{ "uniprot_canonical_ac": "A6KTC8-1", "uniprot_ac": "A6KTC8", "uniprot_id": "A6KTC8_RAT", "mass": { "chemical_mass": 103408.0, "monoisotopic_mass": 103408.0 }, "refseq": { "ac": "NP_001040561", "name": "polyphosphoinositide phosphatase", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040561" }, "gene_names": [ { "name": "Fig4", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A6KTC8", "id": "A6KTC8" }, { "name": "Fig4", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040561", "id": "NP_001040561" }, { "name": "Kiaa0274; RGD1311375; Sac3", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040561", "id": "NP_001040561" }, { "name": "Sac3", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A6KTC8", "id": "A6KTC8" } ], "protein_names": [ { "name": "FIG4 phosphoinositide 5-phosphatase", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A6KTC8/entry#names_and_taxonomy", "id": "A6KTC8" }, { "name": "SAC3", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A6KTC8/entry#names_and_taxonomy", "id": "A6KTC8" }, { "name": "Sac domain-containing inositol phosphatase 3", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040561", "id": "NP_001040561" }, { "name": "polyphosphoinositide phosphatase", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040561", "id": "NP_001040561" } ], "function": [], "disease": [ { "disease_id": "DOID:0060202", "recommended_name": { "id": "DOID:0060202", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0060202", "name": "amyotrophic lateral sclerosis type 11", "description": "An amyotrophic lateral sclerosis that has_material_basis_in mutation in the FIG4 gene on chromosome 6." }, "synonyms": [ { "id": "DOID:0060202", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0060202", "name": "ALS11", "description": "" }, { "id": "DOID:0060202", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0060202", "name": "amyotrophic lateral sclerosis 11", "description": "" }, { "id": "MONDO:0012945", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012945", "name": "amyotrophic lateral sclerosis type 11", "description": "Any amyotrophic lateral sclerosis in which the cause of the disease is a mutation in the FIG4 gene." }, { "id": "MONDO:0012945", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012945", "name": "ALS11", "description": "" }, { "id": "MONDO:0012945", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012945", "name": "FIG4 amyotrophic lateral sclerosis", "description": "" }, { "id": "MONDO:0012945", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012945", "name": "amyotrophic lateral sclerosis 11", "description": "" }, { "id": "MONDO:0012945", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012945", "name": "amyotrophic lateral sclerosis caused by mutation in FIG4", "description": "" }, { "id": "MONDO:0012945", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012945", "name": "amyotrophic lateral sclerosis type 11", "description": "" }, { "id": "MIM:612577", "resource": "MIM", "url": "https://www.omim.org/entry/612577", "name": "Amyotrophic lateral sclerosis 11", "description": "Amyotrophic lateral sclerosis 11" } ], "evidence": [ { "id": "0060202", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0060202" } ] }, { "disease_id": "DOID:0060589", "recommended_name": { "id": "DOID:0060589", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0060589", "name": "Yunis-Varon syndrome", "description": "A syndrome characterized by skeletal defects, including cleidocranial dysplasia and digital anomalies, and severe neurologic involvement with neuronal loss. Enlarged cytoplasmic vacuoles are found in neurons, muscle, and cartilage. It is usually lethal in infancy and has_material_basis_in homozygous or compound heterozygous mutation in the FIG4 gene on chromosome 6q21." }, "synonyms": [ { "id": "DOID:0060589", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0060589", "name": "cleidocranial dysplasia-micrognathia-absent thumbs syndrome", "description": "" }, { "id": "DOID:0060589", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0060589", "name": "cleidocranial