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dominant 33" } ], "evidence": [ { "id": "0070063", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0070063" } ] }, { "disease_id": "DOID:0080642", "recommended_name": { "id": "DOID:0080642", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0080642", "name": "Middle East respiratory syndrome", "description": "A Coronavirus infectious disease that is characterized by severe respiratory illness, including fever, cough, and shortness of breath and that has_material_basis_in MERS-CoV." }, "synonyms": [], "evidence": [ { "id": "0080642", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0080642" } ] }, { "disease_id": "DOID:12377", "recommended_name": { "id": "DOID:12377", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:12377", "name": "spinal muscular atrophy", "description": "A motor neuron disease that is a degenerative neuromuscular disease characterized by lower motor neuron degeneration associated with progressive muscle weakness and atrophy." }, "synonyms": [], "evidence": [ { "id": "12377", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:12377" } ] }, { "disease_id": "DOID:332", "recommended_name": { "id": "DOID:332", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:332", "name": "amyotrophic lateral sclerosis", "description": "A motor neuron disease that is characterized by muscle spasticity, rapidly progressive weakness due to muscle atrophy, difficulty in speaking, swallowing, and breathing." }, "synonyms": [ { "id": "DOID:332", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:332", "name": "ALS", "description": "" }, { "id": "DOID:332", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:332", "name": "Lou Gehrig's disease", "description": "" }, { "id": "DOID:332", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:332", "name": "motor neuron disease, bulbar", "description": "" }, { "id": "MONDO:0007103", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007103", "name": "amyotrophic lateral sclerosis type 1", "description": "" }, { "id": "MONDO:0007103", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007103", "name": "ALS1", "description": "" }, { "id": "MONDO:0007103", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007103", "name": "amyotrophic lateral sclerosis 1", "description": "" }, { "id": "MONDO:0007103", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007103", "name": "amyotrophic lateral sclerosis type 1", "description": "" }, { "id": "MONDO:0007103", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007103", "name": "FALS", "description": "" }, { "id": "MONDO:0007103", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007103", "name": "amyotrophic lateral sclerosis 1, autosomal dominant", "description": "" }, { "id": "MONDO:0007103", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007103", "name": "amyotrophic lateral sclerosis 1, autosomal dominant amyotrophic lateral sclerosis 1, autosomal recessive, included", "description": "" }, { "id": "MONDO:0007103", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007103", "name": "amyotrophic lateral sclerosis 1, autosomal recessive", "description": "" }, { "id": "MONDO:0007103", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007103", "name": "amyotrophic lateral sclerosis 1, familial", "description": "" }, { "id": "MONDO:0007103", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007103", "name": "amyotrophic lateral sclerosis, autosomal dominant", "description": "" }, { "id": "MONDO:0007103", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007103", "name": "amyotrophic lateral sclerosis, familial", "description": "" }, { "id": "MONDO:0007103", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007103", "name": "amyotrophic lateral sclerosis, sporadic", "description": "" }, { "id": "MONDO:0007103", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007103", "name": "amyotrophic lateral sclerosis, sporadic, included", "description": "" }, { "id": "MONDO:0007103", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007103", "name": "amyotrophic lateral sclerosis, susceptibility to", "description": "" }, { "id": "MIM:105400", "resource": "MIM", "url": "https://www.omim.org/entry/105400", "name": "Amyotrophic lateral sclerosis 1", "description": "Amyotrophic lateral sclerosis 1" } ], "evidence": [ { "id": "332", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:332" } ] }, { "disease_id": "DOID:3748", "recommended_name": { "id": "DOID:3748", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3748", "name": "esophagus squamous cell carcinoma", "description": "An esophageal carcinoma that derives_from epithelial squamous cells located_in the esophagus." }, "synonyms": [ { "id": "DOID:3748", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3748", "name": "SCC of esophagus", "description": "" }, { "id": "DOID:3748", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3748", "name": "SCC of oesophagus", "description": "" }, { "id": "DOID:3748", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3748", "name": "oesophagus squamous cell carcinoma", "description": "" } ], "evidence": [ { "id": "3748", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:3748" } ] }, { "disease_id": "DOID:3907", "recommended_name": { "id": "DOID:3907", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3907", "name": "lung squamous cell carcinoma", "description": "A non-small cell lung carcinoma that has_material_basis_in the squamous cell." }, "synonyms": [ { "id": "DOID:3907", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3907", "name": "Epidermoid cell carcinoma of the lung", "description": "" } ], "evidence": [ { "id": "3907", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:3907" } ] }, { "disease_id": "DOID:3908", "recommended_name": { "id": "DOID:3908", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3908", "name": "lung non-small cell carcinoma", "description": "A lung carcinoma that is characterized as any type of epithelial lung cancer other than small cell lung 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"MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes mellitus, type 2, protection against", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes mellitus, type 2, susceptibility to", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes mellitus, type II, susceptibility to", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "hypertension, insulin resistance-related, susceptibility to", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "insulin resistance, susceptibility to", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "maturity-onset diabetes", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "type 2 diabetes mellitus, susceptibility to", "description": "" }, { "id": "MONDO:0011027", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011027", "name": "diabetes mellitus, noninsulin-dependent, 1", "description": "" }, { "id": "MONDO:0011027", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011027", "name": "diabetes mellitus, noninsulin-dependent 1", "description": "" }, { "id": "MONDO:0011027", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011027", "name": "diabetes mellitus, noninsulin-dependent, 1", "description": "" }, { "id": "MONDO:0011027", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011027", "name": "diabetes mellitus, noninsulin-dependent, type 1", "description": "" }, { "id": "MONDO:0011027", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011027", "name": "NIDDM1", "description": "" }, { "id": "MONDO:0011027", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011027", "name": "noninsulin-dependent diabetes mellitus 1", "description": "" }, { "id": "MONDO:0011072", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011072", "name": "diabetes mellitus, noninsulin-dependent, 2", "description": "" }, { "id": "MONDO:0011072", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011072", "name": "NIDDM2", "description": "" }, { "id": "MONDO:0011072", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011072", "name": "diabetes mellitus, noninsulin-dependent, 2", "description": "" }, { "id": "MONDO:0011072", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011072", "name": "noninsulin-dependent diabetes mellitus 2", "description": "" }, { "id": "MONDO:0011363", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011363", "name": "diabetes mellitus, noninsulin-dependent, 3", "description": "" }, { "id": "MONDO:0011363", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011363", "name": "diabetes mellitus, noninsulin-dependent, 3", "description": "" }, { "id": "MONDO:0011363", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011363", "name": "diabetes mellitus, noninsulin-dependent, type 3", "description": "" }, { "id": "MONDO:0011363", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011363", "name": "type 2 diabetes mellitus 3", "description": "" }, { "id": "MONDO:0011363", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011363", "name": "NIDDM3", "description": "" }, { "id": "MONDO:0011363", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011363", "name": "noninsulin-dependent