{ "uniprot_canonical_ac": "A6HZ09-1", "uniprot_ac": "A6HZ09", "uniprot_id": "A6HZ09_RAT", "mass": { "chemical_mass": 48310.0, "monoisotopic_mass": 48310.0 }, "refseq": { "ac": "NP_001121014", "name": "E3 ubiquitin-protein ligase pellino homolog 3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001121014" }, "gene_names": [ { "name": "Peli3", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A6HZ09", "id": "A6HZ09" }, { "name": "Peli3", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001121014", "id": "NP_001121014" }, { "name": "RGD1305989", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001121014", "id": "NP_001121014" } ], "protein_names": [ { "name": "E3 ubiquitin-protein ligase pellino homolog", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprotkb/A6HZ09/entry#names_and_taxonomy", "id": "A6HZ09" }, { "name": "2.3.2.27", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A6HZ09/entry#names_and_taxonomy", "id": "A6HZ09" }, { "name": "E3 ubiquitin-protein ligase pellino homolog 3", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001121014", "id": "NP_001121014" }, { "name": "pellino homolog 3; protein pellino homolog 3; pellino 3", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001121014", "id": "NP_001121014" } ], "function": [ { "annotation": "E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.", "evidence": [ { "database": "UniProtKB", "id": "A6HZ09", "url": "https://www.uniprot.org/uniprot/A6HZ09#function" }, { "database": "UniProtKB", "id": "PIRNR038886", "url": "https://www.uniprot.org/uniprot/PIRNR038886#function" }, { "database": "UniProtKB", "id": "A0A8I6AFG2", "url": "https://www.uniprot.org/uniprot/A0A8I6AFG2#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "A6HZ09", "url": "https://www.uniprot.org/uniprot/A6HZ09" } ], "common_name": "Rat", "glygen_name": "Rat", "reference_species": "Rattus norvegicus [10116]" } ], "gene": [ { "name": "Peli3", "url": "https://www.uniprot.org/uniprot/A6HZ09", "locus": { "chromosome": "1", "start_pos": 202232228, "end_pos": 202242857, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000019950", "url": "https://www.ensembl.org/id/ENSRNOG00000019950" } ] } } ], "crossref": [ { "id": "ENSRNOG00000019950", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000019950", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "309157", "url": "https://www.ncbi.nlm.nih.gov/gene/309157", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR006800", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006800", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048334", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048334", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048335", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048335", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "rno:309157", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:309157", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "VICERWP", "url": "https://omabrowser.org/oma/group/VICERWP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "4002880at2759", "url": "http://www.orthodb.org/?query=4002880at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12098", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12098", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12098:SF9", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12098:SF9", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04710", "url": "http://pfam.xfam.org/family/PF04710", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF20723", "url": "http://pfam.xfam.org/family/PF20723", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "NP_001121014", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001121014", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "1305989", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1305989", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "A0A8I6AFG2", "url": "https://www.uniprot.org/uniprot/A0A8I6AFG2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6AFG2-1", "url": "https://www.uniprot.org/uniprot/A0A8I6AFG2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A6HZ09", "url": "https://www.uniprot.org/uniprot/A6HZ09", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A6HZ09-1", "url": "https://www.uniprot.org/uniprot/A6HZ09-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVLEGNPEVGSPRTSDLQHPGDKGSCILSSPGEEALPGEEPIKYGELIVLGYNGCLSSGDKGRRRSRLALSRRPHANGVKPDVMHHISTPLVSKALSNRGQHSISYTLSRSHSVIVEYTHDSDKDMFQIGRSTENMIDFVVTDTSPGGGTTEGPSAQSTISRYACRILCDRRPPYTARIYAAGFDASSNIFLGERAAKWRTPDGLMDGLTTNGVLVMHPAGGFSEDSAPGVWREISVCGNVYELRDSRSAQQRGKLVENESNVLQDGSLIDLCGATLLWRTPAGLLRAPTLKQLEAQRQEANAARPQCPVGLSTLAFPSPARGRTAPDKQQPWVYVRCGHVHGYHGWGCRRERGPQERECPLCRLVGPYVPLWLGQEAGLCLDPGPPSHAFAPCGHVCSEKTARYWAQTPLPHGTHAFHAACPFCGAWLTGELGCVRLIFQGPLD", "length": 445, "header": "tr|A6HZ09-1|A6HZ09_RAT Isoform 1 of E3 ubiquitin-protein ligase pellino homolog OS=Rattus norvegicus OX=10116 GN=Peli3 PE=2 SV=1 CANONICAL=A6HZ09-1" }, "isoforms": [ { "isoform_ac": "A0A8I6AFG2-1", "url": "https://www.uniprot.org/uniprotkb/A6HZ09/entry#A0A8I6AFG2-1", "sequence": { "sequence": "MVLEGNPEVGSPRTSDLQHPGDKGSCILSSPGEEALPGEEPIKYGELIVLGYNGCLSSGDKGRRRSRLALSRRPHANGVKPDVMHHISTPLVSKIGRSTENMIDFVVTDTSPGGGTTEGPSAQSTISRYACRILCDRRPPYTARIYAAGFDASSNIFLGERAAKWRTPDGLMDGLTTNGVLVMHPAGGFSEDSAPGVWREISVCGNVYELRDSRSAQQRGKLVENESNVLQDGSLIDLCGATLLWRTPAGLLRAPTLKQLEAQRQEANAARPQCPVGLSTLAFPSPARGRTAPDKQQPWVYVRCGHVHGYHGWGCRRERGPQERECPLCRLVGPYVPLWLGQEAGLCLDPGPPSHAFAPCGHVCSEKTARYWAQTPLPHGTHAFHAACPFCGAWLTGELGCVRLIFQGPLD", "length": 411, "header": "tr|A0A8I6AFG2-1|A0A8I6AFG2_RAT Computationally mapped isoform of E3 ubiquitin-protein ligase pellino homolog OS=Rattus norvegicus OX=10116 GN=Peli3 PE=3 SV=1 CANONICAL=A6HZ09-1" }, "locus": { "chromosome": "1", "start_pos": 202241678, "end_pos": 202232644, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000097970.1", "url": "https://www.ensembl.org/id/ENSRNOT00000097970.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000091360.1", "url": "https://www.ensembl.org/id/ENSRNOP00000091360.1" } ] } }, { "isoform_ac": "A6HZ09-1", "url": "https://www.uniprot.org/uniprotkb/A6HZ09/entry#A6HZ09-1", "sequence": { "sequence": "MVLEGNPEVGSPRTSDLQHPGDKGSCILSSPGEEALPGEEPIKYGELIVLGYNGCLSSGDKGRRRSRLALSRRPHANGVKPDVMHHISTPLVSKALSNRGQHSISYTLSRSHSVIVEYTHDSDKDMFQIGRSTENMIDFVVTDTSPGGGTTEGPSAQSTISRYACRILCDRRPPYTARIYAAGFDASSNIFLGERAAKWRTPDGLMDGLTTNGVLVMHPAGGFSEDSAPGVWREISVCGNVYELRDSRSAQQRGKLVENESNVLQDGSLIDLCGATLLWRTPAGLLRAPTLKQLEAQRQEANAARPQCPVGLSTLAFPSPARGRTAPDKQQPWVYVRCGHVHGYHGWGCRRERGPQERECPLCRLVGPYVPLWLGQEAGLCLDPGPPSHAFAPCGHVCSEKTARYWAQTPLPHGTHAFHAACPFCGAWLTGELGCVRLIFQGPLD", "length": 445, "header": "tr|A6HZ09-1|A6HZ09_RAT Isoform 1 of E3 ubiquitin-protein ligase pellino homolog OS=Rattus norvegicus OX=10116 GN=Peli3 PE=2 SV=1 CANONICAL=A6HZ09-1" }, "locus": { "chromosome": "1", "start_pos": 202241678, "end_pos": 202232644, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000027038.4", "url": "https://www.ensembl.org/id/ENSRNOT00000027038.4" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000027038.2", "url": "https://www.ensembl.org/id/ENSRNOP00000027038.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "rno:309157", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:309157", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "K7GS70-1", "protein_name": "E3 ubiquitin-protein ligase pellino homolog", "gene_name": "PELI3", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MVLEGNPEVGSPRTSDLQHPENQGSCILSSPGEDAQPGEEPIKYGELIVLGYNGCLASGDKGRRRSRLALNRRPHANGVKPDVMHHISTPLVSKALSNRGQHSISYTLSRSHSVIVEYTHDSDTDMFQIGRSTENMIDFVVTDTSPGGGAAEGPSAQSTISRYACRILCDRRPPYTARIYAAGFDASSNIFLGERAAKWRTPDGLMDGLTTNGVLVMHPAGGFSEDSAPGVWREISVCGNVYTLRDSRSAQQRGKLVENESNVLQDGSLIDLCGATLLWRTPAGLLRAPTLKQLEAQRQEANAARPQCPVGLSTLAFPSPARGRTAPDKQQPWVYVRCGHVHGYHGWGCRRERGPQERECPLCRLVGPYVPLWLGQEAGLCLDPGPPSHAFAPCGHVCSEKTARYWAQTPLPHGTHAFHAACPFCGAWLTGEHGCVRLIFQGPLD", "length": 445 }, "evidence": [ { "id": "A6HZ09", "url": "https://omabrowser.org/oma/group/A6HZ09/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q8BXR6-1", "protein_name": "E3 ubiquitin-protein ligase pellino homolog 3", "gene_name": "Peli3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MVLEGNPDVGSPRTSDLQHPGSQGSCILSCPGEEALAGEEPIKYGELIVLGYNGCLASGDKGRRRSRLALSRRPHANGVKPDVMHHISTPLVSKALSNRGQHSISFTLSRSHSVIVEYTHDSDKDMFQIGRSTENMIDFVVTDTSPGGGATEGPSAQSTISRYACRILCDRRPPYTARIYAAGFDASSNIFLGERAAKWRTPDGLMDGLTTNGVLVMHPAGGFSEDSAPGVWREISVCGNVYTLRDSRSAQQRGKLVENESNVLQDGSLIDLCGATLLWRTPAGLLRAPTLKQLEAQRQEANAARPQCPVGLSTLAFPSPARGRTAPDKQQPWVYVRCGHVHGYHGWGCRRERGPQERECPLCRLVGPYVPLWLGQEAGLCLDPGPPSHAFAPCGHVCSEKTARYWAQTPLPHGTHAFHAACPFCGAWLTGELGCVRLIFQGPLD", "length": 445 }, "evidence": [ { "id": "46370629", "url": "http://www.informatics.jax.org/homology/46370629", "database": "MGI" }, { "id": "A6HZ09", "url": "https://omabrowser.org/oma/group/A6HZ09/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8N2H9-1", "protein_name": "E3 ubiquitin-protein ligase pellino homolog 3", "gene_name": "PELI3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MVLEGNPEVGSPRTSDLQHRGNKGSCVLSSPGEDAQPGEEPIKYGELIVLGCCEEGGEETEAQRGEVTGPRAHSCYNGCLASGDKGRRRSRLALSRRSHANGVKPDVMHHISTPLVSKALSNRGQHSISYTLSRSHSVIVEYTHDSDTDMFQIGRSTENMIDFVVTDTSPGGGAAEGPSAQSTISRYACRILCDRRPPYTARIYAAGFDASSNIFLGERAAKWRTPDGLMDGLTTNGVLVMHPAGGFSEDSAPGVWREISVCGNVYTLRDSRSAQQRGKLVENESNVLQDGSLIDLCGATLLWRTPAGLLRAPTLKQLEAQRQEANAARPQCPVGLSTLAFPSPARGRTAPDKQQPWVYVRCGHVHGYHGWGCRRERGPQERECPLCRLVGPYVPLWLGQEAGLCLDPGPPSHAFAPCGHVCSEKTARYWAQTPLPHGTHAFHAACPFCGAWLTGEHGCVRLIFQGPLD", "length": 469 }, "evidence": [ { "id": "46370629", "url": "http://www.informatics.jax.org/homology/46370629", "database": "MGI" }, { "id": "A6HZ09", "url": "https://omabrowser.org/oma/group/A6HZ09/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 9, "go_terms": [ { "name": "regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway", "id": "GO:0070428", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070428", "evidence": [ { "database": "UniProtKB", "id": "A6HZ09", "url": "https://www.uniprot.org/uniprot/A6HZ09" } ], "pmid": "" }, { "name": "defense response to Gram-negative bacterium", "id": "GO:0050829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050829", "evidence": [ { "database": "UniProtKB", "id": "A6HZ09", "url": "https://www.uniprot.org/uniprot/A6HZ09" } ], "pmid": "" }, { "name": "negative regulation of extrinsic apoptotic signaling pathway", "id": "GO:2001237", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2001237", "evidence": [ { "database": "UniProtKB", "id": "A6HZ09", "url": "https://www.uniprot.org/uniprot/A6HZ09" } ], "pmid": "" }, { "name": "negative regulation of protein ubiquitination", "id": "GO:0031397", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031397", "evidence": [ { "database": "UniProtKB", "id": "A6HZ09", "url": "https://www.uniprot.org/uniprot/A6HZ09" } ], "pmid": "" }, { "name": "negative regulation of tumor necrosis factor-mediated signaling pathway", "id": "GO:0010804", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010804", "evidence": [ { "database": "UniProtKB", "id": "A6HZ09", "url": "https://www.uniprot.org/uniprot/A6HZ09" } ], "pmid": "" }, { "name": "protein K63-linked ubiquitination", "id": "GO:0070534", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070534", "evidence": [ { "database": "UniProtKB", "id": "A6HZ09", "url": "https://www.uniprot.org/uniprot/A6HZ09" } ], "pmid": "" }, { "name": "negative regulation of type I interferon production", "id": "GO:0032480", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032480", "evidence": [ { "database": "UniProtKB", "id": "A6HZ09", "url": "https://www.uniprot.org/uniprot/A6HZ09" } ], "pmid": "" }, { "name": "positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway", "id": "GO:0070434", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070434", "evidence": [ { "database": "UniProtKB", "id": "A6HZ09", "url": "https://www.uniprot.org/uniprot/A6HZ09" } ], "pmid": "" }, { "name": "negative regulation of Toll signaling pathway", "id": "GO:0045751", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045751", "evidence": [ { "database": "UniProtKB", "id": "A6HZ09", "url": "https://www.uniprot.org/uniprot/A6HZ09" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "ubiquitin protein ligase activity", "id": "GO:0061630", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061630", "evidence": [ { "database": "UniProtKB", "id": "A6HZ09", "url": "https://www.uniprot.org/uniprot/A6HZ09" } ], "pmid": "" }, { "name": "ubiquitin-protein transferase activity", "id": "GO:0004842", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004842", "evidence": [ { "database": "UniProtKB", "id": "A6HZ09", "url": "https://www.uniprot.org/uniprot/A6HZ09" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 259, "end_pos": 261, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.3.2.27", "ec_name": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "2.3.2.27", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.3.2.27" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 259, "end_pos": 261 } ] }, "section_stats": [ { "table_id": 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"sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }