{
    "uniprot_canonical_ac": "A2A6Q5-1",
    "uniprot_ac": "A2A6Q5",
    "uniprot_id": "CDC27_MOUSE",
    "mass": {
        "chemical_mass": 91842.0,
        "monoisotopic_mass": 91842.0
    },
    "refseq": {
        "ac": "NP_001272917",
        "name": "cell division cycle protein 27 homolog isoform 1",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001272917"
    },
    "gene_names": [
        {
            "name": "Cdc27",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/A2A6Q5",
            "id": "A2A6Q5"
        },
        {
            "name": "APC3",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001272917",
            "id": "NP_001272917"
        },
        {
            "name": "Cdc27",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001272917",
            "id": "NP_001272917"
        }
    ],
    "protein_names": [
        {
            "name": "Cell division cycle protein 27 homolog",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "",
            "id": "A2A6Q5"
        },
        {
            "name": "Cell division cycle protein 27 homolog; cell division cycle 27 homolog",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001272917",
            "id": "NP_001272917"
        },
        {
            "name": "cell division cycle protein 27 homolog isoform 1",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001272917",
            "id": "NP_001272917"
        }
    ],
    "function": [
        {
            "annotation": "Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity).",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2A6Q5",
                    "url": "https://www.uniprot.org/uniprot/A2A6Q5#function"
                }
            ]
        }
    ],
    "disease": [],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Mus musculus",
            "taxid": 10090,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2A6Q5",
                    "url": "https://www.uniprot.org/uniprot/A2A6Q5"
                }
            ],
            "common_name": "Mouse"
        }
    ],
    "gene": [
        {
            "name": "Cdc27",
            "url": "https://www.uniprot.org/uniprot/A2A6Q5",
            "locus": {
                "chromosome": "11",
                "start_pos": 104393571,
                "end_pos": 104441446,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSMUSG00000020687",
                        "url": "https://www.ensembl.org/id/ENSMUSG00000020687"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSMUSG00000020687",
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000020687",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "217232",
            "url": "https://www.ncbi.nlm.nih.gov/gene/217232",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "A2A6Q5",
            "url": "https://www.ebi.ac.uk/intact/interactors/id:A2A6Q5*",
            "database": "IntAct",
            "categories": [
                "Other"
            ]
        },
        {
            "id": "IPR001440",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001440",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR011990",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR011990",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR019734",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR019734",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "mmu:217232",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:217232",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "102685",
            "url": "http://www.informatics.jax.org/marker/MGI:102685",
            "database": "MGI",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "LMAQICV",
            "url": "https://omabrowser.org/oma/group/LMAQICV/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "152021at2759",
            "url": "http://www.orthodb.org/?query=152021at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR12558",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12558",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR12558:SF13",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12558:SF13",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF00515",
            "url": "http://pfam.xfam.org/family/PF00515",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF12895",
            "url": "http://pfam.xfam.org/family/PF12895",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF13181",
            "url": "http://pfam.xfam.org/family/PF13181",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PR_A2A6Q5",
            "url": "http://purl.obolibrary.org/obo/PR_A2A6Q5",
            "database": "PRO",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "R-MMU-141430",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-141430",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-MMU-174048",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-174048",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-MMU-174084",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-174084",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-MMU-174154",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-174154",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-MMU-174178",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-174178",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-MMU-174184",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-174184",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-MMU-176407",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-176407",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-MMU-176408",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-176408",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-MMU-176409",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-176409",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-MMU-176412",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-176412",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-MMU-179409",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-179409",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-MMU-2467813",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2467813",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-MMU-2559582",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2559582",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-MMU-68867",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-68867",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-MMU-69017",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-69017",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-MMU-983168",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-983168",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "NP_001272917",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001272917",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A2A6Q5",
            "url": "https://www.uniprot.org/uniprot/A2A6Q5",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A2A6Q5-1",
            "url": "https://www.uniprot.org/uniprot/A2A6Q5-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A2A6Q5-2",
            "url": "https://www.uniprot.org/uniprot/A2A6Q5-2",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A2A6Q5-3",
            "url": "https://www.uniprot.org/uniprot/A2A6Q5-3",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q8R568",
            "url": "https://www.uniprot.org/uniprot/Q8R568",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q8R568-1",
            "url": "https://www.uniprot.org/uniprot/Q8R568-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MTVLQEPVQAAIWQALNHYAYRDAVFLAERLYAEVHSEEALFLLATCYYRSGKAYKAYRLLKGHSCTTPQCKYLLAKCCVDLSKLAEGEQILSGGVFNKQKSHDDLVTEFGDSACFTLSLLGHVYCKTDRLAKGSECYQKSLSLNPFLWSPFESLCEIGEKPDPDQTFKLTSLQNFSSCLPNTCTTLVSNHSLSHRQPETVLTETPQDTIELNRLNLESSNSKYSLNTDSSVSYIDSTVISPDNVPLGPGTAILSKQVQNKPKTGRSLLGGPTALSPLTPSFGILPLETPSPGDGSYLQNYTNTPSVIDVAPTGAPTKKSVARMGQTGTKSVFSQSGNSREVTPVLVAQTQSSGPQTSTTPQVLSPTITSPPNALPRRSSRLFTSDSSTTKENSKKLKMKFPPKIPNRKTKSKTNKGGLTQPSINDSLEITKLDSSIISEGKITTVTPQIQAFNLQKAAAEGLMSLLREMGKGYLALCSYNCKEAINILSHLPSHHYSTGWVLCQIGRAYFELSEYMQAERIFSEVRRIESFRVEGMEIYSTTLWHLQKDVALSVLSKDLTDMDKNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTLLGHEFVLTEELDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINPQSSVLLCHIGVVQHALKKSEKALDTLNKAIVIDPKNPLCKFHRASVLFANEKYKSALQELEELKQIVPKESLVYFLIGKVYKKLGQTHLALMNFSWAMDLDPKGANNQIKEAIDKRYLPDDEEPITQEEQIMGTDESQESSMTDADDTQLHAAESDEF",
        "length": 825,
        "header": "sp|A2A6Q5-1|CDC27_MOUSE Isoform 1 of Cell division cycle protein 27 homolog  OS=Mus musculus OX=10090 GN=Cdc27 PE=1 SV=1 CANONICAL=A2A6Q5-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A2A6Q5-1",
            "url": "",
            "sequence": {
                "sequence": "MTVLQEPVQAAIWQALNHYAYRDAVFLAERLYAEVHSEEALFLLATCYYRSGKAYKAYRLLKGHSCTTPQCKYLLAKCCVDLSKLAEGEQILSGGVFNKQKSHDDLVTEFGDSACFTLSLLGHVYCKTDRLAKGSECYQKSLSLNPFLWSPFESLCEIGEKPDPDQTFKLTSLQNFSSCLPNTCTTLVSNHSLSHRQPETVLTETPQDTIELNRLNLESSNSKYSLNTDSSVSYIDSTVISPDNVPLGPGTAILSKQVQNKPKTGRSLLGGPTALSPLTPSFGILPLETPSPGDGSYLQNYTNTPSVIDVAPTGAPTKKSVARMGQTGTKSVFSQSGNSREVTPVLVAQTQSSGPQTSTTPQVLSPTITSPPNALPRRSSRLFTSDSSTTKENSKKLKMKFPPKIPNRKTKSKTNKGGLTQPSINDSLEITKLDSSIISEGKITTVTPQIQAFNLQKAAAEGLMSLLREMGKGYLALCSYNCKEAINILSHLPSHHYSTGWVLCQIGRAYFELSEYMQAERIFSEVRRIESFRVEGMEIYSTTLWHLQKDVALSVLSKDLTDMDKNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTLLGHEFVLTEELDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINPQSSVLLCHIGVVQHALKKSEKALDTLNKAIVIDPKNPLCKFHRASVLFANEKYKSALQELEELKQIVPKESLVYFLIGKVYKKLGQTHLALMNFSWAMDLDPKGANNQIKEAIDKRYLPDDEEPITQEEQIMGTDESQESSMTDADDTQLHAAESDEF",
                "length": 825,
                "header": "sp|A2A6Q5-1|CDC27_MOUSE Isoform 1 of Cell division cycle protein 27 homolog  OS=Mus musculus OX=10090 GN=Cdc27 PE=1 SV=1 CANONICAL=A2A6Q5-1"
            },
            "locus": {
                "chromosome": "11",
                "start_pos": 104441215,
                "end_pos": 104396427,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000093923",
                        "url": "https://www.ensembl.org/id/ENSMUST00000093923"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000091452",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000091452"
                    }
                ]
            }
        },
        {
            "isoform_ac": "A2A6Q5-2",
            "url": "",
            "sequence": {
                "sequence": "MTVLQEPVQAAIWQALNHYAYRDAVFLAERLYAEVHSEEALFLLATCYYRSGKAYKAYRLLKGHSCTTPQCKYLLAKCCVDLSKLAEGEQILSGGVFNKQKSHDDLVTEFGDSACFTLSLLGHVYCKTDRLAKGSECYQKSLSLNPFLWSPFESLCEIGEKPDPDQTFKLTSLQNFSSCLPNTCTTLVSNHSLSHRQPETVLTETPQDTIELNRLNLESSNSKYSLNTDSSVSYIDSTVISPDNVPLGPGTAILSKQVQNKPKTGRSLLGGPTALSPLTPSFGILPLETPSPGDGSYLQNYTNTPSVIDVAPTGAPTKKTFCVLQSVARMGQTGTKSVFSQSGNSREVTPVLVAQTQSSGPQTSTTPQVLSPTITSPPNALPRRSSRLFTSDSSTTKENSKKLKMKFPPKIPNRKTKSKTNKGGLTQPSINDSLEITKLDSSIISEGKITTVTPQIQAFNLQKAAAGLMSLLREMGKGYLALCSYNCKEAINILSHLPSHHYSTGWVLCQIGRAYFELSEYMQAERIFSEVRRIESFRVEGMEIYSTTLWHLQKDVALSVLSKDLTDMDKNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTLLGHEFVLTEELDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINPQSSVLLCHIGVVQHALKKSEKALDTLNKAIVIDPKNPLCKFHRASVLFANEKYKSALQELEELKQIVPKESLVYFLIGKVYKKLGQTHLALMNFSWAMDLDPKGANNQIKEAIDKRYLPDDEEPITQEEQIMGTDESQESSMTDADDTQLHAAESDEF",
                "length": 830,
                "header": "sp|A2A6Q5-2|CDC27_MOUSE Isoform 2 of Cell division cycle protein 27 homolog  OS=Mus musculus OX=10090 GN=Cdc27 PE=1 SV=1 CANONICAL=A2A6Q5-1"
            },
            "locus": {}
        },
        {
            "isoform_ac": "A2A6Q5-3",
            "url": "",
            "sequence": {
                "sequence": "MTVLQEPVQAAIWQALNHYAYRDAVFLAERLYAEVHSEEALFLLATCYYRSGKAYKAYRLLKGHSCTTPQCKYLLAKCCVDLSKLAEGEQILSGGVFNKQKSHDDLVTEFGDSACFTLSLLGHVYCKTDRLAKGSECYQKSLSLNPFLWSPFESLCEIGEKPDPDQTFKLTSLQNFSSCLPNTCTTLVSNHSLSHRQPETVLTETPQDTIELNRLNLESSNSKYSLNTDSSVSYIDSTVISPDNVPLGPGTAILSKQVQNKPKTGRSLLGGPTALSPLTPSFGILPLETPSPGDGSYLQNYTNTPSVIDVAPTGAPTKKTFCVLQSVARMGQTGTKSVFSQSGNSREVTPVLVAQTQSSGPQTSTTPQVLSPTITSPPNALPRRSSRLFTSDSSTTKENSKKLKMKFPPKIPNRKTKSKTNKGGLTQPSINDSLEITKLDSSIISEGKITTVTPQIQAFNLQKAAAEGLMSLLREMGKGYLALCSYNCKEAINILSHLPSHHYSTGWVLCQIGRAYFELSEYMQAERIFSEVRRIESFRVEGMEIYSTTLWHLQKDVALSVLSKDLTDMDKNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTLLGHEFVLTEELDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINPQSSVLLCHIGVVQHALKKSEKALDTLNKAIVIDPKNPLCKFHRASVLFANEKYKSALQELEELKQIVPKESLVYFLIGKVYKKLGQTHLALMNFSWAMDLDPKGANNQIKEAIDKRYLPDDEEPITQEEQIMGTDESQESSMTDADDTQLHAAESDEF",
                "length": 831,
                "header": "sp|A2A6Q5-3|CDC27_MOUSE Isoform 3 of Cell division cycle protein 27 homolog  OS=Mus musculus OX=10090 GN=Cdc27 PE=1 SV=1 CANONICAL=A2A6Q5-1"
            },
            "locus": {
                "chromosome": "11",
                "start_pos": 104441215,
                "end_pos": 104396427,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000106962",
                        "url": "https://www.ensembl.org/id/ENSMUST00000106962"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000102575",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000102575"
                    }
                ]
            }
        },
        {
            "isoform_ac": "Q8R568-1",
            "url": "",
            "sequence": {
                "sequence": "MTVLQEPVQAAIWQALNHYAYRDAVFLAERLYAEVHSEEALFLLATCYYRSGKAYKAYRLLKGHSCTTPQCKYLLAKCCVDLSKLAEGEQILSGGVFNKQKSHDDLVTEFGDSACFTLSLLGHVYCKTDRLAKGSECYQKSLSLNPFLWSPFESLCEIGEKPDPDQTFKLTSLQNFSSCLPNTCTTLVSNHSLSHRQPETVLTETPQDTIELNRLNLESSNSKYSLNTDSSVSYIDSTVISPDNVPLGPGTAILSKQVQNKPKTGRSLLGGPTALSPLTPSFGILPLETPSPGDGSYLQNYTNTPSVIDVAPTGAPTKKTFCVLQSVARMGQTGTKSVFSQSGNSREVTPVLVAQTQSSGPQTSTTPQVLSPTITSPPNALPRRSSRLFTSDSSTTKKV",
                "length": 399,
                "header": "tr|Q8R568-1|Q8R568_MOUSE Computationally mapped isoform of Cell division cycle 27 homolog (S. cerevisiae)  OS=Mus musculus OX=10090 GN=Cdc27 PE=1 SV=1 CANONICAL=A2A6Q5-1"
            },
            "locus": {
                "chromosome": "11",
                "start_pos": 104441215,
                "end_pos": 104411657,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000106961.2",
                        "url": "https://www.ensembl.org/id/ENSMUST00000106961.2"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000102574.2",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000102574.2"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [
        {
            "start_pos": 205,
            "end_pos": 205,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Thr",
            "comment": "Phosphothreonine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2A6Q5",
                    "url": "https://www.uniprot.org/uniprot/A2A6Q5"
                }
            ],
            "site_lbl": "Thr205"
        },
        {
            "start_pos": 209,
            "end_pos": 209,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Thr",
            "comment": "Phosphothreonine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2A6Q5",
                    "url": "https://www.uniprot.org/uniprot/A2A6Q5"
                }
            ],
            "site_lbl": "Thr209"
        },
        {
            "start_pos": 291,
            "end_pos": 291,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2A6Q5",
                    "url": "https://www.uniprot.org/uniprot/A2A6Q5"
                }
            ],
            "site_lbl": "Ser291"
        },
        {
            "start_pos": 313,
            "end_pos": 313,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Thr",
            "comment": "Phosphothreonine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2A6Q5",
                    "url": "https://www.uniprot.org/uniprot/A2A6Q5"
                }
            ],
            "site_lbl": "Thr313"
        },
        {
            "start_pos": 339,
            "end_pos": 339,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2A6Q5",
                    "url": "https://www.uniprot.org/uniprot/A2A6Q5"
                }
            ],
            "site_lbl": "Ser339"
        },
        {
            "start_pos": 367,
            "end_pos": 367,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Thr",
            "comment": "Phosphothreonine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2A6Q5",
                    "url": "https://www.uniprot.org/uniprot/A2A6Q5"
                }
            ],
            "site_lbl": "Thr367"
        },
        {
            "start_pos": 380,
            "end_pos": 380,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2A6Q5",
                    "url": "https://www.uniprot.org/uniprot/A2A6Q5"
                }
            ],
            "site_lbl": "Ser380"
        },
        {
            "start_pos": 387,
            "end_pos": 387,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2A6Q5",
                    "url": "https://www.uniprot.org/uniprot/A2A6Q5"
                }
            ],
            "site_lbl": "Ser387"
        },
        {
            "start_pos": 427,
            "end_pos": 427,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2A6Q5",
                    "url": "https://www.uniprot.org/uniprot/A2A6Q5"
                }
            ],
            "site_lbl": "Ser427"
        },
        {
            "start_pos": 431,
            "end_pos": 431,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Thr",
            "comment": "Phosphothreonine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2A6Q5",
                    "url": "https://www.uniprot.org/uniprot/A2A6Q5"
                }
            ],
            "site_lbl": "Thr431"
        },
        {
            "start_pos": 436,
            "end_pos": 436,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
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            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2A6Q5",
                    "url": "https://www.uniprot.org/uniprot/A2A6Q5"
                }
            ],
            "site_lbl": "Ser436"
        },
        {
            "start_pos": 439,
            "end_pos": 439,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
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                {
                    "database": "UniProtKB",
                    "id": "A2A6Q5",
                    "url": "https://www.uniprot.org/uniprot/A2A6Q5"
                }
            ],
            "site_lbl": "Ser439"
        },
        {
            "start_pos": 447,
            "end_pos": 447,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Thr",
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            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2A6Q5",
                    "url": "https://www.uniprot.org/uniprot/A2A6Q5"
                }
            ],
            "site_lbl": "Thr447"
        },
        {
            "start_pos": 822,
            "end_pos": 822,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
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            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2A6Q5",
                    "url": "https://www.uniprot.org/uniprot/A2A6Q5"
                }
            ],
            "site_lbl": "Ser822"
        }
    ],
    "glycation": [],
    "keywords": [],
    "publication": [
        {
            "title": "The novel protein MANI modulates neurogenesis and neurite-cone growth.",
            "journal": "J. Cell. Mol. Med.",
            "date": "2011",
            "authors": "Mishra M, Akatsu H, Heese K",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2A6Q5",
                    "url": "https://www.uniprot.org/uniprot/A2A6Q5"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "20716133",
                    "url": "https://glygen.org/publication/PubMed/20716133"
                }
            ]
        }
    ],
    "pathway": [
        {
            "id": "mmu:217232",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:217232",
            "resource": "KEGG Pathway"
        },
        {
            "id": "R-MMU-141430",
            "name": "Inactivation of APC/C via direct inhibition of the APC/C complex",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-141430",
            "resource": "Reactome",
            "description": "Inactivation of APC/C via direct inhibition of the APC/C complex"
        },
        {
            "id": "R-MMU-174048",
            "name": "APC/C:Cdc20 mediated degradation of Cyclin B",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-174048",
            "resource": "Reactome",
            "description": "APC/C:Cdc20 mediated degradation of Cyclin B"
        },
        {
            "id": "R-MMU-174084",
            "name": "Autodegradation of Cdh1 by Cdh1:APC/C",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-174084",
            "resource": "Reactome",
            "description": "Autodegradation of Cdh1 by Cdh1:APC/C"
        },
        {
            "id": "R-MMU-174154",
            "name": "APC/C:Cdc20 mediated degradation of Securin",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-174154",
            "resource": "Reactome",
            "description": "APC/C:Cdc20 mediated degradation of Securin"
        },
        {
            "id": "R-MMU-174178",
            "name": "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-174178",
            "resource": "Reactome",
            "description": "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1"
        },
        {
            "id": "R-MMU-174184",
            "name": "Cdc20:Phospho-APC/C mediated degradation of Cyclin A",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-174184",
            "resource": "Reactome",
            "description": "Cdc20:Phospho-APC/C mediated degradation of Cyclin A"
        },
        {
            "id": "R-MMU-176407",
            "name": "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-176407",
            "resource": "Reactome",
            "description": "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase"
        },
        {
            "id": "R-MMU-176408",
            "name": "Regulation of APC/C activators between G1/S and early anaphase",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-176408",
            "resource": "Reactome",
            "description": "Regulation of APC/C activators between G1/S and early anaphase"
        },
        {
            "id": "R-MMU-176409",
            "name": "APC/C:Cdc20 mediated degradation of mitotic proteins",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-176409",
            "resource": "Reactome",
            "description": "APC/C:Cdc20 mediated degradation of mitotic proteins"
        },
        {
            "id": "R-MMU-176412",
            "name": "Phosphorylation of the APC/C",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-176412",
            "resource": "Reactome",
            "description": "Phosphorylation of the APC/C"
        },
        {
            "id": "R-MMU-179409",
            "name": "APC-Cdc20 mediated degradation of Nek2A",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-179409",
            "resource": "Reactome",
            "description": "APC-Cdc20 mediated degradation of Nek2A"
        },
        {
            "id": "R-MMU-2467813",
            "name": "Separation of Sister Chromatids",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2467813",
            "resource": "Reactome",
            "description": "Separation of Sister Chromatids"
        },
        {
            "id": "R-MMU-2559582",
            "name": "Senescence-Associated Secretory Phenotype (SASP)",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2559582",
            "resource": "Reactome",
            "description": "Senescence-Associated Secretory Phenotype (SASP)"
        },
        {
            "id": "R-MMU-68867",
            "name": "Assembly of the pre-replicative complex",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-68867",
            "resource": "Reactome",
            "description": "Assembly of the pre-replicative complex"
        },
        {
            "id": "R-MMU-69017",
            "name": "CDK-mediated phosphorylation and removal of Cdc6",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-69017",
            "resource": "Reactome",
            "description": "CDK-mediated phosphorylation and removal of Cdc6"
        },
        {
            "id": "R-MMU-983168",
            "name": "Antigen processing: Ubiquitination & Proteasome degradation",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-983168",
            "resource": "Reactome",
            "description": "Antigen processing: Ubiquitination & Proteasome degradation"
        }
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                "length": 824
            },
            "evidence": [
                {
                    "id": "45234983",
                    "url": "http://www.informatics.jax.org/homology/45234983",
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                },
                {
                    "id": "A2A6Q5",
                    "url": "https://omabrowser.org/oma/group/A2A6Q5/",
                    "database": "OMA"
                }
            ],
            "common_name": "Human"
        },
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            "protein_name": "Anaphase-promoting complex subunit CDC27",
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            "sequence": {
                "sequence": "MAVNPELAPFTLSRGIPSFDDQALSTIIQLQDCIQQAIQQLNYSTAEFLAELLYAECSILDKSSVYWSDAVYLYALSLFLNKSYHTAFQISKEFKEYHLGIAYIFGRCALQLSQGVNEAILTLLSIINVFSSNSSNTRINMVLNSNLVHIPDLATLNCLLGNLYMKLDHSKEGAFYHSEALAINPYLWESYEAICKMRATVDLKRVFFDIAGKKSNSHNNNAASSFPSTSLSHFEPRSQPSLYSKTNKNGNNNINNNVNTLFQSSNSPPSTSASSFSSIQHFSRSQQQQANTSIRTCQNKNTQTPKNPAINSKTSSALPNNISMNLVSPSSKQPTISSLAKVYNRNKLLTTPPSKLLNNDRNHQNNNNNNNNNNNNNNNNNNNNNNNNIINKTTFKTPRNLYSSTGRLTTSKKNPRSLIISNSILTSDYSITLPEIMYNFALILRSSSQYNSFKAIRLFESQIPSHIKDTMPWCLVQLGKLHFEIINYDMSLKYFNRLKDLQPARVKDMEIFSTLLWHLHDKVKSSNLANGLMDTMPNKPETWCCIGNLLSLQKDHDAAIKAFEKATQLDPNFAYAYTLQGHEHSSNDSSDSAKTCYRKALACDPQHYNAYYGLGTSAMKLGQYEEALLYFEKARSINPVNVVLICCCGGSLEKLGYKEKALQYYELACHLQPTSSLSKYKMGQLLYSMTRYNVALQTFEELVKLVPDDATAHYLLGQTYRIVGRKKDAIKELTVAMNLDPKGNQVIIDELQKCHMQE",
                "length": 758
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                {
                    "id": "A2A6Q5",
                    "url": "https://omabrowser.org/oma/group/A2A6Q5/",
                    "database": "OMA"
                }
            ],
            "common_name": "Yeast"
        },
        {
            "uniprot_canonical_ac": "Q4V8A2-1",
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            "gene_name": "Cdc27",
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            "organism": "Rattus norvegicus",
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                "length": 824
            },
            "evidence": [
                {
                    "id": "45234983",
                    "url": "http://www.informatics.jax.org/homology/45234983",
                    "database": "MGI"
                }
            ],
            "common_name": "Rat"
        }
    ],
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        "categories": [
            {
                "name": "Cellular Component",
                "total": 7,
                "go_terms": [
                    {
                        "name": "nucleus",
