{ "uniprot_canonical_ac": "A2A884-1", "uniprot_ac": "A2A884", "uniprot_id": "ZEP3_MOUSE", "mass": { "chemical_mass": 253413.0, "monoisotopic_mass": 253413.0 }, "refseq": { "ac": "NP_034787", "name": "transcription factor HIVEP3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034787" }, "gene_names": [ { "name": "Hivep3", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A2A884", "id": "A2A884" }, { "name": "2900056N03Rik; A130075N07; E030045D18Rik; KBP-1; KBP1; Krc; Rc; Schnurri-3; Shn3; Zas3", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034787", "id": "NP_034787" }, { "name": "Hivep3", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034787", "id": "NP_034787" }, { "name": "KBP1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A2A884", "id": "A2A884" }, { "name": "Kiaa1555", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A2A884", "id": "A2A884" }, { "name": "Krc", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A2A884", "id": "A2A884" }, { "name": "Rc", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A2A884", "id": "A2A884" }, { "name": "Zas3", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A2A884", "id": "A2A884" }, { "name": "shn3", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A2A884", "id": "A2A884" } ], "protein_names": [ { "name": "Transcription factor HIVEP3", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprotkb/A2A884/entry#names_and_taxonomy", "id": "A2A884" }, { "name": "Human immunodeficiency virus type I enhancer-binding protein 3 homolog", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A2A884/entry#names_and_taxonomy", "id": "A2A884" }, { "name": "KB-binding and recognition component", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A2A884/entry#names_and_taxonomy", "id": "A2A884" }, { "name": "KBP-1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A2A884/entry#names_and_taxonomy", "id": "A2A884" }, { "name": "Kappa-B and V(D)J recombination signal sequences-binding protein", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A2A884/entry#names_and_taxonomy", "id": "A2A884" }, { "name": "Kappa-binding protein 1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A2A884/entry#names_and_taxonomy", "id": "A2A884" }, { "name": "Recombinant component", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A2A884/entry#names_and_taxonomy", "id": "A2A884" }, { "name": "Schnurri-3", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A2A884/entry#names_and_taxonomy", "id": "A2A884" }, { "name": "Zinc finger protein ZAS3", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A2A884/entry#names_and_taxonomy", "id": "A2A884" }, { "name": "recombinant component; kappa-binding protein 1; zinc finger protein ZAS3; KB-binding and regognition component; kappa-B and V(D)J recombination signal sequences-binding protein; human immunodeficiency virus type I enhancer-binding protein 3 homolog; kappa B and Rss recognition component; KB-binding and recognition component", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034787", "id": "NP_034787" }, { "name": "transcription factor HIVEP3", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034787", "id": "NP_034787" } ], "function": [ { "annotation": "KRC overexpression inhibits while antisense or dominant-negative KRC enhances NFkappaB-dependent transactivation and JNK phosphorylation and consequently, apoptosis and cytokine gene expression", "evidence": [ { "database": "RefSeq", "id": "NP_034787", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034787" }, { "database": "PubMed", "id": "11804591", "url": "https://glygen.org/publication/PubMed/11804591" } ] }, { "annotation": "Plays a role of transcription factor; binds to recognition signal sequences (Rss heptamer) for somatic recombination of immunoglobulin and T-cell receptor gene segments; Binds also to the kappa-B motif of gene such as S100A4, involved in cell progression and differentiation. Kappa-B motif is a gene regulatory element found in promoters and enhancers of genes involved in immunity, inflammation, and growth and that responds to viral antigens, mitogens, and cytokines. Involvement of HIVEP3 in cell growth is strengthened by the fact that its down-regulation promotes cell cycle progression with ultimate formation of multinucleated giant cells. Strongly inhibits TNF-alpha-induced NF-kappa-B activation; Interferes with nuclear factor NF-kappa-B by several mechanisms: as transcription factor, by competing for Kappa-B motif and by repressing transcription in the nucleus; through a non transcriptional process, by inhibiting nuclear translocation of RELA by association with TRAF2, an adapter molecule in the tumor necrosis factor signaling, which blocks the formation of IKK complex. Interaction with TRAF proteins inhibits both NF-Kappa-B-mediated and c-Jun N-terminal kinase/JNK-mediated responses that include apoptosis and pro-inflammatory cytokine gene expression. Positively regulates the expression of IL2 in T-cell. Essential regulator of adult bone formation.", "evidence": [ { "database": "UniProtKB", "id": "A2A884", "url": "https://www.uniprot.org/uniprot/A2A884#function" }, { "database": "PubMed", "id": "10625627", "url": "https://glygen.org/publication/PubMed/10625627" }, { "database": "PubMed", "id": "12193271", "url": "https://glygen.org/publication/PubMed/12193271" }, { "database": "PubMed", "id": "14707112", "url": "https://glygen.org/publication/PubMed/14707112" }, { "database": "PubMed", "id": "11035930", "url": "https://glygen.org/publication/PubMed/11035930" }, { "database": "PubMed", "id": "14530385", "url": "https://glygen.org/publication/PubMed/14530385" }, { "database": "PubMed", "id": "12001065", "url": "https://glygen.org/publication/PubMed/12001065" }, { "database": "PubMed", "id": "8812474", "url": "https://glygen.org/publication/PubMed/8812474" }, { "database": "PubMed", "id": "8255760", "url": "https://glygen.org/publication/PubMed/8255760" }, { "database": "PubMed", "id": "11804591", "url": "https://glygen.org/publication/PubMed/11804591" } ] }, { "annotation": "Schnurri-3 drives tumor growth and invasion in cancer cells expressing interleukin-13 receptor alpha 2. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_034787", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034787" }, { "database": "PubMed", "id": "37963919", "url": "https://glygen.org/publication/PubMed/37963919" } ] }, { "annotation": "Schnurri-3 inhibition suppresses bone and joint damage in models of rheumatoid arthritis.", "evidence": [ { "database": "RefSeq", "id": "NP_034787", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034787" }, { "database": "PubMed", "id": "37141171", "url": "https://glygen.org/publication/PubMed/37141171" } ] } ], "disease": [ { "disease_id": "DOID:0050787", "recommended_name": { "id": "DOID:0050787", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050787", "name": "juvenile polyposis syndrome", "description": "A gastrointestinal system disease that is characterized by predisposition to hamartomatous benign polyps in the gastrointestinal tract, specifically in the stomach, small intestine, colon, and rectum." }, "synonyms": [ { "id": "MONDO:0017380", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0017380", "name": "juvenile polyposis syndrome", "description": "Juvenile gastrointestinal polyposis (JIP) is a rare condition characterized by the presence of juvenile hamartomatous polyps in the gastrointestinal (GI) tract." }, { "id": "MONDO:0017380", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0017380", "name": "JIP", "description": "" }, { "id": "MONDO:0017380", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0017380", "name": "jPS", "description": "" }, { "id": "MONDO:0017380", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0017380", "name": "juvenile gastrointestinal polyposis", "description": "" }, { "id": "MONDO:0017380", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0017380", "name": "juvenile intestinal polyposis", "description": "" }, { "id": "MONDO:0017380", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0017380", "name": "juvenile multiple polyps syndrome", "description": "" }, { "id": "MONDO:0017380", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0017380", "name": "juvenile polyposis", "description": "" }, { "id": "MONDO:0017380", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0017380", "name": "juvenile polyposis syndrome", "description": "" }, { "id": "MONDO:0017380", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0017380", "name": "polyposis, juvenile intestinal", "description": "" }, { "id": "MONDO:0017380", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0017380", "name": "PJI", "description": "" }, { "id": "MONDO:0017380", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0017380", "name": "polyposis familial of entire gastrointestinal tract", "description": "" }, { "id": "MONDO:0017380", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0017380", "name": "polyposis juvenile intestinal", "description": "" }, { "id": "MIM:174900", "resource": "MIM", "url": "https://www.omim.org/entry/174900", "name": "Juvenile polyposis syndrome", "description": "Juvenile polyposis syndrome" } ], "evidence": [ { "id": "0050787", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0050787" } ] }, { "disease_id": "DOID:10652", "recommended_name": { "id": "DOID:10652", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10652", "name": "Alzheimer's disease", "description": "A tauopathy that is characterized by memory lapses, confusion, emotional instability and progressive loss of mental ability and results in progressive memory loss, impaired thinking, disorientation, and changes in personality and mood starting and leads in advanced cases to a profound decline in cognitive and physical functioning and is marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid." }, "synonyms": [ { "id": "DOID:10652", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10652", "name": "Alzheimer disease", "description": "" }, { "id": "DOID:10652", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10652", "name": "Alzheimers dementia", "description": "" } ], "evidence": [ { "id": "10652", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:10652" } ] } ], "snv": [ { "evidence": [ { "id": "rs3388706477", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs3388706477" } ], "glycoeffect": [ "n-glyco-sequon-gain", "o-glyco-site-loss" ], "start_pos": 533, "end_pos": 533, "sequence_org": "S", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (SHS->NHS).", "chr_id": "4", "chr_pos": "119953283", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "S533", "keywords": [ "ebi", "germline" ] } ], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "A2A884", "url": "https://www.uniprot.org/uniprot/A2A884" } ], "common_name": "Mouse", "glygen_name": "Mouse", "reference_species": "Mus musculus [10090]" } ], "gene": [ { "name": "Hivep3", "url": "https://www.uniprot.org/uniprot/A2A884", "locus": { "chromosome": "4", "start_pos": 119995242, "end_pos": 119590981, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000028634", "url": "https://www.ensembl.org/id/ENSMUSG00000028634" } ] } } ], "crossref": [ { "id": "ENSMUSG00000028634", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000028634", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "16656", "url": "https://www.ncbi.nlm.nih.gov/gene/16656", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "A2A884", "url": "https://www.ebi.ac.uk/intact/interactors/id:A2A884*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034729", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034729", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "mmu:16656", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:16656", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "106589", "url": "http://www.informatics.jax.org/marker/MGI:106589", "database": "MGI", "categories": [ "Organism-specific" ] }, { "id": "A2A884", "url": "https://oglcnac.org/atlas/detail/A2A884", "database": "O-GlcNAc Atlas", "categories": [ "Glycoproteomics" ] }, { "id": "A2A884", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=A2A884", "database": "O-GlcNAc Database", "categories": [ "Glycoproteomics" ] }, { "id": "EDRGPPN", "url": "https://omabrowser.org/oma/group/EDRGPPN/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "3353821at2759", "url": "http://www.orthodb.org/?query=3353821at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45944", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45944", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45944:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45944:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "http://pfam.xfam.org/family/PF00096", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_A2A884", "url": "http://purl.obolibrary.org/obo/PR_A2A884", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_034787", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034787", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A2A884", "url": "https://www.uniprot.org/uniprot/A2A884", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A2A884-1", "url": "https://www.uniprot.org/uniprot/A2A884-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F7D7H6", "url": "https://www.uniprot.org/uniprot/F7D7H6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F7D7H6-1", "url": "https://www.uniprot.org/uniprot/F7D7H6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDPDQSIKGTKKADGSPRKRLTKGEAIQTSVSSSAPYPGSGTTAPSESATQELLATQPFSGPSQEKTGQQQKPARRPSIEASVHISQLPQHPLTPAFMSPGKPEHLLEGSTWQLVDPMRPGPSGSFVAPGLHPQSQLLPSHASILPPEELPGIPKVFVPRPSQVSLKPAEEAHKKERKPQKPGKYICQYCSRPCAKPSVLQKHIRSHTGERPYPCGPCGFSFKTKSNLYKHRKSHAHRIKAGLASGSSSEMYPPGLEMERIPGEEFEEPTEGESTDSEEETGAASGPSTDVLPKPKHPLLSSSLYSSGSHGSSQERCSLSQSSTGPSLEDPAPFAEASSEHPLSHKPEDTHTIKQKLALRLSERKKLIEEQTFLSPGSKGSTESGYFSRSESAEQQVSPPNTNAKSYAEIIFGKCGRIGQRTSMLASTSTQPLLPLSSEDKPSLVPLSVPRTQVIEHITKLITINEAVVDTSEIDSVKPRRSSLTRRSSVESPKSSLYRDSLSSHGEKTKQEQSLLSLQHPPSSTHPVPLLRSHSMPSAACTISTHHHTFRGSYSFDDHVADPEVPSRNTPVFTSHPRMLKRQPAIELPLGGEYSSEEPGPSSKDPTSKPSDEPEPKESDLTKKTKKGFKTKGANYECTICGARYKKRDNYEAHKKYYCSELQITKAHSVGAHEVEKTQAEPEPWSQMMHYKLGATLELTPLRKRRKEKSLGDEEEPPAFGSPGPSETAHNRPLGSTKSPAEASKSAPSLEGPTSFQPRTPKPGAGSEPGKERRTMSKEISVIQHTSSFEKSDPPEQPSGLEEDKPPAQFSSPPPAPHGRSAHSLQPRLVRQPNIQVPEILVTEEPDRPDTEPEPPPKEPEKTEEFQWPQRSQTLAQLPAEKLPPKKKRLRLAEMAQSSGESSFESSVPLSRSPSQESSISLSGSSRSASFDREDHGKAEAPGPFSDTRSKTLGSHMLTVPSHHPHAREMRRSASEQSPNVPHSSHMTETRSKSFDYGSLSPTGPSLAVPAAPPPPAAPPERRKCFLVRQASLNRPPEAELEAVPKGKQESSEEPAASKPSTKSSVPQISVGTTQGGPSGGKSQMQDRPPLGSSPPYTEALQVFQPLGTQLPPPASLFSLQQLLPQEQEQSSEFFPTQAMAGLLSSPYSMPPLPPSLFQAPPLPLQPTVLHPSQLHLPQLLPHAADIPFQQPPSFLPMPCPAPSTLSGYFLPLQSQFALQLPGEIESHLPPVKTSLPPLATGPPGPSSSTEYSSDIQLPPVTPQATSPAPTSAPPLALPACPDAMVSLVVPVRIQTHMPSYGSAMYTTLSQILVTQSPGSPASTALTKYEEPSSKSMTVCEADVYEAEPGPSSISKEQNRGYQTPYLRVPERKGTSLSSEGILSLEGCSSTASGSKRVLSPAGSLELTMETQQQKRVKEEEASKADEKLELVSTCSVVLTSTEDRKKTEKPHVGGQGRSRREAETLSSLSSDVSDPKELSPLSHSTLSHGTAPGSEALKEYAQPSSKAHRRGLPPMSVKKEDPKEQTDLPPLAPPSSLPLSDTSPKPAKLQEGTDSKKVLQFPSLHTTTNVSWCYLNYIKPNHIQHADRRSSVYAGWCISLYNPNLPGVSTKAALSLLRSKQKVSKETYTMATAPHPEAGRLVPSNSRKPRMTEVHLPSLVSPESQKDPARVEKEEKQGKAEEGTPTSKRGEPARVKIFEGGYKSNEEYIYVRGRGRGRYVCEECGIRCKKPSMLKKHIRTHTDVRPYVCKHCHFAFKTKGNLTKHMKSKAHSKKCQETGVLEELEAEEGTSDDLHQDSEGQEGAEAVEEHQFSDLEDSDSDSDLDEDEEEEEEEEESQDELSGPCSEAAPPCLPPTLQENSSPVEGPQAPDSTSDEVPQGSSISEATHLTASSCSTPSRGTQGLPRLGLAPLEKDMSSAPSPKATSPRRPWSPSKEAGSRPSLTRKHSLTKNDSSPQQCSPAREAQASVTSTPGPQMGPGRDLGPHLCGSPRLELSCLTPYPIGREAPAGLERATDTGTPRYSPTRRWSLGQAESPPQTVLPGKWALAGPCSPSADKSGLGLGPVPRALLQPVPLPHTLLSRSPETCTSAWRKTESRSPSAGPAPLFPRPFSAPHDFHGHLPSRSEENLFSHLPLHSQLLSRAPCPLIPIGGIQMVQARPGAQPTVLPGPCAAWVSGFSGGGSDLTGAREAQERSRWSPTESPSASVSPVAKVSKFTLSSELEEERTGRGPGRPPDWEPHRAEAPPGPMGTHSPCSPQLPQGHQVAPSWRGLLGSPHTLANLKASSFPPLDRSSSMDCLAETSTYSPPRSRNLSGEPRTRQGSPELLGRGELRTPLFLPKGSGPPSI", "length": 2348, "header": "sp|A2A884-1|ZEP3_MOUSE Isoform 1 of Transcription factor HIVEP3 OS=Mus musculus OX=10090 GN=Hivep3 PE=1 SV=1 CANONICAL=A2A884-1" }, "isoforms": [ { "isoform_ac": "A2A884-1", "url": "https://www.uniprot.org/uniprotkb/A2A884/entry#A2A884-1", "sequence": { "sequence": "MDPDQSIKGTKKADGSPRKRLTKGEAIQTSVSSSAPYPGSGTTAPSESATQELLATQPFSGPSQEKTGQQQKPARRPSIEASVHISQLPQHPLTPAFMSPGKPEHLLEGSTWQLVDPMRPGPSGSFVAPGLHPQSQLLPSHASILPPEELPGIPKVFVPRPSQVSLKPAEEAHKKERKPQKPGKYICQYCSRPCAKPSVLQKHIRSHTGERPYPCGPCGFSFKTKSNLYKHRKSHAHRIKAGLASGSSSEMYPPGLEMERIPGEEFEEPTEGESTDSEEETGAASGPSTDVLPKPKHPLLSSSLYSSGSHGSSQERCSLSQSSTGPSLEDPAPFAEASSEHPLSHKPEDTHTIKQKLALRLSERKKLIEEQTFLSPGSKGSTESGYFSRSESAEQQVSPPNTNAKSYAEIIFGKCGRIGQRTSMLASTSTQPLLPLSSEDKPSLVPLSVPRTQVIEHITKLITINEAVVDTSEIDSVKPRRSSLTRRSSVESPKSSLYRDSLSSHGEKTKQEQSLLSLQHPPSSTHPVPLLRSHSMPSAACTISTHHHTFRGSYSFDDHVADPEVPSRNTPVFTSHPRMLKRQPAIELPLGGEYSSEEPGPSSKDPTSKPSDEPEPKESDLTKKTKKGFKTKGANYECTICGARYKKRDNYEAHKKYYCSELQITKAHSVGAHEVEKTQAEPEPWSQMMHYKLGATLELTPLRKRRKEKSLGDEEEPPAFGSPGPSETAHNRPLGSTKSPAEASKSAPSLEGPTSFQPRTPKPGAGSEPGKERRTMSKEISVIQHTSSFEKSDPPEQPSGLEEDKPPAQFSSPPPAPHGRSAHSLQPRLVRQPNIQVPEILVTEEPDRPDTEPEPPPKEPEKTEEFQWPQRSQTLAQLPAEKLPPKKKRLRLAEMAQSSGESSFESSVPLSRSPSQESSISLSGSSRSASFDREDHGKAEAPGPFSDTRSKTLGSHMLTVPSHHPHAREMRRSASEQSPNVPHSSHMTETRSKSFDYGSLSPTGPSLAVPAAPPPPAAPPERRKCFLVRQASLNRPPEAELEAVPKGKQESSEEPAASKPSTKSSVPQISVGTTQGGPSGGKSQMQDRPPLGSSPPYTEALQVFQPLGTQLPPPASLFSLQQLLPQEQEQSSEFFPTQAMAGLLSSPYSMPPLPPSLFQAPPLPLQPTVLHPSQLHLPQLLPHAADIPFQQPPSFLPMPCPAPSTLSGYFLPLQSQFALQLPGEIESHLPPVKTSLPPLATGPPGPSSSTEYSSDIQLPPVTPQATSPAPTSAPPLALPACPDAMVSLVVPVRIQTHMPSYGSAMYTTLSQILVTQSPGSPASTALTKYEEPSSKSMTVCEADVYEAEPGPSSISKEQNRGYQTPYLRVPERKGTSLSSEGILSLEGCSSTASGSKRVLSPAGSLELTMETQQQKRVKEEEASKADEKLELVSTCSVVLTSTEDRKKTEKPHVGGQGRSRREAETLSSLSSDVSDPKELSPLSHSTLSHGTAPGSEALKEYAQPSSKAHRRGLPPMSVKKEDPKEQTDLPPLAPPSSLPLSDTSPKPAKLQEGTDSKKVLQFPSLHTTTNVSWCYLNYIKPNHIQHADRRSSVYAGWCISLYNPNLPGVSTKAALSLLRSKQKVSKETYTMATAPHPEAGRLVPSNSRKPRMTEVHLPSLVSPESQKDPARVEKEEKQGKAEEGTPTSKRGEPARVKIFEGGYKSNEEYIYVRGRGRGRYVCEECGIRCKKPSMLKKHIRTHTDVRPYVCKHCHFAFKTKGNLTKHMKSKAHSKKCQETGVLEELEAEEGTSDDLHQDSEGQEGAEAVEEHQFSDLEDSDSDSDLDEDEEEEEEEEESQDELSGPCSEAAPPCLPPTLQENSSPVEGPQAPDSTSDEVPQGSSISEATHLTASSCSTPSRGTQGLPRLGLAPLEKDMSSAPSPKATSPRRPWSPSKEAGSRPSLTRKHSLTKNDSSPQQCSPAREAQASVTSTPGPQMGPGRDLGPHLCGSPRLELSCLTPYPIGREAPAGLERATDTGTPRYSPTRRWSLGQAESPPQTVLPGKWALAGPCSPSADKSGLGLGPVPRALLQPVPLPHTLLSRSPETCTSAWRKTESRSPSAGPAPLFPRPFSAPHDFHGHLPSRSEENLFSHLPLHSQLLSRAPCPLIPIGGIQMVQARPGAQPTVLPGPCAAWVSGFSGGGSDLTGAREAQERSRWSPTESPSASVSPVAKVSKFTLSSELEEERTGRGPGRPPDWEPHRAEAPPGPMGTHSPCSPQLPQGHQVAPSWRGLLGSPHTLANLKASSFPPLDRSSSMDCLAETSTYSPPRSRNLSGEPRTRQGSPELLGRGELRTPLFLPKGSGPPSI", "length": 2348, "header": "sp|A2A884-1|ZEP3_MOUSE Isoform 1 of Transcription factor HIVEP3 OS=Mus musculus OX=10090 GN=Hivep3 PE=1 SV=1 CANONICAL=A2A884-1" }, "locus": { "chromosome": "4", "start_pos": 119991545, "end_pos": 119951686, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000106307.9", "url": "https://www.ensembl.org/id/ENSMUST00000106307.9" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000101914.3", "url": "https://www.ensembl.org/id/ENSMUSP00000101914.3" } ] } }, { "isoform_ac": "F7D7H6-1", "url": "https://www.uniprot.org/uniprotkb/A2A884/entry#F7D7H6-1", "sequence": { "sequence": "VGARRRGCSHAGPLEQPQRSAQVRPPRRSANASLGTSCPRPRAVSAPHRPGGGPVAYPPPRRPADPDCPPIRRDAGLGARVPHLSPCCTRGQISETRRNPGRGKFVDIGAPRGAGS", "length": 116, "header": "tr|F7D7H6-1|F7D7H6_MOUSE Computationally mapped isoform of Human immunodeficiency virus type I enhancer binding protein 3 OS=Mus musculus OX=10090 GN=Hivep3 PE=4 SV=1 CANONICAL=A2A884-1" }, "locus": { "chromosome": "4", "start_pos": 119591341, "end_pos": 119590994, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000084306.5", "url": "https://www.ensembl.org/id/ENSMUST00000084306.5" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000081330.5", "url": "https://www.ensembl.org/id/ENSMUSP00000081330.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 1073, "start_aa": "Thr", "end_pos": 1073, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1073", "evidence": [ { "id": "32848054", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32848054" }, { "id": "A2A884", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/A2A884" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 1074, "start_aa": "Thr", "end_pos": 1074, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1074", "evidence": [ { "id": "32848054", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32848054" }, { "id": "A2A884", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/A2A884" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 452, "start_aa": "Thr", "end_pos": 452, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr452", "evidence": [ { "id": "22517741", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/22517741" }, { "id": "A2A884", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=A2A884" }, { "id": "22645316", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/22645316" }, { "id": "36084651", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/36084651" }, { "id": "A2A884", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/A2A884" } ] } ], "phosphorylation": [ { "start_pos": 1400, "end_pos": 1400, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "A2A884", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2A884" } ], "site_lbl": "Ser1400" }, { "start_pos": 1404, "end_pos": 1404, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "A2A884", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2A884" } ], "site_lbl": "Ser1404" }, { "start_pos": 1459, "end_pos": 1459, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "A2A884", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2A884" } ], "site_lbl": "Ser1459" }, { "start_pos": 1474, "end_pos": 1474, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "A2A884", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2A884" } ], "site_lbl": "Ser1474" }, { "start_pos": 1480, "end_pos": 1480, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "A2A884", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2A884" } ], "site_lbl": "Ser1480" }, { "start_pos": 1483, "end_pos": 1483, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "A2A884", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2A884" } ], "site_lbl": "Ser1483" }, { "start_pos": 1486, "end_pos": 1486, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "A2A884", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2A884" } ], "site_lbl": "Thr1486" }, { "start_pos": 1647, "end_pos": 1647, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "A2A884", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2A884" } ], "site_lbl": "Ser1647" }, { "start_pos": 1933, "end_pos": 1933, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "A2A884", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2A884" } ], "site_lbl": "Ser1933" }, { "start_pos": 1949, "end_pos": 1949, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "A2A884", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2A884" } ], "site_lbl": "Ser1949" }, { "start_pos": 1961, "end_pos": 1961, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "A2A884", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2A884" } ], "site_lbl": "Ser1961" }, { "start_pos": 1991, "end_pos": 1991, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "A2A884", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2A884" } ], "site_lbl": "Ser1991" }, { "start_pos": 2030, "end_pos": 2030, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "A2A884", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2A884" } ], "site_lbl": "Ser2030" }, { "start_pos": 2036, "end_pos": 2036, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "A2A884", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2A884" } ], "site_lbl": "Ser2036" }, { "start_pos": 2055, "end_pos": 2055, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "A2A884", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2A884" } ], "site_lbl": "Ser2055" }, { "start_pos": 2199, "end_pos": 