{
    "uniprot_canonical_ac": "A2APF3-1",
    "uniprot_ac": "A2APF3",
    "uniprot_id": "CTCFL_MOUSE",
    "mass": {
        "chemical_mass": 73108.0,
        "monoisotopic_mass": 73108.0
    },
    "refseq": {
        "ac": "NP_001074856",
        "name": "transcriptional repressor CTCFL isoform 2",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074856"
    },
    "gene_names": [
        {
            "name": "Ctcfl",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/A2APF3",
            "id": "A2APF3"
        },
        {
            "name": "Boris",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074856",
            "id": "NP_001074856"
        },
        {
            "name": "Boris",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A2APF3",
            "id": "A2APF3"
        },
        {
            "name": "Ctcfl",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074856",
            "id": "NP_001074856"
        }
    ],
    "protein_names": [
        {
            "name": "Transcriptional repressor CTCFL",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprotkb/A2APF3/entry#names_and_taxonomy",
            "id": "A2APF3"
        },
        {
            "name": "Brother of the regulator of imprinted sites",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprotkb/A2APF3/entry#names_and_taxonomy",
            "id": "A2APF3"
        },
        {
            "name": "CCCTC-binding factor",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprotkb/A2APF3/entry#names_and_taxonomy",
            "id": "A2APF3"
        },
        {
            "name": "CTCF paralog; CTCF-like protein; Transcriptional repressor CTCFL; Brother of the regulator of imprinted sites; BORIS; likely orthologue of H. sapiens CCCTC-binding factor-like protein (CTCFL); CCCTC-binding factor (zinc finger protein)-like",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074856",
            "id": "NP_001074856"
        },
        {
            "name": "CTCF paralog",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprotkb/A2APF3/entry#names_and_taxonomy",
            "id": "A2APF3"
        },
        {
            "name": "CTCF-like protein",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprotkb/A2APF3/entry#names_and_taxonomy",
            "id": "A2APF3"
        },
        {
            "name": "transcriptional repressor CTCFL isoform 2",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074856",
            "id": "NP_001074856"
        }
    ],
    "function": [
        {
            "annotation": "Boris knockout eliminates AOM/DSS-induced in situ colorectal cancer by suppressing DNA damage repair and inflammation.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001074856",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074856"
                },
                {
                    "database": "PubMed",
                    "id": "36692143",
                    "url": "https://glygen.org/publication/PubMed/36692143"
                }
            ]
        },
        {
            "annotation": "CTCF and BORIS cooperate with additional Testis-specific transcriptional regulators to regulate gene expression in developing male gametes. Erratum:[Sci Rep. 2017 Aug 04;7:46891. PMID: 28776597] Publication Status: Online-Only",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001074856",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074856"
                },
                {
                    "database": "PubMed",
                    "id": "28145452",
                    "url": "https://glygen.org/publication/PubMed/28145452"
                }
            ]
        },
        {
            "annotation": "CTCFL and PRMT7 may play a role in male germline imprinted gene methylation.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001074856",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074856"
                },
                {
                    "database": "PubMed",
                    "id": "17048991",
                    "url": "https://glygen.org/publication/PubMed/17048991"
                }
            ]
        },
        {
            "annotation": "CTCFL expression is associated with cerebral vascular abnormalities.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001074856",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074856"
                },
                {
                    "database": "PubMed",
                    "id": "33756271",
                    "url": "https://glygen.org/publication/PubMed/33756271"
                }
            ]
        },
        {
            "annotation": "CTCFL/BORIS is a methylation-independent DNA-binding protein that preferentially binds to the paternal H19 differentially methylated region",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001074856",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074856"
