{ "uniprot_canonical_ac": "A6KAR2-1", "uniprot_ac": "A6KAR2", "uniprot_id": "A6KAR2_RAT", "mass": { "chemical_mass": 69799.0, "monoisotopic_mass": 69799.0 }, "refseq": { "ac": "NP_001101516", "name": "probable ATP-dependent RNA helicase DDX41", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101516" }, "gene_names": [ { "name": "Ddx41l1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A6KAR2", "id": "A6KAR2" }, { "name": "Ddx41", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A6KAR2", "id": "A6KAR2" }, { "name": "Ddx41l1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A6KAR2", "id": "A6KAR2" }, { "name": "Ddx41", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101516", "id": "NP_001101516" }, { "name": "LOC120103587", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A6KAR2", "id": "A6KAR2" } ], "protein_names": [ { "name": "RNA helicase", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprotkb/A6KAR2/entry#names_and_taxonomy", "id": "A6KAR2" }, { "name": "3.6.4.13", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A6KAR2/entry#names_and_taxonomy", "id": "A6KAR2" }, { "name": "DEAD (Asp-Glu-Ala-Asp) box polypeptide 41; probable ATP-dependent RNA helicase DDX41-like", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101516", "id": "NP_001101516" }, { "name": "probable ATP-dependent RNA helicase DDX41", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101516", "id": "NP_001101516" } ], "function": [ { "annotation": "DDX41 is involved in the dsDNA- and dsDNA-virus-mediated type IFN-beta signaling pathway in porcine kidney cells. [DDX41]", "evidence": [ { "database": "RefSeq", "id": "NP_001101516", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101516" }, { "database": "PubMed", "id": "25086295", "url": "https://glygen.org/publication/PubMed/25086295" } ] } ], "disease": [ { "disease_id": "DOID:2226", "recommended_name": { "id": "DOID:2226", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2226", "name": "myeloproliferative neoplasm", "description": "A myeloid neoplasm that is characterized by a group of slow growing blood cancers in which large numbers of abnormal red blood cells, white blood cells, or platelets grow and spread in the bone marrow and the peripheral blood." }, "synonyms": [ { "id": "DOID:2226", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2226", "name": "CMPD", "description": "" }, { "id": "DOID:2226", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2226", "name": "CMPD, U", "description": "" }, { "id": "DOID:2226", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2226", "name": "chronic myeloproliferative disease", "description": "" } ], "evidence": [ { "id": "2226", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:2226" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "A6KAR2", "url": "https://www.uniprot.org/uniprot/A6KAR2" } ], "common_name": "Rat", "glygen_name": "Rat", "reference_species": "Rattus norvegicus [10116]" } ], "gene": [ { "name": "Ddx41", "url": "https://www.uniprot.org/uniprot/A6KAR2", "locus": { "chromosome": "17", "start_pos": 9108415, "end_pos": 9103010, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000012771", "url": "https://www.ensembl.org/id/ENSRNOG00000012771" } ] } } ], "crossref": [ { "id": "ENSRNOG00000012771", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000012771", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd17951", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd17951", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd18787", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18787", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "314336", "url": "https://www.ncbi.nlm.nih.gov/gene/314336", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "A6KAR2", "url": "https://www.ebi.ac.uk/intact/interactors/id:A6KAR2*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR001650", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001650", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011545", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011545", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014001", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014001", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014014", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014014", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR044113", "url": "https://www.ebi.ac.uk/interpro/entry/IPR044113", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "rno:314336", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:314336", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "LGDERGC", "url": "https://omabrowser.org/oma/group/LGDERGC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "MESGYPE", "url": "https://omabrowser.org/oma/group/MESGYPE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "5487240at2759", "url": "http://www.orthodb.org/?query=5487240at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR47958", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47958", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR47958:SF103", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47958:SF103", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00270", "url": "http://pfam.xfam.org/family/PF00270", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF00271", "url": "http://pfam.xfam.org/family/PF00271", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "NP_001101516", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101516", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "1311758", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1311758", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "40990865", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=40990865", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "13065", "url": "https://www.rhea-db.org/rhea/13065", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A8I5ZL40", "url": "https://www.uniprot.org/uniprot/A0A8I5ZL40", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I5ZL40-1", "url": "https://www.uniprot.org/uniprot/A0A8I5ZL40-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6AB28", "url": "https://www.uniprot.org/uniprot/A0A8I6AB28", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6AB28-1", "url": "https://www.uniprot.org/uniprot/A0A8I6AB28-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6GGV4", "url": "https://www.uniprot.org/uniprot/A0A8I6GGV4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6GGV4-1", "url": "https://www.uniprot.org/uniprot/A0A8I6GGV4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A6KAR2", "url": "https://www.uniprot.org/uniprot/A6KAR2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A6KAR2-1", "url": "https://www.uniprot.org/uniprot/A6KAR2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEESEPERKRARTNEATAGGSRSEDEDEDDEDYVPYVPLRQRRQLLLQKLLQRRRKGAAEEEQQDSGSEPRGDEDDIPLGPQSNVSLLDQHQHLKEKAEARKESAKEKQLKEEEKILESVAEGRALMSVKEMAKGITYDDPIKTSWTPPRYVLSMSEERHERVRKKYHILVEGDGIPPPIKSFKEMKLPAAILRGLKKKGILHPTPIQIQGIPTILSGRDMIGIAFTGSGKTLVFTLPVIMFCLEQEKRLPFSKREGPYGLIICPSRELARQTHGILEYYCRLLQEDSSPLLRCALCIGGMSVKEQMETIRHGVHMMVATPGRLMDLLQKKMVSLDICRYLALDEADRMIDMGFEGDIRTIFSYFKGQRQTLLFSATMPKKIQNFAKSALVKPVTINVGRAGAASLDVIQEVEYVKEEAKMVYLLECLQKTPPPVLIFAEKKADVDAIHEYLLLKGVEAVAIHGGKDQEERTKAIEAFREGKKDVLVATDVASKGLDFPAIQHVINYDMPEEIENYVHRIGRTGRSGNTGIATTFINKACDESVLMDLKALLLEAKQKVPPVLQVLHCGDESMLDIGGERGCAFCGGLGHRITDCPKLEAMQTKQVSNIGRKDYLAHSSMDF", "length": 622, "header": "tr|A6KAR2-1|A6KAR2_RAT Isoform 1 of RNA helicase OS=Rattus norvegicus OX=10116 GN=Ddx41 PE=1 SV=1 CANONICAL=A6KAR2-1" }, "isoforms": [ { "isoform_ac": "A0A8I5ZL40-1", "url": "https://www.uniprot.org/uniprotkb/A6KAR2/entry#A0A8I5ZL40-1", "sequence": { "sequence": "MEEWEPERKRARRNQATAGASHSEDEDEDYVPYVPLRQRRQLLLQKLLQQRRKGAAEEEQQDSGSGSEPRGDEDNITLGPQSNVSLLDQHQRLKEKAEARKESAKEKQLKEEEKILESVAEGRALMSVKEMAKGITYDDPIKTSWTPPRYVLSMSEERHERVRKKYHILVEGDGIPPPIKSFKEMKLPAAILRGLKKKGILHPTPIQIQGIPTILSGRDMIGIAFTGSGKTLVFTLPVIMFCLEQEKRLPFSKREGPYGLIICPSRELARQTHGILEYYCRLLQEDSSPLLHCALCIGGVSLKEQMETMRHGVHIMVATPGRLMDLLQKKMVSLDICRYLALDEADRMIDMGFEGDIRTIFSYFKGQRQTLLFSATMPKKIQNFAKSALVKPVTINVGRAGAASLDVIQEVEYVKEEAKMVYLLECLQKTPPPVLIFAKKKADVDAIHEYLLLKGVEAVAIHGGKDQEERTKAIEAFREGKKDVLVATDVASKGLDFPAIQHVINYDMPEEIENYVHRIGRTGRSGNTGIATTFINKACDESVLMDLKALLLEAKQKVPPVLQVLHCGDESMLDIGGEQGCAFCGGLGHRITDCPKLEAMQTKQVSNIGHKDYLAHSSMDF", "length": 621, "header": "tr|A0A8I5ZL40-1|A6KAR2_RAT Computationally mapped isoform of RNA helicase OS=Rattus norvegicus OX=10116 GN=Ddx41 PE=1 SV=1 CANONICAL=A6KAR2-1" }, "locus": { "chromosome": "6", "start_pos": 107187961, "end_pos": 107186099, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000072451.3", "url": "https://www.ensembl.org/id/ENSRNOT00000072451.3" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000078554.1", "url": "https://www.ensembl.org/id/ENSRNOP00000078554.1" } ] } }, { "isoform_ac": "A0A8I6AB28-1", "url": "https://www.uniprot.org/uniprotkb/A6KAR2/entry#A0A8I6AB28-1", "sequence": { "sequence": "MEESEPERKRARTNEATAGGSRSEDEDEDDEDYVPYVPLRQRRQLLLQKLLQRRRKGAAEEEQQDSGSEPRGDEDDIPLGPQSNVSLLDQHQHLKEKAEARKESAKEKQLKEEEKILESVAEGRGTIIVGADRLCPKGWTPPRYVLSMSEERHERVRKKYHILVEGDGIPPPIKSFKEMKLPAAILRGLKKKGILHPTPIQIQGIPTILSGRDMIGIAFTGSGKTLVFTLPVIMFCLEQEKRLPFSKREGPYGLIICPSRELARQTHGILEYYCRLLQEDSSPLLRCALCIGGMSVKEQMETIRHGVHMMVATPGRLMDLLQKKMVSLDICRYLALDEADRMIDMGFEGDIRTIFSYFKGQRQTLLFSATMPKKIQNFAKSALVKPVTINVGRAGAASLDVIQEVEYVKEEAKMVYLLECLQKTPPPVLIFAEKKADVDAIHEYLLLKGVEAVAIHGGKDQEERTKAIEAFREGKKDVLVATDVASKGLDFPAIQHVINYDMPEEIENYVHRIGRTGRSGNTGIATTFINKACDESVLMDLKALLLEAKQKVPPVLQVLHCGDESMLDIGGERGCAFCGGLGHRITDCPKLEAMQTKQVSNIGRKDYLAHSSMDF", "length": 615, "header": "tr|A0A8I6AB28-1|A6KAR2_RAT Computationally mapped isoform of RNA helicase OS=Rattus norvegicus OX=10116 GN=Ddx41 PE=1 SV=1 CANONICAL=A6KAR2-1" }, "locus": { "chromosome": "17", "start_pos": 9108236, "end_pos": 9103028, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000118011.1", "url": "https://www.ensembl.org/id/ENSRNOT00000118011.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000090065.1", "url": "https://www.ensembl.org/id/ENSRNOP00000090065.1" } ] } }, { "isoform_ac": "A0A8I6GGV4-1", "url": "https://www.uniprot.org/uniprotkb/A6KAR2/entry#A0A8I6GGV4-1", "sequence": { "sequence": "MEESEPERKVGLRLGPREGLRLQKLLQRRRKGAAEEEQQDSGSEPRGDEDDIPLGPQSNVSLLDQHQHLKEKAEARKESAKEKQLKEEEKILESVAEGRALMSVKEMAKGITYDDPIKTSWTPPRYVLSMSEERHERVRKKYHILVEGDGIPPPIKSFKEMKLPAAILRGLKKKGILHPTPIQIQGIPTILSGRDMIGIAFTGSGKTLVFTLPVIMFCLEQEKRLPFSKREGPYGLIICPSRELARQTHGILEYYCRLLQEDSSPLLRCALCIGGMSVKEQMETIRHGVHMMVATPGRLMDLLQKKMVSLDICRYLALDEADRMIDMGFEGDIRTIFSYFKGQRQTLLFSATMPKKIQNFAKSALVKPVTINVGRAGAASLDVIQEVEYVKEEAKMVYLLECLQKTPPPVLIFAEKKADVDAIHEYLLLKGVEAVAIHGGKDQEERTKAIEAFREGKKDVLVATDVASKGLDFPAIQHVINYDMPEEIENYVHRIGRTGRSGNTGIATTFINKACDESVLMDLKALLLEAKQKVPPVLQVLHCGDESMLDIGGERGCAFCGGLGHRITDCPKLEAMQTKQVSNIGRKDYLAHSSMDF", "length": 597, "header": "tr|A0A8I6GGV4-1|A6KAR2_RAT Computationally mapped isoform of RNA helicase OS=Rattus norvegicus OX=10116 GN=Ddx41 PE=1 SV=1 CANONICAL=A6KAR2-1" }, "locus": { "chromosome": "17", "start_pos": 9108236, "end_pos": 9103028, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000097585.1", "url": "https://www.ensembl.org/id/ENSRNOT00000097585.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000088216.1", "url": "https://www.ensembl.org/id/ENSRNOP00000088216.1" } ] } }, { "isoform_ac": "A6KAR2-1", "url": "https://www.uniprot.org/uniprotkb/A6KAR2/entry#A6KAR2-1", "sequence": { "sequence": "MEESEPERKRARTNEATAGGSRSEDEDEDDEDYVPYVPLRQRRQLLLQKLLQRRRKGAAEEEQQDSGSEPRGDEDDIPLGPQSNVSLLDQHQHLKEKAEARKESAKEKQLKEEEKILESVAEGRALMSVKEMAKGITYDDPIKTSWTPPRYVLSMSEERHERVRKKYHILVEGDGIPPPIKSFKEMKLPAAILRGLKKKGILHPTPIQIQGIPTILSGRDMIGIAFTGSGKTLVFTLPVIMFCLEQEKRLPFSKREGPYGLIICPSRELARQTHGILEYYCRLLQEDSSPLLRCALCIGGMSVKEQMETIRHGVHMMVATPGRLMDLLQKKMVSLDICRYLALDEADRMIDMGFEGDIRTIFSYFKGQRQTLLFSATMPKKIQNFAKSALVKPVTINVGRAGAASLDVIQEVEYVKEEAKMVYLLECLQKTPPPVLIFAEKKADVDAIHEYLLLKGVEAVAIHGGKDQEERTKAIEAFREGKKDVLVATDVASKGLDFPAIQHVINYDMPEEIENYVHRIGRTGRSGNTGIATTFINKACDESVLMDLKALLLEAKQKVPPVLQVLHCGDESMLDIGGERGCAFCGGLGHRITDCPKLEAMQTKQVSNIGRKDYLAHSSMDF", "length": 622, "header": "tr|A6KAR2-1|A6KAR2_RAT Isoform 1 of RNA helicase OS=Rattus norvegicus OX=10116 GN=Ddx41 PE=1 SV=1 CANONICAL=A6KAR2-1" }, "locus": { "chromosome": "17", "start_pos": 9108236, "end_pos": 9103028, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000018114.6", "url": "https://www.ensembl.org/id/ENSRNOT00000018114.6" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000018114.5", "url": "https://www.ensembl.org/id/ENSRNOP00000018114.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.", "journal": "Nat. Commun.", "date": "2012", "authors": "Lundby A, Secher A, Lage K, Nordsborg NB, Dmytriyev A, Lundby C, Olsen JV", "evidence": [ { "database": "UniProtKB", "id": "A6KAR2", "url": "https://www.uniprot.org/uniprot/A6KAR2" } ], "reference": [ { "type": "PubMed", "id": "22673903", "url": "https://glygen.org/publication/PubMed/22673903" } ] }, { "title": "Molecular cloning and functional characterization of porcine DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 (DDX41).", "journal": "Developmental and comparative immunology", "date": "2014", "authors": "Zhu X, Wang D, Zhang H, Zhou Y, Luo R, Chen H, Xiao S, Fang L", "evidence": [ { "database": "RefSeq", "id": "NP_001101516", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101516" } ], "reference": [ { "type": "PubMed", "id": "25086295", "url": "https://glygen.org/publication/PubMed/25086295" } ] } ], "pathway": [ { "id": "rno:314336", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:314336", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "K9IVT8-1", "protein_name": "RNA helicase", "gene_name": "DDX41", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MEESEPERKRARTDEATATGSRSEAEDEDDEDYVPYVPLRQRRQLLLQKLLQRRRKGAAEEEQQDSGSEPRGDEDDIPLGPQSNVSLLDQHQHLKEKAEARKESAKEKQLKEEEKILESVAEGRALMSVKEMAKGITYDDPIKTSWTPPRYVLSMSEERHERVRKKYHILVEGDGIPPPIKSFKEMKFPAAILRGLKKKGIHHPTPIQIQGIPTILSGRDMIGIAFTGSGKTLVFTLPVIMFCLEQEKRLPFSKREGPYGLIICPSRELARQTHGILEYYCRLLQEDSSPLLRCALCIGGMSVKEQMETIRHGVHMMVATPGRLMDLLQKKMVSLDICRYLALDEADRMIDMGFEGDIRTIFSYFKGQRQTLLFSATMPKKIQNFAKSALVKPVTINVGRAGAASLDVIQEVEYVKEEAKMVYLLECLQKTPPPVLIFAEKKADVDAIHEYLLLKGVEAVAIHGGKDQEERTKAIEAFREGKKDVLVATDVASKGLDFPAIQHVINYDMPEEIENYVHRIGRTGRSGNTGIATTFINKACDESVLMDLKALLLEAKQKVPPVLQVLHCGDESMLDIGGERGCAFCGGLGHRITDCPKLEAMQTKQVSNIGRKDYLAHSSMDF", "length": 622 }, "evidence": [ { "id": "A6KAR2", "url": "https://omabrowser.org/oma/group/A6KAR2/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q54KG1-1", "protein_name": "Probable ATP-dependent RNA helicase ddx41", "gene_name": "ddx41", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MSEESRKHDIEEQHIEKWIPLKERKLNQIKSKLNNLKQQQPQQHSQQQENEQNNATATNTNITNTTTTTTTTTTTTTSSNNDNNFEDEKKPIYQQSQSLLDQKFEMIKKQENKTQRELQQGGTIIENDVNSSNNNNNNGEENKIKEEKRLDMEESDILKSLKTFKPLVSVKDRAKDVIYTDSIKTNWRAPRYILERDEKDHQKVRDQLNIITDGEDIPPPITTFKEMKIPKPVIDVLLEKGIKKPSPIQVQGLPVILSGRDMIGIAYTGSGKTLVFTLPMVLFALEEECKLPIIQGEGPFGLILCPSRELARQTYDLVNSFTNALHKNGGHPQLRTLLAIGGIDLREQEHIFKKGVHMIIATPGRLLDLLNKKKINFKLCKYLGLDEADRLIDLGFEDDIRSVLDNFTNQRQTLLFSATMPKKIQEFARSALVLPVEVNVGRAGAANLNVTQEVEFVKPEAKIVYLLECLQKTPPPVLIFCENKKDVDDIYEYLLLKQVEAVSIHGDKSQDERESAIKAFREGKKDVLVATDVASKGLDFPEIQHVINFDMPREIENYIHRIGRTGRRGNKGVATTFINKNNTESLLLDLKYLLIEAKQKVPPALLEIPDDNQYLQKLQDRNGNTGGGADDDDTKPCEYCDGRGHRLVNCPKLKKQAGPKRDFFGSGGGDW", "length": 671 }, "evidence": [ { "id": "A6KAR2", "url": "https://omabrowser.org/oma/group/A6KAR2/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q91VN6-1", "protein_name": "Probable ATP-dependent RNA helicase DDX41", "gene_name": "Ddx41", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEDSEPERKRARADEATAGGSRSEDEDEDDEDYVPYVPLRQRRQLLLQKLLQRRRKGATEEEQQDSGSEPRGDEDDIPLGPQSNVSLLDQHQHLKEKAEARKESAKEKQLKEEEKILESVAEGRALMSVKEMAKGITYDDPIKTSWTPPRYVLSMSEERHERVRKKYHILVEGDGIPPPIKSFKEMKFPAAILRGLKKKGILHPTPIQIQGIPTILSGRDMIGIAFTGSGKTLVFTLPVIMFCLEQEKRLPFSKREGPYGLIICPSRELARQTHGILEYYCRLLQEDSSPLLRCALCIGGMSVKEQMETIRHGVHMMVATPGRLMDLLQKKMVSLDICRYLALDEADRMIDMGFEGDIRTIFSYFKGQRQTLLFSATMPKKIQNFAKSALVKPVTINVGRAGAASLDVIQEVEYVKEEAKMVYLLECLQKTPPPVLIFAEKKADVDAIHEYLLLKGVEAVAIHGGKDQEERTKAIEAFREGKKDVLVATDVASKGLDFPAIQHVINYDMPEEIENYVHRIGRTGRSGNTGIATTFINKACDESVLMDLKALLLEAKQKVPPVLQVLHCGDESMLDIGGERGCAFCGGLGHRITDCPKLEAMQTKQVSNIGRKDYLAHSSMDF", "length": 622 }, "evidence": [ { "id": "46358701", "url": "http://www.informatics.jax.org/homology/46358701", "database": "MGI" }, { "id": "A6KAR2", "url": "https://omabrowser.org/oma/group/A6KAR2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9UJV9-1", "protein_name": "Probable ATP-dependent RNA helicase DDX41", "gene_name": "DDX41", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEESEPERKRARTDEVPAGGSRSEAEDEDDEDYVPYVPLRQRRQLLLQKLLQRRRKGAAEEEQQDSGSEPRGDEDDIPLGPQSNVSLLDQHQHLKEKAEARKESAKEKQLKEEEKILESVAEGRALMSVKEMAKGITYDDPIKTSWTPPRYVLSMSEERHERVRKKYHILVEGDGIPPPIKSFKEMKFPAAILRGLKKKGIHHPTPIQIQGIPTILSGRDMIGIAFTGSGKTLVFTLPVIMFCLEQEKRLPFSKREGPYGLIICPSRELARQTHGILEYYCRLLQEDSSPLLRCALCIGGMSVKEQMETIRHGVHMMVATPGRLMDLLQKKMVSLDICRYLALDEADRMIDMGFEGDIRTIFSYFKGQRQTLLFSATMPKKIQNFAKSALVKPVTINVGRAGAASLDVIQEVEYVKEEAKMVYLLECLQKTPPPVLIFAEKKADVDAIHEYLLLKGVEAVAIHGGKDQEERTKAIEAFREGKKDVLVATDVASKGLDFPAIQHVINYDMPEEIENYVHRIGRTGRSGNTGIATTFINKACDESVLMDLKALLLEAKQKVPPVLQVLHCGDESMLDIGGERGCAFCGGLGHRITDCPKLEAMQTKQVSNIGRKDYLAHSSMDF", "length": 622 }, "evidence": [ { "id": "46358701", "url": "http://www.informatics.jax.org/homology/46358701", "database": "MGI" }, { "id": "A6KAR2", "url": "https://omabrowser.org/oma/group/A6KAR2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9V3C0-1", "protein_name": "ATP-dependent RNA helicase abstrakt", "gene_name": "abs", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MAHVKRYRRSSKSSEEGDLDNEDYVPYVPVKERKKQHMIKLGRIVQLVSETAQPKSSSENENEDDSQGAHDVETWGRKYNISLLDQHTELKKIAEAKKLSAVEKQLREEEKIMESIAQQKALMGVAELAKGIQYEQPIKTAWKPPRYIREMSEEEREAVRHELRILVEGETPSPPIRSFREMKFPKGILNGLAAKGIKNPTPIQVQGLPTVLAGRDLIGIAFTGSGKTLVFVLPVIMFALEQEYSLPFERNEGPYGLIICPSRELAKQTHEIIQHYSKHLQACGMPEIRSCLAMGGLPVSEALDVISRGVHIVVATPGRLMDMLDKKILTLDMCRYLCMDEADRMIDMGFEEDVRTIFSFFKGQRQTLLFSATMPKKIQNFARSALVKPVTINVGRAGAASMNVTQQVEYVKQEAKVVYLLDCLQKTAPPVLIFAEKKQDVDCIHEYLLLKGVEAVAIHGGKDQEERSRAVDAYRVGKKDVLVATDVASKGLDFPNVQHVINYDMPDDIENYVHRIGRTGRSNTKGLATTLINKTTEQSVLLDLKHLLIEGKQEVPDFLDELAPETEHQHLDLGDSHGCTYCGGLGHRITECPKLEAVQNKQASNIGRRDYLSNTAADY", "length": 619 }, "evidence": [ { "id": "A6KAR2", "url": "https://omabrowser.org/oma/group/A6KAR2/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 6, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A6KAR2", "url": "https://www.uniprot.org/uniprot/A6KAR2" } ], "pmid": "" }, { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "A6KAR2", "url": "https://www.uniprot.org/uniprot/A6KAR2" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A6KAR2", "url": "https://www.uniprot.org/uniprot/A6KAR2" } ], "pmid": "" }, { "name": "hydrolase activity", "id": "GO:0016787", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016787", "evidence": [ { "database": "UniProtKB", "id": "A6KAR2", "url": "https://www.uniprot.org/uniprot/A6KAR2" } ], "pmid": "" }, { "name": "RNA helicase activity", "id": "GO:0003724", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003724", "evidence": [ { "database": "UniProtKB", "id": "A6KAR2", "url": "https://www.uniprot.org/uniprot/A6KAR2" } ], "pmid": "" }, { "name": "nucleic acid binding", "id": "GO:0003676", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003676", "evidence": [ { "database": "UniProtKB", "id": "A6KAR2", "url": "https://www.uniprot.org/uniprot/A6KAR2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A6KAR2", "url": "https://www.uniprot.org/uniprot/A6KAR2" } ], "pmid": "" }, { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "A6KAR2", "url": "https://www.uniprot.org/uniprot/A6KAR2" } ], "pmid": "" }, { "name": "spliceosomal complex", "id": "GO:0005681", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005681", "evidence": [ { "database": "UniProtKB", "id": "A6KAR2", "url": "https://www.uniprot.org/uniprot/A6KAR2" } ], "pmid": "" }, { "name": "catalytic step 2 spliceosome", "id": "GO:0071013", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071013", "evidence": [ { "database": "UniProtKB", "id": "A6KAR2", "url": "https://www.uniprot.org/uniprot/A6KAR2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "cell population proliferation", "id": "GO:0008283", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008283", "evidence": [ { "database": "UniProtKB", "id": "A6KAR2", "url": "https://www.uniprot.org/uniprot/A6KAR2" } ], "pmid": "" }, { "name": "cell differentiation", "id": "GO:0030154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "database": "UniProtKB", "id": "A6KAR2", "url": "https://www.uniprot.org/uniprot/A6KAR2" } ], "pmid": "" }, { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "A6KAR2", "url": "https://www.uniprot.org/uniprot/A6KAR2" } ], "pmid": "" }, { "name": "defense response to virus", "id": "GO:0051607", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051607", "evidence": [ { "database": "UniProtKB", "id": "A6KAR2", "url": "https://www.uniprot.org/uniprot/A6KAR2" } ], "pmid": "" }, { "name": "cellular response to interferon-beta", "id": "GO:0035458", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035458", "evidence": [ { "database": "UniProtKB", "id": "A6KAR2", "url": "https://www.uniprot.org/uniprot/A6KAR2" } ], "pmid": "" }, { "name": "mRNA splicing, via spliceosome", "id": "GO:0000398", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000398", "evidence": [ { "database": "UniProtKB", "id": "A6KAR2", "url": "https://www.uniprot.org/uniprot/A6KAR2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 84, "end_pos": 86, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "13065", "name": "", "equation": "ATP + H2O = ADP + H(+) + phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "D3ZD32-1", "D4A523-1", "Q3MHU3-1", "F1M298-1", "Q5RJZ1-1", "P60123-1", "Q793F9-1", "F1LPQ2-1", "G3V681-1", "F1LNJ2-1", "D4A2Z8-1", "Q5RKI1-1", "P70486-1", "Q66HG7-1", "Q99PT0-1", "D3ZG52-1", "Q4G005-1", "Q5U216-1", "Q62780-1", "Q641Y8-1", "Q5BJS0-1", "Q63413-1", "Q64060-1", "Q9JIX5-1", "P06761-1", "Q6GX84-1", "Q5XI69-1", "Q9QUL6-1", "Q1HG60-1", "Q3B8Q2-1", "P46462-1", "D3ZA12-1", "D3Z9Z9-1", "Q68G38-1", "Q9QY16-1", "A0A8I5ZZZ0-1", "A0A0G2K0H9-1", "Q6AYJ1-1", "Q62724-1", "Q5EBA1-1", "Q3B8Q1-1", "Q9EQN5-1", "F1M9L4-1", "F1M5F3-1", "D3ZFP4-1", "F1MA70-1", "D3ZBY5-1", "D3ZX56-1", "D3ZVK1-1", "B1H269-1", "Q9WTT2-1", "G3V8T5-1", "Q8CG07-1", "B2GUX3-1", "P08289-1", "D3ZP96-1", "D3ZHW0-1", "Q5XIR6-1", "A0A8I6AFW4-1", "Q5XI46-1", "A0A0G2KA92-1", "D4AAG9-1", "A0A096MJV7-1", "A0A0G2JTM6-1", "A0A8I5ZKV9-1", "A0A8I5ZKH1-1", "D3ZD46-1", "A0A8I6GIY0-1", "E9PU01-1", "A0A8I6ABZ7-1", "D3ZAP7-1", "D3ZQW1-1", "D4A321-1", "A0A0G2K283-1", "Q6MG13-1", "P62738-1", "P63259-1", "P68035-1", "P68136-1", "P60711-1", "P63269-1", "P56536-1", "P54777-1", "D3ZSV6-1", "D3ZUC2-1", "G3V6W5-1", "D3ZD97-1", "F1LTH9-1", "D3ZEG9-1", "A6KAR2-1", "P63018-1", "P82995-1", "D4ADT5-1", "D4A6Q6-1", "A0A8I5ZMZ5-1", "D4ACP5-1", "A0A8I6GIN4-1", "A6KSS8-1", "D4A2B7-1", "A0A0G2K4S4-1", "A0A8I6AK63-1", "F1LTR3-1", "F1LWY1-1", "D4A1R0-1", "P97687-1", "Q641Z7-1", "Q5EB68-1", "D4A628-1" ], "evidence": [ { "id": "13065", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/13065" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A096MJV7", "gene_name": "Chd9", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "A0A096MJV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A096MJV7" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0A096MJV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A096MJV7" } ] } ] }, { "uniprot_ac": "A0A0G2JTM6", "gene_name": "Dhx35", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "A0A0G2JTM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2JTM6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A0G2JTM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2JTM6" } ] } ] }, { "uniprot_ac": "A0A0G2K0H9", "gene_name": "Ruvbl1-ps1", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "A0A0G2K0H9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K0H9" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0A0G2K0H9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K0H9" } ] } ] }, { "uniprot_ac": "A0A0G2K283", "gene_name": "Dhx8", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "A0A0G2K283", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K283" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A0G2K283", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K283" } ] } ] }, { "uniprot_ac": "A0A0G2K4S4", "gene_name": "Ddx51", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "A0A0G2K4S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K4S4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A0G2K4S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K4S4" } ] } ] }, { "uniprot_ac": "A0A0G2KA92", "gene_name": "Chd2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "A0A0G2KA92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2KA92" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0A0G2KA92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2KA92" } ] } ] }, { "uniprot_ac": "A0A8I5ZKH1", "gene_name": "Ythdc2", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "A0A8I5ZKH1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZKH1" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A8I5ZKH1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZKH1" } ] } ] }, { "uniprot_ac": "A0A8I5ZKV9", "gene_name": "Ddx5", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "A0A8I5ZKV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZKV9" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A8I5ZKV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZKV9" } ] } ] }, { "uniprot_ac": "A0A8I5ZMZ5", "gene_name": "LOC100912568", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "A0A8I5ZMZ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZMZ5" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A8I5ZMZ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZMZ5" } ] } ] }, { "uniprot_ac": "A0A8I5ZZZ0", "gene_name": "Ddx31", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "A0A8I5ZZZ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZZZ0" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A8I5ZZZ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZZZ0" } ] } ] }, { "uniprot_ac": "A0A8I6ABZ7", "gene_name": "Dhx9", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "A0A8I6ABZ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6ABZ7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A8I6ABZ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6ABZ7" } ] } ] }, { "uniprot_ac": "A0A8I6AFW4", "gene_name": "Ddx24", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "A0A8I6AFW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6AFW4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A8I6AFW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6AFW4" } ] } ] }, { "uniprot_ac": "A0A8I6AK63", "gene_name": "ENSRNOG00000069014", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "A0A8I6AK63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6AK63" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0A8I6AK63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6AK63" } ] } ] }, { "uniprot_ac": "A0A8I6GIN4", "gene_name": "AC129365.1", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "A0A8I6GIN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6GIN4" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0A8I6GIN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6GIN4" } ] } ] }, { "uniprot_ac": "A0A8I6GIY0", "gene_name": "Chd3", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "A0A8I6GIY0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6GIY0" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0A8I6GIY0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6GIY0" } ] } ] }, { "uniprot_ac": "A6KAR2", "gene_name": "Ddx41", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "A6KAR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A6KAR2" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A6KAR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A6KAR2" } ] } ] }, { "uniprot_ac": "A6KSS8", "gene_name": "Mcm7", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "A6KSS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A6KSS8" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A6KSS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A6KSS8" } ] } ] }, { "uniprot_ac": "B1H269", "gene_name": "Ddx27", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "B1H269", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B1H269" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "B1H269", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B1H269" } ] } ] }, { "uniprot_ac": "B2GUX3", "gene_name": "Mcm5", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "B2GUX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B2GUX3" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "B2GUX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B2GUX3" } ] } ] }, { "uniprot_ac": "D3Z9Z9", "gene_name": "Smarcad1", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D3Z9Z9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3Z9Z9" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "D3Z9Z9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3Z9Z9" } ] } ] }, { "uniprot_ac": "D3ZA12", "gene_name": "Chd6", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D3ZA12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZA12" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "D3ZA12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZA12" } ] } ] }, { "uniprot_ac": "D3ZAP7", "gene_name": "Chd7", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D3ZAP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZAP7" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "D3ZAP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZAP7" } ] } ] }, { "uniprot_ac": "D3ZBY5", "gene_name": "Ddx10", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D3ZBY5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZBY5" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "D3ZBY5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZBY5" } ] } ] }, { "uniprot_ac": "D3ZD32", "gene_name": "Chd5", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D3ZD32", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZD32" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "D3ZD32", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZD32" } ] } ] }, { "uniprot_ac": "D3ZD46", "gene_name": "Dhx58", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D3ZD46", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZD46" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "D3ZD46", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZD46" } ] } ] }, { "uniprot_ac": "D3ZD97", "gene_name": "Dhx15", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D3ZD97", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZD97" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "D3ZD97", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZD97" } ] } ] }, { "uniprot_ac": "D3ZEG9", "gene_name": "Ercc2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D3ZEG9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZEG9" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "D3ZEG9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZEG9" } ] } ] }, { "uniprot_ac": "D3ZFP4", "gene_name": "Mcm3", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D3ZFP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZFP4" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "D3ZFP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZFP4" } ] } ] }, { "uniprot_ac": "D3ZG52", "gene_name": "Dna2", "activity": [ { "ec_number": "3.1.-.-", "activity": "", "evidence": [ { "id": "D3ZG52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZG52" } ] }, { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D3ZG52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZG52" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "D3ZG52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZG52" } ] } ] }, { "uniprot_ac": "D3ZHW0", "gene_name": "Dhx29", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D3ZHW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZHW0" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "D3ZHW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZHW0" } ] } ] }, { "uniprot_ac": "D3ZP96", "gene_name": "Mcm2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D3ZP96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZP96" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "D3ZP96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZP96" } ] } ] }, { "uniprot_ac": "D3ZQW1", "gene_name": "Blm", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D3ZQW1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZQW1" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "D3ZQW1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZQW1" } ] } ] }, { "uniprot_ac": "D3ZSV6", "gene_name": "Dhx33", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D3ZSV6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZSV6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "D3ZSV6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZSV6" } ] } ] }, { "uniprot_ac": "D3ZUC2", "gene_name": "Mov10", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D3ZUC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZUC2" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "D3ZUC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZUC2" } ] } ] }, { "uniprot_ac": "D3ZVK1", "gene_name": "Mcm8", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D3ZVK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZVK1" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "D3ZVK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZVK1" } ] } ] }, { "uniprot_ac": "D3ZX56", "gene_name": "Ddx55", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D3ZX56", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZX56" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "D3ZX56", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZX56" } ] } ] }, { "uniprot_ac": "D4A1R0", "gene_name": "Dhx37", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D4A1R0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A1R0" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "D4A1R0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A1R0" } ] } ] }, { "uniprot_ac": "D4A2B7", "gene_name": "Afg2b", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D4A2B7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A2B7" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "D4A2B7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A2B7" } ] } ] }, { "uniprot_ac": "D4A2Z8", "gene_name": "Dhx36", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D4A2Z8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A2Z8" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D4A2Z8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A2Z8" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "D4A2Z8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A2Z8" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "D4A2Z8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A2Z8" } ] } ] }, { "uniprot_ac": "D4A321", "gene_name": "Dhx38", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D4A321", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A321" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "D4A321", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A321" } ] } ] }, { "uniprot_ac": "D4A523", "gene_name": "Nlrp3", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "D4A523", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A523" } ] } ] }, { "uniprot_ac": "D4A628", "gene_name": "Polq", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D4A628", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A628" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "D4A628", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A628" } ] } ] }, { "uniprot_ac": "D4A6Q6", "gene_name": "Ino80", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "D4A6Q6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A6Q6" } ] } ] }, { "uniprot_ac": "D4AAG9", "gene_name": "Chd1", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D4AAG9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4AAG9" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "D4AAG9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4AAG9" } ] } ] }, { "uniprot_ac": "D4ACP5", "gene_name": "Recql5", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D4ACP5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4ACP5" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "D4ACP5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4ACP5" } ] }, { "ec_number": "5.6.2.4", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.", "evidence": [ { "id": "D4ACP5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4ACP5" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "D4ACP5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4ACP5" } ] } ] }, { "uniprot_ac": "D4ADT5", "gene_name": "Rig1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D4ADT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4ADT5" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "D4ADT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4ADT5" } ] } ] }, { "uniprot_ac": "E9PU01", "gene_name": "Chd4", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "E9PU01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9PU01" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "E9PU01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9PU01" } ] } ] }, { "uniprot_ac": "F1LNJ2", "gene_name": "Snrnp200", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "F1LNJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LNJ2" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1LNJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LNJ2" } ] } ] }, { "uniprot_ac": "F1LPQ2", "gene_name": "Ascc3", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "F1LPQ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LPQ2" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "F1LPQ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LPQ2" } ] } ] }, { "uniprot_ac": "F1LTH9", "gene_name": "Wrn", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "F1LTH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LTH9" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "F1LTH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LTH9" } ] } ] }, { "uniprot_ac": "F1LTR3", "gene_name": "Tdrd12", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "F1LTR3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LTR3" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1LTR3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LTR3" } ] } ] }, { "uniprot_ac": "F1LWY1", "gene_name": "Hfm1", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "F1LWY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LWY1" } ] }, { "ec_number": "3.6.4.12", "activity": "", 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"activity": "", "evidence": [ { "id": "P70486", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P70486" } ] } ] }, { "uniprot_ac": "P82995", "gene_name": "Hsp90aa1", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P82995", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P82995" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "P82995", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P82995" } ] } ] }, { "uniprot_ac": "P97687", "gene_name": "Entpd1", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 H(+) + 2 phosphate.", "evidence": [ { "id": "P97687", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97687" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "P97687", "database": "UniProtKB", "url": 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"evidence": [ { "id": "Q4G005", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4G005" } ] } ] }, { "uniprot_ac": "Q5BJS0", "gene_name": "Dhx30", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "Q5BJS0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5BJS0" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q5BJS0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5BJS0" } ] } ] }, { "uniprot_ac": "Q5EB68", "gene_name": "Ak6", "activity": [ { "ec_number": "2.7.4.3", "activity": "AMP + ATP = 2 ADP.", "evidence": [ { "id": "Q5EB68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5EB68" } ] }, { "ec_number": "2.7.4.3", "activity": "", "evidence": [ { "id": "Q5EB68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5EB68" } ] } ] }, { "uniprot_ac": "Q5EBA1", "gene_name": "Supv3l1", "activity": [ { "ec_number": 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