{ "uniprot_canonical_ac": "A2AJL3-1", "uniprot_ac": "A2AJL3", "uniprot_id": "FGGY_MOUSE", "mass": { "chemical_mass": 60336.0, "monoisotopic_mass": 60336.0 }, "refseq": { "ac": "NP_001106883", "name": "FGGY carbohydrate kinase domain-containing protein isoform a", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106883" }, "gene_names": [ { "name": "Fggy", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A2AJL3", "id": "A2AJL3" }, { "name": "2310009E04Rik", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106883", "id": "NP_001106883" }, { "name": "Fggy", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106883", "id": "NP_001106883" } ], "protein_names": [ { "name": "FGGY carbohydrate kinase domain-containing protein", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprotkb/A2AJL3/entry#names_and_taxonomy", "id": "A2AJL3" }, { "name": "2.7.1.47", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A2AJL3/entry#names_and_taxonomy", "id": "A2AJL3" }, { "name": "D-ribulokinase FGGY", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A2AJL3/entry#names_and_taxonomy", "id": "A2AJL3" }, { "name": "FGGY carbohydrate kinase domain-containing protein isoform a", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106883", "id": "NP_001106883" }, { "name": "FGGY carbohydrate kinase domain-containing protein; D-ribulokinase FGGY", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106883", "id": "NP_001106883" } ], "function": [ { "annotation": "Catalyzes ATP-dependent phosphorylation of D-ribulose at C-5 to form D-ribulose 5-phosphate. Postulated to function in a metabolite repair mechanism by preventing toxic accumulation of free D-ribulose formed by non-specific phosphatase activities. Alternatively, may play a role in regulating D-ribulose 5-phosphate recycling in the pentose phosphate pathway. Can phosphorylate ribitol with low efficiency.", "evidence": [ { "database": "UniProtKB", "id": "A2AJL3", "url": "https://www.uniprot.org/uniprot/A2AJL3#function" }, { "database": "UniProtKB", "id": "Q96C11", "url": "https://www.uniprot.org/uniprot/Q96C11#function" } ] }, { "annotation": "FGGY carbohydrate kinase domain containing is expressed and alternatively spliced in skeletal muscle and attenuates MAP kinase and Akt signaling.", "evidence": [ { "database": "RefSeq", "id": "NP_001106883", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106883" }, { "database": "PubMed", "id": "34280510", "url": "https://glygen.org/publication/PubMed/34280510" } ] }, { "annotation": "The strength of Fggy mRNA expression significantly correlated with increased whole body weight and gonadal fat weight of males but not females.", "evidence": [ { "database": "RefSeq", "id": "NP_001106883", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106883" }, { "database": "PubMed", "id": "29220483", "url": "https://glygen.org/publication/PubMed/29220483" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "A2AJL3", "url": "https://www.uniprot.org/uniprot/A2AJL3" } ], "common_name": "Mouse", "glygen_name": "Mouse", "reference_species": "Mus musculus [10090]" } ], "gene": [ { "name": "Fggy", "url": "https://www.uniprot.org/uniprot/A2AJL3", "locus": { "chromosome": "4", "start_pos": 95815176, "end_pos": 