{ "uniprot_canonical_ac": "A2AG06-1", "uniprot_ac": "A2AG06", "uniprot_id": "MEIOC_MOUSE", "mass": { "chemical_mass": 108830.0, "monoisotopic_mass": 108830.0 }, "refseq": { "ac": "NP_001121048", "name": "meiosis-specific coiled-coil domain-containing protein MEIOC", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001121048" }, "gene_names": [ { "name": "Meioc", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A2AG06", "id": "A2AG06" }, { "name": "Gm1564; Gm663", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001121048", "id": "NP_001121048" }, { "name": "Gm1564", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A2AG06", "id": "A2AG06" }, { "name": "Meioc", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001121048", "id": "NP_001121048" } ], "protein_names": [ { "name": "Meiosis-specific coiled-coil domain-containing protein MEIOC", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprotkb/A2AG06/entry#names_and_taxonomy", "id": "A2AG06" }, { "name": "Meiosis-specific with coiled-coil domain protein", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A2AG06/entry#names_and_taxonomy", "id": "A2AG06" }, { "name": "meiosis-specific coiled-coil domain-containing protein MEIOC", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001121048", "id": "NP_001121048" }, { "name": "meiosis-specific with coiled-coil domain protein", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001121048", "id": "NP_001121048" } ], "function": [ { "annotation": "Is required for meiosis completion in both male and female germ cells. Confers stability to numerous meiotic mRNAs in gonads allowing proper initiation and progression into meiosis prophase I. The function may involve YTHDC2 and is independent of induction by retinoic acid (RA). Maintains an extended meiotic prophase I by properly promoting the transition from a mitotic to a meiotic cell cycle program by binding transcripts through its interaction with YTHDC2 that regulate the mitotic cell cycle (PubMed:28380054).", "evidence": [ { "database": "UniProtKB", "id": "A2AG06", "url": "https://www.uniprot.org/uniprot/A2AG06#function" }, { "database": "PubMed", "id": "28380054", "url": "https://glygen.org/publication/PubMed/28380054" }, { "database": "PubMed", "id": "26742488", "url": "https://glygen.org/publication/PubMed/26742488" } ] }, { "annotation": "Meioc invalidation in mice induces early and pleiotropic meiotic defects in males and females. MEIOC prevents meiotic transcript degradation and interacts with an RNA helicase that binds numerous meiotic mRNAs. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001121048", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001121048" }, { "database": "PubMed", "id": "26742488", "url": "https://glygen.org/publication/PubMed/26742488" } ] }, { "annotation": "We conclude that when the meiotic chromosomal program is initiated, Meioc is simultaneously induced so as to extend meiotic prophase. Specifically, MEIOC, together with YTHDC2, promotes a meiotic (as opposed to mitotic) cell cycle program via post-transcriptional control of their target transcripts. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001121048", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001121048" }, { "database": "PubMed", "id": "28380054", "url": "https://glygen.org/publication/PubMed/28380054" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "A2AG06", "url": "https://www.uniprot.org/uniprot/A2AG06" } ], "common_name": "Mouse", "glygen_name": "Mouse", "reference_species": "Mus musculus [10090]" } ], "gene": [ { "name": "Meioc", "url": "https://www.uniprot.org/uniprot/A2AG06", "locus": { "chromosome": "11", "start_pos": 102573063, "end_pos": 102554542, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000051455", "url": "https://www.ensembl.org/id/ENSMUSG00000051455" } ] } } ], "crossref": [ { "id": "ENSMUSG00000051455", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000051455", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "268491", "url": "https://www.ncbi.nlm.nih.gov/gene/268491", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "A2AG06", "url": "https://www.ebi.ac.uk/intact/interactors/id:A2AG06*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR027963", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027963", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "mmu:268491", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:268491", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "2686410", "url": "http://www.informatics.jax.org/marker/MGI:2686410", "database": "MGI", "categories": [ "Organism-specific" ] }, { "id": "DFNYNGA", "url": "https://omabrowser.org/oma/group/DFNYNGA/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "2907561at2759", "url": "http://www.orthodb.org/?query=2907561at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR33861", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR33861", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR33861:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR33861:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15189", "url": "http://pfam.xfam.org/family/PF15189", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_A2AG06", "url": "http://purl.obolibrary.org/obo/PR_A2AG06", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_001121048", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001121048", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A0R3P9D4", "url": "https://www.uniprot.org/uniprot/A0A0R3P9D4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0R3P9D4-1", "url": "https://www.uniprot.org/uniprot/A0A0R3P9D4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A2AG06", "url": "https://www.uniprot.org/uniprot/A2AG06", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A2AG06-1", "url": "https://www.uniprot.org/uniprot/A2AG06-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A2AG06-2", "url": "https://www.uniprot.org/uniprot/A2AG06-2", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEVSGGDTCRPRHPQGLREGPEPKVAAAAAAFRGSANRCWNLSVDTSNRLSDVFNSMMLTGSAPFYDCYKSQNEDNVDLRQTCTPLSSSTEYASSIDSSLFYAPWSTYGDDIKQPPSSQISVKNRIQTERNDYGSETDLYGLVSNILEEQDKSQPYFAEGTCSSNLKSVWPMNTSRFVDHHDLLTEPKRPVDTSISQQAFYSGESVSAVEKQYLHNSSLTPQQKIDELYHGYTGLDLEEQWLYLSRSDHSNCYNSQANDTVKATFQEYPFVKNCFTPQTGLSDIMKESGIDTYAYGREKICTKGLETPLQHKRAEIFLSQFNRYNENADYCRYPEYAHPNKAKLNKCSNFSVQDGKKLANGTPETPTVEADAYTKLFQVKPANQKKMEETIPDQQNFAFPKTTPHLTEKQFAKEAAFTADFGLKSEYGLKPHTACPTNNDFANVSEKQQFAKPDPLNSEYFKSVNLFSNSATSSGGISLNRPTWMNVQTKNNLPIPYRNQGNLMKLNSHLSAASKGSNHSSDFPQLSSTNLTSNSNLFQKYCQENPSAFSSFDFSYNGAERIQSVNHMEGLTKTGEDNLFESVTEKKIKQPNGFCDSYSASQYGIIENVNKHNFQAKPQSGHYDPEDIPKHFDGLPQNTYQDLLESQGHFNSHRQGSGDNNINSRVNRTQASCFSNNYMMGDLRHNQGFQQLGSNGFPLRSTHPFGHSVVPLLDSYDLFSYDDLSHLYPYFNDMMYGDNSFSGFVPTFGFQRPIKTRSGPASELHIRLEECYEQWRALEKERKKTELALAKNYPGKKVSSTNNTPIPRLTSNPSRVDRLIVDELREQARVVTLLGKMERLRSSPLHANISTALDRHLESIHIVQSRRKDEIVNASNRQRQGVPRCQDDRDVFALATAIKEMCVATRKARTTLWCALQMTLPKTASTAGQADMEKAFQDLVNCEEKVHESINSSNPMNQRGETSKH", "length": 