{ "uniprot_canonical_ac": "A0A0G2K1P8-1", "uniprot_ac": "A0A0G2K1P8", "uniprot_id": "A0A0G2K1P8_RAT", "mass": { "chemical_mass": 221149.0, "monoisotopic_mass": 221149.0 }, "refseq": {}, "gene_names": [ { "name": "Triobp", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A0A0G2K1P8", "id": "A0A0G2K1P8" } ], "protein_names": [ { "name": "TRIO and F-actin binding protein", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "A0A0G2K1P8" } ], "function": [], "disease": [ { "disease_id": "DOID:0110486", "recommended_name": { "id": "DOID:0110486", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110486", "name": "autosomal recessive nonsyndromic deafness 28", "description": "An autosomal recessive nonsyndromic deafness that is characterized by prelingual onset with severe to profound, stable hearing loss and has_material_basis_in mutation in the TRIOBP gene on chromosome 22q13." }, "synonyms": [ { "id": "DOID:0110486", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110486", "name": "DFNB28", "description": "" }, { "id": "DOID:0110486", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110486", "name": "autosomal recessive deafness 28", "description": "" }, { "id": "MONDO:0012355", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012355", "name": "autosomal recessive nonsyndromic hearing loss 28", "description": "An autosomal recessive disorder caused by mutations in the TRIOBP gene, encoding TRIO and F-actin-binding protein. The condition is characterized by severe to profound sensorineural hearing loss." }, { "id": "MONDO:0012355", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012355", "name": "DFNB28", "description": "" }, { "id": "MONDO:0012355", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012355", "name": "TRIOBP autosomal recessive nonsyndromic deafness", "description": "" }, { "id": "MONDO:0012355", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012355", "name": "autosomal recessive deafness 28", "description": "" }, { "id": "MONDO:0012355", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012355", "name": "autosomal recessive nonsyndromic deafness 28", "description": "" }, { "id": "MONDO:0012355", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012355", "name": "autosomal recessive nonsyndromic deafness caused by mutation in TRIOBP", "description": "" }, { "id": "MONDO:0012355", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012355", "name": "autosomal recessive nonsyndromic deafness type 28", "description": "" }, { "id": "MONDO:0012355", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012355", "name": "deafness, autosomal recessive 28", "description": "" }, { "id": "MONDO:0012355", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012355", "name": "deafness, autosomal recessive type 28", "description": "" }, { "id": "MIM:609823", "resource": "MIM", "url": "https://www.omim.org/entry/609823", "name": "Deafness, autosomal recessive, 28", "description": "Deafness, autosomal recessive, 28" } ], "evidence": [ { "id": "0110486", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0110486" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K1P8", "url": "https://www.uniprot.org/uniprot/A0A0G2K1P8" } ], "common_name": "Rat" } ], "gene": [ { "name": "Triobp", "url": "https://www.uniprot.org/uniprot/A0A0G2K1P8", "locus": { "chromosome": "7", "start_pos": 110562474, "end_pos": 110506248, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000059015", "url": "https://www.ensembl.org/id/ENSRNOG00000059015" } ] } } ], "crossref": [ { "id": "ENSRNOG00000059015", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000059015", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd13275", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd13275", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "362956", "url": "https://www.ncbi.nlm.nih.gov/gene/362956", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001849", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001849", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011993", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011993", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039597", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039597", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "rno:362956", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:362956", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "YIPPAVC", "url": "https://omabrowser.org/oma/group/YIPPAVC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "2961037at2759", "url": "http://www.orthodb.org/?query=2961037at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR17271", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR17271", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR17271:SF10", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR17271:SF10", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00169", "url": "http://pfam.xfam.org/family/PF00169", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "XP_017450470", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017450470", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "1308485", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1308485", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "A0A0G2K1P8", "url": "https://www.uniprot.org/uniprot/A0A0G2K1P8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0G2K1P8-1", "url": "https://www.uniprot.org/uniprot/A0A0G2K1P8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0G2K6B2", "url": "https://www.uniprot.org/uniprot/A0A0G2K6B2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0G2K6B2-1", "url": "https://www.uniprot.org/uniprot/A0A0G2K6B2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6AHC8", "url": "https://www.uniprot.org/uniprot/A0A8I6AHC8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6AHC8-1", "url": "https://www.uniprot.org/uniprot/A0A8I6AHC8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6G2J5", "url": "https://www.uniprot.org/uniprot/A0A8I6G2J5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6G2J5-1", "url": "https://www.uniprot.org/uniprot/A0A8I6G2J5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSMEQDTRALLPTQGTAWATASVPVARLQGPQGDSHQACSQEPHSPPSAEAPYCDLPRCPPALQDPLHTTTCVGQSVDNLGLGLDQEPQRIGSPTTALPADPRNRHRDPEAIPYLEGPAYSTDEHKDEDPNSNTSSSQDSNTPHDTSNSSSVQDWDTVERPGVVPNRNRLTMMIPRRPQEGLRTDSAQKVTRSPARGDTAGQRKENSGSGGQSAGQHWVKLRSESGYFSLERQRSGQTQASSGTPPSGPRTTTQASSAQRDVSQAASAQEAPQTSSLPRNTQRDTQRSTPRTSSPSRVSQRDTPRIMSTQRKNTPLSSPLRPTPETLKTSAPEDGPHVTSPLCAQDSSLNRTTQRDSSRTSCAQRNNPRTSSPNRTTQRDNPRTSCAQRNNPRTSSPNRTTQQDNPRTSCAQRNNPRTSSPSRTTQHDNPRTSCAQRDNPRTSSPNRTTQQDNPRMSCAQRNNPRTSSPNRTTQRDNLRTSCAQRNNPRTSSPNRTIHQDNPRTSCVSQNTPRTSSTQVDKTTASCSRWEHLRSACTQRDNPRTLSQGCTQKDNPGPSSPHRATQGSSSRNPSPHRTNKDIPWASFPLRPTQSDSSRTSSPSRTKQNQVPWASISLRPTQGDKPQTSAPSKLAHNDPPQQYSPSLATSSSSSHNPGHPSASRTSSPLHPAPRGAPQTSLEPSQPPCAVCIGHRDAPRASSPPRYFQYDPFPFFPDPRSSESESPHHEPPYMPPAVCIGHRDAPRATSPPRHTQFDPFPFLPDTSDAENESPQHDPPQFPPPVCIGYRDAPRASSPPRQFPEPSFFQDLPRASTESLVPSTDSMHEPPHIPTPVCIGHRDAPSFSSPPRQAPEPSLFFQDPPGTSMESLAPSVDSLHGSPLLLPQVCIGHRDAPRASSPPRHPPSDVGILAPSPPPGSSGSRGSAPPGETRHNLEREEYTMLADLPPPRRLAQRVPEPQAQGSNEGRTRSPGRAEVERLFGQERRKSEAPGAFQARDEGRSQRPSQGQSQLRRQSSPAPSRQVTKPSAKQAEPTRQSRTGPPHPKSPEKHSEGDRQLQRIAPPARTSARPPERKAQIERHLESGYTGLRQPLGGWQSREGLSGPQSPNRHPEKNWGSQEEGLSLGGWPELGGPSLEGIWRGPPQEHRERWGQSEAWEEPPSNGIQGGPPRGQGSLQELPRPHQPPPSPENSWAGPAECFCARQPEAGTAMGWRAEGTSPHQYSAERPPDLDWRDLLGLLRAPEDGAWTRLPRLDWEGLLELLQARLPQKDPTRHSRDPAKAPGPEPGSSDTEDTLKTESQTQPEGWAKATLANGHRPGQQSESPAQLPSPACTSTQWPTTKVTSGPETSPPVALEQIDHLESHSPPDLGADKRPAEGKAGSPLKGRLVTSWRMPGDRPALFNPYLLSLGVLRWQRPDLLNFKKGWMSILDEPGEWKKHWFVLTDSSLKYYRDSTAEEADELDGEIDLRSCTDVTEYAVQRNYGFQIHTKDAVYTLSAMTSGIRRNWIEALRKTVRPTSAPDVTKLSECNKENTLHGYGTQKSSLKIGEQRTGSEVIGRGGPRKVDGSRQSLDYVELSPLTPSSPQRVRTLSRSTPERPSKQEDLERDLAQRSEERRKWFESTDSRTPETPSGDGSRRGLGAPLTDDQQSRLSEEIEKKWQELEKLPLRENKRVPLTALLNQGHSERRGPTSDSHEALEKEVQSLRAQLEAWRLRGEAPQNAPRLQEDSHIPPGYISQEACERSLAEMESSHQQVMEQLQRHHERELQRLQQEKEWLLAEETAATASAIEAMKKAYQEELSRELSKTRSLQQGPDSLRKQHQLDMEALKQELQVLSERYSQKCLEIGALTRQAEEREHTLRCCQQEGQELLRHNQELHSHLSEEIDRLRSFIASQGTGNSCGRSNERSSCELEVLLRVKENELQYLKKEVQCLRDELQVIQKDKRFTGKYQDVYVELNHIKTRSEREIEQLKEHLRLAMAALQEKEAVRNSLAE", "length": 1992, "header": "tr|A0A0G2K1P8-1|A0A0G2K1P8_RAT Isoform 1 of TRIO and F-actin binding protein OS=Rattus norvegicus OX=10116 GN=Triobp PE=1 SV=2 CANONICAL=A0A0G2K1P8-1" }, "isoforms": [ { "isoform_ac": "A0A0G2K1P8-1", "url": "", "sequence": { "sequence": "MSMEQDTRALLPTQGTAWATASVPVARLQGPQGDSHQACSQEPHSPPSAEAPYCDLPRCPPALQDPLHTTTCVGQSVDNLGLGLDQEPQRIGSPTTALPADPRNRHRDPEAIPYLEGPAYSTDEHKDEDPNSNTSSSQDSNTPHDTSNSSSVQDWDTVERPGVVPNRNRLTMMIPRRPQEGLRTDSAQKVTRSPARGDTAGQRKENSGSGGQSAGQHWVKLRSESGYFSLERQRSGQTQASSGTPPSGPRTTTQASSAQRDVSQAASAQEAPQTSSLPRNTQRDTQRSTPRTSSPSRVSQRDTPRIMSTQRKNTPLSSPLRPTPETLKTSAPEDGPHVTSPLCAQDSSLNRTTQRDSSRTSCAQRNNPRTSSPNRTTQRDNPRTSCAQRNNPRTSSPNRTTQQDNPRTSCAQRNNPRTSSPSRTTQHDNPRTSCAQRDNPRTSSPNRTTQQDNPRMSCAQRNNPRTSSPNRTTQRDNLRTSCAQRNNPRTSSPNRTIHQDNPRTSCVSQNTPRTSSTQVDKTTASCSRWEHLRSACTQRDNPRTLSQGCTQKDNPGPSSPHRATQGSSSRNPSPHRTNKDIPWASFPLRPTQSDSSRTSSPSRTKQNQVPWASISLRPTQGDKPQTSAPSKLAHNDPPQQYSPSLATSSSSSHNPGHPSASRTSSPLHPAPRGAPQTSLEPSQPPCAVCIGHRDAPRASSPPRYFQYDPFPFFPDPRSSESESPHHEPPYMPPAVCIGHRDAPRATSPPRHTQFDPFPFLPDTSDAENESPQHDPPQFPPPVCIGYRDAPRASSPPRQFPEPSFFQDLPRASTESLVPSTDSMHEPPHIPTPVCIGHRDAPSFSSPPRQAPEPSLFFQDPPGTSMESLAPSVDSLHGSPLLLPQVCIGHRDAPRASSPPRHPPSDVGILAPSPPPGSSGSRGSAPPGETRHNLEREEYTMLADLPPPRRLAQRVPEPQAQGSNEGRTRSPGRAEVERLFGQERRKSEAPGAFQARDEGRSQRPSQGQSQLRRQSSPAPSRQVTKPSAKQAEPTRQSRTGPPHPKSPEKHSEGDRQLQRIAPPARTSARPPERKAQIERHLESGYTGLRQPLGGWQSREGLSGPQSPNRHPEKNWGSQEEGLSLGGWPELGGPSLEGIWRGPPQEHRERWGQSEAWEEPPSNGIQGGPPRGQGSLQELPRPHQPPPSPENSWAGPAECFCARQPEAGTAMGWRAEGTSPHQYSAERPPDLDWRDLLGLLRAPEDGAWTRLPRLDWEGLLELLQARLPQKDPTRHSRDPAKAPGPEPGSSDTEDTLKTESQTQPEGWAKATLANGHRPGQQSESPAQLPSPACTSTQWPTTKVTSGPETSPPVALEQIDHLESHSPPDLGADKRPAEGKAGSPLKGRLVTSWRMPGDRPALFNPYLLSLGVLRWQRPDLLNFKKGWMSILDEPGEWKKHWFVLTDSSLKYYRDSTAEEADELDGEIDLRSCTDVTEYAVQRNYGFQIHTKDAVYTLSAMTSGIRRNWIEALRKTVRPTSAPDVTKLSECNKENTLHGYGTQKSSLKIGEQRTGSEVIGRGGPRKVDGSRQSLDYVELSPLTPSSPQRVRTLSRSTPERPSKQEDLERDLAQRSEERRKWFESTDSRTPETPSGDGSRRGLGAPLTDDQQSRLSEEIEKKWQELEKLPLRENKRVPLTALLNQGHSERRGPTSDSHEALEKEVQSLRAQLEAWRLRGEAPQNAPRLQEDSHIPPGYISQEACERSLAEMESSHQQVMEQLQRHHERELQRLQQEKEWLLAEETAATASAIEAMKKAYQEELSRELSKTRSLQQGPDSLRKQHQLDMEALKQELQVLSERYSQKCLEIGALTRQAEEREHTLRCCQQEGQELLRHNQELHSHLSEEIDRLRSFIASQGTGNSCGRSNERSSCELEVLLRVKENELQYLKKEVQCLRDELQVIQKDKRFTGKYQDVYVELNHIKTRSEREIEQLKEHLRLAMAALQEKEAVRNSLAE", "length": 1992, "header": "tr|A0A0G2K1P8-1|A0A0G2K1P8_RAT Isoform 1 of TRIO and F-actin binding protein OS=Rattus norvegicus OX=10116 GN=Triobp PE=1 SV=2 CANONICAL=A0A0G2K1P8-1" }, "locus": { "chromosome": "7", "start_pos": 110561274, "end_pos": 110508586, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000087548.2", "url": "https://www.ensembl.org/id/ENSRNOT00000087548.2" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000071930.2", "url": "https://www.ensembl.org/id/ENSRNOP00000071930.2" } ] } }, { "isoform_ac": "A0A0G2K6B2-1", "url": "", "sequence": { "sequence": "MTPDLLNFKKGWMSILDEPGEWKKHWFVLTDSSLKYYRDSTAEEADELDGEIDLRSCTDVTEYAVQRNYGFQIHTKDAVYTLSAMTSGIRRNWIEALRKTVRPTSAPDVTKLSECNKENTLHGYGTQKSSLKIGEQRTGSEVIGRGGPRKVDGSRQSLDYVELSPLTPSSPQRVRTLSRSTPERPSKQEDLERDLAQRSEERRKWFESTDSRTPETPSGDGSRRGLGAPLTDDQQSRLSEEIEKKWQELEKLPLRENKRVPLTALLNQGHSERRGPTSDSHEALEKEVQSLRAQLEAWRLRGEAPQNAPRLQEDSHIPPGYISQEACERSLAEMESSHQQVMEQLQRHHERELQRLQQEKEWLLAEETAATASAIEAMKKAYQEELSRELSKTRSLQQGPDSLRKQHQLDMEALKQELQVLSERYSQKCLEIGALTRQAEEREHTLRCCQQEGQELLRHNQELHSHLSEEIDRLRSFIASQGTGNSCGRSNERSSCELEVLLRVKENELQYLKKEVQCLRDELQVIQKDKRFTGKYQDVYVELNHIKTRSEREIEQLKEHLRLAMAALQEKEAVRNSLAE", "length": 580, "header": "tr|A0A0G2K6B2-1|A0A0G2K6B2_RAT Computationally mapped isoform of TRIO and F-actin binding protein OS=Rattus norvegicus OX=10116 GN=Triobp PE=1 SV=1 CANONICAL=A0A0G2K1P8-1" }, "locus": { "chromosome": "7", "start_pos": 110561274, "end_pos": 110543319, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000086853.2", "url": "https://www.ensembl.org/id/ENSRNOT00000086853.2" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000073745.1", "url": "https://www.ensembl.org/id/ENSRNOP00000073745.1" } ] } }, { "isoform_ac": "A0A8I6AHC8-1", "url": "", "sequence": { "sequence": "MGGWKGPGQLRGREGLELRRPAAERGGGLGAPRSPARESRAASSGAAMTPDLLNFKKGWMSILDEPGEWKKHWFVLTDSSLKYYRDSTAEEADELDGEIDLRSCTDVTEYAVQRNYGFQIHTKDAVYTLSAMTSGIRRNWIEALRKTVRPTSAPDVTKLSECNKENTLHGYGTQKSSLKIGEQRTGSEVIGRGGPRKVDGSRQSLDYVELSPLTPSSPQRVRTLSRSTPERPSKQEDLERDLAQRSEERRKWFESTDSRTPETPSGDGSRRGLGAPLTDDQQSRLSEEIEKKWQELEKLPLRENKRVPLTALLNQGHSERRGPTSDSHEALEKEVQSLRAQLEAWRLRGEAPQNAPRLQEDSHIPPGYISQEACERSLAEMESSHQQVMEQLQRHHERELQRLQQEKEWLLAEETAATASAIEAMKKAYQEELSRELSKTRSLQQGPDSLRKQHQLDMEALKQELQVLSERYSQKCLEIGALTRQAEEREHTLRCCQQEGQELLRHNQELHSHLSEEIDRLRSFIASQGTGNSCGRSNERSSCELEVLLRVKENELQYLKKEVQCLRDELQVIQKDKRFTGKYQDVYVELNHIKTRSEREIEQLKEHLRLAMAALQEKEAVRNSLAE", "length": 627, "header": "tr|A0A8I6AHC8-1|A0A8I6AHC8_RAT Computationally mapped isoform of TRIO and F-actin binding protein OS=Rattus norvegicus OX=10116 GN=Triobp PE=1 SV=1 CANONICAL=A0A0G2K1P8-1" }, "locus": { "chromosome": "7", "start_pos": 110561274, "end_pos": 110538166, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000112806.1", "url": "https://www.ensembl.org/id/ENSRNOT00000112806.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000092060.1", "url": "https://www.ensembl.org/id/ENSRNOP00000092060.1" } ] } }, { "isoform_ac": "A0A8I6G2J5-1", "url": "", "sequence": { "sequence": "MSMEQDTRALLPTQGTAWATASVPVARLQGPQGDSHQACSQEPHSPPSAEAPYCDLPRCPPALQDPLHTTTCVGQSVDNLGLGLDQEPQRIGSPTTALPADPRNRHRDPEAIPYLEGPAYSTDEHKDEDPNSNTSSSQDSNTPHDTSNSSSVQDWDTVERPGVVPNRNRLTMMIPRRPQEGLRTDSAQKVTRSPARGDTAGQRKENSGSGGQSAGQHWVKLRSESGYFSLERQRSGQTQASSGTPPSGPRTTTQASSAQRDVSQAASAQEAPQTSSLPRNTQRDTQRSTPRTSSPSRVSQRDTPRIMSTQRKNTPLSSPLRPTPETLKTSAPEDGPHVTSPLCAQDSSLNRTTQRDSSRTSCAQRNNPRTSSPNRTTQRDNPRTSCAQRNNPRTSSPNRTTQQDNPRTSCAQRNNPRTSSPSRTTQHDNPRTSCAQRDNPRTSSPNRTTQQDNPRMSCAQRNNPRTSSPNRTTQRDNLRTSCAQRNNPRTSSPNRTIHQDNPRTSCVSQNTPRTSSTQVDKTTASCSRWEHLRSACTQRDNPRTLSQGCTQKDNPGPSSPHRATQGSSSRNPSPHRTNKDIPWASFPLRPTQSDSSRTSSPSRTKQNQVPWASISLRPTQGDKPQTSAPSKLAHNDPPQQYSPSLATSSSSSHNPGHPSASRTSSPLHPAPRGAPQTSLEPSQPPCAVCIGHRDAPRASSPPRYFQYDPFPFFPDPRSSESESPHHEPPYMPPAVCIGHRDAPRATSPPRHTQFDPFPFLPDTSDAENESPQHDPPQFPPPVCIGYRDAPRASSPPRQFPEPSFFQDLPRASTESLVPSTDSMHEPPHIPTPVCIGHRDAPSFSSPPRQAPEPSLFFQDPPGTSMESLAPSVDSLHGSPLLLPQVCIGHRDAPRASSPPRHPPSDVGILAPSPPPGSSGSRGSAPPGETRHNLEREEYTMLADLPPPRRLAQRVPEPQAQGSNEGRTRSPGRAEVERLFGQERRKSEAPGAFQARDEGRSQRPSQGQSQLRRQSSPAPSRQVTKPSAKQAEPTRQSRTGPPHPKSPEKHSEGDRQLQRIAPPARTSARPPERKAQIERHLESGYTGLRQPLGGWQSREGLSGPQSPNRHPEKNWGSQEEGLSLGGWPELGGPSLEGIWRGPPQEHRERWGQSEAWEEPPSNGIQGGPPRGQGSLQELPRPHQPPPSPENSWAGPAECFCARQPEAGTAMGWRAEGTSPHQYSAERPPDLDWRDLLGLLRAPEDGAWTRLPRLDWEGLLELLQARLPQKDPTRHSRDPAKAPGPEPGSSDTEDTLKTESQTQPEGWAKATLANGHRPGQQSESPAQLPSPACTSTQWPTTKVTSGPETSPPVALEQIDHLESHSPPDLGPEEPEASEPSRGEDSLADQKQADSPDLLNFKKGWMSILDEPGEWKKHWFVLTDSSLKYYRDSTAEEADELDGEIDLRSCTDVTEYAVQRNYGFQIHTKDAVYTLSAMTSGIRRNWIEALRKTVRPTSAPDVTKLSECNKENTLHGYGTQKSSLKIGEQRTGSEVIGRGGPRKVDGSRQSLDYVELSPLTPSSPQRVRTLSRSTPERPSKQEDLERDLAQRSEERRKWFESTDSRTPETPSGDGSRRGLGAPLTDDQQSRLSEEIEKKWQELEKLPLRENKRVPLTALLNQGHSERRGPTSDSHEALEKEVQSLRAQLEAWRLRGEAPQNAPRLQEDSHIPPGYISQEACERSLAEMESSHQQVMEQLQRHHERELQRLQQEKEWLLAEETAATASAIEAMKKAYQEELSRELSKTRSLQQGPDSLRKQHQLDMEALKQELQVLSERYSQKCLEIGALTRQAEEREHTLRCCQQEGQELLRHNQELHSHLSEEIDRLRSFIASQGTGNSCGRSNERSSCELEVLLRVKENELQYLKKEVQCLRDELQVIQKDKRFTGKYQDVYVELNHIKTRSEREIEQLKEHLRLAMAALQEKEAVRNSLAE", "length": 1970, "header": "tr|A0A8I6G2J5-1|A0A0G2K1P8_RAT Computationally mapped isoform of TRIO and F-actin binding protein OS=Rattus norvegicus OX=10116 GN=Triobp PE=1 SV=1 CANONICAL=A0A0G2K1P8-1" }, "locus": { "chromosome": "7", "start_pos": 110561274, "end_pos": 110508586, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000094572.1", "url": "https://www.ensembl.org/id/ENSRNOT00000094572.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000078284.1", "url": "https://www.ensembl.org/id/ENSRNOP00000078284.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.", "journal": "Nat. Commun.", "date": "2012", "authors": "Lundby A, Secher A, Lage K, Nordsborg NB, Dmytriyev A, Lundby C, Olsen JV", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K1P8", "url": "https://www.uniprot.org/uniprot/A0A0G2K1P8" }, { "database": "UniProtKB", "id": "A0A0G2K6B2", "url": "https://www.uniprot.org/uniprot/A0A0G2K6B2" } ], "reference": [ { "type": "PubMed", "id": "22673903", "url": "https://glygen.org/publication/PubMed/22673903" } ] } ], "pathway": [ { "id": "rno:362956", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:362956", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "Q99KW3-3", "protein_name": "TRIO and F-actin-binding protein", "gene_name": "Triobp", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSMEQDTRALLPTQGTAWATASAPVARLQGPQGDSHQACSQEPHSPSSAEAPYCDLPRCPPALQNPLRTTTCVGQSVHSLGLGLGQEPQRVWSPTTALPAEGPAAAPKNRHQDSEGIPYLEGLARSSCTDDNDNKDEDEDPNSNTSSSQDSNTPHDTSNSSSVDWDTTERPGVVPSRNRLTEMIPRRPQEGLRADSARKATRSPARGDTAGQRKENSGSGGQSAGQHWAKLRSESGYFSLERQRSGQTQASSGTPPSGPRGTTQASSAQRDVFQAAPAQEAPQTSSLPRNTQRDTQRSTPRTSSPSRVSQRDTPRVMSTQRKNTPLSSPLRATPETLKISAPEDGTHVTPSPCVQDSSLNRTSQRDSSRTPCIQWDNPRASSPNRTTQRDNPRTPCTQRDNPRASSPNRTTQRDNPRTPCTQRDNPRASSPNRTTQRDNPRTPCAQRDNPRAASPNRSTQRDSPRTPCAQRDNPRASSPNRTAQRDNPRTPCAQRDNPRTSCTSQNTPRTPSTQADKTTASCSKWEHLRSACTQRDNPRTFSQGCTQKDNPGPPSPRRATQGSNSRNPSPHRTNKDIPWASFPLRPTQSDSPRTSSPSRTKQNQVPWASISLRPTQGDKPQTSAPTRLAHNDPPQQYSPSLATTSSSSHNPGHSSASRTSSPLHAAPRGAPQTSLESSQPPCTVCIGHRDAPRASSPPRYFQYDPFPFFPDPRSSESESPHHEPPYMPPAVCIGHRDAPRATSPPRHTQFDPFPFLPDTSDADNESPQHDPPQFPPPVCIGYRDAPRASSPPRQFPEPSFFQDLPRASTESLVPSTDSMHEPPHIPTPVCIGHRDAPSFSSPPRQAPEPSLFFQDPPGTSMESLAPSIDSLHGCPLLPPQVCIGHRDAPRASSPPRHPPSDIGLLAPSPPPGSSGSRGSAPPGETRHNLEREEYTMLADLPPPRRLAQRGPEPQAQGSNEGRTRSPGRAEVERLFGQERRKSEAPGAFQTRDEGRSQRPSQAQSQLRRQSSPAPSRQVTKPSAKQAEPTRQSRTGPPHPKSPDKRPEGDRQLQRTSPPARTPARPPERKAQIERHLESGHTGPRQSLGGWQSQERLSGPQSPNRHPEKSWGSQKEGPSLGGWPELEGPSLEGIWRGPPQEHREQWGHSEAWEEPPSNGIQGAPPRGQGRLQELSRPHQPTPSSENSWAGPAECSCALQPEASTAVGWRAEGTSPHQRSAERPPDLDWRDLLGLLRAPEDGAWTRLPRLDWEGLLELLQARLPQKDPARHWHDPAKASGPEQGSSGTEDTLKTEPQTQPEGRAKATLANGHRPGQQSESPAQLPSPACTSTQWPTTKVTSGPETSPLAALEQIDHLESHSPPDLEFQPEEPEASEPSRGEDSRAVQKQADSADKRPAEGKAGSPLKGRLVTSWRMPGDRPALFNPYLLSLGVLRWQRPDLLNFKKGWMSILDEPGEWKKHWFVLTDSSLKYYRDSTAEEADELDGEIDLRSCTDVTEYAVQRNYGFQIHTKDAVYTLSAMTSGIRRNWIEALRKTVRPTSAPDVTKLSDCNKENTLHGYGTQKSSLKIGEQRTGSEVIGRGGPRKADGPRPSLDYVELSPLAPSSPQRMRTLSRSTPERPTKQEDLERDLAQRSEERRKWFESTDGRTPETPSGDGSRRGLGAPLTDDQQSRLSEEIEKKWQELEKLPLRENKRVPLTALLNQAHNDRRGPTSDSHEALEKEVQSLRAQLEAWRLRGEAPQNAPRLQEDSHIPPGYISQEACERSLAEMESSHQQVMEQLQRHHERELQRLQQEKEWLLAEETAATASAIEAMKKAYQEELSRELSKTRSLQQGPESLRKQHQLDMEALKQELQVLSERYSQKCLEIGALTRQAEEREHTLRRCQQEGQELLRHNQELHSHLSEEIDRLRSFIASQGTGNSCGRSNERSSCELEVLLRVKENELQYLKKEVQCLRDELQVIQKDKRFTGKYQDVYVELNHIKTRSEREIEQLKEHLRLAMAALQEKEAVRNSLAE", "length": 2014 }, "evidence": [ { "id": "45236255", "url": "http://www.informatics.jax.org/homology/45236255", "database": "MGI" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9H2D6-1", "protein_name": "TRIO and F-actin-binding protein", "gene_name": "TRIOBP", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEEVPGDALCEHFEANILTQNRCQNCFHPEEAHGARYQELRSPSGAEVPYCDLPRCPPAPEDPLSASTSGCQSVVDPGLRPGPKRGPSPSAGLPEEGPTAAPRSRSRELEAVPYLEGLTTSLCGSCNEDPGSDPTSSPDSATPDDTSNSSSVDWDTVERQEEEAPSWDELAVMIPRRPREGPRADSSQRAPSLLTRSPVGGDAAGQKKEDTGGGGRSAGQHWARLRGESGLSLERHRSTLTQASSMTPHSGPRSTTSQASPAQRDTAQAASTREIPRASSPHRITQRDTSRASSTQQEISRASSTQQETSRASSTQEDTPRASSTQEDTPRASSTQWNTPRASSPSRSTQLDNPRTSSTQQDNPQTSFPTCTPQRENPRTPCVQQDDPRASSPNRTTQRENSRTSCAQRDNPKASRTSSPNRATRDNPRTSCAQRDNPRASSPSRATRDNPTTSCAQRDNPRASRTSSPNRATRDNPRTSCAQRDNPRASSPSRATRDNPTTSCAQRDNPRASRTSSPNRATRDNPRTSCAQRDNPRASSPNRAARDNPTTSCAQRDNPRASRTSSPNRATRDNPRTSCAQRDNPRASSPNRATRDNPTTSCAQRDNPRASRTSSPNRATRDNPRTSCAQRDNPRASSPNRTTQQDSPRTSCARRDDPRASSPNRTIQQENPRTSCALRDNPRASSPSRTIQQENPRTSCAQRDDPRASSPNRTTQQENPRTSCARRDNPRASSRNRTIQRDNPRTSCAQRDNPRASSPNRTIQQENLRTSCTRQDNPRTSSPNRATRDNPRTSCAQRDNLRASSPIRATQQDNPRTCIQQNIPRSSSTQQDNPKTSCTKRDNLRPTCTQRDRTQSFSFQRDNPGTSSSQCCTQKENLRPSSPHRSTQWNNPRNSSPHRTNKDIPWASFPLRPTQSDGPRTSSPSRSKQSEVPWASIALRPTQGDRPQTSSPSRPAQHDPPQSSFGPTQYNLPSRATSSSHNPGHQSTSRTSSPVYPAAYGAPLTSPEPSQPPCAVCIGHRDAPRASSPPRYLQHDPFPFFPEPRAPESEPPHHEPPYIPPAVCIGHRDAPRASSPPRHTQFDPFPFLPDTSDAEHQCQSPQHEPLQLPAPVCIGYRDAPRASSPPRQAPEPSLLFQDLPRASTESLVPSMDSLHECPHIPTPVCIGHRDAPSFSSPPRQAPEPSLFFQDPPGTSMESLAPSTDSLHGSPVLIPQVCIGHRDAPRASSPPRHPPSDLAFLAPSPSPGSSGGSRGSAPPGETRHNLEREEYTVLADLPPPRRLAQRQPGPQAQCSSGGRTHSPGRAEVERLFGQERRKSEAAGAFQAQDEGRSQQPSQGQSQLLRRQSSPAPSRQVTMLPAKQAELTRRSQAEPPHPWSPEKRPEGDRQLQGSPLPPRTSARTPERELRTQRPLESGQAGPRQPLGVWQSQEEPPGSQGPHRHLERSWSSQEGGLGPGGWWGCGEPSLGAAKAPEGAWGGTSREYKESWGQPEAWEEKPTHELPRELGKRSPLTSPPENWGGPAESSQSWHSGTPTAVGWGAEGACPYPRGSERRPELDWRDLLGLLRAPGEGVWARVPSLDWEGLLELLQARLPRKDPAGHRDDLARALGPELGPPGTNDVPEQESHSQPEGWAEATPVNGHSPALQSQSPVQLPSPACTSTQWPKIKVTRGPATATLAGLEQTGPLGSRSTAKGPSLPELQFQPEEPEESEPSRGQDPLTDQKQADSADKRPAEGKAGSPLKGRLVTSWRMPGDRPTLFNPFLLSLGVLRWRRPDLLNFKKGWMSILDEPGEPPSPSLTTTSTSQWKKHWFVLTDSSLKYYRDSTAEEADELDGEIDLRSCTDVTEYAVQRNYGFQIHTKDAVYTLSAMTSGIRRNWIEALRKTVRPTSAPDVTKLSDSNKENALHSYSTQKGPLKAGEQRAGSEVISRGGPRKADGQRQALDYVELSPLTQASPQRARTPARTPDRLAKQEELERDLAQRSEERRKWFEATDSRTPEVPAGEGPRRGLGAPLTEDQQNRLSEEIEKKWQELEKLPLRENKRVPLTALLNQSRGERRGPPSDGHEALEKEVQALRAQLEAWRLQGEAPQSALRSQEDGHIPPGYISQEACERSLAEMESSHQQVMEELQRHHERELQRLQQEKEWLLAEETAATASAIEAMKKAYQEELSRELSKTRSLQQGPDGLRKQHQSDVEALKRELQVLSEQYSQKCLEIGALMRQAEEREHTLRRCQQEGQELLRHNQELHGRLSEEIDQLRGFIASQGMGNGCGRSNERSSCELEVLLRVKENELQYLKKEVQCLRDELQMMQKDKRFTSGKYQDVYVELSHIKTRSEREIEQLKEHLRLAMAALQEKESMRNSLAE", "length": 2365 }, "evidence": [ { "id": "45236255", "url": "http://www.informatics.jax.org/homology/45236255", "database": "MGI" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "actin cytoskeleton", "id": "GO:0015629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015629", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K1P8", "url": "https://www.uniprot.org/uniprot/A0A0G2K1P8" } ], "pmid": "" }, { "name": "stereocilium", "id": "GO:0032420", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032420", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K1P8", "url": "https://www.uniprot.org/uniprot/A0A0G2K1P8" } ], "pmid": "" }, { "name": "stereocilium base", "id": "GO:0120044", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0120044", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K1P8", "url": "https://www.uniprot.org/uniprot/A0A0G2K1P8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "actin filament binding", "id": "GO:0051015", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051015", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K1P8", "url": "https://www.uniprot.org/uniprot/A0A0G2K1P8" } ], "pmid": "" }, { "name": "ubiquitin protein ligase binding", "id": "GO:0031625", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031625", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K1P8", "url": "https://www.uniprot.org/uniprot/A0A0G2K1P8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "positive regulation of substrate adhesion-dependent cell spreading", "id": "GO:1900026", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1900026", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K1P8", "url": "https://www.uniprot.org/uniprot/A0A0G2K1P8" } ], "pmid": "" }, { "name": "sensory perception of sound", "id": "GO:0007605", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007605", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K1P8", "url": "https://www.uniprot.org/uniprot/A0A0G2K1P8" } ], "pmid": "" }, { "name": "auditory receptor cell stereocilium organization", "id": "GO:0060088", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060088", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K1P8", "url": "https://www.uniprot.org/uniprot/A0A0G2K1P8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 133, "end_pos": 135, "annotation": "n_glycosylation_sequon" }, { "start_pos": 148, "end_pos": 150, "annotation": "n_glycosylation_sequon" }, { "start_pos": 350, "end_pos": 352, "annotation": "n_glycosylation_sequon" }, { "start_pos": 374, "end_pos": 376, "annotation": "n_glycosylation_sequon" }, { "start_pos": 398, "end_pos": 400, "annotation": "n_glycosylation_sequon" }, { "start_pos": 446, "end_pos": 448, "annotation": "n_glycosylation_sequon" }, { "start_pos": 470, "end_pos": 472, "annotation": "n_glycosylation_sequon" }, { "start_pos": 494, "end_pos": 496, "annotation": "n_glycosylation_sequon" }, { "start_pos": 768, "end_pos": 770, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": 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"count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }