{ "uniprot_canonical_ac": "A6IRJ8-1", "uniprot_ac": "A6IRJ8", "uniprot_id": "A6IRJ8_RAT", "mass": { "chemical_mass": 52379.0, "monoisotopic_mass": 52379.0 }, "refseq": { "ac": "NP_001020573", "name": "uridine 5'-monophosphate synthase", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020573" }, "gene_names": [ { "name": "Umps", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A6IRJ8", "id": "A6IRJ8" }, { "name": "Umps", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020573", "id": "NP_001020573" } ], "protein_names": [ { "name": "Uridine 5'-monophosphate synthase", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprotkb/A6IRJ8/entry#names_and_taxonomy", "id": "A6IRJ8" }, { "name": "2.4.2.10", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A6IRJ8/entry#names_and_taxonomy", "id": "A6IRJ8" }, { "name": "4.1.1.23", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A6IRJ8/entry#names_and_taxonomy", "id": "A6IRJ8" }, { "name": "uridine 5'-monophosphate synthase", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020573", "id": "NP_001020573" }, { "name": "uridine monophosphate synthase", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020573", "id": "NP_001020573" } ], "function": [], "disease": [ { "disease_id": "DOID:0050833", "recommended_name": { "id": "DOID:0050833", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050833", "name": "orotic aciduria", "description": "A pyrimidine metabolic disorder that is characterized by an excessive secretion of orotic acid in urine." }, "synonyms": [ { "id": "MONDO:0009797", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009797", "name": "orotic aciduria", "description": "An extremely rare autosomal recessive inherited disorder caused by mutations in the UMPS gene. It is characterized by deficiency of the activity of the pyrimidine pathway enzyme uridine 5'-monophosphate (UMP) synthase. Clinical manifestations include growth retardation, anemia, and increased excretion of orotic acid in the urine." }, { "id": "MONDO:0009797", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009797", "name": "Hereditary Orotic Aciduria", "description": "" }, { "id": "MONDO:0009797", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009797", "name": "orotic aciduria", "description": "" }, { "id": "MONDO:0009797", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009797", "name": "oroticaciduria", "description": "" }, { "id": "MONDO:0009797", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009797", "name": "orotidylic decarboxylase deficiency", "description": "" }, { "id": "MONDO:0009797", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009797", "name": "uridine monophosphate synthetase deficiency", "description": "" }, { "id": "MONDO:0009797", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009797", "name": "OPRT and ODC deficiency", "description": "" }, { "id": "MONDO:0009797", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009797", "name": "UMP synthtase deficiency", "description": "" }, { "id": "MONDO:0009797", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009797", "name": "UMPS", "description": "" }, { "id": "MONDO:0009797", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009797", "name": "Ump synthase deficiency", "description": "" }, { "id": "MONDO:0009797", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009797", "name": "Umps deficiency", "description": "" }, { "id": "MONDO:0009797", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009797", "name": "hereditary orotic