965, "header": "sp|A2AG06-1|MEIOC_MOUSE Isoform 1 of Meiosis-specific coiled-coil domain-containing protein MEIOC OS=Mus musculus OX=10090 GN=Meioc PE=1 SV=1 CANONICAL=A2AG06-1" }, "isoforms": [ { "isoform_ac": "A0A0R3P9D4-1", "url": "https://www.uniprot.org/uniprotkb/A2AG06/entry#A0A0R3P9D4-1", "sequence": { "sequence": "MMLTGSAPFYDCYKSQNEDNVDLRQTCTPLSSSTEYASSIDSSLFYAPWSTYGDDIKQPPSSQISVKNRIQTERNDYGSETDLYGLVSNILEEQDKSQPYFAEGTCSSNLKSVWPMNTSRFVDHHDLLTEPKRPVDTSISQQAFYSGESVSAVEKQYLHNSSLTPQQKIDELYHGYTGLDLEEQWLYLSRSDHSNCYNSQANDTVKATFQEYPFVKNCFTPQTGLSDIMKESGIDTYAYGREKICTKGLETPLQHKRAEIFLSQFNRYNENADYCRYPEYAHPNKAKLNKCSNFSVQDGKKLANGTPETPTVEADAYTKLFQVKPANQKKMEETIPDQQNFAFPKTTPHLTEKQFAKEAAFTADFGLKSEYGLKPHTACPTNNDFANVSEKQQFAKPDPLNSEYFKSVNLFSNSATSSGGISLNRPTWMNVQTKNNLPIPYRNQGNLMKLNSHLSAASKGSNHSSDFPQLSSTNLTSNSNLFQKYCQENPSAFSSFDFSYNGAERIQSVNHMEGLTKTGEDNLFESV", "length": 527, "header": "tr|A0A0R3P9D4-1|MEIOC_MOUSE Computationally mapped isoform of Meiosis-specific coiled-coil domain-containing protein MEIOC OS=Mus musculus OX=10090 GN=Meioc PE=1 SV=1 CANONICAL=A2AG06-1" }, "locus": { "chromosome": "11", "start_pos": 102566134, "end_pos": 102557264, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000156590.8", "url": "https://www.ensembl.org/id/ENSMUST00000156590.8" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000116246.2", "url": "https://www.ensembl.org/id/ENSMUSP00000116246.2" } ] } }, { "isoform_ac": "A2AG06-1", "url": "https://www.uniprot.org/uniprotkb/A2AG06/entry#A2AG06-1", "sequence": { "sequence": "MEVSGGDTCRPRHPQGLREGPEPKVAAAAAAFRGSANRCWNLSVDTSNRLSDVFNSMMLTGSAPFYDCYKSQNEDNVDLRQTCTPLSSSTEYASSIDSSLFYAPWSTYGDDIKQPPSSQISVKNRIQTERNDYGSETDLYGLVSNILEEQDKSQPYFAEGTCSSNLKSVWPMNTSRFVDHHDLLTEPKRPVDTSISQQAFYSGESVSAVEKQYLHNSSLTPQQKIDELYHGYTGLDLEEQWLYLSRSDHSNCYNSQANDTVKATFQEYPFVKNCFTPQTGLSDIMKESGIDTYAYGREKICTKGLETPLQHKRAEIFLSQFNRYNENADYCRYPEYAHPNKAKLNKCSNFSVQDGKKLANGTPETPTVEADAYTKLFQVKPANQKKMEETIPDQQNFAFPKTTPHLTEKQFAKEAAFTADFGLKSEYGLKPHTACPTNNDFANVSEKQQFAKPDPLNSEYFKSVNLFSNSATSSGGISLNRPTWMNVQTKNNLPIPYRNQGNLMKLNSHLSAASKGSNHSSDFPQLSSTNLTSNSNLFQKYCQENPSAFSSFDFSYNGAERIQSVNHMEGLTKTGEDNLFESVTEKKIKQPNGFCDSYSASQYGIIENVNKHNFQAKPQSGHYDPEDIPKHFDGLPQNTYQDLLESQGHFNSHRQGSGDNNINSRVNRTQASCFSNNYMMGDLRHNQGFQQLGSNGFPLRSTHPFGHSVVPLLDSYDLFSYDDLSHLYPYFNDMMYGDNSFSGFVPTFGFQRPIKTRSGPASELHIRLEECYEQWRALEKERKKTELALAKNYPGKKVSSTNNTPIPRLTSNPSRVDRLIVDELREQARVVTLLGKMERLRSSPLHANISTALDRHLESIHIVQSRRKDEIVNASNRQRQGVPRCQDDRDVFALATAIKEMCVATRKARTTLWCALQMTLPKTASTAGQADMEKAFQDLVNCEEKVHESINSSNPMNQRGETSKH", "length": 965, "header": "sp|A2AG06-1|MEIOC_MOUSE Isoform 1 of Meiosis-specific coiled-coil domain-containing protein MEIOC OS=Mus musculus OX=10090 GN=Meioc PE=1 SV=1 CANONICAL=A2AG06-1" }, "locus": { "chromosome": "11", "start_pos": 102571562, "end_pos": 