                                "url": "https://www.uniprot.org/uniprot/A2AAX3"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            }
        ]
    },
    "pro_annotation": [],
    "site_annotation": [
        {
            "start_pos": 470,
            "end_pos": 472,
            "annotation": "n_glycosylation_sequon"
        }
    ],
    "ptm_annotation": [],
    "interactions": [],
    "reactions": [],
    "reaction_participants": [],
    "reaction_enzymes": [],
    "biomarkers": [],
    "synthesized_glycans": [],
    "cluster_types": [
        {
            "name": "isoformset.uniprotkb",
            "label": "Isoforms"
        },
        {
            "name": "homologset.mgi",
            "label": "MGI Homologs"
        },
        {
            "name": "homologset.oma",
            "label": "OMA Homologs"
        }
    ],
    "section_stats": [
        {
            "table_id": "glycosylation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_reported",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
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                },
                {
                    "field": "n_linked_glycans",
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                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_reported_with_glycan",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
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                {
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                {
                    "field": "n_linked_glycan_sites",
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                {
                    "field": "o_linked_glycans",
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                {
                    "field": "o_linked_glycan_sites",
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                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_predicted",
            "table_stats": [
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                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
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                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
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                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
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                {
                    "field": "o_linked_glycans",
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                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_automatic_literature_mining",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "phosphorylation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "snv",
            "table_stats": [
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                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
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                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "snv_disease",
            "table_stats": [
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                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
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            ],
            "sort_fields": []
        },
        {
            "table_id": "snv_non_disease",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
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                {
                    "field": "total_sites",
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            ],
            "sort_fields": []
        },
        {
            "table_id": "publication",
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                    "field": "total",
                    "count": 0
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            "sort_fields": []
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    ]
}