{
    "uniprot_canonical_ac": "A0A8I6AD50-1",
    "uniprot_ac": "A0A8I6AD50",
    "uniprot_id": "A0A8I6AD50_RAT",
    "mass": {
        "chemical_mass": 42200.0,
        "monoisotopic_mass": 42200.0
    },
    "refseq": {
        "ac": "NP_001163813",
        "name": "aldo-keto reductase family 1, member C12",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001163813"
    },
    "gene_names": [
        {
            "name": "Akr1c13",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/A0A8I6AD50",
            "id": "A0A8I6AD50"
        },
        {
            "name": "Akr1c12; Akr1c12T",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006254252",
            "id": "XP_006254252"
        },
        {
            "name": "Akr1c12",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A0A8I6AD50",
            "id": "A0A8I6AD50"
        },
        {
            "name": "Akr1c13",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006254252",
            "id": "XP_006254252"
        }
    ],
    "protein_names": [
        {
            "name": "Aldo-keto reductase family 1, member C13",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "A0A8I6AD50"
        },
        {
            "name": "aldo-keto reductase family 1, member C12 isoform X1",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006254252",
            "id": "XP_006254252"
        },
        {
            "name": "aldo-keto reductase family 1, member C12 temp",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001163813",
            "id": "NP_001163813"
        },
        {
            "name": "aldo-keto reductase family 1, member C12",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001163813",
            "id": "NP_001163813"
        }
    ],
    "function": [],
    "disease": [
        {
            "disease_id": "DOID:0111773",
            "recommended_name": {
                "id": "DOID:0111773",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:0111773",
                "name": "46,XY sex reversal 8",
                "description": "A 46 XY sex reversal characterized by an XY karyotype, phenotypically female genitalia and failure to develop secondary sexual characteristics at puberty including menstruation that has_material_basis_in homozygous or compound heterozygous mutation in the AKR1C2 gene on chromosome 10p15.1."
            },
            "synonyms": [
                {
                    "id": "DOID:0111773",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0111773",
                    "name": "SRXY8",
                    "description": ""
                },
                {
                    "id": "DOID:0111773",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0111773",
                    "name": "TDD",
                    "description": ""
                },
                {
                    "id": "DOID:0111773",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0111773",
                    "name": "male pseudohermaphroditism due to deficiency of testicular 17,20-desmolase",
                    "description": ""
                },
                {
                    "id": "MONDO:0013664",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0013664",
                    "name": "46,XY disorder of sex development due to testicular 17,20-desmolase deficiency",
                    "description": ""
                },
                {
                    "id": "MONDO:0013664",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0013664",
                    "name": "46,XY sex reversal type 8",
                    "description": ""
                },
                {
                    "id": "MONDO:0013664",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0013664",
                    "name": "46XY sex reversal 8",
                    "description": ""
                },
                {
                    "id": "MONDO:0013664",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0013664",
                    "name": "46XY sex reversal 8, modifier of",
                    "description": ""
                },
                {
                    "id": "MONDO:0013664",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0013664",
                    "name": "46,XY sex reversal 8",
                    "description": ""
                },
                {
                    "id": "MONDO:0013664",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0013664",
                    "name": "SRXY8",
                    "description": ""
                },
                {
                    "id": "MONDO:0013664",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0013664",
                    "name": "male pseudohermaphroditism due to deficiency of testicular 17,20-desmolase",
                    "description": ""
                },
                {
                    "id": "MIM:614279",
                    "resource": "MIM",
                    "url": "https://www.omim.org/entry/614279",
                    "name": "46,XY sex reversal 8",
                    "description": "46,XY sex reversal 8"
                }
            ],
            "evidence": [
                {
                    "id": "0111773",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:0111773"
                }
            ]
        }
    ],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Rattus norvegicus",
            "taxid": 10116,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A0A8I6AD50",
                    "url": "https://www.uniprot.org/uniprot/A0A8I6AD50"
                }
            ],
            "common_name": "Rat"
        }
    ],
    "gene": [
        {
            "name": "Akr1c13",
            "url": "https://www.uniprot.org/uniprot/A0A8I6AD50",
            "locus": {
                "chromosome": "17",
                "start_pos": 65997591,
                "end_pos": 65964975,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSRNOG00000062679",
                        "url": "https://www.ensembl.org/id/ENSRNOG00000062679"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSRNOG00000050040",
            "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000050040",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "cd19108",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd19108",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "361266",
            "url": "https://www.ncbi.nlm.nih.gov/gene/361266",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "IPR018170",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR018170",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR020471",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR020471",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR023210",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR023210",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR036812",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR036812",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR044482",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR044482",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "rno:361266",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:361266",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "ILIHSAM",
            "url": "https://omabrowser.org/oma/group/ILIHSAM/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "890110at2759",
            "url": "http://www.orthodb.org/?query=890110at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR11732",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11732",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR11732:SF286",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11732:SF286",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF00248",
            "url": "http://pfam.xfam.org/family/PF00248",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "XP_006254252",
            "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006254252",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "1308232",
            "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1308232",
            "database": "RGD",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "A0A8I6AD50",
            "url": "https://www.uniprot.org/uniprot/A0A8I6AD50",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A8I6AD50-1",
            "url": "https://www.uniprot.org/uniprot/A0A8I6AD50-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "D3ZPY8",
            "url": "https://www.uniprot.org/uniprot/D3ZPY8",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "D3ZPY8-1",
            "url": "https://www.uniprot.org/uniprot/D3ZPY8-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MAASCHYWAMALFKIQSSEYVNQISFGQAEYVAYLQRAEGRMSPLSEPEQAAGFLQVMRHCSCCLCSPGVSASYKLVPKSKSLEAAHLAIDAGYRHIDTAYAYQIEEEIGQAIQSKIKAGVVKREDMFITTKLWCTCFRPELVKPALEKSLKNLQLDYADLYIMHYPVPMKSGDNDFPVDEKGKSLLDTVDFCDTWEMLEKCKDAGLVKSIGVSNFNHKQLERLLNKPGLKYKPVCNQVECHLYLNQSKLLDYCKSKDIVLVAYGALGTQRYKEWVDQNSPVLLNDPVLCDVAKKNKRSPALIALRYLVQRGVVPLAQSFKENEMRENLQVFDFQLSPEDMKTLDGLNKNFRYLSAEFLAGHPEYPFSEEY",
        "length": 371,
