{ "uniprot_canonical_ac": "A2A9R3-1", "uniprot_ac": "A2A9R3", "uniprot_id": "MAGB4_MOUSE", "mass": { "chemical_mass": 60922.0, "monoisotopic_mass": 60922.0 }, "refseq": { "ac": "NP_001028664", "name": "melanoma-associated antigen B4", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028664" }, "gene_names": [ { "name": "Mageb4", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A2A9R3", "id": "A2A9R3" }, { "name": "Mage-b4; mMage-b4", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028664", "id": "NP_001028664" }, { "name": "Mageb4", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028664", "id": "NP_001028664" } ], "protein_names": [ { "name": "Melanoma-associated antigen B4", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprotkb/A2A9R3/entry#names_and_taxonomy", "id": "A2A9R3" }, { "name": "melanoma antigen, family B, 4", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028664", "id": "NP_001028664" }, { "name": "melanoma-associated antigen B4", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028664", "id": "NP_001028664" } ], "function": [ { "annotation": "MAGE-B4, a binding partner of PRAMEF12, is dispensable for spermatogenesis and male fertility in mice.", "evidence": [ { "database": "RefSeq", "id": "NP_001028664", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028664" }, { "database": "PubMed", "id": "37451217", "url": "https://glygen.org/publication/PubMed/37451217" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "A2A9R3", "url": "https://www.uniprot.org/uniprot/A2A9R3" } ], "common_name": "Mouse", "glygen_name": "Mouse", "reference_species": "Mus musculus [10090]" } ], "gene": [ { "name": "Mageb4", "url": "https://www.uniprot.org/uniprot/A2A9R3", "locus": { "chromosome": "X", "start_pos": 85293860, "end_pos": 85348699, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000035427", "url": "https://www.ensembl.org/id/ENSMUSG00000035427" } ] } } ], "crossref": [ { "id": "ENSMUSG00000035427", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000035427", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "434903", "url": "https://www.ncbi.nlm.nih.gov/gene/434903", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002190", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002190", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR021072", "url": "https://www.ebi.ac.uk/interpro/entry/IPR021072", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037445", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037445", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041898", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041898", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041899", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041899", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "mmu:434903", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:434903", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "2148568", "url": "http://www.informatics.jax.org/marker/MGI:2148568", "database": "MGI", "categories": [ "Organism-specific" ] }, { "id": "NGNCARE", "url": "https://omabrowser.org/oma/group/NGNCARE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "3128316at2759", "url": "http://www.orthodb.org/?query=3128316at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11736", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11736", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11736:SF22", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11736:SF22", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01454", "url": "http://pfam.xfam.org/family/PF01454", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF12440", "url": "http://pfam.xfam.org/family/PF12440", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_A2A9R3", "url": "http://purl.obolibrary.org/obo/PR_A2A9R3", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_001028664", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028664", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A2A9R3", "url": "https://www.uniprot.org/uniprot/A2A9R3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A2A9R3-1", "url": "https://www.uniprot.org/uniprot/A2A9R3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPRGQKSKARAREKRRLVQDEAQELQDAQAKAGEKGKSPSCSNQDSGDAVASTSTAGFPQKSKSQGEAPTTTARKGGACRRSRKSTRGPREESTSCTRVPRFSENPQNDLLTRKTGMLMQYLLCKYKMKQPASKGEMLKVINRRFKEQLPEILKKASERIQLVFGLEVKEIKPNGGYYTLVSKLDPSVGNALTTSLPFPQNGLLMPLLGVIFLNGNRASEAEIWEFLNVLGIYDGKVHIIFGEPRKLITRDLVKEKYLVYQKEANSDPPSFEFLWGPRAYAETTKMKILEFLAEVNETVPQAFPTHYEEALRDQEERAQAEAVGSPGTSAKDKAEAKVTLVDSSCKYQAESKVTLVDSSCKDQAESKVTLVDPSCKDNAKSKVTLGSSRKYKAKSKVPLVDSSCKDQAESKVTLVDSCKDQAESKVTLVDSSCKDQAESKVTLVDSSCKDQAESKVTLVDPSCKDKAKSKVTLGSSHKYKAKSKVTLVDSSCKDQAESKVTLVDSSCKDQAESKVTLVDPSCKDNAKSKVTLGSSRKYKAKSKVPLVDSSGKDKAV", "length": 556, "header": "sp|A2A9R3-1|MAGB4_MOUSE Isoform 1 of Melanoma-associated antigen B4 OS=Mus musculus OX=10090 GN=Mageb4 PE=1 SV=1 CANONICAL=A2A9R3-1" }, "isoforms": [ { "isoform_ac": "A2A9R3-1", "url": "https://www.uniprot.org/uniprotkb/A2A9R3/entry#A2A9R3-1", "sequence": { "sequence": "MPRGQKSKARAREKRRLVQDEAQELQDAQAKAGEKGKSPSCSNQDSGDAVASTSTAGFPQKSKSQGEAPTTTARKGGACRRSRKSTRGPREESTSCTRVPRFSENPQNDLLTRKTGMLMQYLLCKYKMKQPASKGEMLKVINRRFKEQLPEILKKASERIQLVFGLEVKEIKPNGGYYTLVSKLDPSVGNALTTSLPFPQNGLLMPLLGVIFLNGNRASEAEIWEFLNVLGIYDGKVHIIFGEPRKLITRDLVKEKYLVYQKEANSDPPSFEFLWGPRAYAETTKMKILEFLAEVNETVPQAFPTHYEEALRDQEERAQAEAVGSPGTSAKDKAEAKVTLVDSSCKYQAESKVTLVDSSCKDQAESKVTLVDPSCKDNAKSKVTLGSSRKYKAKSKVPLVDSSCKDQAESKVTLVDSCKDQAESKVTLVDSSCKDQAESKVTLVDSSCKDQAESKVTLVDPSCKDKAKSKVTLGSSHKYKAKSKVTLVDSSCKDQAESKVTLVDSSCKDQAESKVTLVDPSCKDNAKSKVTLGSSRKYKAKSKVPLVDSSGKDKAV", "length": 556, "header": "sp|A2A9R3-1|MAGB4_MOUSE Isoform 1 of Melanoma-associated antigen B4 OS=Mus musculus OX=10090 GN=Mageb4 PE=1 SV=1 CANONICAL=A2A9R3-1" }, "locus": { "chromosome": "X", "start_pos": 85296027, "end_pos": 85294360, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000096378.3", "url": "https://www.ensembl.org/id/ENSMUST00000096378.3" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000094107.3", "url": "https://www.ensembl.org/id/ENSMUSP00000094107.3" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 325, "end_pos": 325, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A2A9R3", "url": "https://www.uniprot.org/uniprot/A2A9R3" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" }, { "database": "iPTMnet", "id": "A2A9R3", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2A9R3" } ], "site_lbl": "Ser325" }, { "start_pos": 93, "end_pos": 93, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "A2A9R3", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2A9R3" } ], "site_lbl": "Ser93" }, { "start_pos": 94, "end_pos": 94, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "A2A9R3", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2A9R3" } ], "site_lbl": "Thr94" }, { "start_pos": 97, "end_pos": 97, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "A2A9R3", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2A9R3" } ], "site_lbl": "Thr97" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Mage-b4, a novel melanoma antigen (MAGE) gene specifically expressed during germ cell differentiation.", "journal": "Cancer Res.", "date": "2000", "authors": "Osterlund C, Tohonen V, Forslund KO, Nordqvist K", "evidence": [ { "database": "UniProtKB", "id": "A2A9R3", "url": "https://www.uniprot.org/uniprot/A2A9R3" } ], "reference": [ { "type": "PubMed", "id": "10706124", "url": "https://glygen.org/publication/PubMed/10706124" } ] }, { "title": "A tissue-specific atlas of mouse protein phosphorylation and expression.", "journal": "Cell", "date": "2010", "authors": "Huttlin EL, Jedrychowski MP, Elias JE, Goswami T, Rad R, Beausoleil SA, Villen J, Haas W, Sowa ME, Gygi SP", "evidence": [ { "database": "UniProtKB", "id": "A2A9R3", "url": "https://www.uniprot.org/uniprot/A2A9R3" }, { "database": "iPTMnet", "id": "A2A9R3", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2A9R3" } ], "reference": [ { "type": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" } ] }, { "title": "MAGE-B4, a binding partner of PRAMEF12, is dispensable for spermatogenesis and male fertility in mice.", "journal": "Biochemical and biophysical research communications", "date": "2023-10-01", "authors": "Li Nana, Yu Junjie, Zhou Meiyang, Qiu Fanyi, Wang Xiao, Wang Zhengpin", "evidence": [ { "database": "RefSeq", "id": "NP_001028664", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028664" } ], "reference": [ { "type": "PubMed", "id": "37451217", "url": "https://glygen.org/publication/PubMed/37451217" } ] } ], "pathway": [ { "id": "mmu:434903", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:434903", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8I6AAL9-1", "protein_name": "MAGE family member B2", "gene_name": "Mageb2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPRGHKSKARAREKRRQVQDEAQGLKNAQAKAAEKGESSSCSDHDSGDAVASTSTAGFPQSKALTTSTAGFPQKSKSQGQAPTTTVRKVGPYRRSRKSTKGPREESTSCTRVPSFIENPQNDLLTRKTGILMQYLLCKYKMKQPANKGEMLKVINKRFKEQLPDILKKASERIQLVFGLEVKEIKPNGGYYTLVSKLDPNVGGTLTTSLPFPQNGLLMPLLGVIFLNGNRASEADIWEFLNILGIHDGKVHIIFGEPRKLITRDLVKEKYLVYQKEANSNPPSFEFLWGPRAYAETTKMKVLEFLAKVNETVPQAFPTHYQEALRDQEERAQAEAVGSPGTSAKDEAESKVRPVNSSCKDDAESKVRPVNSSCKDDAESKVRPVNSSCKDEAQSKVRPVNSSCKDEAQSKVRPVDSSHKGEAQSKVKLVDSSSKDKAKSKAKHVDASSKDKAKSKAKHVDASCKDKAKSK", "length": 470 }, "evidence": [ { "id": "A2A9R3", "url": "https://omabrowser.org/oma/group/A2A9R3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "O15479-1", "protein_name": "Melanoma-associated antigen B2", "gene_name": "MAGEB2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPRGQKSKLRAREKRRKARDETRGLNVPQVTEAEEEEAPCCSSSVSGGAASSSPAAGIPQEPQRAPTTAAAAAAGVSSTKSKKGAKSHQGEKNASSSQASTSTKSPSEDPLTRKSGSLVQFLLYKYKIKKSVTKGEMLKIVGKRFREHFPEILKKASEGLSVVFGLELNKVNPNGHTYTFIDKVDLTDEESLLSSWDFPRRKLLMPLLGVIFLNGNSATEEEIWEFLNMLGVYDGEEHSVFGEPWKLITKDLVQEKYLEYKQVPSSDPPRFQFLWGPRAYAETSKMKVLEFLAKVNGTTPCAFPTHYEEALKDEEKAGV", "length": 319 }, "evidence": [ { "id": "46361268", "url": "http://www.informatics.jax.org/homology/46361268", "database": "MGI" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "O15481-1", "protein_name": "Melanoma-associated antigen B4", "gene_name": "MAGEB4", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPRGQKSKLRAREKRQRTRGQTQDLKVGQPTAAEKEESPSSSSSVLRDTASSSLAFGIPQEPQREPPTTSAAAAMSCTGSDKGDESQDEENASSSQASTSTERSLKDSLTRKTKMLVQFLLYKYKMKEPTTKAEMLKIISKKYKEHFPEIFRKVSQRTELVFGLALKEVNPTTHSYILVSMLGPNDGNQSSAWTLPRNGLLMPLLSVIFLNGNCAREEEIWEFLNMLGIYDGKRHLIFGEPRKLITQDLVQEKYLEYQQVPNSDPPRYQFLWGPRAHAETSKMKVLEFLAKVNDTTPNNFPLLYEEALRDEEERAGARPRVAARRGTTAMTSAYSRATSSSSSQPM", "length": 346 }, "evidence": [ { "id": "46361268", "url": "http://www.informatics.jax.org/homology/46361268", "database": "MGI" }, { "id": "A2A9R3", "url": "https://omabrowser.org/oma/group/A2A9R3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P43366-1", "protein_name": "Melanoma-associated antigen B1", "gene_name": "MAGEB1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPRGQKSKLRAREKRRKAREETQGLKVAHATAAEKEECPSSSPVLGDTPTSSPAAGIPQKPQGAPPTTTAAAAVSCTESDEGAKCQGEENASFSQATTSTESSVKDPVAWEAGMLMHFILRKYKMREPIMKADMLKVVDEKYKDHFTEILNGASRRLELVFGLDLKEDNPSGHTYTLVSKLNLTNDGNLSNDWDFPRNGLLMPLLGVIFLKGNSATEEEIWKFMNVLGAYDGEEHLIYGEPRKFITQDLVQEKYLKYEQVPNSDPPRYQFLWGPRAYAETTKMKVLEFLAKMNGATPRDFPSHYEEALRDEEERAQVRSSVRARRRTTATTFRARSRAPFSRSSHPM", "length": 347 }, "evidence": [ { "id": "46361268", "url": "http://www.informatics.jax.org/homology/46361268", "database": "MGI" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "negative regulation of transcription by RNA polymerase II", "id": "GO:0000122", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000122", "evidence": [ { "database": "UniProtKB", "id": "A2A9R3", "url": "https://www.uniprot.org/uniprot/A2A9R3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A2A9R3", "url": "https://www.uniprot.org/uniprot/A2A9R3" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A2A9R3", "url": "https://www.uniprot.org/uniprot/A2A9R3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 296, "end_pos": 298, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 93, 94, 97, 325 ], "sequon_annotation_sites": [ { "start_pos": 296, "end_pos": 298 } ] }, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 4 }, { "field": "total_sites", "count": 4 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 3 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }