{ "uniprot_canonical_ac": "A2AQ92-1", "uniprot_ac": "A2AQ92", "uniprot_id": "A2AQ92_MOUSE", "mass": { "chemical_mass": 177132.0, "monoisotopic_mass": 177132.0 }, "refseq": { "ac": "NP_001092767", "name": "dual oxidase 1 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092767" }, "gene_names": [ { "name": "Duox1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A2AQ92", "id": "A2AQ92" }, { "name": "9930101G15Rik; Duox2; LNOX1; LNOX2; NOXEF1; NOXEF2; P138-TOX; THOX1; THOX2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092767", "id": "NP_001092767" }, { "name": "Duox1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092767", "id": "NP_001092767" } ], "protein_names": [ { "name": "NAD(P)H oxidase (H2O2-forming)", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprotkb/A2AQ92/entry#names_and_taxonomy", "id": "A2AQ92" }, { "name": "1.6.3.1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A2AQ92/entry#names_and_taxonomy", "id": "A2AQ92" }, { "name": "dual oxidase 1 precursor", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092767", "id": "NP_001092767" }, { "name": "dual oxidase 2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092767", "id": "NP_001092767" } ], "function": [ { "annotation": "Diet-induced obesity worsens allergen-induced type 2/type 17 inflammation in airways by enhancing DUOX1 activation.", "evidence": [ { "database": "RefSeq", "id": "NP_001092767", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092767" }, { "database": "PubMed", "id": "36625485", "url": "https://glygen.org/publication/PubMed/36625485" } ] }, { "annotation": "Dual oxidase 1 is dispensable during Mycobacterium tuberculosis infection in mice. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001092767", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092767" }, { "database": "PubMed", "id": "36936954", "url": "https://glygen.org/publication/PubMed/36936954" } ] }, { "annotation": "Dual oxidase 1 promotes antiviral innate immunity. Erratum:[Proc Natl Acad Sci U S A. 2021 Dec 7;118(49):. PMID: 34845039]", "evidence": [ { "database": "RefSeq", "id": "NP_001092767", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092767" }, { "database": "PubMed", "id": "34168077", "url": "https://glygen.org/publication/PubMed/34168077" } ] }, { "annotation": "Duox1 is the main source of H(2)O(2) in the rat thyroid cell line PCCl3.", "evidence": [ { "database": "RefSeq", "id": "NP_001092767", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092767" }, { "database": "PubMed", "id": "17643428", "url": "https://glygen.org/publication/PubMed/17643428" } ] }, { "annotation": "Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain.", "evidence": [ { "database": "UniProtKB", "id": "A2AQ92", "url": "https://www.uniprot.org/uniprot/A2AQ92#function" }, { "database": "UniProtKB", "id": "ARBA00003796", "url": "https://www.uniprot.org/uniprot/ARBA00003796#function" } ] }, { "annotation": "Oxidation-Dependent Activation of Src Kinase Mediates Epithelial IL-33 Production and Signaling during Acute Airway Allergen Challenge.", "evidence": [ { "database": "RefSeq", "id": "NP_001092767", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092767" }, { "database": "PubMed", "id": "34088769", "url": "https://glygen.org/publication/PubMed/34088769" } ] } ], "disease": [ { "disease_id": "DOID:0050328", "recommended_name": { "id": "DOID:0050328", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050328", "name": "congenital hypothyroidism", "description": "A hypothyroidism that is present at birth." }, "synonyms": [ { "id": "MONDO:0010142", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010142", "name": "hypothyroidism due to TSH receptor mutations", "description": "Hypothyroidism due to thyroid-stimulating hormone (TSH) receptor mutations is a type of primary congenital hypothyroidism, a permanent thyroid hormone deficiency that is present from birth due to thyroid resistance to TSH." }, { "id": "MONDO:0010142", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010142", "name": "CHNG1", "description": "" }, { "id": "MONDO:0010142", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010142", "name": "TSH resistance", "description": "" }, { "id": "MONDO:0010142", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010142", "name": "hypothyroidism, congenital, nongoitrous, type 1", "description": "" }, { "id": "MONDO:0010142", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010142", "name": "congenital nongoitrous hypothryoidism 1", "description": "" }, { "id": "MONDO:0010142", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010142", "name": "congenital nongoitrous hypothyroidism 1", "description": "" }, { "id": "MONDO:0010142", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010142", "name": "hypothyroidism due to unresponsiveness to thyrotropin", "description": "" }, { "id": "MONDO:0010142", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010142", "name": "hypothyroidism, Nonautoimmune", "description": "" }, { "id": "MONDO:0010142", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010142", "name": "hypothyroidism, congenital, due to TSH resistance", "description": "" }, { "id": "MONDO:0010142", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010142", "name": "hypothyroidism, congenital, nongoitrous, 1", "description": "" }, { "id": "MONDO:0010142", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010142", "name": "thyroid-stimulating hormone, resistance to", "description": "" }, { "id": "MONDO:0010142", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010142", "name": "thyrotropin resistance", "description": "" }, { "id": "MIM:275200", "resource": "MIM", "url": "https://www.omim.org/entry/275200", "name": "Hypothyroidism, congenital, non-goitrous, 1", "description": "Hypothyroidism, congenital, non-goitrous, 1" } ], "evidence": [ { "id": "0050328", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0050328" } ] }, { "disease_id": "DOID:0050338", "recommended_name": { "id": "DOID:0050338", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050338", "name": "primary bacterial infectious disease", "description": "A bacterial infectious disease that results_in infection by bacteria as a result of their presence or activity within the normal, healthy host, and their intrinsic virulence is, in part, a necessary consequence of their need to reproduce and spread." }, "synonyms": [], "evidence": [ { "id": "0050338", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0050338" } ] }, { "disease_id": "DOID:1459", "recommended_name": { "id": "DOID:1459", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1459", "name": "hypothyroidism", "description": "A thyroid gland disease which involves an underproduction of thyroid hormone." }, "synonyms": [ { "id": "DOID:1459", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1459", "name": "Thyroid deficiency", "description": "" }, { "id": "DOID:1459", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1459", "name": "Thyroid insufficiency", "description": "" } ], "evidence": [ { "id": "1459", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:1459" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "A2AQ92", "url": "https://www.uniprot.org/uniprot/A2AQ92" } ], "common_name": "Mouse", "glygen_name": "Mouse", "reference_species": "Mus musculus [10090]" } ], "gene": [ { "name": "Duox1", "url": "https://www.uniprot.org/uniprot/A2AQ92", "locus": { "chromosome": "2", "start_pos": 122178453, "end_pos": 122146153, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000033268", "url": "https://www.ensembl.org/id/ENSMUSG00000033268" } ] } } ], "crossref": [ { "id": "ENSMUSG00000033268", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000033268", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00051", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00051", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd06186", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06186", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd09820", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd09820", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "99439", "url": "https://www.ncbi.nlm.nih.gov/gene/99439", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "GPDB0001706", "url": "https://acgg.asia/db/gpdb/symbol/GPDB0001706", "database": "GlycoProtDB", "categories": [ "Glycoproteomics" ] }, { "id": "IPR002048", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002048", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR010255", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010255", "database": "InterPro", "categories": [ 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"https://omabrowser.org/oma/group/VTSEIIM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "367877at2759", "url": "http://www.orthodb.org/?query=367877at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11972", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11972", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11972:SF75", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11972:SF75", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "6WXR", "url": "https://www.rcsb.org/structure/6WXR", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "6WXU", "url": "https://www.rcsb.org/structure/6WXU", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "6WXV", "url": "https://www.rcsb.org/structure/6WXV", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF00036", "url": "http://pfam.xfam.org/family/PF00036", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF01794", "url": "http://pfam.xfam.org/family/PF01794", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF03098", "url": "http://pfam.xfam.org/family/PF03098", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF08022", "url": "http://pfam.xfam.org/family/PF08022", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF08030", "url": "http://pfam.xfam.org/family/PF08030", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF13499", "url": "http://pfam.xfam.org/family/PF13499", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "R-MMU-209968", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-209968", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_001092767", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092767", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "11260", "url": "https://www.rhea-db.org/rhea/11260", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "11264", "url": "https://www.rhea-db.org/rhea/11264", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A2AQ92", "url": "https://www.uniprot.org/uniprot/A2AQ92", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A2AQ92-1", "url": "https://www.uniprot.org/uniprot/A2AQ92-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGFHLALAWILLVGTLASLGAQNSISWEVQRFDGWYNNLMEHRWGSKGSRLQRLVPASYADGVYQPLKEPYLPNPRHLSNRVMRGSAGQPSLRNRTVLGVFFGYHVLSDLVSVETPGCPAEFLNIYIPHGDPVFDPDKRGNVVLPFQRSRWDRNTGQSPSNPRDQSNQVTGWLDGSAIYGSSHSWSDTLRSFSGGQLASGPDPAFPSDSQSSLLMWMAPDPSTGQGGPRGVYAFGAQRGNREPFLQALGLLWFRYHNLCARKLAQEHPHWGDEELFQHARKRVIATYQNIAMYEWLPSFLKQTPPEYPGYRPFLDPSISPEFVVASEQFLSTMVPSGVYMRNASCHFQGIPSHNSSVSGALRVCNSYWSREHPKLQRAEDVDALLLGMASQIAEREDHVVVEDMQDFWPGPLKFSRTDYLASCLQRGRDLGLPSYTKAREALGLSPISHWQDINPALSRSNGTVLEATAALYNQDLSRLELLPGGLLESHGDPGPLFSTIVLDQFVRLRDGDRYWFENTRNGLFSKEEIAEIRNTSLRDILVAVTNVDPSALQPNVFFWLAGDPCPQPSQLSAKGLPACAPLFIRDYFEGSGFGFGLTIGTLCCFPLVSLLSAWIVARLRKRNFKRLQRQDRQSIMSEKLVGGVEALEWQGRNEPCRPVLVHLQPGQIRVVDGRLTVLRTIQLRPPQQVNLILSSNRGRRTLLLKIPKEYDLVLLFNMEEERQALVENVRGALKENGLSFQEWELREQELMRAAVTRQQRGHLLETFFRHLFSQVLDINQADAGTLPLDSSTKVREALTCELSRAEFADSLGLKPQDMFVESMFSLADKDGNGYLSFREFLDILVVFMKGSPEEKSRLMFRMYDFDGNGLISKDEFIRMLRSFIEISNNCLSKAQLAEVVESMFRESGFQDKEELTWEDFHFMLRDHDSDLRFTQLCVKGVEVPEVIKNLCRRASYISQEKICPSPRMSAHCARNNMKTASSPQRLQCPMDTDPPQEIRRRFGKKVTSFQPLLFTEAHREKFQRSRRHQTVQQFKRFIENYRRHIGCVAVFYTITGALFLERAYYYAFAAHHSGITDTTRVGIILSRGTAASISFMFSYILLTMCRNLITFLRETFLNRYIPFDAAVDFHRLIASTAIILTVLHSAGHVVNVYLFSISPLSVLSCLFPGLFHDDGSEFPQKYYWWFFQTVPGLTGVLLLLALAIMYVFASHHFRRRSFRGFWLTHHLYIFLYILLIIHGSFALIQMPRFHIFFLVPAIIYVGDKLVSLSRKKVEISVVKAELLPSGVTHLRFQRPQGFEYKSGQWVRIACLALGTTEYHPFTLTSAPHEDTLSLHIRAAGPWTTRLREIYSPPTGDTCARYPKLYLDGPFGEGHQEWHKFEVSVLVGGGIGVTPFASILKDLVFKSSVSCQVFCKKIYFIWVTRTQRQFEWLADIIREVEENDRQDLVSVHIYITQLAEKFDLRTTMLYICERHFQKVLNRSLFTGLRSITHFGRPPFEPFFNSLQEVHPQVRKIGVFSCGPPGMTKNVEKACQLINRQDRTHFSHHYENF", "length": 1551, "header": "tr|A2AQ92-1|A2AQ92_MOUSE Isoform 1 of NAD(P)H oxidase (H2O2-forming) OS=Mus musculus OX=10090 GN=Duox1 PE=1 SV=1 CANONICAL=A2AQ92-1" }, "isoforms": [ { "isoform_ac": "A2AQ92-1", "url": "https://www.uniprot.org/uniprotkb/A2AQ92/entry#A2AQ92-1", "sequence": { "sequence": "MGFHLALAWILLVGTLASLGAQNSISWEVQRFDGWYNNLMEHRWGSKGSRLQRLVPASYADGVYQPLKEPYLPNPRHLSNRVMRGSAGQPSLRNRTVLGVFFGYHVLSDLVSVETPGCPAEFLNIYIPHGDPVFDPDKRGNVVLPFQRSRWDRNTGQSPSNPRDQSNQVTGWLDGSAIYGSSHSWSDTLRSFSGGQLASGPDPAFPSDSQSSLLMWMAPDPSTGQGGPRGVYAFGAQRGNREPFLQALGLLWFRYHNLCARKLAQEHPHWGDEELFQHARKRVIATYQNIAMYEWLPSFLKQTPPEYPGYRPFLDPSISPEFVVASEQFLSTMVPSGVYMRNASCHFQGIPSHNSSVSGALRVCNSYWSREHPKLQRAEDVDALLLGMASQIAEREDHVVVEDMQDFWPGPLKFSRTDYLASCLQRGRDLGLPSYTKAREALGLSPISHWQDINPALSRSNGTVLEATAALYNQDLSRLELLPGGLLESHGDPGPLFSTIVLDQFVRLRDGDRYWFENTRNGLFSKEEIAEIRNTSLRDILVAVTNVDPSALQPNVFFWLAGDPCPQPSQLSAKGLPACAPLFIRDYFEGSGFGFGLTIGTLCCFPLVSLLSAWIVARLRKRNFKRLQRQDRQSIMSEKLVGGVEALEWQGRNEPCRPVLVHLQPGQIRVVDGRLTVLRTIQLRPPQQVNLILSSNRGRRTLLLKIPKEYDLVLLFNMEEERQALVENVRGALKENGLSFQEWELREQELMRAAVTRQQRGHLLETFFRHLFSQVLDINQADAGTLPLDSSTKVREALTCELSRAEFADSLGLKPQDMFVESMFSLADKDGNGYLSFREFLDILVVFMKGSPEEKSRLMFRMYDFDGNGLISKDEFIRMLRSFIEISNNCLSKAQLAEVVESMFRESGFQDKEELTWEDFHFMLRDHDSDLRFTQLCVKGVEVPEVIKNLCRRASYISQEKICPSPRMSAHCARNNMKTASSPQRLQCPMDTDPPQEIRRRFGKKVTSFQPLLFTEAHREKFQRSRRHQTVQQFKRFIENYRRHIGCVAVFYTITGALFLERAYYYAFAAHHSGITDTTRVGIILSRGTAASISFMFSYILLTMCRNLITFLRETFLNRYIPFDAAVDFHRLIASTAIILTVLHSAGHVVNVYLFSISPLSVLSCLFPGLFHDDGSEFPQKYYWWFFQTVPGLTGVLLLLALAIMYVFASHHFRRRSFRGFWLTHHLYIFLYILLIIHGSFALIQMPRFHIFFLVPAIIYVGDKLVSLSRKKVEISVVKAELLPSGVTHLRFQRPQGFEYKSGQWVRIACLALGTTEYHPFTLTSAPHEDTLSLHIRAAGPWTTRLREIYSPPTGDTCARYPKLYLDGPFGEGHQEWHKFEVSVLVGGGIGVTPFASILKDLVFKSSVSCQVFCKKIYFIWVTRTQRQFEWLADIIREVEENDRQDLVSVHIYITQLAEKFDLRTTMLYICERHFQKVLNRSLFTGLRSITHFGRPPFEPFFNSLQEVHPQVRKIGVFSCGPPGMTKNVEKACQLINRQDRTHFSHHYENF", "length": 1551, "header": "tr|A2AQ92-1|A2AQ92_MOUSE Isoform 1 of NAD(P)H oxidase (H2O2-forming) OS=Mus musculus OX=10090 GN=Duox1 PE=1 SV=1 CANONICAL=A2AQ92-1" }, "locus": { "chromosome": "2", "start_pos": 122177870, "end_pos": 122146184, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000099461.4", "url": "https://www.ensembl.org/id/ENSMUST00000099461.4" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000097060.4", "url": "https://www.ensembl.org/id/ENSMUSP00000097060.4" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 1092, "end_pos": 1092, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "A2AQ92", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2AQ92" } ], "site_lbl": "Ser1092" }, { "start_pos": 1094, "end_pos": 1094, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "A2AQ92", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2AQ92" } ], "site_lbl": "Ser1094" }, { "start_pos": 1099, "end_pos": 1099, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "A2AQ92", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2AQ92" } ], "site_lbl": "Tyr1099" }, { "start_pos": 1276, "end_pos": 1276, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "A2AQ92", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2AQ92" } ], "site_lbl": "Ser1276" }, { "start_pos": 199, "end_pos": 199, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "A2AQ92", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2AQ92" } ], "site_lbl": "Ser199" }, { "start_pos": 207, "end_pos": 207, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "A2AQ92", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2AQ92" } ], "site_lbl": "Ser207" }, { "start_pos": 209, "end_pos": 209, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "A2AQ92", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2AQ92" } ], "site_lbl": "Ser209" }, { "start_pos": 634, "end_pos": 634, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "A2AQ92", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2AQ92" } ], "site_lbl": "Ser634" }, { "start_pos": 955, "end_pos": 955, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "A2AQ92", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2AQ92" } ], "site_lbl": "Ser955" } ], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Duox1 is the main source of hydrogen peroxide in the rat thyroid cell line PCCl3.", "journal": "Experimental cell research", "date": "2007", "authors": "Rigutto S, Hoste C, Dumont JE, Corvilain B, Miot F, De Deken X", "evidence": [ { "database": "RefSeq", "id": "NP_001092767", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092767" } ], "reference": [ { "type": "PubMed", "id": "17643428", "url": "https://glygen.org/publication/PubMed/17643428" } ] }, { "title": "Structures of mouse DUOX1-DUOXA1 provide mechanistic insights into enzyme activation and regulation.", "journal": "Nat. Struct. Mol. Biol.", "date": "2020", "authors": "Sun J", "evidence": [ { "database": "UniProtKB", "id": "A2AQ92", "url": "https://www.uniprot.org/uniprot/A2AQ92" } ], "reference": [ { "type": "PubMed", "id": "32929281", "url": "https://glygen.org/publication/PubMed/32929281" } ] }, { "title": "Oxidation-Dependent Activation of Src Kinase Mediates Epithelial IL-33 Production and Signaling during Acute Airway Allergen Challenge.", "journal": "Journal of immunology (Baltimore, Md. : 1950)", "date": "2021", "authors": "Dustin CM, Habibovic A, Hristova M, Schiffers C, Morris CR, Lin MJ, Bauer RA, Heppner DE, Daphtary N, Aliyeva M, van der Vliet A", "evidence": [ { "database": "RefSeq", "id": "NP_001092767", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092767" } ], "reference": [ { "type": "PubMed", "id": "34088769", "url": "https://glygen.org/publication/PubMed/34088769" } ] }, { "title": "Dual oxidase 1 promotes antiviral innate immunity.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2021", "authors": "Sarr D, Gingerich AD, Asthiwi NM, Almutairi F, Sautto GA, Ecker J, Nagy T, Kilgore MB, Chandler JD, Ross TM, Tripp RA, Rada B", "evidence": [ { "database": "RefSeq", "id": "NP_001092767", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092767" } ], "reference": [ { "type": "PubMed", "id": "34168077", "url": "https://glygen.org/publication/PubMed/34168077" } ] }, { "title": "Diet-induced obesity worsens allergen-induced type 2/type 17 inflammation in airways by enhancing DUOX1 activation.", "journal": "American journal of physiology. Lung cellular and molecular physiology", "date": "2023-02-01", "authors": "Habibovic Aida, Hristova Milena, Morris Carolyn R, Lin Miao-Chong Joy, Cruz Litiele C, Ather Jennifer L, Geiszt Mikl\u00f3s, Anathy Vikas, Janssen-Heininger Yvonne M W, Poynter Matthew E, Dixon Anne E, van der Vliet Albert", "evidence": [ { "database": "RefSeq", "id": "NP_001092767", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092767" } ], "reference": [ { "type": "PubMed", "id": "36625485", "url": "https://glygen.org/publication/PubMed/36625485" } ] }, { "title": "Dual oxidase 1 is dispensable during Mycobacterium tuberculosis infection in mice.", "journal": "Frontiers in immunology", "date": "2023", "authors": "Gupta Tuhina, Sarr Demba, Fantone Kayla, Ashtiwi Nuha Milad, Sakamoto Kaori, Quinn Frederick D, Rada Bal\u00e1zs", "evidence": [ { "database": "RefSeq", "id": "NP_001092767", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092767" } ], "reference": [ { "type": "PubMed", "id": "36936954", "url": "https://glygen.org/publication/PubMed/36936954" } ] } ], "pathway": [ { "id": "mmu:99439", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:99439", "resource": "KEGG Pathway" }, { "id": "R-MMU-209968", "name": "Thyroxine biosynthesis", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-209968", "resource": "Reactome", "description": "Thyroxine biosynthesis" } ], "orthologs": [ { "uniprot_canonical_ac": "Q8CIY2-1", "protein_name": "Dual oxidase 1", "gene_name": "Duox1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAVYSAVAWILLFGVLASLGAQNPVSWEVQRFDGWYNNLMEHRWGSKGSRLQRLVPASYADGVYQPLREPYLPNPRHLSNRVMRGPAGQPSLRNRTVLGVFFGYHVLSDLVSVETPGCPAEFLNIYIPRGDPVFDPDKRGNVVLPFQRSRWDRSTGQSPSNPRDLTNQVTGWLDGSAIYGSSHSWSDTLRSFSGGQLASGPDPAFPRNSQNSLLMWMAPDPATGQGGPQGLYAFGAQRGNREPFLQALGLLWFRYHNLCAKRLAQEHPHWGDEELFQHARKRVIATYQNIAMYEWLPSFLKQTPPEYPGYHPFLDPSISPEFVVASEQFLSTMVPPGVYMRNASCHFQGIANRNSSVSGALRVCNSYWSRENPKLQRAEDVDALLLGMASQIAEREDHLVVEDVQDFWPGPLKFSRTDYLASCLQRGRDLGLPSYTKAREALGLPPVSHWQDINPALSRSNGTVLEATAALYNQDLSRLELLAGGLLESHGDPGPLFSAIVLDQFVRLRDGDRYWFENNRNGLFSKEEIAEIRNTSLRDILVAVTNVDPSALQPSVFFWLAGDPCPQPSQLSTQGLPACAPLFVRDYFKGSGFGFGLTIGTLCCFPLVSLLSAWIVARLRMRNFKRLQRQDRQSIMCEKLVGGVEALEWQGRKEPCRPVLVHLQPGQIRVVDGRLTVLRTIQLRPPQQVNLILSSNRGRRTLLLKIPKEYDLVLLFNMEEERQALVENIRAALKENGLSFQEWELREQELMRAAVTRQQRGHLLETFFRHLFSQVLDINQADAGTLPLDSSTKVREALTCELSRAEFADSLGLKPQDMFVESMFSLADKDGNGYLSFREFLDILVVFMKGSPEEKSRLMFRMYDFDGNGLISKDEFIRMLRSFIEISNNCLSKDQLAEVVESMFRESGFQDKEELTWEDFHFMLRDHDSDLRFTQLCVKGVEVPEVIKNLCRRASYISQEKICPSPRMSAHCARNNTKTASSPQRLQCPVDTDPPQEIRRRFGKKVTSFQPLLFTEAHREKFQRSRRHQTVQQFKRFIENYRRHIGCVAVFYTITGALFLERAYYYAFAAHHSGITDTTRVGIILSRGTAASISFMFSYILLTMCRNLITFLRETFLNRYIPFDAAVDFHRFIASTAIILTVLHSAGHVVNVYLFSISPLSVLSCLFPDLFHDDGSEFPQKYYWWFFQTVPGLTGVLLLLALAIMYVFASHHFRRRSFRGFWLTHHLYIFLYILLIIHGSFALIQMPRFHIFFLVPAIIYVGDKLVSLSRKKVEISVVKAELLPSGVTHLRFQRPQGFEYKSGQWVRIACLALGTTEYHPFTLTSAPHEDTLSLHIRAAGPWTTRLREIYSPPTGDTCARYPKLYLDGPFGEGHQEWHKFEVSVLVGAGIGVTPFASILKDLVFKSSVSCQVFCKKIYFIWVTRTQRQFEWLADIIREVEENDSRDLVSVHIYITQLAEKFDLRTTMLYICERHFQKVLNRSLFTGLRSVTHFGRPPFEPFFNSLQEVHPQVRKIGVFSCGPPGMTKNVEKACQLINKQDRTHFSHHYENF", "length": 1551 }, "evidence": [ { "id": "46370177", "url": "http://www.informatics.jax.org/homology/46370177", "database": "MGI" }, { "id": "A2AQ92", "url": "https://omabrowser.org/oma/group/A2AQ92/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9NRD9-1", "protein_name": "Dual oxidase 