diabetes mellitus 3", "description": "" }, { "id": "MIM:125853", "resource": "MIM", "url": "https://www.omim.org/entry/125853", "name": "Type 2 diabetes mellitus", "description": "Type 2 diabetes mellitus" }, { "id": "MIM:601283", "resource": "MIM", "url": "https://www.omim.org/entry/601283", "name": "Type 2 diabetes mellitus 1", "description": "Type 2 diabetes mellitus 1" } ], "evidence": [ { "id": "9352", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:9352" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "A2RVG6", "url": "https://www.uniprot.org/uniprot/A2RVG6" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "gene": [ { "name": "ome", "url": "https://www.uniprot.org/uniprot/A2RVG6", "locus": { "chromosome": "3L", "start_pos": 14747868, "end_pos": 14672839, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "FBgn0259175", "url": "https://www.ensembl.org/id/FBgn0259175" } ] } } ], "crossref": [ { "id": "FBgn0259175", "url": "https://bgee.org/?page=gene&gene_id=FBgn0259175", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "FBgn0259175", "url": "https://flybase.org/reports/FBgn0259175", "database": "FlyBase", "categories": [ "Organism-specific" ] }, { "id": "44297", "url": "https://www.ncbi.nlm.nih.gov/gene/44297", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "Q9VUH1", "url": "https://www.ebi.ac.uk/intact/interactors/id:Q9VUH1*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR001375", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001375", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002469", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002469", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029058", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029058", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "dme:Dmel_CG42280", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+dme:Dmel_CG42280", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "MRTPQEN", "url": "https://omabrowser.org/oma/group/MRTPQEN/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "2876738at2759", "url": "http://www.orthodb.org/?query=2876738at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11731", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11731", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11731:SF192", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11731:SF192", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00326", "url": "http://pfam.xfam.org/family/PF00326", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF00930", "url": "http://pfam.xfam.org/family/PF00930", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "NP_001097606", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001097606", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A2RVG6", "url": "https://www.uniprot.org/uniprot/A2RVG6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A2RVG6-1", "url": "https://www.uniprot.org/uniprot/A2RVG6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "M9PCH6", "url": "https://www.uniprot.org/uniprot/M9PCH6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "M9PCH6-1", "url": "https://www.uniprot.org/uniprot/M9PCH6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q29R16", "url": "https://www.uniprot.org/uniprot/Q29R16", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q29R16-1", "url": "https://www.uniprot.org/uniprot/Q29R16-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9VUH1", "url": "https://www.uniprot.org/uniprot/Q9VUH1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9VUH1-1", "url": "https://www.uniprot.org/uniprot/Q9VUH1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSGNDVSVTETAQSDQFHLPTTANAAAHHQYYRFHKQQQQQHQHHHQQQQSCLRQQQRQLQWEQQQHQQLQHQLTNSSSEFDEFHWPSKQTGGENLGGKIYITPADIPPPPQPPHQSGSNSHSHHNGSNRQQQQHQQHPHSLHSHIHPHPHPHHQHGHRTPPHRCKCEHPSIELMGYEDSVIATATASNTAANVGVAGGGGVGRHQHPPYYYKAAVGRRSSAKLHESMLGGGSSLEDDDGTSAGSFGEGMSRFKNLMHTKEKKRRVRIILTVVTTVIAVALLATALVFILRTDEKDADDSDSNSNNAIDLEDVLSGQLYAKRFNGSWSNGNSLIYKENTSIMEFDAKTGERSILLEDAQHYVLYEKSADGEFLLLAKNYKKNFRYSFLAEYDLYNLNTKEFIQLTIQNEQHYLSMVQWSPVGNALVINYDRNLYYKESALAQEIALTSDEQAGILNGIPDWVYEEEVFSSNVATWFNPSGTQLAFIKFDDSSTHLINFPYYGDAGDLRYQYPLHQVIAYPKAGSSNPRVELVMVDLKRAVAGGDFVTVMPVPSALNTETDYIVTVVSWVDDDNVLSIWMNRIQNAAYVVTFDGLNRKVIYSAESKTGWVDLYTAPFRNRNGSRLAFVLPHNNYKHVQLLSSTVASSEPQALEPLTEGKYVVDSILHWDGKNDIIFYTANTEDHPEQLHLYAIRALAKQSPKCLTCNLIKSGDVQQTYFSATFNDNNHIVITSLGPGIPTTHIYEWKYENSQVVISKVLDWETNESLRAKLKGVALPSHKILTVDIDGGFQAKVLLQLPPNLDTSGATKYPMLVDVYGGPDSYSVTNKWMVDWGTYLSSNQSVIYAKIDGRGSGLRGESLLHAIYLKLGTVEISDQINVTQKLSTLFNYIDPDHVGIWGWSYGGYAAAMALANDEAKVFKCAASIAPVTDWAYYDSIYTERYMGLPNTNELGYANSRLSTMAVKLRGKKYLLVHGTLDDNVHYQQAMILAKNLERQDILFKQISYADEDHGLSNVRPHLYHSLDRFFGECFASSRLMKSAK", "length": 