2199, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "A2A884", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2A884" } ], "site_lbl": "Ser2199" }, { "start_pos": 2201, "end_pos": 2201, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "A2A884", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2A884" } ], "site_lbl": "Thr2201" }, { "start_pos": 2209, "end_pos": 2209, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "A2A884", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2A884" } ], "site_lbl": "Ser2209" }, { "start_pos": 2276, "end_pos": 2276, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "A2A884", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2A884" } ], "site_lbl": "Ser2276" }, { "start_pos": 2307, "end_pos": 2307, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "A2A884", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2A884" } ], "site_lbl": "Ser2307" }, { "start_pos": 2315, "end_pos": 2315, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "A2A884", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2A884" } ], "site_lbl": "Ser2315" }, { "start_pos": 2324, "end_pos": 2324, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "A2A884", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2A884" } ], "site_lbl": "Ser2324" }, { "start_pos": 305, "end_pos": 305, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "A2A884", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2A884" } ], "site_lbl": "Tyr305" }, { "start_pos": 306, "end_pos": 306, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "A2A884", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2A884" } ], "site_lbl": "Ser306" }, { "start_pos": 307, "end_pos": 307, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "A2A884", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2A884" } ], "site_lbl": "Ser307" }, { "start_pos": 312, "end_pos": 312, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "A2A884", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2A884" } ], "site_lbl": "Ser312" }, { "start_pos": 362, "end_pos": 362, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "A2A884", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2A884" } ], "site_lbl": "Ser362" }, { "start_pos": 375, "end_pos": 375, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "A2A884", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2A884" } ], "site_lbl": "Ser375" }, { "start_pos": 489, "end_pos": 489, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "A2A884", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2A884" } ], "site_lbl": "Ser489" }, { "start_pos": 555, "end_pos": 555, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "A2A884", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2A884" } ], "site_lbl": "Ser555" }, { "start_pos": 78, "end_pos": 78, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "A2A884", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2A884" } ], "site_lbl": "Ser78" }, { "start_pos": 792, "end_pos": 792, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "A2A884", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2A884" } ], "site_lbl": "Ser792" }, { "start_pos": 915, "end_pos": 915, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "A2A884", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2A884" } ], "site_lbl": "Ser915" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "The kappaB and V(D)J recombination signal sequence binding protein KRC regulates transcription of the mouse metastasis-associated gene S100A4/mts1.", "journal": "The Journal of biological chemistry", "date": "2000", "authors": "Hjelmsoe I, Allen CE, Cohn MA, Tulchinsky EM, Wu LC", "evidence": [ { "database": "UniProtKB", "id": "A2A884", "url": "https://www.uniprot.org/uniprot/A2A884" } ], "reference": [ { "type": "PubMed", "id": "10625627", "url": "https://glygen.org/publication/PubMed/10625627" } ] }, { "title": "Downregulation of KRC induces proliferation, anchorage independence, and mitotic cell death in HeLa cells.", "journal": "Experimental cell research", "date": "2000-11-01", "authors": "Allen C E, Wu L C", "evidence": [ { "database": "UniProtKB", "id": "A2A884", "url": "https://www.uniprot.org/uniprot/A2A884" } ], "reference": [ { "type": "PubMed", "id": "11035930", "url": "https://glygen.org/publication/PubMed/11035930" } ] }, { "title": "A mammalian homolog of Drosophila schnurri, KRC, regulates TNF receptor-driven responses and interacts with TRAF2.", "journal": "Molecular cell", "date": "2002", "authors": "Oukka M, Kim ST, Lugo G, Sun J, Wu LC, Glimcher LH", "evidence": [ { "database": "UniProtKB", "id": "A2A884", "url": "https://www.uniprot.org/uniprot/A2A884" }, { "database": "RefSeq", "id": "NP_034787", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034787" } ], "reference": [ { "type": "PubMed", "id": "11804591", "url": "https://glygen.org/publication/PubMed/11804591" } ] }, { "title": "Embryonic expression and regulation of the large zinc finger protein KRC.", "journal": "Genesis (New York, N.Y. : 2000)", "date": "2002-05", "authors": "Hicar Mark D, Robinson Michael L, Wu Lai-Chu", "evidence": [ { "database": "UniProtKB", "id": "A2A884", "url": "https://www.uniprot.org/uniprot/A2A884" } ], "reference": [ { "type": "PubMed", "id": "12001065", "url": "https://glygen.org/publication/PubMed/12001065" } ] }, { "title": "The kappa B transcriptional enhancer motif and signal sequences of V(D)J recombination are targets for the zinc finger protein HIVEP3/KRC: a site selection amplification binding study.", "journal": "BMC immunology", "date": "2002-08-22", "authors": "Allen Carl E, Mak Chi-ho, Wu Lai-Chu", "evidence": [ { "database": "UniProtKB", "id": "A2A884", "url": "https://www.uniprot.org/uniprot/A2A884" } ], "reference": [ { "type": "PubMed", "id": "12193271", "url": "https://glygen.org/publication/PubMed/12193271" } ] }, { "title": "Inhibition of NF-kappaB by ZAS3, a zinc-finger protein that also binds to the kappaB motif.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2003-10-14", "authors": "Hong Joung-Woo, Allen Carl E, Wu Lai-Chu", "evidence": [ { "database": "UniProtKB", "id": "A2A884", "url": "https://www.uniprot.org/uniprot/A2A884" } ], "reference": [ { "type": "PubMed", "id": "14530385", "url": "https://glygen.org/publication/PubMed/14530385" } ] }, { "title": "Schnurri-3 (KRC) interacts with c-Jun to regulate the IL-2 gene in T cells.", "journal": "The Journal of experimental medicine", "date": "2004", "authors": "Oukka M, Wein MN, Glimcher LH", "evidence": [ { "database": "UniProtKB", "id": "A2A884", "url": "https://www.uniprot.org/uniprot/A2A884" } ], "reference": [ { "type": "PubMed", "id": "14707112", "url": "https://glygen.org/publication/PubMed/14707112" } ] }, { "title": "Structural characterization of the gene encoding the large zinc finger protein ZAS3: implication to the origin of multiple promoters in eukaryotic genes.", "journal": "Biochim. Biophys. Acta", "date": "2005", "authors": "Hong Joung-Woo, Wu Lai-Chu", "evidence": [ { "database": "UniProtKB", "id": "A2A884", "url": "https://www.uniprot.org/uniprot/A2A884" } ], "reference": [ { "type": "PubMed", "id": "15627499", "url": "https://glygen.org/publication/PubMed/15627499" } ] }, { "title": "Regulation of adult bone mass by the zinc finger adapter protein Schnurri-3.", "journal": "Science", "date": "2006", "authors": "Jones DC, Wein MN, Oukka M, Hofstaetter JG, Glimcher MJ, Glimcher LH", "evidence": [ { "database": "UniProtKB", "id": "A2A884", "url": "https://www.uniprot.org/uniprot/A2A884" } ], "reference": [ { "type": "PubMed", "id": "16728642", "url": "https://glygen.org/publication/PubMed/16728642" } ] }, { "title": "Tandem mass spectrometry identifies many mouse brain O-GlcNAcylated proteins including EGF domain-specific O-GlcNAc transferase targets.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2012", "authors": "Alfaro JF, Gong CX, Monroe ME, Aldrich JT, Clauss TR, Purvine SO, Wang Z, Camp DG 2nd, Shabanowitz J, Stanley P, Hart GW, Hunt DF, Yang F, Smith RD", "evidence": [ { "database": "O-GlcNAc Database", "id": "A2A884", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=A2A884" } ], "reference": [ { "type": "PubMed", "id": "22517741", "url": "https://glygen.org/publication/PubMed/22517741" } ] }, { "title": "Global identification and characterization of both O-GlcNAcylation and phosphorylation at the murine synapse.", "journal": "Molecular & cellular proteomics : MCP", "date": "2012", "authors": "Trinidad JC, Barkan DT, Gulledge BF, Thalhammer A, Sali A, Schoepfer R, Burlingame AL", "evidence": [ { "database": "O-GlcNAc Database", "id": "A2A884", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=A2A884" }, { "database": "O-GlcNAc Atlas", "id": "A2A884", "url": "https://oglcnac.org/atlas/detail/A2A884" } ], "reference": [ { "type": "PubMed", "id": "22645316", "url": "https://glygen.org/publication/PubMed/22645316" } ] }, { "title": "Age-related loss of neural stem cell O-GlcNAc promotes a glial fate switch through STAT3 activation.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2020", "authors": "White CW 3rd, Fan X, Maynard JC, Wheatley EG, Bieri G, Couthouis J, Burlingame AL, Villeda SA", "evidence": [ { "database": "O-GlcNAc Atlas", "id": "A2A884", "url": "https://oglcnac.org/atlas/detail/A2A884" } ], "reference": [ { "type": "PubMed", "id": "32848054", "url": "https://glygen.org/publication/PubMed/32848054" } ] }, { "title": "Increased glucose metabolism in TAMs fuels O-GlcNAcylation of lysosomal Cathepsin B to promote cancer metastasis and chemoresistance.", "journal": "Cancer cell", "date": "2022-10-10", "authors": "Shi Qingzhu, Shen Qicong, Liu Yanfang, Shi Yang, Huang Wenwen, Wang Xi, Li Zhiqing, Chai Yangyang, Wang Hao, Hu Xiangjia, Li Nan, Zhang Qian, Cao Xuetao", "evidence": [ { "database": "O-GlcNAc Database", "id": "A2A884", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=A2A884" } ], "reference": [ { "type": "PubMed", "id": "36084651", "url": "https://glygen.org/publication/PubMed/36084651" } ] }, { "title": "Schnurri-3 inhibition suppresses bone and joint damage in models of rheumatoid arthritis.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2023-05-09", "authors": "Stavre Zheni, Kim Jung-Min, Yang Yeon-Suk, N\u00fcndel Kerstin, Chaugule Sachin, Sato Tadatoshi, Park Kwang Hwan, Gao Guangping, Gravallese Ellen M, Shim Jae-Hyuck", "evidence": [ { "database": "RefSeq", "id": "NP_034787", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034787" } ], "reference": [ { "type": "PubMed", "id": "37141171", "url": "https://glygen.org/publication/PubMed/37141171" } ] }, { "title": "Schnurri-3 drives tumor growth and invasion in cancer cells expressing interleukin-13 receptor alpha 2.", "journal": "Cell death & disease", "date": "2023-11-14", "authors": "Bartolom\u00e9 Rub\u00e9n A, Mart\u00edn-Regalado \u00c1ngela, Pintado-Berninches Laura, Robles Javier, Ram\u00edrez-Gonz\u00e1lez M\u00aa \u00c1ngeles, Boukich Issam, Sanchez-G\u00f3mez Pilar, Balyasnikova Irina V, Casal J Ignacio", "evidence": [ { "database": "RefSeq", "id": "NP_034787", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034787" } ], "reference": [ { "type": "PubMed", "id": "37963919", "url": "https://glygen.org/publication/PubMed/37963919" } ] }, { "title": "Molecular cloning of a zinc finger protein which binds to the heptamer of the signal sequence for V(D)J recombination.", "journal": "Nucleic acids research", "date": "1993", "authors": "Wu LC, Mak CH, Dear N, Boehm T, Foroni L, Rabbitts TH", "evidence": [ { "database": "UniProtKB", "id": "A2A884", "url": "https://www.uniprot.org/uniprot/A2A884" } ], "reference": [ { "type": "PubMed", "id": "8255760", "url": "https://glygen.org/publication/PubMed/8255760" } ] }, { "title": "The mouse DNA binding protein Rc for the kappa B motif of transcription and for the V(D)J recombination signal sequences contains composite DNA-protein interaction domains and belongs to a new family of large transcriptional proteins.", "journal": "Genomics", "date": "1996", "authors": "Wu LC, Liu Y, Strandtmann J, Mak CH, Lee B, Li Z, Yu CY", "evidence": [ { "database": "UniProtKB", "id": "A2A884", "url": "https://www.uniprot.org/uniprot/A2A884" } ], "reference": [ { "type": "PubMed", "id": "8812474", "url": "https://glygen.org/publication/PubMed/8812474" } ] }, { "title": "Regulation by phosphorylation of the zinc finger protein KRC that binds the kappaB motif and V(D)J recombination signal sequences.", "journal": "Nucleic acids research", "date": "1999", "authors": "Bachmeyer C, Mak CH, Yu CY, Wu LC", "evidence": [ { "database": "UniProtKB", "id": "A2A884", "url": "https://www.uniprot.org/uniprot/A2A884" } ], "reference": [ { "type": "PubMed", "id": "9862992", "url": "https://glygen.org/publication/PubMed/9862992" } ] } ], "pathway": [ { "id": "mmu:16656", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:16656", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "D3ZRB5-1", "protein_name": "HIVEP zinc finger 3", "gene_name": "Hivep3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSPSKPEHLLEGSTWQLVDPTRPGPSGSFVAPGLHPQSQLLPSHASILPPEDLPGIPKVFVPRPSQVSLKPTEEAHKKERKPQKPGKYICQYCSRPCAKPSVLQKHIRSHTGERPYPCGPCGFSFKTKSNLYKHRKSHAHRIKAGLASGSSSEMYPPGLEMERIPGEEFEEPTEGESTDSEEETGATSGPSTDVLPKSKHPLLSSSLYSSGSHGSSQERCSQSSTAPSLEDPTPFAEASSEHPLSHKLEDTHTIKQKLALRLSERKKLIEEQTFLSPGSKGSTESGYFSRSESAEQQVSPPNTNAKSYAEIIFGKCGRIGQRTSMLASTSTQPLLPLSAEDKPSLVPLSVPRTQVIEHITKLITINEAVVDTSEIDSVKPRRSSLTRRSSVESPKSSLYRESLSSHGEKTKQEQSLLSLQHPPSSTHPVPLLRSHSMPSAACTISTHHHTFRGSYSFDDHIADPEVPSRSTPVFTSHPRMLKRQPAIELPLGAEYSSEEPGPSSKDPITKPSDEPEPKESDLTKKTKKGLKTKGVNYECTICGARYKKRDNYEAHKKYYCSELQITKAHPAGAHEVEKTQAEPEPWSQMMHYKLGATLELTPLRKRRKEKSLGDEEEPPGFSSPGPSDAAHNLPLESTKSPAEASKSVPTLEGPTSFQPRTPKPGSGSEPGKERRTMSKEISVIQHTSSFEKSDPPEQPGSLEEDKPLAPFSSPPPAPHGRSAHSLQPRLVRQPNIQVPEILVTEEPDRPDTEPEPPPKEPEKTEEFQWPQRSQTLAQLPAEKLPPKKKRLRLAEMAQSSGESSFESSVPLSRSPSQESSISLSGSSRSASFDREDHGKAETPGPLSDTRSKTLGTHMLTVPSHHPHAREMRRSASEQSPNVPHSSHMTETRSKSFDYGSLSPTGPSVAVPAAPPPPAAPPERRKCFLVRQASLSRPPEAELEATPKGKQESSEEPSASKPSTKSSMAQISVATIQGGLSGSKSQMQDRPPLGSSPPYTEALQVFQPLGTQLPPPVSLFSLQQLLPQEQEQSSEFFPTQAMAGLLSSPYSVPPLPPSLFQAPPLPLQPTVLHPSQLHLPQLLPHAADIPFQQPPSFLPMPCPAPSTLSGYFLPLQSQFALQLPGEIESHLPSIKTSLPPLATGPPGPSSSTEYSSDIQLPPVTPQATSPAPTSASPLALPACPDAMVSLVVPVRIQTHMPSYGSAMYTTLSQILVTQSPGSSTSMALTKYEEPSSKSMTVCGADVYEAEPGPSSISKEQSRGFQTPYLRVPERKGTALSSEGILSLEGCSSTASGSKRVLSPAGSLELTMETQQQKRVKEEEASKADEKLELVSTCNVVLTSTEDRKKTEKPHVGSQGRSRRETETLSCLSSDVSDPKELSPLSQSTLSHGTAPGSEALKEYAQPSSKAHRRCLPPLSVKKEDPKEQTDLPPLAPPSSLPLSDTSPRPAKLQEGTDSKKVLQFPSLHTTTNVSWCYLNYIKPNHIQHADRRSSVYAGWCISLYNPNLPGVSTKAALSLLRSKQKVSKETYTMATAPHPEAGRLVPSNSRKPRMTEVHLPSMVSLESQKDPARVEKEEKAEEGTPTSKRGEPTRVKIFEGGYKSNEEYIYVRGRGRGKYVCEECGIRCKKPSMLKKHIRTHTDVRPYVCRHCHFAFKTKGNLTKHMKSKAHSKKCQETGVLEELEAEEGTSDDLLQDSEGREGSEAVEEHQFSDLEDSDSDSDLDEDEEEEEEEEEESQDELSRPSSEAAPLCLPATLQEDSSLIRGPQPPDATSDAAPRGSSISEATRLTASSCSTPSQGTQGLPRLGLAPLEKGTSSALSPKATSPRRPWSPSKEAGSRPSLTRKHSLTKTDSSPQRCSPARAQASVASTPGPQTGPGRDLSPHLCGSPRPELSCLTPYPIGREVPAGLESATVTGTPRCSPTRRRSLGRAESSPPHTVLPGTWALGGPCSPSVDKYGLGLGPVPRALLQPVPLPHTLLSRSPETCASAWTESRSPSAGPAPLSSRPSSAPHDFHGHLPSRSEENLFSHLPLHSQHLNRTPCPLIPIGGIQMVQARPGAHPTLLSGPCAAWVSGFSGGGSDLTGAREAQERSRWSPTESPSASVSPVAKVSKFTLSSELEEERTSRGPGRPPAWEPHRAEAPAETMGTHSPCPPQLPQGHPLAPSWRGLLESPHALANLKASSFPPLDRSSSMDCLAETSTCFPPRSRNLSGEPRTRPDSPELLGSGELRTPLFLSKDSGPPSI", "length": 2245 }, "evidence": [ { "id": "A2A884", "url": "https://omabrowser.org/oma/group/A2A884/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q5T1R4-1", "protein_name": "Transcription factor HIVEP3", "gene_name": "HIVEP3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDPEQSVKGTKKAEGSPRKRLTKGEAIQTSVSSSVPYPGSGTAATQESPAQELLAPQPFPGPSSVLREGSQEKTGQQQKPPKRPPIEASVHISQLPQHPLTPAFMSPGKPEHLLEGSTWQLVDPMRPGPSGSFVAPGLHPQSQLLPSHASIIPPEDLPGVPKVFVPRPSQVSLKPTEEAHKKERKPQKPGKYICQYCSRPCAKPSVLQKHIRSHTGERPYPCGPCGFSFKTKSNLYKHRKSHAHRIKAGLASGMGGEMYPHGLEMERIPGEEFEEPTEGESTDSEEETSATSGHPAELSPRPKQPLLSSGLYSSGSHSSSHERCSLSQSSTAQSLEDPPPFVEPSSEHPLSHKPEDTHTIKQKLALRLSERKKVIDEQAFLSPGSKGSTESGYFSRSESAEQQVSPPNTNAKSYAEIIFGKCGRIGQRTAMLTATSTQPLLPLSTEDKPSLVPLSVPRTQVIEHITKLITINEAVVDTSEIDSVKPRRSSLSRRSSMESPKSSLYREPLSSHSEKTKPEQSLLSLQHPPSTAPPVPLLRSHSMPSAACTISTPHHPFRGSYSFDDHITDSEALSHSSHVFTSHPRMLKRQPAIELPLGGEYSSEEPGPSSKDTASKPSDEVEPKESELTKKTKKGLKTKGVIYECNICGARYKKRDNYEAHKKYYCSELQIAKPISAGTHTSPEAEKSQIEHEPWSQMMHYKLGTTLELTPLRKRRKEKSLGDEEEPPAFESTKSQFGSPGPSDAARNLPLESTKSPAEPSKSVPSLEGPTGFQPRTPKPGSGSESGKERRTTSKEISVIQHTSSFEKSDSLEQPSGLEGEDKPLAQFPSPPPAPHGRSAHSLQPKLVRQPNIQVPEILVTEEPDRPDTEPEPPPKEPEKTEEFQWPQRSQTLAQLPAEKLPPKKKRLRLAEMAQSSGESSFESSVPLSRSPSQESNVSLSGSSRSASFERDDHGKAEAPSPSSDMRPKPLGTHMLTVPSHHPHAREMRRSASEQSPNVSHSAHMTETRSKSFDYGSLSLTGPSAPAPVAPPARVAPPERRKCFLVRQASLSRPPESELEVAPKGRQESEEPQPSSSKPSAKSSLSQISSAATSHGGPPGGKGPGQDRPPLGPTVPYTEALQVFHHPVAQTPLHEKPYLPPPVSLFSFQHLVQHEPGQSPEFFSTQAMSSLLSSPYSMPPLPPSLFQAPPLPLQPTVLHPGQLHLPQLMPHPANIPFRQPPSFLPMPYPTSSALSSGFFLPLQSQFALQLPGDVESHLPQIKTSLAPLATGSAGLSPSTEYSSDIRLPPVAPPASSSAPTSAPPLALPACPDTMVSLVVPVRVQTNMPSYGSAMYTTLSQILVTQSQGSSATVALPKFEEPPSKGTTVCGADVHEVGPGPSGLSEEQSRAFPTPYLRVPVTLPERKGTSLSSESILSLEGSSSTAGGSKRVLSPAGSLELTMETQQQKRVKEEEASKADEKLELVKPCSVVLTSTEDGKRPEKSHLGNQGQGRRELEMLSSLSSDPSDTKEIPPLPHPALSHGTAPGSEALKEYPQPSGKPHRRGLTPLSVKKEDSKEQPDLPSLAPPSSLPLSETSSRPAKSQEGTDSKKVLQFPSLHTTTNVSWCYLNYIKPNHIQHADRRSSVYAGWCISLYNPNLPGVSTKAALSLLRSKQKVSKETYTMATAPHPEAGRLVPSSSRKPRMTEVHLPSLVSPEGQKDLARVEKEEERRGEPEEDAPASQRGEPARIKIFEGGYKSNEEYVYVRGRGRGKYVCEECGIRCKKPSMLKKHIRTHTDVRPYVCKHCHFAFKTKGNLTKHMKSKAHSKKCQETGVLEELEAEEGTSDDLFQDSEGREGSEAVEEHQFSDLEDSDSDSDLDEDEDEDEEESQDELSRPSSEAPPPGPPHALRADSSPILGPQPPDAPASGTEATRGSSVSEAERLTASSCSMSSQSMPGLPWLGPAPLGSVEKDTGSALSYKPVSPRRPWSPSKEAGSRPPLARKHSLTKNDSSPQRCSPAREPQASAPSPPGLHVDPGRGMGALPCGSPRLQLSPLTLCPLGRELAPRAHVLSKLEGTTDPGLPRYSPTRRWSPGQAESPPRSAPPGKWALAGPGSPSAGEHGPGLGLDPRVLFPPAPLPHKLLSRSPETCASPWQKAESRSPSCSPGPAHPLSSRPFSALHDFHGHILARTEENIFSHLPLHSQHLTRAPCPLIPIGGIQMVQARPGAHPTLLPGPTAAWVSGFSGGGSDLTGAREAQERGRWSPTESSSASVSPVAKVSKFTLSSELEGGDYPKERERTGGGPGRPPDWTPHGTGAPAEPTPTHSPCTPPDTLPRPPQGRRAAQSWSPRLESPRAPTNPEPSATPPLDRSSSVGCLAEASARFPARTRNLSGEPRTRQDSPKPSGSGEPRAHPHQPEDRVPPNA", "length": 2406 }, "evidence": [ { "id": "46368200", "url": "http://www.informatics.jax.org/homology/46368200", "database": "MGI" }, { "id": "A2A884", "url": "https://omabrowser.org/oma/group/A2A884/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "R4GH84-1", "protein_name": "HIVEP zinc finger 3", "gene_name": "HIVEP3", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MDPEQSQKSTKKAEESPRKRLPKGEAFQASISSAATYQGSSASSQGTPLRDLISQQHFSGSLPIPREESQEKTGHQKQPKPSSFEHPPHVSQLQQHALSPAFMSPGKPEHVLEGPTWQLVDPVRPGPSGSFPSPGLHAHHGQILPSHSPIIPGEDMPSVQKVYIPRPSQVPLKQAEEVHKKEKKPQKPGKYICQYCSRPCAKPSVLQKHIRSHTGERPYPCIPCGFSFKTKSNLYKHRKSHAHRIKAGLASGIGAEMYPSSLEMERIGGEDFEEPTEGESTDSEEETGAMSGHPAELSPRQKHTLLSSSLLSAGSQGSSHDRCSLSHSSMSQSLEDSSQFAEPPSDQALSHKSEDTHTIKQKLALRLSERKKVIDEQAFLSPGSKGSTESGYFSRSESAEQQISPPNTNAKSYAEIIFGKCGRIGQRTAMLSTNTTQGFPHLSTEEKPSMVPLSVPRTQVIEHITKLITINEAVVDTSEIDSVKPRRSSLSRRSSIESPKSAAYREPFQFDIKSGSSSQLDASKALTSHGEKMKPEQSLLSLQQSHSATETVPLLRSHSMPSAACTISSPHTFRGSYSFDDHIMEPEVLSRSQAFSSHPRMLKRQPAIELPLGVEYVTEEVSSASKETVSKPPEEPETKESDLTKKSRKGPKVKGFMYECNVCGARYKKRDNYEAHKKYYCSELQLSKPRSSTSHTSSETEKNVMDPETWPQVMHYKLGSTLELTPLRKRRKEKSLGDDEDPPAFELSDTPSSSTGPGAQFANLASSDVALNLTRESMKSPADPGKSAPSDVSASFHSRNTKLVSSTEGKERRTTSKEISVIQHTSSFEKSDSIEQVSGLEGEEKPTPQYPSQPTTQHSRPHHSLQPKLVRQPNIQVPEILVTEEPDRPETEPEPPPKEPEKTEEFQWPQRSQTLSQLPAEKLPPKKKRLRLAEMAQSSGESSFESVSLTRSPSQESSVSHGSSHSVSFDREDHSKTEPGSQPPESHSKPPGVGSHMLMVPSHHHHHSREMRRSASEQTPNVSHVSQMSETRSKSFDYGSLSSTPASTPGPSTSSAPQERRKCFLVRQASLTRHPEHEPDPAPAGRPEAEDPVPSLSKSPSTSLPHQPPSSSPLPSHGTYPSDKSQPKDSPQPAYTQPYTEALQVFHPVPQLTLHEKHFLSPQVSIFPYQPLLPQPGQPAELFAAHTMSDLLSAQLTVPQLPPSIFQTPPLPLQQTLLHPGPLHLAPPLIPHPTEVPFRQHPSFLPVHYPSSSPISSAFFLPLQSQFALQLPEAGGHLPQLKSSLFPAAGTSSLSPCTEYSSDTRLYPLTRTTSPSVPVSTAQLIVPTRSDPVVSLVVPVRIQTNMPSYGSAMYTTLSQILVTQSQCSSSSIVLPKFDDCQPKGTLVCSADVHGLGFDLAQMITEEQRIFQSPYLRVPLPLPERKGCIPLTSPADSVLGLEGGPSTVGGSKRMLSPAGSLELTMETQQQKRVKEEEVSEAEEKLEVVKPPSAIEEGKKQDKAHFLTESQGRVEVETPPSLSLEQSELKETPSTLQQAVSRSGSPSFEALEEYQQPAGKQPLGKAPLQSVKKEDSKEPVEQPPPSPPSPAPLSEVPSSAMKSREGTDMKKVLQFPSLHTTTNVSWCYLNYIKPNHIQQVDRRSSVYASWCISLYNPNLPGISTKVALSLLRSKQKVSRETYTMATAPRPEAGRLVPSSSRKPKMTEVHLPSLLSNEGRKEITRAEKEEDKRGKPEEEAVVTKRGEPVRIKIFEGGYKSNEEYVYVRGRGRGKYVCEECGIRCKKPSMLKKHIRTHTDVRPYVCKYCNFAFKTKGNLTKHMKSKAHSKKCQEMGVLVSSLVDLEAEEGTSEDLFQDSEGREGSEPIEEHQFSDLEESDDDDDNEDDEDEEEEESQDEPPLKLPEAKHPTPLMHSSGGSPTSQEEGTETASSLAQETASSSQKVGEGQQGSSCGLETRWSADSSDIAVCHSILSLHRPALTSTEQLASAERESVTRPPMSLAMELSASKDTSPRKRWSPSQDSSRAGGSSRPMLARKHLLTKNETSPKRFSPTGEMSPLRCLSPGRGLSPCPRVSPRREASPLRCVSPRLELSPSRHLSPRRELSPRAYLPPEGEASSPSREMPSGRYLSLKKTLPPSCSEAPRYPSPGKEDAPGTSRSAADDKIQSSYQAQHGILSSMPLPHRFFGKNVQLYESKLKIEPRSPPRSPGTMQPICFRPLQAPHELHTHSRGEENVFSHLPLHSQQLARTPYPMIPIGGIQMVQARPSTHPSSVMSLPGGHFSPGGSSFEEPWVPREPSSASVSPVAKVSKYTLSPEPTSSECLEEKMRTSELKQKPDPEEYRVKVFAEPSPAEQPGRSASPANPSTTRQPSPKPSTSGDDPLTNPGEKQCGSSSSPLESPHCTFTSELPSPPPPRSLQPSGEPHRAPRSPRAEPTGVGHAQTEADDSTGSA", "length": 2448 }, "evidence": [ { "id": "A2A884", "url": "https://omabrowser.org/oma/group/A2A884/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A2A884", "url": "https://www.uniprot.org/uniprot/A2A884" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "A2A884", "url": "https://www.uniprot.org/uniprot/A2A884" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "A2A884", "url": "https://www.uniprot.org/uniprot/A2A884" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "A2A884", "url": "https://www.uniprot.org/uniprot/A2A884" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A2A884", "url": "https://www.uniprot.org/uniprot/A2A884" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A2A884", "url": "https://www.uniprot.org/uniprot/A2A884" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "A2A884", "url": "https://www.uniprot.org/uniprot/A2A884" } ], "pmid": "" }, { "name": "positive regulation of DNA-templated transcription", "id": "GO:0045893", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045893", "evidence": [ { "database": "UniProtKB", "id": "A2A884", "url": "https://www.uniprot.org/uniprot/A2A884" } ], "pmid": "" }, { "name": "skeletal muscle cell differentiation", "id": "GO:0035914", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035914", "evidence": [ { "database": "UniProtKB", "id": "A2A884", "url": "https://www.uniprot.org/uniprot/A2A884" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1570, "end_pos": 1572, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1762, "end_pos": 1764, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1861, "end_pos": 1863, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1953, "end_pos": 1955, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2313, "end_pos": 2315, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [ { "annotation": "Phosphorylated on threonine and serine residues. Phosphorylation by cyclin-dependent kinase CDK1 decreases HIVEP3 DNA binding affinity, and by epidermal growth factor receptor kinase increases its DNA binding affinity.", "evidence": [ { "database": "UniProtKB", "id": "A2A884", "url": "https://www.uniprot.org/uniprot/A2A884" }, { "database": "PubMed", "id": "9862992", "url": "https://glygen.org/publication/PubMed/9862992" } ] } ], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 452, 1073, 1074 ], "snv_sites": [ 533 ], "glycation_sites": [], "phosphorylation_sites": [ 78, 305, 306, 307, 312, 362, 375, 489, 555, 792, 915, 1400, 1404, 1459, 1474, 1480, 1483, 1486, 1647, 1933, 1949, 1961, 1991, 2030, 2036, 2055, 2199, 2201, 2209, 2276, 2307, 2315, 2324 ], "sequon_annotation_sites": [ { "start_pos": 1570, "end_pos": 1572 }, { "start_pos": 1762, "end_pos": 1764 }, { "start_pos": 1861, "end_pos": 1863 }, { "start_pos": 1953, "end_pos": 1955 }, { "start_pos": 2313, "end_pos": 2315 } ] }, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "o_linked_glycan_sites", "count": 3 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "o_linked_glycan_sites", "count": 3 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 33 }, { "field": "total_sites", "count": 33 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 18 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }