{
    "uniprot_canonical_ac": "A2A559-1",
    "uniprot_ac": "A2A559",
    "uniprot_id": "PGAP3_MOUSE",
    "mass": {
        "chemical_mass": 36528.0,
        "monoisotopic_mass": 36528.0
    },
    "refseq": {
        "ac": "NP_001028709",
        "name": "post-GPI attachment to proteins factor 3 precursor",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028709"
    },
    "gene_names": [
        {
            "name": "Pgap3",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/A2A559",
            "id": "A2A559"
        },
        {
            "name": "CAB2; D430035D22Rik; Perld1",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028709",
            "id": "NP_001028709"
        },
        {
            "name": "Perld1",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A2A559",
            "id": "A2A559"
        },
        {
            "name": "Pgap3",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028709",
            "id": "NP_001028709"
        }
    ],
    "protein_names": [
        {
            "name": "Post-GPI attachment to proteins factor 3",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "",
            "id": "A2A559"
        },
        {
            "name": "PER1-like domain-containing protein 1",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "A2A559"
        },
        {
            "name": "per1-like domain containing 1; post-GPI attachment to proteins factor 3; PER1-like domain-containing protein 1",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028709",
            "id": "NP_001028709"
        },
        {
            "name": "post-GPI attachment to proteins factor 3 precursor",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028709",
            "id": "NP_001028709"
        }
    ],
    "function": [
        {
            "annotation": "Involved in the lipid remodeling steps of GPI-anchor maturation. Lipid remodeling steps consist in the generation of 2 saturated fatty chains at the sn-2 position of GPI-anchors proteins. Required for phospholipase A2 activity that removes an acyl-chain at the sn-2 position of GPI-anchors during the remodeling of GPI (By similarity).",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2A559",
                    "url": "https://www.uniprot.org/uniprot/A2A559#function"
                }
            ]
        },
        {
            "annotation": "The response of T cells was enhanced in Pgap3 knockout mice in both in vitro and in vivo studies, including alloreactive response, antigen-specific immune response, and experimental autoimmune encephalomyelitis.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001028709",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028709"
                },
                {
                    "database": "PubMed",
                    "id": "22227195",
                    "url": "https://glygen.org/publication/PubMed/22227195"
                }
            ]
        }
    ],
    "disease": [
        {
            "disease_id": "DOID:0070436",
            "recommended_name": {
                "id": "DOID:0070436",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:0070436",
                "name": "hyperphosphatasia with impaired intellectual development syndrome 4",
                "description": "A hyperphosphatasia with impaired intellectual development syndrome that has_material_basis_in homozygous or compound heterozygous mutation in the PGAP3 gene on chromosome 17q12."
            },
            "synonyms": [
                {
                    "id": "DOID:0070436",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0070436",
                    "name": "HPMRS6",
                    "description": ""
                },
                {
                    "id": "DOID:0070436",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0070436",
                    "name": "hyperphosphatasia with mental retardation syndrome 6",
                    "description": ""
                },
                {
                    "id": "DOID:0070436",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0070436",
                    "name": "GPIBD62",
                    "description": ""
                },
                {
                    "id": "DOID:0070436",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0070436",
                    "name": "glycosylphosphatidylinositol biosynthesis defect 62",
                    "description": ""
                },
                {
                    "id": "MONDO:0014318",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0014318",
                    "name": "hyperphosphatasia with intellectual disability syndrome 4",
                    "description": "Any hyperphosphatasia-intellectual disability syndrome in which the cause of the disease is a mutation in the PGAP3 gene."
                },
                {
                    "id": "MONDO:0014318",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0014318",
                    "name": "PGAP3 hyperphosphatasia-intellectual disability syndrome",
                    "description": ""
                },
                {
                    "id": "MONDO:0014318",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0014318",
                    "name": "hyperphosphatasia with intellectual disability syndrome 4",
                    "description": ""
                },
                {
                    "id": "MONDO:0014318",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0014318",
                    "name": "hyperphosphatasia with intellectual disability syndrome type 4",
                    "description": ""
                },
                {
                    "id": "MONDO:0014318",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0014318",
                    "name": "hyperphosphatasia with mental retardation syndrome 4",
                    "description": ""
                },
                {
                    "id": "MONDO:0014318",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0014318",
                    "name": "hyperphosphatasia with mental retardation syndrome type 4",
                    "description": ""
                },
                {
                    "id": "MONDO:0014318",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0014318",
                    "name": "hyperphosphatasia-intellectual disability syndrome caused by mutation in PGAP3",
                    "description": ""
                },
                {
                    "id": "MONDO:0014318",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0014318",
                    "name": "HPMRS4",
                    "description": ""
                },
                {
                    "id": "MONDO:0014318",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0014318",
                    "name": "glycosylphosphatidylinositol biosynthesis defect 10",
                    "description": ""
                },
                {
                    "id": "MIM:615716",
                    "resource": "MIM",
                    "url": "https://www.omim.org/entry/615716",
                    "name": "Hyperphosphatasia with impaired intellectual development syndrome 4",
                    "description": "Hyperphosphatasia with impaired intellectual development syndrome 4"
                }
            ],
            "evidence": [
                {
                    "id": "0070436",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:0070436"
                }
            ]
        }
    ],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Mus musculus",
            "taxid": 10090,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2A559",
                    "url": "https://www.uniprot.org/uniprot/A2A559"
                }
            ],
            "common_name": "Mouse"
        }
    ],
    "gene": [
        {
            "name": "Pgap3",
            "url": "https://www.uniprot.org/uniprot/A2A559",
            "locus": {
                "chromosome": "11",
                "start_pos": 98279503,
                "end_pos": 98291316,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSMUSG00000038208",
                        "url": "https://www.ensembl.org/id/ENSMUSG00000038208"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSMUSG00000038208",
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000038208",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "320655",
            "url": "https://www.ncbi.nlm.nih.gov/gene/320655",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "IPR007217",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR007217",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "mmu:320655",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:320655",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "2444461",
            "url": "http://www.informatics.jax.org/marker/MGI:2444461",
            "database": "MGI",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "DFMIEDC",
            "url": "https://omabrowser.org/oma/group/DFMIEDC/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "445643at2759",
            "url": "http://www.orthodb.org/?query=445643at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR13148",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13148",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR13148:SF0",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13148:SF0",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF04080",
            "url": "http://pfam.xfam.org/family/PF04080",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PR_A2A559",
            "url": "http://purl.obolibrary.org/obo/PR_A2A559",
            "database": "PRO",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "NP_001028709",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028709",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A2A559",
            "url": "https://www.uniprot.org/uniprot/A2A559",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A2A559-1",
            "url": "https://www.uniprot.org/uniprot/A2A559-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A2A559-2",
            "url": "https://www.uniprot.org/uniprot/A2A559-2",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MAKRTAPLLLLTLAVGLAGGSQGDREPVYRDCVLRCEERNCSGDALKHFRSRQPIYMSLAGWTCRDDCKYECMWFTVGLYLQEGHRVPQFHGKWPFSRFLFIQEPASAVASLLNGLASLVMLCRYRASVPASSPMYHTCMAFAWVSLNAWFWSTVFHTRDTDLTEKMDYFCASAVILHSVYLCCVRTVGLQHPSVASAFGALLLLLLTGHISYLSLVHFDYGYNMMANVAIGLVNLAWWLVWCLRNRQRLPHTRRCMVVVVLLQGLSLLELLDFPPLFWVLDAHAIWHISTIPVHTLFFRFLEDDSLYLLKESGAMFKLD",
        "length": 320,
        "header": "sp|A2A559-1|PGAP3_MOUSE Isoform 1 of Post-GPI attachment to proteins factor 3  OS=Mus musculus OX=10090 GN=Pgap3 PE=2 SV=1 CANONICAL=A2A559-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A2A559-1",
            "url": "",
            "sequence": {
                "sequence": "MAKRTAPLLLLTLAVGLAGGSQGDREPVYRDCVLRCEERNCSGDALKHFRSRQPIYMSLAGWTCRDDCKYECMWFTVGLYLQEGHRVPQFHGKWPFSRFLFIQEPASAVASLLNGLASLVMLCRYRASVPASSPMYHTCMAFAWVSLNAWFWSTVFHTRDTDLTEKMDYFCASAVILHSVYLCCVRTVGLQHPSVASAFGALLLLLLTGHISYLSLVHFDYGYNMMANVAIGLVNLAWWLVWCLRNRQRLPHTRRCMVVVVLLQGLSLLELLDFPPLFWVLDAHAIWHISTIPVHTLFFRFLEDDSLYLLKESGAMFKLD",
                "length": 320,
                "header": "sp|A2A559-1|PGAP3_MOUSE Isoform 1 of Post-GPI attachment to proteins factor 3  OS=Mus musculus OX=10090 GN=Pgap3 PE=2 SV=1 CANONICAL=A2A559-1"
            },
            "locus": {
                "chromosome": "11",
                "start_pos": 98291221,
                "end_pos": 98280867,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000090827",
                        "url": "https://www.ensembl.org/id/ENSMUST00000090827"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000088337",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000088337"
                    }
                ]
            }
        },
        {
            "isoform_ac": "A2A559-2",
            "url": "",
            "sequence": {
                "sequence": "MAKRTAPLLLLTLAVGLAGGSQGDREPVYRDCVLRCEERNCSGDALKHFRSRQPIYMSLAGWTCRDDCKYECMWFTVGLYLQEGHRVPQFHGKVSLNAWFWSTVFHTRDTDLTEKMDYFCASAVILHSVYLCCVRTVGLQHPSVASAFGALLLLLLTGHISYLSLVHFDYGYNMMANVAIGLVNLAWWLVWCLRNRQRLPHTRRCMVVVVLLQGLSLLELLDFPPLFWVLDAHAIWHISTIPVHTLFFRFLEDDSLYLLKESGAMFKLD",
                "length": 269,
                "header": "sp|A2A559-2|PGAP3_MOUSE Isoform 2 of Post-GPI attachment to proteins factor 3  OS=Mus musculus OX=10090 GN=Pgap3 PE=2 SV=1 CANONICAL=A2A559-1"
            },
            "locus": {
                "chromosome": "11",
                "start_pos": 98291221,
                "end_pos": 98280867,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000128897",
                        "url": "https://www.ensembl.org/id/ENSMUST00000128897"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000119668",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000119668"
                    }
                ]
            }
        }
    ],
    "glycosylation": [
        {
            "glytoucan_ac": "",
            "type": "N-linked",
            "subtype": "",
            "site_category": "predicted",
            "site_seq": "N",
            "relation": "attached",
            "comment": "N-linked (GlcNAc...) asparagine",
            "start_pos": 40,
            "start_aa": "Asn",
            "end_pos": 40,
            "end_aa": "Asn",
            "residue": "Asn",
            "site_lbl": "Asn40",
            "evidence": [
                {
                    "id": "A2A559",
                    "database": "UniProtKB",
                    "url": "https://www.uniprot.org/uniprot/A2A559#ptm_processing"
                }
            ]
        }
    ],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [
        "glycoprotein",
        "glycoprotein_predicted"
    ],
    "publication": [
        {
            "title": "Enhanced response of T lymphocytes from Pgap3 knockout mouse: Insight into roles of fatty acid remodeling of GPI anchored proteins.",
            "journal": "Biochemical and biophysical research communications",
            "date": "2012",
            "authors": "Murakami H, Wang Y, Hasuwa H, Maeda Y, Kinoshita T, Murakami Y",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001028709",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028709"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "22227195",
                    "url": "https://glygen.org/publication/PubMed/22227195"
                }
            ]
        }
    ],
    "pathway": [
        {
            "id": "mmu:320655",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:320655",
            "resource": "KEGG Pathway"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "A6HIS2-1",
            "protein_name": "Post-GPI attachment to proteins factor 3",
            "gene_name": "Perld1",
            "tax_id": 10116,
            "organism": "Rattus norvegicus",
            "sequence": {
                "sequence": "MARRTAPLLLLTLAVGLAGSSQGDREPVYRDCVLRCEERNCSGDALKHFRSRQPIYMSLAGWTCRDDCKYECMWLTVGLYLQEGYRVPQFHGKWPFSRFLFIQEPASALASLLNGLASLVMLCRYRASVPASSPMYHTCMAFAWVSLNAWFWSTVFHTRDTDLTEKMDYFCASAVILHSVYLCCVRTVGLQHPTVASAFGALLLLLLTGHISYLSLVHFDYGYNMMANVAIGLVNLAWWLVWCLRNHRRLPHTRRCMVVVVLLQGLSLLELLDFPPLFWVLDAHAIWHISTIPVHTLFFRFLEDDSLYLLKESEAMFKLD",
                "length": 320
            },
            "evidence": [
                {
                    "id": "45239739",
                    "url": "http://www.informatics.jax.org/homology/45239739",
                    "database": "MGI"
                }
            ],
            "common_name": "Rat"
        },
        {
            "uniprot_canonical_ac": "P25625-1",
            "protein_name": "Protein PER1",
            "gene_name": "PER1",
            "tax_id": 559292,
            "organism": "Saccharomyces cerevisiae S288C",
            "sequence": {
                "sequence": "MRLAVVVTLLVHCFLVTCSPGDNLDEFIDCTYACEYNRRCPNSQINYIDPETNMFHDIEFFDTPPLYSKLLFWDCISDCDYQCQHIITRWRIDEEEEIYQFHGKWPFLRVLGTQEFFSTIFSIGNFIPHYKGFVKFSRIIREEGDRRRKNSRSILIWNYLYVTVAGMLAWTASSVFHCRDLIITEKLDYFFAGLTVLTGFHAIFARMTSMFLYPKIAQAFTASVAAIFALHILRLYVDWSYTYNMRFNIFFGVLQYILLIMLSCQNYHALQKQKLMGEFKKTAYSSFKRQIFKLCVIPILLVIVTTMAMSLELFDFFSYEWQIDAHALWHLCTIWPSWVLYDFFLEDYAYWGNRQLY",
                "length": 357
            },
            "evidence": [
                {
                    "id": "A2A559",
                    "url": "https://omabrowser.org/oma/group/A2A559/",
                    "database": "OMA"
                }
            ],
            "common_name": "Yeast"
        },
        {
            "uniprot_canonical_ac": "Q7K0P4-1",
            "protein_name": "Post-GPI attachment to proteins factor 3",
            "gene_name": "PGAP3",
            "tax_id": 7227,
            "organism": "Drosophila melanogaster",
            "sequence": {
                "sequence": "MSSRSLSAIVLLLGALVTACLASNGDRTQFFHNCRQNCERTNCSADGLEIQEQAVKFYQQSVFDRLFQWSCADECQYGCMWRTVFAFFERGWPIPQFYGKWPFLRLLGMQEPASVIFSCLNFVVHLRLLRKFRREVRPDSPCYMLTHIFAVTSLNGWIWSAIFHTRDFPLTELLDYAFAYSIILCSLYVMVMRMLHRYSLFLRGVITLAFLSYYINYFAYLSVGRFNYAFNMMVNVATGVIAAVGWFVWCHFVRTRRPYFRRILRFYILMALAMSLELLDFPPILWILDAHALWHLATIPLASLYYECVEILLYSNIATCVCILAS",
                "length": 326
            },
            "evidence": [
                {
                    "id": "A2A559",
                    "url": "https://omabrowser.org/oma/group/A2A559/",
                    "database": "OMA"
                }
            ],
            "common_name": "Fruit fly"
        },
        {
            "uniprot_canonical_ac": "Q96FM1-1",
            "protein_name": "Post-GPI attachment to proteins factor 3",
            "gene_name": "PGAP3",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MAGLAARLVLLAGAAALASGSQGDREPVYRDCVLQCEEQNCSGGALNHFRSRQPIYMSLAGWTCRDDCKYECMWVTVGLYLQEGHKVPQFHGKWPFSRFLFFQEPASAVASFLNGLASLVMLCRYRTFVPASSPMYHTCVAFAWVSLNAWFWSTVFHTRDTDLTEKMDYFCASTVILHSIYLCCVRTVGLQHPAVVSAFRALLLLMLTVHVSYLSLIRFDYGYNLVANVAIGLVNVVWWLAWCLWNQRRLPHVRKCVVVVLLLQGLSLLELLDFPPLFWVLDAHAIWHISTIPVHVLFFSFLEDDSLYLLKESEDKFKLD",
                "length": 320
            },
            "evidence": [
                {
                    "id": "45239739",
                    "url": "http://www.informatics.jax.org/homology/45239739",
                    "database": "MGI"
                },
                {
                    "id": "A2A559",
                    "url": "https://omabrowser.org/oma/group/A2A559/",
                    "database": "OMA"
                }
            ],
            "common_name": "Human"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Cellular Component",
                "total": 2,
                "go_terms": [
                    {
                        "name": "Golgi membrane",
                        "id": "GO:0000139",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000139",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2A559",
                                "url": "https://www.uniprot.org/uniprot/A2A559"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "endoplasmic reticulum membrane",
                        "id": "GO:0005789",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2A559",
                                "url": "https://www.uniprot.org/uniprot/A2A559"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Molecular Function",
                "total": 1,
                "go_terms": [
                    {
                        "name": "hydrolase activity, acting on ester bonds",
                        "id": "GO:0016788",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016788",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2A559",
                                "url": "https://www.uniprot.org/uniprot/A2A559"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Biological Process",
                "total": 2,
                "go_terms": [
                    {
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