95445744, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000028573", "url": "https://www.ensembl.org/id/ENSMUSG00000028573" } ] } } ], "crossref": [ { "id": "ENSMUSG00000028573", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000028573", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd07782", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07782", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "75578", "url": "https://www.ncbi.nlm.nih.gov/gene/75578", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000577", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000577", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006003", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006003", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018484", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018484", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018485", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018485", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043129", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043129", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "mmu:75578", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:75578", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "1922828", "url": "http://www.informatics.jax.org/marker/MGI:1922828", "database": "MGI", "categories": [ "Organism-specific" ] }, { "id": "HKAMWHE", "url": "https://omabrowser.org/oma/group/HKAMWHE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "120218at2759", "url": "http://www.orthodb.org/?query=120218at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR43435", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43435", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR43435:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43435:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00370", "url": "http://pfam.xfam.org/family/PF00370", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF02782", "url": "http://pfam.xfam.org/family/PF02782", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_A2AJL3", "url": "http://purl.obolibrary.org/obo/PR_A2AJL3", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_001106883", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106883", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "17601", "url": "https://www.rhea-db.org/rhea/17601", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A2AJL3", "url": "https://www.uniprot.org/uniprot/A2AJL3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A2AJL3-1", "url": "https://www.uniprot.org/uniprot/A2AJL3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A2AJL3-2", "url": "https://www.uniprot.org/uniprot/A2AJL3-2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A2AJL4", "url": "https://www.uniprot.org/uniprot/A2AJL4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A2AJL4-1", "url": "https://www.uniprot.org/uniprot/A2AJL4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "B1AY71", "url": "https://www.uniprot.org/uniprot/B1AY71", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "B1AY71-1", "url": "https://www.uniprot.org/uniprot/B1AY71-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "B7ZCH9", "url": "https://www.uniprot.org/uniprot/B7ZCH9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "B7ZCH9-1", "url": "https://www.uniprot.org/uniprot/B7ZCH9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "D6RG41", "url": "https://www.uniprot.org/uniprot/D6RG41", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "D6RG41-1", "url": "https://www.uniprot.org/uniprot/D6RG41-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "D6RHR3", "url": "https://www.uniprot.org/uniprot/D6RHR3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "D6RHR3-1", "url": "https://www.uniprot.org/uniprot/D6RHR3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6V664", "url": "https://www.uniprot.org/uniprot/F6V664", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6V664-1", "url": "https://www.uniprot.org/uniprot/F6V664-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6WQK7", "url": "https://www.uniprot.org/uniprot/F6WQK7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6WQK7-1", "url": "https://www.uniprot.org/uniprot/F6WQK7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F7ANG8", "url": "https://www.uniprot.org/uniprot/F7ANG8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F7ANG8-1", "url": "https://www.uniprot.org/uniprot/F7ANG8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "H3BJ80", "url": "https://www.uniprot.org/uniprot/H3BJ80", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "H3BJ80-1", "url": "https://www.uniprot.org/uniprot/H3BJ80-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MMSGRDQEPSRYYVGIDVGTGSVRAALVDQRGLLLAFAEQPIKKWEPQFNHHEQSSEDIWAACCLVTKEVVQGIDAHRIRGLGFDATCSLVVLDKEFHPLPVNHEGDSSRNVIMWLDHRAVSQVHRINETKHRVLQYVGGVMSVEMQAPKLLWLKENLREICWDKAGHFFDLPDFLSWKATGVTARSLCSLVCKWTYSAEKGWDDSFWKMIGLEDLIDDNYSKIGNLVLLPGAALGIGLTPEAARELGLPSGIAVAASLIDAHAGGLGVIGADVRGHGLTCEGQPVTSRLAVICGTSSCHMGISKDPVFVPGVWGPYYSAMVPGFWLNEGGQSVTGKLIDHMVQGHPAFPELQAKATARCQSIYAYLNSHLDLIKKAQPVGFLTVDLHVWPDFHGNRSPLADLTLKGMVTGLTLSQDLDDLAILYLATVQAIAFGTRFIIETMEAAGHSLSTLFLCGGLSKNPLFVQMHADITGMPVVLSQEVESVLVGAAILGACASGDFTSVQEAMARMSKVGKVVFPEHADKKYYDKKYQVFLRMVEHQKEYSAIMNGS", "length": 552, "header": "sp|A2AJL3-1|FGGY_MOUSE Isoform 1 of FGGY carbohydrate kinase domain-containing protein OS=Mus musculus OX=10090 GN=Fggy PE=1 SV=1 CANONICAL=A2AJL3-1" }, "isoforms": [ { "isoform_ac": "A2AJL3-1", "url": "https://www.uniprot.org/uniprotkb/A2AJL3/entry#A2AJL3-1", "sequence": { "sequence": "MMSGRDQEPSRYYVGIDVGTGSVRAALVDQRGLLLAFAEQPIKKWEPQFNHHEQSSEDIWAACCLVTKEVVQGIDAHRIRGLGFDATCSLVVLDKEFHPLPVNHEGDSSRNVIMWLDHRAVSQVHRINETKHRVLQYVGGVMSVEMQAPKLLWLKENLREICWDKAGHFFDLPDFLSWKATGVTARSLCSLVCKWTYSAEKGWDDSFWKMIGLEDLIDDNYSKIGNLVLLPGAALGIGLTPEAARELGLPSGIAVAASLIDAHAGGLGVIGADVRGHGLTCEGQPVTSRLAVICGTSSCHMGISKDPVFVPGVWGPYYSAMVPGFWLNEGGQSVTGKLIDHMVQGHPAFPELQAKATARCQSIYAYLNSHLDLIKKAQPVGFLTVDLHVWPDFHGNRSPLADLTLKGMVTGLTLSQDLDDLAILYLATVQAIAFGTRFIIETMEAAGHSLSTLFLCGGLSKNPLFVQMHADITGMPVVLSQEVESVLVGAAILGACASGDFTSVQEAMARMSKVGKVVFPEHADKKYYDKKYQVFLRMVEHQKEYSAIMNGS", "length": 552, "header": "sp|A2AJL3-1|FGGY_MOUSE Isoform 1 of FGGY carbohydrate kinase domain-containing protein OS=Mus musculus OX=10090 GN=Fggy PE=1 SV=1 CANONICAL=A2AJL3-1" }, "locus": { "chromosome": "4", "start_pos": 95815038, "end_pos": 95473481, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000079223.11", "url": "https://www.ensembl.org/id/ENSMUST00000079223.11" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000078216.5", "url": "https://www.ensembl.org/id/ENSMUSP00000078216.5" } ] } }, { "isoform_ac": "A2AJL3-2", "url": "https://www.uniprot.org/uniprotkb/A2AJL3/entry#A2AJL3-2", "sequence": { "sequence": "MMSGRDQEPSRYYVGIDVGTGSVRAALVDQRGLLLAFAEQPIKKWEPQFNHHEQSSEDIWAACCLVTKEVVQGIDAHRIRGLGFDATCSLVVLDKEFHPLPVNHEGDSSRNVIMWLDHRAVSQVHRINETKHRVLQYVGGVMSVEMQAPKLLWLKENLREICWDKAGHFFDLPDFLSWKATGVTARSLCSLVCKWTYSAEKGWDDSFWKMIGLEDLIDDNYSKIGNLVLLPGAALGIGLTPEAARELGLPSGIAVAASLIDAHAGGLGVIGADVRGHGLTCEGQPVTSRLAVICGTSSCHMGISKDPVFVPGVWGPYYSAMVPGFWLNEGGQSVTGKLIDHMVQGHPAFPELQAKATARNLQKHHGIHGDTPGIAKYELEVTSSKAF", "length": 387, "header": "sp|A2AJL3-2|FGGY_MOUSE Isoform 2 of FGGY carbohydrate kinase domain-containing protein OS=Mus musculus OX=10090 GN=Fggy PE=1 SV=1 CANONICAL=A2AJL3-1" }, "locus": { "chromosome": "4", "start_pos": 95709203, "end_pos": 95473481, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000043335.11", "url": "https://www.ensembl.org/id/ENSMUST00000043335.11" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000043460.5", "url": "https://www.ensembl.org/id/ENSMUSP00000043460.5" } ] } }, { "isoform_ac": "A2AJL4-1", "url": "https://www.uniprot.org/uniprotkb/A2AJL3/entry#A2AJL4-1", "sequence": { "sequence": "MMSGRDQEPSRYYVGIDVGTGSVRAALVDQRGLLLAFAEQPIKKWEPQFNHHEQSSEDIWAACCLVTKNLREICWDKAGHFFDLPDFLSWKATGVTARSLCSLVCKWTYSAEKGWDDSFWKMIGLEDLIDDNYSKIGNLVLLPGAALGIGLTPEAARELGLPSGIAVAASLIDAHAGGLGVIGADVRGHGLTCEGQPVTSRLAVICGTSSCHMGISKDPVFVPGVWGPYYSAMVPGFWLNEGGQSVTGKLIDHMVQGHPAFPELQAKATARCQSIYAYLNSHLDLIKKAQPVGFLTVDLHVWPDFHGNRSPLADLTLKGMVTGLTLSQDLDDLAILYLATVQAIAFGTRFIIETMEAAGHSLSTLFLCGGLSKNPLFVQMHADITGMPVVLSQEVESVLVGAAILGACASGDFTSVQEAMARMSKVGKVVFPEHADKKYYDKKYQVFLRMVEHQKEYSAIMNGS", "length": 464, "header": "tr|A2AJL4-1|FGGY_MOUSE Computationally mapped isoform of FGGY carbohydrate kinase domain-containing protein OS=Mus musculus OX=10090 GN=Fggy PE=1 SV=1 CANONICAL=A2AJL3-1" }, "locus": { "chromosome": "4", "start_pos": 95815038, "end_pos": 95473481, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000107091.11", "url": "https://www.ensembl.org/id/ENSMUST00000107091.11" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000102706.5", "url": "https://www.ensembl.org/id/ENSMUSP00000102706.5" } ] } }, { "isoform_ac": "B1AY71-1", "url": "https://www.uniprot.org/uniprotkb/A2AJL3/entry#B1AY71-1", "sequence": { "sequence": "MMSGRDQEPSRYYVGIDVGTGSVRAALVDQRGLLLAFAEQPIKKWEPQFNHHEQSSEDIWAACCLVTKEVVQGIDAHRI", "length": 79, "header": "tr|B1AY71-1|FGGY_MOUSE Computationally mapped isoform of FGGY carbohydrate kinase domain-containing protein OS=Mus musculus OX=10090 GN=Fggy PE=1 SV=1 CANONICAL=A2AJL3-1" }, "locus": { "chromosome": "4", "start_pos": 95485892, "end_pos": 95473481, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000150830.2", "url": "https://www.ensembl.org/id/ENSMUST00000150830.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000115546.2", "url": "https://www.ensembl.org/id/ENSMUSP00000115546.2" } ] } }, { "isoform_ac": "B7ZCH9-1", "url": "https://www.uniprot.org/uniprotkb/A2AJL3/entry#B7ZCH9-1", "sequence": { "sequence": "TSSCHMGISKDPVFVPGVWGPYYSAMVPGFWLNEGGQSVTGKLIDHMVQGHPAFPELQAKATARCQSIYAYLNSHLDLIKKAQPVGFLTVDLHVWPDFHGNRSPLADLTLKGMVTGLTLSQDLDDLAILYLATVQAIAACLWSCHKRWSLSSWELLFWVPVPQGTSLLCRRQWQG", "length": 175, "header": "tr|B7ZCH9-1|FGGY_MOUSE Computationally mapped isoform of FGGY carbohydrate kinase domain-containing protein OS=Mus musculus OX=10090 GN=Fggy PE=1 SV=1 CANONICAL=A2AJL3-1" }, "locus": { "chromosome": "4", "start_pos": 95811177, "end_pos": 95657746, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000130541.8", "url": "https://www.ensembl.org/id/ENSMUST00000130541.8" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000115688.2", "url": "https://www.ensembl.org/id/ENSMUSP00000115688.2" } ] } }, { "isoform_ac": "D6RG41-1", "url": "https://www.uniprot.org/uniprotkb/A2AJL3/entry#D6RG41-1", "sequence": { "sequence": "MMSGRDQEPSRYYVGIDVGTGVTARSLCSLVCKWTYSAEKGWDDSFWKMIGLEDLIDDNYSKIGNLVLLPGAALGIGLTPEAARELGLPSGIAVAASLIDAHAGGLGVIG", "length": 110, "header": "tr|D6RG41-1|FGGY_MOUSE Computationally mapped isoform of FGGY carbohydrate kinase domain-containing protein OS=Mus musculus OX=10090 GN=Fggy PE=1 SV=2 CANONICAL=A2AJL3-1" }, "locus": { "chromosome": "4", "start_pos": 95657673, "end_pos": 95473481, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000134012.9", "url": "https://www.ensembl.org/id/ENSMUST00000134012.9" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000115859.3", "url": "https://www.ensembl.org/id/ENSMUSP00000115859.3" } ] } }, { "isoform_ac": "D6RHR3-1", "url": "https://www.uniprot.org/uniprotkb/A2AJL3/entry#D6RHR3-1", "sequence": { "sequence": "MMSGRDQEPSRYYVGIDVGTGSVRAALVDQRGLLLAFAEQPIKKWEPQFNHHEQSSEDIWAACCLVTKGTPLETLSCGWTTGLSARSTGLMRPSTESFSMWVV", "length": 103, "header": "tr|D6RHR3-1|FGGY_MOUSE Computationally mapped isoform of FGGY carbohydrate kinase domain-containing protein OS=Mus musculus OX=10090 GN=Fggy PE=1 SV=1 CANONICAL=A2AJL3-1" }, "locus": { "chromosome": "4", "start_pos": 95489306, "end_pos": 95473481, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000131654.9", "url": "https://www.ensembl.org/id/ENSMUST00000131654.9" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000116264.3", "url": "https://www.ensembl.org/id/ENSMUSP00000116264.3" } ] } }, { "isoform_ac": "F6V664-1", "url": "https://www.uniprot.org/uniprotkb/A2AJL3/entry#F6V664-1", "sequence": { "sequence": "XCQSIYAYLNSHLDLIKKAQPVGFLTVDLHVWPDFHGNRSPLADLTLKGMVTGLTLSQDLDDLAILYLATVQAIAFGTRFIIETMEAAGHSLSTLFLCGGLSKNPLFVQMHADITGGNGKDEQSGESRVSGTC", "length": 133, "header": "tr|F6V664-1|FGGY_MOUSE Computationally mapped isoform of FGGY carbohydrate kinase domain-containing protein OS=Mus musculus OX=10090 GN=Fggy PE=1 SV=1 CANONICAL=A2AJL3-1" }, "locus": { "chromosome": "4", "start_pos": 95811216, "end_pos": 95710215, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000156223.2", "url": "https://www.ensembl.org/id/ENSMUST00000156223.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000118147.2", "url": "https://www.ensembl.org/id/ENSMUSP00000118147.2" } ] } }, { "isoform_ac": "F6WQK7-1", "url": "https://www.uniprot.org/uniprotkb/A2AJL3/entry#F6WQK7-1", "sequence": { "sequence": "XGAAILGACASGDFTSVQPAESWLLSVQEFTH", "length": 32, "header": "tr|F6WQK7-1|FGGY_MOUSE Computationally mapped isoform of FGGY carbohydrate kinase domain-containing protein OS=Mus musculus OX=10090 GN=Fggy PE=1 SV=1 CANONICAL=A2AJL3-1" }, "locus": { "chromosome": "4", "start_pos": 95790259, "end_pos": 95737862, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000142384.2", "url": "https://www.ensembl.org/id/ENSMUST00000142384.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000123407.2", "url": "https://www.ensembl.org/id/ENSMUSP00000123407.2" } ] } }, { "isoform_ac": "F7ANG8-1", "url": "https://www.uniprot.org/uniprotkb/A2AJL3/entry#F7ANG8-1", "sequence": { "sequence": "GVTARSLCSLVCKWTYSAEKGWDDSFWKMIGLEDLIDDNYSKIGRKVIRTEMFQEQLPTAHGLE", "length": 64, "header": "tr|F7ANG8-1|F7ANG8_MOUSE Computationally mapped isoform of FGGY carbohydrate kinase domain containing OS=Mus musculus OX=10090 GN=Fggy PE=1 SV=1 CANONICAL=A2AJL3-1" }, "locus": { "chromosome": "4", "start_pos": 95620559, "end_pos": 95511793, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000143742.3", "url": "https://www.ensembl.org/id/ENSMUST00000143742.3" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000117386.3", "url": "https://www.ensembl.org/id/ENSMUSP00000117386.3" } ] } }, { "isoform_ac": "H3BJ80-1", "url": "https://www.uniprot.org/uniprotkb/A2AJL3/entry#H3BJ80-1", "sequence": { "sequence": "MMSGRDQEPSRYYVGIDVGTGSVRAALVDQRGLLLAFAEQPIKKWEPQFNHHEQSSEDIWAACCLVTKEVVQGIDAH", "length": 77, "header": "tr|H3BJ80-1|H3BJ80_MOUSE Computationally mapped isoform of FGGY carbohydrate kinase domain containing OS=Mus musculus OX=10090 GN=Fggy PE=1 SV=1 CANONICAL=A2AJL3-1" }, "locus": { "chromosome": "4", "start_pos": 95485886, "end_pos": 95473481, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000177394.8", "url": "https://www.ensembl.org/id/ENSMUST00000177394.8" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000134881.2", "url": "https://www.ensembl.org/id/ENSMUSP00000134881.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Prenatal Exposure to Bisphenol A Disrupts Naturally Occurring Bimodal DNA Methylation at Proximal Promoter of fggy, an Obesity-Relevant Gene Encoding a Carbohydrate Kinase, in Gonadal White Adipose Tissues of CD-1 Mice.", "journal": "Endocrinology", "date": "2018", "authors": "Taylor JA, Shioda K, Mitsunaga S, Yawata S, Angle BM, Nagel SC, Vom Saal FS, Shioda T", "evidence": [ { "database": "RefSeq", "id": "NP_001106883", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106883" } ], "reference": [ { "type": "PubMed", "id": "29220483", "url": "https://glygen.org/publication/PubMed/29220483" } ] }, { "title": "FGGY carbohydrate kinase domain containing is expressed and alternatively spliced in skeletal muscle and attenuates MAP kinase and Akt signaling.", "journal": "Gene", "date": "2021", "authors": "Smith AL, Gjoka E, Izhar M, Novo KJ, Mason BC, De Las Casas A, Waddell DS", "evidence": [ { "database": "RefSeq", "id": "NP_001106883", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106883" } ], "reference": [ { "type": "PubMed", "id": "34280510", "url": "https://glygen.org/publication/PubMed/34280510" } ] } ], "pathway": [ { "id": "mmu:75578", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:75578", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "F1LSP9-1", "protein_name": "FGGY carbohydrate kinase domain containing", "gene_name": "Fggy", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MDIQTHVLTHMQQVLPLAEPLPSPVHGRGTMMSGGDQEPDHYYVGIDVGTGSVRAALVDQRGVLLAFAEQPIKKWEPQFNHHEQSSEDIWAACCRVTKEIVQGIDAHRIRGLGFDATCSLVVLDKEFHPLPVNREGDSSRNIIMWLDHRAVSQVHRINETKHSVLQYVGGVMSVEMQAPKLLWLKENLREICWDKAGHFFDLPDFLSWKATGVTARSLCSLVCKWTYSAEKGWDDSFWKMIGLEDLIGDNYNKIGNLVLPPGASLGSGLIPEAARELGLPSGIAVAASLIDAHAGGLGVIGADVRGHGLTCEGQPVTSRLAVICGTSSCHMGISKDPIFVPGVWGPYFSAMVPGFWLNEGGQSVTGKLIDHMVQSHPAFPELQAKATARCQSIYAYLNSHLDLIKKAQPVGFLTVDLHVWPDFHGNRSPLADLTLKGMVTGLTLSRDLDDLAVLYLATIQAIAFGTRFIIETMEAAGHSLSTLFLCGGLSKNPLFVQMHADITGMPVVLSQEVESVLVGAAILGACASGDFASVQEAMARMSKVGKVVFPERADKKYYDKKYQVFLRMVEHQKEYSAIMNGS", "length": 582 }, "evidence": [ { "id": "A2AJL3", "url": "https://omabrowser.org/oma/group/A2AJL3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q04585-1", "protein_name": "D-ribulokinase YDR109C", "gene_name": "", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MKSRKRQNNMQNETREPAVLSSQETSISRISPQDPEAKFYVGVDVGTGSARACVIDQSGNMLSLAEKPIKREQLISNFITQSSREIWNAVCYCVRTVVEESGVDPERVRGIGFDATCSLVVVSATNFEEIAVGPDFTNNDQNIILWMDHRAMKETEEINSSGDKCLKYVGGQMSVEMEIPKIKWLKNNLEAGIFQDCKFFDLPDYLTFKATGKENRSFCSAVCKQGFLPVGVEGSDIGWSKEFLNSIGLSELTKNDFERLGGSLREKKNFLTAGECISPLDKKAACQLGLTEHCVVSSGIIDAYAGWVGTVAAKPESAVKGLAETENYKKDFNGAIGRLAAVAGTSTCHILLSKNPIFVHGVWGPYRDVLARGFWAAEGGQSCTGVLLDHLITTHPAFTELSHMANLAGVSKFEYLNKILETLVEKRKVRSVISLAKHLFFYGDYHGNRSPIADPNMRACIIGQSMDNSIEDLAVMYLSACEFISQQTRQIIEVMLKSGHEINAIFMSGGQCRNSLLMRLLADCTGLPIVIPRYVDAAVVFGSALLGAAASEDFDYTREKRTLKGQKSSQTKTERFNDSYSSIQKLSMEDRNSTNGFVSPHNLQLSTPSAPAKINNYSLPICTQQPLDKTSEESSKDASLTVGQESLGEGRYNGTSFLWKVMQELTGNARIVNPNEKTHPDRILLDTKYQIFLDMIETQRKYRRMVDKVEGSFSR", "length": 715 }, "evidence": [ { "id": "A2AJL3", "url": "https://omabrowser.org/oma/group/A2AJL3/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q96C11-1", "protein_name": "FGGY carbohydrate kinase domain-containing protein", "gene_name": "FGGY", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSGGEQKPERYYVGVDVGTGSVRAALVDQSGVLLAFADQPIKNWEPQFNHHEQSSEDIWAACCVVTKKVVQGIDLNQIRGLGFDATCSLVVLDKQFHPLPVNQEGDSHRNVIMWLDHRAVSQVNRINETKHSVLQYVGGVMSVEMQAPKLLWLKENLREICWDKAGHFFDLPDFLSWKATGVTARSLCSLVCKWTYSAEKGWDDSFWKMIGLEDFVADNYSKIGNQVLPPGASLGNGLTPEAARDLGLLPGIAVAASLIDAHAGGLGVIGADVRGHGLICEGQPVTSRLAVICGTSSCHMGISKDPIFVPGVWGPYFSAMVPGFWLNEGGQSVTGKLIDHMVQGHAAFPELQVKATARCQSIYAYLNSHLDLIKKAQPVGFLTVDLHVWPDFHGNRSPLADLTLKGMVTGLKLSQDLDDLAILYLATVQAIALGTRFIIEAMEAAGHSISTLFLCGGLSKNPLFVQMHADITGMPVVLSQEVESVLVGAAVLGACASGDFASVQEAMAKMSKVGKVVFPRLQDKKYYDKKYQVFLKLVEHQKEYLAIMNDD", "length": 551 }, "evidence": [ { "id": "46362491", "url": "http://www.informatics.jax.org/homology/46362491", "database": "MGI" }, { "id": "A2AJL3", "url": "https://omabrowser.org/oma/group/A2AJL3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9VZJ8-1", "protein_name": "RH40737p", "gene_name": "Dmel\\CG11594", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MSSGPFFVGVDVGTGSARAALVACDGRVLEQAVQTIQTWNPEPGYYNQSSDNIWQSICQVVKKVIGGVDKSKVKGIGFDATCSLVVLGPQGSPLTVSKSGEAEQNIILWMDHRAEQETQEINAFKHSLLKYVGGQVSLEMEVPKLLWLKRNLSQTFGNIWRVFDLPDFLTWRATGVDTRSLCSVVCKWNYDAANGSWNKEFLKQADLEELTQNNFEKLGSDVQPPGRTVGKGLTAKAAGELGLSAGTVVSTSLIDAHAGALGMFGCRSKESKGADDVQGKMALIAGTSTCHMSITRKACFAQGVWGPYQDAIIPGYFLNEGGQSIAGHLLDHVLKSHESYAELKSQLGEDKFIYQHLNKLLPELAAARGLSQVGCLTQDVHVWPDLHGNRSPIADPTLRGVITGLDMTRGTESLAIKYLAFVQALAYGTRHIIENLYQYGRAPFQTLLFCGGLAKNPLYVQCHADICNLPALIPDEQEMVLVGAAALGAAASGHFDSLESASKSMGGTGQLVKPNAETLEFHNRKYKVFLQLLENQRQYRRIMQADTK", "length": 548 }, "evidence": [ { "id": "A2AJL3", "url": "https://omabrowser.org/oma/group/A2AJL3/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "carbohydrate metabolic process", "id": "GO:0005975", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005975", "evidence": [ { "database": "UniProtKB", "id": "A2AJL3", "url": "https://www.uniprot.org/uniprot/A2AJL3" } ], "pmid": "" }, { "name": "neuron cellular homeostasis", "id": "GO:0070050", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070050", "evidence": [ { "database": "UniProtKB", "id": "A2AJL3", "url": "https://www.uniprot.org/uniprot/A2AJL3" } ], "pmid": "" }, { "name": "pentose metabolic process", "id": "GO:0019321", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019321", "evidence": [ { "database": "UniProtKB", "id": "A2AJL3", "url": "https://www.uniprot.org/uniprot/A2AJL3" } ], "pmid": "" }, { "name": "carbohydrate phosphorylation", "id": "GO:0046835", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046835", "evidence": [ { "database": "UniProtKB", "id": "A2AJL3", "url": "https://www.uniprot.org/uniprot/A2AJL3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "kinase activity", "id": "GO:0016301", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016301", "evidence": [ { "database": "UniProtKB", "id": "A2AJL3", "url": "https://www.uniprot.org/uniprot/A2AJL3" } ], "pmid": "" }, { "name": "phosphotransferase activity, alcohol group as acceptor", "id": "GO:0016773", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016773", "evidence": [ { "database": "UniProtKB", "id": "A2AJL3", "url": "https://www.uniprot.org/uniprot/A2AJL3" } ], "pmid": "" }, { "name": "D-ribulokinase activity", "id": "GO:0019150", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019150", "evidence": [ { "database": "UniProtKB", "id": "A2AJL3", "url": "https://www.uniprot.org/uniprot/A2AJL3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A2AJL3", "url": "https://www.uniprot.org/uniprot/A2AJL3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 128, "end_pos": 130, "annotation": "n_glycosylation_sequon" }, { "start_pos": 220, "end_pos": 222, "annotation": "n_glycosylation_sequon" }, { "start_pos": 396, "end_pos": 398, "annotation": "n_glycosylation_sequon" }, { "start_pos": 550, "end_pos": 552, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "17601", "name": "", "equation": "ATP + D-ribulose = ADP + D-ribulose 5-phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A2AJL3-1" ], "evidence": [ { "id": "17601", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/17601" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A2AJL3", "gene_name": "Fggy", "activity": [ { "ec_number": "2.7.1.47", "activity": "ATP + D-ribulose = ADP + D-ribulose 5-phosphate + H(+).", "evidence": [ { "id": "A2AJL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2AJL3" } ] } ] } ], "biomarkers": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.7.1.47", "ec_name": "ATP + D-ribulose = ADP + D-ribulose 5-phosphate + H(+).", "evidence": [ { "id": "2.7.1.47", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.47" }, { "id": "2.7.1.47", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.7.1.47" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 128, "end_pos": 130 }, { "start_pos": 220, "end_pos": 222 }, { "start_pos": 396, "end_pos": 398 }, { "start_pos": 550, "end_pos": 552 } ] }, 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