{ "uniprot_canonical_ac": "A6IXU7-1", "uniprot_ac": "A6IXU7", "uniprot_id": "A6IXU7_RAT", "mass": { "chemical_mass": 50059.0, "monoisotopic_mass": 50059.0 }, "refseq": { "ac": "NP_001020846", "name": "tubulin beta-6 chain", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020846" }, "gene_names": [ { "name": "Tubb6", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A6IXU7", "id": "A6IXU7" }, { "name": "RGD1305887", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020846", "id": "NP_001020846" }, { "name": "Tubb6", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020846", "id": "NP_001020846" } ], "protein_names": [ { "name": "Tubulin beta chain", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprotkb/A6IXU7/entry#names_and_taxonomy", "id": "A6IXU7" }, { "name": "tubulin beta-6 chain", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020846", "id": "NP_001020846" } ], "function": [ { "annotation": "Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZT08", "url": "https://www.uniprot.org/uniprot/A0A8I5ZT08#function" }, { "database": "UniProtKB", "id": "RU000352", "url": "https://www.uniprot.org/uniprot/RU000352#function" }, { "database": "UniProtKB", "id": "A6IXU7", "url": "https://www.uniprot.org/uniprot/A6IXU7#function" } ] } ], "disease": [ { "disease_id": "DOID:0050997", "recommended_name": { "id": "DOID:0050997", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050997", "name": "cerebellar ataxia, mental retardation and dysequlibrium syndrome", "description": "An syndrome characterized by congenital onset of nonprogressive cerebellar ataxia, disturbed equilibrium, and mental retardation, associated with cerebellar hypoplasia." }, "synonyms": [ { "id": "DOID:0050997", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050997", "name": "CAMRQ", "description": "" }, { "id": "DOID:0050997", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050997", "name": "Cerebellar Ataxia, Mental Retardation, and Dysequilibrium Syndrome 1 (CAMRQ1)", "description": "" }, { "id": "DOID:0050997", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050997", "name": "Uner Tan syndrome", "description": "" }, { "id": "DOID:0050997", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050997", "name": "VLDLR Cerebellar Hypoplasia", "description": "" }, { "id": "MONDO:0014104", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014104", "name": "cerebellar ataxia, intellectual disability, and dysequilibrium syndrome 4", "description": "Any dysequilibrium syndrome in which the cause of the disease is a mutation in the ATP8A2 gene." }, { "id": "MONDO:0014104", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014104", "name": "ATP8A2 dysequilibrium syndrome", "description": "" }, { "id": "MONDO:0014104", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014104", "name": "cerebellar ataxia, intellectual disability, and dysequilibrium syndrome 4", "description": "" }, { "id": "MONDO:0014104", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014104", "name": "cerebellar ataxia, intellectual disability, and dysequilibrium syndrome type 4", "description": "" }, { "id": "MONDO:0014104", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014104", "name": "cerebellar ataxia, mental retardation, and dysequilibrium syndrome 4", "description": "" }, { "id": "MONDO:0014104", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014104", "name": "cerebellar ataxia, mental retardation, and dysequilibrium syndrome type 4", "description": "" }, { "id": "MONDO:0014104", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014104", "name": "dysequilibrium syndrome caused by mutation in ATP8A2", "description": "" }, { "id": "MONDO:0014104", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014104", "name": "CAMRQ4", "description": "" }, { "id": "MONDO:0014104", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014104", "name": "cerebellar ataxia and intellectual disability with or without quadrupedal locomotion 4", "description": "" }, { "id": "MONDO:0014104", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014104", "name": "cerebellar ataxia and mental retardation with or without quadrupedal locomotion 4", "description": "" }, { "id": "MONDO:0024542", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0024542", "name": "cerebellar ataxia, intellectual disability, and dysequilibrium syndrome 1", "description": "Any dysequilibrium syndrome in which the cause of the disease is a mutation in the VLDLR gene." }, { "id": "MONDO:0024542", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0024542", "name": "VLDLR dysequilibrium syndrome", "description": "" }, { "id": "MONDO:0024542", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0024542", "name": "cerebellar ataxia, intellectual disability, and dysequilibrium syndrome 1", "description": "" }, { "id": "MONDO:0024542", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0024542", "name": "cerebellar ataxia, intellectual disability, and dysequilibrium syndrome type 1", "description": "" }, { "id": "MONDO:0024542", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0024542", "name": "cerebellar ataxia, mental retardation, and dysequilibrium syndrome type 1", "description": "" }, { "id": "MONDO:0024542", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0024542", "name": "cerebellar hypoplasia and mental retardation with or without quadrupedal locomotion 1", "description": "" }, { "id": "MONDO:0024542", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0024542", "name": "dysequilibrium syndrome caused by mutation in VLDLR", "description": "" }, { "id": "MONDO:0024542", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0024542", "name": "CAMRQ1", "description": "" }, { "id": "MONDO:0024542", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0024542", "name": "cerebellar ataxia and intellectual disability with or without quadrupedal locomotion 1", "description": "" }, { "id": "MONDO:0024542", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0024542", "name": "cerebellar ataxia and mental retardation with or without quadrupedal locomotion 1", "description": "" }, { "id": "MONDO:0024542", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0024542", "name": "cerebellar ataxia, congenital, and intellectual disability, autosomal recessive", "description": "" }, { "id": "MONDO:0024542", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0024542", "name": "cerebellar ataxia, congenital, and mental retardation, autosomal recessive", "description": "" }, { "id": "MONDO:0024542", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0024542", "name": "cerebellar ataxia, mental retardation, and dysequilibrium syndrome 1", "description": "" }, { "id": "MONDO:0024542", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0024542", "name": "cerebellar hypoplasia, VLDLR-associated", "description": "" }, { "id": "MONDO:0024542", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0024542", "name": "dysequilibrium syndrome", "description": "" }, { "id": "MONDO:0013188", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013188", "name": "cerebellar ataxia, intellectual disability, and dysequilibrium syndrome 3", "description": "Any dysequilibrium syndrome in which the cause of the disease is a mutation in the CA8 gene." }, { "id": "MONDO:0013188", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013188", "name": "CA8 dysequilibrium syndrome", "description": "" }, { "id": "MONDO:0013188", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013188", "name": "cerebellar ataxia, intellectual disability, and dysequilibrium syndrome 3", "description": "" }, { "id": "MONDO:0013188", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013188", "name": "cerebellar ataxia, intellectual disability, and dysequilibrium syndrome type 3", "description": "" }, { "id": "MONDO:0013188", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013188", "name": "cerebellar ataxia, mental retardation, and dysequilibrium syndrome 3", "description": "" }, { "id": "MONDO:0013188", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013188", "name": "cerebellar ataxia, mental retardation, and dysequilibrium syndrome type 3", "description": "" }, { "id": "MONDO:0013188", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013188", "name": "dysequilibrium syndrome caused by mutation in CA8", "description": "" }, { "id": "MONDO:0013188", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013188", "name": "CAMRQ3", "description": "" }, { "id": "MONDO:0013188", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013188", "name": "cerebellar ataxia and intellectual disability with or without quadrupedal locomotion 3", "description": "" }, { "id": "MONDO:0013188", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013188", "name": "cerebellar ataxia and mental retardation with or without quadrupedal locomotion 3", "description": "" }, { "id": "MONDO:0012430", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012430", "name": "cerebellar ataxia, intellectual disability, and dysequilibrium syndrome 2", "description": "Any dysequilibrium syndrome in which the cause of the disease is a mutation in the WDR81 gene." }, { "id": "MONDO:0012430", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012430", "name": "WDR81 dysequilibrium syndrome", "description": "" }, { "id": "MONDO:0012430", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012430", "name": "cerebellar ataxia, intellectual disability, and dysequilibrium syndrome 2", "description": "" }, { "id": "MONDO:0012430", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012430", "name": "cerebellar ataxia, intellectual disability, and dysequilibrium syndrome type 2", "description": "" }, { "id": "MONDO:0012430", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012430", "name": "cerebellar ataxia, mental retardation, and dysequilibrium syndrome 2", "description": "" }, { "id": "MONDO:0012430", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012430", "name": "cerebellar ataxia, mental retardation, and dysequilibrium syndrome type 2", "description": "" }, { "id": "MONDO:0012430", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012430", "name": "dysequilibrium syndrome caused by mutation in WDR81", "description": "" }, { "id": "MONDO:0012430", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012430", "name": "CAMRQ2", "description": "" }, { "id": "MONDO:0012430", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012430", "name": "cerebellar ataxia and intellectual disability with or without quadrupedal locomotion 2", "description": "" }, { "id": "MONDO:0012430", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012430", "name": "cerebellar ataxia and mental retardation with or without quadrupedal locomotion 2", "description": "" }, { "id": "MIM:615268", "resource": "MIM", "url": "https://www.omim.org/entry/615268", "name": "Cerebellar ataxia, impaired intellectual development, and dysequilibrium syndrome 4", "description": "Cerebellar ataxia, impaired intellectual development, and dysequilibrium syndrome 4" }, { "id": "MIM:224050", "resource": "MIM", "url": "https://www.omim.org/entry/224050", "name": "Cerebellar ataxia, impaired intellectual development, and dysequilibrium syndrome 1", "description": "Cerebellar ataxia, impaired intellectual development, and dysequilibrium syndrome 1" }, { "id": "MIM:613227", "resource": "MIM", "url": "https://www.omim.org/entry/613227", "name": "Cerebellar ataxia, impaired intellectual development, and dysequilibrium syndrome 3", "description": "Cerebellar ataxia, impaired intellectual development, and dysequilibrium syndrome 3" }, { "id": "MIM:610185", "resource": "MIM", "url": "https://www.omim.org/entry/610185", "name": "Cerebellar ataxia, impaired intellectual development, and dysequilibrium syndrome 2", "description": "Cerebellar ataxia, impaired intellectual development, and dysequilibrium syndrome 2" } ], "evidence": [ { "id": "0050997", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0050997" } ] }, { "disease_id": "DOID:0060260", "recommended_name": { "id": "DOID:0060260", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0060260", "name": "ptosis", "description": "An eye disease characterized by the drooping or falling of the upper or lower eyelid." }, "synonyms": [ { "id": "DOID:0060260", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0060260", "name": "blepharoptosis", "description": "" }, { "id": "DOID:0060260", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0060260", "name": "drooping eyelid", "description": "" } ], "evidence": [ { "id": "0060260", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0060260" } ] }, { "disease_id": "DOID:0090132", "recommended_name": { "id": "DOID:0090132", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0090132", "name": "complex cortical dysplasia with other brain malformations 7", "description": "A complex cortical dysplasia with other brain malformations that is characterized by abnormalities in coritcal brain development that has_material_basis_in autosomal dominant inheritance of heterozygous mutation in the tubulin beta 2B class IIb (TUBB2B) gene on chromosome 6p25." }, "synonyms": [ { "id": "DOID:0090132", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0090132", "name": "CDCBM7", "description": "" }, { "id": "DOID:0090132", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0090132", "name": "polymicrogyria due to TUBB2B mutation", "description": "" }, { "id": "MONDO:0012399", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012399", "name": "complex cortical dysplasia with other brain malformations 7", "description": "Any complex cortical dysplasia with other brain malformations in which the cause of the disease is a mutation in the TUBB2B gene." }, { "id": "MONDO:0012399", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012399", "name": "CDCBM7", "description": "" }, { "id": "MONDO:0012399", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012399", "name": "TUBB2B complex cortical dysplasia with other brain malformations", "description": "" }, { "id": "MONDO:0012399", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012399", "name": "complex cortical dysplasia with other brain malformations caused by mutation in TUBB2B", "description": "" }, { "id": "MONDO:0012399", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012399", "name": "complex cortical dysplasia with other brain malformations type 7", "description": "" }, { "id": "MONDO:0012399", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012399", "name": "polymicrogyria due to TUBB2B mutation", "description": "" }, { "id": "MONDO:0012399", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012399", "name": "PMGYSA", "description": "" }, { "id": "MONDO:0012399", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012399", "name": "cortical dysplasia, COMPLEX, with OTHER brain malformations 7", "description": "" }, { "id": "MONDO:0012399", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012399", "name": "cortical dysplasia, Complex, with Other brain malformations 7", "description": "" }, { "id": "MONDO:0012399", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012399", "name": "polymicrogyria, symmetric or asymmetric", "description": "" }, { "id": "MIM:610031", "resource": "MIM", "url": "https://www.omim.org/entry/610031", "name": "Cortical dysplasia, complex, with other brain malformations 7", "description": "Cortical dysplasia, complex, with other brain malformations 7" } ], "evidence": [ { "id": "0090132", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0090132" } ] }, { "disease_id": "DOID:0112227", "recommended_name": { "id": "DOID:0112227", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0112227", "name": "tubulinopathy", "description": "A congenital nervous system abnormality characterized by complex cortical malformations including in most cases dysmorphic basal ganglia that has_material_basis_in mutation in one or more of the tubulin genes." }, "synonyms": 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norvegicus [10116]" } ], "gene": [ { "name": "Tubb6", "url": "https://www.uniprot.org/uniprot/A6IXU7", "locus": { "chromosome": "18", "start_pos": 60954418, "end_pos": 60943375, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000018371", "url": "https://www.ensembl.org/id/ENSRNOG00000018371" } ] } } ], "crossref": [ { "id": "ENSRNOG00000018371", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000018371", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd02187", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd02187", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "307351", "url": "https://www.ncbi.nlm.nih.gov/gene/307351", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "A6IXU7", "url": "https://www.ebi.ac.uk/intact/interactors/id:A6IXU7*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR000217", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000217", 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"https://www.ebi.ac.uk/interpro/entry/IPR023123", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036525", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036525", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037103", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037103", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "rno:307351", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:307351", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "ESCDYLQ", "url": "https://omabrowser.org/oma/group/ESCDYLQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "3124041at2759", "url": "http://www.orthodb.org/?query=3124041at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11588", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11588", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11588:SF88", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11588:SF88", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00091", "url": "http://pfam.xfam.org/family/PF00091", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF03953", "url": "http://pfam.xfam.org/family/PF03953", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "NP_001020846", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020846", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "1305887", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1305887", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "A0A8I5ZT08", "url": "https://www.uniprot.org/uniprot/A0A8I5ZT08", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I5ZT08-1", "url": "https://www.uniprot.org/uniprot/A0A8I5ZT08-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A6IXU7", "url": "https://www.uniprot.org/uniprot/A6IXU7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A6IXU7-1", "url": "https://www.uniprot.org/uniprot/A6IXU7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MREIVHIQAGQCGNQIGTKFWEVISDEHGIDPAGGYVGDSALQLERISVYYNESSSKKYVPRAALVDLEPGTMDSVRSGPFGQLFRPDNFIFGQTGAGNNWAKGHYTEGAELVDSVLDVVRKECEHCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVMPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTSLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTARGSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVATVFRGPMSMKEVDEQMLAIQNKNSSYFVEWIPNNVKVAVCDIPPRGLKMASTFIGNSTAIQELFKRISEQFSAMFRRKAFLHWFTGEGMDEMEFTEAESNMNDLVSEYQQYQDATVNDGEEAFEDEDEEEINE", "length": 447, "header": "tr|A6IXU7-1|A6IXU7_RAT Isoform 1 of Tubulin beta chain OS=Rattus norvegicus OX=10116 GN=Tubb6 PE=1 SV=1 CANONICAL=A6IXU7-1" }, "isoforms": [ { "isoform_ac": "A0A8I5ZT08-1", "url": "https://www.uniprot.org/uniprotkb/A6IXU7/entry#A0A8I5ZT08-1", "sequence": { "sequence": "MREIVHIQAGQCGNQIVWEVISDEHGIDPAGGYVGDSALQLERISVYYNESSSKKYVPRAALVDLEPGTMDSVRSGPFGQLFRPDNFIFGQTGAGNNWAKGHYTEGAELVDSVLDVVRKECEHCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVMPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTSLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTARGSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVATVFRGPMSMKEVDEQMLAIQNKNSSYFVEWIPNNVKVAVCDIPPRGLKMASTFIGNSTAIQELFKRISEQFSAMFRRKAFLHWFTGEGMDEMEFTEAESNMNDLVSEYQQYQDATVNDGEEAFEDEDEEEINE", "length": 444, "header": "tr|A0A8I5ZT08-1|A0A8I5ZT08_RAT Computationally mapped isoform of Tubulin beta chain OS=Rattus norvegicus OX=10116 GN=Tubb6 PE=1 SV=1 CANONICAL=A6IXU7-1" }, "locus": { "chromosome": "18", "start_pos": 60952652, "end_pos": 60943425, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000107745.1", "url": "https://www.ensembl.org/id/ENSRNOT00000107745.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000081460.1", "url": "https://www.ensembl.org/id/ENSRNOP00000081460.1" } ] } }, { "isoform_ac": "A6IXU7-1", "url": "https://www.uniprot.org/uniprotkb/A6IXU7/entry#A6IXU7-1", "sequence": { "sequence": "MREIVHIQAGQCGNQIGTKFWEVISDEHGIDPAGGYVGDSALQLERISVYYNESSSKKYVPRAALVDLEPGTMDSVRSGPFGQLFRPDNFIFGQTGAGNNWAKGHYTEGAELVDSVLDVVRKECEHCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVMPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTSLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTARGSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVATVFRGPMSMKEVDEQMLAIQNKNSSYFVEWIPNNVKVAVCDIPPRGLKMASTFIGNSTAIQELFKRISEQFSAMFRRKAFLHWFTGEGMDEMEFTEAESNMNDLVSEYQQYQDATVNDGEEAFEDEDEEEINE", "length": 447, "header": "tr|A6IXU7-1|A6IXU7_RAT Isoform 1 of Tubulin beta chain OS=Rattus norvegicus OX=10116 GN=Tubb6 PE=1 SV=1 CANONICAL=A6IXU7-1" }, "locus": { "chromosome": "18", "start_pos": 60952652, "end_pos": 60943425, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000024947.5", "url": "https://www.ensembl.org/id/ENSRNOT00000024947.5" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000024947.3", "url": "https://www.ensembl.org/id/ENSRNOP00000024947.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "rno:307351", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:307351", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287B749-1", "protein_name": "Tubulin beta chain", "gene_name": "TUBB6", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MREIVHIQAGQCGNQIGTKFWEVISDEHGIDPAGGYVGDSALQLERINVYYNESSSQKYVPRAALVDLEPGTMDSVRSGPFGQLFRPDNFIFGQTGAGNNWAKGHYTEGAELMDSVLDVVRKESEHCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEFPDRIMNTFSVMPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTSLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTARGSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVATVFRGPMSMKEVDEQMLAIQNKNSSYFVEWIPNNVKVAVCDIPPCGLKMAATFIGNSTAIQELFKRISEQFSAMFPAQGLPALVHGRGHGRDGVHRG", "length": 411 }, "evidence": [ { "id": "A6IXU7", "url": "https://omabrowser.org/oma/group/A6IXU7/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8V0X9Y1-1", "protein_name": "Tubulin beta chain", "gene_name": "TUBB6", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MREIVHIQAGQCGNQIGTKFWEVISDEHGIDPAGGYVGDSALQLERINVYYNESSSQKYVPRAVLVDLEPGTMDSVRSGPFGQLFRPDNFIFGQTGAGNNWAKGHYTEGAELVDSVLDVVRKECEHCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVMPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTSLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTARGSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVATVFRGPMSMKEVDEQMLAIQNKNSSYFVEWIPNNVKVAVCDIPPRGLKMASTFIGNSTAIQELFKRISEQFSAMFRRKAFLHWFTGEGMDEMEFTEAESNMNDLVSEYQQYQEATANDGEETFEDDEEEINE", "length": 446 }, "evidence": [ { "id": "A6IXU7", "url": "https://omabrowser.org/oma/group/A6IXU7/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q922F4-1", "protein_name": "Tubulin beta-6 chain", "gene_name": "Tubb6", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MREIVHIQAGQCGNQIGTKFWEVISDEHGIDQAGGYVGDSALQLERISVYYNESSSKKYVPRAALVDLEPGTMDSVRSGPFGQLFRPDNFIFGQTGAGNNWAKGHYTEGAELVDSVLDVVRKECEHCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVMPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTSLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTARGSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVATVFRGPMSMKEVDEQMLAIQNKNSSYFVEWIPNNVKVAVCDIPPRGLKMASTFIGNSTAIQELFKRISEQFSAMFRRKAFLHWFTGEGMDEMEFTEAESNMNDLVSEYQQYQDATVNDGEEAFEDEDEEEINE", "length": 447 }, "evidence": [ { "id": "46368454", "url": "http://www.informatics.jax.org/homology/46368454", "database": "MGI" }, { "id": "A6IXU7", "url": "https://omabrowser.org/oma/group/A6IXU7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9BUF5-1", "protein_name": "Tubulin beta-6 chain", "gene_name": "TUBB6", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MREIVHIQAGQCGNQIGTKFWEVISDEHGIDPAGGYVGDSALQLERINVYYNESSSQKYVPRAALVDLEPGTMDSVRSGPFGQLFRPDNFIFGQTGAGNNWAKGHYTEGAELVDAVLDVVRKECEHCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEFPDRIMNTFSVMPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTSLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDARNMMAACDPRHGRYLTVATVFRGPMSMKEVDEQMLAIQSKNSSYFVEWIPNNVKVAVCDIPPRGLKMASTFIGNSTAIQELFKRISEQFSAMFRRKAFLHWFTGEGMDEMEFTEAESNMNDLVSEYQQYQDATANDGEEAFEDEEEEIDG", "length": 446 }, "evidence": [ { "id": "46368454", "url": "http://www.informatics.jax.org/homology/46368454", "database": "MGI" }, { "id": "A6IXU7", "url": "https://omabrowser.org/oma/group/A6IXU7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "mitotic cell cycle", "id": "GO:0000278", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000278", "evidence": [ { "database": "UniProtKB", "id": "A6IXU7", "url": "https://www.uniprot.org/uniprot/A6IXU7" } ], "pmid": "" }, { "name": "microtubule cytoskeleton organization", "id": "GO:0000226", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000226", "evidence": [ { "database": "UniProtKB", "id": "A6IXU7", "url": "https://www.uniprot.org/uniprot/A6IXU7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "GTPase activity", "id": "GO:0003924", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003924", "evidence": [ { "database": "UniProtKB", "id": "A6IXU7", "url": "https://www.uniprot.org/uniprot/A6IXU7" } ], "pmid": "" }, { "name": "structural constituent of cytoskeleton", "id": "GO:0005200", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005200", "evidence": [ { "database": "UniProtKB", "id": "A6IXU7", "url": "https://www.uniprot.org/uniprot/A6IXU7" } ], "pmid": "" }, { "name": "GTP binding", "id": "GO:0005525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005525", "evidence": [ { "database": "UniProtKB", "id": "A6IXU7", "url": "https://www.uniprot.org/uniprot/A6IXU7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A6IXU7", "url": "https://www.uniprot.org/uniprot/A6IXU7" } ], "pmid": "" }, { "name": "microtubule", "id": "GO:0005874", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005874", "evidence": [ { "database": "UniProtKB", "id": "A6IXU7", "url": "https://www.uniprot.org/uniprot/A6IXU7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 184, "end_pos": 186, "annotation": "n_glycosylation_sequon" }, { "start_pos": 337, "end_pos": 339, "annotation": "n_glycosylation_sequon" }, { "start_pos": 370, "end_pos": 372, "annotation": "n_glycosylation_sequon" }, { "start_pos": 52, "end_pos": 54, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 184, "end_pos": 186 }, { "start_pos": 337, "end_pos": 339 }, { "start_pos": 370, "end_pos": 372 }, { "start_pos": 52, "end_pos": 54 } ] }, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": 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"table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }