{
    "uniprot_canonical_ac": "A0JPN2-1",
    "uniprot_ac": "A0JPN2",
    "uniprot_id": "S39A4_RAT",
    "mass": {
        "chemical_mass": 71253.0,
        "monoisotopic_mass": 71253.0
    },
    "refseq": {
        "ac": "NP_001071137",
        "name": "zinc transporter ZIP4 precursor",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071137"
    },
    "gene_names": [
        {
            "name": "Slc39a4",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/A0JPN2",
            "id": "A0JPN2"
        },
        {
            "name": "Zip4",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A0JPN2",
            "id": "A0JPN2"
        }
    ],
    "protein_names": [
        {
            "name": "Zinc transporter ZIP4",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "",
            "id": "A0JPN2"
        },
        {
            "name": "Solute carrier family 39 member 4",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "A0JPN2"
        },
        {
            "name": "ZIP-4",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "A0JPN2"
        },
        {
            "name": "Zrt- and Irt-like protein 4",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "A0JPN2"
        },
        {
            "name": "zinc transporter ZIP4 precursor",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071137",
            "id": "NP_001071137"
        },
        {
            "name": "zinc transporter ZIP4; ZIP-4; zrt- and Irt-like protein 4; solute carrier family 39 (zinc transporter), member 4",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071137",
            "id": "NP_001071137"
        }
    ],
    "function": [
        {
            "annotation": "Chronic alcohol exposure decreases Kruppel-like factor (KLF)4 and ZIP4 expression and consequently decreases zinc transport into cells which, in turn, impairs their function.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001071137",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071137"
                },
                {
                    "database": "PubMed",
                    "id": "23013362",
                    "url": "https://glygen.org/publication/PubMed/23013362"
                }
            ]
        },
        {
            "annotation": "Selective transporter that mediates the uptake of Zn(2+). Plays an essential role for dietary zinc uptake from small intestine (By similarity). The Zn(2+) uniporter activity is regulated by zinc availability. Exhibits also polyspecific binding and transport of Cu(2+), Cd(2+) and possibly Ni(2+) but at higher concentrations (By similarity).",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A0JPN2",
                    "url": "https://www.uniprot.org/uniprot/A0JPN2#function"
                },
                {
                    "database": "UniProtKB",
                    "id": "Q78IQ7",
                    "url": "https://www.uniprot.org/uniprot/Q78IQ7#function"
                },
                {
                    "database": "UniProtKB",
                    "id": "Q6P5W5",
                    "url": "https://www.uniprot.org/uniprot/Q6P5W5#function"
                }
            ]
        },
        {
            "annotation": "The localization of zip1 and zip4 was examined in the brains of adult rats",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001071137",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071137"
                },
                {
                    "database": "PubMed",
                    "id": "19530166",
                    "url": "https://glygen.org/publication/PubMed/19530166"
                }
            ]
        },
        {
            "annotation": "The rapid upregulation of Zip4 expression in the small intestine during zinc deficient conditions corroborates the important role of Zip4 in the systemic control of zinc homeostasis.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001071137",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071137"
                },
                {
                    "database": "PubMed",
                    "id": "26702153",
                    "url": "https://glygen.org/publication/PubMed/26702153"
                }
            ]
        }
    ],
    "disease": [
        {
            "disease_id": "DOID:0050605",
            "recommended_name": {
                "id": "DOID:0050605",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:0050605",
                "name": "acrodermatitis enteropathica",
                "description": "A metal metabolism disorder characterized by dermatitis around bodily openings and the tips of fingers and toes, alopecia and diarrhea and has_material_basis_in mutation in the SLC39A4 gene that encodes a zinc uptake protein and results in zinc deficiency."
            },
            "synonyms": [
                {
                    "id": "MONDO:0008713",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008713",
                    "name": "acrodermatitis enteropathica",
                    "description": "Acrodermatitis enteropathica (AE) is a rare inherited inborn error of metabolism resulting in a severe zinc deficiency and characterized by acral dermatitis, alopecia, diarrhea and growth failure."
                },
                {
                    "id": "MONDO:0008713",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008713",
                    "name": "AEZ",
                    "description": ""
                },
                {
                    "id": "MONDO:0008713",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008713",
                    "name": "acrodermatitis enteropathica",
                    "description": ""
                },
                {
                    "id": "MONDO:0008713",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008713",
                    "name": "acrodermatitis enteropathica, zinc deficiency type",
                    "description": ""
                },
                {
                    "id": "MONDO:0008713",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008713",
                    "name": "inherited zinc deficiency",
                    "description": ""
                },
                {
                    "id": "MONDO:0008713",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008713",
                    "name": "Brandt syndrome",
                    "description": ""
                },
                {
                    "id": "MONDO:0008713",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008713",
                    "name": "Danbolt-Cross syndrome",
                    "description": ""
                },
                {
                    "id": "MONDO:0008713",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008713",
                    "name": "acrodermatitis enteropathica zinc deficiency type",
                    "description": ""
                },
                {
                    "id": "MONDO:0008713",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008713",
                    "name": "acrodermatitis enteropathica, zinc-deficiency type",
                    "description": ""
                },
                {
                    "id": "MONDO:0008713",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008713",
                    "name": "ae",
                    "description": ""
                },
                {
                    "id": "MONDO:0008713",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008713",
                    "name": "enteropathica",
                    "description": ""
                },
                {
                    "id": "MIM:201100",
                    "resource": "MIM",
                    "url": "https://www.omim.org/entry/201100",
                    "name": "Acrodermatitis enteropathica, zinc-deficiency type",
                    "description": "Acrodermatitis enteropathica, zinc-deficiency type"
                }
            ],
            "evidence": [
                {
                    "id": "0050605",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050605"
                }
            ]
        }
    ],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Rattus norvegicus",
            "taxid": 10116,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A0JPN2",
                    "url": "https://www.uniprot.org/uniprot/A0JPN2"
                }
            ],
            "common_name": "Rat"
        }
    ],
    "gene": [
        {
            "name": "Slc39a4",
            "url": "https://www.uniprot.org/uniprot/A0JPN2",
            "locus": {
                "chromosome": "7",
                "start_pos": 108333381,
                "end_pos": 108337553,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSRNOG00000014314",
                        "url": "https://www.ensembl.org/id/ENSRNOG00000014314"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSRNOG00000014314",
            "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000014314",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "300051",
            "url": "https://www.ncbi.nlm.nih.gov/gene/300051",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "IPR003689",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR003689",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR041137",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR041137",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "rno:300051",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:300051",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "TCVEVPQ",
            "url": "https://omabrowser.org/oma/group/TCVEVPQ/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "5488029at2759",