                },
                {
                    "database": "PubMed",
                    "id": "18632606",
                    "url": "https://glygen.org/publication/PubMed/18632606"
                }
            ]
        },
        {
            "annotation": "DNA damage-induced and ATR/Rfx1-mediated increase of miR-709 expression in exposed testes may be a protective mechanism that effectively decreases a cellular level of BORIS to prevent massive aberrant erasure of DNA methylation after radiation exposure.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001074856",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074856"
                },
                {
                    "database": "PubMed",
                    "id": "19029807",
                    "url": "https://glygen.org/publication/PubMed/19029807"
                }
            ]
        },
        {
            "annotation": "Defining the relative and combined contribution of CTCF and CTCFL to genomic regulation. Erratum:[Genome Biol. 2020 Jun 2;21(1):133. PMID: 32487268] Publication Status: Online-Only",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001074856",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074856"
                },
                {
                    "database": "PubMed",
                    "id": "32393311",
                    "url": "https://glygen.org/publication/PubMed/32393311"
                }
            ]
        },
        {
            "annotation": "Testis-specific DNA binding protein responsible for insulator function, nuclear architecture and transcriptional control, which probably acts by recruiting epigenetic chromatin modifiers. Plays a key role in gene imprinting in male germline, by participating in the establishment of differential methylation at the IGF2/H19 imprinted control region (ICR). Directly binds the unmethylated H19 ICR and recruits the PRMT7 methyltransferase, leading to methylate histone H4 'Arg-3' to form H4R3sme2. This probably leads to recruit de novo DNA methyltransferases at these sites. Seems to act as tumor suppressor. In association with DNMT1 and DNMT3B, involved in activation of BAG1 gene expression by binding to its promoter. Required for dimethylation of H3 lysine 4 (H3K4me2) of MYC and BRCA1 promoters.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2APF3",
                    "url": "https://www.uniprot.org/uniprot/A2APF3#function"
                },
                {
                    "database": "PubMed",
                    "id": "17048991",
                    "url": "https://glygen.org/publication/PubMed/17048991"
                }
            ]
        },
        {
            "annotation": "The combined action of CTCF and its testis-specific paralog BORIS is essential for spermatogenesis. Publication Status: Online-Only",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001074856",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074856"
                },
                {
                    "database": "PubMed",
                    "id": "34158481",
                    "url": "https://glygen.org/publication/PubMed/34158481"
                }
            ]
        }
    ],
    "disease": [],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Mus musculus",
            "taxid": 10090,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2APF3",
                    "url": "https://www.uniprot.org/uniprot/A2APF3"
                }
            ],
            "common_name": "Mouse",
            "glygen_name": "Mouse",
            "reference_species": "Mus musculus [10090]"
        }
    ],
    "gene": [
        {
            "name": "Ctcfl",
            "url": "https://www.uniprot.org/uniprot/A2APF3",
            "locus": {
                "chromosome": "2",
                "start_pos": 172935402,
                "end_pos": 172961318,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSMUSG00000070495",
                        "url": "https://www.ensembl.org/id/ENSMUSG00000070495"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSMUSG00000070495",
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000070495",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "664799",
            "url": "https://www.ncbi.nlm.nih.gov/gene/664799",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "A2APF3",
            "url": "https://www.ebi.ac.uk/intact/interactors/id:A2APF3*",
            "database": "IntAct",
            "categories": [
                "Other"
            ]
        },
        {
            "id": "IPR013087",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR036236",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "mmu:664799",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:664799",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "3652571",
            "url": "http://www.informatics.jax.org/marker/MGI:3652571",
            "database": "MGI",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "LTCEMIF",
            "url": "https://omabrowser.org/oma/group/LTCEMIF/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "5398475at2759",
            "url": "http://www.orthodb.org/?query=5398475at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR24399",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24399",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR24399:SF23",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24399:SF23",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF00096",
            "url": "http://pfam.xfam.org/family/PF00096",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PR_A2APF3",
            "url": "http://purl.obolibrary.org/obo/PR_A2APF3",
            "database": "PRO",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "NP_001074856",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074856",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A2APF3",
            "url": "https://www.uniprot.org/uniprot/A2APF3",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A2APF3-1",
            "url": "https://www.uniprot.org/uniprot/A2APF3-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A2APF3-2",
            "url": "https://www.uniprot.org/uniprot/A2APF3-2",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MAAAEVPVPSGYFTQIKEQKLKPGDLEEEKEEDGVQRVEAQEGVVKEVEAENSCLLLEARAPVESDRRILTLQTVHLESQDVHLQGLGWLSVPHSEELSGTVPEAEGILQLPSVLWLDPEPQLSLQHCVTVSIPEELYPPEELQRIHFHLLRENVLMAEENPELTPDLDESTALKKPEEDEKDQLPPQGETDKREERLLLLEMKPKEGKDDEIVLTISHLSLEEQQDPPAANQTSVPGAKAAKPKRRRQTKGKPQSFQCDTCPFTSSKLSTFNRHIKIHSNERPHLCHLCLKAFRTVTLLRNHVNTHTGTRPHKCRDCDMAFVTSGELVRHRRYKHTYEKPFKCSLCKYASVEASKMKRHIRSHTGERPFQCCQCAYASRDSYKLKRHMRTHSGEKPYECPTCHVRFTQSGTMKIHIAQKHGENVPKYECPHCATIIARKSDLRVHLRNLHSQSPEEMKCRYCPAGFHERYALIQHQRTHKNEKKFKCKQCDYACKQERCLKAHMRMHTGEKPFSCLACNKHFRQKQLLTVHLRKYHDPNFVPNLHLCLKCDKRFSRWSNLQRHRKKCDPEHETLAPNKDRRPVTRTQASEGEAGHKEGEPQCPGEQALGHQGEAAGSQSPDHGLTCEIIFNMMDK",
        "length": 636,
        "header": "sp|A2APF3-1|CTCFL_MOUSE Isoform 1 of Transcriptional repressor CTCFL  OS=Mus musculus OX=10090 GN=Ctcfl PE=1 SV=1 CANONICAL=A2APF3-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A2APF3-1",
            "url": "https://www.uniprot.org/uniprotkb/A2APF3/entry#A2APF3-1",
            "sequence": {
                "sequence": "MAAAEVPVPSGYFTQIKEQKLKPGDLEEEKEEDGVQRVEAQEGVVKEVEAENSCLLLEARAPVESDRRILTLQTVHLESQDVHLQGLGWLSVPHSEELSGTVPEAEGILQLPSVLWLDPEPQLSLQHCVTVSIPEELYPPEELQRIHFHLLRENVLMAEENPELTPDLDESTALKKPEEDEKDQLPPQGETDKREERLLLLEMKPKEGKDDEIVLTISHLSLEEQQDPPAANQTSVPGAKAAKPKRRRQTKGKPQSFQCDTCPFTSSKLSTFNRHIKIHSNERPHLCHLCLKAFRTVTLLRNHVNTHTGTRPHKCRDCDMAFVTSGELVRHRRYKHTYEKPFKCSLCKYASVEASKMKRHIRSHTGERPFQCCQCAYASRDSYKLKRHMRTHSGEKPYECPTCHVRFTQSGTMKIHIAQKHGENVPKYECPHCATIIARKSDLRVHLRNLHSQSPEEMKCRYCPAGFHERYALIQHQRTHKNEKKFKCKQCDYACKQERCLKAHMRMHTGEKPFSCLACNKHFRQKQLLTVHLRKYHDPNFVPNLHLCLKCDKRFSRWSNLQRHRKKCDPEHETLAPNKDRRPVTRTQASEGEAGHKEGEPQCPGEQALGHQGEAAGSQSPDHGLTCEIIFNMMDK",
                "length": 636,
                "header": "sp|A2APF3-1|CTCFL_MOUSE Isoform 1 of Transcriptional repressor CTCFL  OS=Mus musculus OX=10090 GN=Ctcfl PE=1 SV=1 CANONICAL=A2APF3-1"
            },
            "locus": {
                "chromosome": "2",
                "start_pos": 172960581,
                "end_pos": 172936463,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000094287.10",
                        "url": "https://www.ensembl.org/id/ENSMUST00000094287.10"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000091845.4",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000091845.4"
                    }
                ]
            }
        },
        {
            "isoform_ac": "A2APF3-2",
            "url": "https://www.uniprot.org/uniprotkb/A2APF3/entry#A2APF3-2",
            "sequence": {
                "sequence": "MAAAEVPVPSGYFTQIKEQKLKPGDLEEEKEEDGVQRVEAQEGVVKEVEAENSCLLLEARAPVESDRRILTLQTVHLESQDVHLQGLGWLSVPHSEELSGTVPEAEGILQLPSVLWLDPEPQLSLQHCVTVSIPEELYPPEELQRIHFHLLRENVLMAEENPELTPDLDESTALKKPEEDEKDQLPPQGETDKREERLLLLEMKPKEGKDDEIVLTISHLSLEEQQDPPAANQTSVPGAKAAKPKRRRQTKGKPQSFQCDTCPFTSSKLSTFNRHIKIHSNERPHLCHLCLKAFRTVTLLRNHVNTHTGTRPHKCRDCDMAFVTSGELVRHRRYKHTYEKPFKCSLCKYASVEASKMKRHIRSHTGERPFQCCQCAYASRDSYKLKRHMRTHSGEKPYECPTCHVRFTQSGTMKIHIAQKHGENVPKYECPHCATIIARKSDLRVHLRNLHSQSPEEMKCRYCPAGFHERYALIQHQRTHKNEKKFKCKQCDYACKQERCLKAHMRMHTGEKPFSCLACNKHFRQKQLLTVHLRKYHDPNFVPNLHLCLKCDKRFSRWSNLQRHRKKCDPEHETLAPNKDRRPVTRTQASEGEAGHKEDVATQESATSGEPQCPGEQALGHQGEAAGSQSPDHGLTCEIIFNMMDK",
                "length": 646,
                "header": "sp|A2APF3-2|CTCFL_MOUSE Isoform 2 of Transcriptional repressor CTCFL  OS=Mus musculus OX=10090 GN=Ctcfl PE=1 SV=1 CANONICAL=A2APF3-1"
            },
            "locus": {}
        }
    ],
    "glycosylation": [],
    "phosphorylation": [
        {
            "start_pos": 587,
            "end_pos": 587,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Thr",
            "comment": "",
            "evidence": [
                {
                    "database": "iPTMnet",
                    "id": "A2APF3",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2APF3"
                }
            ],
            "site_lbl": "Thr587"
        }
    ],
    "glycation": [],
    "keywords": [],
    "publication": [
        {
            "title": "BORIS, a novel male germ-line-specific protein associated with epigenetic reprogramming events, shares the same 11-zinc-finger domain with CTCF, the insulator protein involved in reading imprinting marks in the soma.",
            "journal": "Proc. Natl. Acad. Sci. U.S.A.",
            "date": "2002",
            "authors": "Loukinov Dmitri I, Pugacheva Elena, Vatolin Sergei, Pack Svetlana D, Moon Hanlim, Chernukhin Igor, Mannan Poonam, Larsson Erik, Kanduri Chandrasekhar, Vostrov Alexander A, Cui Hengmi, Niemitz Emily L, Rasko John E J, Docquier France M, Kistler Malathi, Breen Joseph J, Zhuang Zhengping, Quitschke Wolfgang W, Renkawitz Rainer, Klenova Elena M, Feinberg Andrew P, Ohlsson Rolf, Morse Herbert C, Lobanenkov Victor V",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2APF3",
                    "url": "https://www.uniprot.org/uniprot/A2APF3"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "12011441",
                    "url": "https://glygen.org/publication/PubMed/12011441"
                }
            ]
        },
        {
            "title": "The testis-specific factor CTCFL cooperates with the protein methyltransferase PRMT7 in H19 imprinting control region methylation.",
            "journal": "PLoS biology",
            "date": "2006",
            "authors": "Jelinic P, Stehle JC, Shaw P",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2APF3",
                    "url": "https://www.uniprot.org/uniprot/A2APF3"
                },
                {
                    "database": "RefSeq",
                    "id": "NP_001074856",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074856"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "17048991",
                    "url": "https://glygen.org/publication/PubMed/17048991"
                }
            ]
        },
        {
            "title": "CTCFL/BORIS is a methylation-independent DNA-binding protein that preferentially binds to the paternal H19 differentially methylated region.",
            "journal": "Cancer research",
            "date": "2008",
            "authors": "Nguyen P, Cui H, Bisht KS, Sun L, Patel K, Lee RS, Kugoh H, Oshimura M, Feinberg AP, Gius D",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001074856",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074856"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "18632606",
                    "url": "https://glygen.org/publication/PubMed/18632606"
                }
            ]
        },
        {
            "title": "DNA damage-induced upregulation of miR-709 in the germline downregulates BORIS to counteract aberrant DNA hypomethylation.",
            "journal": "Cell cycle (Georgetown, Tex.)",
            "date": "2008",
            "authors": "Tamminga J, Kathiria P, Koturbash I, Kovalchuk O",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001074856",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074856"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "19029807",
                    "url": "https://glygen.org/publication/PubMed/19029807"
                }
            ]
        },
        {
            "title": "Testis-specific transcriptional regulators selectively occupy BORIS-bound CTCF target regions in mouse male germ cells.",
            "journal": "Scientific reports",
            "date": "2017",
            "authors": "Rivero-Hinojosa S, Kang S, Lobanenkov VV, Zentner GE",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001074856",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074856"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "28145452",
                    "url": "https://glygen.org/publication/PubMed/28145452"
                }
            ]
        },
        {
            "title": "Defining the relative and combined contribution of CTCF and CTCFL to genomic regulation.",
            "journal": "Genome biology",
            "date": "2020",
            "authors": "Nishana M, Ha C, Rodriguez-Hernaez J, Ranjbaran A, Chio E, Nora EP, Badri SB, Kloetgen A, Bruneau BG, Tsirigos A, Skok JA",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001074856",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074856"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "32393311",
                    "url": "https://glygen.org/publication/PubMed/32393311"
                }
            ]
        },
        {
            "title": "CTCFL expression is associated with cerebral vascular abnormalities.",
            "journal": "Tissue & cell",
            "date": "2021",
            "authors": "Sati L, Soygur B, Goksu E, Bassorgun CI, McGrath J",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001074856",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074856"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "33756271",
                    "url": "https://glygen.org/publication/PubMed/33756271"
                }
            ]
        },
        {
            "title": "The combined action of CTCF and its testis-specific paralog BORIS is essential for spermatogenesis.",
            "journal": "Nature communications",
            "date": "2021",
            "authors": "Rivero-Hinojosa S, Pugacheva EM, Kang S, Mendez-Catala CF, Kovalchuk AL, Strunnikov AV, Loukinov D, Lee JT, Lobanenkov VV",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001074856",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074856"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "34158481",
                    "url": "https://glygen.org/publication/PubMed/34158481"
                }
            ]
        },
        {
            "title": "Boris knockout eliminates AOM/DSS-induced in situ colorectal cancer by suppressing DNA damage repair and inflammation.",
            "journal": "Cancer science",
            "date": "2023-01-24",
            "authors": "Zuo Bo-Wen, Yao Wan-Xin, Fang Meng-Die, Ren Juan, Tu Ling-Lan, Fan Run-Jie, Zhang Yan-Mei",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001074856",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074856"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "36692143",
                    "url": "https://glygen.org/publication/PubMed/36692143"
                }
            ]
        }
    ],
    "pathway": [
        {
            "id": "mmu:664799",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:664799",
            "resource": "KEGG Pathway"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "A0A8W4F9J4-1",
            "protein_name": "CCCTC-binding factor like",
            "gene_name": "CTCFL",
            "tax_id": 9823,
            "organism": "Sus scrofa",
            "sequence": {
                "sequence": "MAGAELSVVPKQFTQIKEPELMLEKVLEEEQKEDGVCRVKGHPGSAELEAGSTHGALQANIQEEELELVLATPEDNEKHIVTLQSVHFTSEDGALQELGWLEEGQVGVQPAGSGLPSLVWLGEGSQQSLHQCVAISIQEEVYSMPELERLQFQVLEENATPPGEDSRSAVSLAGSTESIKLDTGQKEEQLLVEGGLSEKAEEQFFLVEARPGEEGRDEIVLTISNFTVDEPETHPAAGEAPVEKADETHSQKKTKEVKRTFQCDICVFTSSRMSSFNRHMKTHTSEKPHVCHLCLKAFRTVTLLRNHINTHTGTRPYKCGDCDMAFVTSGELVRHRRYKHTHEKPFKCSMCKYASVEASKLKRHIRSHTGERPFQCPLCSYASKDTYKLKRHMRTHSGEKPYECHICHARFTQSGTMKIHVLQKHSENVPKYQCPHCDTIIARKSDLRVHLRNLHTYKAAEMKCRYCSATFHERYALIQHQKTHKNEKRFKCEHCSYACKQERHMTVHVRTHTGEKPFACLSCDKCFRQKQLLNVHLKKYHDTNFIPTVYECPRCGKGFSRWNNMKRHSEKCDSEQEKPAPSEKGRRVKKRKPAVPKEAATTRYLVVNGAEAAAEETALMSRAPSLGGLVPIDLGEAAAGSEDLDEDLTCEMILAVMDK",
                "length": 659
            },
            "evidence": [
                {
                    "id": "A2APF3",
                    "url": "https://omabrowser.org/oma/group/A2APF3/",
                    "database": "OMA"
                }
            ],
            "glygen_name": "Pig",
            "common_name": "Pig"
        },
        {
            "uniprot_canonical_ac": "D3ZQ48-1",
            "protein_name": "CCCTC-binding factor like",
            "gene_name": "Ctcfl1",
            "tax_id": 10116,
            "organism": "Rattus norvegicus",
            "sequence": {
                "sequence": "MAAAEVPVASGHFTQIKEQKLKPGDLEEEKEEGGVQRGEAQEGAVEEAEAEPQELPSRAPVESDRRILTLQTLHLTSQDVHLQGLGWLSVPHSEELSMTVPQAESILQLPSVLWLDPEPPLSLQHCVTVSIPEELYPPEMLELRHFHLLRENVPEDDEENQESTSNLEESTAPKKPEEDEKDQLLPQGGTDKKEERFLFVEMKPREGKDEIVLTISHLSLEEQQDPPAAKHTSAPGAKAAKPKPQRQTKGRPRTFQCDTCPFTSSKLSTFNRHIKIHSDERPHLCHLCLKSFRTVTLLRNHVNTHTGTRPYKCGDCDMAFVTSGELVRHRRYKHTHEKPFKCSLCKYASVEASKLKRHIRSHTGERPFQCSQCAYASKDTYKLKRHMRTHSGEKPYECPTCHARFTQSGTMKIHIAQKHGENVPKHECPHCATIIARKSDLRVHLRNLHGHSPEEIKCRYCPAAFHERYALLQHQRTHKNEKKFKCKQCDYACKQERCLTAHMRTHTGERPFSCLTCNKHFRQKQLLTVHLRKYHDPSFVPSVHLCLKCGKGFSRWSNLQRHRKKCDPEHEKSAPSRNGRPVTRAQASEEGAEHDKDVATQESATSGEPRPPEEQALGHQGESAAGSPSPDQGLTCEMIFNMMDK",
                "length": 645
            },
            "evidence": [
                {
                    "id": "46374486",
                    "url": "http://www.informatics.jax.org/homology/46374486",
                    "database": "MGI"
                },
                {
                    "id": "A2APF3",
                    "url": "https://omabrowser.org/oma/group/A2APF3/",
                    "database": "OMA"
                }
            ],
            "glygen_name": "Rat",
            "common_name": "Rat"
        },
        {
            "uniprot_canonical_ac": "Q8NI51-1",
            "protein_name": "Transcriptional repressor CTCFL",
            "gene_name": "CTCFL",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MAATEISVLSEQFTKIKELELMPEKGLKEEEKDGVCREKDHRSPSELEAERTSGAFQDSVLEEEVELVLAPSEESEKYILTLQTVHFTSEAVELQDMSLLSIQQQEGVQVVVQQPGPGLLWLEEGPRQSLQQCVAISIQQELYSPQEMEVLQFHALEENVMVASEDSKLAVSLAETTGLIKLEEEQEKNQLLAERTKEQLFFVETMSGDERSDEIVLTVSNSNVEEQEDQPTAGQADAEKAKSTKNQRKTKGAKGTFHCDVCMFTSSRMSSFNRHMKTHTSEKPHLCHLCLKTFRTVTLLRNHVNTHTGTRPYKCNDCNMAFVTSGELVRHRRYKHTHEKPFKCSMCKYASVEASKLKRHVRSHTGERPFQCCQCSYASRDTYKLKRHMRTHSGEKPYECHICHTRFTQSGTMKIHILQKHGENVPKYQCPHCATIIARKSDLRVHMRNLHAYSAAELKCRYCSAVFHERYALIQHQKTHKNEKRFKCKHCSYACKQERHMTAHIRTHTGEKPFTCLSCNKCFRQKQLLNAHFRKYHDANFIPTVYKCSKCGKGFSRWINLHRHSEKCGSGEAKSAASGKGRRTRKRKQTILKEATKGQKEAAKGWKEAANGDEAAAEEASTTKGEQFPGEMFPVACRETTARVKEEVDEGVTCEMLLNTMDK",
                "length": 663
            },
            "evidence": [
                {
                    "id": "46374486",
                    "url": "http://www.informatics.jax.org/homology/46374486",
                    "database": "MGI"
                }
            ],
            "glygen_name": "Human",
            "common_name": "Human"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Molecular Function",
                "total": 8,
                "go_terms": [
                    {
                        "name": "chromatin insulator sequence binding",
                        "id": "GO:0043035",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043035",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2APF3",
                                "url": "https://www.uniprot.org/uniprot/A2APF3"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "DNA binding",
                        "id": "GO:0003677",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2APF3",
                                "url": "https://www.uniprot.org/uniprot/A2APF3"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "metal ion binding",
                        "id": "GO:0046872",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2APF3",
                                "url": "https://www.uniprot.org/uniprot/A2APF3"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "transcription cis-regulatory region binding",
                        "id": "GO:0000976",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000976",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2APF3",
                                "url": "https://www.uniprot.org/uniprot/A2APF3"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding",
                        "id": "GO:0000978",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2APF3",
                                "url": "https://www.uniprot.org/uniprot/A2APF3"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "histone binding",
                        "id": "GO:0042393",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042393",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2APF3",
                                "url": "https://www.uniprot.org/uniprot/A2APF3"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "sequence-specific DNA binding",
                        "id": "GO:0043565",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043565",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2APF3",
                                "url": "https://www.uniprot.org/uniprot/A2APF3"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "DNA-binding transcription activator activity, RNA polymerase II-specific",
                        "id": "GO:0001228",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001228",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2APF3",
                                "url": "https://www.uniprot.org/uniprot/A2APF3"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Cellular Component",
                "total": 6,
                "go_terms": [
                    {
                        "name": "nucleus",
                        "id": "GO:0005634",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2APF3",
                                "url": "https://www.uniprot.org/uniprot/A2APF3"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "nucleoplasm",
                        "id": "GO:0005654",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2APF3",
                                "url": "https://www.uniprot.org/uniprot/A2APF3"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cytoplasm",
                        "id": "GO:0005737",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2APF3",
                                "url": "https://www.uniprot.org/uniprot/A2APF3"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cytosol",
