{
    "uniprot_canonical_ac": "A2AWP0-1",
    "uniprot_ac": "A2AWP0",
    "uniprot_id": "BIRC7_MOUSE",
    "mass": {
        "chemical_mass": 31992.0,
        "monoisotopic_mass": 31992.0
    },
    "refseq": {
        "ac": "NP_001156719",
        "name": "baculoviral IAP repeat-containing protein 7 precursor",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156719"
    },
    "gene_names": [
        {
            "name": "Birc7",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/A2AWP0",
            "id": "A2AWP0"
        },
        {
            "name": "Birc7",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156719",
            "id": "NP_001156719"
        },
        {
            "name": "E130019N06; KIAP; Livin; ML-IAP",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156719",
            "id": "NP_001156719"
        },
        {
            "name": "Livin",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A2AWP0",
            "id": "A2AWP0"
        }
    ],
    "protein_names": [
        {
            "name": "Baculoviral IAP repeat-containing protein 7",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprotkb/A2AWP0/entry#names_and_taxonomy",
            "id": "A2AWP0"
        },
        {
            "name": "2.3.2.27",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprotkb/A2AWP0/entry#names_and_taxonomy",
            "id": "A2AWP0"
        },
        {
            "name": "Livin",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprotkb/A2AWP0/entry#names_and_taxonomy",
            "id": "A2AWP0"
        },
        {
            "name": "RING-type E3 ubiquitin transferase BIRC7",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprotkb/A2AWP0/entry#names_and_taxonomy",
            "id": "A2AWP0"
        },
        {
            "name": "baculoviral IAP repeat-containing protein 7 precursor",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156719",
            "id": "NP_001156719"
        },
        {
            "name": "baculoviral IAP repeat-containing protein 7; RING-type E3 ubiquitin transferase BIRC7",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156719",
            "id": "NP_001156719"
        }
    ],
    "function": [
        {
            "annotation": "Apoptotic regulator capable of exerting proapoptotic and anti-apoptotic activities and plays crucial roles in apoptosis, cell proliferation, and cell cycle control. Its anti-apoptotic activity is mediated through the inhibition of CASP3, CASP7 and CASP9, as well as by its E3 ubiquitin-protein ligase activity. As it is a weak caspase inhibitor, its anti-apoptotic activity is thought to be due to its ability to ubiquitinate DIABLO/SMAC targeting it for degradation thereby promoting cell survival. May contribute to caspase inhibition, by blocking the ability of DIABLO/SMAC to disrupt XIAP/BIRC4-caspase interactions. Protects against apoptosis induced by TNF or by chemical agents such as adriamycin, etoposide or staurosporine. Suppression of apoptosis is mediated by activation of MAPK8/JNK1, and possibly also of MAPK9/JNK2. This activation depends on TAB1 and MAP3K7/TAK1. In vitro, inhibits CASP3 and proteolytic activation of pro-CASP9.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2AWP0",
                    "url": "https://www.uniprot.org/uniprot/A2AWP0#function"
                },
                {
                    "database": "UniProtKB",
                    "id": "Q96CA5",
                    "url": "https://www.uniprot.org/uniprot/Q96CA5#function"
                }
            ]
        },
        {
            "annotation": "Birc7 is a late fiber gene of the mouse lens. Its expression in cells bordering the OFZ is consistent with a role in organelle degradation, a process in which the ubiquitin proteasome pathway has been implicated previously.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001156719",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156719"
                },
                {
                    "database": "PubMed",
                    "id": "26218911",
                    "url": "https://glygen.org/publication/PubMed/26218911"
                }
            ]
        },
        {
            "annotation": "Data showed that Livin knock-down suppressed cell proliferation and inhibited cell invasion, accompanied by downregulation of VEGF and MMP-2/-9. Its silencing resulted in the prevention of xenograft tumor formation.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001156719",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156719"
                },
                {
                    "database": "PubMed",
                    "id": "26094984",
                    "url": "https://glygen.org/publication/PubMed/26094984"
                }
            ]
        },
        {
            "annotation": "Livin expression promotes keratinocyte release of inflammatory mediators in psoriasis.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001156719",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156719"
                },
                {
                    "database": "PubMed",
                    "id": "38332513",
                    "url": "https://glygen.org/publication/PubMed/38332513"
                }
            ]
        },
        {
            "annotation": "Livin is protective in UVB-induced skin photodamage by regulating keratinocyte activation and inflammatory responses.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001156719",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156719"
                },
                {
                    "database": "PubMed",
                    "id": "38332512",
                    "url": "https://glygen.org/publication/PubMed/38332512"
                }
            ]
        },
        {
            "annotation": "Livin upregulation in keratinocytes of psoriasis patients to promote adhesion molecule expression.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001156719",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156719"
                },
                {
                    "database": "PubMed",
                    "id": "36916467",
                    "url": "https://glygen.org/publication/PubMed/36916467"
                }
            ]
        },
        {
            "annotation": "ML-IAP is dispensable for both normal mouse development and ocular homoeostasis.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001156719",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156719"
                },
                {
                    "database": "PubMed",
                    "id": "22853455",
                    "url": "https://glygen.org/publication/PubMed/22853455"
                }
            ]
        },
        {
            "annotation": "The overexpression of PTEN concomitant with Livin gene silencing was confirmed as a feasible and effective in vitro and in vivo gene modulation method, which may represent a potential therapeutic strategy for the treatment of Gastric Cancer.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001156719",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156719"
                },
                {
                    "database": "PubMed",
                    "id": "29436592",
                    "url": "https://glygen.org/publication/PubMed/29436592"
                }
            ]
        }
    ],
    "disease": [
        {
            "disease_id": "DOID:0050860",
            "recommended_name": {
                "id": "DOID:0050860",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:0050860",
                "name": "colorectal adenoma",
                "description": "An intestinal benign neoplasm that has_material_basis_in epithelial tissue of glandular origin and is located_in colon and located_in rectum."
            },
            "synonyms": [],
            "evidence": [
                {
                    "id": "0050860",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050860"
                }
            ]
        },
        {
            "disease_id": "DOID:0050861",
            "recommended_name": {
                "id": "DOID:0050861",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:0050861",
                "name": "colorectal adenocarcinoma",
                "description": "A colorectal carcinoma that derives_from epithelial cells of glandular origin."
            },
            "synonyms": [],
            "evidence": [
                {
                    "id": "0050861",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050861"
                }
            ]
        }
    ],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Mus musculus",
            "taxid": 10090,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2AWP0",
                    "url": "https://www.uniprot.org/uniprot/A2AWP0"
                }
            ],
            "common_name": "Mouse",
            "glygen_name": "Mouse",
            "reference_species": "Mus musculus [10090]"
        }
    ],
    "gene": [
        {
            "name": "Birc7",
            "url": "https://www.uniprot.org/uniprot/A2AWP0",
            "locus": {
                "chromosome": "2",
                "start_pos": 180575803,
                "end_pos": 180570816,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSMUSG00000038840",
                        "url": "https://www.ensembl.org/id/ENSMUSG00000038840"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSMUSG00000038840",
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000038840",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "cd00022",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00022",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "cd16713",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16713",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "329581",
            "url": "https://www.ncbi.nlm.nih.gov/gene/329581",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "IPR001370",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001370",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR001841",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001841",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR013083",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR013083",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR017907",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR017907",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "mmu:329581",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:329581",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "2676458",
            "url": "http://www.informatics.jax.org/marker/MGI:2676458",
            "database": "MGI",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "WEHGDDP",
            "url": "https://omabrowser.org/oma/group/WEHGDDP/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "383715at2759",
            "url": "http://www.orthodb.org/?query=383715at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR10044",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10044",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR10044:SF163",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10044:SF163",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF00653",
            "url": "http://pfam.xfam.org/family/PF00653",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF13920",
            "url": "http://pfam.xfam.org/family/PF13920",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PR_A2AWP0",
            "url": "http://purl.obolibrary.org/obo/PR_A2AWP0",
            "database": "PRO",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "NP_001156719",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156719",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A2AWP0",
            "url": "https://www.uniprot.org/uniprot/A2AWP0",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A2AWP0-1",
            "url": "https://www.uniprot.org/uniprot/A2AWP0-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MFSPADLFRAAVFSMGPESRARDSVRGPELSHREDGSGRTQEQDKPHCPCNHVLGQDCLDGQILGQLRPLSEEEESSGAAFLGEPAFPEMDSEDLRLASFYDWPSTAGIQPEPLAAAGFFHTGQQDKVRCFFCYGGLQSWERGDDPWTEHARWFPRCQFLLRSKGRDFVERIQTYTPLLGSWDQREEPEDAVSATPSAPAHGSPELLRSRRETQPEDVSEPGAKDVQEQLRQLQEERRCKVCLDRAVSIVFVPCGHFVCTECAPNLQLCPICRVPICSCVRTFLS",
        "length": 285,
        "header": "sp|A2AWP0-1|BIRC7_MOUSE Isoform 1 of Baculoviral IAP repeat-containing protein 7  OS=Mus musculus OX=10090 GN=Birc7 PE=2 SV=1 CANONICAL=A2AWP0-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A2AWP0-1",
            "url": "https://www.uniprot.org/uniprotkb/A2AWP0/entry#A2AWP0-1",
            "sequence": {
                "sequence": "MFSPADLFRAAVFSMGPESRARDSVRGPELSHREDGSGRTQEQDKPHCPCNHVLGQDCLDGQILGQLRPLSEEEESSGAAFLGEPAFPEMDSEDLRLASFYDWPSTAGIQPEPLAAAGFFHTGQQDKVRCFFCYGGLQSWERGDDPWTEHARWFPRCQFLLRSKGRDFVERIQTYTPLLGSWDQREEPEDAVSATPSAPAHGSPELLRSRRETQPEDVSEPGAKDVQEQLRQLQEERRCKVCLDRAVSIVFVPCGHFVCTECAPNLQLCPICRVPICSCVRTFLS",
                "length": 285,
                "header": "sp|A2AWP0-1|BIRC7_MOUSE Isoform 1 of Baculoviral IAP repeat-containing protein 7  OS=Mus musculus OX=10090 GN=Birc7 PE=2 SV=1 CANONICAL=A2AWP0-1"
            },
            "locus": {
                "chromosome": "2",
                "start_pos": 180575120,
                "end_pos": 180570940,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000108875.2",
                        "url": "https://www.ensembl.org/id/ENSMUST00000108875.2"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000104503.2",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000104503.2"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [
        "enzyme"
    ],
    "publication": [
        {
            "title": "Characterization of ML-IAP protein stability and physiological role in vivo.",
            "journal": "The Biochemical journal",
            "date": "2012",
            "authors": "Varfolomeev E, Moradi E, Dynek JN, Zha J, Fedorova AV, Deshayes K, Fairbrother WJ, Newton K, Le Couter J, Vucic D",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001156719",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156719"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "22853455",
                    "url": "https://glygen.org/publication/PubMed/22853455"
                }
            ]
        },
        {
            "title": "Silencing of Livin inhibits tumorigenesis and metastasis via VEGF and MMPs pathway in lung cancer.",
            "journal": "International journal of oncology",
            "date": "2015",
            "authors": "Lin X, Li HR, Lin XF, Yu ME, Tu XW, Hua ZD, Lin M, Xu NL, Han LL, Chen YS",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001156719",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156719"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "26094984",
                    "url": "https://glygen.org/publication/PubMed/26094984"
                }
            ]
        },
        {
            "title": "Birc7: A Late Fiber Gene of the Crystalline Lens.",
            "journal": "Investigative ophthalmology & visual science",
            "date": "2015",
            "authors": "De Maria A, Bassnett S",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001156719",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156719"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "26218911",
                    "url": "https://glygen.org/publication/PubMed/26218911"
                }
            ]
        },
        {
            "title": "Concomitant modulation of PTEN and Livin in gastric cancer treatment.",
            "journal": "International journal of molecular medicine",
            "date": "2018",
            "authors": "Zhao CL, Han SN, Wang ZJ, Wang SH, Zhao GQ, Zhang XF, Wang JX",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001156719",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156719"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "29436592",
                    "url": "https://glygen.org/publication/PubMed/29436592"
                }
            ]
        },
        {
            "title": "Livin upregulation in keratinocytes of psoriasis patients to promote adhesion molecule expression.",
            "journal": "International journal of dermatology",
            "date": "2023-03-14",
            "authors": "Che Delu, Hang Bing, Li Yazhuo, Li Kaili, Wang Kaijie, Wang Hao",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001156719",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156719"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "36916467",
                    "url": "https://glygen.org/publication/PubMed/36916467"
                }
            ]
        },
        {
            "title": "Livin is protective in UVB-induced skin photodamage by regulating keratinocyte activation and inflammatory responses.",
            "journal": "Journal of cellular and molecular medicine",
            "date": "2024-02",
            "authors": "Wang Kaijie, You Xiaolan, Qu Zhenri, Che Delu, Cao Xianwei",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001156719",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156719"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "38332512",
                    "url": "https://glygen.org/publication/PubMed/38332512"
                }
            ]
        },
        {
            "title": "Livin expression promotes keratinocyte release of inflammatory mediators in psoriasis.",
            "journal": "Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)",
            "date": "2024-02",
            "authors": "Che Delu, Li Yazhuo, Hang Bing, Li Kaili, Wang Kaijie, Wang Hao",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001156719",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156719"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "38332513",
