{ "uniprot_canonical_ac": "A1L1K7-1", "uniprot_ac": "A1L1K7", "uniprot_id": "ACBG2_RAT", "mass": { "chemical_mass": 74266.0, "monoisotopic_mass": 74266.0 }, "refseq": { "ac": "NP_001073565", "name": "long-chain-fatty-acid--CoA ligase ACSBG2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073565" }, "gene_names": [ { "name": "Acsbg2", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A1L1K7", "id": "A1L1K7" }, { "name": "Acsbg2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073565", "id": "NP_001073565" } ], "protein_names": [ { "name": "Long-chain-fatty-acid--CoA ligase ACSBG2", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "A1L1K7" }, { "name": "6.2.1.15", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "A1L1K7" }, { "name": "6.2.1.3", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "A1L1K7" }, { "name": "Acyl-CoA synthetase bubblegum family member 2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "A1L1K7" }, { "name": "Arachidonate--CoA ligase ACSBG2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "A1L1K7" }, { "name": "bubblegum-related acyl-CoA synthetase 2; arachidonate--CoA ligase ACSBG2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073565", "id": "NP_001073565" }, { "name": "long-chain-fatty-acid--CoA ligase ACSBG2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073565", "id": "NP_001073565" } ], "function": [ { "annotation": "Catalyzes the conversion of fatty acids such as long chain and very long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation. Can activate diverse saturated, monosaturated and polyunsaturated fatty acids. Has increased ability to activate oleic and linoleic acid. May play a role in spermatogenesis.", "evidence": [ { "database": "UniProtKB", "id": "A1L1K7", "url": "https://www.uniprot.org/uniprot/A1L1K7#function" }, { "database": "UniProtKB", "id": "Q5FVE4", "url": "https://www.uniprot.org/uniprot/Q5FVE4#function" } ] } ], "disease": [ { "disease_id": "DOID:10588", "recommended_name": { "id": "DOID:10588", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10588", "name": "adrenoleukodystrophy", "description": "A leukodystrophy that disrupts the breakdown of very-long-chain fatty acids resulting in progressive brain damage, failure of the adrenal glands and eventually death." }, "synonyms": [ { "id": "DOID:10588", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10588", "name": "ALD", "description": "" }, { "id": "DOID:10588", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10588", "name": "Bronze Schilder disease", "description": "" }, { "id": "DOID:10588", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10588", "name": "Encephalitis periaxialis concentrica", "description": "" }, { "id": "DOID:10588", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10588", "name": "Encephalitis periaxialis, Schilder's", "description": "" }, { "id": "DOID:10588", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10588", "name": "Siemerling-Creutzfeldt Disease", "description": "" }, { "id": "DOID:10588", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10588", "name": "X-linked adrenoleukodystrophy", "description": "" }, { "id": "DOID:10588", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10588", "name": "diffuse sclerosis", "description": "" }, { "id": "DOID:10588", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10588", "name": "sudanophilic cerebral sclerosis", "description": "" }, { "id": "MONDO:0018544", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018544", "name": "adrenoleukodystrophy", "description": "A peroxisomal disorder resulting in cerebral demyelination, axonal dysfunction in the spinal cord leading to spastic paraplegia, adrenal insufficiency and in some cases testicular insufficiency." }, { "id": "MONDO:0018544", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018544", "name": "ABCD1 deficiency", "description": "" }, { "id": "MONDO:0018544", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018544", "name": "ALD", "description": "" }, { "id": "MONDO:0018544", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018544", "name": "Bronze-Schilder disease", "description": "" }, { "id": "MONDO:0018544", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018544", "name": "Siemerling-Creutzfeldt disease", "description": "" }, { "id": "MONDO:0018544", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018544", "name": "X-ALD", "description": "" }, { "id": "MONDO:0018544", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018544", "name": "X-linked ALD", "description": "" }, { "id": "MONDO:0018544", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018544", "name": "X-linked adrenoleukodystrophy", "description": "" }, { "id": "MONDO:0018544", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018544", "name": "adrenoleukodystrophy", "description": "" }, { "id": "MONDO:0018544", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018544", "name": "adrenoleukodystrophy, X-linked", "description": "" }, { "id": "MONDO:0018544", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018544", "name": "adrenoleukodystrophy, X-linked