                        "id": "GO:0005829",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2APF3",
                                "url": "https://www.uniprot.org/uniprot/A2APF3"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "nuclear body",
                        "id": "GO:0016604",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016604",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2APF3",
                                "url": "https://www.uniprot.org/uniprot/A2APF3"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "chromosome",
                        "id": "GO:0005694",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005694",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2APF3",
                                "url": "https://www.uniprot.org/uniprot/A2APF3"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Biological Process",
                "total": 7,
                "go_terms": [
                    {
                        "name": "regulation of transcription by RNA polymerase II",
                        "id": "GO:0006357",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2APF3",
                                "url": "https://www.uniprot.org/uniprot/A2APF3"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "positive regulation of gene expression",
                        "id": "GO:0010628",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010628",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2APF3",
                                "url": "https://www.uniprot.org/uniprot/A2APF3"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "positive regulation of transcription by RNA polymerase II",
                        "id": "GO:0045944",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2APF3",
                                "url": "https://www.uniprot.org/uniprot/A2APF3"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "positive regulation of DNA-templated transcription",
                        "id": "GO:0045893",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045893",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2APF3",
                                "url": "https://www.uniprot.org/uniprot/A2APF3"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "transcription initiation-coupled chromatin remodeling",
                        "id": "GO:0045815",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045815",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2APF3",
                                "url": "https://www.uniprot.org/uniprot/A2APF3"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "genomic imprinting",
                        "id": "GO:0071514",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071514",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2APF3",
                                "url": "https://www.uniprot.org/uniprot/A2APF3"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "establishment of protein localization to chromatin",
                        "id": "GO:0071169",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071169",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2APF3",
                                "url": "https://www.uniprot.org/uniprot/A2APF3"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            }
        ]
    },
    "pro_annotation": [],
    "site_annotation": [
        {
            "start_pos": 232,
            "end_pos": 234,
            "annotation": "n_glycosylation_sequon"
        }
    ],
    "ptm_annotation": [],
    "interactions": [],
    "reactions": [],
    "reaction_participants": [],
    "reaction_enzymes": [],
    "biomarkers": [],
    "synthesized_glycans": [],
    "enzyme_annotation": [],
    "cluster_types": [
        {
            "name": "isoformset.uniprotkb",
            "label": "Isoforms"
        },
        {
            "name": "homologset.oma",
            "label": "OMA Homologs"
        },
        {
            "name": "homologset.mgi",
            "label": "MGI Homologs"
        }
    ],
    "sequence_features": {
        "n_linked_sites": [],
        "o_linked_sites": [],
        "snv_sites": [],
        "glycation_sites": [],
        "phosphorylation_sites": [
            587
        ],
        "sequon_annotation_sites": [
            {
                "start_pos": 232,
                "end_pos": 234
            }
        ]
    },
    "section_stats": [
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            ],
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        {
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        {
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        {
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        {
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}