1040, "header": "tr|A2RVG6-1|A2RVG6_DROME Isoform 1 of IP17501p OS=Drosophila melanogaster OX=7227 GN=ome PE=1 SV=1 CANONICAL=A2RVG6-1" }, "isoforms": [ { "isoform_ac": "A2RVG6-1", "url": "https://www.uniprot.org/uniprotkb/A2RVG6/entry#A2RVG6-1", "sequence": { "sequence": "MSGNDVSVTETAQSDQFHLPTTANAAAHHQYYRFHKQQQQQHQHHHQQQQSCLRQQQRQLQWEQQQHQQLQHQLTNSSSEFDEFHWPSKQTGGENLGGKIYITPADIPPPPQPPHQSGSNSHSHHNGSNRQQQQHQQHPHSLHSHIHPHPHPHHQHGHRTPPHRCKCEHPSIELMGYEDSVIATATASNTAANVGVAGGGGVGRHQHPPYYYKAAVGRRSSAKLHESMLGGGSSLEDDDGTSAGSFGEGMSRFKNLMHTKEKKRRVRIILTVVTTVIAVALLATALVFILRTDEKDADDSDSNSNNAIDLEDVLSGQLYAKRFNGSWSNGNSLIYKENTSIMEFDAKTGERSILLEDAQHYVLYEKSADGEFLLLAKNYKKNFRYSFLAEYDLYNLNTKEFIQLTIQNEQHYLSMVQWSPVGNALVINYDRNLYYKESALAQEIALTSDEQAGILNGIPDWVYEEEVFSSNVATWFNPSGTQLAFIKFDDSSTHLINFPYYGDAGDLRYQYPLHQVIAYPKAGSSNPRVELVMVDLKRAVAGGDFVTVMPVPSALNTETDYIVTVVSWVDDDNVLSIWMNRIQNAAYVVTFDGLNRKVIYSAESKTGWVDLYTAPFRNRNGSRLAFVLPHNNYKHVQLLSSTVASSEPQALEPLTEGKYVVDSILHWDGKNDIIFYTANTEDHPEQLHLYAIRALAKQSPKCLTCNLIKSGDVQQTYFSATFNDNNHIVITSLGPGIPTTHIYEWKYENSQVVISKVLDWETNESLRAKLKGVALPSHKILTVDIDGGFQAKVLLQLPPNLDTSGATKYPMLVDVYGGPDSYSVTNKWMVDWGTYLSSNQSVIYAKIDGRGSGLRGESLLHAIYLKLGTVEISDQINVTQKLSTLFNYIDPDHVGIWGWSYGGYAAAMALANDEAKVFKCAASIAPVTDWAYYDSIYTERYMGLPNTNELGYANSRLSTMAVKLRGKKYLLVHGTLDDNVHYQQAMILAKNLERQDILFKQISYADEDHGLSNVRPHLYHSLDRFFGECFASSRLMKSAK", "length": 1040, "header": "tr|A2RVG6-1|A2RVG6_DROME Isoform 1 of IP17501p OS=Drosophila melanogaster OX=7227 GN=ome PE=1 SV=1 CANONICAL=A2RVG6-1" }, "locus": { "chromosome": "3L", "start_pos": 14747091, "end_pos": 14736088, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "FBtr0299651", "url": "https://www.ensembl.org/id/FBtr0299651" }, { "database": "Ensembl Peptide", "id": "FBpp0288926", "url": "https://www.ensembl.org/id/FBpp0288926" } ] } }, { "isoform_ac": "M9PCH6-1", "url": "https://www.uniprot.org/uniprotkb/A2RVG6/entry#M9PCH6-1", "sequence": { "sequence": "MHTKEKKRRVRIILTVVTTVIAVALLATALVFILRTDEKDADDSDSNSNNAIDLEDVLSGQLYAKRFNGSWSNGNSLIYKENTSIMEFDAKTGERSILLEDAQHYVLYEKSADGEFLLLAKNYKKNFRYSFLAEYDLYNLNTKEFIQLTIQNEQHYLSMVQWSPVGNALVINYDRNLYYKESALAQEIALTSDEQAGILNGIPDWVYEEEVFSSNVATWFNPSGTQLAFIKFDDSSTHLINFPYYGDAGDLRYQYPLHQVIAYPKAGSSNPRVELVMVDLKRAVAGGDFVTVMPVPSALNTETDYIVTVVSWVDDDNVLSIWMNRIQNAAYVVTFDGLNRKVIYSAESKTGWVDLYTAPFRNRNGSRLAFVLPHNNYKHVQLLSSTVASSEPQALEPLTEGKYVVDSILHWDGKNDIIFYTANTEDHPEQLHLYAIRALAKQSPKCLTCNLIKSGDVQQTYFSATFNDNNHIVITSLGPGIPTTHIYEWKYENSQVVISKVLDWETNESLRAKLKGVALPSHKILTVDIDGGFQAKVLLQLPPNLDTSGATKYPMLVDVYGGPDSYSVTNKWMVDWGTYLSSNQSVIYAKIDGRGSGLRGESLLHAIYLKLGTVEISDQINVTQKLSTLFNYIDPDHVGIWGWSYGGYAAAMALANDEAKVFKCAASIAPVTDWAYYDSIYTERYMGLPNTNELGYANSRLSTMAVKLRGKKYLLVHGTLDDNVHYQQAMILAKNLERQDILFKQISYADEDHGLSNVRPHLYHSLDRFFGECFASSRLMKSAK", "length": 784, "header": "tr|M9PCH6-1|A2RVG6_DROME Computationally mapped isoform of IP17501p OS=Drosophila melanogaster OX=7227 GN=ome PE=1 SV=1 CANONICAL=A2RVG6-1" }, "locus": { "chromosome": "3L", "start_pos": 14747091, "end_pos": 14744195, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "FBtr0333043", "url": "https://www.ensembl.org/id/FBtr0333043" }, { "database": "Ensembl Peptide", "id": "FBpp0305257", "url": "https://www.ensembl.org/id/FBpp0305257" } ] } }, { "isoform_ac": "Q29R16-1", "url": "https://www.uniprot.org/uniprotkb/A2RVG6/entry#Q29R16-1", "sequence": { "sequence": "MSAAGWLDMNAALQNLDSPPETVKKARTKRRSSYAGRTTATAGVHGRGSIGTISSGIIKSFRERFLSNSSGDSGKYRKLRQRDAESGRMEASGSSSSGENEDPSSSSSVEDLFANEAERRNWHRKTSEKRRRNARKKNLMHTKEKKRRVRIILTVVTTVIAVALLATALVFILRTDEKDADDSDSNSNNAIDLEDVLSGQLYAKRFNGSWSNGNSLIYKENTSIMEFDAKTGERSILLEDAQHYVLYEKSADGEFLLLAKNYKKNFRYSFLAEYDLYNLNTKEFIQLTIQNEQHYLSMVQWSPVGNALVINYDRNLYYKESALAQEIALTSDEQAGILNGIPDWVYEEEVFSSNVATWFNPSGTQLAFIKFDDSSTHLINFPYYGDAGDLRYQYPLHQVIAYPKAGSSNPRVELVMVDLKRAVAGGDFVTVMPVPSALNTETDYIVTVVSWVDDDNVLSIWMNRIQNAAYVVTFDGLNRKVIYSAESKTGWVDLYTAPFRNRNGSRLAFVLPHNNYKHVQLLSSTVASSEPQALEPLTEGKYVVDSILHWDGKNDIIFYTANTEDHPEQLHLYAIRALAKQSPKCLTCNLIKSGDVQQTYFSATFNDNNHIVITSLGPGIPTTHIYEWKYENSQVVISKVLDWETNESLRAKLKGVALPSHKILTVDIDGGFQAKVLLQLPPNLDTSGATKYPMLVDVYGGPDSYSVTNKWMVDWGTYLSSNQSVIYAKIDGRGSGLRGESLLHAIYLKLGTVEISDQINVTQKLSTLFNYIDPDHVGIWGWSYGGYAAAMALANDEAKVFKCAASIAPVTDWAYYDSIYTERYMGLPNTNELGYANSRLSTMAVKLRGKKYLLVHGTLDDNVHYQQAMILAKNLERQDILFKQISYADEDHGLSNVRPHLYHSLDRFFGECFASSRLMKSAK", "length": 923, "header": "tr|Q29R16-1|A2RVG6_DROME Computationally mapped isoform of IP17501p OS=Drosophila melanogaster OX=7227 GN=ome PE=1 SV=1 CANONICAL=A2RVG6-1" }, "locus": { "chromosome": "3L", "start_pos": 14747091, "end_pos": 14680377, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "FBtr0299649", "url": "https://www.ensembl.org/id/FBtr0299649" }, { "database": "Ensembl Peptide", "id": "FBpp0288924", "url": "https://www.ensembl.org/id/FBpp0288924" } ] } }, { "isoform_ac": "Q9VUH1-1", "url": "https://www.uniprot.org/uniprotkb/A2RVG6/entry#Q9VUH1-1", "sequence": { "sequence": "MSGNDVSVTETAQSDQNLMHTKEKKRRVRIILTVVTTVIAVALLATALVFILRTDEKDADDSDSNSNNAIDLEDVLSGQLYAKRFNGSWSNGNSLIYKENTSIMEFDAKTGERSILLEDAQHYVLYEKSADGEFLLLAKNYKKNFRYSFLAEYDLYNLNTKEFIQLTIQNEQHYLSMVQWSPVGNALVINYDRNLYYKESALAQEIALTSDEQAGILNGIPDWVYEEEVFSSNVATWFNPSGTQLAFIKFDDSSTHLINFPYYGDAGDLRYQYPLHQVIAYPKAGSSNPRVELVMVDLKRAVAGGDFVTVMPVPSALNTETDYIVTVVSWVDDDNVLSIWMNRIQNAAYVVTFDGLNRKVIYSAESKTGWVDLYTAPFRNRNGSRLAFVLPHNNYKHVQLLSSTVASSEPQALEPLTEGKYVVDSILHWDGKNDIIFYTANTEDHPEQLHLYAIRALAKQSPKCLTCNLIKSGDVQQTYFSATFNDNNHIVITSLGPGIPTTHIYEWKYENSQVVISKVLDWETNESLRAKLKGVALPSHKILTVDIDGGFQAKVLLQLPPNLDTSGATKYPMLVDVYGGPDSYSVTNKWMVDWGTYLSSNQSVIYAKIDGRGSGLRGESLLHAIYLKLGTVEISDQINVTQKLSTLFNYIDPDHVGIWGWSYGGYAAAMALANDEAKVFKCAASIAPVTDWAYYDSIYTERYMGLPNTNELGYANSRLSTMAVKLRGKKYLLVHGTLDDNVHYQQAMILAKNLERQDILFKQISYADEDHGLSNVRPHLYHSLDRFFGECFASSRLMKSAK", "length": 802, "header": "tr|Q9VUH1-1|A2RVG6_DROME Computationally mapped isoform of IP17501p OS=Drosophila melanogaster OX=7227 GN=ome PE=1 SV=1 CANONICAL=A2RVG6-1" }, "locus": { "chromosome": "3L", "start_pos": 14747091, "end_pos": 14736088, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "FBtr0299650", "url": "https://www.ensembl.org/id/FBtr0299650" }, { "database": "Ensembl Peptide", "id": "FBpp0288925", "url": "https://www.ensembl.org/id/FBpp0288925" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "The genome sequence of Drosophila melanogaster.", "journal": "Science", "date": "2000", "authors": "Adams MD, Celniker SE, Holt RA, Evans CA, Gocayne JD, Amanatides PG, Scherer SE, Li PW, Hoskins RA, Galle RF, George RA, Lewis SE, Richards S, Ashburner M, Henderson SN, Sutton GG, Wortman JR, Yandell MD, Zhang Q, Chen LX, Brandon RC, Rogers YH, Blazej RG, Champe M, Pfeiffer BD, Wan KH, Doyle C, Baxter EG, Helt G, Nelson CR, Gabor GL, Abril JF, Agbayani A, An HJ, Andrews-Pfannkoch C, Baldwin D, Ballew RM, Basu A, Baxendale J, Bayraktaroglu L, Beasley EM, Beeson KY, Benos PV, Berman BP, Bhandari D, Bolshakov S, Borkova D, Botchan MR, Bouck J, Brokstein P, Brottier P, Burtis KC, Busam DA, Butler H, Cadieu E, Center A, Chandra I, Cherry JM, Cawley S, Dahlke C, Davenport LB, Davies P, de Pablos B, Delcher A, Deng Z, Mays AD, Dew I, Dietz SM, Dodson K, Doup LE, Downes M, Dugan-Rocha S, Dunkov BC, Dunn P, Durbin KJ, Evangelista CC, Ferraz C, Ferriera S, Fleischmann W, Fosler C, Gabrielian AE, Garg NS, Gelbart WM, Glasser K, Glodek A, Gong F, Gorrell JH, Gu Z, Guan P, Harris M, Harris NL, Harvey D, Heiman TJ, Hernandez JR, Houck J, Hostin D, Houston KA, Howland TJ, Wei MH, Ibegwam C, Jalali M, Kalush F, Karpen GH, Ke Z, Kennison JA, Ketchum KA, Kimmel BE, Kodira CD, Kraft C, Kravitz S, Kulp D, Lai Z, Lasko P, Lei Y, Levitsky AA, Li J, Li Z, Liang Y, Lin X, Liu X, Mattei B, McIntosh TC, McLeod MP, McPherson D, Merkulov G, Milshina NV, Mobarry C, Morris J, Moshrefi A, Mount SM, Moy M, Murphy B, Murphy L, Muzny DM, Nelson DL, Nelson DR, Nelson KA, Nixon K, Nusskern DR, Pacleb JM, Palazzolo M, Pittman GS, Pan S, Pollard J, Puri V, Reese MG, Reinert K, Remington K, Saunders RD, Scheeler F, Shen H, Shue BC, Siden-Kiamos I, Simpson M, Skupski MP, Smith T, Spier E, Spradling AC, Stapleton M, Strong R, Sun E, Svirskas R, Tector C, Turner R, Venter E, Wang AH, Wang X, Wang ZY, Wassarman DA, Weinstock GM, Weissenbach J, Williams SM, WoodageT, Worley KC, Wu D, Yang S, Yao QA, Ye J, Yeh RF, Zaveri JS, Zhan M, Zhang G, Zhao Q, Zheng L, Zheng XH, Zhong FN, Zhong W, Zhou X, Zhu S, Zhu X, Smith HO, Gibbs RA, Myers EW, Rubin GM, Venter JC", "evidence": [ { "database": "UniProtKB", "id": "M9PCH6", "url": "https://www.uniprot.org/uniprot/M9PCH6" } ], "reference": [ { "type": "PubMed", "id": "10731132", "url": "https://glygen.org/publication/PubMed/10731132" } ] }, { "title": "Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence.", "journal": "Genome Biol.", "date": "2002", "authors": "Celniker SE, Wheeler DA, Kronmiller B, Carlson JW, Halpern A, Patel S, Adams M, Champe M, Dugan SP, Frise E, Hodgson A, George RA, Hoskins RA, Laverty T, Muzny DM, Nelson CR, Pacleb JM, Park S, Pfeiffer BD, Richards S, Sodergren EJ, Svirskas R, Tabor PE, Wan K, Stapleton M, Sutton GG, Venter C, Weinstock G, Scherer SE, Myers EW, Gibbs RA, Rubin GM", "evidence": [ { "database": "UniProtKB", "id": "M9PCH6", "url": "https://www.uniprot.org/uniprot/M9PCH6" } ], "reference": [ { "type": "PubMed", "id": "12537568", "url": "https://glygen.org/publication/PubMed/12537568" } ] }, { "title": "Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.", "journal": "Genome Biol.", "date": "2002", "authors": "Misra S, Crosby MA, Mungall CJ, Matthews BB, Campbell KS, Hradecky P, Huang Y, Kaminker JS, Millburn GH, Prochnik SE, Smith CD, Tupy JL, Whitfied EJ, Bayraktaroglu L, Berman BP, Bettencourt BR, Celniker SE, de Grey AD, Drysdale RA, Harris NL, Richter J, Russo S, Schroeder AJ, Shu SQ, Stapleton M, Yamada C, Ashburner M, Gelbart WM, Rubin GM, Lewis SE", "evidence": [ { "database": "UniProtKB", "id": "M9PCH6", "url": "https://www.uniprot.org/uniprot/M9PCH6" } ], "reference": [ { "type": "PubMed", "id": "12537572", "url": "https://glygen.org/publication/PubMed/12537572" } ] }, { "title": "The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective.", "journal": "Genome Biol.", "date": "2002", "authors": "Kaminker JS, Bergman CM, Kronmiller B, Carlson J, Svirskas R, Patel S, Frise E, Wheeler DA, Lewis SE, Rubin GM, Ashburner M, Celniker SE", "evidence": [ { "database": "UniProtKB", "id": "M9PCH6", "url": "https://www.uniprot.org/uniprot/M9PCH6" } ], "reference": [ { "type": "PubMed", "id": "12537573", "url": "https://glygen.org/publication/PubMed/12537573" } ] }, { "title": "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly.", "journal": "Genome Biol.", "date": "2002", "authors": "Hoskins RA, Smith CD, Carlson JW, Carvalho AB, Halpern A, Kaminker JS, Kennedy C, Mungall CJ, Sullivan BA, Sutton GG, Yasuhara JC, Wakimoto BT, Myers EW, Celniker SE, Rubin GM, Karpen GH", "evidence": [ { "database": "UniProtKB", "id": "M9PCH6", "url": "https://www.uniprot.org/uniprot/M9PCH6" } ], "reference": [ { "type": "PubMed", "id": "12537574", "url": "https://glygen.org/publication/PubMed/12537574" } ] }, { "title": "Combined evidence annotation of transposable elements in genome sequences.", "journal": "PLoS Comput. Biol.", "date": "2005", "authors": "Quesneville H, Bergman CM, Andrieu O, Autard D, Nouaud D, Ashburner M, Anxolabehere D", "evidence": [ { "database": "UniProtKB", "id": "M9PCH6", "url": "https://www.uniprot.org/uniprot/M9PCH6" } ], "reference": [ { "type": "PubMed", "id": "16110336", "url": "https://glygen.org/publication/PubMed/16110336" } ] }, { "title": "The Release 5.1 annotation of Drosophila melanogaster heterochromatin.", "journal": "Science", "date": "2007", "authors": "Smith CD, Shu S, Mungall CJ, Karpen GH", "evidence": [ { "database": "UniProtKB", "id": "M9PCH6", "url": "https://www.uniprot.org/uniprot/M9PCH6" } ], "reference": [ { "type": "PubMed", "id": "17569856", "url": "https://glygen.org/publication/PubMed/17569856" } ] }, { "title": "Sequence finishing and mapping of Drosophila melanogaster heterochromatin.", "journal": "Science", "date": "2007", "authors": "Hoskins RA, Carlson JW, Kennedy C, Acevedo D, Evans-Holm M, Frise E, Wan KH, Park S, Mendez-Lago M, Rossi F, Villasante A, Dimitri P, Karpen GH, Celniker SE", "evidence": [ { "database": "UniProtKB", "id": "M9PCH6", "url": "https://www.uniprot.org/uniprot/M9PCH6" } ], "reference": [ { "type": "PubMed", "id": "17569867", "url": "https://glygen.org/publication/PubMed/17569867" } ] }, { "title": "The Release 6 reference sequence of the Drosophila melanogaster genome.", "journal": "Genome Res.", "date": "2015", "authors": "Hoskins RA, Carlson JW, Wan KH, Park S, Mendez I, Galle SE, Booth BW, Pfeiffer BD, George RA, Svirskas R, Krzywinski M, Schein J, Accardo MC, Damia E, Messina G, Mendez-Lago M, de Pablos B, Demakova OV, Andreyeva EN, Boldyreva LV, Marra M, Carvalho AB, Dimitri P, Villasante A, Zhimulev IF, Rubin GM, Karpen GH, Celniker SE", "evidence": [ { "database": "UniProtKB", "id": "Q29R16", "url": "https://www.uniprot.org/uniprot/Q29R16" } ], "reference": [ { "type": "PubMed", "id": "25589440", "url": "https://glygen.org/publication/PubMed/25589440" } ] }, { "title": "Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.", "journal": "G3 (Bethesda)", "date": "2015", "authors": "Crosby MA, Gramates LS, Dos Santos G, Matthews BB, St Pierre SE, Zhou P, Schroeder AJ, Falls K, Emmert DB, Russo SM, Gelbart WM", "evidence": [ { "database": "UniProtKB", "id": "Q29R16", "url": "https://www.uniprot.org/uniprot/Q29R16" } ], "reference": [ { "type": "PubMed", "id": "26109356", "url": "https://glygen.org/publication/PubMed/26109356" } ] }, { "title": "Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.", "journal": "G3 (Bethesda)", "date": "2015", "authors": "Matthews BB, Dos Santos G, Crosby MA, Emmert DB, St Pierre SE, Gramates LS, Zhou P, Schroeder AJ, Falls K, Strelets V, Russo SM, Gelbart WM", "evidence": [ { "database": "UniProtKB", "id": "Q29R16", "url": "https://www.uniprot.org/uniprot/Q29R16" } ], "reference": [ { "type": "PubMed", "id": "26109357", "url": "https://glygen.org/publication/PubMed/26109357" } ] } ], "pathway": [ { "id": "dme:Dmel_CG42280", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+dme:Dmel_CG42280", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A4X1VML4-1", "protein_name": "Fibroblast activation protein alpha", "gene_name": "FAP", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MKTWLKIVFGVATSAVLALLVMCIVLRPSRVPNSEGSKTRALTLKDILNGTFSYKTFFPNWISGQEYLHQSTDDNVIFYNIETGESYTILSNTTMKSVNASSYGLSPDRQFAYLESDYSKLWRYSYTATYHIYDLRNGEFITRNELPRPIQYLCWSPVGSKLAYVYQNNIYLKQRPEDPPFQITYNGKENKIFNGIPDWVYEEEMLATKYALWWSPNGRFLAYAEFNDTEIPVIAYSYYGDEQYPRTINIPYPKAGAKNPFVRIFIIDTSYPGHVGPREVPVPAMIASSDYYFSWFTWVTDDRICLQWLKRIQNVSVLSICDFREDWQTWNCPKTQEHIEESRTGWAGGFFVSTPVFSYDAISYYKIFSDKDGYKHIHYIKDSVENAIQITSGKWEAINIFRVTQDSLFYSSNEFEGYPGRRNIYRISIGSHPPSKKCVTCHLREKRCQYYTASFSDYAKYYALVCYGPGLPISTLHDGRTDQEIKILEENKDLEYALKNIRLPKEEIKKLDVDDITLWYKMILPPQFDRSKKYPLLIQVYGGPCSQSVRSVFSIRWISYLASKEGIVIALVDGRGTAFQGDKLLYAVYRKLGVYEVEDQITAVRKFIEMGFIDEKRIAIWGWSYGGYVSSLALASGTGLFKCGIAVAPVSSWEYYASIYTERFMGLPTKDDNLEHYKNSTVMARAEYFRNVDYLLIHGTADDNVHFQNSAQIAKALVNAQVDFQAMWYSDQNHGISGLSTKHLYTHMTHFLKQCFSLPD", "length": 760 }, "evidence": [ { "id": "A2RVG6", "url": "https://omabrowser.org/oma/group/A2RVG6/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "F1NDP3-1", "protein_name": "Fibroblast activation protein alpha", "gene_name": "FAP", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MKTRLKVLFGVVVCVLLSLLLMCIVLLPSKVVTTVDGPRALTLDDYLNGNFQYKTYFPYWVSDSEYLHQNQEDDIILFNVDMNYLTTIMTNSTMKQVNASNYVMSSDKYFIALESNYSKLWRYSYTASYHIYDLIYGGFVTENQLPHKIQYISWSPVGHKLAYVYQNNIYLKQSPREAPIKLTSDGKENEIFNGIPDWVYEEEMLATKYALWWSPSGKYLAYVQFNDSDIPVIEYSYFGEDQYPRKIIIPYPKAGAKNPTVKVFIVDTTNIEAFGPKEVPVPAVIASSDHYFTWLTWVTDSRVGVQWLKRIQNFSVLAICDFKENSNTWDCPENQQHIEESQTGWAGGFFVSAPYFTSDGSSYYKIFSDKNGYKHIHYINGSVENAIQITSGEWEAIYIFRVTNDAIFYSSNEFEGYPGRRNIYKISIGSKPIRKLCITCNLRKERCQYYTARFSERSKYYALICYGPGIPISTLFENESDRELRILEDNQELQSALQEIILPKEEINKLEVDGITLWYKMLIPPQFDRSKKYPLLIQVYGGPCSQNVKHTFSISWITYLASKEGIIVALVDGRGTAYQGDKILHAVYRRLGVYEVEDQISAVKKFIEMGFIDEKRIAIWGWSYGGYVTSLALGSGSGVFKCGIAVAPVSSWEYYASIYTERFMGLPVESDNLEHYKNSTVMARAKNFQNVEYLLIHGTADDNVHFQNSAQIAKALVNAQVDFQAMWYTDQNHGIPGLSSKHLYTHMTHFLKQCFSLSE", "length": 759 }, "evidence": [ { "id": "A2RVG6", "url": "https://omabrowser.org/oma/group/A2RVG6/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "P18962-1", "protein_name": "Dipeptidyl aminopeptidase B", "gene_name": "DAP2", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MEGGEEEVERIPDELFDTKKKHLLDKLIRVGIILVLLIWGTVLLLKSIPHHSNTPDYQEPNSNYTNDGKLKVSFSVVRNNTFQPKYHELQWISDNKIESNDLGLYVTFMNDSYVVKSVYDDSYNSVLLEGKTFIHNGQNLTVESITASPDLKRLLIRTNSVQNWRHSTFGSYFVYDKSSSSFEEIGNEVALAIWSPNSNDIAYVQDNNIYIYSAISKKTIRAVTNDGSSFLFNGKPDWVYEEEVFEDDKAAWWSPTGDYLAFLKIDESEVGEFIIPYYVQDEKDIYPEMRSIKYPKSGTPNPHAELWVYSMKDGTSFHPRISGNKKDGSLLITEVTWVGNGNVLVKTTDRSSDILTVFLIDTIAKTSNVVRNESSNGGWWEITHNTLFIPANETFDRPHNGYVDILPIGGYNHLAYFENSNSSHYKTLTEGKWEVVNGPLAFDSMENRLYFISTRKSSTERHVYYIDLRSPNEIIEVTDTSEDGVYDVSFSSGRRFGLLTYKGPKVPYQKIVDFHSRKAEKCDKGNVLGKSLYHLEKNEVLTKILEDYAVPRKSFRELNLGKDEFGKDILVNSYEILPNDFDETLSDHYPVFFFAYGGPNSQQVVKTFSVGFNEVVASQLNAIVVVVDGRGTGFKGQDFRSLVRDRLGDYEARDQISAASLYGSLTFVDPQKISLFGWSYGGYLTLKTLEKDGGRHFKYGMSVAPVTDWRFYDSVYTERYMHTPQENFDGYVESSVHNVTALAQANRFLLMHGTGDDNVHFQNSLKFLDLLDLNGVENYDVHVFPDSDHSIRYHNANVIVFDKLLDWAKRAFDGQFVK", "length": 818 }, "evidence": [ { "id": "A2RVG6", "url": "https://omabrowser.org/oma/group/A2RVG6/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "P97321-1", "protein_name": "Prolyl endopeptidase FAP", "gene_name": "Fap", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKTWLKTVFGVTTLAALALVVICIVLRPSRVYKPEGNTKRALTLKDILNGTFSYKTYFPNWISEQEYLHQSEDDNIVFYNIETRESYIILSNSTMKSVNATDYGLSPDRQFVYLESDYSKLWRYSYTATYYIYDLQNGEFVRGYELPRPIQYLCWSPVGSKLAYVYQNNIYLKQRPGDPPFQITYTGRENRIFNGIPDWVYEEEMLATKYALWWSPDGKFLAYVEFNDSDIPIIAYSYYGDGQYPRTINIPYPKAGAKNPVVRVFIVDTTYPHHVGPMEVPVPEMIASSDYYFSWLTWVSSERVCLQWLKRVQNVSVLSICDFREDWHAWECPKNQEHVEESRTGWAGGFFVSTPAFSQDATSYYKIFSDKDGYKHIHYIKDTVENAIQITSGKWEAIYIFRVTQDSLFYSSNEFEGYPGRRNIYRISIGNSPPSKKCVTCHLRKERCQYYTASFSYKAKYYALVCYGPGLPISTLHDGRTDQEIQVLEENKELENSLRNIQLPKVEIKKLKDGGLTFWYKMILPPQFDRSKKYPLLIQVYGGPCSQSVKSVFAVNWITYLASKEGIVIALVDGRGTAFQGDKFLHAVYRKLGVYEVEDQLTAVRKFIEMGFIDEERIAIWGWSYGGYVSSLALASGTGLFKCGIAVAPVSSWEYYASIYSERFMGLPTKDDNLEHYKNSTVMARAEYFRNVDYLLIHGTADDNVHFQNSAQIAKALVNAQVDFQAMWYSDQNHGISSGRSQNHLYTHMTHFLKQCFSLSD", "length": 761 }, "evidence": [ { "id": "A2RVG6", "url": "https://omabrowser.org/oma/group/A2RVG6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q12884-1", "protein_name": "Prolyl endopeptidase FAP", "gene_name": "FAP", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MKTWVKIVFGVATSAVLALLVMCIVLRPSRVHNSEENTMRALTLKDILNGTFSYKTFFPNWISGQEYLHQSADNNIVLYNIETGQSYTILSNRTMKSVNASNYGLSPDRQFVYLESDYSKLWRYSYTATYYIYDLSNGEFVRGNELPRPIQYLCWSPVGSKLAYVYQNNIYLKQRPGDPPFQITFNGRENKIFNGIPDWVYEEEMLATKYALWWSPNGKFLAYAEFNDTDIPVIAYSYYGDEQYPRTINIPYPKAGAKNPVVRIFIIDTTYPAYVGPQEVPVPAMIASSDYYFSWLTWVTDERVCLQWLKRVQNVSVLSICDFREDWQTWDCPKTQEHIEESRTGWAGGFFVSTPVFSYDAISYYKIFSDKDGYKHIHYIKDTVENAIQITSGKWEAINIFRVTQDSLFYSSNEFEEYPGRRNIYRISIGSYPPSKKCVTCHLRKERCQYYTASFSDYAKYYALVCYGPGIPISTLHDGRTDQEIKILEENKELENALKNIQLPKEEIKKLEVDEITLWYKMILPPQFDRSKKYPLLIQVYGGPCSQSVRSVFAVNWISYLASKEGMVIALVDGRGTAFQGDKLLYAVYRKLGVYEVEDQITAVRKFIEMGFIDEKRIAIWGWSYGGYVSSLALASGTGLFKCGIAVAPVSSWEYYASVYTERFMGLPTKDDNLEHYKNSTVMARAEYFRNVDYLLIHGTADDNVHFQNSAQIAKALVNAQVDFQAMWYSDQNHGLSGLSTNHLYTHMTHFLKQCFSLSD", "length": 760 }, "evidence": [ { "id": "A2RVG6", "url": "https://omabrowser.org/oma/group/A2RVG6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8R492-1", "protein_name": "Fibroblast activation protein, alpha", "gene_name": "Fap", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MKTWLKTVFGVTTLVALALVVICIVLRPSRVYSPEGNTGRSLTLKDILNGTFSYKTYFPNWISEQEYLHQSEDDNIVFYNIETRESYIILSNSTMKSVNATDYGLSPDRQFIYLESDYSKLWRYSYTATYYIYDLQNGEFVRGYELPRPIQYLCWSPVGSKLAYVYQNNIYLKQRPGDPPFQITYTGRENRIFNGIPDWVYEEEMLATKYALWWSPDGKYLAYVEFNDSDIPIIAYSYYGDGQYPRTINIPYPKAGAKNPIVRVFIVDTIYPHHVGPIEVPVPEMIASSDYYFTWLTWVTNERVCLQWLKRVQNVSVLSICDFREDWHAWDCPKNQEHIEESRTGWAGGFFVSTPAFSQDAASYYKIFSDKDGYKHIHYIKDTVENAIQITSGKWEAIYIFRVTQDSLFYSSNEFEGYPGRRNIYRISIGNSPPSKKCVTCHLRKERCQYYTASFSYKAKYYALICYGPGLPISTLHDGRTDQEIQVLEENKELENALRNIQLPAVEIKKLEDGGMTFWYKMILPPQFDRSKKYPLLIQVYGGPCSQSVKSVFSVNWITYLASKEGIVVALVDGRGTAFQGDKFLHAVYRKLGVYEVEDQLTAVRKFIEMGFIDEGRIAIWGWSYGGYVSSLALASGTGLFKCGIAVAPVSSWEYYASIYTERFMGLPTKDDNLEHYKNSTVMARAEYFRNVDYLLIHGTADDNVHFQNSAQIAKALVNAQVDFQAMWYSDQNHGISSGRSQNHLYTHMTHFLKQCFSLSD", "length": 761 }, "evidence": [ { "id": "A2RVG6", "url": "https://omabrowser.org/oma/group/A2RVG6/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "dipeptidyl-peptidase activity", "id": "GO:0008239", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008239", "evidence": [ { "database": "UniProtKB", "id": "A2RVG6", "url": "https://www.uniprot.org/uniprot/A2RVG6" } ], "pmid": "" }, { "name": "serine hydrolase activity", "id": "GO:0017171", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017171", "evidence": [ { "database": "UniProtKB", "id": "A2RVG6", "url": "https://www.uniprot.org/uniprot/A2RVG6" } ], "pmid": "" }, { "name": "serine-type peptidase activity", "id": "GO:0008236", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008236", "evidence": [ { "database": "UniProtKB", "id": "A2RVG6", "url": "https://www.uniprot.org/uniprot/A2RVG6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A2RVG6", "url": "https://www.uniprot.org/uniprot/A2RVG6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "proteolysis", "id": "GO:0006508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006508", "evidence": [ { "database": "UniProtKB", "id": "A2RVG6", "url": "https://www.uniprot.org/uniprot/A2RVG6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 126, "end_pos": 128, "annotation": "n_glycosylation_sequon" }, { "start_pos": 324, "end_pos": 326, "annotation": "n_glycosylation_sequon" }, { "start_pos": 338, "end_pos": 340, "annotation": "n_glycosylation_sequon" }, { "start_pos": 620, "end_pos": 622, "annotation": "n_glycosylation_sequon" }, { "start_pos": 763, "end_pos": 765, "annotation": "n_glycosylation_sequon" }, { "start_pos": 76, "end_pos": 78, "annotation": "n_glycosylation_sequon" }, { "start_pos": 839, "end_pos": 841, "annotation": "n_glycosylation_sequon" }, { "start_pos": 877, "end_pos": 879, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.4.14.4", "ec_name": "Release of an N-terminal dipeptide from a peptide comprising four or more residues, with broad specificity. Also acts on dipeptidyl 2-naphthylamides.", "evidence": [ { "id": "3.4.14.4", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.4.14.4" } ] }, { "ec_number": "3.4.14.5", "ec_name": "Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.", "evidence": [ { "id": "3.4.14.5", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.4.14.5" } ] }, { "ec_number": "3.4.14.2", "ec_name": "Release of an N-terminal dipeptide, Xaa-Yaa-|-, preferentially when Yaa is Ala or Pro. 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