                    "url": "https://glygen.org/publication/PubMed/38332513"
                }
            ]
        }
    ],
    "pathway": [
        {
            "id": "mmu:329581",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:329581",
            "resource": "KEGG Pathway"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "D4A690-1",
            "protein_name": "Baculoviral IAP repeat-containing 7",
            "gene_name": "Birc7",
            "tax_id": 10116,
            "organism": "Rattus norvegicus",
            "sequence": {
                "sequence": "MFSPAGLLRAAVLPMGPESKDRDSFCGPELSHREESNGPTQEQHRPHCPCNRVLGQDCLDGQILGQLRPLSEEEESSGATFVGEPAFPEMDSEDLRLASFYDWPSTAGIQPEPLAAAGFFHTGQQDKVRCFFCYGGLQSWERGDDPWTEHARWFPRCQFLLRSKGRDFVERIQAYTPLLGSWEQREEQEDTVSATPSAPTHGSPELLRSRRETQSEDASEPGAEDVQEQLRQLQEERRCKVCLDRAVSVVFVPCGHFVCTECAPNLRLCPICRVPICNCVRTFLS",
                "length": 285
            },
            "evidence": [
                {
                    "id": "46368556",
                    "url": "http://www.informatics.jax.org/homology/46368556",
                    "database": "MGI"
                },
                {
                    "id": "A2AWP0",
                    "url": "https://omabrowser.org/oma/group/A2AWP0/",
                    "database": "OMA"
                }
            ],
            "glygen_name": "Rat",
            "common_name": "Rat"
        },
        {
            "uniprot_canonical_ac": "Q96CA5-1",
            "protein_name": "Baculoviral IAP repeat-containing protein 7",
            "gene_name": "BIRC7",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MGPKDSAKCLHRGPQPSHWAAGDGPTQERCGPRSLGSPVLGLDTCRAWDHVDGQILGQLRPLTEEEEEEGAGATLSRGPAFPGMGSEELRLASFYDWPLTAEVPPELLAAAGFFHTGHQDKVRCFFCYGGLQSWKRGDDPWTEHAKWFPSCQFLLRSKGRDFVHSVQETHSQLLGSWDPWEEPEDAAPVAPSVPASGYPELPTPRREVQSESAQEPGGVSPAEAQRAWWVLEPPGARDVEAQLRRLQEERTCKVCLDRAVSIVFVPCGHLVCAECAPGLQLCPICRAPVRSRVRTFLS",
                "length": 298
            },
            "evidence": [
                {
                    "id": "46368556",
                    "url": "http://www.informatics.jax.org/homology/46368556",
                    "database": "MGI"
                },
                {
                    "id": "A2AWP0",
                    "url": "https://omabrowser.org/oma/group/A2AWP0/",
                    "database": "OMA"
                }
            ],
            "glygen_name": "Human",
            "common_name": "Human"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Cellular Component",
                "total": 6,
                "go_terms": [
                    {
                        "name": "nucleus",
                        "id": "GO:0005634",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AWP0",
                                "url": "https://www.uniprot.org/uniprot/A2AWP0"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "nucleoplasm",
                        "id": "GO:0005654",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AWP0",
                                "url": "https://www.uniprot.org/uniprot/A2AWP0"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cytoplasm",
                        "id": "GO:0005737",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AWP0",
                                "url": "https://www.uniprot.org/uniprot/A2AWP0"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "Golgi apparatus",
                        "id": "GO:0005794",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AWP0",
                                "url": "https://www.uniprot.org/uniprot/A2AWP0"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "centrosome",
                        "id": "GO:0005813",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AWP0",
                                "url": "https://www.uniprot.org/uniprot/A2AWP0"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cytosol",
                        "id": "GO:0005829",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AWP0",
                                "url": "https://www.uniprot.org/uniprot/A2AWP0"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Biological Process",
                "total": 11,
                "go_terms": [
                    {
                        "name": "regulation of cell population proliferation",
                        "id": "GO:0042127",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042127",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AWP0",
                                "url": "https://www.uniprot.org/uniprot/A2AWP0"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "negative regulation of apoptotic process",
                        "id": "GO:0043066",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043066",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AWP0",
                                "url": "https://www.uniprot.org/uniprot/A2AWP0"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "positive regulation of JNK cascade",
                        "id": "GO:0046330",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046330",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AWP0",
                                "url": "https://www.uniprot.org/uniprot/A2AWP0"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "apoptotic process",
                        "id": "GO:0006915",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006915",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AWP0",
                                "url": "https://www.uniprot.org/uniprot/A2AWP0"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "protein ubiquitination",
                        "id": "GO:0016567",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016567",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AWP0",
                                "url": "https://www.uniprot.org/uniprot/A2AWP0"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "positive regulation of protein ubiquitination",
                        "id": "GO:0031398",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031398",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AWP0",
                                "url": "https://www.uniprot.org/uniprot/A2AWP0"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "regulation of apoptotic process",
                        "id": "GO:0042981",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042981",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AWP0",
                                "url": "https://www.uniprot.org/uniprot/A2AWP0"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "negative regulation of tumor necrosis factor-mediated signaling pathway",
                        "id": "GO:0010804",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010804",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AWP0",
                                "url": "https://www.uniprot.org/uniprot/A2AWP0"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "regulation of cell cycle",
                        "id": "GO:0051726",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051726",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AWP0",
                                "url": "https://www.uniprot.org/uniprot/A2AWP0"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "regulation of natural killer cell apoptotic process",
                        "id": "GO:0070247",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070247",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AWP0",
                                "url": "https://www.uniprot.org/uniprot/A2AWP0"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "lens development in camera-type eye",
                        "id": "GO:0002088",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002088",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AWP0",
                                "url": "https://www.uniprot.org/uniprot/A2AWP0"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Molecular Function",
                "total": 5,
                "go_terms": [
                    {
                        "name": "metal ion binding",
                        "id": "GO:0046872",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AWP0",
                                "url": "https://www.uniprot.org/uniprot/A2AWP0"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "ubiquitin protein ligase activity",
                        "id": "GO:0061630",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061630",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AWP0",
                                "url": "https://www.uniprot.org/uniprot/A2AWP0"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "ubiquitin-protein transferase activity",
                        "id": "GO:0004842",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004842",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AWP0",
                                "url": "https://www.uniprot.org/uniprot/A2AWP0"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cysteine-type endopeptidase inhibitor activity involved in apoptotic process",
                        "id": "GO:0043027",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043027",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AWP0",
                                "url": "https://www.uniprot.org/uniprot/A2AWP0"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cysteine-type endopeptidase inhibitor activity",
                        "id": "GO:0004869",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004869",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AWP0",
                                "url": "https://www.uniprot.org/uniprot/A2AWP0"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            }
        ]
    },
    "pro_annotation": [],
    "site_annotation": [],
    "ptm_annotation": [],
    "interactions": [],
    "reactions": [],
    "reaction_participants": [],
    "reaction_enzymes": [],
    "biomarkers": [],
    "synthesized_glycans": [],
    "enzyme_annotation": [
        {
            "ec_number": "2.3.2.27",
            "ec_name": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
            "evidence": [
                {
                    "id": "2.3.2.27",
                    "database": "BRENDA Enzymes",
                    "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.3.2.27"
                }
            ]
        }
    ],
    "cluster_types": [
        {
            "name": "homologset.mgi",
            "label": "MGI Homologs"
        },
        {
            "name": "homologset.oma",
            "label": "OMA Homologs"
        }
    ],
    "sequence_features": {
        "n_linked_sites": [],
        "o_linked_sites": [],
        "snv_sites": [],
        "glycation_sites": [],
        "phosphorylation_sites": [],
        "sequon_annotation_sites": []
    },
    "section_stats": [
        {
            "table_id": "glycosylation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_reported",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_reported_with_glycan",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_predicted",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_automatic_literature_mining",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "phosphorylation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "snv",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "snv_disease",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "snv_non_disease",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "publication",
            "table_stats": [
                {
                    "field": "total",
                    "count": 7
                }
            ],
            "sort_fields": [
                "title",
                "journal",
                "date",
                "authors"
            ]
        }
    ]
}