{ "uniprot_canonical_ac": "A6H6J2-1", "uniprot_ac": "A6H6J2", "uniprot_id": "A6H6J2_MOUSE", "mass": { "chemical_mass": 55846.0, "monoisotopic_mass": 55846.0 }, "refseq": { "ac": "NP_031839", "name": "cytochrome P450, family 2, subfamily b, polypeptide 13 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031839" }, "gene_names": [ { "name": "Cyp2b13", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A6H6J2", "id": "A6H6J2" }, { "name": "Cyp2b13", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031839", "id": "NP_031839" } ], "protein_names": [ { "name": "Cytochrome P450", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprotkb/A6H6J2/entry#names_and_taxonomy", "id": "A6H6J2" }, { "name": "1.14.14.1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A6H6J2/entry#names_and_taxonomy", "id": "A6H6J2" }, { "name": "cytochrome P450, family 2, subfamily b, polypeptide 13 precursor", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031839", "id": "NP_031839" }, { "name": "phenobarbital inducible, type c; cytochrome P450, 2b13, phenobarbitol inducible, type c", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031839", "id": "NP_031839" } ], "function": [ { "annotation": "Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.", "evidence": [ { "database": "UniProtKB", "id": "A6H6J2", "url": "https://www.uniprot.org/uniprot/A6H6J2#function" }, { "database": "UniProtKB", "id": "RU368046", "url": "https://www.uniprot.org/uniprot/RU368046#function" }, { "database": "UniProtKB", "id": "ARBA00037347", "url": "https://www.uniprot.org/uniprot/ARBA00037347#function" } ] }, { "annotation": "Report lentiviral-mediated RNAi knockdown of multiple mouse Cyp2b enzymes.", "evidence": [ { "database": "RefSeq", "id": "NP_031839", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031839" }, { "database": "PubMed", "id": "22083726", "url": "https://glygen.org/publication/PubMed/22083726" } ] } ], "disease": [ { "disease_id": "DOID:0050742", "recommended_name": { "id": "DOID:0050742", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050742", "name": "nicotine dependence", "description": "A substance dependence that is characterized by a physical dependence on nicotine." }, "synonyms": [ { "id": "DOID:0050742", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050742", "name": "tobacco use disorder", "description": "" } ], "evidence": [ { "id": "0050742", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0050742" } ] }, { "disease_id": "DOID:399", "recommended_name": { "id": "DOID:399", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:399", "name": "tuberculosis", "description": "A primary bacterial infectious disease that is located_in lungs, located_in lymph nodes, located_in pericardium, located_in brain, located_in pleura or located_in gastrointestinal tract, has_material_basis_in Mycobacterium tuberculosis, which is transmitted_by droplets released into the air when an infected person coughs or sneezes." }, "synonyms": [], "evidence": [ { "id": "399", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:399" } ] }, { "disease_id": "DOID:526", "recommended_name": { "id": "DOID:526", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:526", "name": "human immunodeficiency virus infectious disease", "description": "A viral infectious disease that results in destruction of immune system, leading to life-threatening opportunistic infections and cancers, has_material_basis_in Human immunodeficiency virus 1 or has_material_basis_in Human immunodeficiency virus 2, which are transmitted by sexual contact, transmitted by transfer of blood, semen, vaginal fluid, pre-ejaculate, or breast milk, transmitted by congenital method, and transmitted by contaminated needles. The virus infects helper T cells (CD4+ T cells) which are directly or indirectly destroyed, macrophages, and dendritic cells. The infection has symptom diarrhea, has symptom fatigue, has symptom fever, has symptom vaginal yeast infection, has symptom headache, has symptom mouth sores, has symptom muscle aches, has symptom sore throat, and has symptom swollen lymph glands." }, "synonyms": [ { "id": "DOID:526", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:526", "name": "HIV infection", "description": "" } ], "evidence": [ { "id": "526", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:526" } ] }, { "disease_id": "DOID:9119", "recommended_name": { "id": "DOID:9119", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9119", "name": "acute myeloid leukemia", "description": "A myeloid leukemia that is characterized by the rapid growth of abnormal white blood cells that accumulate in the bone marrow and interfere with the production of normal blood cells." }, "synonyms": [ { "id": "DOID:9119", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9119", "name": "AML - acute Myeloid Leukemia", "description": "" }, { "id": "DOID:9119", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9119", "name": "Leukemia, Myelocytic, acute", "description": "" }, { "id": "DOID:9119", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9119", "name": "acute myeloblastic leukaemia", "description": "" }, { "id": "DOID:9119", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9119", "name": "acute myeloblastic leukemia", "description": "" }, { "id": "DOID:9119", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9119", "name": "acute myelogenous leukaemia", "description": "" }, { "id": "DOID:9119", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9119", "name": "acute myelogenous leukemia", "description": "" }, { "id": "DOID:9119", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9119", "name": "acute myeloid leukaemia", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "acute myeloid leukemia", "description": "Acute myeloid leukemia (AML) is a group of neoplasms arising from precursor cells committed to the myeloid cell-line differentiation. All of them are characterized by clonal expansion of myeloid blasts. AML manifests by fever, pallor, anemia, hemorrhages and recurrent infections." }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "AML", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "AML - acute myeloid leukaemia", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "AML - acute myeloid leukemia", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "ANLL", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "acute Nonlymphocytic leukaemia", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "acute Nonlymphocytic leukemia", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "acute granulocytic leukaemia", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "acute granulocytic leukemia", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "acute myeloblastic leukaemia", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "acute myeloblastic leukemia", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "acute myelocytic leukaemia", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "acute myelocytic leukemia", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "acute myelogenous leukaemia", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "acute myelogenous leukemia", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "acute myelogenous leukemias", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "acute myeloid leukaemia (AML)", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "acute myeloid leukemia", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "acute myeloid leukemia (AML)", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "acute myeloid leukemia, somatic", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "acute nonlymphocytic leukaemia", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "acute nonlymphocytic leukemia", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "hematopoeitic - acute Myleogenous leukaemia (AML)", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "hematopoeitic - acute Myleogenous leukemia (AML)", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "leukemia, acute myeloid, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "leukemia, acute myeloid, reduced survival in, somatic", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "leukemia, acute myeloid, somatic", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "leukemia, acute myeloid, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "leukemia, myelocytic, acute", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "myeloid leukemia, acute", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "myeloid leukemia, acute, M4/M4Eo subtype, somatic", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "acute non lymphoblastic leukaemia", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "acute non lymphoblastic leukemia", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "leukemia, acute myelogenous", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "leukemia, acute 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"id": "DOID:9828", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9828", "name": "Drug withdrawal syndrome in newborn", "description": "" } ], "evidence": [ { "id": "9828", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:9828" } ] }, { "disease_id": "DOID:9974", "recommended_name": { "id": "DOID:9974", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9974", "name": "drug dependence", "description": "A substance dependence that involves the continued use of drugs despite problems related to use of the substance." }, "synonyms": [], "evidence": [ { "id": "9974", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:9974" } ] }, { "disease_id": "DOID:9976", "recommended_name": { "id": "DOID:9976", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9976", "name": "heroin dependence", "description": "An opiate dependence that involves the continued use of heroin despite problems related to use of the substance." }, "synonyms": [], "evidence": [ { "id": "9976", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:9976" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "A6H6J2", "url": "https://www.uniprot.org/uniprot/A6H6J2" } ], "common_name": "Mouse", "glygen_name": "Mouse", "reference_species": "Mus musculus [10090]" } ], "gene": [ { "name": "Cyp2b13", "url": "https://www.uniprot.org/uniprot/A6H6J2", "locus": { "chromosome": "7", "start_pos": 25795622, "end_pos": 25760922, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000040583", "url": "https://www.ensembl.org/id/ENSMUSG00000040583" } ] } } ], "crossref": [ { "id": "ENSMUSG00000040583", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000040583", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd20672", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd20672", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "13089", "url": "https://www.ncbi.nlm.nih.gov/gene/13089", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001128", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001128", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002401", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002401", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008068", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008068", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017972", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017972", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036396", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036396", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "mmu:13089", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:13089", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "88599", "url": "http://www.informatics.jax.org/marker/MGI:88599", "database": "MGI", "categories": [ "Organism-specific" ] }, { "id": "GENTHHR", "url": "https://omabrowser.org/oma/group/GENTHHR/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "2900138at2759", "url": "http://www.orthodb.org/?query=2900138at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24300", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24300", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24300:SF366", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24300:SF366", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00067", "url": "http://pfam.xfam.org/family/PF00067", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "NP_031839", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031839", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "17149", "url": "https://www.rhea-db.org/rhea/17149", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A6H6J2", "url": "https://www.uniprot.org/uniprot/A6H6J2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A6H6J2-1", "url": "https://www.uniprot.org/uniprot/A6H6J2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDPSVLLLLAVLLSLFLLLVRGHAKIHGHLPPGPRPLPLLGNLLQMDRGGLLKCFIHLQEKHGDVFTVHLGPRPVVVLCGTQTIREALVNNAEAFSGRGTIAAAQLVMQDYGIFFSSGERWKTLRRFSLATMKEFGMGKRSVEERIKEEAQCLVEELKKYQGAPLDPTFFFQCVTANIICSIVFGERFDYTDEQFLRLLNLMYQIYSLLRSFSCQMFELFSGLLKYFPGVHRQIAKNQQEILNFITHRVEKHRATLDPSEPRDFIDTYLLRMEKEKSNHNTEFHHQNLMMSVLSLFFAGTETTSTTLCCGFLLMLMYPHVAEKVQKEIDQVIGSHRLPTLDDRTKMPYTDAVIHEIQRFSDIVPTGAPHRVTKDTMFRGYLLPKNTEVYPILSSALHDPQYFEQPDSFNPDHFLDANGALKKSEAFLPFSTGKRICLGESIARNELFLFFTSILQNFSVASPVASKDIDLTPKESGIGKIPPTYQICFLAR", "length": 491, "header": "tr|A6H6J2-1|A6H6J2_MOUSE Isoform 1 of Cytochrome P450 OS=Mus musculus OX=10090 GN=Cyp2b13 PE=1 SV=1 CANONICAL=A6H6J2-1" }, "isoforms": [ { "isoform_ac": "A6H6J2-1", "url": "https://www.uniprot.org/uniprotkb/A6H6J2/entry#A6H6J2-1", "sequence": { "sequence": "MDPSVLLLLAVLLSLFLLLVRGHAKIHGHLPPGPRPLPLLGNLLQMDRGGLLKCFIHLQEKHGDVFTVHLGPRPVVVLCGTQTIREALVNNAEAFSGRGTIAAAQLVMQDYGIFFSSGERWKTLRRFSLATMKEFGMGKRSVEERIKEEAQCLVEELKKYQGAPLDPTFFFQCVTANIICSIVFGERFDYTDEQFLRLLNLMYQIYSLLRSFSCQMFELFSGLLKYFPGVHRQIAKNQQEILNFITHRVEKHRATLDPSEPRDFIDTYLLRMEKEKSNHNTEFHHQNLMMSVLSLFFAGTETTSTTLCCGFLLMLMYPHVAEKVQKEIDQVIGSHRLPTLDDRTKMPYTDAVIHEIQRFSDIVPTGAPHRVTKDTMFRGYLLPKNTEVYPILSSALHDPQYFEQPDSFNPDHFLDANGALKKSEAFLPFSTGKRICLGESIARNELFLFFTSILQNFSVASPVASKDIDLTPKESGIGKIPPTYQICFLAR", "length": 491, "header": "tr|A6H6J2-1|A6H6J2_MOUSE Isoform 1 of Cytochrome P450 OS=Mus musculus OX=10090 GN=Cyp2b13 PE=1 SV=1 CANONICAL=A6H6J2-1" }, "locus": { "chromosome": "7", "start_pos": 25795243, "end_pos": 25760945, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000005669.9", "url": "https://www.ensembl.org/id/ENSMUST00000005669.9" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000005669.8", "url": "https://www.ensembl.org/id/ENSMUSP00000005669.8" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Lentiviral-mediated RNAi knockdown yields a novel mouse model for studying Cyp2b function.", "journal": "Toxicological sciences : an official journal of the Society of Toxicology", "date": "2012", "authors": "Damiri B, Holle E, Yu X, Baldwin WS", "evidence": [ { "database": "RefSeq", "id": "NP_031839", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031839" } ], "reference": [ { "type": "PubMed", "id": "22083726", "url": "https://glygen.org/publication/PubMed/22083726" } ] } ], "pathway": [ { "id": "mmu:13089", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:13089", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "P13107-1", "protein_name": "Cytochrome P450 2B3", "gene_name": "Cyp2b3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MDTSVLLLLAVLLSFLLFLVRGHAKVHGHLPPGPRPLPLLGNLLQMDRGGFRKSFIQLQEKHGDVFTVYFGPRPVVMLCGTQTIREALVDHAEAFSGRGIIAVLQPIMQEYGVSFVNEERWKILRRLFVATMRDFGIGKQSVEDQIKEEAKCLVEELKNHQGVSLDPTFLFQCVTGNIICSIVFGERFDYRDRQFLRLLDLLYRTFSLISSFSSQMFEVYSDFLKYFPGVHREIYKNLKEVLDYIDHSVENHRATLDPNAPRDFIDTFLLHMEKEKLNHYTEFHHWNLMISVLFLFLAGTESTSNTLCYGFLLMLKYPHVAEKVQKEIDQVIGSQRVPTLDDRSKMPYTEAVIHEIQRFSDVSPMGLPCRITKDTLFRGYLLPKNTEVYFILSSALHDPQYFEQPDTFNPEHFLDANGALKKCEAFMPFSIGKRMCLGEGIARSELFLFFTTILQNYSVSSPVDPNTIDMTPKESGLAKVAPVYKICFVAR", "length": 491 }, "evidence": [ { "id": "46366247", "url": "http://www.informatics.jax.org/homology/46366247", "database": "MGI" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P20813-1", "protein_name": "Cytochrome P450 2B6", "gene_name": "CYP2B6", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MELSVLLFLALLTGLLLLLVQRHPNTHDRLPPGPRPLPLLGNLLQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASPVAPEDIDLTPQECGVGKIPPTYQIRFLPR", "length": 491 }, "evidence": [ { "id": "46366247", "url": "http://www.informatics.jax.org/homology/46366247", "database": "MGI" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "cellular ketone metabolic process", "id": "GO:0042180", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042180", "evidence": [ { "database": "UniProtKB", "id": "A6H6J2", "url": "https://www.uniprot.org/uniprot/A6H6J2" } ], "pmid": "" }, { "name": "xenobiotic metabolic process", "id": "GO:0006805", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006805", "evidence": [ { "database": "UniProtKB", "id": "A6H6J2", "url": "https://www.uniprot.org/uniprot/A6H6J2" } ], "pmid": "" }, { "name": "xenobiotic catabolic process", "id": "GO:0042178", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042178", "evidence": [ { "database": "UniProtKB", "id": "A6H6J2", "url": "https://www.uniprot.org/uniprot/A6H6J2" } ], "pmid": "" }, { "name": "steroid metabolic process", "id": "GO:0008202", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008202", "evidence": [ { "database": "UniProtKB", "id": "A6H6J2", "url": "https://www.uniprot.org/uniprot/A6H6J2" } ], "pmid": "" }, { "name": "epoxygenase P450 pathway", "id": "GO:0019373", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019373", "evidence": [ { "database": "UniProtKB", "id": "A6H6J2", "url": "https://www.uniprot.org/uniprot/A6H6J2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 12, "go_terms": [ { "name": "aromatase activity", "id": "GO:0070330", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070330", "evidence": [ { "database": "UniProtKB", "id": "A6H6J2", "url": "https://www.uniprot.org/uniprot/A6H6J2" } ], "pmid": "" }, { "name": "iron ion binding", "id": "GO:0005506", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005506", "evidence": [ { "database": "UniProtKB", "id": "A6H6J2", "url": "https://www.uniprot.org/uniprot/A6H6J2" } ], "pmid": "" }, { "name": "heme binding", "id": "GO:0020037", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0020037", "evidence": [ { "database": "UniProtKB", "id": "A6H6J2", "url": "https://www.uniprot.org/uniprot/A6H6J2" } ], "pmid": "" }, { "name": "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen", "id": "GO:0016712", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016712", "evidence": [ { "database": "UniProtKB", "id": "A6H6J2", "url": "https://www.uniprot.org/uniprot/A6H6J2" } ], "pmid": "" }, { "name": "arachidonic acid epoxygenase activity", "id": "GO:0008392", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008392", "evidence": [ { "database": "UniProtKB", "id": "A6H6J2", "url": "https://www.uniprot.org/uniprot/A6H6J2" } ], "pmid": "" }, { "name": "monooxygenase activity", "id": "GO:0004497", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004497", "evidence": [ { "database": "UniProtKB", "id": "A6H6J2", "url": "https://www.uniprot.org/uniprot/A6H6J2" } ], "pmid": "" }, { "name": "estrogen 2-hydroxylase activity", "id": "GO:0101021", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0101021", "evidence": [ { "database": "UniProtKB", "id": "A6H6J2", "url": "https://www.uniprot.org/uniprot/A6H6J2" } ], "pmid": "" }, { "name": "testosterone 16-alpha-hydroxylase activity", "id": "GO:0008390", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008390", "evidence": [ { "database": "UniProtKB", "id": "A6H6J2", "url": "https://www.uniprot.org/uniprot/A6H6J2" } ], "pmid": "" }, { "name": "testosterone 16-beta-hydroxylase activity", "id": "GO:0062184", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0062184", "evidence": [ { "database": "UniProtKB", "id": "A6H6J2", "url": "https://www.uniprot.org/uniprot/A6H6J2" } ], "pmid": "" }, { "name": "anandamide 8,9 epoxidase activity", "id": "GO:0062187", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0062187", "evidence": [ { "database": "UniProtKB", "id": "A6H6J2", "url": "https://www.uniprot.org/uniprot/A6H6J2" } ], "pmid": "" }, { "name": "anandamide 11,12 epoxidase activity", "id": "GO:0062188", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0062188", "evidence": [ { "database": "UniProtKB", "id": "A6H6J2", "url": "https://www.uniprot.org/uniprot/A6H6J2" } ], "pmid": "" }, { "name": "anandamide 14,15 epoxidase activity", "id": "GO:0062189", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0062189", "evidence": [ { "database": "UniProtKB", "id": "A6H6J2", "url": "https://www.uniprot.org/uniprot/A6H6J2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A6H6J2", "url": "https://www.uniprot.org/uniprot/A6H6J2" } ], "pmid": "" }, { "name": "intracellular membrane-bounded organelle", "id": "GO:0043231", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043231", "evidence": [ { "database": "UniProtKB", "id": "A6H6J2", "url": "https://www.uniprot.org/uniprot/A6H6J2" } ], "pmid": "" }, { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "A6H6J2", "url": "https://www.uniprot.org/uniprot/A6H6J2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 456, "end_pos": 458, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "17149", "name": "", "equation": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P20852-1", "O09158-1", "O55071-1", "Q64459-1", "Q64481-1", "O54749-1", "P11714-1", "P15392-1", "Q8CIM7-1", "P24456-1", "P56654-1", "P56655-1", "P56656-1", "P12791-1", "P56593-1", "O54750-1", "Q91WL5-1", "Q91X77-1", "Q64458-1", "P00186-1", "P00184-1", "Q05421-1", "Q6XVG2-1", "Q64429-1", "Q9D816-1", "P12790-1", "P24457-1", "Q9JMA7-1", "Q64462-1", "Q64464-1", "B2RXZ2-1", "D3YYZ0-1", "D3Z2W7-1", "Q9WV19-1", "Q9DBX6-1", "E9Q593-1", "A2A974-1", "Q9EQW4-1", "A6H6J2-1", "B2RXA7-1" ], "evidence": [ { "id": "17149", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/17149" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A2A974", "gene_name": "Cyp4a12b", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "A2A974", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2A974" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "A2A974", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2A974" } ] } ] }, { "uniprot_ac": "A6H6J2", "gene_name": "Cyp2b13", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "A6H6J2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A6H6J2" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "A6H6J2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A6H6J2" } ] } ] }, { "uniprot_ac": "B2RXA7", "gene_name": "Cyp26c1", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "B2RXA7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B2RXA7" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "B2RXA7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B2RXA7" } ] } ] }, { "uniprot_ac": "B2RXZ2", "gene_name": "Cyp2a22", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "B2RXZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B2RXZ2" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "B2RXZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B2RXZ2" } ] } ] }, { "uniprot_ac": "D3YYZ0", "gene_name": "Cyp3a57", "activity": [ { "ec_number": "1.14.14.-", "activity": "", "evidence": [ { "id": "D3YYZ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3YYZ0" } ] } ] }, { "uniprot_ac": "D3Z2W7", "gene_name": "Cyp3a59", "activity": [ { "ec_number": "1.14.14.-", "activity": "", "evidence": [ { "id": "D3Z2W7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3Z2W7" } ] } ] }, { "uniprot_ac": "E9Q593", "gene_name": "Cyp2b23", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "E9Q593", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9Q593" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "E9Q593", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9Q593" } ] } ] }, { "uniprot_ac": "O09158", "gene_name": "Cyp3a25", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "O09158", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O09158" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "O09158", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O09158" } ] }, { "ec_number": "1.14.14.-", "activity": "", "evidence": [ { "id": "O09158", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O09158" } ] } ] }, { "uniprot_ac": "O54749", "gene_name": "Cyp2j5", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "O54749", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54749" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "O54749", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54749" } ] } ] }, { "uniprot_ac": "O54750", "gene_name": "Cyp2j6", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "O54750", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54750" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "O54750", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54750" } ] } ] }, { "uniprot_ac": "O55071", "gene_name": "Cyp2b19", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "O55071", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O55071" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "O55071", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O55071" } ] } ] }, { "uniprot_ac": "P00184", "gene_name": "Cyp1a1", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P00184", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00184" } ] }, { "ec_number": "4.2.1.152", "activity": "(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O.", "evidence": [ { "id": "P00184", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00184" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P00184", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00184" } ] } ] }, { "uniprot_ac": "P00186", "gene_name": "Cyp1a2", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P00186", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00186" } ] }, { "ec_number": "4.2.1.152", "activity": "(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O.", "evidence": [ { "id": "P00186", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00186" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P00186", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00186" } ] } ] }, { "uniprot_ac": "P11714", "gene_name": "Cyp2d9", "activity": [ { "ec_number": "1.14.14.-", "activity": "", "evidence": [ { "id": "P11714", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11714" } ] }, { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P11714", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11714" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P11714", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11714" } ] } ] }, { "uniprot_ac": "P12790", "gene_name": "Cyp2b9", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P12790", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P12790" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P12790", 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