dysplasia with micrognathia, absent thumbs, and distal aphalangia", "description": "" }, { "id": "MONDO:0008995", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008995", "name": "Yunis-Varon syndrome", "description": "Yunis-Varon syndrome is a rare condition that affects many different parts of the body. Signs and symptoms are generally present from birth and may include underdeveloped or absent collarbones (clavicles); large fontanelles; characteristic facial features; hypotonia (reduced muscle tone) and/or abnormalities of the fingers and toes. Affected people may also experience feeding difficulties, breathing problems, brain malformations, heart defects, skeletal abnormalities, developmental delay, and/or intellectual disability. Yunis-Varon syndrome is caused by changes (mutations) in the FIG4 gene and isinherited in an autosomal recessive manner. Treatment is based on the signs and symptoms present in each person." }, { "id": "MONDO:0008995", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008995", "name": "Yunis Varon Syndrome", "description": "" }, { "id": "MONDO:0008995", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008995", "name": "Yunis Varon syndrome", "description": "" }, { "id": "MONDO:0008995", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008995", "name": "Yunis-Varon syndrome", "description": "" }, { "id": "MONDO:0008995", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008995", "name": "Yunis-Varn syndrome", "description": "" }, { "id": "MONDO:0008995", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008995", "name": "cleidocranial dysplasia with micrognathia, absent thumbs, and distal aphalangia", "description": "" }, { "id": "MONDO:0008995", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008995", "name": "cleidocranial dysplasia-micrognathia-absent thumbs syndrome", "description": "" }, { "id": "MONDO:0008995", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008995", "name": "YVS", "description": "" }, { "id": "MONDO:0008995", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008995", "name": "cleidocranial dysplasia with micrognathia, absent thumbs, and distal Aphalangia", "description": "" }, { "id": "MIM:216340", "resource": "MIM", "url": "https://www.omim.org/entry/216340", "name": "Yunis-Varon syndrome", "description": "Yunis-Varon syndrome" } ], "evidence": [ { "id": "0060589", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0060589" } ] }, { "disease_id": "DOID:0080923", "recommended_name": { "id": "DOID:0080923", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0080923", "name": "bilateral parasagittal parieto-occipital polymicrogyria", "description": "A polymicrogyria that is characterized by bilateral malformation of cortical development, centered around the parasagittal and mesial aspects of the parietooccipital cortex and that has_material_basis_in homozygous mutation in the FIG4 gene on chromosome 6q21." }, "synonyms": [ { "id": "DOID:0080923", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0080923", "name": "bilateral temporooccipital polymicrogyria", "description": "" }, { "id": "MONDO:0012986", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012986", "name": "bilateral parasagittal parieto-occipital polymicrogyria", "description": "" }, { "id": "MONDO:0012986", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012986", "name": "BTOP", "description": "" }, { "id": "MONDO:0012986", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012986", "name": "polymicrogyria, bilateral temporooccipital", "description": "" }, { "id": "MIM:612691", "resource": "MIM", "url": "https://www.omim.org/entry/612691", "name": "Polymicrogyria, bilateral temporooccipital", "description": "Polymicrogyria, bilateral temporooccipital" } ], "evidence": [ { "id": "0080923", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0080923" } ] }, { "disease_id": "DOID:0110184", "recommended_name": { "id": "DOID:0110184", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110184", "name": "Charcot-Marie-Tooth disease type 4J", "description": "A Charcot-Marie-Tooth disease type 4 that has_material_basis_in compound heterozygous mutations in the FIG4 gene on chromosome 6q21." }, "synonyms": [ { "id": "DOID:0110184", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110184", "name": "CMT4J", "description": "" }, { "id": "DOID:0110184", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110184", "name": "autosomal recessive Charcot-Marie-Tooth disease type 4J", "description": "" }, { "id": "MONDO:0012640", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012640", "name": "Charcot-Marie-Tooth disease type 4J", "description": "Charcot-Marie-Tooth disease, type 4J (CMT4J) belongs to the genetically heterogeneous group of CMT peripheral sensorimotor polyneuropathy diseases." }, { "id": "MONDO:0012640", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012640", "name": "CMT4J", "description": "" }, { "id": "MONDO:0012640", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012640", "name": "Charcot-Marie-Tooth disease type 4 caused by mutation in FIG4", "description": "" }, { "id": "MONDO:0012640", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012640", "name": "FIG4 Charcot-Marie-Tooth disease type 4", "description": "" }, { "id": "MONDO:0012640", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012640", "name": "autosomal recessive Charcot-Marie-Tooth disease type 4J", "description": "" }, { "id": "MONDO:0012640", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012640", "name": "Charcot-Marie-Tooth disease, autosomal recessive, type 4J", "description": "" }, { "id": "MONDO:0012640", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012640", "name": "Charcot-Marie-Tooth disease, type 4J", "description": "" }, { "id": "MIM:611228", "resource": "MIM", "url": "https://www.omim.org/entry/611228", "name": "Charcot-Marie-Tooth disease 4J", "description": "Charcot-Marie-Tooth disease 4J" } ], "evidence": [ { "id": "0110184", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0110184" } ] }, { "disease_id": "DOID:10595", "recommended_name": { "id": "DOID:10595", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10595", "name": "Charcot-Marie-Tooth disease", "description": "A neuromuscular disease that is characterized by a slowly progressive degeneration of the muscles of the foot, lower leg, hand and forearm." }, "synonyms": [ { "id": "DOID:10595", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10595", "name": "CMT - Charcot-Marie-Tooth disease", "description": "" }, { "id": "MONDO:0007309", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007309", "name": "Charcot-Marie-Tooth disease type 1A", "description": "Charcot-Marie-Tooth disease type 1A (CMT1A) is a type ofinherited neurological disorder that affects the peripheral nerves. Affected individuals experience weakness and wasting (atrophy) of the muscles of the lower legs beginning in adolescence; later they experience hand weakness and sensory loss. CMT1A is caused byhaving an extra copy (a duplication) of the PMP22 gene. It is inherited in an autosomal dominant manner. Treatment for this condition may include physical therapy ; occupational therapy ; braces and other orthopedic devices; orthopedic surgery;and pain medications." }, { "id": "MONDO:0007309", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007309", "name": "CMT1A", "description": "" }, { "id": "MONDO:0007309", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007309", "name": "Charcot-Marie-Tooth disease type 1A", "description": "" }, { "id": "MONDO:0007309", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007309", "name": "Charcot-Marie-Tooth disease, type 1A", "description": "" }, { "id": "MONDO:0007309", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007309", "name": "Charcot-Marie-Tooth neuropathy type 1A", "description": "" }, { "id": "MONDO:0007309", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007309", "name": "Charcot-Marie-Tooth syndrome type 1A", "description": "" }, { "id": "MONDO:0007309", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007309", "name": "HMSN1A", "description": "" }, { "id": "MONDO:0007309", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007309", "name": "autosomal dominant Charcot-Marie-Tooth disease with focally folded myelin sheaths type 1A", "description": "" }, { "id": "MONDO:0007309", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007309", "name": "hereditary motor and sensory neuropathy 1A", "description": "" }, { "id": "MONDO:0007309", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007309", "name": "microduplication 17p12", "description": "" }, { "id": "MONDO:0007309", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007309", "name": "CMT 1A", "description": "" }, { "id": "MONDO:0007309", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007309", "name": "Charcot Marie Tooth disease type 1A", "description": "" }, { "id": "MONDO:0007309", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007309", "name": "Charcot-Marie-Tooth disease, autosomal dominant, with focally folded myelin sheaths, type 1A", "description": "" }, { "id": "MONDO:0007309", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007309", "name": "Charcot-Marie-Tooth disease, demyelinating, type 1A", "description": "" }, { "id": "MONDO:0007309", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007309", "name": "Charcot-Marie-Tooth neuropathy, type 1A", "description": "" }, { "id": "MONDO:0007309", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007309", "name": "HMSN 1A", "description": "" }, { "id": "MIM:118220", "resource": "MIM", "url": "https://www.omim.org/entry/118220", "name": "Charcot-Marie-Tooth disease, demyelinating, 1A", "description": "Charcot-Marie-Tooth disease, demyelinating, 1A" } ], "evidence": [ { "id": "10595", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:10595" } ] }, { "disease_id": "DOID:1289", "recommended_name": { "id": "DOID:1289", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1289", "name": "neurodegenerative disease", "description": "A central nervous system disease that results in the progressive deterioration of function or structure of neurons." }, "synonyms": [ { "id": "DOID:1289", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1289", "name": "degenerative disease", "description": "" } ], "evidence": [ { "id": "1289", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:1289" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "A6KTC8", "url": "https://www.uniprot.org/uniprot/A6KTC8" } ], "common_name": "Rat", "glygen_name": "Rat", "reference_species": "Rattus norvegicus [10116]" } ], "gene": [ { "name": "Fig4", "url": "https://www.uniprot.org/uniprot/A6KTC8", "locus": { "chromosome": "20", "start_pos": 44600603, "end_pos": 44723844, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000000312", "url": "https://www.ensembl.org/id/ENSRNOG00000000312" } ] } } ], "crossref": [ { "id": "ENSRNOG00000000312", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000000312", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "309855", "url": "https://www.ncbi.nlm.nih.gov/gene/309855", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002013", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002013", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043573", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043573", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "rno:309855", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:309855", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "KRKCCAH", "url": "https://omabrowser.org/oma/group/KRKCCAH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "996872at2759", "url": "http://www.orthodb.org/?query=996872at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45738", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45738", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45738:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45738:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02383", "url": "http://pfam.xfam.org/family/PF02383", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "NP_001040561", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040561", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "1311375", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1311375", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "A0A8I6ADY9", "url": "https://www.uniprot.org/uniprot/A0A8I6ADY9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6ADY9-1", "url": "https://www.uniprot.org/uniprot/A0A8I6ADY9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A6KTC8", "url": "https://www.uniprot.org/uniprot/A6KTC8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A6KTC8-1", "url": "https://www.uniprot.org/uniprot/A6KTC8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPTAAAPIISSVQKLVLYETRARYFLVGSNHAETKFRVLKIDRTEPKDLVVIDDRHVYTQQEVRELLGRLDLGNRTKLSQKGSSGLFRAVSAFGVVGFVRFLEGYYIVLITKRRKMADIGGHAIYKIEDTSMIYIPNDSVRITHPDEARYLRIFQNVDLSSNFYFSYSYDLSHSLQYNLTVLRMPLEMLKSETSKTCQESFDIFEDEGLTTQGGSGVFGISSEPYMKYVWNGELLDIIKNSVHRDWLLYIIHGFCGQSKLLIYGRPVYVTLIARRSSRFAGTRFLKRGANCEGDVANEVETEQILCDASVMSFTAGSYSSYVQVRGSVPLFWSQDISTMMPKPPITLDQADPFAHIAALHFDQMLQRFGSPIIILNLVKEREKRKHERILSEELVAAVTYLNQFLPPEHSIVYIPWDMAKYTKSKLCNVLDRLNVIAESVVKKTGFFVNRPDSYCSVLRPDEKWNELGGRVIPTGRLQTGILRTNCVDCLDRTNTAQFMVGKCALAYQLYSLGLIDKPNLQFDTDAVRLFEELYEDHGDTLSLQYGGSQLVHRVKTYRKIAPWTQHSKDIMQTLSRYYSNAFSDADRQDSINLFLGVFHPTEGKPHLWELPTDFYLHHKNTMSLLPPKRSYTHWWTPEVVKHLPLPYDEVICAANLKKLTVKKFHRWEEEIDIHNEFFRPYELSSFDDTFCLAMTSSARDFMPKTIGIDPSPFTVRKPDETGKSVLGNKSNREEAVLQRKTAASAPPPPSEEAVSSSSEDDSGTDREDEGSISQRSTPVKMTDTGDSAKVTESVAQPMKEVYGVSLSRSLSEEDHSIYARFVQLGQSQHRQDWSSPQMCARCSDGVIKLTPISAFSQDNIYEVQPPRVDRKSTEIFQAHIQASQGIMQPLGKEDTAIYREYIRNRYL", "length": 907, "header": "tr|A6KTC8-1|A6KTC8_RAT Isoform 1 of SAC3 OS=Rattus norvegicus OX=10116 GN=Fig4 PE=1 SV=1 CANONICAL=A6KTC8-1" }, "isoforms": [ { "isoform_ac": "A0A8I6ADY9-1", "url": "https://www.uniprot.org/uniprotkb/A6KTC8/entry#A0A8I6ADY9-1", "sequence": { "sequence": "MPTAAAPIISSVQKLVLYETRARYFLVGSNHAETKFRVLKIDRTEPKDLVVIDDRHVYTQQEVRELLGRLDLGNRTKLSQKGSSGLFRAVSAFGVVGFVRFLEGYYIVLITKRRKMADIGGHAIYKIEDTSMIYIPNDSVRITHPDEARYVYSYDLSHSLQYNLTVLRMPLEMLKSETSKTCQESFDIFEDEGLTTQGGSGVFGISSEPYMKYVWNGELLDIIKNSVHRDWLLYIIHGFCGQSKLLIYGRPVYVTLIARRSSRFAGTRFLKRGANCEGDVANEVETEQILCDASVMSFTAGSYSSYVQVRGSVPLFWSQDISTMMPKPPITLDQADPFAHIAALHFDQMLQRFGSPIIILNLVKEREKRKHERILSEELVAAVTYLNQFLPPEHSIVYIPWDMAKYTKSKLCNVLDRLNVIAESVVKKTGFFVNRPDSYCSVLRPDEKGISLWSEVAQTGILRTNCVDCLDRTNTAQFMVGKCALAYQLYSLGLIDKPNLQFDTDAVRLFEELYEDHGDTLSLQYGGSQLVHRVKTYRKIAPWTQHSKDIMQTLSRYYSNAFSDADRQDSINLFLGVFHPTEGKPHLWELPTDFYLHHKNTMSLLPPKRSYTHWWTPEVVKHLPLPYDEVICAANLKKLTVKKFHRWEEEIDIHNEFFRPYELSSFDDTFCLAMTSSARDFMPKTIGIDPSPFTVRKPDETGKSVLGNKSNREEAVLQRKTAASAPPPPSEEAVSSSSEDDSGTDREDEGSISQRSTPVKMTDTGDSAKVTESVAQPMKEVYGVSLSRSLSEEDHSIYARFVQLGQSQHRQDWSSPQMCARCSDGVIKLTPISAFSQDNIYEVQPPRVDRKSTEIFQAHIQASQGIMQPLGKEDTAIYREYIRNRYL", "length": 887, "header": "tr|A0A8I6ADY9-1|A0A8I6ADY9_RAT Computationally mapped isoform of FIG4 phosphoinositide 5-phosphatase OS=Rattus norvegicus OX=10116 GN=Fig4 PE=1 SV=1 CANONICAL=A6KTC8-1" }, "locus": { "chromosome": "20", "start_pos": 44723841, "end_pos": 44601019, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000101588.1", "url": "https://www.ensembl.org/id/ENSRNOT00000101588.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000091577.1", "url": "https://www.ensembl.org/id/ENSRNOP00000091577.1" } ] } }, { "isoform_ac": "A6KTC8-1", "url": "https://www.uniprot.org/uniprotkb/A6KTC8/entry#A6KTC8-1", "sequence": { "sequence": "MPTAAAPIISSVQKLVLYETRARYFLVGSNHAETKFRVLKIDRTEPKDLVVIDDRHVYTQQEVRELLGRLDLGNRTKLSQKGSSGLFRAVSAFGVVGFVRFLEGYYIVLITKRRKMADIGGHAIYKIEDTSMIYIPNDSVRITHPDEARYLRIFQNVDLSSNFYFSYSYDLSHSLQYNLTVLRMPLEMLKSETSKTCQESFDIFEDEGLTTQGGSGVFGISSEPYMKYVWNGELLDIIKNSVHRDWLLYIIHGFCGQSKLLIYGRPVYVTLIARRSSRFAGTRFLKRGANCEGDVANEVETEQILCDASVMSFTAGSYSSYVQVRGSVPLFWSQDISTMMPKPPITLDQADPFAHIAALHFDQMLQRFGSPIIILNLVKEREKRKHERILSEELVAAVTYLNQFLPPEHSIVYIPWDMAKYTKSKLCNVLDRLNVIAESVVKKTGFFVNRPDSYCSVLRPDEKWNELGGRVIPTGRLQTGILRTNCVDCLDRTNTAQFMVGKCALAYQLYSLGLIDKPNLQFDTDAVRLFEELYEDHGDTLSLQYGGSQLVHRVKTYRKIAPWTQHSKDIMQTLSRYYSNAFSDADRQDSINLFLGVFHPTEGKPHLWELPTDFYLHHKNTMSLLPPKRSYTHWWTPEVVKHLPLPYDEVICAANLKKLTVKKFHRWEEEIDIHNEFFRPYELSSFDDTFCLAMTSSARDFMPKTIGIDPSPFTVRKPDETGKSVLGNKSNREEAVLQRKTAASAPPPPSEEAVSSSSEDDSGTDREDEGSISQRSTPVKMTDTGDSAKVTESVAQPMKEVYGVSLSRSLSEEDHSIYARFVQLGQSQHRQDWSSPQMCARCSDGVIKLTPISAFSQDNIYEVQPPRVDRKSTEIFQAHIQASQGIMQPLGKEDTAIYREYIRNRYL", "length": 907, "header": "tr|A6KTC8-1|A6KTC8_RAT Isoform 1 of SAC3 OS=Rattus norvegicus OX=10116 GN=Fig4 PE=1 SV=1 CANONICAL=A6KTC8-1" }, "locus": { "chromosome": "20", "start_pos": 44723841, "end_pos": 44601019, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000000343.5", "url": "https://www.ensembl.org/id/ENSRNOT00000000343.5" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000000343.2", "url": "https://www.ensembl.org/id/ENSRNOP00000000343.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "rSac3, a novel Sac domain phosphoinositide phosphatase, promotes neurite outgrowth in PC12 cells.", "journal": "Cell Res.", "date": "2007", "authors": "Yuan Yiyuan, Gao Xiang, Guo Ning, Zhang Hui, Xie Zhiqin, Jin Meilei, Li Baoming, Yu Lei, Jing Naihe", "evidence": [ { "database": "UniProtKB", "id": "A6KTC8", "url": "https://www.uniprot.org/uniprot/A6KTC8" } ], "reference": [ { "type": "PubMed", "id": "17909536", "url": "https://glygen.org/publication/PubMed/17909536" } ] } ], "pathway": [ { "id": "rno:309855", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:309855", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0YGB7-1", "protein_name": "FIG4 phosphoinositide 5-phosphatase", "gene_name": "FIG4", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MPAAAAAPLISSVQKLVLYETRARYFLVGSNPAETKYRVLKIDRTEPKDLVIIDDKHVYTQQEVRELLGRLDLGNRTKIGQKGSSGLSRAVSAFGIVGFIRFLEGYYIVLITKRRKMADIGGHAIYKIEDTNMIYIPNDSVRVTHPDEARYLRIFQNVDLSSNFYFSYSYDLSHSLQYNLTVLRMPLEILKTETTQTRQESFDIFEDEGLSTQGGSGVFGICSKPYEKYVWNGKLLEAVKNTVHHDWLLYIIHGFCGQSKLLIYGRPIYVTLIARRSSKFAGTRFLKRGSNSEGDVANEVETEQILYDASVMSFSAGSYSSYVQVRGSVPLYWSQDISTMMPKPPITLDQADPFAHIAALHFDQMLQRFGSPIIILNLVKEREKRKHERILSEELVAAVTYLNQFLPPEHAIIYIPWDMAKYTKSKLCNVLDRLNVIAESVVKKTGFFVNRPDSYCNVLRPDEKWNELGGCVVSTGRLQTGVLRTNCVDCLDRTNTAQFMVGKCALAYQLYSLGLIDKPNLQFDTDAVRLFEELYEDHGDTLSLQYGGSQLVHRVKTYRKIAPWTQHSKDIMQTLSRYYSNAFSDADRQESINLFLGVFKPVEGKPHLWELPTDFYLHHKNTLSLSQTRRSYTYWWTTGVLKHLPLPFDEVTCAENRRKLTVKKFHKYEEEIDIHNEFFRPYELSSFDETFCLAMTNSTRDFMPKNVGIDPSPFTVRKPDETGKSVLGNKSNREETVLQRKTAASAPPPPSEEAVSSSSEDDSGTDKEDEGAVSQRSTPVKVTDAGDNTKITENVVQSTKDVYGVNLSDVPSEDDITIYARFVQLGQSQHKQDKSSQQFCSKHQLDRVINLIPISSFSQDNIYEVQPPRADRKSIEIFHAHIQAGKGNMQPLGKDDFLMYREYIRNRYL", "length": 909 }, "evidence": [ { "id": "A6KTC8", "url": "https://omabrowser.org/oma/group/A6KTC8/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "P42837-1", "protein_name": "Polyphosphoinositide phosphatase", "gene_name": "FIG4", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MNNDAMEHTLGGGILTTSGSKQRKTSKFVMGKYTLYETKDRMYIVGSNKRETMFRILEIDLTVPRGELTVLEDNVFFTRNEIMNVLASLEEATEDGLHKKITGYGLLGFIKFTCWYYLIMVTKYSQVAVIGGHGIYHIDGIDIIPITNNYKKPEKSSDEARLLNIFKDLDLTKTFYFSYTYDITNTLQTNILREKLKAVDRCDITIPCGITDYNEMFVWNNNLLSPIFACIDTVFDWFQCIIHGFIDQVNVSVLGKSIYITLIARRSHHFAGARFLKRGVNNKGHVANEVETEQIVTDMILTPFHQPGNGFFDSDRYTSFVQHRGSIPLYWTQDASNLTTKPPIRINVVDPFFSPAALHFDNLFQRYGGGTIQILNLIKTKEKTPRETKLLWEFEQCIDYLNEFLPTLKKLDYTSWDMSRASKQDGQGVIEFLEKYAVNTVTTTGIFHNGPDFASTKIQEGICRSNCIDCLDRTNAAQFVIGKRALGCQLKSLGIIDNSYLEYDSDIVNILTELFHDLGDTIALQYGGSHLVNTMETYRKINQWSSHSRDMIESIKRFYSNSFVDAQRQDAINLFLGHYSWREGFPSLWEMNTDFYLHNAYSLNMPKRSYIHWWNDYNIKSVKELINEELIATGNDVTREKIIKNVRGYPGAFDNYWNEYYLPRSVTWIRDLFAYNMNSTRRYHNALSKQDKAMSPFTSRKQSWLNNKLKMITSSKSLEKAEGRVVETTDLDRDTSPKQELELYEHYLHIISDRSQKLEEKMNSFSYSKYPIFISHESSEIPPMRKVIGEPLVDIAEDFTDVYDDDDDGDDENDEMTTEALLIAPDHVSVDEKFYEKVLNVDDYKPALDDYSAVIHIKPDNLQLYRDLCFSKDIQLDFQ", "length": 879 }, "evidence": [ { "id": "A6KTC8", "url": "https://omabrowser.org/oma/group/A6KTC8/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q91WF7-1", "protein_name": "Polyphosphoinositide phosphatase", "gene_name": "Fig4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPTAAAPIISSVQKLVLYETRARYFLVGSNHAETKYRVLKIDRTEPKDLVVIDDRHVYTQQEVRELLGRLDLGNRTKMSQKGSSGLFRAVSAFGVVGFVRFLEGYYIVLITKRRKMADIGGHAIYKIEDTSMIYIPNDSVRISHPDEARYLRIFQNVDLSSNFYFSYSYDLSHSLQYNLTVLRMPLEMLKSETSKACQESFDIFEDEGLITQGGSGVFGISSEPYMKYVWNGELLDIIKNTVHRDWLLYIIHGFCGQSKLLIYGRPVYVTLIARRSSRFAGTRFLKRGANCEGDVANEVETEQILCDASVMSFTAGSYSSYVQVRGSVPLFWSQDISTMMPKPPITLDQADPFAHVAALHFDQMLQRFGSPIIILNLVKEREKRKHERILSEELVAAVTYLNQFLPPEHTIVYIPWDMAKYTKSKLCNVLDRLNVIAESVVKKTGFFVNRPDSYCSILRPDEKWNELGGHVIPTGRLQTGILRTNCVDCLDRTNTAQFMVGKCALAYQLYSLGLIDKPNLQFDTDAVRLFEELYEDHGDTLSLQYGGSQLVHRVKTYRKIAPWTQHSKDIMQTLSRYYSNAFSDADRQDSINLFLGVFHPTEGKPHLWELPTDFYLHHKNTMSLLPPRRSYTYWWTPEVVKHLPLPYDEVICAANLKKLMVKKFHRWEEEIDIHNEFFRPYELSSFDDTFCLAMTSSARDFMPKTVGIDPSPFTVRKPDETGKSVLGNKNTREEAVLQRKTAASAPPPPSEEAVSSSSEDDSGTDREDEGSISQRSTPVKMTDTGDSAKATENVVQPMKEVYGVSLSSSLSEEDHSIYARFVQLGQSQHKQDRGNQQLCSRCSDGVIKLTPISAFSQDNIYEVQPPRVDRKSTEIFQAHIQASQGIMQPLGKEDTAMYREYIRNRYL", "length": 907 }, "evidence": [ { "id": "46371182", "url": "http://www.informatics.jax.org/homology/46371182", "database": "MGI" }, { "id": "A6KTC8", "url": "https://omabrowser.org/oma/group/A6KTC8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q92562-1", "protein_name": "Polyphosphoinositide phosphatase", "gene_name": "FIG4", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPTAAAPIISSVQKLVLYETRARYFLVGSNNAETKYRVLKIDRTEPKDLVIIDDRHVYTQQEVRELLGRLDLGNRTKMGQKGSSGLFRAVSAFGVVGFVRFLEGYYIVLITKRRKMADIGGHAIYKVEDTNMIYIPNDSVRVTHPDEARYLRIFQNVDLSSNFYFSYSYDLSHSLQYNLTVLRMPLEMLKSEMTQNRQESFDIFEDEGLITQGGSGVFGICSEPYMKYVWNGELLDIIKSTVHRDWLLYIIHGFCGQSKLLIYGRPVYVTLIARRSSKFAGTRFLKRGANCEGDVANEVETEQILCDASVMSFTAGSYSSYVQVRGSVPLYWSQDISTMMPKPPITLDQADPFAHVAALHFDQMFQRFGSPIIILNLVKEREKRKHERILSEELVAAVTYLNQFLPPEHTIVYIPWDMAKYTKSKLCNVLDRLNVIAESVVKKTGFFVNRPDSYCSILRPDEKWNELGGCVIPTGRLQTGILRTNCVDCLDRTNTAQFMVGKCALAYQLYSLGLIDKPNLQFDTDAVRLFEELYEDHGDTLSLQYGGSQLVHRVKTYRKIAPWTQHSKDIMQTLSRYYSNAFSDADRQDSINLFLGVFHPTEGKPHLWELPTDFYLHHKNTMRLLPTRRSYTYWWTPEVIKHLPLPYDEVICAVNLKKLIVKKFHKYEEEIDIHNEFFRPYELSSFDDTFCLAMTSSARDFMPKTVGIDPSPFTVRKPDETGKSVLGNKSNREEAVLQRKTAASAPPPPSEEAVSSSSEDDSGTDREEEGSVSQRSTPVKMTDAGDSAKVTENVVQPMKELYGINLSDGLSEEDFSIYSRFVQLGQSQHKQDKNSQQPCSRCSDGVIKLTPISAFSQDNIYEVQPPRVDRKSTEIFQAHIQASQGIMQPLGKEDSSMYREYIRNRYL", "length": 907 }, "evidence": [ { "id": "46371182", "url": "http://www.informatics.jax.org/homology/46371182", "database": "MGI" }, { "id": "A6KTC8", "url": "https://omabrowser.org/oma/group/A6KTC8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9VR06-1", "protein_name": "LD46494p", "gene_name": "FIG4", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MNNDNPNIVFNPLISSIQKVVLYETRARLYLVGSNNRETRFRLLTIDRLAHNRLSIEENANEFNSLEIRRFVASLSGSPKVTSAYGVLGFVRFLEGYYLLLVTKRKCCAHIGRHLVYTIKDTVMVRVNEVTSQRPPHPHEDRYKRMFQNIDLRSNFYFSYSYDLTRTLQYNESAPRYVGAKVDLDRDEPLPDWNTLTSNVDKAHERVDYAFRSDSRKRFVWNAYLLQPMEGIMLKDWLLEVTHGFVSQSCISIFGRHVNVCLVARRSSRFAGTRFLKRGANFQGDVANEVETEQIVSDGQRICAFTQMRGSIPSHWSQDISKMVPKPQIQLDICDPYAQTPSLHFERLLFHYGAPLIMLNLVKKRERRKHESIISKELEYSIRYLNQFLPPPHRMKHIHFDMARQSRLSGGNVMEQLAIHAESIVQMTGMFFKAAGSEPGLQTGIVRTNCVDCLDRTNSAQFAIGKCALGHQLERLGFVKSAKLEFDSDCVTMLENLYEEHGDTLALQYGGSQLVHRIKTYRKTAPWGSQGSDVMQTLSRYYSNTFSDTEKQHSINLFLGIYKPSLTKQGPPIWELQTDYDMHNAFVPRADSKAITDWVRHKVRACLPYSCADSNKLVKELFRVHSSGLEMIDAYSNYHQSFKWTDFSEHIAFEISQLALRYMPTFRTNFSPFQRQIQTSRKARQNPSMTGQSSTGSMNSNSSSSSEGDDSSSDEELSASFAEKEANQTESTEPAAATLATGLPSMEEIYGCTINPPSKQSMAVYKKYVQMGKLSSGGARPAQTAVAQRDQELAKIMRGITLRPLSDYGTDSYLSVRPPVVPRKSLTIYAEYCRTRSTFNAVPKLEEFDVLYQYVQKL", "length": 858 }, "evidence": [ { "id": "A6KTC8", "url": "https://omabrowser.org/oma/group/A6KTC8/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "phosphatidylinositol bisphosphate phosphatase activity", "id": "GO:0034593", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034593", "evidence": [ { "database": "UniProtKB", "id": "A6KTC8", "url": "https://www.uniprot.org/uniprot/A6KTC8" } ], "pmid": "" }, { "name": "phosphatidylinositol-3-phosphate phosphatase activity", "id": "GO:0004438", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004438", "evidence": [ { "database": "UniProtKB", "id": "A6KTC8", "url": "https://www.uniprot.org/uniprot/A6KTC8" } ], "pmid": "" }, { "name": "phosphatidylinositol-4-phosphate phosphatase activity", "id": "GO:0043812", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043812", "evidence": [ { "database": "UniProtKB", "id": "A6KTC8", "url": "https://www.uniprot.org/uniprot/A6KTC8" } ], "pmid": "" }, { "name": "phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity", "id": "GO:0043813", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043813", "evidence": [ { "database": "UniProtKB", "id": "A6KTC8", "url": "https://www.uniprot.org/uniprot/A6KTC8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 10, "go_terms": [ { "name": "locomotory behavior", "id": "GO:0007626", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007626", "evidence": [ { "database": "UniProtKB", "id": "A6KTC8", "url": "https://www.uniprot.org/uniprot/A6KTC8" } ], "pmid": "" }, { "name": "positive regulation of neuron projection development", "id": "GO:0010976", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010976", "evidence": [ { "database": "UniProtKB", "id": "A6KTC8", "url": "https://www.uniprot.org/uniprot/A6KTC8" } ], "pmid": "" }, { "name": "myelination", "id": "GO:0042552", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042552", "evidence": [ { "database": "UniProtKB", "id": "A6KTC8", "url": "https://www.uniprot.org/uniprot/A6KTC8" } ], "pmid": "" }, { "name": "neuron development", "id": "GO:0048666", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048666", "evidence": [ { "database": "UniProtKB", "id": "A6KTC8", "url": "https://www.uniprot.org/uniprot/A6KTC8" } ], "pmid": "" }, { "name": "pigmentation", "id": "GO:0043473", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043473", "evidence": [ { "database": "UniProtKB", "id": "A6KTC8", "url": "https://www.uniprot.org/uniprot/A6KTC8" } ], "pmid": "" }, { "name": "vacuole organization", "id": "GO:0007033", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007033", "evidence": [ { "database": "UniProtKB", "id": "A6KTC8", "url": "https://www.uniprot.org/uniprot/A6KTC8" } ], "pmid": "" }, { "name": "phosphatidylinositol dephosphorylation", "id": "GO:0046856", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046856", "evidence": [ { "database": "UniProtKB", "id": "A6KTC8", "url": "https://www.uniprot.org/uniprot/A6KTC8" } ], "pmid": "" }, { "name": "phosphatidylinositol metabolic process", "id": "GO:0046488", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046488", "evidence": [ { "database": "UniProtKB", "id": "A6KTC8", "url": "https://www.uniprot.org/uniprot/A6KTC8" } ], "pmid": "" }, { "name": "myelin assembly", "id": "GO:0032288", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032288", "evidence": [ { "database": "UniProtKB", "id": "A6KTC8", "url": "https://www.uniprot.org/uniprot/A6KTC8" } ], "pmid": "" }, { "name": "negative regulation of myelination", "id": "GO:0031642", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031642", "evidence": [ { "database": "UniProtKB", "id": "A6KTC8", "url": "https://www.uniprot.org/uniprot/A6KTC8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "intracellular membrane-bounded organelle", "id": "GO:0043231", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043231", "evidence": [ { "database": "UniProtKB", "id": "A6KTC8", "url": "https://www.uniprot.org/uniprot/A6KTC8" } ], "pmid": "" }, { "name": "endosome membrane", "id": "GO:0010008", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010008", "evidence": [ { "database": "UniProtKB", "id": "A6KTC8", "url": "https://www.uniprot.org/uniprot/A6KTC8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 137, "end_pos": 139, "annotation": "n_glycosylation_sequon" }, { "start_pos": 178, "end_pos": 180, "annotation": "n_glycosylation_sequon" }, { "start_pos": 728, "end_pos": 730, "annotation": "n_glycosylation_sequon" }, { "start_pos": 74, "end_pos": 76, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "sequence_features": { 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