102556591, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000100378.4", "url": "https://www.ensembl.org/id/ENSMUST00000100378.4" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000097947.4", "url": "https://www.ensembl.org/id/ENSMUSP00000097947.4" } ] } }, { "isoform_ac": "A2AG06-2", "url": "https://www.uniprot.org/uniprotkb/A2AG06/entry#A2AG06-2", "sequence": { "sequence": "MMLTGSAPFYDCYKSQNEDNVDLRQTCTPLSSSTEYASSIDSSLFYAPWSTYGDDIKQPPSSQISVKNRIQTERNDYGSETDLYGLVSNILEEQDKSQPYFAEGTCSSNLKSVWPMNTSRFVDHHDLLTEPKRPVDTSISQQAFYSGESVSAVEKQYLHNSSLTPQQKIDELYHGYTGLDLEEQWLYLSRSDHSNCYNSQANDTVKATFQEYPFVKNCFTPQTGLSDIMKESGIDTYAYGREKICTKGLETPLQHKRAEIFLSQFNRYNENADYCRYPEYAHPNKAKLNKCSNFSVQDGKKLANGTPETPTVEADAYTKLFQVKPANQKKMEETIPDQQNFAFPKTTPHLTEKQFAKEAAFTADFGLKSEYGLKPHTACPTNNDFANVSEKQQFAKPDPLNSEYFKSVNLFSNSATSSGGISLNRPTWMNVQTKNNLPIPYRNQGNLMKLNSHLSAASKGSNHSSDFPQLSSTNLTSNSNLFQKYCQENPSAFSSFDFSYNGAERIQSVNHMEGLTKTGEDNLFESVTEKKIKQPNGFCDSYSASQYGIIENVNKHNFQAKPQSGHYDPEDIPKHFDGLPQNTYQDLLESQGHFNSHRQGSGDNNINSRVNRTQASCFSNNYMMGDLRHNQGFQQLGSNGFPLRSTHPFGHSVVPLLDSYDLFSYDDLSHLYPYFNDMMYGDNSFSGFVPTFGFQRPIKTRSGPASELHIRLEECYEQWRALEKERKKTELALAKNYPGKKVSSTNNTPIPRLTSNPSRVDRLIVDELREQARVVTLLGKMERLRSSPLHANISTALDRHLESIHIVQSRRKDEIVNASNRQRQGVPRCQDDRDVFALATAIKEMCVATRKARTTLWCALQMTLPKTASTAGQADMEKAFQDLVNCEEKVHESINSSNPMNQRGETSKH", "length": 909, "header": "sp|A2AG06-2|MEIOC_MOUSE Isoform 2 of Meiosis-specific coiled-coil domain-containing protein MEIOC OS=Mus musculus OX=10090 GN=Meioc PE=1 SV=1 CANONICAL=A2AG06-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 800, "end_pos": 800, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "A2AG06", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2AG06" } ], "site_lbl": "Ser800" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Implementation of meiosis prophase I programme requires a conserved retinoid-independent stabilizer of meiotic transcripts.", "journal": "Nature communications", "date": "2016", "authors": "Abby E, Tourpin S, Ribeiro J, Daniel K, Messiaen S, Moison D, Guerquin J, Gaillard JC, Armengaud J, Langa F, Toth A, Martini E, Livera G", "evidence": [ { "database": "UniProtKB", "id": "A2AG06", "url": "https://www.uniprot.org/uniprot/A2AG06" }, { "database": "RefSeq", "id": "NP_001121048", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001121048" } ], "reference": [ { "type": "PubMed", "id": "26742488", "url": "https://glygen.org/publication/PubMed/26742488" } ] }, { "title": "Meioc maintains an extended meiotic prophase I in mice.", "journal": "PLoS genetics", "date": "2017", "authors": "Soh YQS, Mikedis MM, Kojima M, Godfrey AK, de Rooij DG, Page DC", "evidence": [ { "database": "UniProtKB", "id": "A2AG06", "url": "https://www.uniprot.org/uniprot/A2AG06" }, { "database": "RefSeq", "id": "NP_001121048", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001121048" } ], "reference": [ { "type": "PubMed", "id": "28380054", "url": "https://glygen.org/publication/PubMed/28380054" } ] }, { "title": "Regulation of m6A transcripts by the 3'-5' RNA helicase YTHDC2 is essential for a successful meiotic program in the mammalian germline.", "journal": "Mol. Cell", "date": "2017", "authors": "Wojtas MN, Pandey RR, Mendel M, Homolka D, Sachidanandam R, Pillai RS", "evidence": [ { "database": "UniProtKB", "id": "A2AG06", "url": "https://www.uniprot.org/uniprot/A2AG06" } ], "reference": [ { "type": "PubMed", "id": "29033321", "url": "https://glygen.org/publication/PubMed/29033321" } ] }, { "title": "RNA binding protein RBM46 regulates mitotic-to-meiotic transition in spermatogenesis.", "journal": "Sci. Adv.", "date": "2022", "authors": "Qian B, Li Y, Yan R, Han S, Bu Z, Gong J, Zheng B, Yuan Z, Ren S, He Q, Zhang J, Xu C, Wang R, Sun Z, Lin M, Zhou J, Ye L", "evidence": [ { "database": "UniProtKB", "id": "A2AG06", "url": "https://www.uniprot.org/uniprot/A2AG06" } ], "reference": [ { "type": "PubMed", "id": "36001654", "url": "https://glygen.org/publication/PubMed/36001654" } ] } ], "pathway": [ { "id": "mmu:268491", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:268491", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A2RUB1-4", "protein_name": "Meiosis-specific coiled-coil domain-containing protein MEIOC", "gene_name": "MEIOC", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEVRRGDTCPRPHPSGLREEGLEPKVAFPGGANRCWNLGADAGSRLTDVFGSVMLTGSASFYDCYTSQSEDNVDLRQTYTPFSSTEYSSSVDSSLFCAPWSTYGDDIKQPSNSQISIKNRIQTERNDYGSETDLYGLVSNILEEQDKSQPYFAEGTCSSNLKSVWPMNTSRFADHHDLLTETKRPIDTVISQQAFYSDESVSAMEKQYLRNSNLTPQQKIDELHHGFTGLDLEEQWMYPSRSDHSNCHNIQTNDTAKTTFQEYPLIKNCFTPQTGLSDIMKESGVDIYHYGRDRICTKGLEAPLQQKRAEMFLSQFNRYNENVDYCRYPEYVHPNKAKLNKCSNFSVQDSKKLANGTPETPTVEADTYTKLFQVKPANQKKMEETIPDQQNFTFPKTTPHLTEKQFAKEAVFTADFGLTSEYGLKPHTACPANDFANVTEKQQFAKPDPPHSEYFKSVNLLSNSATSSGGINLNRPTWMNVQTKNNTPIPYRNQGNLMKLNSHLSAASKGSNHSSDFPQLSSTNLTPNSNLFQKYCQENPSAFSSFDFSYSGAERIQSVNHIEGLTKPGEENLFKLVTDKKIKQPNGFCDNYSAQKYGIIENVNKHNFQAKPQSGHYDPEEGPKHLDGLSQNTYQDLLESQGHSNSHRTRGGDNSRVNRTQVSCFSNNYMMGDLRHNQCFQQLGSNGFPLRSTHPFGHSVVPLLDSYDLLSYDDLSHLYPYFNMMYGDNSFSGLMPTFGFQRPIKTRSGPASELHIRLEECCEQWRALEKERKKTELALAKNYPGKKVSSTNNTPVPRLTSNPSRVDRLIVDELRELARVVTLLGKMERLRSSLLHASISTALDRHLESIHIVQSRRKDEIVNASNRQRQGVPRCQDDRDVFALASAIKEMCVATRKTRTALWCALQMTLPKTASTADVVKPLQDTVNCEDKVHESINSSNPMNQRGETNKH", "length": 952 }, "evidence": [ { "id": "46368224", "url": "http://www.informatics.jax.org/homology/46368224", "database": "MGI" }, { "id": "A2AG06", "url": "https://omabrowser.org/oma/group/A2AG06/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "D4A1P7-1", "protein_name": "Meiosis specific with coiled-coil domain", "gene_name": "Meioc", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEVSGGDTCRPRHPQGLREGPEPKVAFRGSANRCWNLSVDTSSRLSDVFNSMMLTGSTSFYDCYKSQNEDNVDLRQTCTPLSSSAEYASSIDSSLFYAPWSTYGDDIKQPSSSQISVKNRIQTERNDYGSETDLYGLVSNILEEQDKSQPYFAEGTCSSNLKSVWPMNTSRFVDHHDLLTENKRPIDTSISQQAFYSGESVSAVEKQYLHNSTLTPQQKIDELYHGYTGLDLEEQWLYLSRSDHSNCYNIQTNDTVKATFQEYPFIKNCFTPQTGLSDIMKESGIDTYAYGREKICAKGLETPLQHKRAEIFLSQFNRFNENADYCRYPEYAHPNKTKLNKCSNFSVQDGKKLANGTPETPTVEADAYTKLFQVKPANQKKMEETIPDQQNFAFPKTTPHLTEKQFAKEAAFTADFGLKSEYGLKPHTACPANNDFANVTEKQQFAKPDTLNSEYFKSVNLFSNSATSSGGISLNRPTWMNVQTKNNLPIPYRNQGNLMKLNSHLSAASKGSNHSSDFPQLSSTNLTSNSNLFQKYCQENPSAFSSFDFSYNGAERIQSVNHMEGLTKTGEDNLFESVTEKKIKQPNGFCDGCSASQYGVIENVNKHNFQAKPQSGHYDPEDIPKHFDGLPQNTYQDLLESQGHFNSHRQGSGDNNINSRVNRTQASCFSNNYMMGDLRHNQGFQQLGSNGFPLRSTHPFGHSVVPLLDSYDLFSYDDLSHLYPYFNDMMYGDNSFSGFVPTFGFQRPIKTRSGPASELHIRLEECYEQWRALEKERKKTELALAKNYPGKKVSSTNNTPIPRLTSNPSRVDRLIVDELREQARVVTLLGKMERLRSSPLHANISTALDRHLESIHIVQSRRKDEIVNASNRQRQGVPRCQDDRDVFALATAIKEMCVATRKARTTLWCALQMTLPKTASTAGQADMEKAFQDLVNCEDKVHESINSSNPMNQRGETSKH", "length": 960 }, "evidence": [ { "id": "46368224", "url": "http://www.informatics.jax.org/homology/46368224", "database": "MGI" }, { "id": "A2AG06", "url": "https://omabrowser.org/oma/group/A2AG06/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1RQZ6-1", "protein_name": "Meiosis specific with coiled-coil domain", "gene_name": "MEIOC", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": 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"id": "A2AG06", "url": "https://omabrowser.org/oma/group/A2AG06/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 12, "go_terms": [ { "name": "metaphase chromosome alignment", "id": "GO:0051310", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051310", "evidence": [ { "database": "UniProtKB", "id": "A2AG06", "url": "https://www.uniprot.org/uniprot/A2AG06" } ], "pmid": "" }, { "name": "female meiosis I", "id": "GO:0007144", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007144", "evidence": [ { "database": "UniProtKB", "id": "A2AG06", "url": "https://www.uniprot.org/uniprot/A2AG06" } ], "pmid": "" }, { "name": "spermatogenesis", "id": "GO:0007283", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007283", "evidence": [ { "database": "UniProtKB", "id": "A2AG06", "url": "https://www.uniprot.org/uniprot/A2AG06" } ], "pmid": "" }, { "name": "mRNA stabilization", "id": "GO:0048255", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048255", "evidence": [ { "database": "UniProtKB", "id": "A2AG06", "url": "https://www.uniprot.org/uniprot/A2AG06" } ], "pmid": "" }, { "name": "spermatid development", "id": "GO:0007286", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007286", "evidence": [ { "database": "UniProtKB", "id": "A2AG06", "url": "https://www.uniprot.org/uniprot/A2AG06" } ], "pmid": "" }, { "name": "double-strand break repair", "id": "GO:0006302", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006302", "evidence": [ { "database": "UniProtKB", "id": "A2AG06", "url": "https://www.uniprot.org/uniprot/A2AG06" } ], "pmid": "" }, { "name": "synaptonemal complex assembly", "id": "GO:0007130", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007130", "evidence": [ { "database": "UniProtKB", "id": "A2AG06", "url": "https://www.uniprot.org/uniprot/A2AG06" } ], "pmid": "" }, { "name": "oocyte development", "id": "GO:0048599", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048599", "evidence": [ { "database": "UniProtKB", "id": "A2AG06", "url": "https://www.uniprot.org/uniprot/A2AG06" } ], "pmid": "" }, { "name": "male meiosis I", "id": "GO:0007141", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007141", "evidence": [ { "database": "UniProtKB", "id": "A2AG06", "url": "https://www.uniprot.org/uniprot/A2AG06" } ], "pmid": "" }, { "name": "chromosome organization involved in meiotic cell cycle", "id": "GO:0070192", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070192", "evidence": [ { "database": "UniProtKB", "id": "A2AG06", "url": "https://www.uniprot.org/uniprot/A2AG06" } ], "pmid": "" }, { "name": "germline cell cycle switching, mitotic to meiotic cell cycle", "id": "GO:0051729", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051729", "evidence": [ { "database": "UniProtKB", "id": "A2AG06", "url": "https://www.uniprot.org/uniprot/A2AG06" } ], "pmid": "" }, { "name": "meiotic cell cycle", "id": "GO:0051321", "url": 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[], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 800 ], "sequon_annotation_sites": [ { "start_pos": 173, "end_pos": 175 }, { "start_pos": 216, "end_pos": 218 }, { "start_pos": 258, "end_pos": 260 }, { "start_pos": 349, "end_pos": 351 }, { "start_pos": 360, "end_pos": 362 }, { "start_pos": 41, "end_pos": 43 }, { "start_pos": 443, "end_pos": 445 }, { "start_pos": 518, "end_pos": 520 }, { "start_pos": 530, "end_pos": 532 }, { "start_pos": 667, "end_pos": 669 }, { "start_pos": 802, "end_pos": 804 }, { "start_pos": 848, "end_pos": 850 }, { "start_pos": 873, "end_pos": 875 }, { "start_pos": 951, "end_pos": 953 } ] }, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { 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