{ "uniprot_canonical_ac": "A2AQ25-1", "uniprot_ac": "A2AQ25", "uniprot_id": "SKT_MOUSE", "mass": { "chemical_mass": 213037.0, "monoisotopic_mass": 213037.0 }, "refseq": { "ac": "NP_001074475", "name": "sickle tail protein isoform c", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074475" }, "gene_names": [ { "name": "Etl4", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A2AQ25", "id": "A2AQ25" }, { "name": "Skt", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A2AQ25", "id": "A2AQ25" }, { "name": "6620402G01Rik; 9430077C05Rik; E330027G05Rik; Etl-4; Skt", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074475", "id": "NP_001074475" }, { "name": "BC026657", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A2AQ25", "id": "A2AQ25" }, { "name": "Etl4", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074475", "id": "NP_001074475" }, { "name": "Etl4", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A2AQ25", "id": "A2AQ25" }, { "name": "Kiaa1217", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A2AQ25", "id": "A2AQ25" } ], "protein_names": [ { "name": "Sickle tail protein", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprotkb/A2AQ25/entry#names_and_taxonomy", "id": "A2AQ25" }, { "name": "Enhancer trap locus 4", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A2AQ25/entry#names_and_taxonomy", "id": "A2AQ25" }, { "name": "sickle tail protein isoform c", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074475", "id": "NP_001074475" }, { "name": "sickle tail protein", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074475", "id": "NP_001074475" } ], "function": [ { "annotation": "A Genetic Screen Identifies Etl4-Deficiency Capable of Stabilizing the Haploidy in Embryonic Stem Cells.", "evidence": [ { "database": "RefSeq", "id": "NP_001074475", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074475" }, { "database": "PubMed", "id": "33440180", "url": "https://glygen.org/publication/PubMed/33440180" } ] }, { "annotation": "Required for normal development of intervertebral disks.", "evidence": [ { "database": "UniProtKB", "id": "A2AQ25", "url": "https://www.uniprot.org/uniprot/A2AQ25#function" }, { "database": "PubMed", "id": "16204209", "url": "https://glygen.org/publication/PubMed/16204209" } ] }, { "annotation": "Study deleted 868 kb of genomic DNA encompassing nearly the whole coding region of Skt/Etl4. Surprisingly, mice homozygous for this deletion were viable and fertile. Despite expression of Skt/Etl4 in multiple tissues during embryonic development the deletion caused only mild malformations of the axial skeleton. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001074475", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074475" }, { "database": "PubMed", "id": "26678520", "url": "https://glygen.org/publication/PubMed/26678520" } ] } ], "disease": [], "snv": [ { "evidence": [ { "id": "rs3388528898", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs3388528898" } ], "glycoeffect": [ "o-glyco-site-loss" ], "start_pos": 1096, "end_pos": 1096, "sequence_org": "T", "sequence_mut": "I", "comment": "Germline mutation passed 1 out of 1 filters: o-glyco-site-loss (T->I).", "chr_id": "2", "chr_pos": "20803461", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "T1096", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs3388528493", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs3388528493" } ], "glycoeffect": [ "n-glyco-sequon-gain", "o-glyco-site-loss" ], "start_pos": 1269, "end_pos": 1269, "sequence_org": "S", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (SFS->NFS).", "chr_id": "2", "chr_pos": "20810773", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "S1269", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs3388531710", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs3388531710" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 378, "end_pos": 378, "sequence_org": "D", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (DMS->NMS).", "chr_id": "2", "chr_pos": "20748555", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "D378", "keywords": [ "ebi", "germline" ] } ], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "A2AQ25", "url": "https://www.uniprot.org/uniprot/A2AQ25" } ], "common_name": "Mouse", "glygen_name": "Mouse", "reference_species": "Mus musculus [10090]" } ], "gene": [ { "name": "Skt", "url": "https://www.uniprot.org/uniprot/A2AQ25", "locus": {} } ], "crossref": [ { "id": "ENSMUSG00000036617", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000036617", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "208618", "url": "https://www.ncbi.nlm.nih.gov/gene/208618", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "A2AQ25", "url": "https://www.ebi.ac.uk/intact/interactors/id:A2AQ25*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR022782", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022782", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "mmu:208618", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:208618", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "95454", "url": "http://www.informatics.jax.org/marker/MGI:95454", "database": "MGI", "categories": [ "Organism-specific" ] }, { "id": "A2AQ25", "url": "https://oglcnac.org/atlas/detail/A2AQ25", "database": "O-GlcNAc Atlas", "categories": [ "Glycoproteomics" ] }, { "id": "A2AQ25", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=A2AQ25", "database": "O-GlcNAc Database", "categories": [ "Glycoproteomics" ] }, { "id": "YELNDVX", "url": "https://omabrowser.org/oma/group/YELNDVX/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR22741", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22741", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22741:SF11", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22741:SF11", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03915", "url": "http://pfam.xfam.org/family/PF03915", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_A2AQ25", "url": "http://purl.obolibrary.org/obo/PR_A2AQ25", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_001074475", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074475", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A5F8MPV1", "url": "https://www.uniprot.org/uniprot/A0A5F8MPV1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A5F8MPV1-1", "url": "https://www.uniprot.org/uniprot/A0A5F8MPV1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A2AQ25", "url": "https://www.uniprot.org/uniprot/A2AQ25", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A2AQ25-1", "url": "https://www.uniprot.org/uniprot/A2AQ25-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A2AQ25-2", "url": "https://www.uniprot.org/uniprot/A2AQ25-2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A2AQ25-3", "url": "https://www.uniprot.org/uniprot/A2AQ25-3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A2AQ25-4", "url": "https://www.uniprot.org/uniprot/A2AQ25-4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A2AQ25-5", "url": "https://www.uniprot.org/uniprot/A2AQ25-5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A2AQ25-6", "url": "https://www.uniprot.org/uniprot/A2AQ25-6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A2AQ25-7", "url": "https://www.uniprot.org/uniprot/A2AQ25-7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A2AQ25-8", "url": "https://www.uniprot.org/uniprot/A2AQ25-8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A2AQ25-9", "url": "https://www.uniprot.org/uniprot/A2AQ25-9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "B1AY49", "url": "https://www.uniprot.org/uniprot/B1AY49", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "B1AY49-1", "url": "https://www.uniprot.org/uniprot/B1AY49-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "B1AY50", "url": "https://www.uniprot.org/uniprot/B1AY50", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "B1AY50-1", "url": "https://www.uniprot.org/uniprot/B1AY50-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "D3Z781", "url": "https://www.uniprot.org/uniprot/D3Z781", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "D3Z781-1", "url": "https://www.uniprot.org/uniprot/D3Z781-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E9QAU4", "url": "https://www.uniprot.org/uniprot/E9QAU4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E9QAU4-1", "url": "https://www.uniprot.org/uniprot/E9QAU4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q8BHR1", "url": "https://www.uniprot.org/uniprot/Q8BHR1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q8BHR1-1", "url": "https://www.uniprot.org/uniprot/Q8BHR1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEESEGQKCEPNLPPSGDSRQMPQQGRSNLHVTSQEDAACRRPRERLSNGNARAQVSKPARNIPRRHTLGGPRSSKEILGMQPSEMDRKREAFLEHLKQKYPHHATAIMGHQERLRDQTKSPKLSHSPQPPNLGDPVEHLSETSGDSLEAMSEGEVPSPFARGSRTRASLPVVRSANQTKERSLGVLYLQYGDETKQLRMPNEVTSTDTIRALFVSAFPQQLTMKMLESPSVAIYIKDDSRNVYYELNDVRNIQDRSLLKVYNKDPSHAFNHMTKAVNGDMRMQREIVYARGDGLVAPRPGSVAHPPHVIPNSPPSTPVPHSLPPSPSRIPYGGSRPMAIPGNATIPRDRLSSLPVSRSISPSPSAILERRDVKPDEDMSSKNLVMFRNEGFYADPYLYHEGRMSIASSHGGHPLDVPDHVIAYHRTAIRSASAYCSPSLQAEMHMEQSLYRQKSRKYPDSHLPTLGSKTPPASPHRVGDLRMIDLHPHLNTHGPPHTLQPDRASPSRQSFKKEPGTLVYIEKPRNTSGLSSLVDLGPPLVEKQGFAYSTTTIPKDRETRERMQAMEKQIASLTGLVQSALFKGPITSSSKEASSEKMVKATANRNQADGAGTAHVSAGKVLGSVEFSLPPSQPLPAGTSPIHTSLLDMRRNVAELRLQLQQMRQLQLQNQEILRAMMKKAELEISNKVKETMKRLEDPVQRQRTLVEQERQKYLHEEERIVKKLCELEDFVEDLKKDSSSTGRVVTLKDVEDGAFLLRQVGEAVATLKGEFPTLQNKMRAVLRIEVEAVRFLKEEPHKLDSLLKRVRSMTDVLTMLRRHVTDGLLKGTDASQAAQYVAMEKATAAEVLKHQEETAHAPGQPLHCSTGSPGDVKSEVVPLSTMTVHHVQSSPVVMQPSQHSSALMNPAQNLPGGTRPHTASPPAITQEVTSAQSAPGPQSPQTPVNGSSMQSLFIEEIHSVSAKNRAVSIEKAEKKWEEKRQNLEHYNGKEFEKLLEEAQANIMKSIPNLEMPPASSPVSKGDAAGDKLELSEDSPNSEQELDKIGGKSPPPPPPPPRRSYLPGSGLTTTRSGDVVYTGRSMSKVSSEDPGPTPQTRATKCPPEEPASAWAPSPPPVPAPSSKEEEEEEEEGDKIMAELQAFQKCSFMDVNPNSHAEQSRANSHLKDTRAGATAPPKEKKNLEFYHEDVRKSDVECENGPQVESQKVTAGALRPSGPPKWERVMVDSISDTSRTSECRADTFTEENATPNKSLFRDSRNYSQKNVPKVSFSSSGLNSLEGEINKGPNVSGLQCAIPDLENQKLNFGKTKEIGQQGQENADKSHIPLPTRSAEFSIHDVKTQDQDVPVTGYGQVVLRSKVGRHANMNMNEDGESTPSSPSEEHTATDNIAFMITKTAVQVLSSGEVHDIVSQKGQDVQTVNIDGRKETASQHEGTEGEEPVVCLDKKPVIIIFDEPMDIRSAYKRLSTIFEECDEELERMLTEEKIEEEEEDENEDSGVRTSSQMSCEQVDSRSDRMGQKAETQSQPHVLSAELLTPGVQGVRKAEQRKLSSADSPDSGNKCGMVDDQFESPKKKFKFKFPKKQLAALTQAIRTGTKTGKKTLQVVVYEEEEEDGTLKQHKEAKRFEITRSQPEDALKTMARRQEQLSPEGTLPASRTDEIRKSTYRTLDSLEQTIKQLENTISEMSPRALVDTSCSSNRDCGASLPHMAQEVSPRSLLVLDEVPPAPEPPTSISPASRKGSSTTPQTSRMPVPMTSKNRPGSLDKASKQSKLQDPRQYRQANGSAKKAGGDCKPTSPSLPASKIPALSPSSGKSSSLPSASGDSSNLPNAPATKPSIASTPLSPQAGRSAHSASLIPSVSNGSLKFQSPPHAGKGHHHLSFALQTQNGRAAPTTSSSSSPPSPASPTSLNQGARGIRTIHTPSLASYKAQNGSSSKATPSTAKETS", "length": 1946, "header": "sp|A2AQ25-1|SKT_MOUSE Isoform 1 of Sickle tail protein OS=Mus musculus OX=10090 GN=Skt PE=1 SV=1 CANONICAL=A2AQ25-1" }, "isoforms": [ { "isoform_ac": "A0A5F8MPV1-1", "url": "https://www.uniprot.org/uniprotkb/A2AQ25/entry#A0A5F8MPV1-1", "sequence": { "sequence": "MEESEGQKCEPNLPPSGDSRQMPQQGRSNLHVTSQEDAACRRPRERLSNGNARAQVSKPARNIPRRHTLGGPRSSKEILGMQPSEMDRKREAFLEHLKQKYPHHATAIMGHQERLRDQALQCMLVSLQAELDIQRYLMKIESSQRTKSPKLSHSPQPPNLGDPVEHLSETSGDSLEAMSEGEVPSPFARGSRTRASLPVVRSANQTKERSLGVLYLQYGDETKQLRMPNEVTSTDTIRALFVSAFPQQLTMKMLESPSVAIYIKDDSRNVYYELNDV", "length": 277, "header": "tr|A0A5F8MPV1-1|SKT_MOUSE Computationally mapped isoform of Sickle tail protein OS=Mus musculus OX=10090 GN=Skt PE=1 SV=1 CANONICAL=A2AQ25-1" }, "locus": { "chromosome": "2", "start_pos": 20714412, "end_pos": 20524669, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000238889.2", "url": "https://www.ensembl.org/id/ENSMUST00000238889.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000159127.2", "url": "https://www.ensembl.org/id/ENSMUSP00000159127.2" } ] } }, { "isoform_ac": "A2AQ25-1", "url": "https://www.uniprot.org/uniprotkb/A2AQ25/entry#A2AQ25-1", "sequence": { "sequence": "MEESEGQKCEPNLPPSGDSRQMPQQGRSNLHVTSQEDAACRRPRERLSNGNARAQVSKPARNIPRRHTLGGPRSSKEILGMQPSEMDRKREAFLEHLKQKYPHHATAIMGHQERLRDQTKSPKLSHSPQPPNLGDPVEHLSETSGDSLEAMSEGEVPSPFARGSRTRASLPVVRSANQTKERSLGVLYLQYGDETKQLRMPNEVTSTDTIRALFVSAFPQQLTMKMLESPSVAIYIKDDSRNVYYELNDVRNIQDRSLLKVYNKDPSHAFNHMTKAVNGDMRMQREIVYARGDGLVAPRPGSVAHPPHVIPNSPPSTPVPHSLPPSPSRIPYGGSRPMAIPGNATIPRDRLSSLPVSRSISPSPSAILERRDVKPDEDMSSKNLVMFRNEGFYADPYLYHEGRMSIASSHGGHPLDVPDHVIAYHRTAIRSASAYCSPSLQAEMHMEQSLYRQKSRKYPDSHLPTLGSKTPPASPHRVGDLRMIDLHPHLNTHGPPHTLQPDRASPSRQSFKKEPGTLVYIEKPRNTSGLSSLVDLGPPLVEKQGFAYSTTTIPKDRETRERMQAMEKQIASLTGLVQSALFKGPITSSSKEASSEKMVKATANRNQADGAGTAHVSAGKVLGSVEFSLPPSQPLPAGTSPIHTSLLDMRRNVAELRLQLQQMRQLQLQNQEILRAMMKKAELEISNKVKETMKRLEDPVQRQRTLVEQERQKYLHEEERIVKKLCELEDFVEDLKKDSSSTGRVVTLKDVEDGAFLLRQVGEAVATLKGEFPTLQNKMRAVLRIEVEAVRFLKEEPHKLDSLLKRVRSMTDVLTMLRRHVTDGLLKGTDASQAAQYVAMEKATAAEVLKHQEETAHAPGQPLHCSTGSPGDVKSEVVPLSTMTVHHVQSSPVVMQPSQHSSALMNPAQNLPGGTRPHTASPPAITQEVTSAQSAPGPQSPQTPVNGSSMQSLFIEEIHSVSAKNRAVSIEKAEKKWEEKRQNLEHYNGKEFEKLLEEAQANIMKSIPNLEMPPASSPVSKGDAAGDKLELSEDSPNSEQELDKIGGKSPPPPPPPPRRSYLPGSGLTTTRSGDVVYTGRSMSKVSSEDPGPTPQTRATKCPPEEPASAWAPSPPPVPAPSSKEEEEEEEEGDKIMAELQAFQKCSFMDVNPNSHAEQSRANSHLKDTRAGATAPPKEKKNLEFYHEDVRKSDVECENGPQVESQKVTAGALRPSGPPKWERVMVDSISDTSRTSECRADTFTEENATPNKSLFRDSRNYSQKNVPKVSFSSSGLNSLEGEINKGPNVSGLQCAIPDLENQKLNFGKTKEIGQQGQENADKSHIPLPTRSAEFSIHDVKTQDQDVPVTGYGQVVLRSKVGRHANMNMNEDGESTPSSPSEEHTATDNIAFMITKTAVQVLSSGEVHDIVSQKGQDVQTVNIDGRKETASQHEGTEGEEPVVCLDKKPVIIIFDEPMDIRSAYKRLSTIFEECDEELERMLTEEKIEEEEEDENEDSGVRTSSQMSCEQVDSRSDRMGQKAETQSQPHVLSAELLTPGVQGVRKAEQRKLSSADSPDSGNKCGMVDDQFESPKKKFKFKFPKKQLAALTQAIRTGTKTGKKTLQVVVYEEEEEDGTLKQHKEAKRFEITRSQPEDALKTMARRQEQLSPEGTLPASRTDEIRKSTYRTLDSLEQTIKQLENTISEMSPRALVDTSCSSNRDCGASLPHMAQEVSPRSLLVLDEVPPAPEPPTSISPASRKGSSTTPQTSRMPVPMTSKNRPGSLDKASKQSKLQDPRQYRQANGSAKKAGGDCKPTSPSLPASKIPALSPSSGKSSSLPSASGDSSNLPNAPATKPSIASTPLSPQAGRSAHSASLIPSVSNGSLKFQSPPHAGKGHHHLSFALQTQNGRAAPTTSSSSSPPSPASPTSLNQGARGIRTIHTPSLASYKAQNGSSSKATPSTAKETS", "length": 1946, "header": "sp|A2AQ25-1|SKT_MOUSE Isoform 1 of Sickle tail protein OS=Mus musculus OX=10090 GN=Skt PE=1 SV=1 CANONICAL=A2AQ25-1" }, "locus": { "chromosome": "2", "start_pos": 20814018, "end_pos": 20524669, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000066509.10", "url": "https://www.ensembl.org/id/ENSMUST00000066509.10" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000066170.4", "url": "https://www.ensembl.org/id/ENSMUSP00000066170.4" } ] } }, { "isoform_ac": "A2AQ25-2", "url": "https://www.uniprot.org/uniprotkb/A2AQ25/entry#A2AQ25-2", "sequence": { "sequence": "MQREIVYARGDGLVAPRPGSVAHPPHVIPNSPPSTPVPHSLPPSPSRIPYGGSRPMAIPGNATIPRDRLSSLPVSRSISPSPSAILERRDVKPDEDMSSKNLVMFRNEGFYADPYLYHEGRMSIASSHGGHPLDVPDHVIAYHRTAIRSASAYCSPSLQAEMHMEQSLYRQKSRKYPDSHLPTLGSKTPPASPHRVGDLRMIDLHPHLNTHGPPHTLQPDRASPSRQSFKKEPGTLVYIEKPRNTSGLSSLVDLGPPLVEKQGFAYSTTTIPKDRETSEKMVKATANRNQADGAGTAHVSAGKVLGSVEFSLPPSQPLPAGTSPIHTSLLDMRRNVAELRLQLQQMRQLQLQNQEILRAMMKKAELEISNKVKETMKRLEDPVQRQRTLVEQERQKYLHEEERIVKKLCELEDFVEDLKKDSSSTGRVVTLKDVEDGAFLLRQVGEAVATLKGEFPTLQNKMRAVLRIEVEAVRFLKEEPHKLDSLLKRVRSMTDVLTMLRRHVTDGLLKGTDASQAAQYVAMEKATAAEVLKHQEETAHAPGQPLHCSTGSPGDVKSEVVPLSTMTVHHVQSSPVVMQPSQHSSALMNPAQNLPGGTRPHTASPPAITQEVTSAQSAPGPQSPQTPVNGSSMQSLFIEEIHSVSAKNRAVSIEKAEKKWEEKRQNLEHYNGKEFEKLLEEAQANIMKSIPNLEMPPASSPVSKGDAAGDKLELSEDSPNSEQELDKIGGKSPPPPPPPPRRSYLPGSGLTTTRSGDVVYTGRSMSKVSSEDPGPTPQTRATKCPPEEPASAWAPSPPPVPAPSSKEEEEEEEEGDKIMAELQAFQKCSFMDVNPNSHAEQSRANSHLKDTRAGATAPPKEKKNLEFYHEDVRKSDVECENGPQVESQKVTAGALRPSGPPKWERVMVDSISDTSRTSECRADTFTEENATPNKSLFRDSRNYSQKNVPKVSFSSSGLNSLEGEINKGPNVSGLQCAIPDLENQKLNFGKTKEIGQQGQENADKSHIPLPTRSAEFSIHDVKTQDQDVPVTGYGQVVLRSKVGRHANMNMNEDGESTPSSPSEEHTATDNIAFMITKTAVQVLSSGEVHDIVSQKGQDVQTVNIDGRKETASQHEGTEGEEPVVCLDKKPVIIIFDEPMDIRSAYKRLSTIFEECDEELERMLTEEKIEEEEEDENEDSGVRTSSQMSCEQVDSRSDRMGQKAETQSQPHVLSAELLTPGVQGVRKAEQRKLSSADSPDSGNKCGMVDDQFESPKKKFKFKFPKKQLAALTQAIRTGTKTGKKTLQVVVYEEEEEDGTLKQHKEAKRFEITRSQPEDALKTMARRQEQLSPEGTLPASRTDEIRKSTYRTLDSLEQTIKQLENTISEMSPRALVDTSCSSNRDCGASLPHMAQEVSPRSLLVLDEVPPAPEPPTSISPASRKGSSTTPQTSRMPVPMTSKNRPGSLDKASKQSKLQDPRQYRQANGSAKKAGGDCKPTSPSLPASKIPALSPSSGKSSSLPSASGDSSNLPNAPATKPSIASTPLSPQAGRSAHSASLIPSVSNGSLKFQSPPHAGKGHHHLSFALQTQNGRAAPTTSSSSSPPSPASPTSLNQGARGIRTIHTPSLASYKAQNGSSSKATPSTAKETS", "length": 1629, "header": "sp|A2AQ25-2|SKT_MOUSE Isoform 2 of Sickle tail protein OS=Mus musculus OX=10090 GN=Skt PE=1 SV=1 CANONICAL=A2AQ25-1" }, "locus": { "chromosome": "2", "start_pos": 20814018, "end_pos": 20748270, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000114608.3", "url": "https://www.ensembl.org/id/ENSMUST00000114608.3" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000110255.2", "url": "https://www.ensembl.org/id/ENSMUSP00000110255.2" } ] } }, { "isoform_ac": "A2AQ25-3", "url": "https://www.uniprot.org/uniprotkb/A2AQ25/entry#A2AQ25-3", "sequence": { "sequence": "MEESEGQKCEPNLPPSGDSRQMPQQGRSNLHVTSQEDAACRRPRERLSNGNARAQVSKPARNIPRRHTLGGPRSSKEILGMQPSEMDRKREAFLEHLKQKYPHHATAIMGHQERLRDQTKSPKLSHSPQPPNLGDPVEHLSETSGDSLEAMSEGEVPSPFARGSRTRASLPVVRSANQTKERSLGVLYLQYGDETKQLRMPNEVTSTDTIRALFVSAFPQQLTMKMLESPSVAIYIKDDSRNVYYELNDVRNIQDRSLLKVYNKDPSHAFNHMTKAVNGDMRMQREIVYARGDGLVAPRPGSVAHPPHVIPNSPPSTPVPHSLPPSPSRIPYGGSRPMAIPGNATIPRDRLSSLPVSRSISPSPSAILERRDVKPDEDMSSKNLVMFRNEGFYADPYLYHEGRMSIASSHGGHPLDVPDHVIAYHRTAIRSASAYCSPSLQAEMHMEQSLYRQKSRKYPDSHLPTLGSKTPPASPHRVGDLRMIDLHPHLNTHGPPHTLQPDRASPSRQSFKKEPGTLVYIEKPRNTSGLSSLVDLGPPLVEKQGFAYSTTTIPKDRETSEKMVKATANRNQADGAGTAHVSAGKVLGSVEFSLPPSQPLPAGTSPIHTSLLDMRRNVAELRLQLQQMRQLQLQNQEILRAMMKKAELEISNKVKETMKRLEDPVQRQRTLVEQERQKYLHEEERIVKKLCELEDFVEDLKKDSSSTGRVVTLKDVEDGAFLLRQVGEAVATLKGEFPTLQNKMRAVLRIEVEAVRFLKEEPHKLDSLLKRVRSMTDVLTMLRRHVTDGLLKGTDASQAAQYVAMEKATAAEVLKHQEETAHAPGQPLHCSTGSPGDVKSEVVPLSTMTVHHVQSSPVVMQPSQHSSALMNPAQNLPGGTRPHTASPPAITQEVTSAQSAPGPQSPQTPVNGSSMQSLFIEEIHSVSAKNRAVSIEKAEKKWEEKRQNLEHYNGKEFEKLLEEAQANIMKSIPNLEMPPASSPVSKGDAAGDKLELSEDSPNSEQELDKIGGKSPPPPPPPPRRSYLPGSGLTTTRSGDVVYTGRSMSKVSSEDPGPTPQTRATKCPPEEPASAWAPSPPPVPAPSSKEEEEEEEEGDKIMAELQAFQKCSFMDVNPNSHAEQSRANSHLKDTRAGATAPPKEKKGSSTTPQTSRMPVPMTSKNRPGSLDKASKQSKLQDPRQYRQANGSAKKAGGDCKPTSPSLPASKIPALSPSSGKSSSLPSASGDSSNLPNAPATKPSIASTPLSPQAGRSAHSASLIPSVSNGSLKFQSPPHAGKGHHHLSFALQTQNGRAAPTTSSSSSPPSPASPTSLNQGARGIRTIHTPSLASYKAQNGSSSKATPSTAKETS", "length": 1352, "header": "sp|A2AQ25-3|SKT_MOUSE Isoform 3 of Sickle tail protein OS=Mus musculus OX=10090 GN=Skt PE=1 SV=1 CANONICAL=A2AQ25-1" }, "locus": { "chromosome": "2", "start_pos": 20814018, "end_pos": 20524669, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000045555.11", "url": "https://www.ensembl.org/id/ENSMUST00000045555.11" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000041431.5", "url": "https://www.ensembl.org/id/ENSMUSP00000041431.5" } ] } }, { "isoform_ac": "A2AQ25-4", "url": "https://www.uniprot.org/uniprotkb/A2AQ25/entry#A2AQ25-4", "sequence": { "sequence": "MEESEGQKCEPNLPPSGDSRQMPQQGRSNLHVTSQEDAACRRPRERLSNGNARAQVSKPARNIPRRHTLGGPRSSKEILGMQPSEMDRKREAFLEHLKQKYPHHATAIMGHQERLRDQTKSPKLSHSPQPPNLGDPVEHLSETSGDSLEAMSEGEVPSPFARGSRTRASLPVVRSANQTKERSLGVLYLQYGDETKQLRMPNEVTSTDTIRALFVSAFPQQLTMKMLESPSVAIYIKDDSRNVYYELNDVRNIQDRSLLKVYNKDPSHAFNHMTKAVNGDMRMQREIVYARGDGLVAPRPGSVAHPPHVIPNSPPSTPVPHSLPPSPSRIPYGGSRPMAIPGNATIPRDRLSSLPVSRSISPSPSAILERRDVKPDEDMSSKNLVMFRNEGFYADPYLYHEGRMSIASSHGGHPLDVPDHVIAYHRTAIRSASAYCSPSLQAEMHMEQSLYRQKSRKYPDSHLPTLGSKTPPASPHRVGDLRMIDLHPHLNTHGPPHTLQPDRASPSRQSFKKEPGTLVYIEKPRNTSGLSSLVDLGPPLVEKQGFAYSTTTIPKDRETSEKMVKATANRNQADGAGTAHVSAGKVLGSVEFSLPPSQPLPAGTSPIHTSLLDMRRNVAELRLQLQQMRQLQLQNQEILRAMMKKAELEISNKVKETMKRLEDPVQRQRTLVEQERQKYLHEEERIVKKLCELEDFVEDLKKDSSSTGRVVTLKDVEDGAFLLRQVGEAVATLKGEFPTLQNKMRAVLRIEVEAVRFLKEEPHKLDSLLKRVRSMTDVLTMLRRHVTDGLLKGTDASQAAQYVAMEKATAAEVLKHQEETAHAPGQPLHCSTGSPGDVKSEVVPLSTMTVHHVQSSPVVMQPSQHSSALMNPAQNLPGGTRPHTASPPAITQEVTSAQSAPGPQSPQTPVNGSSMQSLFIEEIHSKAEKKWEEKRQNLEHYNGKEFEKLLEEAQANIMKSIPNLEMPPASSPVSKGDAAGDKLELSEDSPNSEQELDKIGGKSPPPPPPPPRRSYLPGSGLTTTRSGDVVYTGRSMSKVSSEDPGPTPQTRATKCPPEEPASAWAPSPPPVPAPSSKEEEEEEEEGDKIMAELQAFQKCSFMDVNPNSHAEQSRANSHLKDTRAGATAPPKEKKGSSTTPQTSRMPVPMTSKNRPGSLDKASKQSKLQDPRQYRQANGSAKKAGGDCKPTSPSLPASKIPALSPSSGKSSSLPSASGDSSNLPNAPATKPSIASTPLSPQAGRSAHSASLIPSVSNGSLKFQSPPHAGKGHHHLSFALQTQNGRAAPTTSSSSSPPSPASPTSLNQGARGIRTIHTPSLASYKAQNGSSSKATPSTAKETS", "length": 1341, "header": "sp|A2AQ25-4|SKT_MOUSE Isoform 4 of Sickle tail protein OS=Mus musculus OX=10090 GN=Skt PE=1 SV=1 CANONICAL=A2AQ25-1" }, "locus": { "chromosome": "2", "start_pos": 20814018, "end_pos": 20524669, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000114614.8", "url": "https://www.ensembl.org/id/ENSMUST00000114614.8" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000110261.2", "url": "https://www.ensembl.org/id/ENSMUSP00000110261.2" } ] } }, { "isoform_ac": "A2AQ25-5", "url": "https://www.uniprot.org/uniprotkb/A2AQ25/entry#A2AQ25-5", "sequence": { "sequence": "MQREIVYARGDGLVAPRPGSVAHPPHVIPNSPPSTPVPHSLPPSPSRIPYGGSRPMAIPGNATIPRDRLSSLPVSRSISPSPSAILERRDVKPDEDMSSKNLVMFRNEGFYADPYLYHEGRMSIASSHGGHPLDVPDHVIAYHRTAIRSASAYCSPSLQAEMHMEQSLYRQKSRKYPDSHLPTLGSKTPPASPHRVGDLRMIDLHPHLNTHGPPHTLQPDRASPSRQSFKKEPGTLVYIEKPRNTSGLSSLVDLGPPLVEKQGFAYSTTTIPKDRETSEKMVKATANRNQADGAGTAHVSAGKVLGSVEFSLPPSQPLPAGTSPIHTSLLDMRRNVAELRLQLQQMRQLQLQNQEILRAMMKKAELEISNKVKETMKRLEDPVQRQRTLVEQERQKYLHEEERIVKKLCELEDFVEDLKKDSSSTGRVVTLKDVEDGAFLLRQVGEAVATLKGEFPTLQNKMRAVLRIEVEAVRFLKEEPHKLDSLLKRVRSMTDVLTMLRRHVTDGLLKGTDASQAAQYVAMEKATAAEVLKHQEETAHAPGQPLHCSTGSPGDVKSEVVPLSTMTVHHVQSSPVVMQPSQHSSALMNPAQNLPGGTRPHTASPPAITQEVTSAQSAPGPQSPQTPVNGSSMQSLFIEEIHSVSAKNRAVSIEKAEKKWEEKRQNLEHYNGKEFEKLLEEAQANIMKSIPNLEMPPASSPVSKGDAAGDKLELSEDSPNSEQELDKIGGKSPPPPPPPPRRSYLPGSGLTTTRSGDVVYTGRSMSKVSSEDPGPTPQTRATKCPPEEPASAWAPSPPPVPAPSSKEEEEEEEEGDKIMAELQAFQKCSFMDVNPNSHAEQSRANSHLKDTRAGATAPPKEKKNLEFYHEDVRKSDVECENGPQVESQKGSSTTPQTSRMPVPMTSKNRPGSLDKASKQSKLQDPRQYRQVVLP", "length": 934, "header": "sp|A2AQ25-5|SKT_MOUSE Isoform 5 of Sickle tail protein OS=Mus musculus OX=10090 GN=Skt PE=1 SV=1 CANONICAL=A2AQ25-1" }, "locus": { "chromosome": "2", "start_pos": 20812847, "end_pos": 20748270, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000114607.8", "url": "https://www.ensembl.org/id/ENSMUST00000114607.8" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000110254.2", "url": "https://www.ensembl.org/id/ENSMUSP00000110254.2" } ] } }, { "isoform_ac": "A2AQ25-6", "url": "https://www.uniprot.org/uniprotkb/A2AQ25/entry#A2AQ25-6", "sequence": { "sequence": "MQREIVYARGDGLVAPRPGSVAHPPHVIPNSPPSTPVPHSLPPSPSRIPYGGSRPMAIPGNATIPRDRLSSLPVSRSISPSPSAILERRDVKPDEDMSSKNLVMFRNEGFYADPYLYHEGRMSIASSHGGHPLDVPDHVIAYHRTAIRSASAYCSPSLQAEMHMEQSLYRQKSRKYPDSHLPTLGSKTPPASPHRVGDLRMIDLHPHLNTHGPPHTLQPDRASPSRQSFKKEPGTLVYIEKPRNTSGLSSLVDLGPPLVEKQGFAYSTTTIPKDRETSEKMVKATANRNQADGAGTAHVSAGKVLGSVEFSLPPSQPLPAGTSPIHTSLLDMRRNVAELRLQLQQMRQLQLQNQEILRAMMKKAELEISNKVKETMKRLEDPVQRQRTLVEQERQKYLHEEERIVKKLCELEDFVEDLKKDSSSTGRVVTLKDVEDGAFLLRQVGEAVATLKGEFPTLQNKMRAVLRIEVEAVRFLKEEPHKLDSLLKRVRSMTDVLTMLRRHVTDGLLKGTDASQAAQYVAMEKATAAEVLKHQEETAHAPGQPLHCSTGSPGDVKSEVVPLSTMTVHHVQSSPVVMQPSQHSSALMNPAQNLPGGTRPHTASPPAITQEVTSAQSAPGPQSPQTPVNGSSMQSLFIEEIHSVSAKNRAVSIEKAEKKWEEKRQNLEHYNGKEFEKLLEEAQANIMKSIPNLEMPPASSPVSKGDAAGDKLELSEDSPNSEQELDKIGGKSPPPPPPPPRRSYLPGSGLTTTRSGDVVYTGRSMSKVSSEDPGPTPQTRATKCPPEEPASAWAPSPPPVPAPSSKEEEEEEEEGDKIMAELQAFQKCSFMDVNPNSHAEQSRANSHLKDTRAGATAPPKEKKGSSTTPQTSRMPVPMTSKNRPGSLDKASKQSKLQDPRQYRQVVLP", "length": 908, "header": "sp|A2AQ25-6|SKT_MOUSE Isoform 6 of Sickle tail protein OS=Mus musculus OX=10090 GN=Skt PE=1 SV=1 CANONICAL=A2AQ25-1" }, "locus": { "chromosome": "2", "start_pos": 20812847, "end_pos": 20748270, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000114606.8", "url": "https://www.ensembl.org/id/ENSMUST00000114606.8" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000110253.2", "url": "https://www.ensembl.org/id/ENSMUSP00000110253.2" } ] } }, { "isoform_ac": "A2AQ25-7", "url": "https://www.uniprot.org/uniprotkb/A2AQ25/entry#A2AQ25-7", "sequence": { "sequence": "MEESEGQKCEPNLPPSGDSRQMPQQGRSNLHVTSQEDAACRRPRERLSNGNARAQVSKPARNIPRRHTLGGPRSSKEILGMQPSEMDRKREAFLEHLKQKYPHHATAIMGHQERLRDQTKSPKLSHSPQPPNLGDPVEHLSETSGDSLEAMSEGEVPSPFARGSRTRASLPVVRSANQTKERSLGVLYLQYGDETKQLRMPNEVTSTDTIRALFVSAFPQQLTMKMLESPSVAIYIKDDSRNVYYELNDVR", "length": 251, "header": "sp|A2AQ25-7|SKT_MOUSE Isoform 7 of Sickle tail protein OS=Mus musculus OX=10090 GN=Skt PE=1 SV=1 CANONICAL=A2AQ25-1" }, "locus": {} }, { "isoform_ac": "A2AQ25-8", "url": "https://www.uniprot.org/uniprotkb/A2AQ25/entry#A2AQ25-8", "sequence": { "sequence": "MEESEGQKCEPNLPPSGDSRQMPQQGRSNLHVTSQEDAACRRPRERLSNGNARAQVSKPARNIPRRHTLGGPRSSKEILGMQPSEMDRKREAFLEHLKQKYPHHATAIMGHQERLRDQTKSPKLSHSPQPPNLGDPVEHLSETSGDSLEAMSEGEVPSPFARGSRTRASLPVVRSANQTKERSLGVLYLQYGDETKQLRMPNEVTSTDTIRALFVSAFPQQLTMKMLESPSVAIYIKDDSRNVYYELNDVRNIQDRSLLKVYNKDPSHAFNHMTKAVNGDMRMQREIVYARGDGLVAPRPGSVAHPPHVIPNSPPSTPVPHSLPPSPSRIPYGGSRPMAIPGNATIPRDRLSSLPVSRSISPSPSAILERRDVKPDEDMSSKNLVMFRNEGFYADPYLYHEGRMSIASSHGGHPLDVPDHVIAYHRTAIRSASAYCSPSLQAEMHMEQSLYRQKSRKYPDSHLPTLGSKTPPASPHRVGDLRMIDLHPHLNTHGPPHTLQPDRASPSRQSFKKEPGTLVYIEKPRNTSGLSSLVDLGPPLVEKQGFAYSTTTIPKDRETSEKMVKATANRNQADGAGTAHVSAGKVLGSVEFSLPPSQPLPAGTSPIHTSLLDMRRNVAELRLQLQQMRQLQLQNQEILRAMMKKAELEISNKVKETMKRLEDPVQRQRTLVEQERQKYLHEEERIVKKLCELEDFVEDLKKDSSSTGRVVTLKDVEDGAFLLRQVGEAVATLKGEFPTLQNKMRAVLRIEVEAVRFLKEEPHKLDSLLKRVRSMTDVLTMLRRHVTDGLLKGTDASQAAQYVAMEKATAAEVLKHQEETAHAPGQPLHCSTGSPGDVKSEVVPLSTMTSKNRPGSLDKASKQSKLQDPRQYRQANGSAKKAGGDCKPTSPSLPASKIPALSPSSGKSSSLPSASGDSSNLPNAPATKPSIASTPLSPQAGRSAHSASLIPSVSNGSLKFQSPPHAGKGHHHLSFALQTQNGRAAPTTSSSSSPPSPASPTSLNQGARGIRTIHTPSLASYKAQNGSSSKATPSTAKETS", "length": 1040, "header": "sp|A2AQ25-8|SKT_MOUSE Isoform 8 of Sickle tail protein OS=Mus musculus OX=10090 GN=Skt PE=1 SV=1 CANONICAL=A2AQ25-1" }, "locus": {} }, { "isoform_ac": "A2AQ25-9", "url": "https://www.uniprot.org/uniprotkb/A2AQ25/entry#A2AQ25-9", "sequence": { "sequence": "MQREIVYARGDGLVAPRPGSVAHPPHVIPNSPPSTPVPHSLPPSPSRIPYGGSRPMAIPGNATIPRDRLSSLPVSRSISPSPSAILERRDVKPDEDMSSKNLVMFRNEGFYADPYLYHEGRMSIASSHGGHPLDVPDHVIAYHRTAIRSASAYCSPSLQAEMHMEQSLYRQKSRKYPDSHLPTLGSKTPPASPHRVGDLRMIDLHPHLNTHGPPHTLQPDRASPSRQSFKKEPGTLVYIEKPRNTSGLSSLVDLGPPLVEKQGFAYSTTTIPKDRETSEKMVKATANRNQADGAGTAHVSAGKVLGSVEFSLPPSQPLPAGTSPIHTSLLDMRRNVAELRLQLQQMRQLQLQNQEILRAMMKKAELEISNKVKETMKRLEDPVQRQRTLVEQERQKYLHEEERIVKKLCELEDFVEDLKKDSSSTGRVVTLKDVEDGAFLLRQVGEAVATLKGEFPTLQNKMRAVLRIEVEAVRFLKEEPHKLDSLLKRVRSMTDVLTMLRRHVTDGLLKGTDASQAAQYVAMEKATAAEVLKHQEETAHAPGQPLHCSTGSPGDVKSEVVPLSTMTVHHVQSSPVVMQPSQHSSALMNPAQNLPGGTRPHTASPPAITQEVTSAQSAPGPQSPQTPVNGSSMQSLFIEEIHSKAEKKWEEKRQNLEHYNGKEFEKLLEEAQANIMKSIPNLEMPPASSPVSKGDAAGDKLELSEDSPNSEQELDKIGGKSPPPPPPPPRRSYLPGSGLTTTRSGDVVYTGRSMSKVSSEDPGPTPQTRATKCPPEEPASAWAPSPPPVPAPSSKEEEEEEEEGDKIMAELQAFQKCSFMDVNPNSHAEQSRANSHLKDTRAGATAPPKEKKVTCGSYTFTIQ", "length": 863, "header": "sp|A2AQ25-9|SKT_MOUSE Isoform 9 of Sickle tail protein OS=Mus musculus OX=10090 GN=Skt PE=1 SV=1 CANONICAL=A2AQ25-1" }, "locus": {} }, { "isoform_ac": "B1AY49-1", "url": "https://www.uniprot.org/uniprotkb/A2AQ25/entry#B1AY49-1", "sequence": { "sequence": "MSLCPPPCCLLRSFFTNAAAKLPSSKKDDLSSKQKKTSRGDKTERIGSEGNLTEYQQVQAAATSAQRKAAAAHKEQGRSNLHVTSQEDAACRRPRERLSNGNARAQVSKPARNIPRRHTLGGPRSSKEILGMQPSEMDRKREAFLEHLKQKYPHHATAIMGHQERLRDQTKSPKLSHSPQPPNLGDPVEHLSETSGDSLEAMSEGEVPSPFARGSRTRAS", "length": 220, "header": "tr|B1AY49-1|SKT_MOUSE Computationally mapped isoform of Sickle tail protein OS=Mus musculus OX=10090 GN=Skt PE=1 SV=8 CANONICAL=A2AQ25-1" }, "locus": { "chromosome": "2", "start_pos": 20666861, "end_pos": 20294818, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000146881.8", "url": "https://www.ensembl.org/id/ENSMUST00000146881.8" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000119778.2", "url": "https://www.ensembl.org/id/ENSMUSP00000119778.2" } ] } }, { "isoform_ac": "B1AY50-1", "url": "https://www.uniprot.org/uniprotkb/A2AQ25/entry#B1AY50-1", "sequence": { "sequence": "MSKSSRSARSFFTNAAAKLPSSKKDDLSSKQKKTSRGDKTERIGSEGNLTEYQQVQAAATSAQRKAAAAHKEQGRSNLHVTSQEDAACRRPRERLSNGNARAQVSKPARNIPRRHTLGGPRSSKEILGMQPSEMDRKREAFLEHLKQKYPHHATAIMGHQERLRDQTKSPKLS", "length": 173, "header": "tr|B1AY50-1|SKT_MOUSE Computationally mapped isoform of Sickle tail protein OS=Mus musculus OX=10090 GN=Skt PE=1 SV=1 CANONICAL=A2AQ25-1" }, "locus": { "chromosome": "2", "start_pos": 20666729, "end_pos": 20344707, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000131714.8", "url": "https://www.ensembl.org/id/ENSMUST00000131714.8" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000116637.2", "url": "https://www.ensembl.org/id/ENSMUSP00000116637.2" } ] } }, { "isoform_ac": "D3Z781-1", "url": "https://www.uniprot.org/uniprotkb/A2AQ25/entry#D3Z781-1", "sequence": { "sequence": "MEESEGQKCEPNLPPSGDSRQMPQQGRSNLHVTSQEDAACRRPRERLSNGNARAQVSKPARNIPRRHTLGGPRSSKEILGMQPSEMDRKREAFLEHLKQKYPHHATAIMGHQERLRDQTKSPKLSHSPQPPNLGDPVEHLSETSGDSLEAMSEGEVPSPFARGSRTRASLPVVRSANQTKERSLGVLYLQYGDETKQLRMPNEVTSTDTIRALFVSAFPQQLTMKMLESPSVAIYIKDDSRNVYYELNDVRNIQDRSLLKVYNKDPSHAFNHMTKAVNGDMRMQREIVYARGDGLVAPRPGSVAHPPHVIPNSPPSTPVPHSLPPSPSRIPYGGSRPMAIPGNATIPRDRLSSLPVSRSISPSPSAILERRDVKPDEDMSSKNLVMFRNEGFYADPYLYHEGRMSIASSHGGHPLDVPDHVIAYHRTAIRSASAYCSPSLQAEMHMEQSLYRQKSRKYPDSHLPTLGSKTPPASPHRVGDLRMIDLHPHLNTHGPPHTLQPDRASPSRQSFKKEPGTLVYIEKPRNTSGLSSLVDLGPPLVEKQGFAYSTTTIPKDRETRERMQAMEKQIASLTGLVQSALFKGPITSSSKEASSEKMVKATANRNQADGAGTAHVSAGKVLGSVEFSLPPSQPLPAGTSPIHTSLLDMRRNVAELRLQLQQMRQLQLQNQEILRAMMKKAELEISNKVKETMKRLEDPVQRQRTLVEQERQKYLHEEERIVKKLCELEDFVEDLKKDSSSTGRVVTLKDVEDGAFLLRQVGEAVATLKGEFPTLQNKMRAVLRIEVEAVRFLKEEPHKLDSLLKRVRSMTDVLTMLRRHVTDGLLKGTDASQAAQYVAMEKATAAEVLKHQEETAHAPGQPLHCSTGSPGDVKSEVVPLSTMTVHHVQSSPVVMQPSQHSSALMNPAQNLPGGTRPHTASPPAITQEVTSAQSAPGPQSPQTPVNGSSMQSLFIEEIHSVSAKNRAVSIEKAEKKWEEKRQNLEHYNGKEFEKLLEEAQANIMKSIPNLEMPPASSPVSKGDAAGDKLELSEDSPNSEQELDKIGGKSPPPPPPPPRRSYLPGSGLTTTRSGDVVYTGRSMSKVSSEDPGPTPQTRATKCPPEEPASAWAPSPPPVPAPSSKEEEEEEEEGDKIMAELQGSSTTPQTSRMPVPMTSKNRPGSLDKASKQSKLQDPRQYRQANGSAKKAGGDCKPTSPSLPASKIPALSPSSGKSSSLPSASGDSSNLPNAPATKPSIASTPLSPQAGRSAHSASLIPSVSNGSLKFQSPPHAGKGHHHLSFALQTQNGRAAPTTSSSSSPPSPASPTSLNQGARGIRTIHTPSLASYKAQNGSSSKATPSTAKETS", "length": 1347, "header": "tr|D3Z781-1|SKT_MOUSE Computationally mapped isoform of Sickle tail protein OS=Mus musculus OX=10090 GN=Skt PE=1 SV=2 CANONICAL=A2AQ25-1" }, "locus": { "chromosome": "2", "start_pos": 20814018, "end_pos": 20524669, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000114604.9", "url": "https://www.ensembl.org/id/ENSMUST00000114604.9" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000110251.3", "url": "https://www.ensembl.org/id/ENSMUSP00000110251.3" } ] } }, { "isoform_ac": "E9QAU4-1", "url": "https://www.uniprot.org/uniprotkb/A2AQ25/entry#E9QAU4-1", "sequence": { "sequence": "MSLCPPPCCLLRSFFTNAAAKLPSSKKDDLSSKQKKTSRGDKTERIGSEGNLTEYQQVQAAATSAQRKAAAAHKEQGRSNLHVTSQEDAACRRPRERLSNGNARAQVSKPARNIPRRHTLGGPRSSKEILGMQPSEMDRKREAFLEHLKQKYPHHATAIMGHQERLRDQTKSPKLSHSPQPPNLGDPVEHLSETSGDSLEAMSEGEVPSPFARGSRTRASLPVVRSANQTKERSLGVLYLQYGDETKQLRMPNEVTSTDTIRALFVSAFPQQLTMKMLESPSVAIYIKDDSRNVYYELNDVRNIQDRSLLKVYNKDPSHAFNHMTKAVNGDMRMQREIVYARGDGLVAPRPGSVAHPPHVIPNSPPSTPVPHSLPPSPSRIPYGGSRPMAIPGNATIPRDRLSSLPVSRSISPSPSAILERRDVKPDEDMSSKNLVMFRNEGFYADPYLYHEGRMSIASSHGGHPLDVPDHVIAYHRTAIRSASAYCSPSLQAEMHMEQSLYRQKSRKYPDSHLPTLGSKTPPASPHRVGDLRMIDLHPHLNTHGPPHTLQPDRASPSRQSFKKEPGTLVYIEKPRNTSGLSSLVDLGPPLVEKQGFAYSTTTIPKDRETRERMQAMEKQIASLTGLVQSALFKGPITSSSKEASSEKMVKATANRNQADGAGTAHVSAGKVLGSVEFSLPPSQPLPAGTSPIHTSLLDMRRNVAELRLQLQQMRQLQLQNQEILRAMMKKAELEISNKVKETMKRLEDPVQRQRTLVEQERQKYLHEEERIVKKLCELEDFVEDLKKDSSSTGRVVTLKDVEDGAFLLRQVGEAVATLKGEFPTLQNKMRAVLRIEVEAVRFLKEEPHKLDSLLKRVRSMTDVLTMLRRHVTDGLLKGTDASQAAQYVAMEKATAAEVLKHQEETAHAPGQPLHCSTGSPGDVKSEVVPLSTMTVHHVQSSPVVMQPSQHSSALMNPAQNLPGGTRPHTASPPAITQEVTSAQSAPGPQSPQTPVNGSSMQSLFIEEIHSVSAKNRAVSIEKAEKKWEEKRQNLEHYNGKEFEKLLEEAQANIMKSIPNLEMPPASSPVSKGDAAGDKLELSEDSPNSEQELDKIGGKSPPPPPPPPRRSYLPGSGLTTTRSGDVVYTGRSMSKVSSEDPGPTPQTRATKCPPEEPASAWAPSPPPVPAPSSKEEEEEEEEGDKIMAELQAFQKCSFMDVNPNSHAEQSRANSHLKDTRAGATAPPKEKKNLEFYHEDVRKSDVECENGPQVESQKVTAGALRPSGPPKWERVMVDSISDTSRTSECRADTFTEENATPNKSLFRDSRNYSQKNVPKVSFSSSGLNSLEGEINKGPNVSGLQCAIPDLENQKLNFGKTKEIGQQGQENADKSHIPLPTRSAEFSIHDVKTQDQDVPVTGYGQVVLRSKVGRHANMNMNEDGESTPSSPSEEHTATDNIAFMITKTAVQVLSSGEVHDIVSQKGQDVQTVNIDGRKETASQHEGTEGEEPVVCLDKKPVIIIFDEPMDIRSAYKRLSTIFEECDEELERMLTEEKIEEEEEDENEDSGVRTSSQMSCEQVDSRSDRMGQKAETQSQPHVLSAELLTPGVQGVRKAEQRKLSSADSPDSGNKCGMVDDQFESPKKKFKFKFPKKQLAALTQAIRTGTKTGKKTLQVVVYEEEEEDGTLKQHKEAKRFEITRSQPEDALKTMARRQEQLSPEGTLPASRTDEIRKSTYRTLDSLEQTIKQLENTISEMSPRALVDTSCSSNRDCGASLPHMAQEVSPRSLLVLDEVPPAPEPPTSISPASRKGSSTTPQTSRMPVPMTSKNRPGSLDKASKQSKLQDPRQYRQANGSAKKAGGDCKPTSPSLPASKIPALSPSSGKSSSLPSASGDSSNLPNAPATKPSIASTPLSPQAGRSAHSASLIPSVSNGSLKFQSPPHAGKGHHHLSFALQTQNGRAAPTTSSSSSPPSPASPTSLNQGARGIRTIHTPSLASYKAQNGSSSKATPSTAKETS", "length": 1997, "header": "tr|E9QAU4-1|SKT_MOUSE Computationally mapped isoform of Sickle tail protein OS=Mus musculus OX=10090 GN=Skt PE=1 SV=1 CANONICAL=A2AQ25-1" }, "locus": { "chromosome": "2", "start_pos": 20814018, "end_pos": 20294818, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000114627.8", "url": "https://www.ensembl.org/id/ENSMUST00000114627.8" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000110274.2", "url": "https://www.ensembl.org/id/ENSMUSP00000110274.2" } ] } }, { "isoform_ac": "Q8BHR1-1", "url": "https://www.uniprot.org/uniprotkb/A2AQ25/entry#Q8BHR1-1", "sequence": { "sequence": "MQPSEMDRKREAFLEHLKQKYPHHATAIMGHQERLRDQTKSPKLSHSPQPPNLGDPVEHLSETSGDSLEAMSEGEVPSPFARGSRTRASLPVVRSANQTKERSLGVLYLQYGDETKQLRMPNEVTSTDTIRALFVSAFPQQLTMKMLESPSVAIYIKDDSRNVYYELNDVRNIQDRSLLKVYNKDPSHAFNHMTKAVNGDMRMQREIVYARGDGLVAPRPGSVAHPPHVIPNSPPSTPVPHSLPPSPSRIPYGGSRPMAIPGNATIPRDRLSSLPVSRSISPSPSAILERRDVKPDEDMSSKNLVMFRNEGFYADPYLYHEGRMSIASSHGGHPLDVPDHVIAYHRTAIRSASAYCSPSLQAEMHMEQSLYRQKSRKYPDSHLPTLGSKTPPASPHRVGDLRMIDLHPHLNTHGPPHTLQPDRASPSRQSFKKEPGTLVYIEKPRNTSGLSSLVDLGPPLVEKQGFAYSTTTIPKDRETR", "length": 480, "header": "tr|Q8BHR1-1|SKT_MOUSE Computationally mapped isoform of Sickle tail protein OS=Mus musculus OX=10090 GN=Skt PE=1 SV=1 CANONICAL=A2AQ25-1" }, "locus": { "chromosome": "2", "start_pos": 20749103, "end_pos": 20534940, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000114610.8", "url": "https://www.ensembl.org/id/ENSMUST00000114610.8" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000110257.2", "url": "https://www.ensembl.org/id/ENSMUSP00000110257.2" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 1069, "start_aa": "Thr", "end_pos": 1069, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1069", "evidence": [ { "id": "32848054", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32848054" }, { "id": "A2AQ25", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/A2AQ25" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 1070, "start_aa": "Thr", "end_pos": 1070, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1070", "evidence": [ { "id": "22645316", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/22645316" }, { "id": "A2AQ25", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/A2AQ25" }, { "id": "32848054", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32848054" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 1096, "start_aa": "Thr", "end_pos": 1096, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1096", "evidence": [ { "id": "32848054", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32848054" }, { "id": "A2AQ25", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/A2AQ25" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 1340, "start_aa": "Thr", "end_pos": 1340, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1340", "evidence": [ { "id": "22517741", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/22517741" }, { "id": "A2AQ25", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=A2AQ25" }, { "id": "16452088", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/16452088" }, { "id": "22645316", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/22645316" }, { "id": "36852467", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/36852467" }, { "id": "35822049", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35822049" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 1348, "start_aa": "Thr", "end_pos": 1348, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1348", "evidence": [ { "id": "22517741", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/22517741" }, { "id": "A2AQ25", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=A2AQ25" }, { "id": "16452088", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/16452088" }, { "id": "22645316", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/22645316" }, { "id": "36852467", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/36852467" }, { "id": "35822049", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35822049" }, { "id": "A2AQ25", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/A2AQ25" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 1894, "start_aa": "Thr", "end_pos": 1894, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1894", "evidence": [ { "id": "22645316", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/22645316" }, { "id": "A2AQ25", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/A2AQ25" }, { "id": "32848054", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32848054" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 1895, "start_aa": "Ser", "end_pos": 1895, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser1895", "evidence": [ { "id": "22517741", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/22517741" }, { "id": "A2AQ25", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=A2AQ25" }, { "id": "16452088", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/16452088" }, { "id": "22645316", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/22645316" }, { "id": "36852467", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/36852467" }, { "id": "35822049", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35822049" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 1896, "start_aa": "Ser", "end_pos": 1896, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser1896", "evidence": [ { "id": "22645316", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/22645316" }, { "id": "A2AQ25", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/A2AQ25" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 1897, "start_aa": "Ser", "end_pos": 1897, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser1897", "evidence": [ { "id": "22645316", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/22645316" }, { "id": "A2AQ25", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/A2AQ25" } ] }, { "glytoucan_ac": "G46910OC", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "PMAIPGNATIPR", "relation": "attached", "comment": "", "start_pos": 343, "start_aa": "N", "end_pos": 343, "end_aa": "N", "residue": "Asn", "site_lbl": "Asn343", "evidence": [ { "id": "10.1101/2023.09.13.557529v1", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1101/2023.09.13.557529v1" }, { "id": "GLY_000889", "database": "GlyGen", "url": "https://data.glygen.org/GLY_000889" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 357, "start_aa": "Ser", "end_pos": 357, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser357", "evidence": [ { "id": "22517741", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/22517741" }, { "id": "A2AQ25", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=A2AQ25" }, { "id": "16452088", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/16452088" }, { "id": "22645316", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/22645316" }, { "id": "36852467", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/36852467" }, { "id": "35822049", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35822049" }, { "id": "A2AQ25", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/A2AQ25" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported", "site_seq": "S", "relation": "attached", "comment": "O-linked (GlcNAc) serine O-GlcNAcylation", "start_pos": 357, "start_aa": "Ser", "end_pos": 357, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser357", "evidence": [ { "id": "A2AQ25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2AQ25#ptm_processing" }, { "id": "16452088", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/16452088" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 588, "start_aa": "Ser", "end_pos": 588, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser588", "evidence": [ { "id": "32848054", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32848054" }, { "id": "A2AQ25", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/A2AQ25" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 617, "start_aa": "Ser", "end_pos": 617, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser617", "evidence": [ { "id": "32848054", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32848054" }, { "id": "A2AQ25", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/A2AQ25" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "", "relation": "attached", "comment": "O-GlcNAcylation", "evidence": [ { "id": "34678516", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34678516" }, { "id": "A2AQ25", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=A2AQ25" } ] } ], "phosphorylation": [ { "start_pos": 1032, 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"http://research.bioinformatics.udel.edu/iptmnet/entry/A2AQ25" } ], "site_lbl": "Tyr548" }, { "start_pos": 68, "end_pos": 68, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "A2AQ25", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2AQ25" } ], "site_lbl": "Thr68" }, { "start_pos": 809, "end_pos": 809, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A2AQ25", "url": "https://www.uniprot.org/uniprot/A2AQ25" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" }, { "database": "iPTMnet", "id": "A2AQ25", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2AQ25" } ], "site_lbl": "Ser809" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_reported", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "Deep quantitative glycoproteomics reveals gut microbiome induced remodeling of the brain glycoproteome", "journal": "bioRxiv", "date": "2023", "authors": "Potel C.M., Burtscher M.L., Garrido-Rodriguez M., Brauer-Nikonow A., Becher I., Typas A., Zimmermann M., Savitski M.", "evidence": [ { "database": "DOI", "id": "10.1101/2023.09.13.557529v1", "url": "https://glygen.org/publication/DOI/10.1101/2023.09.13.557529v1" } ], "reference": [ { "type": "DOI", "id": "10.1101/2023.09.13.557529v1", "url": "https://glygen.org/publication/DOI/10.1101/2023.09.13.557529v1" } ] }, { "title": "Identification of targets for calcium signaling through the copine family of proteins. Characterization of a coiled-coil copine-binding motif.", "journal": "J. Biol. Chem.", "date": "2003", "authors": "Tomsig JL, Snyder SL, Creutz CE", "evidence": [ { "database": "UniProtKB", "id": "A2AQ25", "url": "https://www.uniprot.org/uniprot/A2AQ25" } ], "reference": [ { "type": "PubMed", "id": "12522145", "url": "https://glygen.org/publication/PubMed/12522145" } ] }, { "title": "A novel murine gene, Sickle tail, linked to the Danforth's short tail locus, is required for normal development of the intervertebral disc.", "journal": "Genetics", "date": "2006-01", "authors": "Semba Kei, Araki Kimi, Li Zhengzhe, Matsumoto Ken-ichirou, Suzuki Misao, Nakagata Naoki, Takagi Katsumasa, Takeya Motohiro, Yoshinobu Kumiko, Araki Masatake, Imai Kenji, Abe Kuniya, Yamamura Ken-ichi", "evidence": [ { "database": "UniProtKB", "id": "A2AQ25", "url": "https://www.uniprot.org/uniprot/A2AQ25" } ], "reference": [ { "type": "PubMed", "id": "16204209", "url": "https://glygen.org/publication/PubMed/16204209" } ] }, { "title": "O-linked N-acetylglucosamine proteomics of postsynaptic density preparations using lectin weak affinity chromatography and mass spectrometry.", "journal": "Molecular & cellular proteomics : MCP", "date": "2006", "authors": "Vosseller K, Trinidad JC, Chalkley RJ, Specht CG, Thalhammer A, Lynn AJ, Snedecor JO, Guan S, Medzihradszky KF, Maltby DA, Schoepfer R, Burlingame AL", "evidence": [ { "database": "UniProtKB", "id": "A2AQ25", "url": "https://www.uniprot.org/uniprot/A2AQ25#ptm_processing" }, { "database": "UniProtKB", "id": "A2AQ25", "url": "https://www.uniprot.org/uniprot/A2AQ25" }, { "database": "O-GlcNAc Database", "id": "A2AQ25", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=A2AQ25" }, { "database": "O-GlcNAc Atlas", "id": "A2AQ25", "url": "https://oglcnac.org/atlas/detail/A2AQ25" } ], "reference": [ { "type": "PubMed", "id": "16452088", "url": "https://glygen.org/publication/PubMed/16452088" } ] }, { "title": "Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.", "journal": "Mol. Cell. Proteomics", "date": "2007", "authors": "Munton RP, Tweedie-Cullen R, Livingstone-Zatchej M, Weinandy F, Waidelich M, Longo D, Gehrig P, Potthast F, Rutishauser D, Gerrits B, Panse C, Schlapbach R, Mansuy IM", "evidence": [ { "database": "UniProtKB", "id": "E9QAU4", "url": "https://www.uniprot.org/uniprot/E9QAU4" }, { "database": "iPTMnet", "id": "A2AQ25", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2AQ25" } ], "reference": [ { "type": "PubMed", "id": "17114649", "url": "https://glygen.org/publication/PubMed/17114649" } ] }, { "title": "Large-scale phosphorylation analysis of mouse liver.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2007", "authors": "Villen J, Beausoleil SA, Gerber SA, Gygi SP", "evidence": [ { "database": "UniProtKB", "id": "A2AQ25", "url": "https://www.uniprot.org/uniprot/A2AQ25" }, { "database": "iPTMnet", "id": "A2AQ25", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2AQ25" } ], "reference": [ { "type": "PubMed", "id": "17242355", "url": "https://glygen.org/publication/PubMed/17242355" } ] }, { "title": "A tissue-specific atlas of mouse protein phosphorylation and expression.", "journal": "Cell", "date": "2010", "authors": "Huttlin EL, Jedrychowski MP, Elias JE, Goswami T, Rad R, Beausoleil SA, Villen J, Haas W, Sowa ME, Gygi SP", "evidence": [ { "database": "UniProtKB", "id": "A2AQ25", "url": "https://www.uniprot.org/uniprot/A2AQ25" }, { "database": "iPTMnet", "id": "A2AQ25", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2AQ25" } ], "reference": [ { "type": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" } ] }, { "title": "Tandem mass spectrometry identifies many mouse brain O-GlcNAcylated proteins including EGF domain-specific O-GlcNAc transferase targets.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2012", "authors": "Alfaro JF, Gong CX, Monroe ME, Aldrich JT, Clauss TR, Purvine SO, Wang Z, Camp DG 2nd, Shabanowitz J, Stanley P, Hart GW, Hunt DF, Yang F, Smith RD", "evidence": [ { "database": "O-GlcNAc Database", "id": "A2AQ25", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=A2AQ25" }, { "database": "O-GlcNAc Atlas", "id": "A2AQ25", "url": "https://oglcnac.org/atlas/detail/A2AQ25" } ], "reference": [ { "type": "PubMed", "id": "22517741", "url": "https://glygen.org/publication/PubMed/22517741" } ] }, { "title": "Global identification and characterization of both O-GlcNAcylation and phosphorylation at the murine synapse.", "journal": "Molecular & cellular proteomics : MCP", "date": "2012", "authors": "Trinidad JC, Barkan DT, Gulledge BF, Thalhammer A, Sali A, Schoepfer R, Burlingame AL", "evidence": [ { "database": "O-GlcNAc Database", "id": "A2AQ25", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=A2AQ25" }, { "database": "O-GlcNAc Atlas", "id": "A2AQ25", "url": "https://oglcnac.org/atlas/detail/A2AQ25" } ], "reference": [ { "type": "PubMed", "id": "22645316", "url": "https://glygen.org/publication/PubMed/22645316" } ] }, { "title": "Generation of an 870 kb deletion encompassing the Skt/Etl4 locus by combination of inter- and intra-chromosomal recombination.", "journal": "BMC genetics", "date": "2015", "authors": "Serth K, Beckers A, Schuster-Gossler K, Pavlova MN, Muller J, Paul MC, Reinhardt R, Gossler A", "evidence": [ { "database": "RefSeq", "id": "NP_001074475", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074475" } ], "reference": [ { "type": "PubMed", "id": "26678520", "url": "https://glygen.org/publication/PubMed/26678520" } ] }, { "title": "Age-related loss of neural stem cell O-GlcNAc promotes a glial fate switch through STAT3 activation.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2020", "authors": "White CW 3rd, Fan X, Maynard JC, Wheatley EG, Bieri G, Couthouis J, Burlingame AL, Villeda SA", "evidence": [ { "database": "O-GlcNAc Atlas", "id": "A2AQ25", "url": "https://oglcnac.org/atlas/detail/A2AQ25" } ], "reference": [ { "type": "PubMed", "id": "32848054", "url": "https://glygen.org/publication/PubMed/32848054" } ] }, { "title": "A Genetic Screen Identifies Etl4-Deficiency Capable of Stabilizing the Haploidy in Embryonic Stem Cells.", "journal": "Stem cell reports", "date": "2021", "authors": "Zhang G, Li X, Sun Y, Wang X, Liu G, Huang Y", "evidence": [ { "database": "RefSeq", "id": "NP_001074475", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074475" } ], "reference": [ { "type": "PubMed", "id": "33440180", "url": "https://glygen.org/publication/PubMed/33440180" } ] }, { "title": "Novel Antibodies for the Simple and Efficient Enrichment of Native O-GlcNAc Modified Peptides.", "journal": "Molecular & cellular proteomics : MCP", "date": "2021", "authors": "Burt RA, Dejanovic B, Peckham HJ, Lee KA, Li X, Ounadjela JR, Rao A, Malaker SA, Carr SA, Myers SA", "evidence": [ { "database": "O-GlcNAc Database", "id": "A2AQ25", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=A2AQ25" } ], "reference": [ { "type": "PubMed", "id": "34678516", "url": "https://glygen.org/publication/PubMed/34678516" } ] }, { "title": "Defining the Dynamic Regulation of O-GlcNAc Proteome in the Mouse Cortex---the O-GlcNAcylation of Synaptic and Trafficking Proteins Related to Neurodegenerative Diseases.", "journal": "Frontiers in aging", "date": "2021", "authors": "Huynh Van N, Wang Sheng, Ouyang Xiaosen, Wani Willayat Y, Johnson Michelle S, Chacko Balu K, Jegga Anil G, Qian Wei-Jun, Chatham John C, Darley-Usmar Victor M, Zhang Jianhua", "evidence": [ { "database": "O-GlcNAc Database", "id": "A2AQ25", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=A2AQ25" } ], "reference": [ { "type": "PubMed", "id": "35822049", "url": "https://glygen.org/publication/PubMed/35822049" } ] }, { "title": "Chemoproteomic and Transcriptomic Analysis Reveals that O-GlcNAc Regulates Mouse Embryonic Stem Cell Fate through the Pluripotency Network.", "journal": "Angewandte Chemie (International ed. in English)", "date": "2023-02-27", "authors": "Hao Yi, Li Xiang, Qin Ke, Shi Yujie, He Yanwen, Zhang Che, Cheng Bo, Zhang Xiwen, Hu Guangyu, Liang Shuyu, Tang Qi, Chen Xing", "evidence": [ { "database": "O-GlcNAc Database", "id": "A2AQ25", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=A2AQ25" } ], "reference": [ { "type": "PubMed", "id": "36852467", "url": "https://glygen.org/publication/PubMed/36852467" } ] } ], "pathway": [ { "id": "mmu:208618", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:208618", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8I5YBN1-1", "protein_name": "Enhancer trap locus 4", "gene_name": "Etl4", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": 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"length": 1940 }, "evidence": [ { "id": "A2AQ25", "url": "https://omabrowser.org/oma/group/A2AQ25/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q5T5P2-1", "protein_name": "Sickle tail protein homolog", "gene_name": "KIAA1217", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": 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"length": 1943 }, "evidence": [ { "id": "46368863", "url": "http://www.informatics.jax.org/homology/46368863", "database": "MGI" }, { "id": "A2AQ25", "url": "https://omabrowser.org/oma/group/A2AQ25/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "centrosome", "id": "GO:0005813", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813", "evidence": [ { "database": "UniProtKB", "id": "A2AQ25", "url": "https://www.uniprot.org/uniprot/A2AQ25" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A2AQ25", "url": "https://www.uniprot.org/uniprot/A2AQ25" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "embryonic skeletal system development", "id": "GO:0048706", "url": 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