{ "uniprot_canonical_ac": "A2A5K6-1", "uniprot_ac": "A2A5K6", "uniprot_id": "ZN335_MOUSE", "mass": { "chemical_mass": 145603.0, "monoisotopic_mass": 145603.0 }, "refseq": { "ac": "NP_950192", "name": "zinc finger protein 335", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_950192" }, "gene_names": [ { "name": "Zfp335", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A2A5K6", "id": "A2A5K6" }, { "name": "Znf335", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A2A5K6", "id": "A2A5K6" }, { "name": "1810045J01Rik; NIF-1; Nif1; Znf335", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_950192", "id": "NP_950192" }, { "name": "Zfp335", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_950192", "id": "NP_950192" }, { "name": "Zfp335", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A2A5K6", "id": "A2A5K6" } ], "protein_names": [ { "name": "Zinc finger protein 335", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprotkb/A2A5K6/entry#names_and_taxonomy", "id": "A2A5K6" }, { "name": "NIF-1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A2A5K6/entry#names_and_taxonomy", "id": "A2A5K6" }, { "name": "NRC-interacting factor 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_950192", "id": "NP_950192" }, { "name": "NRC-interacting factor 1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A2A5K6/entry#names_and_taxonomy", "id": "A2A5K6" }, { "name": "zinc finger protein 335", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_950192", "id": "NP_950192" } ], "function": [ { "annotation": "Component or associated component of some histone methyltransferase complexes may regulate transcription through recruitment of those complexes on gene promoters (By similarity). Enhances ligand-dependent transcriptional activation by nuclear hormone receptors (By similarity). Plays an important role in neural progenitor cell proliferation and self-renewal through the regulation of specific genes involved brain development, including REST (PubMed:23178126). Also controls the expression of genes involved in somatic development and regulates, for instance, lymphoblast proliferation (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "A2A5K6", "url": "https://www.uniprot.org/uniprot/A2A5K6#function" }, { "database": "PubMed", "id": "23178126", "url": "https://glygen.org/publication/PubMed/23178126" }, { "database": "UniProtKB", "id": "Q9H4Z2", "url": "https://www.uniprot.org/uniprot/Q9H4Z2#function" } ] }, { "annotation": "P35 interacts with NIF-1 and regulates the subcellular localization of the protein independent of Cdk5-dependent phosphorylation. ...reveal a new mechanism of p35 in transcriptional regulation that does not require the kinase activity of Cdk5 Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_950192", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_950192" }, { "database": "PubMed", "id": "25329792", "url": "https://glygen.org/publication/PubMed/25329792" } ] }, { "annotation": "Results suggest that NIF-1 directs neuronal morphogenesis during early developmental stages through modulating activity-dependent gene transcription", "evidence": [ { "database": "RefSeq", "id": "NP_950192", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_950192" }, { "database": "PubMed", "id": "25573434", "url": "https://glygen.org/publication/PubMed/25573434" } ] }, { "annotation": "The Transcription Factor Zfp335 Promotes Differentiation and Persistence of Memory CD8(+) T Cells by Regulating TCF-1.", "evidence": [ { "database": "RefSeq", "id": "NP_950192", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_950192" }, { "database": "PubMed", "id": "35914836", "url": "https://glygen.org/publication/PubMed/35914836" } ] }, { "annotation": "Zfp335 establishes eTreg lineage and neonatal immune tolerance by targeting Hadha-mediated fatty acid oxidation. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_950192", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_950192" }, { "database": "PubMed", "id": "37843279", "url": "https://glygen.org/publication/PubMed/37843279" } ] }, { "annotation": "Zinc finger protein Zfp335 is required for the formation of the naive T cell compartment. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_950192", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_950192" }, { "database": "PubMed", "id": "25343476", "url": "https://glygen.org/publication/PubMed/25343476" } ] }, { "annotation": "Znf335 null mice are embryonically lethal, and conditional knockout leads to severely reduced cortical size.", "evidence": [ { "database": "RefSeq", "id": "NP_950192", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_950192" }, { "database": "PubMed", "id": "23178126", "url": "https://glygen.org/publication/PubMed/23178126" } ] } ], "disease": [ { "disease_id": "DOID:0070294", "recommended_name": { "id": "DOID:0070294", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0070294", "name": "primary autosomal recessive microcephaly 10", "description": "A primary autosomal recessive microcephaly that has_material_basis_in homozygous or compound heterozygous mutation in the ZNF335 gene on chromosome 20q13." }, "synonyms": [ { "id": "DOID:0070294", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0070294", "name": "MCPH10", "description": "" }, { "id": "MONDO:0014043", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014043", "name": "microcephalic primordial dwarfism due to ZNF335 deficiency", "description": "Microcephalic primordial dwarfism due to ZNF335 deficiency is characterized by severe antenatal microencephaly, simplified gyration, agenesis of the corpus callosum, absence of basal ganglia (very rare), pontocerebellar atrophy and involvement of the white matter with secondary cerebral atrophy. Congenital cataract, choanal atresia, multiple arthrogryposis and spastic tetraparesis can occur." }, { "id": "MONDO:0014043", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014043", "name": "microcephalic primordial dwarfism, Walsh type", "description": "" }, { "id": "MONDO:0014043", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014043", "name": "MCPH10", "description": "" }, { "id": "MONDO:0014043", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014043", "name": "microcephaly 10, primary, autosomal recessive", "description": "" }, { "id": "MONDO:0014043", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014043", "name": "primary autosomal recessive microcephaly 10", "description": "" }, { "id": "MIM:615095", "resource": "MIM", "url": "https://www.omim.org/entry/615095", "name": "Microcephaly 10, primary, autosomal recessive", "description": "Microcephaly 10, primary, autosomal recessive" } ], "evidence": [ { "id": "0070294", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0070294" } ] } ], "snv": [ { "evidence": [ { "id": "rs3388610477", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs3388610477" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 120, "end_pos": 120, "sequence_org": "D", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (DCT->NCT).", "chr_id": "2", "chr_pos": "164751207", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "D120", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs231938713", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs231938713" } ], "glycoeffect": [ "n-glyco-sequon-gain", "o-glyco-site-loss" ], "start_pos": 73, "end_pos": 73, "sequence_org": "S", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (SIS->NIS).", "chr_id": "2", "chr_pos": "164751347", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "S73", "keywords": [ "ebi", "germline" ] } ], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "A2A5K6", "url": "https://www.uniprot.org/uniprot/A2A5K6" } ], "common_name": "Mouse", "glygen_name": "Mouse", "reference_species": "Mus musculus [10090]" } ], "gene": [ { "name": "Znf335", "url": "https://www.uniprot.org/uniprot/A2A5K6", "locus": {} } ], "crossref": [ { "id": "ENSMUSG00000039834", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000039834", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "329559", "url": "https://www.ncbi.nlm.nih.gov/gene/329559", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "mmu:329559", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:329559", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "2682313", "url": "http://www.informatics.jax.org/marker/MGI:2682313", "database": "MGI", "categories": [ "Organism-specific" ] }, { "id": "A2A5K6", "url": "https://oglcnac.org/atlas/detail/A2A5K6", "database": "O-GlcNAc Atlas", "categories": [ "Glycoproteomics" ] }, { "id": "A2A5K6", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=A2A5K6", "database": "O-GlcNAc Database", "categories": [ "Glycoproteomics" ] }, { "id": "HKRAHVG", "url": "https://omabrowser.org/oma/group/HKRAHVG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "4239435at2759", "url": "http://www.orthodb.org/?query=4239435at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24403", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24403", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24403:SF36", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24403:SF36", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "http://pfam.xfam.org/family/PF00096", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF13909", "url": "http://pfam.xfam.org/family/PF13909", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF13912", "url": "http://pfam.xfam.org/family/PF13912", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_A2A5K6", "url": "http://purl.obolibrary.org/obo/PR_A2A5K6", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_950192", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_950192", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A2A5K6", "url": "https://www.uniprot.org/uniprot/A2A5K6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A2A5K6-1", "url": "https://www.uniprot.org/uniprot/A2A5K6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q6P5F4", "url": "https://www.uniprot.org/uniprot/Q6P5F4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q6P5F4-1", "url": "https://www.uniprot.org/uniprot/Q6P5F4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "S4R2J0", "url": "https://www.uniprot.org/uniprot/S4R2J0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "S4R2J0-1", "url": "https://www.uniprot.org/uniprot/S4R2J0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEENEVESSSDAAPRPGQPEEPSESGLGVCTSEAVSADSSDAATVPGLTEADDSGVGQSSDGGNHSVEEVSESISTDPLPHGCLPDSSSVSRGPVAEMPGGPPALVHSSVLPDPSMLVSDCTASSSDLGSAIDKIIESTIGPDLIQSCITVTSGEEGGAETTQYLILQGPDDGAPMASSMSTSTLANSLAAIEALADGPTSTSACLEPPEEPQGDPSSVAQQPPAPVTEELDLQSLEAMMEVVVVQQFKCKMCQYRSSTKATLLRHMRERHFRPALAAAAAATGKRGRVRKWGTSTKTTEEDRPEEEEEDDDIVDAGAIDDLEEDSDYNPAEDEPRGRQLRLQRPTPSTPRPRRRPGRPRKLPRLETSDLHDGVGQPLVSSQSTQSPPELQDLEAPSSSGLRALGKVGRGLVESGVSQSDAENAAPSCQDEADAPPRRRGRPSRRFLGKKYRKYYYKSPKPLLRPYLCRICGSRFLSHEDLRFHVNSHEAGDPQLFRCLQCSYRSRRWSSLKEHMFNHVGSKPYKCDECSYTSVYRKDVIRHAAVHSQDRKKRPDPTPKLSSFPCPVCGRVYPMQKRLTQHMKTHSTEKPHMCDKCGKSFKKRYTFKMHLLTHIQAVANRRFKCEFCEFVCEDKKALLNHQLSHVSDKPFKCSFCPYRTFREDFLLSHVAVKHTGAKPFACEYCHFSTRHKKNLRLHVRCRHANSFEEWGRRHPEEPPSRRRPFFSLQQIEELKQQHSTAPGPPLSSPGPEAPQEPAPFQSPETPPLLCPDALGGTTIIYQQGAEESTAVATQTALDLLLNMSAQRELGATALQVAVVKSEGIEAELTSTGGQPSPEDTTPRVVTLHMAESGSSVAAESQLGPSDLQQIALPSGPFGGASYSVITAPPVEGRTSASGPPYREEPPGEAAQAVVVSDTLKEAGTHYIMAADGTQLHHIELTADGSISFPSPDTLAPGTKWPLLQCGGPPRDGSEVLSPTKTHHMGGSQGSSTPPPAASHTLGLVVPQSPPSAAASSTKKFSCKVCSEAFPSRAEMESHKRAHAGPAAFKCPDCPFSARQWPEVRAHMAQHSSLRPHQCNQCSFASKNKKDLRRHMLTHTNEKPFSCHVCGQRFNRNGHLKFHIQRLHSIDGRKTGTSTARAPAQTIILNSEEETLATLHTAFQSSHGVLGTERLQQALSQEHIIVAQEQTVTNQEEATYIQEITADGQTVQHLVTSDNQVQYIISQDGVQHLLPQEYVVVPDGHHIQVQEGQITHIQYEQGTPFLQESQIQYVPVSPSQQLVTQAQLEAAAHSAVTAVADAAMAQAQGLFGTEEAVPEQIHQLQHQGIEYDVITLSDD", "length": 1337, "header": "sp|A2A5K6-1|ZN335_MOUSE Isoform 1 of Zinc finger protein 335 OS=Mus musculus OX=10090 GN=Znf335 PE=1 SV=1 CANONICAL=A2A5K6-1" }, "isoforms": [ { "isoform_ac": "A2A5K6-1", "url": "https://www.uniprot.org/uniprotkb/A2A5K6/entry#A2A5K6-1", "sequence": { "sequence": "MEENEVESSSDAAPRPGQPEEPSESGLGVCTSEAVSADSSDAATVPGLTEADDSGVGQSSDGGNHSVEEVSESISTDPLPHGCLPDSSSVSRGPVAEMPGGPPALVHSSVLPDPSMLVSDCTASSSDLGSAIDKIIESTIGPDLIQSCITVTSGEEGGAETTQYLILQGPDDGAPMASSMSTSTLANSLAAIEALADGPTSTSACLEPPEEPQGDPSSVAQQPPAPVTEELDLQSLEAMMEVVVVQQFKCKMCQYRSSTKATLLRHMRERHFRPALAAAAAATGKRGRVRKWGTSTKTTEEDRPEEEEEDDDIVDAGAIDDLEEDSDYNPAEDEPRGRQLRLQRPTPSTPRPRRRPGRPRKLPRLETSDLHDGVGQPLVSSQSTQSPPELQDLEAPSSSGLRALGKVGRGLVESGVSQSDAENAAPSCQDEADAPPRRRGRPSRRFLGKKYRKYYYKSPKPLLRPYLCRICGSRFLSHEDLRFHVNSHEAGDPQLFRCLQCSYRSRRWSSLKEHMFNHVGSKPYKCDECSYTSVYRKDVIRHAAVHSQDRKKRPDPTPKLSSFPCPVCGRVYPMQKRLTQHMKTHSTEKPHMCDKCGKSFKKRYTFKMHLLTHIQAVANRRFKCEFCEFVCEDKKALLNHQLSHVSDKPFKCSFCPYRTFREDFLLSHVAVKHTGAKPFACEYCHFSTRHKKNLRLHVRCRHANSFEEWGRRHPEEPPSRRRPFFSLQQIEELKQQHSTAPGPPLSSPGPEAPQEPAPFQSPETPPLLCPDALGGTTIIYQQGAEESTAVATQTALDLLLNMSAQRELGATALQVAVVKSEGIEAELTSTGGQPSPEDTTPRVVTLHMAESGSSVAAESQLGPSDLQQIALPSGPFGGASYSVITAPPVEGRTSASGPPYREEPPGEAAQAVVVSDTLKEAGTHYIMAADGTQLHHIELTADGSISFPSPDTLAPGTKWPLLQCGGPPRDGSEVLSPTKTHHMGGSQGSSTPPPAASHTLGLVVPQSPPSAAASSTKKFSCKVCSEAFPSRAEMESHKRAHAGPAAFKCPDCPFSARQWPEVRAHMAQHSSLRPHQCNQCSFASKNKKDLRRHMLTHTNEKPFSCHVCGQRFNRNGHLKFHIQRLHSIDGRKTGTSTARAPAQTIILNSEEETLATLHTAFQSSHGVLGTERLQQALSQEHIIVAQEQTVTNQEEATYIQEITADGQTVQHLVTSDNQVQYIISQDGVQHLLPQEYVVVPDGHHIQVQEGQITHIQYEQGTPFLQESQIQYVPVSPSQQLVTQAQLEAAAHSAVTAVADAAMAQAQGLFGTEEAVPEQIHQLQHQGIEYDVITLSDD", "length": 1337, "header": "sp|A2A5K6-1|ZN335_MOUSE Isoform 1 of Zinc finger protein 335 OS=Mus musculus OX=10090 GN=Znf335 PE=1 SV=1 CANONICAL=A2A5K6-1" }, "locus": { "chromosome": "2", "start_pos": 164752742, "end_pos": 164734087, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000041361.14", "url": "https://www.ensembl.org/id/ENSMUST00000041361.14" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000038298.8", "url": "https://www.ensembl.org/id/ENSMUSP00000038298.8" } ] } }, { "isoform_ac": "Q6P5F4-1", "url": "https://www.uniprot.org/uniprotkb/A2A5K6/entry#Q6P5F4-1", "sequence": { "sequence": "MEENEVESSSDAAPRPGQPEEPSESGLGVCTSEAVSADSSDAATVPGLTEADDSGVGQSSDGGNHSVEEVSESISTDPLPHGCLPDSSSVSRGPVAEMPGGPPALVHSSVLPDPSMLVSDCTASSSDLGSAIDKIIESTIGPDLIQSCITVTSGEEGGAETTQYLILQGPDDGAPMASSMSTSTLANSLAAIEALADGPTSTSACLEPPEEPQGDPSSVAQQPPAPVTEELDLQSLEAMMEVVVVQQFKCKMCQYRSSTKATLLRHMRERHFRPALAAAAAATGKRGRVRKWGTSTKTTEEDRPEEEEEDDDIVDAGAIDDLEEDSDYNPAEDEPRGRQLRLQRPTPSTPRPRRRPGRPRKLPRLETSDLHDGVGQPLVSSQSTQSPPELQDLEAPSSSGLRALGKVGRGLVESGVSQSDAENAAPSCQDEADAPPRRRGRPSRRFLGKKYRKYYYKSPKPLLRPYLCRICGSRFLSHEDLRFHVNSHEAGDPQLFRCLQCSYRSRRWSSLKEHMFNHVGSKPYKCDECSYTSVYRKDVIRHAAVHSQDRKKRPDPTPKLSSFPCPVCGRVYPMQKRLTQHMKTHSTEKPHMCDKIQV", "length": 598, "header": "tr|Q6P5F4-1|ZN335_MOUSE Computationally mapped isoform of Zinc finger protein 335 OS=Mus musculus OX=10090 GN=Znf335 PE=1 SV=1 CANONICAL=A2A5K6-1" }, "locus": { "chromosome": "2", "start_pos": 164752742, "end_pos": 164741943, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000183830.8", "url": "https://www.ensembl.org/id/ENSMUST00000183830.8" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000139133.2", "url": "https://www.ensembl.org/id/ENSMUSP00000139133.2" } ] } }, { "isoform_ac": "S4R2J0-1", "url": "https://www.uniprot.org/uniprotkb/A2A5K6/entry#S4R2J0-1", "sequence": { "sequence": "HFRPALAAAAAATGKRGRVRKWGTSTKTTEEDRPEEEEEDDDIVDAGAIDDLEGTLLCFSLVLGLRCHALLLDMGSGRLNSDSHAPQQILH", "length": 91, "header": "tr|S4R2J0-1|ZN335_MOUSE Computationally mapped isoform of Zinc finger protein 335 OS=Mus musculus OX=10090 GN=Znf335 PE=1 SV=1 CANONICAL=A2A5K6-1" }, "locus": { "chromosome": "2", "start_pos": 164749585, "end_pos": 164748303, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000139247.2", "url": "https://www.ensembl.org/id/ENSMUST00000139247.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000138664.2", "url": "https://www.ensembl.org/id/ENSMUSP00000138664.2" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 510, "start_aa": "Ser", "end_pos": 510, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser510", "evidence": [ { "id": "30059200", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30059200" }, { "id": "A2A5K6", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=A2A5K6" }, { "id": "A2A5K6", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/A2A5K6" } ] } ], "phosphorylation": [ { "start_pos": 1007, "end_pos": 1007, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A2A5K6", "url": "https://www.uniprot.org/uniprot/A2A5K6" } ], "site_lbl": "Ser1007" }, { "start_pos": 1127, "end_pos": 1127, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "A2A5K6", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2A5K6" } ], "site_lbl": "Ser1127" }, { "start_pos": 1149, "end_pos": 1149, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A2A5K6", "url": "https://www.uniprot.org/uniprot/A2A5K6" } ], "site_lbl": "Ser1149" }, { "start_pos": 976, "end_pos": 976, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A2A5K6", "url": "https://www.uniprot.org/uniprot/A2A5K6" }, { "database": "iPTMnet", "id": "A2A5K6", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2A5K6" } ], "site_lbl": "Ser976" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "Microcephaly gene links trithorax and REST/NRSF to control neural stem cell proliferation and differentiation.", "journal": "Cell", "date": "2012", "authors": "Yang YJ, Baltus AE, Mathew RS, Murphy EA, Evrony GD, Gonzalez DM, Wang EP, Marshall-Walker CA, Barry BJ, Murn J, Tatarakis A, Mahajan MA, Samuels HH, Shi Y, Golden JA, Mahajnah M, Shenhav R, Walsh CA", "evidence": [ { "database": "UniProtKB", "id": "A2A5K6", "url": "https://www.uniprot.org/uniprot/A2A5K6" }, { "database": "RefSeq", "id": "NP_950192", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_950192" } ], "reference": [ { "type": "PubMed", "id": "23178126", "url": "https://glygen.org/publication/PubMed/23178126" } ] }, { "title": "p35 regulates the CRM1-dependent nucleocytoplasmic shuttling of nuclear hormone receptor coregulator-interacting factor 1 (NIF-1).", "journal": "PloS one", "date": "2014", "authors": "Zhao XS, Fu WY, Chien WW, Li Z, Fu AK, Ip NY", "evidence": [ { "database": "RefSeq", "id": "NP_950192", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_950192" } ], "reference": [ { "type": "PubMed", "id": "25329792", "url": "https://glygen.org/publication/PubMed/25329792" } ] }, { "title": "Zinc finger protein Zfp335 is required for the formation of the naive T cell compartment.", "journal": "eLife", "date": "2014", "authors": "Han BY, Wu S, Foo CS, Horton RM, Jenne CN, Watson SR, Whittle B, Goodnow CC, Cyster JG", "evidence": [ { "database": "RefSeq", "id": "NP_950192", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_950192" } ], "reference": [ { "type": "PubMed", "id": "25343476", "url": "https://glygen.org/publication/PubMed/25343476" } ] }, { "title": "NRC-interacting factor directs neurite outgrowth in an activity-dependent manner.", "journal": "Neuroscience", "date": "2015", "authors": "Zhao XS, Fu WY, Hung KW, Chien WW, Li Z, Fu AK, Ip NY", "evidence": [ { "database": "RefSeq", "id": "NP_950192", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_950192" } ], "reference": [ { "type": "PubMed", "id": "25573434", "url": "https://glygen.org/publication/PubMed/25573434" } ] }, { "title": "Quantitative Profiling of Protein O-GlcNAcylation Sites by an Isotope-Tagged Cleavable Linker.", "journal": "ACS chemical biology", "date": "2018", "authors": "Qin K, Zhu Y, Qin W, Gao J, Shao X, Wang YL, Zhou W, Wang C, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "A2A5K6", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=A2A5K6" }, { "database": "O-GlcNAc Atlas", "id": "A2A5K6", "url": "https://oglcnac.org/atlas/detail/A2A5K6" } ], "reference": [ { "type": "PubMed", "id": "30059200", "url": "https://glygen.org/publication/PubMed/30059200" } ] }, { "title": "The Transcription Factor Zfp335 Promotes Differentiation and Persistence of Memory CD8(+) T Cells by Regulating TCF-1.", "journal": "Journal of immunology (Baltimore, Md. : 1950)", "date": "2022", "authors": "Liu H, Wang X, Ding R, Jiao A, Zheng H, Zhang C, Feng Z, Su Y, Yang X, Lei L, Sun L, Zhang L, Sun C, Zhang B", "evidence": [ { "database": "RefSeq", "id": "NP_950192", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_950192" } ], "reference": [ { "type": "PubMed", "id": "35914836", "url": "https://glygen.org/publication/PubMed/35914836" } ] }, { "title": "Zfp335 establishes eTreg lineage and neonatal immune tolerance by targeting Hadha-mediated fatty acid oxidation.", "journal": "The Journal of clinical investigation", "date": "2023-10-16", "authors": "Wang Xin, Sun Lina, Yang Biao, Li Wenhua, Zhang Cangang, Yang Xiaofeng, Sun Yae, Shen Xiaonan, Gao Yang, Ju Bomiao, Gao Yafeng, Liu Dan, Song Jiapeng, Jia Xiaoxuan, Su Yanhong, Jiao Anjun, Liu Haiyan, Zhang Lianjun, He Lan, Lei Lei, Chen WanJun, Zhang Baojun", "evidence": [ { "database": "RefSeq", "id": "NP_950192", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_950192" } ], "reference": [ { "type": "PubMed", "id": "37843279", "url": "https://glygen.org/publication/PubMed/37843279" } ] } ], "pathway": [ { "id": "mmu:329559", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:329559", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "G3V893-1", "protein_name": "Zinc finger protein 335", "gene_name": "Znf335", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": 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"length": 1342 }, "evidence": [ { "id": "46370658", "url": "http://www.informatics.jax.org/homology/46370658", "database": "MGI" }, { "id": "A2A5K6", "url": "https://omabrowser.org/oma/group/A2A5K6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 12, "go_terms": [ { "name": "in utero embryonic development", "id": "GO:0001701", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001701", "evidence": [ { "database": "UniProtKB", "id": "A2A5K6", "url": "https://www.uniprot.org/uniprot/A2A5K6" } ], "pmid": "" }, { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "A2A5K6", "url": "https://www.uniprot.org/uniprot/A2A5K6" } ], "pmid": "" }, { "name": "neuron projection morphogenesis", "id": "GO:0048812", "url": 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"id": "GO:0035097", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035097", "evidence": [ { "database": "UniProtKB", "id": "A2A5K6", "url": "https://www.uniprot.org/uniprot/A2A5K6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "A2A5K6", "url": "https://www.uniprot.org/uniprot/A2A5K6" } ], "pmid": "" }, { "name": "transcription cis-regulatory region binding", "id": "GO:0000976", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000976", "evidence": [ { "database": "UniProtKB", "id": "A2A5K6", "url": "https://www.uniprot.org/uniprot/A2A5K6" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "A2A5K6", "url": 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