1", "gene_name": "DUOX1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGFCLALAWTLLVGAWTPLGAQNPISWEVQRFDGWYNNLMEHRWGSKGSRLQRLVPASYADGVYQPLGEPHLPNPRDLSNTISRGPAGLASLRNRTVLGVFFGYHVLSDLVSVETPGCPAEFLNIRIPPGDPMFDPDQRGDVVLPFQRSRWDPETGRSPSNPRDPANQVTGWLDGSAIYGSSHSWSDALRSFSRGQLASGPDPAFPRDSQNPLLMWAAPDPATGQNGPRGLYAFGAERGNREPFLQALGLLWFRYHNLWAQRLARQHPDWEDEELFQHARKRVIATYQNIAVYEWLPSFLQKTLPEYTGYRPFLDPSISSEFVAASEQFLSTMVPPGVYMRNASCHFQGVINRNSSVSRALRVCNSYWSREHPSLQSAEDVDALLLGMASQIAEREDHVLVEDVRDFWPGPLKFSRTDHLASCLQRGRDLGLPSYTKARAALGLSPITRWQDINPALSRSNDTVLEATAALYNQDLSWLELLPGGLLESHRDPGPLFSTIVLEQFVRLRDGDRYWFENTRNGLFSKKEIEEIRNTTLQDVLVAVINIDPSALQPNVFVWHKGDPCPQPRQLSTEGLPACAPSVVRDYFEGSGFGFGVTIGTLCCFPLVSLLSAWIVARLRMRNFKRLQGQDRQSIVSEKLVGGMEALEWQGHKEPCRPVLVYLQPGQIRVVDGRLTVLRTIQLQPPQKVNFVLSSNRGRRTLLLKIPKEYDLVLLFNLEEERQALVENLRGALKESGLSIQEWELREQELMRAAVTREQRRHLLETFFRHLFSQVLDINQADAGTLPLDSSQKVREALTCELSRAEFAESLGLKPQDMFVESMFSLADKDGNGYLSFREFLDILVVFMKGSPEEKSRLMFRMYDFDGNGLISKDEFIRMLRSFIEISNNCLSKAQLAEVVESMFRESGFQDKEELTWEDFHFMLRDHNSELRFTQLCVKGVEVPEVIKDLCRRASYISQDMICPSPRVSARCSRSDIETELTPQRLQCPMDTDPPQEIRRRFGKKVTSFQPLLFTEAHREKFQRSCLHQTVQQFKRFIENYRRHIGCVAVFYAIAGGLFLERAYYYAFAAHHTGITDTTRVGIILSRGTAASISFMFSYILLTMCRNLITFLRETFLNRYVPFDAAVDFHRLIASTAIVLTVLHSVGHVVNVYLFSISPLSVLSCLFPGLFHDDGSELPQKYYWWFFQTVPGLTGVVLLLILAIMYVFASHHFRRRSFRGFWLTHHLYILLYVLLIIHGSFALIQLPRFHIFFLVPAIIYGGDKLVSLSRKKVEISVVKAELLPSGVTHLRFQRPQGFEYKSGQWVRIACLALGTTEYHPFTLTSAPHEDTLSLHIRAAGPWTTRLREIYSAPTGDRCARYPKLYLDGPFGEGHQEWHKFEVSVLVGGGIGVTPFASILKDLVFKSSVSCQVFCKKIYFIWVTRTQRQFEWLADIIREVEENDHQDLVSVHIYITQLAEKFDLRTTMLYICERHFQKVLNRSLFTGLRSITHFGRPPFEPFFNSLQEVHPQVRKIGVFSCGPPGMTKNVEKACQLINRQDRTHFSHHYENF", "length": 1551 }, "evidence": [ { "id": "46370177", "url": "http://www.informatics.jax.org/homology/46370177", "database": "MGI" }, { "id": "A2AQ92", "url": "https://omabrowser.org/oma/group/A2AQ92/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9VQH2-1", "protein_name": "Dual oxidase", "gene_name": "Duox", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MSVPSAPHQRAESKNRVPRPGQKNRKLPKLRLHWPGATYGGALLLLLISYGLELGSVHCYEKMYSQTEKQRYDGWYNNLAHPDWGSVDSHLVRKAPPSYSDGVYAMAGANRPSTRRLSRLFMRGKDGLGSKFNRTALLAFFGQLVANEIVMASESGCPIEMHRIEIEKCDEMYDRECRGDKYIPFHRAAYDRDTGQSPNAPREQINQMTAWIDGSFIYSTSEAWLNAMRSFHNGTLLTEKDGKLPVRNTMRVPLFNNPVPSVMKMLSPERLFLLGDPRTNQNPAILSFAILFLRWHNTLAQRIKRVHPDWSDEDIYQRARHTVIASLQNVIVYEYLPAFLGTSLPPYEGYKQDIHPGIGHIFQAAAFRFGHTMIPPGIYRRDGQCNFKETPMGYPAVRLCSTWWDSSGFFADTSVEEVLMGLASQISEREDPVLCSDVRDKLFGPMEFTRRDLGALNIMRGRDNGLPDYNTARESYGLKRHKTWTDINPPLFETQPELLDMLKEAYDNKLDDVDVYVGGMLESYGQPGEFFTAVIKEQFQRLRDADRFWFENERNGIFTPEEIAELRKITLWDIIVNSTDVKEEEIQKDVFMWRTGDPCPQPMQLNATELEPCTYLEGYDYFSGSELMFIYVCVFLGFVPILCAGAGYCVVKLQNSKRRRLKIRQEALRAPQHKGSVDKMLAREWLHANHKRLVTVKFGPEAAIYTVDRKGEKLRTFSLKHIDVVSVEESATNHIKKKPYILLRVPSDHDLVLELESYGARRKFVKKLEDFLLLHKKEMTLMEVNRDIMLARAETRERRQKRLEYFFREAYALTFGLRPGERRRRSDASSDGEVMTVMRTSLSKAEFAAALGMKPNDMFVRKMFNIVDKDQDGRISFQEFLETVVLFSRGKTDDKLRIIFDMCDNDRNGVIDKGELSEMMRSLVEIARTTSLGDDQVTELIDGMFQDVGLEHKNHLTYQDFKLMMKEYKGDFVAIGLDCKGAKQNFLDTSTNVARMTSFNIEPMQDKPRHWLLAKWDAYITFLEENRQNIFYLFLFYVVTIVLFVERFIHYSFMAEHTDLRHIMGVGIAITRGSAASLSFCYSLLLLTMSRNLITKLKEFPIQQYIPLDSHIQFHKIAACTALFFSVLHTVGHIVNFYHVSTQSHENLRCLTREVHFASDYKPDITFWLFQTVTGTTGVMLFIIMCIIFVFAHPTIRKKAYNFFWNMHTLYIGLYLLSLIHGLARLTGPPRFWMFFLGPGIVYTLDKIVSLRTKYMALDVIDTDLLPSDVIKIKFYRPPNLKYLSGQWVRLSCTAFRPHEMHSFTLTSAPHENFLSCHIKAQGPWTWKLRNYFDPCNYNPEDQPKIRIEGPFGGGNQDWYKFEVAVMVGGGIGVTPYASILNDLVFGTSTNRYSGVACKKVYFLWICPSHKHFEWFIDVLRDVEKKDVTNVLEIHIFITQFFHKFDLRTTMLYICENHFQRLSKTSIFTGLKAVNHFGRPDMSSFLKFVQKKHSYVSKIGVFSCGPRPLTKSVMSACDEVNKTRKLPYFIHHFENFG", "length": 1537 }, "evidence": [ { "id": "A2AQ92", "url": "https://omabrowser.org/oma/group/A2AQ92/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 6, "go_terms": [ { "name": "NADPH oxidase complex", "id": "GO:0043020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043020", "evidence": [ { "database": "UniProtKB", "id": "A2AQ92", "url": "https://www.uniprot.org/uniprot/A2AQ92" } ], "pmid": "" }, { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "A2AQ92", "url": "https://www.uniprot.org/uniprot/A2AQ92" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A2AQ92", "url": "https://www.uniprot.org/uniprot/A2AQ92" } ], "pmid": "" }, { "name": "cell surface", "id": "GO:0009986", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009986", "evidence": [ { "database": "UniProtKB", "id": "A2AQ92", "url": "https://www.uniprot.org/uniprot/A2AQ92" } ], "pmid": "" }, { "name": "cell leading edge", "id": "GO:0031252", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031252", "evidence": [ { "database": "UniProtKB", "id": "A2AQ92", "url": "https://www.uniprot.org/uniprot/A2AQ92" } ], "pmid": "" }, { "name": "apical plasma membrane", "id": "GO:0016324", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016324", "evidence": [ { "database": "UniProtKB", "id": "A2AQ92", "url": "https://www.uniprot.org/uniprot/A2AQ92" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 13, "go_terms": [ { "name": "cuticle development", "id": "GO:0042335", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042335", "evidence": [ { "database": "UniProtKB", "id": "A2AQ92", "url": "https://www.uniprot.org/uniprot/A2AQ92" } ], "pmid": "" }, { "name": "defense response", "id": "GO:0006952", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006952", "evidence": [ { "database": "UniProtKB", "id": "A2AQ92", "url": "https://www.uniprot.org/uniprot/A2AQ92" } ], "pmid": "" }, { "name": "response to oxidative stress", "id": "GO:0006979", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006979", "evidence": [ { "database": "UniProtKB", "id": "A2AQ92", "url": "https://www.uniprot.org/uniprot/A2AQ92" } ], "pmid": "" }, { "name": "positive regulation of wound healing", "id": "GO:0090303", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090303", "evidence": [ { "database": "UniProtKB", "id": "A2AQ92", "url": "https://www.uniprot.org/uniprot/A2AQ92" } ], "pmid": "" }, { "name": "hormone biosynthetic process", "id": "GO:0042446", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042446", "evidence": [ { "database": "UniProtKB", "id": "A2AQ92", "url": "https://www.uniprot.org/uniprot/A2AQ92" } ], "pmid": "" }, { "name": "hydrogen peroxide biosynthetic process", "id": "GO:0050665", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050665", "evidence": [ { "database": "UniProtKB", "id": "A2AQ92", "url": "https://www.uniprot.org/uniprot/A2AQ92" } ], "pmid": "" }, { "name": "hydrogen peroxide catabolic process", "id": "GO:0042744", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042744", "evidence": [ { "database": "UniProtKB", "id": "A2AQ92", "url": "https://www.uniprot.org/uniprot/A2AQ92" } ], "pmid": "" }, { "name": "response to cAMP", "id": "GO:0051591", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051591", "evidence": [ { "database": "UniProtKB", "id": "A2AQ92", "url": "https://www.uniprot.org/uniprot/A2AQ92" } ], "pmid": "" }, { "name": "reactive oxygen species metabolic process", "id": "GO:0072593", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072593", "evidence": [ { "database": "UniProtKB", "id": "A2AQ92", "url": "https://www.uniprot.org/uniprot/A2AQ92" } ], "pmid": "" }, { "name": "positive regulation of cell motility", "id": "GO:2000147", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000147", "evidence": [ { "database": "UniProtKB", "id": "A2AQ92", "url": "https://www.uniprot.org/uniprot/A2AQ92" } ], "pmid": "" }, { "name": "cytokine-mediated signaling pathway", "id": "GO:0019221", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019221", "evidence": [ { "database": "UniProtKB", "id": "A2AQ92", "url": "https://www.uniprot.org/uniprot/A2AQ92" } ], "pmid": "" }, { "name": "thyroid hormone generation", "id": "GO:0006590", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006590", "evidence": [ { "database": "UniProtKB", "id": "A2AQ92", "url": "https://www.uniprot.org/uniprot/A2AQ92" } ], "pmid": "" }, { "name": "superoxide anion generation", "id": "GO:0042554", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042554", "evidence": [ { "database": "UniProtKB", "id": "A2AQ92", "url": "https://www.uniprot.org/uniprot/A2AQ92" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "A2AQ92", "url": "https://www.uniprot.org/uniprot/A2AQ92" } ], "pmid": "" }, { "name": "heme binding", "id": "GO:0020037", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0020037", "evidence": [ { "database": "UniProtKB", "id": "A2AQ92", "url": "https://www.uniprot.org/uniprot/A2AQ92" } ], "pmid": "" }, { "name": "NAD(P)H oxidase H2O2-forming activity", "id": "GO:0016174", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016174", "evidence": [ { "database": "UniProtKB", "id": "A2AQ92", "url": "https://www.uniprot.org/uniprot/A2AQ92" } ], "pmid": "" }, { "name": "peroxidase activity", "id": "GO:0004601", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004601", "evidence": [ { "database": "UniProtKB", "id": "A2AQ92", "url": "https://www.uniprot.org/uniprot/A2AQ92" } ], "pmid": "" }, { "name": "superoxide-generating NAD(P)H oxidase activity", "id": "GO:0016175", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016175", "evidence": [ { "database": "UniProtKB", "id": "A2AQ92", "url": "https://www.uniprot.org/uniprot/A2AQ92" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1480, "end_pos": 1482, "annotation": "n_glycosylation_sequon" }, { "start_pos": 342, "end_pos": 344, "annotation": "n_glycosylation_sequon" }, { "start_pos": 354, "end_pos": 356, "annotation": "n_glycosylation_sequon" }, { "start_pos": 461, "end_pos": 463, "annotation": "n_glycosylation_sequon" }, { "start_pos": 534, "end_pos": 536, "annotation": "n_glycosylation_sequon" }, { "start_pos": 94, "end_pos": 96, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "11260", "name": "", "equation": "H(+) + NADPH + O2 = H2O2 + NADP(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A2AQ92-1", "P97872-1", "Q8C116-1", "A0A494BAW1-1", "B2RWH8-1", "Q8VDP3-1", "Q9JHI8-1" ], "evidence": [ { "id": "11260", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/11260" } ] }, { "id": "11264", "name": "", "equation": "H(+) + NADH + O2 = H2O2 + NAD(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A2AQ92-1", "A0A494BAW1-1" ], "evidence": [ { "id": "11264", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/11264" } ] }, { "id": "R-MMU-5693681", "name": "DUOX1,2 reduce O2 to H2O2", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A2AQ92-1", "A0A494BAW1-1" ], "evidence": [ { "id": "R-MMU-5693681", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-5693681" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A494BAW1", "gene_name": "Duox2", "activity": [ { "ec_number": "1.6.3.1", "activity": "H(+) + NADH + O2 = H2O2 + NAD(+).", "evidence": [ { "id": "A0A494BAW1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A494BAW1" } ] }, { "ec_number": "1.6.3.1", "activity": "", "evidence": [ { "id": "A0A494BAW1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A494BAW1" } ] } ] }, { "uniprot_ac": "A2AQ92", "gene_name": "Duox1", "activity": [ { "ec_number": "1.6.3.1", "activity": "H(+) + NADH + O2 = H2O2 + NAD(+).", "evidence": [ { "id": "A2AQ92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2AQ92" } ] }, { "ec_number": "1.6.3.1", "activity": "", "evidence": [ { "id": "A2AQ92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2AQ92" } ] } ] }, { "uniprot_ac": "B2RWH8", "gene_name": "Gm4846", "activity": [ { "ec_number": "1.-.-.-", "activity": "", "evidence": [ { "id": "B2RWH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B2RWH8" } ] } ] }, { "uniprot_ac": "P97872", "gene_name": "Fmo5", "activity": [ { "ec_number": "1.6.3.1", "activity": "H(+) + NADH + O2 = H2O2 + NAD(+).", "evidence": [ { "id": "P97872", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97872" } ] }, { "ec_number": "1.14.13.8", "activity": "H(+) + N,N-dimethylaniline + NADPH + O2 = H2O + N,N-dimethylaniline N-oxide + NADP(+).", "evidence": [ { "id": "P97872", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97872" } ] } ] }, { "uniprot_ac": "Q8C116", "gene_name": "Fmo9", "activity": [ { "ec_number": "1.-.-.-", "activity": "", "evidence": [ { "id": "Q8C116", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8C116" } ] } ] }, { "uniprot_ac": "Q8VDP3", "gene_name": "Mical1", "activity": [ { "ec_number": "1.6.3.1", "activity": "H(+) + NADH + O2 = H2O2 + NAD(+).", "evidence": [ { "id": "Q8VDP3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VDP3" } ] }, { "ec_number": "1.14.13.225", "activity": "H(+) + L-methionyl-[F-actin] + NADPH + O2 = H2O + L-methionyl-(R)-S-oxide-[F-actin] + NADP(+).", "evidence": [ { "id": "Q8VDP3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VDP3" } ] }, { "ec_number": "1.14.13.225", "activity": "", "evidence": [ { "id": "Q8VDP3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VDP3" } ] }, { "ec_number": "1.6.3.1", "activity": "", "evidence": [ { "id": "Q8VDP3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VDP3" } ] } ] }, { "uniprot_ac": "Q9JHI8", "gene_name": "Nox4", "activity": [ { "ec_number": "1.6.3.1", "activity": "H(+) + NADH + O2 = H2O2 + NAD(+).", "evidence": [ { "id": "Q9JHI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9JHI8" } ] }, { "ec_number": "1.6.3.1", "activity": "", "evidence": [ { "id": "Q9JHI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9JHI8" } ] } ] } ], "biomarkers": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "1.6.3.1", "ec_name": "H(+) + NADH + O2 = H2O2 + NAD(+).", "evidence": [ { "id": "1.6.3.1", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.3.1" }, { "id": "1.6.3.1", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=1.6.3.1" } ] } ], "cluster_types": [ { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 199, 207, 209, 634, 955, 1092, 1094, 1099, 1276 ], "sequon_annotation_sites": [ { "start_pos": 1480, "end_pos": 1482 }, { "start_pos": 342, "end_pos": 344 }, { "start_pos": 354, "end_pos": 356 }, { "start_pos": 461, "end_pos": 463 }, { "start_pos": 534, "end_pos": 536 }, { "start_pos": 94, "end_pos": 96 } ] }, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": 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"journal", "date", "authors" ] } ] }