{
    "uniprot_canonical_ac": "A0ZVR0-1",
    "uniprot_ac": "A0ZVR0",
    "uniprot_id": "A0ZVR0_PIG",
    "mass": {
        "chemical_mass": 53416.0,
        "monoisotopic_mass": 53416.0
    },
    "refseq": {
        "ac": "NP_001090897",
        "name": "interferon regulatory factor 7",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001090897"
    },
    "gene_names": [
        {
            "name": "IRF7",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/A0ZVR0",
            "id": "A0ZVR0"
        },
        {
            "name": "IRF7",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001090897",
            "id": "NP_001090897"
        },
        {
            "name": "Irf7",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A0ZVR0",
            "id": "A0ZVR0"
        }
    ],
    "protein_names": [
        {
            "name": "Interferon regulatory factor 7",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprotkb/A0ZVR0/entry#names_and_taxonomy",
            "id": "A0ZVR0"
        },
        {
            "name": "interferon regulatory factor 7",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001090897",
            "id": "NP_001090897"
        }
    ],
    "function": [
        {
            "annotation": "Expression of porcine fusion protein IRF7/3(5D) efficiently controls foot-and-mouth disease virus replication.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001090897",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001090897"
                },
                {
                    "database": "PubMed",
                    "id": "25031341",
                    "url": "https://glygen.org/publication/PubMed/25031341"
                }
            ]
        },
        {
            "annotation": "Key regulators involved in Porcine circovirus 2 infection were identified as IFNbeta, DDX58 (RIG-I), and IRF7.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001090897",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001090897"
                },
                {
                    "database": "PubMed",
                    "id": "29864504",
                    "url": "https://glygen.org/publication/PubMed/29864504"
                }
            ]
        },
        {
            "annotation": "N(pro) of classical swine fever virus (CSFV) interacts with IRF7; Zn-binding domain of N(pro) is essential for the interaction; results show CSFV N(pro) is capable of manipulating function of IRF7 in plasmacytoid dendritic cells",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001090897",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001090897"
                },
                {
                    "database": "PubMed",
                    "id": "21680532",
                    "url": "https://glygen.org/publication/PubMed/21680532"
                }
            ]
        },
        {
            "annotation": "Porcine Epidemic Diarrhea Virus Membrane Protein Interacted with IRF7 to Inhibit Type I IFN Production during Viral Infection.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001090897",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001090897"
                },
                {
                    "database": "PubMed",
                    "id": "34127522",
                    "url": "https://glygen.org/publication/PubMed/34127522"
                }
            ]
        }
    ],
    "disease": [],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Sus scrofa",
            "taxid": 9823,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A0ZVR0",
                    "url": "https://www.uniprot.org/uniprot/A0ZVR0"
                }
            ],
            "common_name": "Pig",
            "glygen_name": "Pig",
            "reference_species": "Sus scrofa [9823]"
        }
    ],
    "gene": [
        {
            "name": "IRF7",
            "url": "https://www.uniprot.org/uniprot/A0ZVR0",
            "locus": {
                "chromosome": "2",
                "start_pos": 372238,
                "end_pos": 375378,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSSSCG00000012853",
                        "url": "https://www.ensembl.org/id/ENSSSCG00000012853"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSSSCG00000012853",
            "url": "https://bgee.org/?page=gene&gene_id=ENSSSCG00000012853",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "cd00103",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00103",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "100037289",
            "url": "https://www.ncbi.nlm.nih.gov/gene/100037289",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "A0ZVR0",
            "url": "https://www.ebi.ac.uk/intact/interactors/id:A0ZVR0*",
            "database": "IntAct",
            "categories": [
                "Other"
            ]
        },
        {
            "id": "IPR001346",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001346",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR008984",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR008984",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR017855",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR017855",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR019471",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR019471",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR019817",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR019817",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR036388",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR036388",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR036390",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR036390",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "ssc:100037289",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+ssc:100037289",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "HEIAQME",
            "url": "https://omabrowser.org/oma/group/HEIAQME/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "3740806at2759",
            "url": "http://www.orthodb.org/?query=3740806at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR11949",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11949",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR11949:SF2",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11949:SF2",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF00605",
            "url": "http://pfam.xfam.org/family/PF00605",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF10401",
            "url": "http://pfam.xfam.org/family/PF10401",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-SSC-3134963",
            "url": "https://www.reactome.org/PathwayBrowser/#R-SSC-3134963",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-SSC-9013973",
            "url": "https://www.reactome.org/PathwayBrowser/#R-SSC-9013973",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-SSC-918233",
            "url": "https://www.reactome.org/PathwayBrowser/#R-SSC-918233",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-SSC-933541",
            "url": "https://www.reactome.org/PathwayBrowser/#R-SSC-933541",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-SSC-936964",
            "url": "https://www.reactome.org/PathwayBrowser/#R-SSC-936964",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-SSC-975110",
            "url": "https://www.reactome.org/PathwayBrowser/#R-SSC-975110",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "NP_001090897",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001090897",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A5K1US05",
            "url": "https://www.uniprot.org/uniprot/A0A5K1US05",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A5K1US05-1",
            "url": "https://www.uniprot.org/uniprot/A0A5K1US05-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0ZVR0",
            "url": "https://www.uniprot.org/uniprot/A0ZVR0",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0ZVR0-1",
            "url": "https://www.uniprot.org/uniprot/A0ZVR0-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MAAAPDRGCPRVLFGDWLLGEVSSGRYAGLRWLDEARTRFRVPWKHFARKDLGESDSRIFKAWAVARGRWPPRSSEGAQPIPEGALRASWKTNFRCALHSTRRFVMLQDNSGDPTDPHKVYMINPELGCGEGPGFNPGEEEALEDAPPPRGELPGPRLAAHTGERLRHELARPSPEPCTPSPAGDGGDLLLQALQQSCMEDHLLEAAWGVDLTPPEVPYAGPLPAPVPWKPQEAEPCTTLYPRVCTRMAGERGAASPSCSQLGLHAGPSLEALDLTIMYKGRTVLQEMVGGPSCVLLYGSPGPAGAAAEPQQVAFPSPAELPDQKQLHYTEKLLQHVAPGLQLEFRGPKLWARRLGKCKVYWEVGGPLGSGSPSTPACLLPRDCDTPIFDFGTFFQELMEFRARRRQGSPHYTIYLGFGQDLSVGRPKEKSLVLVKLEPWLCRTQLESVQREGVSSLDSGSLSLCLSPSNSLYDELERFLMEVEQPA",
        "length": 487,
        "header": "tr|A0ZVR0-1|A0ZVR0_PIG Isoform 1 of Interferon regulatory factor 7  OS=Sus scrofa OX=9823 GN=IRF7 PE=1 SV=2 CANONICAL=A0ZVR0-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A0A5K1US05-1",
            "url": "https://www.uniprot.org/uniprotkb/A0ZVR0/entry#A0A5K1US05-1",
            "sequence": {
                "sequence": "MAAAPDRGCPRVLFGDWLLGEVSSGRYAGLRWLDEARTRFRVPWKHFARKDLGESDSRIFKAWAVARGRWPPRSSEGAQPIPEGALRASWKTNFRCALHSTRRFVMLQDNSGDPTDPHKVYMINPELGCGEGPGFNPGEEEALEDAPPPRGELPGPRLAAHTGERLRHELARPSPEPCTPSPAGDGGDLLLQALQQSCMEDHLLEAAWGVDLTPPEVPYAGPLPAPVPWKPQEAEPCTTLYPRVCTRMAGERGAASPSCSQLGLHAGPSLEALDLTIMYKGRTVLQEMVGGPSCVLLYGSPGPAGAAAEPQQVAFPSPAELPDQKQLHYTEKLLPRDCDTPIFDFGTFFQELMEFRARRRQGSPHYTIYLGFGQDLSVGRPKEKSLVLVKLEPWLCRTQLESVQREGVSSLDSGSLSLCLSPSNSLYDELERFLMEVEQPA",
                "length": 441,
                "header": "tr|A0A5K1US05-1|A0A5K1US05_PIG Computationally mapped isoform of Interferon regulatory factor 7  OS=Sus scrofa OX=9823 GN=IRF7 PE=4 SV=2 CANONICAL=A0ZVR0-1"
            },
            "locus": {
                "chromosome": "2",
                "start_pos": 374747,
                "end_pos": 372287,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSSSCT00000035232.4",
                        "url": "https://www.ensembl.org/id/ENSSSCT00000035232.4"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSSSCP00000029329.4",
                        "url": "https://www.ensembl.org/id/ENSSSCP00000029329.4"
                    }
                ]
            }
        },
        {
            "isoform_ac": "A0ZVR0-1",
            "url": "https://www.uniprot.org/uniprotkb/A0ZVR0/entry#A0ZVR0-1",
            "sequence": {
                "sequence": "MAAAPDRGCPRVLFGDWLLGEVSSGRYAGLRWLDEARTRFRVPWKHFARKDLGESDSRIFKAWAVARGRWPPRSSEGAQPIPEGALRASWKTNFRCALHSTRRFVMLQDNSGDPTDPHKVYMINPELGCGEGPGFNPGEEEALEDAPPPRGELPGPRLAAHTGERLRHELARPSPEPCTPSPAGDGGDLLLQALQQSCMEDHLLEAAWGVDLTPPEVPYAGPLPAPVPWKPQEAEPCTTLYPRVCTRMAGERGAASPSCSQLGLHAGPSLEALDLTIMYKGRTVLQEMVGGPSCVLLYGSPGPAGAAAEPQQVAFPSPAELPDQKQLHYTEKLLQHVAPGLQLEFRGPKLWARRLGKCKVYWEVGGPLGSGSPSTPACLLPRDCDTPIFDFGTFFQELMEFRARRRQGSPHYTIYLGFGQDLSVGRPKEKSLVLVKLEPWLCRTQLESVQREGVSSLDSGSLSLCLSPSNSLYDELERFLMEVEQPA",
                "length": 487,
                "header": "tr|A0ZVR0-1|A0ZVR0_PIG Isoform 1 of Interferon regulatory factor 7  OS=Sus scrofa OX=9823 GN=IRF7 PE=1 SV=2 CANONICAL=A0ZVR0-1"
            },
            "locus": {}
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [],
    "publication": [
        {
            "title": "Classical swine fever virus Npro interacts with interferon regulatory factor 3 and induces its proteasomal degradation.",
            "journal": "J. Virol.",
            "date": "2007",
            "authors": "Bauhofer Oliver, Summerfield Artur, Sakoda Yoshihiro, Tratschin Jon-Duri, Hofmann Martin A, Ruggli Nicolas",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A0ZVR0",
                    "url": "https://www.uniprot.org/uniprot/A0ZVR0"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "17215286",
                    "url": "https://glygen.org/publication/PubMed/17215286"
                }
            ]
        },
        {
            "title": "Classical swine fever virus N(pro) limits type I interferon induction in plasmacytoid dendritic cells by interacting with interferon regulatory factor 7.",
            "journal": "Journal of virology",
            "date": "2011-08",
            "authors": "Fiebach Ana R, Guzylack-Piriou Laurence, Python Sylvie, Summerfield Artur, Ruggli Nicolas",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001090897",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001090897"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "21680532",
                    "url": "https://glygen.org/publication/PubMed/21680532"
                }
            ]
        },
        {
            "title": "An intronic polymorphism in the porcine IRF7 gene is associated with better health and immunity of the host during Sarcocystis infection, and affects interferon signalling.",
            "journal": "Anim. Genet.",
            "date": "2011",
            "authors": "Brock A J, Broke A, Matika O, Wilson A D, Anderson J, Morin A-C, Finlayson H A, Reiner G, Willems H, Bishop S C, Archibald A L, Ait-Ali T",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A0ZVR0",
                    "url": "https://www.uniprot.org/uniprot/A0ZVR0"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "21749421",
                    "url": "https://glygen.org/publication/PubMed/21749421"
                }
            ]
        },
        {
            "title": "Expression of porcine fusion protein IRF7/3(5D) efficiently controls foot-and-mouth disease virus replication.",
            "journal": "Journal of virology",
            "date": "2014-10",
            "authors": "Ram\u00edrez-Carvajal Lisbeth, D\u00edaz-San Segundo Fayna, Hickman Danielle, Long Charles R, Zhu James, Rodr\u00edguez Luis L, de los Santos Teresa",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001090897",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001090897"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "25031341",
                    "url": "https://glygen.org/publication/PubMed/25031341"
                }
            ]
        },
        {
            "title": "Porcine circovirus 2 infection induces IFN\u03b2 expression through increased expression of genes involved in RIG-I and IRF7 signaling pathways.",
            "journal": "Virus research",
            "date": "2018-07-15",
            "authors": "Dvorak Cheryl M T, Puvanendiran Sumathy, Murtaugh Michael P",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001090897",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001090897"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "29864504",
                    "url": "https://glygen.org/publication/PubMed/29864504"
                }
            ]
        },
        {
            "title": "Porcine Epidemic Diarrhea Virus Membrane Protein Interacted with IRF7 to Inhibit Type I IFN Production during Viral Infection.",
            "journal": "Journal of immunology (Baltimore, Md. : 1950)",
            "date": "2021",
            "authors": "Li S, Zhu Z, Yang F, Cao W, Yang J, Ma C, Zhao Z, Tian H, Liu X, Ma J, Xiao S, Zheng H",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001090897",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001090897"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "34127522",
                    "url": "https://glygen.org/publication/PubMed/34127522"
                }
            ]
        }
    ],
    "pathway": [
        {
            "id": "ssc:100037289",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+ssc:100037289",
            "resource": "KEGG Pathway"
        },
        {
            "id": "R-SSC-3134963",
            "name": "DEx/H-box helicases activate type I IFN and inflammatory cytokines production",
            "url": "https://www.reactome.org/PathwayBrowser/#R-SSC-3134963",
            "resource": "Reactome",
            "description": "DEx/H-box helicases activate type I IFN and inflammatory cytokines production"
        },
        {
            "id": "R-SSC-9013973",
            "name": "TICAM1-dependent activation of IRF3/IRF7",
            "url": "https://www.reactome.org/PathwayBrowser/#R-SSC-9013973",
            "resource": "Reactome",
            "description": "TICAM1-dependent activation of IRF3/IRF7"
        },
        {
            "id": "R-SSC-918233",
            "name": "TRAF3-dependent IRF activation pathway",
            "url": "https://www.reactome.org/PathwayBrowser/#R-SSC-918233",
            "resource": "Reactome",
            "description": "TRAF3-dependent IRF activation pathway"
        },
        {
            "id": "R-SSC-933541",
            "name": "TRAF6 mediated IRF7 activation",
            "url": "https://www.reactome.org/PathwayBrowser/#R-SSC-933541",
            "resource": "Reactome",
            "description": "TRAF6 mediated IRF7 activation"
        },
        {
            "id": "R-SSC-936964",
            "name": "Activation of IRF3, IRF7 mediated by TBK1, IKK (IKBKE)",
            "url": "https://www.reactome.org/PathwayBrowser/#R-SSC-936964",
            "resource": "Reactome",
            "description": "Activation of IRF3, IRF7 mediated by TBK1, IKK\u03b5 (IKBKE)"
        },
        {
            "id": "R-SSC-975110",
            "name": "TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling",
            "url": "https://www.reactome.org/PathwayBrowser/#R-SSC-975110",
            "resource": "Reactome",
            "description": "TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "A0A8V0ZYC7-1",
            "protein_name": "Interferon regulatory factor 7",
            "gene_name": "IRF7",
            "tax_id": 9031,
            "organism": "Gallus gallus",
            "sequence": {
                "sequence": "MAALDSEGDAQKLRFGPWLLNAVSSGLYRGLCWIDPDRRIFRIPWKHNARKDVTSSDVEIFKAWAKASGRYEGNAEDPAKWKTNFRCALRSTHMFMLLEDRSKCNDDPHKVYAVASGVPNDRGSGGPVAGALQQQPQLLLNHHDLALENTPTDSTEGVAAAALTQVDLDLLQSVLQHCNISALGSQPTLWAHTGDALPEDALLLPGQDGCLPGPQFQDWRQLEEPLLLGNQPLTGGGCGQDGAGALPVSEECAIPAPSPAEELLFQSANPAPPPPAGDIGGLPPLLDITIYYRGKMVYQEQVDDSRCVLAYQPLDPAVAEQRLVLFPSPASLPDPRQRRYTENLLEVAGLRLEQRAGQLLATRLKKCKVFWALSQQLEGGEPPLNLLHRDQETTIFDFRVFCTELRDFRDSRRERSPDFTIFLCFGQCFSSTKPKESKLILVKVSGPEVASEAEGDGYHGPGLSGLGQMDCPVHPLLFLVEGQGCTGKRGNCPKPHPKLCPCVVAAGSPVLRVLVRAGAAGRSLLPQQWQRQPAAL",
                "length": 536
            },
            "evidence": [
                {
                    "id": "A0ZVR0",
                    "url": "https://omabrowser.org/oma/group/A0ZVR0/",
                    "database": "OMA"
                }
            ],
            "glygen_name": "Chicken",
            "common_name": "Chicken"
        },
        {
            "uniprot_canonical_ac": "P70434-1",
            "protein_name": "Interferon regulatory factor 7",
            "gene_name": "Irf7",
            "tax_id": 10090,
            "organism": "Mus musculus",
            "sequence": {
                "sequence": "MAEVRGVQRVLFGDWLLGEVSSGQYEGLQWLNEARTVFRVPWKHFGRRDLDEEDAQIFKAWAVARGRWPPSGVNLPPPEAEAAERRERRGWKTNFRCALHSTGRFILRQDNSGDPVDPHKVYELSRELGSTVGPATENREEVSLSNALPTQGVSPGSFLARENAGLQTPSPLLSSDAGDLLLQVLQYSHILESESGADPVPPQAPGQEQDRVYEEPYAAWQVEAVPSPRPQQPALTERSLGFLDVTIMYKGRTVLQAVVGHPRCVFLYSPMAPAVRTSEPQPVIFPSPAELPDQKQLHYTETLLQHVSPGLQLELRGPSLWALRMGKCKVYWEVGSPMGTTGPSTPPQLLERNRHTPIFDFSTFFRELEEFRARRRQGSPHYTIYLGFGQDLSAGRPKEKTLILVKLEPWVCKAYLEGVQREGVSSLDSSSLGLCLSSTNSLYEDIEHFLMDLGQWP",
                "length": 457
            },
            "evidence": [
                {
                    "id": "A0ZVR0",
                    "url": "https://omabrowser.org/oma/group/A0ZVR0/",
                    "database": "OMA"
                }
            ],
            "glygen_name": "Mouse",
            "common_name": "Mouse"
        },
        {
            "uniprot_canonical_ac": "Q3SWU2-1",
            "protein_name": "Interferon regulatory factor 7",
            "gene_name": "Irf7",
            "tax_id": 10116,
            "organism": "Rattus norvegicus",
            "sequence": {
                "sequence": "MAEVRGVQRVLFGDWLLGEVSSGRYEGLQWLNEAHTVFRVPWKHFSRRDLDEADAQIFKAWAVARGRWPPSGVNLPPPEAEAAERRGWKTNFRCALRSTGRFILRQDNSGDPADPHKVYELSPELGSTTGPALENREEVTLSSALPTQGMSLGSFLARGNAGLQTPSPLLSGDAGDLLLQVLQYSHLLDSESRADSVPPQASGQEQEHLPEEPHAAWQMEATSSPRLQHPVLMTERNLGSLDVTIMYKGRTVLQAMVGHPRCVFLYSPVGSAIRTSEPQPVIFPSPAELPDQKQLHYTETLLQHVSPGLQLELRGPSLWALRMGKCKVYWEVGSPMGSTNPSTPAQLLERNCHTPIFDFSTFFRELEEFRARRRQGSPHYTIYLGFGQDLSAGRPKEKSLILVKLEPWLCKTHLEGVQREGVSSLDSSSLGLCLSSTNSLYDDIEHFLMDLGQWA",
                "length": 455
            },
            "evidence": [
                {
                    "id": "A0ZVR0",
                    "url": "https://omabrowser.org/oma/group/A0ZVR0/",
                    "database": "OMA"
                }
            ],
            "glygen_name": "Rat",
            "common_name": "Rat"
        },
        {
            "uniprot_canonical_ac": "Q92985-1",
            "protein_name": "Interferon regulatory factor 7",
            "gene_name": "IRF7",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MALAPERAAPRVLFGEWLLGEISSGCYEGLQWLDEARTCFRVPWKHFARKDLSEADARIFKAWAVARGRWPPSSRGGGPPPEAETAERAGWKTNFRCALRSTRRFVMLRDNSGDPADPHKVYALSRELCWREGPGTDQTEAEAPAAVPPPQGGPPGPFLAHTHAGLQAPGPLPAPAGDKGDLLLQAVQQSCLADHLLTASWGADPVPTKAPGEGQEGLPLTGACAGGPGLPAGELYGWAVETTPSPGPQPAALTTGEAAAPESPHQAEPYLSPSPSACTAVQEPSPGALDVTIMYKGRTVLQKVVGHPSCTFLYGPPDPAVRATDPQQVAFPSPAELPDQKQLRYTEELLRHVAPGLHLELRGPQLWARRMGKCKVYWEVGGPPGSASPSTPACLLPRNCDTPIFDFRVFFQELVEFRARQRRGSPRYTIYLGFGQDLSAGRPKEKSLVLVKLEPWLCRVHLEGTQREGVSSLDSSSLSLCLSSANSLYDDIECFLMELEQPA",
                "length": 503
            },
            "evidence": [
                {
                    "id": "A0ZVR0",
                    "url": "https://omabrowser.org/oma/group/A0ZVR0/",
                    "database": "OMA"
                }
            ],
            "glygen_name": "Human",
            "common_name": "Human"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Biological Process",
                "total": 13,
                "go_terms": [
                    {
                        "name": "positive regulation of interferon-alpha production",
                        "id": "GO:0032727",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032727",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0ZVR0",
                                "url": "https://www.uniprot.org/uniprot/A0ZVR0"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "regulation of MyD88-dependent toll-like receptor signaling pathway",
                        "id": "GO:0034124",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034124",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0ZVR0",
                                "url": "https://www.uniprot.org/uniprot/A0ZVR0"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "regulation of MyD88-independent toll-like receptor signaling pathway",
                        "id": "GO:0034127",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034127",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0ZVR0",
                                "url": "https://www.uniprot.org/uniprot/A0ZVR0"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "positive regulation of transcription by RNA polymerase II",
                        "id": "GO:0045944",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0ZVR0",
                                "url": "https://www.uniprot.org/uniprot/A0ZVR0"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "defense response to virus",
                        "id": "GO:0051607",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051607",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0ZVR0",
                                "url": "https://www.uniprot.org/uniprot/A0ZVR0"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "type I interferon-mediated signaling pathway",
                        "id": "GO:0060337",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060337",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0ZVR0",
                                "url": "https://www.uniprot.org/uniprot/A0ZVR0"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "positive regulation of type I interferon-mediated signaling pathway",
                        "id": "GO:0060340",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060340",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0ZVR0",
                                "url": "https://www.uniprot.org/uniprot/A0ZVR0"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "immunoglobulin mediated immune response",
                        "id": "GO:0016064",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016064",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0ZVR0",
                                "url": "https://www.uniprot.org/uniprot/A0ZVR0"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "regulation of adaptive immune response",
                        "id": "GO:0002819",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002819",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0ZVR0",
                                "url": "https://www.uniprot.org/uniprot/A0ZVR0"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "positive regulation of interferon-beta production",
                        "id": "GO:0032728",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032728",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0ZVR0",
                                "url": "https://www.uniprot.org/uniprot/A0ZVR0"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cytoplasmic pattern recognition receptor signaling pathway",
                        "id": "GO:0002753",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002753",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0ZVR0",
                                "url": "https://www.uniprot.org/uniprot/A0ZVR0"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "regulation of transcription by RNA polymerase II",
                        "id": "GO:0006357",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0ZVR0",
                                "url": "https://www.uniprot.org/uniprot/A0ZVR0"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "positive regulation of DNA-templated transcription",
                        "id": "GO:0045893",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045893",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0ZVR0",
                                "url": "https://www.uniprot.org/uniprot/A0ZVR0"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Cellular Component",
                "total": 4,
                "go_terms": [
                    {
                        "name": "nucleoplasm",
                        "id": "GO:0005654",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0ZVR0",
                                "url": "https://www.uniprot.org/uniprot/A0ZVR0"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cytosol",
                        "id": "GO:0005829",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0ZVR0",
                                "url": "https://www.uniprot.org/uniprot/A0ZVR0"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "chromatin",
                        "id": "GO:0000785",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000785",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0ZVR0",
                                "url": "https://www.uniprot.org/uniprot/A0ZVR0"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "nucleus",
                        "id": "GO:0005634",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0ZVR0",
                                "url": "https://www.uniprot.org/uniprot/A0ZVR0"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Molecular Function",
                "total": 4,
                "go_terms": [
                    {
                        "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding",
                        "id": "GO:0000978",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0ZVR0",
                                "url": "https://www.uniprot.org/uniprot/A0ZVR0"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "DNA-binding transcription factor activity, RNA polymerase II-specific",
                        "id": "GO:0000981",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0ZVR0",
                                "url": "https://www.uniprot.org/uniprot/A0ZVR0"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "DNA-binding transcription factor activity",
                        "id": "GO:0003700",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003700",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0ZVR0",
                                "url": "https://www.uniprot.org/uniprot/A0ZVR0"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "transcription cis-regulatory region binding",
                        "id": "GO:0000976",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000976",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0ZVR0",
                                "url": "https://www.uniprot.org/uniprot/A0ZVR0"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            }
        ]
    },
    "pro_annotation": [],
    "site_annotation": [],
    "ptm_annotation": [],
    "interactions": [],
    "reactions": [],
    "reaction_participants": [],
    "reaction_enzymes": [],
    "biomarkers": [],
    "synthesized_glycans": [],
    "enzyme_annotation": [],
    "cluster_types": [
        {
            "name": "isoformset.uniprotkb",
            "label": "Isoforms"
        },
        {
            "name": "homologset.oma",
            "label": "OMA Homologs"
        }
    ],
    "sequence_features": {
        "n_linked_sites": [],
        "o_linked_sites": [],
        "snv_sites": [],
        "glycation_sites": [],
        "phosphorylation_sites": [],
        "sequon_annotation_sites": []
    },
    "section_stats": [
        {
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                },
                {
                    "field": "total_sites",
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                {
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                {
                    "field": "n_linked_glycan_sites",
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                },
                {
                    "field": "o_linked_glycans",
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                },
                {
                    "field": "o_linked_glycan_sites",
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            ],
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        {
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            ],
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        {
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                {
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            ],
            "sort_fields": []
        },
        {
            "table_id": "snv",
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            ],
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        {
            "table_id": "snv_disease",
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        {
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        {
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            "sort_fields": [
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    ]
}