The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q63538-1", "A0A0G2KB06-1", "P70618-1", "Q9WTY9-1" ], "evidence": [ { "id": "R-RNO-1247960", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1247960" } ] }, { "id": "R-RNO-168053", "name": "Phosphorylated MAPKs phosphorylate ATF-2", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [ "R-RNO-450336" ], "output_participant_list": [ "R-RNO-450243" ], "enzyme_list": [ "P49186-1", "P63086-1", "P21708-1", "P49185-1", "P49187-1", "A0A0G2KB06-1", "P70618-1" ], "evidence": [ { "id": "R-RNO-168053", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-168053" } ] }, { "id": "R-RNO-187688", "name": "p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A0G2KB06-1", "P70618-1", "Q66H84-1", "Q80ZF4-1" ], "evidence": [ { "id": "R-RNO-187688", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-187688" } ] }, { "id": "R-RNO-198669", "name": "p38MAPK phosphorylates MSK1", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [ "R-RNO-198657" ], "output_participant_list": [ "R-RNO-198683" ], "enzyme_list": [ "A0A0G2KB06-1", "P70618-1", "A0A8I6A7D1-1" ], "evidence": [ { "id": "R-RNO-198669", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-198669" } ] }, { "id": "R-RNO-3229102", "name": "p-MAPKAPK3 phosphorylates BMI1", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q4KLY4-1", "Q6MGB6-1", "A0A0G2KB06-1", "P70618-1", "Q66H84-1" ], "evidence": [ { "id": "R-RNO-3229102", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-3229102" } ] }, { "id": "R-RNO-3238999", "name": "Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK5", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1LN87-1", "A0A0G2KB06-1", "P70618-1" ], "evidence": [ { "id": "R-RNO-3238999", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-3238999" } ] }, { "id": "R-RNO-3239014", "name": "MAPKAPK5 phosphorylates TP53", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1LN87-1", "A0A0G2KB06-1", "P70618-1" ], "evidence": [ { "id": "R-RNO-3239014", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-3239014" } ] }, { "id": "R-RNO-3239019", "name": "Active p38 MAPK phosphorylates MAPKAPK5", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1LN87-1", "A0A0G2KB06-1", "P70618-1" ], "evidence": [ { "id": "R-RNO-3239019", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-3239019" } ] }, { "id": "R-RNO-448955", "name": "Phosphorylation of MEF2 proteins by p38", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q63538-1", "A0A0G2KB06-1", "P70618-1" ], "evidence": [ { "id": "R-RNO-448955", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-448955" } ] }, { "id": "R-RNO-448958", "name": "Nuclear translocation of p38 MAPK", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q8CFN2-1", "Q63538-1", "A0A0G2KB06-1", "P70618-1", "E9PT20-1" ], "evidence": [ { "id": "R-RNO-448958", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-448958" } ] }, { "id": "R-RNO-450222", "name": "Active p38 MAPK phosphorylates MAPKAPK2 or 3", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A0G2KB06-1", "P70618-1", "Q66H84-1", "Q80ZF4-1" ], "evidence": [ { "id": "R-RNO-450222", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-450222" } ] }, { "id": "R-RNO-450257", "name": "Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A0G2KB06-1", "P70618-1", "Q66H84-1", "Q80ZF4-1" ], "evidence": [ { "id": "R-RNO-450257", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-450257" } ] }, { "id": "R-RNO-450333", "name": "Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A0G2KB06-1", "P70618-1", "Q66H84-1", "Q80ZF4-1" ], "evidence": [ { "id": "R-RNO-450333", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-450333" } ] }, { "id": "R-RNO-451366", "name": "Activation of p38MAPK by DSCAM", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q63538-1", "P35465-1", "Q6RUV5-1", "A0A0G2KB06-1", "P70618-1", "Q9WTY9-1" ], "evidence": [ { "id": "R-RNO-451366", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-451366" } ] }, { "id": "R-RNO-5218804", "name": "p38 MAPK activation by VEGFR", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q62844-1", "Q8CFN2-1", "Q63538-1", "O08775-1", "Q64303-1", "A0A0G2KB06-1", "P70618-1", "Q9WTY9-1" ], "evidence": [ { "id": "R-RNO-5218804", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5218804" } ] }, { "id": "R-RNO-9626880", "name": "MAPK11 or MAPK14 phosphorylates NCF1 at Ser345", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A0G2KB06-1", "P70618-1" ], "evidence": [ { "id": "R-RNO-9626880", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9626880" } ] } ], "reaction_participants": [ { "participant_id": "R-RNO-198657", "participant_name": "RPS6KA5 [nucleoplasm]", "crossref": [ { "id": "XP_006240499.1", "database": "RefSeq", "url": "" }, { "id": "ENSRNOG00000004362", "database": "Ensembl", "url": "" }, { "id": "ENSRNOP00000072518", "database": "Ensembl", "url": "" }, { "id": "1308336", "database": "RGD", "url": "" }, { "id": "ENSRNOT00000091693", "database": "Ensembl", "url": "" }, { "id": "A0A0G2K366", "database": "UniProt", "url": "" } ] }, { "participant_id": "R-RNO-198683", "participant_name": "phospho-p-S212,S360,S376,T581-RPS6KA5 [nucleoplasm]", "crossref": [ { "id": "XP_006240499.1", "database": "RefSeq", "url": "" }, { "id": "A0A0G2K366", "database": "UniProt", "url": "" }, { "id": "ENSRNOP00000072518", "database": "Ensembl", "url": "" }, { "id": "ENSRNOT00000091693", "database": "Ensembl", "url": "" }, { "id": "ENSRNOG00000004362", "database": "Ensembl", "url": "" }, { "id": "1308336", "database": "RGD", "url": "" } ] }, { "participant_id": "R-RNO-450243", "participant_name": "phospho-Atf2 [nucleoplasm]", "crossref": [ { "id": "Q00969", "database": "UniProt", "url": "" }, { "id": "621862", "database": "RGD", "url": "" }, { "id": "ENSRNOP00000046001", "database": "Ensembl", "url": "" }, { "id": "ENSRNOG00000001597", "database": "Ensembl", "url": "" }, { "id": "NP_112280.1", "database": "RefSeq", "url": "" }, { "id": "ENSRNOT00000050513", "database": "Ensembl", "url": "" }, { "id": "Q00969", "database": "PRO", "url": "" } ] }, { "participant_id": "R-RNO-450336", "participant_name": "Atf2 [nucleoplasm]", "crossref": [ { "id": "ENSRNOG00000001597", "database": "Ensembl", "url": "" }, { "id": "ENSRNOT00000050513", "database": "Ensembl", "url": "" }, { "id": "Q00969", "database": "PRO", "url": "" }, { "id": "NP_112280.1", "database": "RefSeq", "url": "" }, { "id": "ENSRNOP00000046001", "database": "Ensembl", "url": "" }, { "id": "Q00969", "database": "UniProt", "url": "" }, { "id": "621862", "database": "RGD", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0A0G2KB06", "gene_name": "Mapk11", "activity": [ { "ec_number": "2.7.11.24", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "A0A0G2KB06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2KB06" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0A0G2KB06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2KB06" } ] } ] }, { "uniprot_ac": "A0A8I6A7D1", "gene_name": "Rps6ka5", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "A0A8I6A7D1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6A7D1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A8I6A7D1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6A7D1" } ] } ] }, { "uniprot_ac": "E9PT20", "gene_name": "Abl1", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "E9PT20", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9PT20" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "E9PT20", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9PT20" } ] } ] }, { "uniprot_ac": "F1LN87", "gene_name": "Mapkapk5", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "F1LN87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LN87" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1LN87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LN87" } ] } ] }, { "uniprot_ac": "O08775", "gene_name": "Kdr", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "O08775", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08775" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "O08775", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08775" } ] } ] }, { "uniprot_ac": "P21708", "gene_name": "Mapk3", "activity": [ { "ec_number": "2.7.11.24", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P21708", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P21708" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "P21708", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P21708" } ] } ] }, { "uniprot_ac": "P35465", "gene_name": "Pak1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P35465", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35465" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P35465", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35465" } ] } ] }, { "uniprot_ac": "P49185", "gene_name": "Mapk8", "activity": [ { "ec_number": "2.7.11.24", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P49185", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49185" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "P49185", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49185" } ] } ] }, { "uniprot_ac": "P49186", "gene_name": "Mapk9", "activity": [ { "ec_number": "2.7.11.24", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P49186", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49186" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "P49186", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49186" } ] } ] }, { "uniprot_ac": "P49187", "gene_name": "Mapk10", "activity": [ { "ec_number": "2.7.11.24", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P49187", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49187" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "P49187", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49187" } ] } ] }, { "uniprot_ac": "P63086", "gene_name": "Mapk1", "activity": [ { "ec_number": "2.7.11.24", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P63086", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P63086" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "P63086", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P63086" } ] } ] }, { "uniprot_ac": "P70618", "gene_name": "Mapk14", "activity": [ { "ec_number": "2.7.11.24", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P70618", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P70618" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "P70618", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P70618" } ] } ] }, { "uniprot_ac": "Q4KLY4", "gene_name": "Rnf2", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q4KLY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4KLY4" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q4KLY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4KLY4" } ] } ] }, { "uniprot_ac": "Q62844", "gene_name": "Fyn", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q62844", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62844" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q62844", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62844" } ] } ] }, { "uniprot_ac": "Q63538", "gene_name": "Mapk12", "activity": [ { "ec_number": "2.7.11.24", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q63538", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63538" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "Q63538", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63538" } ] } ] }, { "uniprot_ac": "Q64303", "gene_name": "Pak2", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q64303", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64303" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q64303", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64303" } ] } ] }, { "uniprot_ac": "Q66H84", "gene_name": "Mapkapk3", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q66H84", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q66H84" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q66H84", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q66H84" } ] } ] }, { "uniprot_ac": "Q6MGB6", "gene_name": "Ring1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q6MGB6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6MGB6" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q6MGB6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6MGB6" } ] } ] }, { "uniprot_ac": "Q6RUV5", "gene_name": "Rac1", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "Q6RUV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6RUV5" } ] }, { "ec_number": "3.6.5.2", "activity": "", 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