{
    "uniprot_canonical_ac": "A1IIE5-1",
    "uniprot_ac": "A1IIE5",
    "uniprot_id": "A1IIE5_CHICK",
    "mass": {
        "chemical_mass": 12399.0,
        "monoisotopic_mass": 12399.0
    },
    "refseq": {
        "ac": "NP_001075177",
        "name": "transcription initiation factor IIA subunit 2",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001075177"
    },
    "gene_names": [
        {
            "name": "GTF2A2",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/A1IIE5",
            "id": "A1IIE5"
        },
        {
            "name": "GTF2A2",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001075177",
            "id": "NP_001075177"
        }
    ],
    "protein_names": [
        {
            "name": "Transcription initiation factor IIA subunit 2",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprotkb/A1IIE5/entry#names_and_taxonomy",
            "id": "A1IIE5"
        },
        {
            "name": "general transcription facter IIA subunit 2; general transcription factor IIA, 2, 12kDa; general transcription factor IIA 2",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001075177",
            "id": "NP_001075177"
        },
        {
            "name": "transcription initiation factor IIA subunit 2",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001075177",
            "id": "NP_001075177"
        }
    ],
    "function": [
        {
            "annotation": "TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A1IIE5",
                    "url": "https://www.uniprot.org/uniprot/A1IIE5#function"
                },
                {
                    "database": "UniProtKB",
                    "id": "PIRNR009415",
                    "url": "https://www.uniprot.org/uniprot/PIRNR009415#function"
                }
            ]
        }
    ],
    "disease": [],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Gallus gallus",
            "taxid": 9031,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A1IIE5",
                    "url": "https://www.uniprot.org/uniprot/A1IIE5"
                }
            ],
            "common_name": "Chicken",
            "glygen_name": "Chicken",
            "reference_species": "Gallus gallus [9031]"
        }
    ],
    "gene": [
        {
            "name": "GTF2A2",
            "url": "https://www.uniprot.org/uniprot/A1IIE5",
            "locus": {
                "chromosome": "10",
                "start_pos": 5420805,
                "end_pos": 5412881,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSGALG00010024716",
                        "url": "https://www.ensembl.org/id/ENSGALG00010024716"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSGALG00000003793",
            "url": "https://bgee.org/?page=gene&gene_id=ENSGALG00000003793",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "cd10014",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd10014",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "cd10145",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd10145",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "770910",
            "url": "https://www.ncbi.nlm.nih.gov/gene/770910",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "IPR003194",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR003194",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR009083",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR009083",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR009088",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR009088",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR015871",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR015871",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR015872",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR015872",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "gga:770910",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+gga:770910",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "QYYELYR",
            "url": "https://omabrowser.org/oma/group/QYYELYR/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "5052738at2759",
            "url": "http://www.orthodb.org/?query=5052738at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR10966",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10966",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR10966:SF0",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10966:SF0",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF02268",
            "url": "http://pfam.xfam.org/family/PF02268",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF02751",
            "url": "http://pfam.xfam.org/family/PF02751",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-GGA-674695",
            "url": "https://www.reactome.org/PathwayBrowser/#R-GGA-674695",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-GGA-6807505",
            "url": "https://www.reactome.org/PathwayBrowser/#R-GGA-6807505",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-GGA-73776",
            "url": "https://www.reactome.org/PathwayBrowser/#R-GGA-73776",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-GGA-73779",
            "url": "https://www.reactome.org/PathwayBrowser/#R-GGA-73779",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-GGA-75953",
            "url": "https://www.reactome.org/PathwayBrowser/#R-GGA-75953",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-GGA-76042",
            "url": "https://www.reactome.org/PathwayBrowser/#R-GGA-76042",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-GGA-9018519",
            "url": "https://www.reactome.org/PathwayBrowser/#R-GGA-9018519",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "NP_001075177",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001075177",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A8V0ZZE6",
            "url": "https://www.uniprot.org/uniprot/A0A8V0ZZE6",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A8V0ZZE6-1",
            "url": "https://www.uniprot.org/uniprot/A0A8V0ZZE6-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A1IIE5",
            "url": "https://www.uniprot.org/uniprot/A1IIE5",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A1IIE5-1",
            "url": "https://www.uniprot.org/uniprot/A1IIE5-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MAYQLYRNTTLGNSLQESLDELIQSQQITPQLALQVLLQFDKAINSALAQRVRNRVNFRGSLNTYRFCDNVWTFVLNDVEFREVTELVKVDKVKIVACDGKNTGSNAAE",
        "length": 109,
        "header": "tr|A1IIE5-1|A1IIE5_CHICK Isoform 1 of Transcription initiation factor IIA subunit 2  OS=Gallus gallus OX=9031 GN=GTF2A2 PE=2 SV=1 CANONICAL=A1IIE5-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A0A8V0ZZE6-1",
            "url": "https://www.uniprot.org/uniprotkb/A1IIE5/entry#A0A8V0ZZE6-1",
            "sequence": {
                "sequence": "MAYQLYRNTTLGNSLQESLDELIQGSLNTYRFCDNVWTFVLNDVEFREVTELVKVDKVKIVACDGKNTGSNAAE",
                "length": 74,
                "header": "tr|A0A8V0ZZE6-1|A1IIE5_CHICK Computationally mapped isoform of Transcription initiation factor IIA subunit 2  OS=Gallus gallus OX=9031 GN=GTF2A2 PE=2 SV=1 CANONICAL=A1IIE5-1"
            },
            "locus": {
                "chromosome": "10",
                "start_pos": 5417624,
                "end_pos": 5413376,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSGALT00010060334.1",
                        "url": "https://www.ensembl.org/id/ENSGALT00010060334.1"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSGALP00010037093.1",
                        "url": "https://www.ensembl.org/id/ENSGALP00010037093.1"
                    }
                ]
            }
        },
        {
            "isoform_ac": "A1IIE5-1",
            "url": "https://www.uniprot.org/uniprotkb/A1IIE5/entry#A1IIE5-1",
            "sequence": {
                "sequence": "MAYQLYRNTTLGNSLQESLDELIQSQQITPQLALQVLLQFDKAINSALAQRVRNRVNFRGSLNTYRFCDNVWTFVLNDVEFREVTELVKVDKVKIVACDGKNTGSNAAE",
                "length": 109,
                "header": "tr|A1IIE5-1|A1IIE5_CHICK Isoform 1 of Transcription initiation factor IIA subunit 2  OS=Gallus gallus OX=9031 GN=GTF2A2 PE=2 SV=1 CANONICAL=A1IIE5-1"
            },
            "locus": {
                "chromosome": "10",
                "start_pos": 5417624,
                "end_pos": 5413376,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSGALT00010060333.1",
                        "url": "https://www.ensembl.org/id/ENSGALT00010060333.1"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSGALP00010037092.1",
                        "url": "https://www.ensembl.org/id/ENSGALP00010037092.1"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [],
    "publication": [
        {
            "title": "Chromosomal position, structure, expression, and requirement of genes for chicken transcription factor IIA.",
            "journal": "Gene",
            "date": "2007",
            "authors": "Mabuchi Tomoko, Wakamatsu Toshifumi, Nakadai Tomoyoshi, Shimada Miho, Yamada Kazuhiko, Matsuda Yoichi, Tamura Taka-Aki",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A1IIE5",
                    "url": "https://www.uniprot.org/uniprot/A1IIE5"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "17544229",
                    "url": "https://glygen.org/publication/PubMed/17544229"
                }
            ]
        }
    ],
    "pathway": [
        {
            "id": "gga:770910",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+gga:770910",
            "resource": "KEGG Pathway"
        },
        {
            "id": "R-GGA-674695",
            "name": "RNA Polymerase II Pre-transcription Events",
            "url": "https://www.reactome.org/PathwayBrowser/#R-GGA-674695",
            "resource": "Reactome",
            "description": "RNA Polymerase II Pre-transcription Events"
        },
        {
            "id": "R-GGA-6807505",
            "name": "RNA polymerase II transcribes snRNA genes",
            "url": "https://www.reactome.org/PathwayBrowser/#R-GGA-6807505",
            "resource": "Reactome",
            "description": "RNA polymerase II transcribes snRNA genes"
        },
        {
            "id": "R-GGA-73776",
            "name": "RNA Polymerase II Promoter Escape",
            "url": "https://www.reactome.org/PathwayBrowser/#R-GGA-73776",
            "resource": "Reactome",
            "description": "RNA Polymerase II Promoter Escape"
        },
        {
            "id": "R-GGA-73779",
            "name": "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening",
            "url": "https://www.reactome.org/PathwayBrowser/#R-GGA-73779",
            "resource": "Reactome",
            "description": "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening"
        },
        {
            "id": "R-GGA-75953",
            "name": "RNA Polymerase II Transcription Initiation",
            "url": "https://www.reactome.org/PathwayBrowser/#R-GGA-75953",
            "resource": "Reactome",
            "description": "RNA Polymerase II Transcription Initiation"
        },
        {
            "id": "R-GGA-76042",
            "name": "RNA Polymerase II Transcription Initiation And Promoter Clearance",
            "url": "https://www.reactome.org/PathwayBrowser/#R-GGA-76042",
            "resource": "Reactome",
            "description": "RNA Polymerase II Transcription Initiation And Promoter Clearance"
        },
        {
            "id": "R-GGA-9018519",
            "name": "Estrogen-dependent gene expression",
            "url": "https://www.reactome.org/PathwayBrowser/#R-GGA-9018519",
            "resource": "Reactome",
            "description": "Estrogen-dependent gene expression"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "A0A480PU90-1",
            "protein_name": "Transcription initiation factor IIA subunit 2",
            "gene_name": "GTF2A2",
            "tax_id": 9823,
            "organism": "Sus scrofa",
            "sequence": {
                "sequence": "MAYQLYRNTTLGNSLQESLDELIQSQQITPQLALQVLLQFDKAINSALAQRVRNRVNFRGSLNTYRFCDNVWTFVLNDVEFREVTELIKVDKVKIVACDGKNTGSNTTE",
                "length": 109
            },
            "evidence": [
                {
                    "id": "A1IIE5",
                    "url": "https://omabrowser.org/oma/group/A1IIE5/",
                    "database": "OMA"
                }
            ],
            "glygen_name": "Pig",
            "common_name": "Pig"
        },
        {
            "uniprot_canonical_ac": "O08950-1",
            "protein_name": "Transcription initiation factor IIA subunit 2",
            "gene_name": "Gtf2a2",
            "tax_id": 10116,
            "organism": "Rattus norvegicus",
            "sequence": {
                "sequence": "MAYQLYRNTTLGNSLQESLDELIQSQQITPQLALQVLLQFDKAINSALAQRVRNRVNFRGSLNTYRFCDNVWTFVLNDVEFREVTELIKVDKVKIVACDGKNTGSNTTE",
                "length": 109
            },
            "evidence": [
                {
                    "id": "A1IIE5",
                    "url": "https://omabrowser.org/oma/group/A1IIE5/",
                    "database": "OMA"
                }
            ],
            "glygen_name": "Rat",
            "common_name": "Rat"
        },
        {
            "uniprot_canonical_ac": "P32774-1",
            "protein_name": "Transcription initiation factor IIA subunit 2",
            "gene_name": "TOA2",
            "tax_id": 559292,
            "organism": "Saccharomyces cerevisiae S288C",
            "sequence": {
                "sequence": "MAVPGYYELYRRSTIGNSLVDALDTLISDGRIEASLAMRVLETFDKVVAETLKDNTQSKLTVKGNLDTYGFCDDVWTFIVKNCQVTVEDSHRDASQNGSGDSQSVISVDKLRIVACNSKKSE",
                "length": 122
            },
            "evidence": [
                {
                    "id": "A1IIE5",
                    "url": "https://omabrowser.org/oma/group/A1IIE5/",
                    "database": "OMA"
                }
            ],
            "glygen_name": "Yeast",
            "common_name": "Baker's yeast"
        },
        {
            "uniprot_canonical_ac": "P52656-1",
            "protein_name": "Transcription initiation factor IIA subunit 2",
            "gene_name": "TfIIA-S",
            "tax_id": 7227,
            "organism": "Drosophila melanogaster",
            "sequence": {
                "sequence": "MSYQLYRNTTLGNTLQESLDELIQYGQITPGLAFKVLLQFDKSINNALNQRVKARVTFKAGKLNTYRFCDNVWTLMLNDVEFREVHEIVKVDKVKIVACDGKSGEF",
                "length": 106
            },
            "evidence": [
                {
                    "id": "A1IIE5",
                    "url": "https://omabrowser.org/oma/group/A1IIE5/",
                    "database": "OMA"
                }
            ],
            "glygen_name": "Fruit fly",
            "common_name": "Fruit fly"
        },
        {
            "uniprot_canonical_ac": "P52657-1",
            "protein_name": "Transcription initiation factor IIA subunit 2",
            "gene_name": "GTF2A2",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MAYQLYRNTTLGNSLQESLDELIQSQQITPQLALQVLLQFDKAINAALAQRVRNRVNFRGSLNTYRFCDNVWTFVLNDVEFREVTELIKVDKVKIVACDGKNTGSNTTE",
                "length": 109
            },
            "evidence": [
                {
                    "id": "A1IIE5",
                    "url": "https://omabrowser.org/oma/group/A1IIE5/",
                    "database": "OMA"
                }
            ],
            "glygen_name": "Human",
            "common_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q54ND1-1",
            "protein_name": "Transcription initiation factor IIA subunit 2",
            "gene_name": "gtf2a2",
            "tax_id": 44689,
            "organism": "Dictyostelium discoideum",
            "sequence": {
                "sequence": "MANKQNYYELYRKSTIGEALTDTLEELLINQYISNSLYQKILTQFDKTINEALSNTVKAKTTFKGSLHTYRFCDSVWTFILENAQFKTEANEIVKVDRVKIVACDANVQDAPPPK",
                "length": 115
            },
            "evidence": [
                {
                    "id": "A1IIE5",
                    "url": "https://omabrowser.org/oma/group/A1IIE5/",
                    "database": "OMA"
                }
            ],
            "glygen_name": "Cellular slime mold",
            "common_name": "Social amoeba"
        },
        {
            "uniprot_canonical_ac": "Q80ZM7-1",
            "protein_name": "Transcription initiation factor IIA subunit 2",
            "gene_name": "Gtf2a2",
            "tax_id": 10090,
            "organism": "Mus musculus",
            "sequence": {
                "sequence": "MAYQLYRNTTLGNSLQESLDELIQSQQITPQLALQVLLQFDKAINSALAQRVRNRVNFRGSLNTYRFCDNVWTFVLNDVEFREVTELIKVDKVKIVACDGKNTGSNTTE",
                "length": 109
            },
            "evidence": [
                {
                    "id": "A1IIE5",
                    "url": "https://omabrowser.org/oma/group/A1IIE5/",
                    "database": "OMA"
                }
            ],
            "glygen_name": "Mouse",
            "common_name": "Mouse"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Biological Process",
                "total": 3,
                "go_terms": [
                    {
                        "name": "positive regulation of transcription initiation by RNA polymerase II",
                        "id": "GO:0060261",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060261",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A1IIE5",
                                "url": "https://www.uniprot.org/uniprot/A1IIE5"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "RNA polymerase II preinitiation complex assembly",
                        "id": "GO:0051123",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051123",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A1IIE5",
                                "url": "https://www.uniprot.org/uniprot/A1IIE5"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "transcription initiation at RNA polymerase II promoter",
                        "id": "GO:0006367",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006367",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A1IIE5",
                                "url": "https://www.uniprot.org/uniprot/A1IIE5"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Cellular Component",
                "total": 3,
                "go_terms": [
                    {
                        "name": "cell junction",
                        "id": "GO:0030054",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030054",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A1IIE5",
                                "url": "https://www.uniprot.org/uniprot/A1IIE5"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "transcription factor TFIIA complex",
                        "id": "GO:0005672",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005672",
                        "evidence": [
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