{ "uniprot_canonical_ac": "A1Z910-1", "uniprot_ac": "A1Z910", "uniprot_id": "A1Z910_DROME", "mass": { "chemical_mass": 73797.0, "monoisotopic_mass": 73797.0 }, "refseq": { "ac": "NP_610787", "name": "Neprilysin-like 10", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_610787" }, "gene_names": [ { "name": "Nepl10", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A1Z910", "id": "A1Z910" }, { "name": "CG8550; Dmel\\CG8550", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_610787", "id": "NP_610787" }, { "name": "CG8550", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A1Z910", "id": "A1Z910" }, { "name": "Dmel\\CG8550", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A1Z910", "id": "A1Z910" }, { "name": "Dmel_CG8550", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A1Z910", "id": "A1Z910" }, { "name": "Nepl10", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_610787", "id": "NP_610787" } ], "protein_names": [ { "name": "3.4.24.-", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A1Z910/entry#names_and_taxonomy", "id": "A1Z910" }, { "name": "CG8550-PA; Nepl10-PA", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_610787", "id": "NP_610787" }, { "name": "Neprilysin-like 10", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_610787", "id": "NP_610787" }, { "name": "Neprilysin-like 10", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A1Z910/entry#names_and_taxonomy", "id": "A1Z910" } ], "function": [], "disease": [ { "disease_id": "DOID:0050646", "recommended_name": { "id": "DOID:0050646", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050646", "name": "distal arthrogryposis", "description": "A muscle tissue disease characterized by congenital joint contractures of hand and feet." }, "synonyms": [ { "id": "DOID:0050646", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050646", "name": "Arthrogryposis Multiplex Congenita", "description": "" }, { "id": "MONDO:0007157", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007157", "name": "arthrogryposis, distal, type 1A", "description": "" }, { "id": "MONDO:0007157", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007157", "name": "arthrogryposis multiplex congenita", "description": "" }, { "id": "MONDO:0007157", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007157", "name": "AMC", "description": "" }, { "id": "MONDO:0007157", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007157", "name": "DA1A", "description": "" }, { "id": "MONDO:0007157", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007157", "name": "arthrogryposis, distal, type 1A", "description": "" }, { "id": "MONDO:0007157", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007157", "name": "arthrogryposis multiplex congenita, distal, type 1", "description": "" }, { "id": "MONDO:0007157", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007157", "name": "arthrogryposis, distal, type 1", "description": "" }, { "id": "MONDO:0007157", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007157", "name": "arthrogryposis, distal, type 2B4", "description": "" }, { "id": "MIM:108120", "resource": "MIM", "url": "https://www.omim.org/entry/108120", "name": "Arthrogryposis, distal, 1A", "description": "Arthrogryposis, distal, 1A" } ], "evidence": [ { "id": "0050646", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0050646" } ] }, { "disease_id": "DOID:0111594", "recommended_name": { "id": "DOID:0111594", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111594", "name": "distal arthrogryposis type 5D", "description": "A distal arthrogryposis characterized by severe camptodactyly of the hands, mild camptodactyly of the toes, extension contractures of the knee, and distinctive facial features that has_material_basis_in homozygous or compound heterozygous mutation in the ECEL1 gene on chromosome 2q37.1." }, "synonyms": [ { "id": "DOID:0111594", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111594", "name": "distal arthrogryposis type 5 without ophthalmoparesis", "description": "" }, { "id": "DOID:0111594", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111594", "name": "DA5D", "description": "" }, { "id": "DOID:0111594", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111594", "name": "distal arthrogryposis type 5 without ophthalmoplegia", "description": "" }, { "id": "MONDO:0014028", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014028", "name": "distal arthrogryposis type 5D", "description": "Distal arthrogryposis type 5D is a rare subtype of distal arthrogryposis syndrome characterized by arthrogryposis multiplex congenita affecting the hands, feet, ankle, shoulders and/or neck, with camptodactyly of the fingers and limited knee and hip extension, associated with asymmetric ptosis and, less frequently, other ocular manifestations (e.g. ophthalmoplegia, strabismus). Affected individuals frequently have a bulbous nose, furrowed tongue, micro/retrognathia, a short neck, congenital hip dislocation, club feet, scoliosis and short stature." }, { "id": "MONDO:0014028", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014028", "name": "DA5D", "description": "" }, { "id": "MONDO:0014028", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014028", "name": "ECEL1 distal arthrogryposis", "description": "" }, { "id": "MONDO:0014028", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014028", "name": "distal arthrogryposis caused by mutation in ECEL1", "description": "" }, { "id": "MONDO:0014028", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014028", "name": "distal arthrogryposis type 5 without ophthalmoparesis", "description": "" }, { "id": "MONDO:0014028", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014028", "name": "distal arthrogryposis type 5 without ophthalmoplegia", "description": "" }, { "id": "MONDO:0014028", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014028", "name": "arthrogryposis, distal, type 5D", "description": "" }, { "id": "MIM:615065", "resource": "MIM", "url": "https://www.omim.org/entry/615065", "name": "Arthrogryposis, distal, 5D", "description": "Arthrogryposis, distal, 5D" } ], "evidence": [ { "id": "0111594", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0111594" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "A1Z910", "url": "https://www.uniprot.org/uniprot/A1Z910" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "gene": [ { "name": "Nepl10", "url": "https://www.uniprot.org/uniprot/A1Z910", "locus": { "chromosome": "2R", "start_pos": 12474021, "end_pos": 12471915, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "FBgn0033742", "url": "https://www.ensembl.org/id/FBgn0033742" } ] } } ], "crossref": [ { "id": "FBgn0033742", "url": "https://bgee.org/?page=gene&gene_id=FBgn0033742", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "FBgn0033742", "url": "https://flybase.org/reports/FBgn0033742", "database": "FlyBase", "categories": [ "Organism-specific" ] }, { "id": "36366", "url": "https://www.ncbi.nlm.nih.gov/gene/36366", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000718", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000718", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018497", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018497", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024079", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024079", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042089", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042089", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "dme:Dmel_CG8550", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+dme:Dmel_CG8550", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "RDDERVN", "url": "https://omabrowser.org/oma/group/RDDERVN/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "3599368at2759", "url": "http://www.orthodb.org/?query=3599368at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11733", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11733", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11733:SF167", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11733:SF167", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01431", "url": "http://pfam.xfam.org/family/PF01431", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "R-DME-2022377", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-2022377", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-DME-5578768", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-5578768", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-DME-6798695", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-6798695", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_610787", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_610787", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A1Z910", "url": "https://www.uniprot.org/uniprot/A1Z910", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A1Z910-1", "url": "https://www.uniprot.org/uniprot/A1Z910-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGCLLLLCSCLVALFIPIQAIVDINVATSNDIHNNLNRTTSPCTNFWNFACGRFSSASKYVDNFERVEDQFATAMVEFMESHLGENDTLAPRLIKQMRQYYKACKEDTRKLHGNPRPEELVNQWILHPKKFLVYGLNGVFIDERVDVAANDSMRWVIQLRMPDPADRYSDRRVLQLMRLYEEAWYSMGVVKLVEKMHQLQDKYRAEYPVVYTWSFSELRQEIPIPHSFFIELLGVNHTEELYHLTFEVSDVEYLRECFRCLRDFASEPKDTYIRARQYVLVEESEPRERNPRSCIHHMRAYLPLGMNYIYDRFIYQNREEDTSKVLEILSTLKAAFGQYLDANRLQLTPNQLAYVRAKLEGIQIKIGNLPEEKSPEFYNNHYGSANFSATNFLANLLEAFALRTRLQNAGLLARNSRVDLRHYYVNDNVRKARTSPFYENERNTITVPMEFLQWPLFDHREHTIFQHSLLGAVLGHEMNHAFEQEGILFDAAGNESPVGLEIRESKPFRDAIKCAEEQPFVSLKERLADLNGLQLAYDAFFGLAHDSRQFEYRPYAFEQEFTAPQLFHLSYAQFFCGSLPPVIAHDRDDERVNVSVGNLRQFAYDFNCETSPSSVCEMWRPGDVANSNRNVHP", "length": 633, "header": "tr|A1Z910-1|A1Z910_DROME Isoform 1 of Neprilysin-like 10 OS=Drosophila melanogaster OX=7227 GN=Nepl10 PE=4 SV=1 CANONICAL=A1Z910-1" }, "isoforms": [ { "isoform_ac": "A1Z910-1", "url": "https://www.uniprot.org/uniprotkb/A1Z910/entry#A1Z910-1", "sequence": { "sequence": "MGCLLLLCSCLVALFIPIQAIVDINVATSNDIHNNLNRTTSPCTNFWNFACGRFSSASKYVDNFERVEDQFATAMVEFMESHLGENDTLAPRLIKQMRQYYKACKEDTRKLHGNPRPEELVNQWILHPKKFLVYGLNGVFIDERVDVAANDSMRWVIQLRMPDPADRYSDRRVLQLMRLYEEAWYSMGVVKLVEKMHQLQDKYRAEYPVVYTWSFSELRQEIPIPHSFFIELLGVNHTEELYHLTFEVSDVEYLRECFRCLRDFASEPKDTYIRARQYVLVEESEPRERNPRSCIHHMRAYLPLGMNYIYDRFIYQNREEDTSKVLEILSTLKAAFGQYLDANRLQLTPNQLAYVRAKLEGIQIKIGNLPEEKSPEFYNNHYGSANFSATNFLANLLEAFALRTRLQNAGLLARNSRVDLRHYYVNDNVRKARTSPFYENERNTITVPMEFLQWPLFDHREHTIFQHSLLGAVLGHEMNHAFEQEGILFDAAGNESPVGLEIRESKPFRDAIKCAEEQPFVSLKERLADLNGLQLAYDAFFGLAHDSRQFEYRPYAFEQEFTAPQLFHLSYAQFFCGSLPPVIAHDRDDERVNVSVGNLRQFAYDFNCETSPSSVCEMWRPGDVANSNRNVHP", "length": 633, "header": "tr|A1Z910-1|A1Z910_DROME Isoform 1 of Neprilysin-like 10 OS=Drosophila melanogaster OX=7227 GN=Nepl10 PE=4 SV=1 CANONICAL=A1Z910-1" }, "locus": { "chromosome": "2R", "start_pos": 12473813, "end_pos": 12471915, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "FBtr0087935", "url": "https://www.ensembl.org/id/FBtr0087935" }, { "database": "Ensembl Peptide", "id": "FBpp0087046", "url": "https://www.ensembl.org/id/FBpp0087046" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "The genome sequence of Drosophila melanogaster.", "journal": "Science", "date": "2000", "authors": "Adams MD, Celniker SE, Holt RA, Evans CA, Gocayne JD, Amanatides PG, Scherer SE, Li PW, Hoskins RA, Galle RF, George RA, Lewis SE, Richards S, Ashburner M, Henderson SN, Sutton GG, Wortman JR, Yandell MD, Zhang Q, Chen LX, Brandon RC, Rogers YH, Blazej RG, Champe M, Pfeiffer BD, Wan KH, Doyle C, Baxter EG, Helt G, Nelson CR, Gabor GL, Abril JF, Agbayani A, An HJ, Andrews-Pfannkoch C, Baldwin D, Ballew RM, Basu A, Baxendale J, Bayraktaroglu L, Beasley EM, Beeson KY, Benos PV, Berman BP, Bhandari D, Bolshakov S, Borkova D, Botchan MR, Bouck J, Brokstein P, Brottier P, Burtis KC, Busam DA, Butler H, Cadieu E, Center A, Chandra I, Cherry JM, Cawley S, Dahlke C, Davenport LB, Davies P, de Pablos B, Delcher A, Deng Z, Mays AD, Dew I, Dietz SM, Dodson K, Doup LE, Downes M, Dugan-Rocha S, Dunkov BC, Dunn P, Durbin KJ, Evangelista CC, Ferraz C, Ferriera S, Fleischmann W, Fosler C, Gabrielian AE, Garg NS, Gelbart WM, Glasser K, Glodek A, Gong F, Gorrell JH, Gu Z, Guan P, Harris M, Harris NL, Harvey D, Heiman TJ, Hernandez JR, Houck J, Hostin D, Houston KA, Howland TJ, Wei MH, Ibegwam C, Jalali M, Kalush F, Karpen GH, Ke Z, Kennison JA, Ketchum KA, Kimmel BE, Kodira CD, Kraft C, Kravitz S, Kulp D, Lai Z, Lasko P, Lei Y, Levitsky AA, Li J, Li Z, Liang Y, Lin X, Liu X, Mattei B, McIntosh TC, McLeod MP, McPherson D, Merkulov G, Milshina NV, Mobarry C, Morris J, Moshrefi A, Mount SM, Moy M, Murphy B, Murphy L, Muzny DM, Nelson DL, Nelson DR, Nelson KA, Nixon K, Nusskern DR, Pacleb JM, Palazzolo M, Pittman GS, Pan S, Pollard J, Puri V, Reese MG, Reinert K, Remington K, Saunders RD, Scheeler F, Shen H, Shue BC, Siden-Kiamos I, Simpson M, Skupski MP, Smith T, Spier E, Spradling AC, Stapleton M, Strong R, Sun E, Svirskas R, Tector C, Turner R, Venter E, Wang AH, Wang X, Wang ZY, Wassarman DA, Weinstock GM, Weissenbach J, Williams SM, WoodageT, Worley KC, Wu D, Yang S, Yao QA, Ye J, Yeh RF, Zaveri JS, Zhan M, Zhang G, Zhao Q, Zheng L, Zheng XH, Zhong FN, Zhong W, Zhou X, Zhu S, Zhu X, Smith HO, Gibbs RA, Myers EW, Rubin GM, Venter JC", "evidence": [ { "database": "UniProtKB", "id": "A1Z910", "url": "https://www.uniprot.org/uniprot/A1Z910" } ], "reference": [ { "type": "PubMed", "id": "10731132", "url": "https://glygen.org/publication/PubMed/10731132" } ] }, { "title": "Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence.", "journal": "Genome Biol.", "date": "2002", "authors": "Celniker SE, Wheeler DA, Kronmiller B, Carlson JW, Halpern A, Patel S, Adams M, Champe M, Dugan SP, Frise E, Hodgson A, George RA, Hoskins RA, Laverty T, Muzny DM, Nelson CR, Pacleb JM, Park S, Pfeiffer BD, Richards S, Sodergren EJ, Svirskas R, Tabor PE, Wan K, Stapleton M, Sutton GG, Venter C, Weinstock G, Scherer SE, Myers EW, Gibbs RA, Rubin GM", "evidence": [ { "database": "UniProtKB", "id": "A1Z910", "url": "https://www.uniprot.org/uniprot/A1Z910" } ], "reference": [ { "type": "PubMed", "id": "12537568", "url": "https://glygen.org/publication/PubMed/12537568" } ] }, { "title": "Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.", "journal": "Genome Biol.", "date": "2002", "authors": "Misra S, Crosby MA, Mungall CJ, Matthews BB, Campbell KS, Hradecky P, Huang Y, Kaminker JS, Millburn GH, Prochnik SE, Smith CD, Tupy JL, Whitfied EJ, Bayraktaroglu L, Berman BP, Bettencourt BR, Celniker SE, de Grey AD, Drysdale RA, Harris NL, Richter J, Russo S, Schroeder AJ, Shu SQ, Stapleton M, Yamada C, Ashburner M, Gelbart WM, Rubin GM, Lewis SE", "evidence": [ { "database": "UniProtKB", "id": "A1Z910", "url": "https://www.uniprot.org/uniprot/A1Z910" } ], "reference": [ { "type": "PubMed", "id": "12537572", "url": "https://glygen.org/publication/PubMed/12537572" } ] }, { "title": "The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective.", "journal": "Genome Biol.", "date": "2002", "authors": "Kaminker JS, Bergman CM, Kronmiller B, Carlson J, Svirskas R, Patel S, Frise E, Wheeler DA, Lewis SE, Rubin GM, Ashburner M, Celniker SE", "evidence": [ { "database": "UniProtKB", "id": "A1Z910", "url": "https://www.uniprot.org/uniprot/A1Z910" } ], "reference": [ { "type": "PubMed", "id": "12537573", "url": "https://glygen.org/publication/PubMed/12537573" } ] }, { "title": "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly.", "journal": "Genome Biol.", "date": "2002", "authors": "Hoskins RA, Smith CD, Carlson JW, Carvalho AB, Halpern A, Kaminker JS, Kennedy C, Mungall CJ, Sullivan BA, Sutton GG, Yasuhara JC, Wakimoto BT, Myers EW, Celniker SE, Rubin GM, Karpen GH", "evidence": [ { "database": "UniProtKB", "id": "A1Z910", "url": "https://www.uniprot.org/uniprot/A1Z910" } ], "reference": [ { "type": "PubMed", "id": "12537574", "url": "https://glygen.org/publication/PubMed/12537574" } ] }, { "title": "Combined evidence annotation of transposable elements in genome sequences.", "journal": "PLoS Comput. Biol.", "date": "2005", "authors": "Quesneville H, Bergman CM, Andrieu O, Autard D, Nouaud D, Ashburner M, Anxolabehere D", "evidence": [ { "database": "UniProtKB", "id": "A1Z910", "url": "https://www.uniprot.org/uniprot/A1Z910" } ], "reference": [ { "type": "PubMed", "id": "16110336", "url": "https://glygen.org/publication/PubMed/16110336" } ] }, { "title": "The Release 5.1 annotation of Drosophila melanogaster heterochromatin.", "journal": "Science", "date": "2007", "authors": "Smith CD, Shu S, Mungall CJ, Karpen GH", "evidence": [ { "database": "UniProtKB", "id": "A1Z910", "url": "https://www.uniprot.org/uniprot/A1Z910" } ], "reference": [ { "type": "PubMed", "id": "17569856", "url": "https://glygen.org/publication/PubMed/17569856" } ] }, { "title": "Sequence finishing and mapping of Drosophila melanogaster heterochromatin.", "journal": "Science", "date": "2007", "authors": "Hoskins RA, Carlson JW, Kennedy C, Acevedo D, Evans-Holm M, Frise E, Wan KH, Park S, Mendez-Lago M, Rossi F, Villasante A, Dimitri P, Karpen GH, Celniker SE", "evidence": [ { "database": "UniProtKB", "id": "A1Z910", "url": "https://www.uniprot.org/uniprot/A1Z910" } ], "reference": [ { "type": "PubMed", "id": "17569867", "url": "https://glygen.org/publication/PubMed/17569867" } ] } ], "pathway": [ { "id": "dme:Dmel_CG8550", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+dme:Dmel_CG8550", "resource": "KEGG Pathway" }, { "id": "R-DME-2022377", "name": "Metabolism of Angiotensinogen to Angiotensins", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-2022377", "resource": "Reactome", "description": "Metabolism of Angiotensinogen to Angiotensins" }, { "id": "R-DME-5578768", "name": "Physiological factors", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-5578768", "resource": "Reactome", "description": "Physiological factors" }, { "id": "R-DME-6798695", "name": "Neutrophil degranulation", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-6798695", "resource": "Reactome", "description": "Neutrophil degranulation" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A1Z910", "url": "https://www.uniprot.org/uniprot/A1Z910" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "proteolysis", "id": "GO:0006508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006508", "evidence": [ { "database": "UniProtKB", "id": "A1Z910", "url": "https://www.uniprot.org/uniprot/A1Z910" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "hydrolase activity", "id": "GO:0016787", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016787", "evidence": [ { "database": "UniProtKB", "id": "A1Z910", "url": "https://www.uniprot.org/uniprot/A1Z910" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 150, "end_pos": 152, "annotation": "n_glycosylation_sequon" }, { "start_pos": 236, "end_pos": 238, "annotation": "n_glycosylation_sequon" }, { "start_pos": 37, "end_pos": 39, "annotation": "n_glycosylation_sequon" }, { "start_pos": 386, "end_pos": 388, "annotation": "n_glycosylation_sequon" }, { "start_pos": 494, "end_pos": 496, "annotation": "n_glycosylation_sequon" }, { "start_pos": 593, "end_pos": 595, "annotation": "n_glycosylation_sequon" }, { "start_pos": 86, "end_pos": 88, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "R-DME-2022368", "name": "MME:Zn2+ (Neprilysin) hydrolyses AGT(34-42)", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q9VN01-1", "Q9VYJ1-1", "Q8T062-1", "Q9W436-1", "Q9W5Y0-1", "Q8IMQ2-1", "Q9VAS0-1", "Q9VAS1-1", "Q9VCU3-1", "Q9Y136-1", "A1Z910-1", "Q9VAS2-1", "Q9VAY0-1", "Q9VAS4-1", "Q9VBX6-1", "Q9VCU1-1", "Q9W4B8-1", "Q9VH96-1", "A0A0B4K692-1", "Q9VCU2-1" ], "evidence": [ { "id": "R-DME-2022368", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-2022368" } ] }, { "id": "R-DME-2022396", "name": "MME:Zn2+ (Neprilysin) hydrolyses AGT(34-43)", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q9VN01-1", "Q9VYJ1-1", "Q8T062-1", "Q9W436-1", "Q9W5Y0-1", "Q8IMQ2-1", "Q9VAS0-1", "Q9VAS1-1", "Q9VCU3-1", "Q9Y136-1", "A1Z910-1", "Q9VAS2-1", "Q9VAY0-1", "Q9VAS4-1", "Q9VBX6-1", "Q9VCU1-1", "Q9W4B8-1", "Q9VH96-1", "A0A0B4K692-1", "Q9VCU2-1" ], "evidence": [ { "id": "R-DME-2022396", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-2022396" } ] }, { "id": "R-DME-6798743", "name": "Exocytosis of secretory granule membrane proteins", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "plasma membrane, secretory granule membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q9VN01-1", "Q9VYJ1-1", "X2JG15-1", "A1ZAB3-1", "P16621-1", "Q8T062-1", "Q9W436-1", "Q9W5Y0-1", "Q7KRW4-1", "Q8IMQ2-1", "Q9VAS0-1", "Q9VAS1-1", "Q9VCU3-1", "Q7KN92-1", "Q9V3I2-1", "Q9Y136-1", "A1Z910-1", "Q9VAS2-1", "Q9VAY0-1", "Q9VAS4-1", "Q9VBX6-1", "Q9VCU1-1", "Q9W4B8-1", "Q9VH96-1", "A0A0B4K692-1", "O76742-1", "Q9VAQ8-1", "Q9VCU2-1" ], "evidence": [ { "id": "R-DME-6798743", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-6798743" } ] }, { "id": "R-DME-9727607", "name": "MME:Zn2+ binds sacubitrilat", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. 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