            "url": "http://www.orthodb.org/?query=5488029at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR12191",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12191",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR12191:SF21",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12191:SF21",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF02535",
            "url": "http://pfam.xfam.org/family/PF02535",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF18292",
            "url": "http://pfam.xfam.org/family/PF18292",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PR_A0JPN2",
            "url": "http://purl.obolibrary.org/obo/PR_A0JPN2",
            "database": "PRO",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "R-RNO-442380",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-442380",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "NP_001071137",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071137",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "1306701",
            "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1306701",
            "database": "RGD",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "29351",
            "url": "https://www.rhea-db.org/rhea/29351",
            "database": "Rhea",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "A0A0H2UHY4",
            "url": "https://www.uniprot.org/uniprot/A0A0H2UHY4",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A0H2UHY4-1",
            "url": "https://www.uniprot.org/uniprot/A0A0H2UHY4-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0JPN2",
            "url": "https://www.uniprot.org/uniprot/A0JPN2",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0JPN2-1",
            "url": "https://www.uniprot.org/uniprot/A0JPN2-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "M0RAL0",
            "url": "https://www.uniprot.org/uniprot/M0RAL0",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "M0RAL0-1",
            "url": "https://www.uniprot.org/uniprot/M0RAL0-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MMLPKSLTQGLLLAMLVGTAAMVQPYHLLSLLTSGQGALDRTALDGLLNTLVARVHCTDGPCEKCLSVETALALGKPDKPQLAPESVLESRYITYLSAAAALYLNDPEKTCKDIRAGLLASHVDDYLAKLESPEAMTLGLSQLLQKIEAHDASQPTREETCVDVPQLLEEAEEAGVSRSPGLVLTALLDHVLNGSCFQGLPSPQYFVDFVFRQLSSKPRNITLPELEDLMHHLGVGGEDHSDHGDHVDHSHLDREANHQDSELHATHNSSSSVWDTLCLSAKDVMAVYGLSEEAGVSPQAWAQLTPALVQQQLSEACSSSPIIHVQDQLSQAERYLYGSLATLLICLCAVFGLLLLTCAKCSTATHYIMQTFLSLAVGALTGDALLHLIPKVLGLHTHSGEVHSHEEESIGGQSTWRLLAVLGGFYIFFLFESFFNLLLPRDQDHEKDGPCSHGGHSHGISLQLSPSNLRQSKQPHESSRSDLVTEETPELLNPDTRRLRAELRMLPYLITLGDAVHNFADGLAVGAAFSSTWKTGLATSLAVFCHELPHELGDFAALLHAGLTVKRALLLNLASALTAFAGLYVALAVGVGEEGETWILAVATGLFLYVALCDMLPAMMNVRDQRPWLLFLLHNVGLLGGWTILLLLSLYEDSITF",
        "length": 657,
        "header": "sp|A0JPN2-1|S39A4_RAT Isoform 1 of Zinc transporter ZIP4  OS=Rattus norvegicus OX=10116 GN=Slc39a4 PE=2 SV=2 CANONICAL=A0JPN2-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A0A0H2UHY4-1",
            "url": "",
            "sequence": {
                "sequence": "MMLPKSLTQGLLLAMLVGTAAMVQPYHLLSLLTSGQGALDRTALDGLLNTLVARVHCTDGPCEKCLSVETALALGKPDKPQLAPESVLESRYITYLSAAAALYLNDPEKTCKDIRAGLLASHVDDYLAKLESPEAMTLGLSQLLQKIEAHDASQPTREETCVDVPQLLEEAEEAGVSRSPGLVLTALLDHVLNGSCFQGLPSPQYFVDFVFRQLSSKPRNITLPELEDLMHHLGVGGEDHSDHGDHVDHSHLDREANHQDSELHATHNSSSSVWDTLCLSAKDVMAVYGLSEEAGVSPQAWAQLTPALVQQQLSEACSSSPIIHVQDQLSQAERYLYGSLATLLICLCAVFGLLLLTCAKCSTATHYIMQTFLSLAVGALTGDALLHLIPKVLGLHTHSGEVHSHEEESIGGQSTWRLLAVLGGFYIFFLFESFFNLLLPRDQDHEKDGPCSHGGHSHGISLQLSPSNLRQSKQPHESSRSDLVTEETPELLNPDTRRLRAELRMLPYLITLGDAVHNFADGLAVGAAFSSTWKTGLATSLAVFCHELPHELGDFAALLHAGLTVKRALLLNLASALTAFAGLYVALAVGVGEEGETWILAVATGLFLYVALCDMLPAMMNVRDQRPWLLFLLHNVGLLGGWTILLLLSLYEDSITF",
                "length": 657,
                "header": "tr|A0A0H2UHY4-1|S39A4_RAT Computationally mapped isoform of Zinc transporter ZIP4  OS=Rattus norvegicus OX=10116 GN=Slc39a4 PE=2 SV=1 CANONICAL=A0JPN2-1"
            },
            "locus": {
                "chromosome": "7",
                "start_pos": 108337461,
                "end_pos": 108333531,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000040422.6",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000040422.6"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000047376.4",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000047376.4"
                    }
                ]
            }
        },
        {
            "isoform_ac": "A0JPN2-1",
            "url": "",
            "sequence": {
                "sequence": "MMLPKSLTQGLLLAMLVGTAAMVQPYHLLSLLTSGQGALDRTALDGLLNTLVARVHCTDGPCEKCLSVETALALGKPDKPQLAPESVLESRYITYLSAAAALYLNDPEKTCKDIRAGLLASHVDDYLAKLESPEAMTLGLSQLLQKIEAHDASQPTREETCVDVPQLLEEAEEAGVSRSPGLVLTALLDHVLNGSCFQGLPSPQYFVDFVFRQLSSKPRNITLPELEDLMHHLGVGGEDHSDHGDHVDHSHLDREANHQDSELHATHNSSSSVWDTLCLSAKDVMAVYGLSEEAGVSPQAWAQLTPALVQQQLSEACSSSPIIHVQDQLSQAERYLYGSLATLLICLCAVFGLLLLTCAKCSTATHYIMQTFLSLAVGALTGDALLHLIPKVLGLHTHSGEVHSHEEESIGGQSTWRLLAVLGGFYIFFLFESFFNLLLPRDQDHEKDGPCSHGGHSHGISLQLSPSNLRQSKQPHESSRSDLVTEETPELLNPDTRRLRAELRMLPYLITLGDAVHNFADGLAVGAAFSSTWKTGLATSLAVFCHELPHELGDFAALLHAGLTVKRALLLNLASALTAFAGLYVALAVGVGEEGETWILAVATGLFLYVALCDMLPAMMNVRDQRPWLLFLLHNVGLLGGWTILLLLSLYEDSITF",