        "header": "tr|A0A8I6AD50-1|A0A8I6AD50_RAT Isoform 1 of Aldo-keto reductase family 1, member C13  OS=Rattus norvegicus OX=10116 GN=Akr1c13 PE=1 SV=1 CANONICAL=A0A8I6AD50-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A0A8I6AD50-1",
            "url": "",
            "sequence": {
                "sequence": "MAASCHYWAMALFKIQSSEYVNQISFGQAEYVAYLQRAEGRMSPLSEPEQAAGFLQVMRHCSCCLCSPGVSASYKLVPKSKSLEAAHLAIDAGYRHIDTAYAYQIEEEIGQAIQSKIKAGVVKREDMFITTKLWCTCFRPELVKPALEKSLKNLQLDYADLYIMHYPVPMKSGDNDFPVDEKGKSLLDTVDFCDTWEMLEKCKDAGLVKSIGVSNFNHKQLERLLNKPGLKYKPVCNQVECHLYLNQSKLLDYCKSKDIVLVAYGALGTQRYKEWVDQNSPVLLNDPVLCDVAKKNKRSPALIALRYLVQRGVVPLAQSFKENEMRENLQVFDFQLSPEDMKTLDGLNKNFRYLSAEFLAGHPEYPFSEEY",
                "length": 371,
                "header": "tr|A0A8I6AD50-1|A0A8I6AD50_RAT Isoform 1 of Aldo-keto reductase family 1, member C13  OS=Rattus norvegicus OX=10116 GN=Akr1c13 PE=1 SV=1 CANONICAL=A0A8I6AD50-1"
            },
            "locus": {
                "chromosome": "17",
                "start_pos": 65997380,
                "end_pos": 65965057,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000102233.1",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000102233.1"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000089705.1",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000089705.1"
                    }
                ]
            }
        },
        {
            "isoform_ac": "D3ZPY8-1",
            "url": "",
            "sequence": {
                "sequence": "MSSKQHCVKLNDGHFIPALGFGTYKPKEVPKSKSLEAAHLAIDAGYRHIDTAYAYQIEEEIGQAIQSKIKAGVVKREDMFITTKLWCTCFRPELVKPALEKSLKNLQLDYADLYIMHYPVPMKSGDNDFPVDEKGKSLLDTVDFCDTWEMLEKCKDAGLVKSIGVSNFNHKQLERLLNKPGLKYKPVCNQVECHLYLNQSKLLDYCKSKDIVLVAYGALGTQRYKEWVDQNSPVLLNDPVLCDVAKKNKRSPALIALRYLVQRGVVPLAQSFKENEMRENLQVFDFQLSPEDMKTLDGLNKNFRYLSAEFLAGHPEYPFSEEY",
                "length": 323,
                "header": "tr|D3ZPY8-1|D3ZPY8_RAT Computationally mapped isoform of Aldo-keto reductase family 1, member C13  OS=Rattus norvegicus OX=10116 GN=Akr1c13 PE=1 SV=1 CANONICAL=A0A8I6AD50-1"
            },
            "locus": {
                "chromosome": "17",
                "start_pos": 65997380,
                "end_pos": 65984753,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000029049.6",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000029049.6"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000037905.4",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000037905.4"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [],
    "publication": [],
    "pathway": [
        {
            "id": "rno:361266",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:361266",
            "resource": "KEGG Pathway"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "A2VD16-1",
            "protein_name": "Aldo-keto reductase family 1, member C12-like 1",
            "gene_name": "Akr1c12l1",
            "tax_id": 10116,
            "organism": "Rattus norvegicus",
            "sequence": {
                "sequence": "MSSKHHCVKLNDGHFIPALGFGTSIPNEVPKSKSLEAVHLAIDAGYHHIDTASAYQIEEEIGQAIQSKIKAGVVKREDMFITTKLWCTCFRPELVKPALEKSLKNLQLDYADLYIMHYPVPMKSGDKYLPVDDKGKWLLDTVDFCDTWEMLEKCKDAGLVKSIGVSNFNHKQLERLLNKPGLKYKPVCNQVECHLYMNQSKLLDYCKSKDIVLVAYGALGTQRYKEWVDQNSPVLLDDPVLCDVAKKNKRSPALIALRYLVQREVVPLAQSFKENEMRENLQVFEFQLSPEDMKTLDGLNKNFRYLSAEFLAGHPEYPFSEEY",
                "length": 323
            },
            "evidence": [
                {
                    "id": "45240331",
                    "url": "http://www.informatics.jax.org/homology/45240331",
                    "database": "MGI"
                },
                {
                    "id": "45240330",
                    "url": "http://www.informatics.jax.org/homology/45240330",
                    "database": "MGI"
                }
            ],
            "common_name": "Rat"
        },
        {
            "uniprot_canonical_ac": "P17516-1",
            "protein_name": "Aldo-keto reductase family 1 member C4",
            "gene_name": "AKR1C4",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MDPKYQRVELNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQVGLAIRSKIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPMALKPGETPLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNCRQLEMILNKPGLKYKPVCNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLLEDPVLCALAKKHKQTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLNRNYRYVVMDFLMDHPDYPFSDEY",
                "length": 323
            },
            "evidence": [
                {
                    "id": "45240331",
                    "url": "http://www.informatics.jax.org/homology/45240331",
