{ "uniprot_canonical_ac": "A0A8I6AL52-1", "uniprot_ac": "A0A8I6AL52", "uniprot_id": "A0A8I6AL52_RAT", "mass": { "chemical_mass": 32345.0, "monoisotopic_mass": 32345.0 }, "refseq": {}, "gene_names": [ { "name": "ENSRNOG00000067141", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A0A8I6AL52", "id": "A0A8I6AL52" } ], "protein_names": [ { "name": "[histone H4]-lysine(20) N-methyltransferase", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "A0A8I6AL52" }, { "name": "2.1.1.361", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "A0A8I6AL52" } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "A0A8I6AL52", "url": "https://www.uniprot.org/uniprot/A0A8I6AL52" } ], "common_name": "Rat" } ], "gene": [ { "name": "ENSRNOG00000067141", "url": "https://www.uniprot.org/uniprot/A0A8I6AL52", "locus": {} } ], "crossref": [ { "id": "cd10528", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd10528", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001214", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001214", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016858", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016858", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046341", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046341", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047266", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047266", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PISHSKC", "url": "https://omabrowser.org/oma/group/PISHSKC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR46167", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46167", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46167:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46167:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00856", "url": "http://pfam.xfam.org/family/PF00856", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "150343506", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=150343506", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "51736", "url": "https://www.rhea-db.org/rhea/51736", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "60344", "url": "https://www.rhea-db.org/rhea/60344", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A8I6AL52", "url": "https://www.uniprot.org/uniprot/A0A8I6AL52", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6AL52-1", "url": "https://www.uniprot.org/uniprot/A0A8I6AL52-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MENRWSPNKCSGMRSPLQEENSVAQHEVKCLGKPLAGIYRKREEKRNAGNVIRSAVKGPLAPFPNQKSEATEPPKTPPPSCDSTSVAVAKQALKKPLKGKQAPREKSQGKTQQNRKLTDFYPVRRSSRKSKAELRSEERKKTDELIESGKEEGIKIDLIDGKGRGVIATKRFSRGDFVVEYHGDLIEITDARKREALYAQDPSTGCYMYYFQYLSKTYCVDATQETNLLGRLINHSKCGNCQTKLHDIDGVPHLILIASGDIAAGEELLYDYGDWSKASIEAYPWLKH", "length": 288, "header": "tr|A0A8I6AL52-1|A0A8I6AL52_RAT Isoform 1 of [histone H4]-lysine(20) N-methyltransferase OS=Rattus norvegicus OX=10116 GN=ENSRNOG00000067141 PE=4 SV=1 CANONICAL=A0A8I6AL52-1" }, "isoforms": [ { "isoform_ac": "A0A8I6AL52-1", "url": "", "sequence": { "sequence": "MENRWSPNKCSGMRSPLQEENSVAQHEVKCLGKPLAGIYRKREEKRNAGNVIRSAVKGPLAPFPNQKSEATEPPKTPPPSCDSTSVAVAKQALKKPLKGKQAPREKSQGKTQQNRKLTDFYPVRRSSRKSKAELRSEERKKTDELIESGKEEGIKIDLIDGKGRGVIATKRFSRGDFVVEYHGDLIEITDARKREALYAQDPSTGCYMYYFQYLSKTYCVDATQETNLLGRLINHSKCGNCQTKLHDIDGVPHLILIASGDIAAGEELLYDYGDWSKASIEAYPWLKH", "length": 288, "header": "tr|A0A8I6AL52-1|A0A8I6AL52_RAT Isoform 1 of [histone H4]-lysine(20) N-methyltransferase OS=Rattus norvegicus OX=10116 GN=ENSRNOG00000067141 PE=4 SV=1 CANONICAL=A0A8I6AL52-1" }, "locus": { "chromosome": "10", "start_pos": 31087918, "end_pos": 31086733, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000107677.1", "url": "https://www.ensembl.org/id/ENSRNOT00000107677.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000093816.1", "url": "https://www.ensembl.org/id/ENSRNOP00000093816.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0A8I6AL52", "url": "https://www.uniprot.org/uniprot/A0A8I6AL52" } ], "pmid": "" }, { "name": "chromosome", "id": "GO:0005694", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005694", "evidence": [ { "database": "UniProtKB", "id": "A0A8I6AL52", "url": "https://www.uniprot.org/uniprot/A0A8I6AL52" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "histone H4K20 methyltransferase activity", "id": "GO:0042799", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042799", "evidence": [ { "database": "UniProtKB", "id": "A0A8I6AL52", "url": "https://www.uniprot.org/uniprot/A0A8I6AL52" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 234, "end_pos": 236, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "51736", "name": "", "equation": "L-lysyl-[protein] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P0C6Y7-1", "D3ZSK5-1", "Q7M6Z3-1", "A0A0G2JTW4-1", "A0A0G2JW37-1", "D3ZEB9-1", "M0R767-1", "D4ADE5-1", "A0A8I6AL52-1", "Q8N6R0-5", "Q9NQV7-1", "Q9BYW2-1", "P0DPD7-4", "Q9NQR1-1", "Q9NRG4-1", "Q96AZ1-1", "Q8TBK2-1", "Q8WTS6-1", "Q91YR5-3", "Q96EQ9-1", "E9Q5F9-1", "P0DPE0-1", "D3YWP0-1", "Q9CWY3-1", "Q2YDW7-1", "Q8R5A0-1", "Q8VHL1-1", "Q54J80-1", "Q9VIK9-1" ], "evidence": [ { "id": "51736", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/51736" } ] }, { "id": "60344", "name": "", "equation": "L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P0C2N5-1", "P0C6Y7-1", "P0C2N6-1", "A0A0G2JTW4-1", "A0A0G2JW37-1", "D3ZEB9-1", "M0R767-1", "A0A8I6AL52-1", "Q9NVD3-1", "Q4FZB7-1", "Q9NQR1-1", "Q86Y97-1", "Q9NQX0-3", "Q9NQV7-1", "Q3U8K7-1", "P58467-1", "Q2YDW7-1", "Q6Q783-1", "Q3UZD5-1", "Q96EQ9-1", "Q9VFK6-1", "Q9W5E0-1" ], "evidence": [ { "id": "60344", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/60344" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A0G2JTW4", "gene_name": "AABR07010705.1", "activity": [ { "ec_number": "2.1.1.361", "activity": "L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine.", "evidence": [ { "id": "A0A0G2JTW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2JTW4" } ] }, { "ec_number": "2.1.1.361", "activity": "", "evidence": [ { "id": "A0A0G2JTW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2JTW4" } ] } ] }, { "uniprot_ac": "A0A0G2JW37", "gene_name": "RGD1561318", "activity": [ { "ec_number": "2.1.1.361", "activity": "L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine.", "evidence": [ { "id": "A0A0G2JW37", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2JW37" } ] }, { "ec_number": "2.1.1.361", "activity": "", "evidence": [ { "id": "A0A0G2JW37", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2JW37" } ] } ] }, { "uniprot_ac": "A0A8I6AL52", "gene_name": "ENSRNOG00000067141", "activity": [ { "ec_number": "2.1.1.361", "activity": "L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine.", "evidence": [ { "id": "A0A8I6AL52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6AL52" } ] }, { "ec_number": "2.1.1.361", "activity": "", "evidence": [ { "id": "A0A8I6AL52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6AL52" } ] } ] }, { "uniprot_ac": "D3YWP0", "gene_name": "Eef1akmt3", "activity": [ { "ec_number": "2.1.1.-", "activity": "", "evidence": [ { "id": "D3YWP0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3YWP0" } ] } ] }, { "uniprot_ac": "D3ZEB9", "gene_name": "Kmt5a", "activity": [ { "ec_number": "2.1.1.361", "activity": "L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine.", "evidence": [ { "id": "D3ZEB9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZEB9" } ] }, { "ec_number": "2.1.1.361", "activity": "", "evidence": [ { "id": "D3ZEB9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZEB9" } ] } ] }, { "uniprot_ac": "D3ZSK5", "gene_name": "Setd6", "activity": [ { "ec_number": "2.1.1.-", "activity": "", "evidence": [ { "id": "D3ZSK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZSK5" } ] } ] }, { "uniprot_ac": "D4ADE5", "gene_name": "Setd7", "activity": [ { "ec_number": "2.1.1.364", "activity": "L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine.", "evidence": [ { "id": "D4ADE5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4ADE5" } ] }, { "ec_number": "2.1.1.364", "activity": "", "evidence": [ { "id": "D4ADE5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4ADE5" } ] }, { "ec_number": "2.1.1.-", "activity": "", "evidence": [ { "id": "D4ADE5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4ADE5" } ] } ] }, { "uniprot_ac": "E9Q5F9", "gene_name": "Setd2", "activity": [ { "ec_number": "2.1.1.359", "activity": "L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-homocysteine.", "evidence": [ { "id": "E9Q5F9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9Q5F9" } ] }, { "ec_number": "2.1.1.-", "activity": "", "evidence": [ { "id": "E9Q5F9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9Q5F9" } ] }, { "ec_number": "2.1.1.359", "activity": "", "evidence": [ { "id": "E9Q5F9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9Q5F9" } ] } ] }, { "uniprot_ac": "M0R767", "gene_name": "AABR07033047.1", "activity": [ { "ec_number": "2.1.1.361", "activity": "L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine.", "evidence": [ { "id": "M0R767", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/M0R767" } ] }, { "ec_number": "2.1.1.361", "activity": "", "evidence": [ { "id": "M0R767", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/M0R767" } ] } ] }, { "uniprot_ac": "P0C2N5", "gene_name": "Kmt5b", "activity": [ { "ec_number": "2.1.1.362", "activity": "N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = H(+) + N(6),N(6)-dimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine.", "evidence": [ { "id": "P0C2N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C2N5" } ] }, { "ec_number": "2.1.1.361", "activity": "L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine.", "evidence": [ { "id": "P0C2N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C2N5" } ] }, { "ec_number": "2.1.1.361", "activity": "", "evidence": [ { "id": "P0C2N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C2N5" } ] }, { "ec_number": "2.1.1.362", "activity": "", "evidence": [ { "id": "P0C2N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C2N5" } ] } ] }, { "uniprot_ac": "P0C2N6", "gene_name": "Kmt5c", "activity": [ { "ec_number": "2.1.1.362", "activity": "N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = H(+) + N(6),N(6)-dimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine.", "evidence": [ { "id": "P0C2N6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C2N6" } ] }, { "ec_number": "2.1.1.361", "activity": "L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine.", "evidence": [ { "id": "P0C2N6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C2N6" } ] }, { "ec_number": "2.1.1.362", "activity": "", "evidence": [ { "id": "P0C2N6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C2N6" } ] } ] }, { "uniprot_ac": "P0C6Y7", "gene_name": "Prdm9", "activity": [ { "ec_number": "2.1.1.359", "activity": "L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-homocysteine.", "evidence": [ { "id": "P0C6Y7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C6Y7" } ] }, { "ec_number": "2.1.1.-", "activity": "", "evidence": [ { "id": "P0C6Y7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C6Y7" } ] }, { "ec_number": "2.1.1.355", "activity": "L-lysyl(9)-[histone H3] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 3 S-adenosyl-L-homocysteine.", "evidence": [ { "id": "P0C6Y7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C6Y7" } ] }, { "ec_number": "2.1.1.354", "activity": "L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-homocysteine.", "evidence": [ { "id": "P0C6Y7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C6Y7" } ] }, { "ec_number": "2.1.1.362", "activity": "N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = H(+) + N(6),N(6)-dimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine.", "evidence": [ { "id": "P0C6Y7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C6Y7" } ] }, { "ec_number": "2.1.1.361", "activity": "L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine.", "evidence": [ { "id": "P0C6Y7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C6Y7" } ] } ] }, { "uniprot_ac": "P0DPD7", "gene_name": "EEF1AKMT4", "activity": [ { "ec_number": "2.1.1.-", "activity": "", "evidence": [ { "id": "P0DPD7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0DPD7" } ] } ] }, { "uniprot_ac": "P0DPE0", "gene_name": "Eef1akmt4", "activity": [ { "ec_number": "2.1.1.-", "activity": "", "evidence": [ { "id": "P0DPE0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0DPE0" } ] } ] }, { "uniprot_ac": "P58467", "gene_name": "Setd4", "activity": [ { "ec_number": "2.1.1.-", "activity": "", "evidence": [ { "id": "P58467", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P58467" } ] }, { "ec_number": "2.1.1.364", "activity": "L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine.", "evidence": [ { "id": "P58467", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P58467" } ] }, { "ec_number": "2.1.1.364", "activity": "", "evidence": [ { "id": "P58467", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P58467" } ] } ] }, { "uniprot_ac": "Q2YDW7", "gene_name": "Kmt5a", "activity": [ { "ec_number": "2.1.1.361", "activity": "L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine.", "evidence": [ { "id": "Q2YDW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q2YDW7" } ] }, { "ec_number": "2.1.1.361", "activity": "", "evidence": [ { "id": "Q2YDW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q2YDW7" } ] }, { "ec_number": "2.1.1.-", "activity": "", "evidence": [ { "id": "Q2YDW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q2YDW7" } ] } ] }, { "uniprot_ac": "Q3U8K7", "gene_name": "Kmt5b", "activity": [ { "ec_number": "2.1.1.362", "activity": "N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = H(+) + N(6),N(6)-dimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine.", "evidence": [ { "id": "Q3U8K7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3U8K7" } ] }, { "ec_number": "2.1.1.361", "activity": "L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine.", "evidence": [ { "id": "Q3U8K7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3U8K7" } ] }, { "ec_number": "2.1.1.361", "activity": "", "evidence": [ { "id": "Q3U8K7", "database": "UniProtKB", "url": 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