                "length": 657,
                "header": "sp|A0JPN2-1|S39A4_RAT Isoform 1 of Zinc transporter ZIP4  OS=Rattus norvegicus OX=10116 GN=Slc39a4 PE=2 SV=2 CANONICAL=A0JPN2-1"
            },
            "locus": {}
        },
        {
            "isoform_ac": "M0RAL0-1",
            "url": "",
            "sequence": {
                "sequence": "MLPKSLTQGLLLAMLVGTAAMVQPYHLLSLLTSGQGALDRTALDGLLNTLVARVHCTDGPCEKCLSVETALALGKPDKPQLAPESVLESRYITYLSAAAALYLNDPEKTCKDIRAGLLASHVDDYLAKLESPEAMTLGLSQLLQKIEAHDASQPTREETCVDVPQLLEEAEEAGVSRSPGLVLTALLDHVLNGSCFQGLPSPQYFVDFVFRQLSSKPRNITLPELEDLMHHLGVGGEDHSDHGDHVDHSHLDREANHQDSELHATHNSSSSVWDTLCLSAKDVMAVYGLSEEAGVSPQAWAQLTPALVQQQLSEACSSSPIIHVQDQLSQAERYLYGSLATLLICLCAVFGLLLLTCAKCSTATHYIMQTFLSLAVGALTGDALLHLIPKDHEKDGPCSHGGHSHGISLQLSPSNLRQSKQPHESSRSDLVTEETPELLNPDTRRLRAELRMLPYLITLGDAVHNFADGLAVGAAFSSTWKTGLATSLAVFCHELPHELGDFAALLHAGLTVKRALLLNLASALTAFAGLYVALAVGVGEEGETWILAVATGLFLYVALCDMLPAMMNVRDQRPWLLFLLHNVGLLGGWTILLLLSLYEDSITF",
                "length": 604,
                "header": "tr|M0RAL0-1|M0RAL0_RAT Computationally mapped isoform of Solute carrier family 39 member 4  OS=Rattus norvegicus OX=10116 GN=Slc39a4 PE=3 SV=3 CANONICAL=A0JPN2-1"
            },
            "locus": {
                "chromosome": "7",
                "start_pos": 108337458,
                "end_pos": 108333531,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000071522.3",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000071522.3"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000066561.3",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000066561.3"
                    }
                ]
            }
        }
    ],
    "glycosylation": [
        {
            "glytoucan_ac": "",
            "type": "N-linked",
            "subtype": "",
            "site_category": "predicted",
            "site_seq": "N",
            "relation": "attached",
            "comment": "N-linked (GlcNAc...) asparagine",
            "start_pos": 193,
            "start_aa": "Asn",
            "end_pos": 193,
            "end_aa": "Asn",
            "residue": "Asn",
            "site_lbl": "Asn193",
            "evidence": [
                {
                    "id": "A0JPN2",
                    "database": "UniProtKB",
                    "url": "https://www.uniprot.org/uniprot/A0JPN2#ptm_processing"
                }
            ]
        },
        {
            "glytoucan_ac": "",
            "type": "N-linked",
            "subtype": "",
            "site_category": "predicted",
            "site_seq": "N",
            "relation": "attached",
            "comment": "N-linked (GlcNAc...) asparagine",
            "start_pos": 220,
            "start_aa": "Asn",
            "end_pos": 220,
            "end_aa": "Asn",
            "residue": "Asn",
            "site_lbl": "Asn220",
            "evidence": [
                {
                    "id": "A0JPN2",
                    "database": "UniProtKB",
                    "url": "https://www.uniprot.org/uniprot/A0JPN2#ptm_processing"
                }
            ]
        },
        {
            "glytoucan_ac": "",
            "type": "N-linked",
            "subtype": "",
            "site_category": "predicted",
            "site_seq": "N",
            "relation": "attached",
            "comment": "N-linked (GlcNAc...) asparagine",
            "start_pos": 268,
            "start_aa": "Asn",
            "end_pos": 268,
            "end_aa": "Asn",
            "residue": "Asn",
            "site_lbl": "Asn268",
            "evidence": [
                {
                    "id": "A0JPN2",
                    "database": "UniProtKB",
                    "url": "https://www.uniprot.org/uniprot/A0JPN2#ptm_processing"
                }
            ]
        }
    ],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [
        "glycoprotein",
        "glycoprotein_predicted"
    ],
    "publication": [
        {
            "title": "Localization of zip1 and zip4 mRNA in the adult rat brain.",
            "journal": "Journal of neuroscience research",
            "date": "2009",
            "authors": "Belloni-Olivi L, Marshall C, Laal B, Andrews GK, Bressler J",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001071137",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071137"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "19530166",
                    "url": "https://glygen.org/publication/PubMed/19530166"
                }
            ]
        },
        {
            "title": "A systems biology approach for the investigation of the heparin/heparan sulfate interactome.",
            "journal": "The Journal of biological chemistry",
            "date": "2011",
            "authors": "Ori A, Wilkinson MC, Fernig DG",
            "evidence": [
                {
                    "database": "MatrixDB",
                    "id": "GAG_1",
                    "url": "http://matrixdb.univ-lyon1.fr/cgi-bin/current/newPort?type=biomolecule&value=GAG_1"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "21454685",
                    "url": "https://glygen.org/publication/PubMed/21454685"
                }
            ]
        },
        {
            "title": "In vitro study on the transport of zinc across intestinal epithelial cells using Caco-2 monolayers and isolated rat intestinal membranes.",
            "journal": "Biol. Pharm. Bull.",
            "date": "2012",
            "authors": "Yamamoto T., Yoshikawa Y., Yamamoto A., Kimura S., Nagai M., Okamoto H., Nagano K., Yasui H., Sakane T., Yasuno T., Furubayashi T., Katsumi H.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A0JPN2",
                    "url": "https://www.uniprot.org/uniprot/A0JPN2"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "22466565",
                    "url": "https://glygen.org/publication/PubMed/22466565"
                }
            ]
        },
        {
            "title": "Chronic alcohol ingestion in rats decreases Kruppel-like factor 4 expression and intracellular zinc in the lung.",
            "journal": "Alcoholism, clinical and experimental research",
            "date": "2013",
            "authors": "Curry-McCoy TV, Guidot DM, Joshi PC",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001071137",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071137"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "23013362",
                    "url": "https://glygen.org/publication/PubMed/23013362"
                }
            ]
        },
        {
            "title": "Properties of Zip4 accumulation during zinc deficiency and its usefulness to evaluate zinc status: a study of the effects of zinc deficiency during lactation.",
            "journal": "American journal of physiology. Regulatory, integrative and comparative physiology",
            "date": "2016",
            "authors": "Hashimoto A, Nakagawa M, Tsujimura N, Miyazaki S, Kizu K, Goto T, Komatsu Y, Matsunaga A, Shirakawa H, Narita H, Kambe T, Komai M",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001071137",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071137"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "26702153",
                    "url": "https://glygen.org/publication/PubMed/26702153"
                }
            ]
        }
    ],
    "pathway": [
        {
            "id": "rno:300051",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:300051",
            "resource": "KEGG Pathway"
        },
        {
            "id": "R-RNO-442380",
            "name": "Zinc influx into cells by the SLC39 gene family",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-442380",
            "resource": "Reactome",
            "description": "Zinc influx into cells by the SLC39 gene family"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "Q6P5W5-1",
            "protein_name": "Zinc transporter ZIP4",
            "gene_name": "SLC39A4",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MASLVSLELGLLLAVLVVTATASPPAGLLSLLTSGQGALDQEALGGLLNTLADRVHCANGPCGKCLSVEDALGLGEPEGSGLPPGPVLEARYVARLSAAAVLYLSNPEGTCEDARAGLWASHADHLLALLESPKALTPGLSWLLQRMQARAAGQTPKMACVDIPQLLEEAVGAGAPGSAGGVLAALLDHVRSGSCFHALPSPQYFVDFVFQQHSSEVPMTLAELSALMQRLGVGREAHSDHSHRHRGASSRDPVPLISSSNSSSVWDTVCLSARDVMAAYGLSEQAGVTPEAWAQLSPALLQQQLSGACTSQSRPPVQDQLSQSERYLYGSLATLLICLCAVFGLLLLTCTGCRGVTHYILQTFLSLAVGAVTGDAVLHLTPKVLGLHTHSEEGLSPQPTWRLLAMLAGLYAFFLFENLFNLLLPRDPEDLEDGPCGHSSHSHGGHSHGVSLQLAPSELRQPKPPHEGSRADLVAEESPELLNPEPRRLSPELRLLPYMITLGDAVHNFADGLAVGAAFASSWKTGLATSLAVFCHELPHELGDFAALLHAGLSVRQALLLNLASALTAFAGLYVALAVGVSEESEAWILAVATGLFLYVALCDMLPAMLKVRDPRPWLLFLLHNVGLLGGWTVLLLLSLYEDDITF",
                "length": 647
            },
            "evidence": [
                {
                    "id": "45233951",
                    "url": "http://www.informatics.jax.org/homology/45233951",
                    "database": "MGI"
                }
            ],
            "common_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q78IQ7-1",
            "protein_name": "Zinc transporter ZIP4",
            "gene_name": "Slc39a4",
            "tax_id": 10090,
            "organism": "Mus musculus",
            "sequence": {
                "sequence": "MLPKSVTQGLVLALLVGTVAVARPRNLLSLLALGQGALDRLELDGLLNTLVARVHCTDGPCEKCLSVENVLALGKPDKPQPAPESVLESRHIIYLSAAAALYLNNPEKTCKDIQAGLLASHVDDYLATLESPEAMTLGLSQLLQKIEAHAASQPTGEKTCVDLPQLLEEAEAAGVSKSAGLVLTALLDHVINGSCFQGLPSPQYFVDFVFRLHSSDPPNITLHELENLMHHLGVGGEDHSDHDDHGDHADHSHPDRKASHQDSELHTPHNSNSSVWDTLCLSAKDIMAVYGLSEEAGVSPQAWAQLTPALVQQQLSGACSPYPTIRIQDQLSQTERYLYGSLATLLICLCAVFGLLLLTCAKCSTATHYIMQTFLSLAVGALTGDALLHLIPKVLGLHTHGGEGHTHEEEVGVGGQATWRLLAVLGGFYIFFLFESFFNLLLPRDQDSEKDGPCSHGGHSHGISLQLAPSNLRQSKQTHESSRSDLVAEETPELLNPETRRLRAELRLLPYLITLGDAVHNFADGLAVGAAFSSSWKTGLATSLAVFCHELPHELGDFAALLHAGLSVKRALLLNLASALTAFAGLYVALAVGVGEEGEAWILAVATGLFLYVALCDMLPAMMNVRDQRPWLLFLLHNVGLLGGWTVLLLLSLYEDNITF",
                "length": 660
            },
            "evidence": [
                {
                    "id": "45233951",
                    "url": "http://www.informatics.jax.org/homology/45233951",
                    "database": "MGI"
                }
            ],
            "common_name": "Mouse"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Molecular Function",
                "total": 8,
                "go_terms": [
                    {
                        "name": "zinc ion transmembrane transporter activity",
                        "id": "GO:0005385",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005385",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0JPN2",
                                "url": "https://www.uniprot.org/uniprot/A0JPN2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "identical protein binding",
                        "id": "GO:0042802",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0JPN2",
                                "url": "https://www.uniprot.org/uniprot/A0JPN2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "zinc ion sensor activity",
                        "id": "GO:0106219",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0106219",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0JPN2",
                                "url": "https://www.uniprot.org/uniprot/A0JPN2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "zinc ion sequestering activity",
                        "id": "GO:0140486",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140486",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0JPN2",
                                "url": "https://www.uniprot.org/uniprot/A0JPN2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "zinc ion binding",
                        "id": "GO:0008270",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0JPN2",
                                "url": "https://www.uniprot.org/uniprot/A0JPN2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "metal ion binding",
                        "id": "GO:0046872",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0JPN2",
                                "url": "https://www.uniprot.org/uniprot/A0JPN2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "monoatomic cation:bicarbonate symporter activity",
                        "id": "GO:0140410",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140410",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0JPN2",
                                "url": "https://www.uniprot.org/uniprot/A0JPN2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "metal ion transmembrane transporter activity",
                        "id": "GO:0046873",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046873",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0JPN2",
                                "url": "https://www.uniprot.org/uniprot/A0JPN2"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Cellular Component",
                "total": 5,
                "go_terms": [
                    {
                        "name": "apical plasma membrane",
                        "id": "GO:0016324",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016324",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0JPN2",
                                "url": "https://www.uniprot.org/uniprot/A0JPN2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "recycling endosome membrane",
                        "id": "GO:0055038",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055038",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0JPN2",
                                "url": "https://www.uniprot.org/uniprot/A0JPN2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "plasma membrane",
                        "id": "GO:0005886",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0JPN2",
                                "url": "https://www.uniprot.org/uniprot/A0JPN2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cytoplasmic vesicle",
                        "id": "GO:0031410",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031410",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0JPN2",
                                "url": "https://www.uniprot.org/uniprot/A0JPN2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "membrane",
                        "id": "GO:0016020",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0JPN2",
                                "url": "https://www.uniprot.org/uniprot/A0JPN2"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Biological Process",
                "total": 3,
                "go_terms": [
                    {
                        "name": "intracellular zinc ion homeostasis",
                        "id": "GO:0006882",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006882",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0JPN2",
                                "url": "https://www.uniprot.org/uniprot/A0JPN2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cellular response to zinc ion starvation",
                        "id": "GO:0034224",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034224",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0JPN2",
                                "url": "https://www.uniprot.org/uniprot/A0JPN2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "zinc ion transmembrane transport",
                        "id": "GO:0071577",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071577",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0JPN2",
                                "url": "https://www.uniprot.org/uniprot/A0JPN2"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            }
        ]
    },
    "pro_annotation": [],
    "site_annotation": [
        {
            "start_pos": 193,
            "end_pos": 195,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 220,
            "end_pos": 222,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 268,
            "end_pos": 270,
            "annotation": "n_glycosylation_sequon"
        }
    ],
    "ptm_annotation": [
        {
            "annotation": "Glycosylated.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A0JPN2",
                    "url": "https://www.uniprot.org/uniprot/A0JPN2"
                },
                {
                    "database": "PubMed",
                    "id": "Q6P5W5",
                    "url": "https://glygen.org/publication/PubMed/Q6P5W5"
                }
            ]
        },
        {
            "annotation": "The extracellular N-terminal ectodomain is cleaved when cells are Zn(2+) deficient, N-terminally cleaved SLC39A4 is internalized at a faster rate.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A0JPN2",
                    "url": "https://www.uniprot.org/uniprot/A0JPN2"
                },
                {
                    "database": "PubMed",
                    "id": "Q78IQ7",
                    "url": "https://glygen.org/publication/PubMed/Q78IQ7"
                }
            ]
        },
        {
            "annotation": "Under excess Zn(2+) conditions, SLC39A4 on the cell surface is rapidly endocytosed, ubiquitinated and degraded.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A0JPN2",
                    "url": "https://www.uniprot.org/uniprot/A0JPN2"
                },
                {
                    "database": "PubMed",
                    "id": "Q6P5W5",
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                }
            ]
        }
    ],
    "interactions": [],
    "reactions": [
        {
            "id": "29351",
            "name": "",
            "equation": "Zn(2+)(in) = Zn(2+)(out)",
            "summary": "",
            "cellular_location": "",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [],
            "evidence": [
                {
                    "id": "29351",
                    "database": "Rhea",
                    "url": "https://www.rhea-db.org/rhea/29351"
                }
            ]
        }
    ],
    "reaction_participants": [],
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    "biomarkers": [],
    "synthesized_glycans": [],
    "cluster_types": [
        {
            "name": "isoformset.uniprotkb",
            "label": "Isoforms"
        },
        {
            "name": "homologset.mgi",
            "label": "MGI Homologs"
        }
    ],
    "section_stats": [
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}