                    "database": "MGI"
                },
                {
                    "id": "45240330",
                    "url": "http://www.informatics.jax.org/homology/45240330",
                    "database": "MGI"
                }
            ],
            "common_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q5I0M4-1",
            "protein_name": "Aldo-keto reductase family 1, member C12",
            "gene_name": "Akr1c12",
            "tax_id": 10116,
            "organism": "Rattus norvegicus",
            "sequence": {
                "sequence": "MSSKLHCVKLNDGHFIPALGFGTYKPKEVPKSKSLEAAHLAIDVGYRHIDTASAYQVEEEIGQAIQSKIKAGVVKRKDMFITTKLWCSCFRTEMVRPALEKSLKNLQLDYVDLFLIHYPVPIKSSVDESPLDEKGKFLLDTVDFCDTWEMLEKCKDAGLVKSIGVSNFNHKQLERLLNKPGLKYKPVCNQVECHLYLNQSKLLDYCKSKDIVLVAYGALGTQRYKEWVDQNSPVLLDDPILCDVAKKNKRSPALIALRYLFQRGVVPLAQSFKENEMRENLQVFEFQLSPEDMKTLDGLNKNFRYLSAEFLADHPEYPFSEEY",
                "length": 323
            },
            "evidence": [
                {
                    "id": "45240331",
                    "url": "http://www.informatics.jax.org/homology/45240331",
                    "database": "MGI"
                },
                {
                    "id": "45240330",
                    "url": "http://www.informatics.jax.org/homology/45240330",
                    "database": "MGI"
                }
            ],
            "common_name": "Rat"
        },
        {
            "uniprot_canonical_ac": "Q8VC28-1",
            "protein_name": "Aldo-keto reductase family 1 member C13",
            "gene_name": "Akr1c13",
            "tax_id": 10090,
            "organism": "Mus musculus",
            "sequence": {
                "sequence": "MSSKQHCVKLNDGHLIPALGFGTYKPKEVPKSKSLEAACLALDVGYRHVDTAYAYQVEEEIGQAIQSKIKAGVVKREDLFITTKLWCTCFRPELVKPALEKSLKKLQLDYVDLYIMHYPVPMKSGDNDFPVNEQGKSLLDTVDFCDTWERLEECKDAGLVKSIGVSNFNHRQLERILNKPGLKYKPVCNQVECHLYLNQRKLLDYCESKDIVLVAYGALGTQRYKEWVDQNSPVLLNDPVLCDVAKKNKRSPALIALRYLIQRGIVPLAQSFKENEMRENLQVFGFQLSPEDMKTLDGLNKNFRYLPAEFLVDHPEYPFVEEY",
                "length": 323
            },
            "evidence": [
                {
                    "id": "45240331",
                    "url": "http://www.informatics.jax.org/homology/45240331",
                    "database": "MGI"
                }
            ],
            "common_name": "Mouse"
        },
        {
            "uniprot_canonical_ac": "Q9JLI0-1",
            "protein_name": "Aldo-keto reductase a",
            "gene_name": "Akr1c12",
            "tax_id": 10090,
            "organism": "Mus musculus",
            "sequence": {
                "sequence": "MSSKQHYVKLNDGHLIPALGFGTYKPKEVPKSKSLEAACLALDVGYRHVDTAYAYQVEEEIGQAIQSKIKAGVVKREDLFITTKLWCGCFRPELVKPALEKSLKSLQLDYVDLYLIHYPVPMKPGDNESPLDENGKFLLDTVDFCDTWERLEECKDAGLVKSIGVSNFNHRQLERILNKPGLKYKPVCNQVECHLYLNQSKLLDYCKSKDIVLVAYGALGTQRYKEWVDQNSPVLLNDPVLCDVAKRNKRSPALIALRYLFQRGIVPLAQSFKENEMRENLQVFEFQLSPEDMKTLDGLNKNFRYLPAEFLADHPEYPFSEEY",
                "length": 323
            },
            "evidence": [
                {
                    "id": "45240330",
                    "url": "http://www.informatics.jax.org/homology/45240330",
                    "database": "MGI"
                }
            ],
            "common_name": "Mouse"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Molecular Function",
                "total": 3,
                "go_terms": [
                    {
                        "name": "steroid dehydrogenase activity",
                        "id": "GO:0016229",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016229",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A8I6AD50",
                                "url": "https://www.uniprot.org/uniprot/A0A8I6AD50"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "alditol:NADP+ 1-oxidoreductase activity",
                        "id": "GO:0004032",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004032",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A8I6AD50",
                                "url": "https://www.uniprot.org/uniprot/A0A8I6AD50"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "ketosteroid monooxygenase activity",
                        "id": "GO:0047086",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0047086",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A8I6AD50",
                                "url": "https://www.uniprot.org/uniprot/A0A8I6AD50"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Cellular Component",
                "total": 1,
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