aciduria", "description": "" }, { "id": "MONDO:0009797", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009797", "name": "orotate phosphoribosyltransferase and OMP decarboxylase deficiency", "description": "" }, { "id": "MONDO:0009797", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009797", "name": "orotate phosphoribosyltransferase and orotidylic decarboxylase deficiency", "description": "" }, { "id": "MONDO:0009797", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009797", "name": "orotic aciduria 1", "description": "" }, { "id": "MONDO:0009797", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009797", "name": "orotic aciduria II (formerly)", "description": "" }, { "id": "MONDO:0009797", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009797", "name": "orotic aciduria type 1", "description": "" }, { "id": "MONDO:0009797", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009797", "name": "orotic aciduria without megaloblastic Anaemia", "description": "" }, { "id": "MONDO:0009797", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009797", "name": "orotic aciduria without megaloblastic Anemia", "description": "" }, { "id": "MONDO:0009797", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009797", "name": "oroticaciduria 1", "description": "" }, { "id": "MONDO:0009797", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009797", "name": "orotidylic pyrophosphorylase and orotidylic decarboxylase deficiency", "description": "" }, { "id": "MONDO:0009797", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009797", "name": "uridine monophosphate synthase deficiency", "description": "" }, { "id": "MIM:258900", "resource": "MIM", "url": "https://www.omim.org/entry/258900", "name": "Orotic aciduria 1", "description": "Orotic aciduria 1" } ], "evidence": [ { "id": "0050833", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0050833" } ] }, { "disease_id": "DOID:653", "recommended_name": { "id": "DOID:653", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:653", "name": "purine-pyrimidine metabolic disorder", "description": "An inherited metabolic disorder involving dysfunction of purine and pyrimidine metabolism." }, "synonyms": [ { "id": "DOID:653", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:653", "name": "inborn errors of purine-pyrimidine metabolism", "description": "" } ], "evidence": [ { "id": "653", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:653" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "A6IRJ8", "url": "https://www.uniprot.org/uniprot/A6IRJ8" } ], "common_name": "Rat", "glygen_name": "Rat", "reference_species": "Rattus norvegicus [10116]" } ], "gene": [ { "name": "Umps", "url": "https://www.uniprot.org/uniprot/A6IRJ8", "locus": { "chromosome": "11", "start_pos": 66821903, "end_pos": 66806045, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000001797", "url": "https://www.ensembl.org/id/ENSRNOG00000001797" } ] } } ], "crossref": [ { "id": "ENSRNOG00000001797", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000001797", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd04725", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04725", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd06223", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06223", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "288051", "url": "https://www.ncbi.nlm.nih.gov/gene/288051", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000836", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000836", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001754", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001754", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004467", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004467", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011060", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011060", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013785", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013785", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014732", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014732", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018089", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018089", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023031", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023031", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029057", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029057", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "rno:288051", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:288051", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "SAKHVCG", "url": "https://omabrowser.org/oma/group/SAKHVCG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "922at2759", "url": "http://www.orthodb.org/?query=922at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR19278", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19278", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR19278:SF9", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19278:SF9", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00156", "url": "http://pfam.xfam.org/family/PF00156", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF00215", "url": "http://pfam.xfam.org/family/PF00215", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-500753", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-500753", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_001020573", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020573", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "1311908", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1311908", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "A6IRJ8", "url": "https://www.uniprot.org/uniprot/A6IRJ8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A6IRJ8-1", "url": "https://www.uniprot.org/uniprot/A6IRJ8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F7FPV0", "url": "https://www.uniprot.org/uniprot/F7FPV0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F7FPV0-1", "url": "https://www.uniprot.org/uniprot/F7FPV0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEVARQALGPLVTELYDVQAFKFGSFVLKSGLSSPVYIDLRGIVSRPRLLSQVADILFQTARNAGISFDSVCGVPYTALPLATVICSANHIPMLIRRKETKDYGTKRLVEGEINPGQTCLVIEDVVTSGASVLETVEVLQKEGLKVTDAIVLLDREQGGKDKLQAQGIRLHSVCTLSEMLEILEQQKKIDAEMVGRVKRFIQENVFTAANHNGVPPPEKKACKELSFGARAELPGVHPLASKLLTLMQKKETNLCLSADVSEARELLQLADALGPSICMLKTHVDILNDFTLDVMEELTTLAKRHEFLIFEDRKFADIGNTVKKQYESGIFKIASWADVVNAHVVPGSGVVKGLQEVGLPLHRACLLIAEMSSAGSLATGDYTKAAVGMAEEHCEFVIGFISGSRVSMKPEFLHLTPGVQLETGGDHLGQQYNSPQEVVGKRGSDVIIVGRGILAAANRLEAAEMYRKAAWEAYLSRLAVQ", "length": 481, "header": "tr|A6IRJ8-1|A6IRJ8_RAT Isoform 1 of Uridine 5'-monophosphate synthase OS=Rattus norvegicus OX=10116 GN=Umps PE=1 SV=1 CANONICAL=A6IRJ8-1" }, "isoforms": [ { "isoform_ac": "A6IRJ8-1", "url": "https://www.uniprot.org/uniprotkb/A6IRJ8/entry#A6IRJ8-1", "sequence": { "sequence": "MEVARQALGPLVTELYDVQAFKFGSFVLKSGLSSPVYIDLRGIVSRPRLLSQVADILFQTARNAGISFDSVCGVPYTALPLATVICSANHIPMLIRRKETKDYGTKRLVEGEINPGQTCLVIEDVVTSGASVLETVEVLQKEGLKVTDAIVLLDREQGGKDKLQAQGIRLHSVCTLSEMLEILEQQKKIDAEMVGRVKRFIQENVFTAANHNGVPPPEKKACKELSFGARAELPGVHPLASKLLTLMQKKETNLCLSADVSEARELLQLADALGPSICMLKTHVDILNDFTLDVMEELTTLAKRHEFLIFEDRKFADIGNTVKKQYESGIFKIASWADVVNAHVVPGSGVVKGLQEVGLPLHRACLLIAEMSSAGSLATGDYTKAAVGMAEEHCEFVIGFISGSRVSMKPEFLHLTPGVQLETGGDHLGQQYNSPQEVVGKRGSDVIIVGRGILAAANRLEAAEMYRKAAWEAYLSRLAVQ", "length": 481, "header": "tr|A6IRJ8-1|A6IRJ8_RAT Isoform 1 of Uridine 5'-monophosphate synthase OS=Rattus norvegicus OX=10116 GN=Umps PE=1 SV=1 CANONICAL=A6IRJ8-1" }, "locus": { "chromosome": "11", "start_pos": 66816357, "end_pos": 66806111, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000117390.1", "url": "https://www.ensembl.org/id/ENSRNOT00000117390.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000085385.1", "url": "https://www.ensembl.org/id/ENSRNOP00000085385.1" } ] } }, { "isoform_ac": "F7FPV0-1", "url": "https://www.uniprot.org/uniprotkb/A6IRJ8/entry#F7FPV0-1", "sequence": { "sequence": "MEVARQALGPLVTELYDVQAFKFGSFVLKSGLSSPVYIDLRGIVSRPRLLSQVADILFQTARNAGISFDSVCGVPYTALPLATVICSANHIPMLIRRKETKDYGTKRLVEGEINPGQTCLVIEDVVTSGASVLETVEVLQKEGLKVTDAIVLLDREQGGKDKLQAQGIRLHSVCTLSEMLEILEQQKKIDAEMVGRVKRFIQENVFTAANHNGVPPPEKKACKELSFGARAELPGVHPLASKLLTLMQKKETNLCLSADVSEARELLQLADALGPSICMLKTHVDILNDFTLDVMEELTTLAKRHEFLIFEDRKFADIGNTVKKQYESGIFKIASWADVVNAHVVPGSGVVKGLQEVGLPLHRACLLIAEMSSAGSLATGDYTKAAVGMAEEHCEFVIGFISGSRVSMKPEFLHLTPGVQLETGGDHLGQQYNSPQEVVGKRGSDVIIVGRGILAAANRLEAAEMYRKAAWEAYLSFTAVNRHHDQGKSYKNSM", "length": 494, "header": "tr|F7FPV0-1|F7FPV0_RAT Computationally mapped isoform of Uridine 5'-monophosphate synthase OS=Rattus norvegicus OX=10116 GN=Umps PE=1 SV=1 CANONICAL=A6IRJ8-1" }, "locus": { "chromosome": "11", "start_pos": 66821664, "end_pos": 66806111, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000002450.7", "url": "https://www.ensembl.org/id/ENSRNOT00000002450.7" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000002450.6", "url": "https://www.ensembl.org/id/ENSRNOP00000002450.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "rno:288051", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:288051", "resource": "KEGG Pathway" }, { "id": "R-RNO-500753", "name": "Pyrimidine biosynthesis", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-500753", "resource": "Reactome", "description": "Pyrimidine biosynthesis" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A5G2RBV3-1", "protein_name": "Uridine 5'-monophosphate synthase", "gene_name": "UMPS", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAAADVALASLVTGLYDVQAFKFGSFVLKSGLSSPVYIDLRGIVSRPRLLSQVAEILFQTAQNAGINFDTVCGVPYTALPLATVICSTNQIPMLIRRKEAKDYGTKRLIEGAVNPGETCLIIEDVVTSGSSILETVEVLQKEGLKVTDAIVVLDREQGGRDKLQAHGIRLHSVCTLSNMLEILEQQKKIDAEMVERVKRFIQENVFVVANHNGSLPSAKKAPKELSFGTRAELPGIHPVASKLLRLMQKKETNLCLSADISESRELLQLADALGPSICMLKTHVDILNDFTPDVMKELTTLAKRHEFLIFEDRKFADIGNTVKKQYAGGVFKIASWADIVNAHVVPGSGVVKGLREVGLPLHRACLLIAEMSSAGSLATGSYTEAAVRMAEEHSEFVVGFISGSRVSMKPEFLHLTPGVQLEAGGDNLGQQYNSPQEVIGKRGSDIIIVGRGILMSANRLEAAEKYRKAAWEAYLSRLAV", "length": 480 }, "evidence": [ { "id": "A6IRJ8", "url": "https://omabrowser.org/oma/group/A6IRJ8/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8V0ZCP5-1", "protein_name": "Uridine 5'-monophosphate synthase", "gene_name": "UMPS", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAAGGAGRVAAALLEARAVRFGDFVLRSGIASPVYVDLRGLASRPSLLRLVADLLFQTAKDAALQYDCVCGVPYTALPLATIISSENQIPMLIRRKEAKDYGTKRLVEGTINPGETCLIIEDVVTSGSSVLETAEVLRKEGLKVTDAVVLLDREQGGKARLEEHGIRLHSVCTLSGMLDILQQQGEVDVEMVEKVKNFIQGNVFEPGAQNGPTPVKRVCKELSFRARAELPGVHPVAARLLTLMEKKQTNLCLSADVTGSKELLQLAASLGPSICILKTHIDILNDFTQEVVKELRALADQHEFLIFEDRKFADIGNTVKHQYEGGVFKIASWSDVVNAHVVPGSGVVKGLKEVGLPLQRGCLLIAEMSSQGSLATGEYTKAAVQMAEDNPDFVFGFISGSRVSDKPEFLHLTPGVQLQAGGDNLGQKYLSPKEVISEKGSDIIIVGRGILSASDRLQEAEKYRKAAWESYISRLGVHA", "length": 479 }, "evidence": [ { "id": "A6IRJ8", "url": "https://omabrowser.org/oma/group/A6IRJ8/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "P09556-1", "protein_name": "Uridine 5'-monophosphate synthase", "gene_name": "pyr56", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MNIKELVLKLNEIDAIKLGEFKLKSGIISPIYIDLRVTVSSPPLLAAIAEMMYQKVYKSGNAQETPALVCGVPYTALPIATGMSIANNIPMVVRRKEAKAYGTKQLIEGRFKEGDNVLVVEDLVTSGASVLETVRDLNSVGLKVTDVVVLLDRQQGARQALEKQGYRLHSVFTMEELINTLIEAGKLTGRTLELVQSFLDANRNVVVPLPPTLAPPAPAPIVINKPFEERAKLASNPMASKLFTLMSSKKTNLAVAADLTDKQQLLDLAESIGSEICVLKTHVDIIDNYDEEFIKSLKCIAAKHNFLIFEDRKFADIGNTVKYQFENGVYKISKWADMVTVHGVAGSSIVDGFKSGLKEYGSGLLLLAQMSSKGSLCVGDYTTQMIEMANNNKEEVMGLICQERLPSMTDGLVLMTPGVQFNSTGDAMGQQYNTPEYIIKEKNTDVIIVGRGIYQSNDPKSVANKYRTAAWETYQSKF", "length": 478 }, "evidence": [ { "id": "A6IRJ8", "url": "https://omabrowser.org/oma/group/A6IRJ8/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "P11172-1", "protein_name": "Uridine 5'-monophosphate synthase", "gene_name": "UMPS", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAVARAALGPLVTGLYDVQAFKFGDFVLKSGLSSPIYIDLRGIVSRPRLLSQVADILFQTAQNAGISFDTVCGVPYTALPLATVICSTNQIPMLIRRKETKDYGTKRLVEGTINPGETCLIIEDVVTSGSSVLETVEVLQKEGLKVTDAIVLLDREQGGKDKLQAHGIRLHSVCTLSKMLEILEQQKKVDAETVGRVKRFIQENVFVAANHNGSPLSIKEAPKELSFGARAELPRIHPVASKLLRLMQKKETNLCLSADVSLARELLQLADALGPSICMLKTHVDILNDFTLDVMKELITLAKCHEFLIFEDRKFADIGNTVKKQYEGGIFKIASWADLVNAHVVPGSGVVKGLQEVGLPLHRGCLLIAEMSSTGSLATGDYTRAAVRMAEEHSEFVVGFISGSRVSMKPEFLHLTPGVQLEAGGDNLGQQYNSPQEVIGKRGSDIIIVGRGIISAADRLEAAEMYRKAAWEAYLSRLGV", "length": 480 }, "evidence": [ { "id": "46362806", "url": "http://www.informatics.jax.org/homology/46362806", "database": "MGI" }, { "id": "A6IRJ8", "url": "https://omabrowser.org/oma/group/A6IRJ8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P13439-1", "protein_name": "Uridine 5'-monophosphate synthase", "gene_name": "Umps", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEVASQALGPLVTELYDVQAFKFGSFVLKSGLSSPVYIDLRGIVSRPRLLSQVADILFQTAKNAGISFDSVCGVPYTALPLATVICSANHIPMLIRRKETKDYGTKRLVEGEINPGQTCLVIEDVVTSGASVLETVEVLQKEGLKVTDAIVLLDREQGGKDKLQAQGIRLHAVCTLSQMLEILQQQEKIDADMVGRVKRFIQENVFSAANHNGLPPPEKKACKELSFGARAELPGTHPLASKLLRLMQKKETNLCLSADVSEARELLQLADALGPSICMLKTHVDILNDFTLDVMEELTALAKRHEFLIFEDRKFADIGNTVKKQYESGTFKIASWADIVNAHVVPGSGVVKGLQEVGLPLHRACLLIAEMSSAGSLATGNYTKAAVGMAEEHCEFVIGFISGSRVSMKPEFLHLTPGVQLETGGDHLGQQYNSPQEVIGKRGSDVIIVGRGILAAANRLEAAEMYRKAAWEAYLSRLAVQ", "length": 481 }, "evidence": [ { "id": "46362806", "url": "http://www.informatics.jax.org/homology/46362806", "database": "MGI" }, { "id": "A6IRJ8", "url": "https://omabrowser.org/oma/group/A6IRJ8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q01637-1", "protein_name": "Uridine 5'-monophosphate synthase", "gene_name": "r-l", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MVAQNSDKMRALALKLFEINAFKFGDFKMKVGINSPVYFDLRVIVSYPDVMQTVSDLLVEHIKDKQLSAKHVCGVPYTALPLATIVSVQQGTPMLVRRKEAKAYGTKKLVEGIFNAGDTCLIVEDVVTSGSSILDTVRDLQGEGIVVTDAVVVVDREQGGVANIAKHGVRMHSLFTLSFLLNTLHEAGRIEKSTVEAVAKYIAAVQINSDGTFVGGDKGDVVRANDLQRTKLTYENRANLAKSAVAKRLFNLIASKQTNLCLAADLTHADEILDVADKCGPYICLLKTHVDIVEDFSDKFIADLQALAQRHNFLLMEDRKFADIGNTVSLQYGKGIYKISSWADLVTAHTLPGRSILQGLKAGLGEGGAGKERGVFLLAEMSASGNLIDAKYKENSNKIATEGADVDFVAGVVCQSSDAFAFPGLLQLTPGVKIDEGVDQLGQQYQSPEHVVKERGADIGVVGRGILKASSPKQAAQTYRDRLWAAYQDRVAK", "length": 493 }, "evidence": [ { "id": "A6IRJ8", "url": "https://omabrowser.org/oma/group/A6IRJ8/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A6IRJ8", "url": "https://www.uniprot.org/uniprot/A6IRJ8" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A6IRJ8", "url": "https://www.uniprot.org/uniprot/A6IRJ8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 8, "go_terms": [ { "name": "cellular response to xenobiotic stimulus", "id": "GO:0071466", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071466", "evidence": [ { "database": "UniProtKB", "id": "A6IRJ8", "url": "https://www.uniprot.org/uniprot/A6IRJ8" } ], "pmid": "" }, { "name": "female pregnancy", "id": "GO:0007565", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007565", "evidence": [ { "database": "UniProtKB", "id": "A6IRJ8", "url": "https://www.uniprot.org/uniprot/A6IRJ8" } ], "pmid": "" }, { "name": "lactation", "id": "GO:0007595", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007595", "evidence": [ { "database": "UniProtKB", "id": "A6IRJ8", "url": "https://www.uniprot.org/uniprot/A6IRJ8" } ], "pmid": "" }, { "name": "UMP biosynthetic process", "id": "GO:0006222", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006222", "evidence": [ { "database": "UniProtKB", "id": "A6IRJ8", "url": "https://www.uniprot.org/uniprot/A6IRJ8" } ], "pmid": "" }, { "name": "'de novo' pyrimidine nucleobase biosynthetic process", "id": "GO:0006207", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006207", "evidence": [ { "database": "UniProtKB", "id": "A6IRJ8", "url": "https://www.uniprot.org/uniprot/A6IRJ8" } ], "pmid": "" }, { "name": "'de novo' UMP biosynthetic process", "id": "GO:0044205", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044205", "evidence": [ { "database": "UniProtKB", "id": "A6IRJ8", "url": "https://www.uniprot.org/uniprot/A6IRJ8" } ], "pmid": "" }, { "name": "pyrimidine nucleobase biosynthetic process", "id": "GO:0019856", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019856", "evidence": [ { "database": "UniProtKB", "id": "A6IRJ8", "url": "https://www.uniprot.org/uniprot/A6IRJ8" } ], "pmid": "" }, { "name": "UDP biosynthetic process", "id": "GO:0006225", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006225", "evidence": [ { "database": "UniProtKB", "id": "A6IRJ8", "url": "https://www.uniprot.org/uniprot/A6IRJ8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "orotate phosphoribosyltransferase activity", "id": "GO:0004588", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004588", "evidence": [ { "database": "UniProtKB", "id": "A6IRJ8", "url": "https://www.uniprot.org/uniprot/A6IRJ8" } ], "pmid": "" }, { "name": "orotidine-5'-phosphate decarboxylase activity", "id": "GO:0004590", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004590", "evidence": [ { "database": "UniProtKB", "id": "A6IRJ8", "url": "https://www.uniprot.org/uniprot/A6IRJ8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "R-RNO-73564", "name": "UMPS dimer decarboxylates OMP to UMP", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [ "R-ALL-111629" ], "output_participant_list": [], "enzyme_list": [ "A6IRJ8-1" ], "evidence": [ { "id": "R-RNO-73564", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-73564" } ] }, { "id": "R-RNO-73567", "name": "UMPS dimer transfers phosphoribosyl group to ORO to form OMP", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [ "R-ALL-76632" ], "output_participant_list": [], "enzyme_list": [ "A6IRJ8-1" ], "evidence": [ { "id": "R-RNO-73567", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-73567" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-111629", "participant_name": "OMP [cytosol]", "crossref": [ { "id": "C01103", "database": "COMPOUND", "url": "" }, { "id": "57538", "database": "ChEBI", "url": "" }, { "id": "000004095542", "database": "ZINC", "url": "" }, { "id": "C01103", "database": "COMPOUND", "url": "" }, { "id": "000004095542", "database": "ZINC", "url": "" }, { "id": "57538", "database": "ChEBI", "url": "" }, { "id": "C01103", "database": "COMPOUND", "url": "" }, { "id": "57538", "database": "ChEBI", "url": "" }, { "id": "000004095542", "database": "ZINC", "url": "" }, { "id": "000004095542", "database": "ZINC", "url": "" }, { "id": "C01103", "database": "COMPOUND", "url": "" }, { "id": "57538", "database": "ChEBI", "url": "" }, { "id": "C01103", "database": "COMPOUND", "url": "" }, { "id": "57538", "database": "ChEBI", "url": "" }, { "id": "000004095542", "database": "ZINC", "url": "" }, { "id": "C01103", "database": "COMPOUND", "url": "" }, { "id": "57538", "database": "ChEBI", "url": "" }, { "id": "000004095542", "database": "ZINC", "url": "" } ] }, { "participant_id": "R-ALL-76632", "participant_name": "ORO [cytosol]", "crossref": [ { "id": "C00295", "database": "COMPOUND", "url": "" }, { "id": "30839", "database": "ChEBI", "url": "" }, { "id": "000001408068", "database": "ZINC", "url": "" }, { "id": "C00295", "database": "COMPOUND", "url": "" }, { "id": "30839", "database": "ChEBI", "url": "" }, { "id": "000001408068", "database": "ZINC", "url": "" }, { "id": "C00295", "database": "COMPOUND", "url": "" }, { "id": "30839", "database": "ChEBI", "url": "" }, { "id": "000001408068", "database": "ZINC", "url": "" }, { "id": "30839", "database": "ChEBI", "url": "" }, { "id": "000001408068", "database": "ZINC", "url": "" }, { "id": "C00295", "database": "COMPOUND", "url": "" }, { "id": "C00295", "database": "COMPOUND", "url": "" }, { "id": "30839", "database": "ChEBI", "url": "" }, { "id": "000001408068", "database": "ZINC", "url": "" }, { "id": "C00295", "database": "COMPOUND", "url": "" }, { "id": "30839", "database": "ChEBI", "url": "" }, { "id": "000001408068", "database": "ZINC", "url": "" }, { "id": "C00295", "database": "COMPOUND", "url": "" }, { "id": "30839", "database": "ChEBI", "url": "" }, { "id": "000001408068", "database": "ZINC", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A6IRJ8", "gene_name": "Umps", "activity": [ { "ec_number": "2.4.2.10", "activity": "diphosphate + orotidine 5'-phosphate = 5-phospho-alpha-D-ribose 1-diphosphate + orotate.", "evidence": [ { "id": "A6IRJ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A6IRJ8" } ] }, { "ec_number": "4.1.1.23", "activity": "H(+) + orotidine 5'-phosphate = CO2 + UMP.", "evidence": [ { "id": "A6IRJ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A6IRJ8" } ] }, { "ec_number": "4.1.1.23", "activity": "", "evidence": [ { "id": "A6IRJ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A6IRJ8" } ] }, { "ec_number": "2.4.2.10", "activity": "", "evidence": [ { "id": "A6IRJ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A6IRJ8" } ] } ] } ], "biomarkers": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.4.2.10", "ec_name": "diphosphate + orotidine 5'-phosphate = 5-phospho-alpha-D-ribose 1-diphosphate + orotate.", "evidence": [ { "id": "2.4.2.10", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.10" }, { "id": "2.4.2.10", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.4.2.10" } ] }, { "ec_number": "4.1.1.23", "ec_name": "H(+) + orotidine 5'-phosphate = CO2 + UMP.", "evidence": [ { "id": "4.1.1.23", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.23" }, { "id": "4.1.1.23", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=4.1.1.23" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }