{ "uniprot_canonical_ac": "A2VCW5-1", "uniprot_ac": "A2VCW5", "uniprot_id": "S38A5_RAT", "mass": { "chemical_mass": 52436.0, "monoisotopic_mass": 52436.0 }, "refseq": { "ac": "NP_620209", "name": "sodium-coupled neutral amino acid transporter 5", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620209" }, "gene_names": [ { "name": "Slc38a5", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A2VCW5", "id": "A2VCW5" }, { "name": "SN2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620209", "id": "NP_620209" }, { "name": "Slc38a5", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620209", "id": "NP_620209" }, { "name": "Sn2", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A2VCW5", "id": "A2VCW5" }, { "name": "Snat5", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A2VCW5", "id": "A2VCW5" } ], "protein_names": [ { "name": "Sodium-coupled neutral amino acid transporter 5", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprotkb/A2VCW5/entry#names_and_taxonomy", "id": "A2VCW5" }, { "name": "Solute carrier family 38 member 5", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A2VCW5/entry#names_and_taxonomy", "id": "A2VCW5" }, { "name": "System N transporter 2", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A2VCW5/entry#names_and_taxonomy", "id": "A2VCW5" }, { "name": "sodium-coupled neutral amino acid transporter 5", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620209", "id": "NP_620209" }, { "name": "system N transporter 2; amino acid transporter system N2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620209", "id": "NP_620209" } ], "function": [ { "annotation": "PH-sensitive System A (SNAT2) and System N (SNAT5) amino acid transporter activity allosteric regulation involves a conserved histidine residue", "evidence": [ { "database": "RefSeq", "id": "NP_620209", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620209" }, { "database": "PubMed", "id": "16629640", "url": "https://glygen.org/publication/PubMed/16629640" } ] }, { "annotation": "SN2 doubles as a transmitter precursor furnisher and a potential regulator of NMDA receptors.", "evidence": [ { "database": "RefSeq", "id": "NP_620209", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620209" }, { "database": "PubMed", "id": "22821889", "url": "https://glygen.org/publication/PubMed/22821889" } ] }, { "annotation": "SNAT5/SN2 expression is coordinated with that of other proteins necessary for the operation of glutamatergic synapses", "evidence": [ { "database": "RefSeq", "id": "NP_620209", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620209" }, { "database": "PubMed", "id": "24333324", "url": "https://glygen.org/publication/PubMed/24333324" } ] }, { "annotation": "Symporter that cotransports neutral amino acids and sodium ions, coupled to an H(+) antiporter activity (PubMed:11698233, PubMed:16629640, PubMed:15218073, PubMed:22821889, PubMed:16249471). Releases L-glutamine and glycine from astroglial cells and may participate in the glutamate/GABA-glutamine cycle and the NMDA receptors activation (PubMed:22821889). In addition contributes significantly to L-glutamine uptake in retina, namely in ganglion and Mueller cells and, therefore participates in the retinal glutamate-glutamine cycle (PubMed:16249471). The transport activity is pH sensitive (PubMed:22821889, PubMed:15218073, PubMed:11698233), Li(+) tolerant (PubMed:22821889, PubMed:15218073, PubMed:11698233), bidirectional (PubMed:22821889, PubMed:15218073) and associated with large uncoupled fluxes of protons (PubMed:22821889, PubMed:15218073, PubMed:11698233). The transport is electroneutral coupled to the cotransport of 1 Na(+) and the antiport of 1 H(+) (PubMed:22821889). May have particular importance for modulation of net hepatic glutamine flux (PubMed:15218073).", "evidence": [ { "database": "UniProtKB", "id": "A2VCW5", "url": "https://www.uniprot.org/uniprot/A2VCW5#function" }, { "database": "PubMed", "id": "16629640", "url": "https://glygen.org/publication/PubMed/16629640" }, { "database": "PubMed", "id": "22821889", "url": "https://glygen.org/publication/PubMed/22821889" }, { "database": "PubMed", "id": "11698233", "url": "https://glygen.org/publication/PubMed/11698233" }, { "database": "PubMed", "id": "16249471", "url": "https://glygen.org/publication/PubMed/16249471" }, { "database": "PubMed", "id": "15218073", "url": "https://glygen.org/publication/PubMed/15218073" } ] }, { "annotation": "The effect of lipopolysaccharides on system N expression occurs not only at the protein level, but also at the mRNA level", "evidence": [ { "database": "RefSeq", "id": "NP_620209", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620209" }, { "database": "PubMed", "id": "20036385", "url": "https://glygen.org/publication/PubMed/20036385" } ] }, { "annotation": "This transporter is likely to be involved in glutamatergic pathways in the brain.", "evidence": [ { "database": "RefSeq", "id": "NP_620209", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620209" }, { "database": "PubMed", "id": "15390093", "url": "https://glygen.org/publication/PubMed/15390093" } ] } ], "disease": [], "snv": [], "mutagenesis": [ { "start_pos": 479, "end_pos": 479, "sequence_org": "H", "sequence_mut": "A", "comment": "Modifies the transporter pH-sensitivity.", "evidence": [ { "database": "UniProtKB", "id": "A2VCW5", "url": "https://www.uniprot.org/uniprot/A2VCW5" }, { "database": "PubMed", "id": "16629640", "url": "https://glygen.org/publication/PubMed/16629640" } ] } ], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "A2VCW5", "url": "https://www.uniprot.org/uniprot/A2VCW5" } ], "common_name": "Rat", "glygen_name": "Rat", "reference_species": "Rattus norvegicus [10116]" } ], "gene": [ { "name": "Slc38a5", "url": "https://www.uniprot.org/uniprot/A2VCW5", "locus": { "chromosome": "X", "start_pos": 14213729, "end_pos": 14222498, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000027767", "url": "https://www.ensembl.org/id/ENSRNOG00000027767" } ] } } ], "crossref": [ { "id": "ENSRNOG00000027767", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000027767", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "192208", "url": "https://www.ncbi.nlm.nih.gov/gene/192208", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR013057", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013057", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "rno:192208", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:192208", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "MEVAGEM", "url": "https://omabrowser.org/oma/group/MEVAGEM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "935269at2759", "url": "http://www.orthodb.org/?query=935269at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22950", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22950", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22950:SF74", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22950:SF74", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01490", "url": "http://pfam.xfam.org/family/PF01490", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_A2VCW5", "url": "http://purl.obolibrary.org/obo/PR_A2VCW5", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-RNO-352230", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-352230", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_620209", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620209", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "620702", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=620702", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "71127", "url": "https://www.rhea-db.org/rhea/71127", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "71131", "url": "https://www.rhea-db.org/rhea/71131", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "71135", "url": "https://www.rhea-db.org/rhea/71135", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "71159", "url": "https://www.rhea-db.org/rhea/71159", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "71163", "url": "https://www.rhea-db.org/rhea/71163", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "71167", "url": "https://www.rhea-db.org/rhea/71167", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "71171", "url": "https://www.rhea-db.org/rhea/71171", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A0H2UHW1", "url": "https://www.uniprot.org/uniprot/A0A0H2UHW1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0H2UHW1-1", "url": "https://www.uniprot.org/uniprot/A0A0H2UHW1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A2VCW5", "url": "https://www.uniprot.org/uniprot/A2VCW5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A2VCW5-1", "url": "https://www.uniprot.org/uniprot/A2VCW5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A2VCW5-2", "url": "https://www.uniprot.org/uniprot/A2VCW5-2", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAISCAVGMEMQEPKMNGTLSTGAAAGYRQEREGFLPTTHGPAPGRKPVQFLDFEGKTSFGMSVFNLSNAIMGSGILGLAYAMAHTGVIFFLALLLCIALLSSYSIHLLLTCASVVGIRAYEQLGQRAFGPAGKVVVAIIICLHNVGAMSSYLFIIKSELPLVIGTFLHMDPEGDWFLKGNLLIILVSLLIILPLALMKHLGYLGYTSSLSLTCMLFFLISVIYKKFQLGCVVSHNDTVVESEPAPLQAFNSSCEAKLFTVDSQMSYTVPIMAFAFVCHPEVLPIYTELCCPTQRRMQAVANMSIGAMFIMYGLTATFGYLTFYSTVKAEMLEMYTQEDLLILCVRLAVLLAVTLTVPVVLFPIRRALQQLLFPSKAFSWPRHVAIALILLILVNILVICVPTIRDIFGFIGSTSAPSLIFILPSVFYLRIVPADMEPLFSWPKIQALCFGVLGVLFMAISLGFMFANWATGQSRMSGH", "length": 479, "header": "sp|A2VCW5-1|S38A5_RAT Isoform 1 of Sodium-coupled neutral amino acid transporter 5 OS=Rattus norvegicus OX=10116 GN=Slc38a5 PE=1 SV=1 CANONICAL=A2VCW5-1" }, "isoforms": [ { "isoform_ac": "A0A0H2UHW1-1", "url": "https://www.uniprot.org/uniprotkb/A2VCW5/entry#A0A0H2UHW1-1", "sequence": { "sequence": "MAISGAVGMEMQEPKMNGTLSTGAAAGYRQEREGFLPTTHGPAPGRKPVQFLDFEGKTSFGMSVFNLSNAIMGSGILGLAYAMAHTGVIFFLALLLCIALLSSYSIHLLLTCASVVGIRAYEQLGQRAFGPAGKVVVAIIICLHNVGAMSSYLFIIKSELPLVIGTFLHMDPEGDWFLKGNLLIILVSLLIILPLALMKHLGYLGYTSSLSLTCMLFFLISVIYKKFQLGCVVSHNDTVVESEPAPLQAFNSSCEAKLFTVDSQMSYTVPIMAFAFVCHPEVLPIYTELCCPTQRRMQAVANMSIGAMFIMYGLTATFGYLTFYSTVKAEMLEMYTQEDLLILCVRLAVLLAVTLTVPVVLFPIRRALQQLLFPSKAFSWPRHVAIALILLILVNILVICVPTIRDIFGFIGSTSAPSLIFILPSVFYLRIVPADMEPLFSWPKIQALCFGVLGVLFMAISLGFMFANWATGQSRMSGH", "length": 479, "header": "tr|A0A0H2UHW1-1|S38A5_RAT Computationally mapped isoform of Sodium-coupled neutral amino acid transporter 5 OS=Rattus norvegicus OX=10116 GN=Slc38a5 PE=1 SV=1 CANONICAL=A2VCW5-1" }, "locus": { "chromosome": "X", "start_pos": 14222181, "end_pos": 14214056, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000038068", "url": "https://www.ensembl.org/id/ENSRNOT00000038068" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000038781", "url": "https://www.ensembl.org/id/ENSRNOP00000038781" } ] } }, { "isoform_ac": "A2VCW5-1", "url": "https://www.uniprot.org/uniprotkb/A2VCW5/entry#A2VCW5-1", "sequence": { "sequence": "MAISCAVGMEMQEPKMNGTLSTGAAAGYRQEREGFLPTTHGPAPGRKPVQFLDFEGKTSFGMSVFNLSNAIMGSGILGLAYAMAHTGVIFFLALLLCIALLSSYSIHLLLTCASVVGIRAYEQLGQRAFGPAGKVVVAIIICLHNVGAMSSYLFIIKSELPLVIGTFLHMDPEGDWFLKGNLLIILVSLLIILPLALMKHLGYLGYTSSLSLTCMLFFLISVIYKKFQLGCVVSHNDTVVESEPAPLQAFNSSCEAKLFTVDSQMSYTVPIMAFAFVCHPEVLPIYTELCCPTQRRMQAVANMSIGAMFIMYGLTATFGYLTFYSTVKAEMLEMYTQEDLLILCVRLAVLLAVTLTVPVVLFPIRRALQQLLFPSKAFSWPRHVAIALILLILVNILVICVPTIRDIFGFIGSTSAPSLIFILPSVFYLRIVPADMEPLFSWPKIQALCFGVLGVLFMAISLGFMFANWATGQSRMSGH", "length": 479, "header": "sp|A2VCW5-1|S38A5_RAT Isoform 1 of Sodium-coupled neutral amino acid transporter 5 OS=Rattus norvegicus OX=10116 GN=Slc38a5 PE=1 SV=1 CANONICAL=A2VCW5-1" }, "locus": {} }, { "isoform_ac": "A2VCW5-2", "url": "https://www.uniprot.org/uniprotkb/A2VCW5/entry#A2VCW5-2", "sequence": { "sequence": "MEMQEPKMNGTLSTGAAAGYRQEREGFLPTTHGPAPGRKPVQFLDFEGKTSFGMSVFNLSNAIMGSGILGLAYAMAHTGVIFFLALLLCIALLSSYSIHLLLTCASVVGIRAYEQLGQRAFGPAGKVVVAIIICLHNVGAMSSYLFIIKSELPLVIGTFLHMDPEGDWFLKGNLLIILVSLLIILPLALMKHLGYLGYTSSLSLTCMLFFLISVIYKKFQLGCVVSHNDTVVESEPAPLQAFNSSCEAKLFTVDSQMSYTVPIMAFAFVCHPEVLPIYTELCCPTQRRMQAVANMSIGAMFIMYGLTATFGYLTFYSTVKAEMLEMYTQEDLLILCVRLAVLLAVTLTVPVVLFPIRRALQQLLFPSKAFSWPRHVAIALILLILVNILVICVPTIRDIFGFIGSTSAPSLIFILPSVFYLRIVPADMEPLFSWPKIQALCFGVLGVLFMAISLGFMFANWATGQSRMSGH", "length": 471, "header": "sp|A2VCW5-2|S38A5_RAT Isoform 2 of Sodium-coupled neutral amino acid transporter 5 OS=Rattus norvegicus OX=10116 GN=Slc38a5 PE=1 SV=1 CANONICAL=A2VCW5-1" }, "locus": { "chromosome": "X", "start_pos": 14221809, "end_pos": 14214056, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000079664.2", "url": "https://www.ensembl.org/id/ENSRNOT00000079664.2" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000073818.1", "url": "https://www.ensembl.org/id/ENSRNOP00000073818.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 236, "start_aa": "Asn", "end_pos": 236, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn236", "evidence": [ { "id": "A2VCW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2VCW5#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Cloning and functional characterization of a new subtype of the amino acid transport system N.", "journal": "American journal of physiology. Cell physiology", "date": "2001", "authors": "Nakanishi T, Kekuda R, Fei YJ, Hatanaka T, Sugawara M, Martindale RG, Leibach FH, Prasad PD, Ganapathy V", "evidence": [ { "database": "UniProtKB", "id": "A2VCW5", "url": "https://www.uniprot.org/uniprot/A2VCW5" } ], "reference": [ { "type": "PubMed", "id": "11698233", "url": "https://glygen.org/publication/PubMed/11698233" } ] }, { "title": "Bidirectional substrate fluxes through the system N (SNAT5) glutamine transporter may determine net glutamine flux in rat liver.", "journal": "The Journal of physiology", "date": "2004-09-01", "authors": "Baird F E, Beattie K J, Hyde A R, Ganapathy V, Rennie M J, Taylor P M", "evidence": [ { "database": "UniProtKB", "id": "A2VCW5", "url": "https://www.uniprot.org/uniprot/A2VCW5" } ], "reference": [ { "type": "PubMed", "id": "15218073", "url": "https://glygen.org/publication/PubMed/15218073" } ] }, { "title": "Amino acid transporter SNAT5 localizes to glial cells in the rat brain.", "journal": "Glia", "date": "2005", "authors": "Cubelos B, Gonzalez-Gonzalez IM, Gimenez C, Zafra F", "evidence": [ { "database": "UniProtKB", "id": "A2VCW5", "url": "https://www.uniprot.org/uniprot/A2VCW5" }, { "database": "RefSeq", "id": "NP_620209", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620209" } ], "reference": [ { "type": "PubMed", "id": "15390093", "url": "https://glygen.org/publication/PubMed/15390093" } ] }, { "title": "Expression and function of glutamine transporters SN1 (SNAT3) and SN2 (SNAT5) in retinal M\u00fcller cells.", "journal": "Investigative ophthalmology & visual science", "date": "2005-11", "authors": "Umapathy Nagavedi S, Li Weiguo, Mysona Barbara A, Smith Sylvia B, Ganapathy Vadivel", "evidence": [ { "database": "UniProtKB", "id": "A2VCW5", "url": "https://www.uniprot.org/uniprot/A2VCW5" } ], "reference": [ { "type": "PubMed", "id": "16249471", "url": "https://glygen.org/publication/PubMed/16249471" } ] }, { "title": "Evidence for allosteric regulation of pH-sensitive System A (SNAT2) and System N (SNAT5) amino acid transporter activity involving a conserved histidine residue.", "journal": "The Biochemical journal", "date": "2006", "authors": "Baird FE, Pinilla-Tenas JJ, Ogilvie WL, Ganapathy V, Hundal HS, Taylor PM", "evidence": [ { "database": "UniProtKB", "id": "A2VCW5", "url": "https://www.uniprot.org/uniprot/A2VCW5" }, { "database": "RefSeq", "id": "NP_620209", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620209" } ], "reference": [ { "type": "PubMed", "id": "16629640", "url": "https://glygen.org/publication/PubMed/16629640" } ] }, { "title": "Changes of plasma glutamine concentration and hepatocyte membrane system N transporters expression in early endotoxemia.", "journal": "The Journal of surgical research", "date": "2011", "authors": "Wang W, Li Y, Zhang W, Zhang F, Li J", "evidence": [ { "database": "RefSeq", "id": "NP_620209", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620209" } ], "reference": [ { "type": "PubMed", "id": "20036385", "url": "https://glygen.org/publication/PubMed/20036385" } ] }, { "title": "The system N transporter SN2 doubles as a transmitter precursor furnisher and a potential regulator of NMDA receptors.", "journal": "Glia", "date": "2012", "authors": "Hamdani el H, Gudbrandsen M, Bjorkmo M, Chaudhry FA", "evidence": [ { "database": "UniProtKB", "id": "A2VCW5", "url": "https://www.uniprot.org/uniprot/A2VCW5" }, { "database": "RefSeq", "id": "NP_620209", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620209" } ], "reference": [ { "type": "PubMed", "id": "22821889", "url": "https://glygen.org/publication/PubMed/22821889" } ] }, { "title": "Expression of the System N transporter (SNAT5/SN2) during development indicates its plausible role in glutamatergic neurotransmission.", "journal": "Neurochem. Int.", "date": "2014", "authors": "Rodriguez A, Ortega A, Berumen LC, Garcia-Alcocer MG, Gimenez C, Zafra F", "evidence": [ { "database": "UniProtKB", "id": "A2VCW5", "url": "https://www.uniprot.org/uniprot/A2VCW5" }, { "database": "RefSeq", "id": "NP_620209", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620209" } ], "reference": [ { "type": "PubMed", "id": "24333324", "url": "https://glygen.org/publication/PubMed/24333324" } ] } ], "pathway": [ { "id": "rno:192208", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:192208", "resource": "KEGG Pathway" }, { "id": "R-RNO-352230", "name": "Amino acid transport across the plasma membrane", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-352230", "resource": "Reactome", "description": "Amino acid transport across the plasma membrane" } ], "orthologs": [ { "uniprot_canonical_ac": "Q3U1J0-1", "protein_name": "Sodium-coupled neutral amino acid transporter 5", "gene_name": "Slc38a5", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAISCAVGMEMQEPKMNGTLSAGAAAGYRQEREGFLPTTRNPATGRKPVQFLDFEGKTSFGMSVFNLSNAIMGSGILGLAYAMAHTGVIFFLALLLCIALLSSYSIHLLLTCASVVGIRAYEQLGQRAFGPAGKVVVAIIICLHNVGAMSSYLFIIKSELPLVIGTFLHMDPEGDWFLKGNLLIILVSLLIILPLALMKHLGYLGYTSSLSLTCMLFFLISVIYKKFQIGCDVSHNDTVVEAEQAPLQAFNSSCEAELFTVDSQMSYTVPIMAFAFVCHPEVLPIYTELCRPTQRRMQAVANMSIGAMFIMYGLTATFGYLTFYSTVKAEMLEMYTQEDMLILCVRLAVLLAVTLTVPVVLFPIRRALQQLLFPSKAFSWLRHVAIALILLILVNILVICVPTIRDIFGFIGSTSAPSLIFILPSVFYLRIVPTEVEPLFSWPKIQALCFGVLGVLFMAISLGFMFANWATGQSRMSGH", "length": 479 }, "evidence": [ { "id": "46363504", "url": "http://www.informatics.jax.org/homology/46363504", "database": "MGI" }, { "id": "A2VCW5", "url": "https://omabrowser.org/oma/group/A2VCW5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8WUX1-1", "protein_name": "Sodium-coupled neutral amino acid transporter 5", "gene_name": "SLC38A5", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MELQDPKMNGALPSDAVGYRQEREGFLPSRGPAPGSKPVQFMDFEGKTSFGMSVFNLSNAIMGSGILGLAYAMAHTGVIFFLALLLCIALLSSYSIHLLLTCAGIAGIRAYEQLGQRAFGPAGKVVVATVICLHNVGAMSSYLFIIKSELPLVIGTFLYMDPEGDWFLKGNLLIIIVSVLIILPLALMKHLGYLGYTSGLSLTCMLFFLVSVIYKKFQLGCAIGHNETAMESEALVGLPSQGLNSSCEAQMFTVDSQMSYTVPIMAFAFVCHPEVLPIYTELCRPSKRRMQAVANVSIGAMFCMYGLTATFGYLTFYSSVKAEMLHMYSQKDPLILCVRLAVLLAVTLTVPVVLFPIRRALQQLLFPGKAFSWPRHVAIALILLVLVNVLVICVPTIRDIFGVIGSTSAPSLIFILPSIFYLRIVPSEVEPFLSWPKIQALCFGVLGVLFMAVSLGFMFANWATGQSRMSGH", "length": 472 }, "evidence": [ { "id": "46363504", "url": "http://www.informatics.jax.org/homology/46363504", "database": "MGI" }, { "id": "A2VCW5", "url": "https://omabrowser.org/oma/group/A2VCW5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A2VCW5", "url": "https://www.uniprot.org/uniprot/A2VCW5" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A2VCW5", "url": "https://www.uniprot.org/uniprot/A2VCW5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 12, "go_terms": [ { "name": "L-glutamine import across plasma membrane", "id": "GO:1903803", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903803", "evidence": [ { "database": "UniProtKB", "id": "A2VCW5", "url": "https://www.uniprot.org/uniprot/A2VCW5" } ], "pmid": "" }, { "name": "glycine transport", "id": "GO:0015816", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015816", "evidence": [ { "database": "UniProtKB", "id": "A2VCW5", "url": "https://www.uniprot.org/uniprot/A2VCW5" } ], "pmid": "" }, { "name": "serine transport", "id": "GO:0032329", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032329", "evidence": [ { "database": "UniProtKB", "id": "A2VCW5", "url": "https://www.uniprot.org/uniprot/A2VCW5" } ], "pmid": "" }, { "name": "asparagine transmembrane transport", "id": "GO:1903713", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903713", "evidence": [ { "database": "UniProtKB", "id": "A2VCW5", "url": "https://www.uniprot.org/uniprot/A2VCW5" } ], "pmid": "" }, { "name": "L-alanine transmembrane transport", "id": "GO:1904557", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904557", "evidence": [ { "database": "UniProtKB", "id": "A2VCW5", "url": "https://www.uniprot.org/uniprot/A2VCW5" } ], "pmid": "" }, { "name": "L-serine transport", "id": "GO:0015825", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015825", "evidence": [ { "database": "UniProtKB", "id": "A2VCW5", "url": "https://www.uniprot.org/uniprot/A2VCW5" } ], "pmid": "" }, { "name": "glutamine transport", "id": "GO:0006868", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006868", "evidence": [ { "database": "UniProtKB", "id": "A2VCW5", "url": "https://www.uniprot.org/uniprot/A2VCW5" } ], "pmid": "" }, { "name": "neutral amino acid transport", "id": "GO:0015804", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015804", "evidence": [ { "database": "UniProtKB", "id": "A2VCW5", "url": "https://www.uniprot.org/uniprot/A2VCW5" } ], "pmid": "" }, { "name": "L-histidine transmembrane transport", "id": "GO:0089709", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0089709", "evidence": [ { "database": "UniProtKB", "id": "A2VCW5", "url": "https://www.uniprot.org/uniprot/A2VCW5" } ], "pmid": "" }, { "name": "amino acid export across plasma membrane", "id": "GO:0032973", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032973", "evidence": [ { "database": "UniProtKB", "id": "A2VCW5", "url": "https://www.uniprot.org/uniprot/A2VCW5" } ], "pmid": "" }, { "name": "amino acid import across plasma membrane", "id": "GO:0089718", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0089718", "evidence": [ { "database": "UniProtKB", "id": "A2VCW5", "url": "https://www.uniprot.org/uniprot/A2VCW5" } ], "pmid": "" }, { "name": "L-serine import across plasma membrane", "id": "GO:1903812", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903812", "evidence": [ { "database": "UniProtKB", "id": "A2VCW5", "url": "https://www.uniprot.org/uniprot/A2VCW5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 10, "go_terms": [ { "name": "L-glutamine, sodium:proton antiporter activity", "id": "GO:0140830", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140830", "evidence": [ { "database": "UniProtKB", "id": "A2VCW5", "url": "https://www.uniprot.org/uniprot/A2VCW5" } ], "pmid": "" }, { "name": "glycine transmembrane transporter activity", "id": "GO:0015187", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015187", "evidence": [ { "database": "UniProtKB", "id": "A2VCW5", "url": "https://www.uniprot.org/uniprot/A2VCW5" } ], "pmid": "" }, { "name": "amino acid transmembrane transporter activity", "id": "GO:0015171", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015171", "evidence": [ { "database": "UniProtKB", "id": "A2VCW5", "url": "https://www.uniprot.org/uniprot/A2VCW5" } ], "pmid": "" }, { "name": "neutral L-amino acid transmembrane transporter activity", "id": "GO:0015175", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015175", "evidence": [ { "database": "UniProtKB", "id": "A2VCW5", "url": "https://www.uniprot.org/uniprot/A2VCW5" } ], "pmid": "" }, { "name": "L-glutamine transmembrane transporter activity", "id": "GO:0015186", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015186", "evidence": [ { "database": "UniProtKB", "id": "A2VCW5", "url": "https://www.uniprot.org/uniprot/A2VCW5" } ], "pmid": "" }, { "name": "L-serine transmembrane transporter activity", "id": "GO:0015194", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015194", "evidence": [ { "database": "UniProtKB", "id": "A2VCW5", "url": "https://www.uniprot.org/uniprot/A2VCW5" } ], "pmid": "" }, { "name": "L-histidine transmembrane 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