recessive", "description": "" }, { "id": "MONDO:0018544", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018544", "name": "adrenomyeloneuropathy, adult", "description": "" }, { "id": "MONDO:0018544", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018544", "name": "adrenomyeloneuropathy, adult, X-linked recessive", "description": "" }, { "id": "MONDO:0018544", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018544", "name": "diffuse cerebral sclerosis of Schilder", "description": "" }, { "id": "MONDO:0018544", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018544", "name": "encephalitis periaxialis concentrica", "description": "" }, { "id": "MONDO:0018544", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018544", "name": "encephalitis periaxialis, Schilder's", "description": "" }, { "id": "MONDO:0018544", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018544", "name": "sudanophilic cerebral sclerosis", "description": "" }, { "id": "MONDO:0018544", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018544", "name": "diffuse sclerosis", "description": "" }, { "id": "MIM:300100", "resource": "MIM", "url": "https://www.omim.org/entry/300100", "name": "Adrenoleukodystrophy", "description": "Adrenoleukodystrophy" } ], "evidence": [ { "id": "10588", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:10588" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "A1L1K7", "url": "https://www.uniprot.org/uniprot/A1L1K7" } ], "common_name": "Rat" } ], "gene": [ { "name": "Acsbg2", "url": "https://www.uniprot.org/uniprot/A1L1K7", "locus": { "chromosome": "9", "start_pos": 1683847, "end_pos": 1714518, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000045947", "url": "https://www.ensembl.org/id/ENSRNOG00000045947" } ] } } ], "crossref": [ { "id": "ENSRNOG00000045947", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000045947", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd05933", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd05933", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "301120", "url": "https://www.ncbi.nlm.nih.gov/gene/301120", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000873", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000873", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020845", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020845", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042099", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042099", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "rno:301120", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:301120", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "FNRPGPN", "url": "https://omabrowser.org/oma/group/FNRPGPN/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "443463at2759", "url": "http://www.orthodb.org/?query=443463at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR43272", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43272", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR43272:SF101", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43272:SF101", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00501", "url": "http://pfam.xfam.org/family/PF00501", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_A1L1K7", "url": "http://purl.obolibrary.org/obo/PR_A1L1K7", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-RNO-75876", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-75876", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_001073565", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073565", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "1588580", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1588580", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "15421", "url": "https://www.rhea-db.org/rhea/15421", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "19713", "url": "https://www.rhea-db.org/rhea/19713", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "30751", "url": "https://www.rhea-db.org/rhea/30751", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "33607", "url": "https://www.rhea-db.org/rhea/33607", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "33639", "url": "https://www.rhea-db.org/rhea/33639", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "33651", "url": "https://www.rhea-db.org/rhea/33651", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A1L1K7", "url": "https://www.uniprot.org/uniprot/A1L1K7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A1L1K7-1", "url": "https://www.uniprot.org/uniprot/A1L1K7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTQEKKAEDPDRGMDTTSAAPRLWSTHCDGEVLLRLSKHGPGHETPMTIPELFQESVERFGAYPALASKNGKKWDTLTFSQYYDVCRKAARSLIKLGLQRFHGVGILGFNSVEWVVAALGAILAGGLCVGIYATNSAEACQYVIKQANVNVLIVENDQQLQKILSIPPDKMETVKAIVQYRLPLMENSTNLYSWQDFMELGNAIPNIQLDRVILSQKANQCAVIIYTSGTTGSPKGVMLSHDNITWTAGAMAREIELIHVSGKQDTIVSYLPLSHIAAQLMDIWIPIKVGVLTFFAQPDALRGTLVYTLQEVKPTYFLGVPRVWEKMQDTIKENVAKSSNLRKKAFAWAKMLGLKVNTKKMLGKRDIPMNYRMAKALVFTKVRTSLGLDNCHTFFSGASPLSQDVSEFFLSLDIPIGEIYGMTECSGPHTVSCKSIYRVLSCGKVLNGCKNMLYKQNKDGVGEVCMWGRHVFMGYLGKEDATLEVLDEDGWLHSGDIGRLDSHDFLYITGRIKEVLITAGGENIWPIPIETLVKEKIPIISHAMLVGDKAKFLSMLLTLKCETDQMSGEPLDKLNLEAISFCQMLGSQAVTVSDILKIRDPVVYTAIQYGIDIVNQQAVSDSHRIRKWIILEKDFSIQGGELGPTSKLKRDLITQKYKAQIDNMYSS", "length": 667, "header": "sp|A1L1K7-1|ACBG2_RAT Isoform 1 of Long-chain-fatty-acid--CoA ligase ACSBG2 OS=Rattus norvegicus OX=10116 GN=Acsbg2 PE=2 SV=1 CANONICAL=A1L1K7-1" }, "isoforms": [ { "isoform_ac": "A1L1K7-1", "url": "", "sequence": { "sequence": "MTQEKKAEDPDRGMDTTSAAPRLWSTHCDGEVLLRLSKHGPGHETPMTIPELFQESVERFGAYPALASKNGKKWDTLTFSQYYDVCRKAARSLIKLGLQRFHGVGILGFNSVEWVVAALGAILAGGLCVGIYATNSAEACQYVIKQANVNVLIVENDQQLQKILSIPPDKMETVKAIVQYRLPLMENSTNLYSWQDFMELGNAIPNIQLDRVILSQKANQCAVIIYTSGTTGSPKGVMLSHDNITWTAGAMAREIELIHVSGKQDTIVSYLPLSHIAAQLMDIWIPIKVGVLTFFAQPDALRGTLVYTLQEVKPTYFLGVPRVWEKMQDTIKENVAKSSNLRKKAFAWAKMLGLKVNTKKMLGKRDIPMNYRMAKALVFTKVRTSLGLDNCHTFFSGASPLSQDVSEFFLSLDIPIGEIYGMTECSGPHTVSCKSIYRVLSCGKVLNGCKNMLYKQNKDGVGEVCMWGRHVFMGYLGKEDATLEVLDEDGWLHSGDIGRLDSHDFLYITGRIKEVLITAGGENIWPIPIETLVKEKIPIISHAMLVGDKAKFLSMLLTLKCETDQMSGEPLDKLNLEAISFCQMLGSQAVTVSDILKIRDPVVYTAIQYGIDIVNQQAVSDSHRIRKWIILEKDFSIQGGELGPTSKLKRDLITQKYKAQIDNMYSS", "length": 667, "header": "sp|A1L1K7-1|ACBG2_RAT Isoform 1 of Long-chain-fatty-acid--CoA ligase ACSBG2 OS=Rattus norvegicus OX=10116 GN=Acsbg2 PE=2 SV=1 CANONICAL=A1L1K7-1" }, "locus": { "chromosome": "9", "start_pos": 1712946, "end_pos": 1686101, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000074555", "url": "https://www.ensembl.org/id/ENSRNOT00000074555" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000066937", "url": "https://www.ensembl.org/id/ENSRNOP00000066937" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "rno:301120", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:301120", "resource": "KEGG Pathway" }, { "id": "R-RNO-75876", "name": "Synthesis of very long-chain fatty acyl-CoAs", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-75876", "resource": "Reactome", "description": "Synthesis of very long-chain fatty acyl-CoAs" } ], "orthologs": [ { "uniprot_canonical_ac": "Q2XU92-1", "protein_name": "Long-chain-fatty-acid--CoA ligase ACSBG2", "gene_name": "Acsbg2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MTQEKKAEDLERGTDATSAVPRLWSTHCDGEVLLRLSKHGPGHETPMTIPELFQESAERFSAYPALASKNGKKWDTLTFSQYYEMCRKAAKSLIKLGLQRFQCVGILGFNSVEWVVTALGTILAGGLCVGIYATNSAEACQYVIQQANVSILIVENDQQLQKILLIPPDKMETVKAIVQYKLPLMESMANLYSWNDFMELGNDIPNIQLDRVILSQKANQCAVILYTSGTTGTPKGVLLSHDNITWTAGAMSQEMEINRVSGKQNTIVSYLPLSHIAAQLTDIWIPIKIGALTFFAQPDALRGTLVYTLQEVKPTLFMGVPRIWEKMQDTIKENVARSSRLRKKAFAWAKMLGLKVNTKRMLGKRDIPMNYRMAKALVFAKVRTSLGLDNCHAFFSSASPLSQDVSEFFLSLDIPIGEIYGMSECSGPHTVSNKSVYRVLSCGKVLSGCKNMLYNQNKEGVGEVCMWGRHVFMGYLNKEEATLEALDENGWLHSGDIGRLDSHDFLYITGRIKEILITAGGENVSPIPIETLVKEKIPIISHAMLVGDKAKFLCMLLTLKCETDRKSGEPLNKLSVEAKSFCQMLGSQATTVSDILKSRDQVVYTAIQYGIDIVNQQAMSDSHRIRKWIILEKDFSIQGGELGPTSKLKRSVITQKYKAQIDSMYLS", "length": 667 }, "evidence": [ { "id": "45231712", "url": "http://www.informatics.jax.org/homology/45231712", "database": "MGI" }, { "id": "A1L1K7", "url": "https://omabrowser.org/oma/group/A1L1K7/", "database": "OMA" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q5FVE4-1", "protein_name": "Long-chain-fatty-acid--CoA ligase ACSBG2", "gene_name": "ACSBG2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MTGTPKTQEGAKDLEVDMNKTEVTPRLWTTCRDGEVLLRLSKHGPGHETPMTIPEFFRESVNRFGTYPALASKNGKKWEILNFNQYYEACRKAAKSLIKLGLERFHGVGILGFNSAEWFITAVGAILAGGLCVGIYATNSAEVCQYVITHAKVNILLVENDQQLQKILSIPQSSLEPLKAIIQYRLPMKKNNNLYSWDDFMELGRSIPDTQLEQVIESQKANQCAVLIYTSGTTGIPKGVMLSHDNITWIAGAVTKDFKLTDKHETVVSYLPLSHIAAQMMDIWVPIKIGALTYFAQADALKGTLVSTLKEVKPTVFIGVPQIWEKIHEMVKKNSAKSMGLKKKAFVWARNIGFKVNSKKMLGKYNTPVSYRMAKTLVFSKVKTSLGLDHCHSFISGTAPLNQETAEFFLSLDIPIGELYGLSESSGPHTISNQNNYRLLSCGKILTGCKNMLFQQNKDGIGEICLWGRHIFMGYLESETETTEAIDDEGWLHSGDLGQLDGLGFLYVTGHIKEILITAGGENVPPIPVETLVKKKIPIISNAMLVGDKLKFLSMLLTLKCEMNQMSGEPLDKLNFEAINFCRGLGSQASTVTEIVKQQDPLVYKAIQQGINAVNQEAMNNAQRIEKWVILEKDFSIYGGELGPMMKLKRHFVAQKYKKQIDHMYH", "length": 666 }, "evidence": [ { "id": "45231712", "url": "http://www.informatics.jax.org/homology/45231712", "database": "MGI" }, { "id": "A1L1K7", "url": "https://omabrowser.org/oma/group/A1L1K7/", "database": "OMA" } ], "common_name": "Human" }, { "uniprot_canonical_ac": "Q9V3S9-1", "protein_name": "Very long-chain-fatty-acid--CoA ligase bubblegum", "gene_name": "bgm", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MSTIDALYNRPGPNRLRQADAYRTTNRQDAVKIRMAKDGIGAEEPISVPGLLKRTVNNYGDYPALRTKNGKNGYHTVTYKQYEQKVHQVAKAFIKLGLEEHHSVGVLAFNCAEWFYSAMGAIHARGIIAGIYTTNSADAVQHVLESSHAQIVVVDDAKQMDKIHAIRDKLPKLKAAIQIQEPYSPYLKKEDGYYRWSEIESMNVSDVEDQYMTRLENVAINECCCLVYTSGTVGMPKGVMLSHDNITFDVRGIVKAMDRVVVGAESIVSYLPLSHVAAQTVDIYTCAFVAGCIWFADKDALKGTLVKSLQDARPTRFMGVPRVYEKFQERMVAVASSSGSLKKMLASWAKGITLKHYMVSQGKSSGGFRYKIAKSLIMSKVKQALGFDRVLTLASAAAPMSPETKKYFLSLDLKIVDAFGMSETAGCHTICLPDSVGLNTIGKTLPGCESKFINKDANGHGELCIRGRHVFMGYIDNKEKTEESLDDDCWLHSGDLGFVDDKGYVSLTGRSKEIIITAGGENIPPVHIENTIKKELDAISNAFLVGEQRKYLTVLITLKTEVDKDSGEPLDELSHESSVWVKSLGVEHKTVSDILAAGPCPKVWKSIEDAIKRANKQSISNAQKVQKFTILPHDFSIPTGELGPTLKVKRNVVSKMYADEIEKLYA", "length": 666 }, "evidence": [ { "id": "A1L1K7", "url": "https://omabrowser.org/oma/group/A1L1K7/", "database": "OMA" } ], "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A1L1K7", "url": "https://www.uniprot.org/uniprot/A1L1K7" } ], "pmid": "" }, { "name": "acyl-CoA hydrolase activity", "id": "GO:0047617", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0047617", "evidence": [ { "database": "UniProtKB", "id": "A1L1K7", "url": "https://www.uniprot.org/uniprot/A1L1K7" } ], "pmid": "" }, { "name": "long-chain fatty acid-CoA ligase activity", "id": "GO:0004467", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004467", "evidence": [ { "database": "UniProtKB", "id": "A1L1K7", "url": "https://www.uniprot.org/uniprot/A1L1K7" } ], "pmid": "" }, { "name": "arachidonate-CoA ligase activity", "id": "GO:0047676", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0047676", "evidence": [ { "database": "UniProtKB", "id": "A1L1K7", "url": "https://www.uniprot.org/uniprot/A1L1K7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A1L1K7", "url": "https://www.uniprot.org/uniprot/A1L1K7" } ], "pmid": "" }, { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "A1L1K7", "url": "https://www.uniprot.org/uniprot/A1L1K7" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A1L1K7", "url": "https://www.uniprot.org/uniprot/A1L1K7" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A1L1K7", "url": "https://www.uniprot.org/uniprot/A1L1K7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "fatty acid metabolic process", "id": "GO:0006631", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006631", "evidence": [ { "database": "UniProtKB", "id": "A1L1K7", "url": "https://www.uniprot.org/uniprot/A1L1K7" } ], "pmid": "" }, { "name": "spermatogenesis", "id": "GO:0007283", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007283", "evidence": [ { "database": "UniProtKB", "id": "A1L1K7", "url": "https://www.uniprot.org/uniprot/A1L1K7" } ], "pmid": "" }, { "name": "cell differentiation", "id": "GO:0030154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "database": "UniProtKB", "id": "A1L1K7", "url": "https://www.uniprot.org/uniprot/A1L1K7" } ], "pmid": "" }, { "name": "long-chain fatty acid biosynthetic process", "id": "GO:0042759", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042759", "evidence": [ { "database": "UniProtKB", "id": "A1L1K7", "url": "https://www.uniprot.org/uniprot/A1L1K7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 187, "end_pos": 189, "annotation": "n_glycosylation_sequon" }, { "start_pos": 243, "end_pos": 245, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "15421", "name": "", "equation": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O35547-1", "O88813-1", "Q63151-1", "P18163-1", "A1L1K7-1", "P33124-1", "Q924N5-1", "P97524-1", "P97849-1", "Q9ES38-1", "Q9UKU0-4", "O95573-1", "P33121-1", "O60488-1", "Q96GR2-1", "Q5FVE4-1", "Q9ULC5-1", "O14975-1", "Q6PCB7-1", "Q6P1M0-1", "Q9Y2P5-1", "Q9Y2P4-1", "Q5K4L6-1", "Q91WC3-1", "Q8JZR0-1", "P41216-1", "Q2XU92-1", "Q99PU5-1", "Q9CZW4-1", "Q9QUJ7-1", "O35488-1", "Q60714-1", "Q91VE0-1", "E9Q9W4-1", "O88561-1", "Q4LDG0-1", "P30624-1", "P39002-1", "P39518-1", "P47912-1", "Q1ZXQ4-1", "Q55DR6-1", "Q9VVT8-1", "Q9V3U0-1", "Q9V3S9-1" ], "evidence": [ { "id": "15421", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/15421" } ] }, { "id": "19713", "name": "", "equation": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O35547-1", "O88813-1", "Q63151-1", "P18163-1", "A1L1K7-1", "P33124-1", "P97524-1", "P97849-1", "Q9UKU0-4", "O95573-1", "P33121-1", "O60488-1", "Q5FVE4-1", "Q9ULC5-1", "O14975-1", "Q6PCB7-1", "Q6P1M0-1", "Q9Y2P4-1", "Q5K4L6-1", "Q91WC3-1", "Q8JZR0-1", "P41216-1", "Q2XU92-1", "Q9CZW4-1", "Q9QUJ7-1", "O35488-1", "Q60714-1", "E9Q9W4-1", "O88561-1", "Q91VE0-1", "Q9VVT8-1" ], "evidence": [ { "id": "19713", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/19713" } ] }, { "id": "30751", "name": "", "equation": "ATP + CoA + hexadecanoate = AMP + diphosphate + hexadecanoyl-CoA", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O35547-1", "O88813-1", "P18163-1", "A1L1K7-1", "P33124-1", "Q924N5-1", "P97524-1", "Q63151-1", "Q9UKU0-4", "P33121-1", "O60488-1", "Q08AH1-1", "Q96GR2-1", "Q5FVE4-1", "Q9ULC5-1", "O14975-1", "Q6P1M0-1", "Q5K4L6-1", "O95573-1", "Q91WC3-1", "Q91VA0-1", "Q8JZR0-1", "P41216-1", "Q2XU92-1", "Q99PU5-1", "Q9QUJ7-1", "O35488-1", "Q9CZW4-1", "O88561-1", "Q91VE0-1", "P30624-1", "P39002-1", "P39518-1", "P47912-1", "Q9VVT8-1" ], "evidence": [ { "id": "30751", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/30751" } ] }, { "id": "33607", "name": "", "equation": "(9Z)-octadecenoate + ATP + CoA = (9Z)-octadecenoyl-CoA + AMP + diphosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A1L1K7-1", "Q63151-1", "P18163-1", "P97524-1", "Q5FVE4-1", "P33121-1", "Q6P1M0-1", "Q9Y2P4-1", "Q5K4L6-1", "O95573-1", "O14975-1", "Q2XU92-1", "P41216-1", "Q9CZW4-1", "E9Q9W4-1", "O88561-1", "Q91VE0-1", "O35488-1", "P30624-1", "P39002-1", "P39518-1", "P47912-1" ], "evidence": [ { "id": "33607", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/33607" } ] }, { "id": "33639", "name": "", "equation": "ATP + CoA + tetracosanoate = AMP + diphosphate + tetracosanoyl-CoA", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A1L1K7-1", "P97524-1", "Q9ES38-1", "P97849-1", "Q4G176-1", "Q5FVE4-1", "Q9Y2P5-1", "O14975-1", "Q6PCB7-1", "Q6P1M0-1", "Q9Y2P4-1", "Q5K4L6-1", "Q3URE1-1", "Q2XU92-1", "O35488-1", "Q4LDG0-1", "Q60714-1", "E9Q9W4-1", "O88561-1", "Q91VE0-1", "P38225-1" ], "evidence": [ { "id": "33639", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/33639" } ] }, { "id": "33651", "name": "", "equation": "(9Z,12Z)-octadecadienoate + ATP + CoA = (9Z,12Z)-octadecadienoyl-CoA + AMP + diphosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A1L1K7-1", "Q63151-1", "Q5FVE4-1", "Q5K4L6-1", "O95573-1", "Q2XU92-1", "Q9CZW4-1", "O88561-1", "P30624-1", "P39002-1", "P39518-1" ], "evidence": [ { "id": "33651", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/33651" } ] }, { "id": "R-RNO-5695957", "name": "ACSBG1,2 ligates CoA-SH to VLCFA, forming VLCFA-CoA", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [ "R-ALL-5695985" ], "output_participant_list": [ "R-ALL-5695971" ], "enzyme_list": [ "Q924N5-1", "A1L1K7-1" ], "evidence": [ { "id": "R-RNO-5695957", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5695957" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-5695971", "participant_name": "VLCFA-CoA [cytosol]", "crossref": [ { "id": "61910", "database": "ChEBI", "url": "" }, { "id": "61910", "database": "ChEBI", "url": "" }, { "id": "61910", "database": "ChEBI", "url": "" }, { "id": "61910", "database": "ChEBI", "url": "" }, { "id": "61910", "database": "ChEBI", "url": "" } ] }, { "participant_id": "R-ALL-5695985", "participant_name": "VLCFA [cytosol]", "crossref": [ { "id": "27283", "database": "ChEBI", "url": "" }, { "id": "27283", "database": "ChEBI", "url": "" }, { "id": "27283", "database": "ChEBI", "url": "" }, { "id": "27283", "database": "ChEBI", "url": "" }, { "id": "27283", "database": "ChEBI", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A1L1K7", "gene_name": "Acsbg2", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "A1L1K7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A1L1K7" } ] }, { "ec_number": "6.2.1.15", "activity": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "A1L1K7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A1L1K7" } ] }, { "ec_number": "6.2.1.3", "activity": "", "evidence": [ { "id": "A1L1K7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A1L1K7" } ] } ] }, { "uniprot_ac": "E9Q9W4", "gene_name": "Slc27a6", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "E9Q9W4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9Q9W4" } ] }, { "ec_number": "6.2.1.-", "activity": "", "evidence": [ { "id": "E9Q9W4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9Q9W4" } ] }, { "ec_number": "6.2.1.15", "activity": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "E9Q9W4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9Q9W4" } ] } ] }, { "uniprot_ac": "O14975", "gene_name": "SLC27A2", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "O14975", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14975" } ] }, { "ec_number": "6.2.1.-", "activity": "", "evidence": [ { "id": "O14975", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14975" } ] }, { "ec_number": "6.2.1.7", "activity": "(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + ATP + CoA = (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "O14975", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14975" } ] }, { "ec_number": "6.2.1.24", "activity": "3,7,11,15-tetramethylhexadecanoate + ATP + CoA = AMP + diphosphate + phytanoyl-CoA.", "evidence": [ { "id": "O14975", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14975" } ] }, { "ec_number": "6.2.1.15", "activity": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "O14975", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14975" } ] } ] }, { "uniprot_ac": "O35488", "gene_name": "Slc27a2", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "O35488", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35488" } ] }, { "ec_number": "6.2.1.-", "activity": "", "evidence": [ { "id": "O35488", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35488" } ] }, { "ec_number": "6.2.1.7", "activity": "(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + ATP + CoA = (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "O35488", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35488" } ] }, { "ec_number": "6.2.1.24", "activity": "3,7,11,15-tetramethylhexadecanoate + ATP + CoA = AMP + diphosphate + phytanoyl-CoA.", "evidence": [ { "id": "O35488", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35488" } ] }, { "ec_number": "6.2.1.15", "activity": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "O35488", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35488" } ] } ] }, { "uniprot_ac": "O35547", "gene_name": "Acsl4", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "O35547", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35547" } ] }, { "ec_number": "6.2.1.15", "activity": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "O35547", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35547" } ] }, { "ec_number": "6.2.1.3", "activity": "", "evidence": [ { "id": "O35547", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35547" } ] } ] }, { "uniprot_ac": "O60488", "gene_name": "ACSL4", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "O60488", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60488" } ] }, { "ec_number": "6.2.1.15", "activity": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "O60488", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60488" } ] }, { "ec_number": "6.2.1.3", "activity": "", "evidence": [ { "id": "O60488", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60488" } ] } ] }, { "uniprot_ac": "O88561", "gene_name": "Slc27a3", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "O88561", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88561" } ] }, { "ec_number": "6.2.1.-", "activity": "", "evidence": [ { "id": "O88561", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88561" } ] }, { "ec_number": "6.2.1.15", "activity": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "O88561", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88561" } ] } ] }, { "uniprot_ac": "O88813", "gene_name": "Acsl5", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "O88813", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88813" } ] }, { "ec_number": "6.2.1.15", "activity": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "O88813", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88813" } ] }, { "ec_number": "6.2.1.3", "activity": "", "evidence": [ { "id": "O88813", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88813" } ] }, { "ec_number": "6.2.1.15", "activity": "", "evidence": [ { "id": "O88813", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88813" } ] } ] }, { "uniprot_ac": "O95573", "gene_name": "ACSL3", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "O95573", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95573" } ] }, { "ec_number": "6.2.1.2", "activity": "a medium chain fatty acid + ATP + CoA = a medium-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "O95573", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95573" } ] }, { "ec_number": "6.2.1.15", "activity": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "O95573", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95573" } ] } ] }, { "uniprot_ac": "P18163", "gene_name": "Acsl1", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "P18163", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18163" } ] }, { "ec_number": "6.2.1.24", "activity": "3,7,11,15-tetramethylhexadecanoate + ATP + CoA = AMP + diphosphate + phytanoyl-CoA.", "evidence": [ { "id": "P18163", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18163" } ] }, { "ec_number": "6.2.1.15", "activity": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "P18163", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18163" } ] }, { "ec_number": "6.2.1.3", "activity": "", "evidence": [ { "id": "P18163", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18163" } ] }, { "ec_number": "6.2.1.15", "activity": "", "evidence": [ { "id": "P18163", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18163" } ] } ] }, { "uniprot_ac": "P30624", "gene_name": "FAA1", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "P30624", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30624" } ] }, { "ec_number": "6.2.1.3", "activity": "", "evidence": [ { "id": "P30624", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30624" } ] } ] }, { "uniprot_ac": "P33121", "gene_name": "ACSL1", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "P33121", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P33121" } ] }, { "ec_number": "6.2.1.24", "activity": "3,7,11,15-tetramethylhexadecanoate + ATP + CoA = AMP + diphosphate + phytanoyl-CoA.", "evidence": [ { "id": "P33121", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P33121" } ] }, { "ec_number": "6.2.1.15", "activity": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "P33121", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P33121" } ] }, { "ec_number": "6.2.1.3", "activity": "", "evidence": [ { "id": "P33121", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P33121" } ] }, { "ec_number": "6.2.1.15", "activity": "", "evidence": [ { "id": "P33121", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P33121" } ] } ] }, { "uniprot_ac": "P33124", "gene_name": "Acsl6", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "P33124", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P33124" } ] }, { "ec_number": "6.2.1.15", "activity": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "P33124", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P33124" } ] }, { "ec_number": "6.2.1.3", "activity": "", "evidence": [ { "id": "P33124", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P33124" } ] }, { "ec_number": "6.2.1.15", "activity": "", "evidence": [ { "id": "P33124", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P33124" } ] } ] }, { "uniprot_ac": "P38225", "gene_name": "FAT1", "activity": [ { "ec_number": "6.2.1.-", "activity": "", "evidence": [ { "id": "P38225", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P38225" } ] } ] }, { "uniprot_ac": "P39002", "gene_name": "FAA3", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "P39002", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P39002" } ] }, { "ec_number": "6.2.1.3", "activity": "", "evidence": [ { "id": "P39002", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P39002" } ] } ] }, { "uniprot_ac": "P39518", "gene_name": "FAA2", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "P39518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P39518" } ] }, { "ec_number": "6.2.1.3", "activity": "", "evidence": [ { "id": "P39518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P39518" } ] } ] }, { "uniprot_ac": "P41216", "gene_name": "Acsl1", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "P41216", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41216" } ] }, { "ec_number": "6.2.1.24", "activity": "3,7,11,15-tetramethylhexadecanoate + ATP + CoA = AMP + diphosphate + phytanoyl-CoA.", "evidence": [ { "id": "P41216", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41216" } ] }, { "ec_number": "6.2.1.15", "activity": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "P41216", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41216" } ] }, { "ec_number": "6.2.1.3", "activity": "", "evidence": [ { "id": "P41216", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41216" } ] }, { "ec_number": "6.2.1.15", "activity": "", "evidence": [ { "id": "P41216", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41216" } ] } ] }, { "uniprot_ac": "P47912", "gene_name": "FAA4", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "P47912", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47912" } ] }, { "ec_number": "6.2.1.3", "activity": "", "evidence": [ { "id": "P47912", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47912" } ] } ] }, { "uniprot_ac": "P97524", "gene_name": "Slc27a2", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "P97524", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97524" } ] }, { "ec_number": "6.2.1.-", "activity": "", "evidence": [ { "id": "P97524", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97524" } ] }, { "ec_number": "6.2.1.7", "activity": "(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + ATP + CoA = (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "P97524", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97524" } ] }, { "ec_number": "6.2.1.24", "activity": "3,7,11,15-tetramethylhexadecanoate + ATP + CoA = AMP + diphosphate + phytanoyl-CoA.", "evidence": [ { "id": "P97524", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97524" } ] }, { "ec_number": "6.2.1.15", "activity": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "P97524", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97524" } ] } ] }, { "uniprot_ac": "P97849", "gene_name": "Slc27a1", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "P97849", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97849" } ] }, { "ec_number": "6.2.1.-", "activity": "", "evidence": [ { "id": "P97849", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97849" } ] }, { "ec_number": "6.2.1.15", "activity": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "P97849", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97849" } ] } ] }, { "uniprot_ac": "Q08AH1", "gene_name": "ACSM1", "activity": [ { "ec_number": "6.2.1.2", "activity": "a medium chain fatty acid + ATP + CoA = a medium-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q08AH1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q08AH1" } ] }, { "ec_number": "6.2.1.25", "activity": "ATP + benzoate + CoA = AMP + benzoyl-CoA + diphosphate.", "evidence": [ { "id": "Q08AH1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q08AH1" } ] }, { "ec_number": "6.2.1.2", "activity": "", "evidence": [ { "id": "Q08AH1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q08AH1" } ] } ] }, { "uniprot_ac": "Q1ZXQ4", "gene_name": "fcsB", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q1ZXQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q1ZXQ4" } ] }, { "ec_number": "6.2.1.3", "activity": "", "evidence": [ { "id": "Q1ZXQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q1ZXQ4" } ] } ] }, { "uniprot_ac": "Q2XU92", "gene_name": "Acsbg2", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q2XU92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q2XU92" } ] }, { "ec_number": "6.2.1.15", "activity": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q2XU92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q2XU92" } ] }, { "ec_number": "6.2.1.3", "activity": "", "evidence": [ { "id": "Q2XU92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q2XU92" } ] } ] }, { "uniprot_ac": "Q3URE1", "gene_name": "Acsf3", "activity": [ { "ec_number": "6.2.1.76", "activity": "ATP + CoA + malonate = AMP + diphosphate + malonyl-CoA.", "evidence": [ { "id": "Q3URE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3URE1" } ] }, { "ec_number": "6.2.1.76", "activity": "", "evidence": [ { "id": "Q3URE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3URE1" } ] } ] }, { "uniprot_ac": "Q4G176", "gene_name": "ACSF3", "activity": [ { "ec_number": "6.2.1.76", "activity": "ATP + CoA + malonate = AMP + diphosphate + malonyl-CoA.", "evidence": [ { "id": "Q4G176", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4G176" } ] }, { "ec_number": "6.2.1.76", "activity": "", "evidence": [ { "id": "Q4G176", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4G176" } ] } ] }, { "uniprot_ac": "Q4LDG0", "gene_name": "Slc27a5", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q4LDG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4LDG0" } ] }, { "ec_number": "6.2.1.-", "activity": "", "evidence": [ { "id": "Q4LDG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4LDG0" } ] }, { "ec_number": "6.2.1.7", "activity": "(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + ATP + CoA = (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q4LDG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4LDG0" } ] } ] }, { "uniprot_ac": "Q55DR6", "gene_name": "fcsA", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q55DR6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q55DR6" } ] }, { "ec_number": "6.2.1.3", "activity": "", "evidence": [ { "id": "Q55DR6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q55DR6" } ] } ] }, { "uniprot_ac": "Q5FVE4", "gene_name": "ACSBG2", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q5FVE4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5FVE4" } ] }, { "ec_number": "6.2.1.15", "activity": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q5FVE4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5FVE4" } ] }, { "ec_number": "6.2.1.3", "activity": "", "evidence": [ { "id": "Q5FVE4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5FVE4" } ] } ] }, { "uniprot_ac": "Q5K4L6", "gene_name": "SLC27A3", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q5K4L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5K4L6" } ] }, { "ec_number": "6.2.1.-", "activity": "", "evidence": [ { "id": "Q5K4L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5K4L6" } ] }, { "ec_number": "6.2.1.15", "activity": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q5K4L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5K4L6" } ] } ] }, { "uniprot_ac": "Q60714", "gene_name": "Slc27a1", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q60714", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q60714" } ] }, { "ec_number": "6.2.1.-", "activity": "", "evidence": [ { "id": "Q60714", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q60714" } ] }, { "ec_number": "6.2.1.15", "activity": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q60714", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q60714" } ] } ] }, { "uniprot_ac": "Q63151", "gene_name": "Acsl3", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q63151", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63151" } ] }, { "ec_number": "6.2.1.2", "activity": "a medium chain fatty acid + ATP + CoA = a medium-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q63151", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63151" } ] }, { "ec_number": "6.2.1.15", "activity": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q63151", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63151" } ] } ] }, { "uniprot_ac": "Q6P1M0", "gene_name": "SLC27A4", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q6P1M0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6P1M0" } ] }, { "ec_number": "6.2.1.-", "activity": "", "evidence": [ { "id": "Q6P1M0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6P1M0" } ] }, { "ec_number": "6.2.1.15", "activity": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q6P1M0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6P1M0" } ] } ] }, { "uniprot_ac": "Q6PCB7", "gene_name": "SLC27A1", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q6PCB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6PCB7" } ] }, { "ec_number": "6.2.1.-", "activity": "", "evidence": [ { "id": "Q6PCB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6PCB7" } ] }, { "ec_number": "6.2.1.15", "activity": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q6PCB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6PCB7" } ] } ] }, { "uniprot_ac": "Q8JZR0", "gene_name": "Acsl5", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": 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