                        "id": "GO:0005634",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2A6Q5",
                                "url": "https://www.uniprot.org/uniprot/A2A6Q5"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "nucleoplasm",
                        "id": "GO:0005654",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2A6Q5",
                                "url": "https://www.uniprot.org/uniprot/A2A6Q5"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cytoplasm",
                        "id": "GO:0005737",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2A6Q5",
                                "url": "https://www.uniprot.org/uniprot/A2A6Q5"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "centrosome",
                        "id": "GO:0005813",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2A6Q5",
                                "url": "https://www.uniprot.org/uniprot/A2A6Q5"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "spindle",
                        "id": "GO:0005819",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005819",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2A6Q5",
                                "url": "https://www.uniprot.org/uniprot/A2A6Q5"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "anaphase-promoting complex",
                        "id": "GO:0005680",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005680",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2A6Q5",
                                "url": "https://www.uniprot.org/uniprot/A2A6Q5"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "mitotic spindle",
                        "id": "GO:0072686",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072686",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2A6Q5",
                                "url": "https://www.uniprot.org/uniprot/A2A6Q5"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Biological Process",
                "total": 5,
                "go_terms": [
                    {
                        "name": "cell division",
                        "id": "GO:0051301",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051301",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2A6Q5",
                                "url": "https://www.uniprot.org/uniprot/A2A6Q5"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "protein ubiquitination",
                        "id": "GO:0016567",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016567",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2A6Q5",
                                "url": "https://www.uniprot.org/uniprot/A2A6Q5"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "anaphase-promoting complex-dependent catabolic process",
                        "id": "GO:0031145",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031145",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2A6Q5",
                                "url": "https://www.uniprot.org/uniprot/A2A6Q5"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "protein K11-linked ubiquitination",
                        "id": "GO:0070979",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070979",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2A6Q5",
                                "url": "https://www.uniprot.org/uniprot/A2A6Q5"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "metaphase/anaphase transition of mitotic cell cycle",
                        "id": "GO:0007091",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007091",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2A6Q5",
                                "url": "https://www.uniprot.org/uniprot/A2A6Q5"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Molecular Function",
                "total": 1,
                "go_terms": [
                    {
                        "name": "protein phosphatase binding",
                        "id": "GO:0019903",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019903",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2A6Q5",
                                "url": "https://www.uniprot.org/uniprot/A2A6Q5"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            }
        ]
    },
    "pro_annotation": [],
    "site_annotation": [
        {
            "start_pos": 175,
            "end_pos": 177,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 190,
            "end_pos": 192,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 300,
            "end_pos": 302,
            "annotation": "n_glycosylation_sequon"
        },
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