{ "uniprot_canonical_ac": "A0ZPS0-1", "uniprot_ac": "A0ZPS0", "uniprot_id": "A0ZPS0_CHICK", "mass": { "chemical_mass": 48530.0, "monoisotopic_mass": 48530.0 }, "refseq": { "ac": "NP_001074970", "name": "cholecystokinin receptor type A", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074970" }, "gene_names": [ { "name": "CCK1R", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A0ZPS0", "id": "A0ZPS0" }, { "name": "CCKAR", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074970", "id": "NP_001074970" }, { "name": "CCKAR", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A0ZPS0", "id": "A0ZPS0" } ], "protein_names": [ { "name": "Cholecystokinin receptor type A", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprotkb/A0ZPS0/entry#names_and_taxonomy", "id": "A0ZPS0" }, { "name": "Cholecystokinin-1 receptor", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0ZPS0/entry#names_and_taxonomy", "id": "A0ZPS0" }, { "name": "cholecystokinin receptor type A", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074970", "id": "NP_001074970" } ], "function": [ { "annotation": "Polymorphisms of the CCKAR gene were genotyped and investigated its association with growth traits in a Hinai-dori F(2) intercross population.", "evidence": [ { "database": "RefSeq", "id": "NP_001074970", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074970" }, { "database": "PubMed", "id": "21947885", "url": "https://glygen.org/publication/PubMed/21947885" } ] }, { "annotation": "Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.", "evidence": [ { "database": "UniProtKB", "id": "A0ZPS0", "url": "https://www.uniprot.org/uniprot/A0ZPS0#function" }, { "database": "UniProtKB", "id": "ARBA00025653", "url": "https://www.uniprot.org/uniprot/ARBA00025653#function" } ] }, { "annotation": "Using 16 generations of a cross between a fast and a relatively slow growing strain of chicken has identified a region on chromosome 4 downstream of the CCKAR gene, which is responsible for up to a 19% difference in body weight", "evidence": [ { "database": "RefSeq", "id": "NP_001074970", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074970" }, { "database": "PubMed", "id": "23443924", "url": "https://glygen.org/publication/PubMed/23443924" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Gallus gallus", "taxid": 9031, "evidence": [ { "database": "UniProtKB", "id": "A0ZPS0", "url": "https://www.uniprot.org/uniprot/A0ZPS0" } ], "common_name": "Chicken", "glygen_name": "Chicken", "reference_species": "Gallus gallus [9031]" } ], "gene": [ { "name": "CCK1R", "url": "https://www.uniprot.org/uniprot/A0ZPS0", "locus": {} } ], "crossref": [ { "id": "ENSGALG00000030801", "url": "https://bgee.org/?page=gene&gene_id=ENSGALG00000030801", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd15978", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15978", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "422801", "url": "https://www.ncbi.nlm.nih.gov/gene/422801", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000596", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000596", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009126", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009126", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036472", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036472", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "gga:422801", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+gga:422801", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "SNISPPC", "url": "https://omabrowser.org/oma/group/SNISPPC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "3686620at2759", "url": "http://www.orthodb.org/?query=3686620at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24238", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24238", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24238:SF77", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24238:SF77", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00001", "url": "http://pfam.xfam.org/family/PF00001", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF09193", "url": "http://pfam.xfam.org/family/PF09193", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "R-GGA-375276", "url": "https://www.reactome.org/PathwayBrowser/#R-GGA-375276", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-GGA-416476", "url": "https://www.reactome.org/PathwayBrowser/#R-GGA-416476", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_001074970", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074970", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0ZPS0", "url": "https://www.uniprot.org/uniprot/A0ZPS0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ZPS0-1", "url": "https://www.uniprot.org/uniprot/A0ZPS0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEIVDASFLENSTNITALLCDILLENETFYCVDDPPYSSKDLHQIIRILLYCLIFLLSVLGNILVITVLIRNKQMRTVTNTFLLSLAVSDLMLCLFCMPFTLIPNLLKDFIFGSTVCKTATYFMGISVSVSTFNLVAISLERYSAICKPLQSRVWQTKSHALKVIAATWCVSFTIMSPYPIYSKLVPFTKYNNSTANMCRLLWPSDVIQQSWYTFLLLILFLIPGIIMMVAYGLISLELYRGIKFDTSQRRSSRERKGSTSIAKYEDGDGCYLHKAKRKRKVPLQQLSTMSNSKIDRVRSSSSSANLMAKKLVIRMLMVIVVLFFICWTPIFSVNAWRAFDTASADLHLSGAPISFIHLLSYTSACVNPIIYCFMNKRFRMGFLATFTCCAKQKPPVIRGEVGDEEEGKTTRASLSKCSYTHMNMSAPP", "length": 429, "header": "tr|A0ZPS0-1|A0ZPS0_CHICK Isoform 1 of Cholecystokinin receptor type A OS=Gallus gallus OX=9031 GN=CCK1R PE=2 SV=1 CANONICAL=A0ZPS0-1" }, "isoforms": [ { "isoform_ac": "A0ZPS0-1", "url": "https://www.uniprot.org/uniprotkb/A0ZPS0/entry#A0ZPS0-1", "sequence": { "sequence": "MEIVDASFLENSTNITALLCDILLENETFYCVDDPPYSSKDLHQIIRILLYCLIFLLSVLGNILVITVLIRNKQMRTVTNTFLLSLAVSDLMLCLFCMPFTLIPNLLKDFIFGSTVCKTATYFMGISVSVSTFNLVAISLERYSAICKPLQSRVWQTKSHALKVIAATWCVSFTIMSPYPIYSKLVPFTKYNNSTANMCRLLWPSDVIQQSWYTFLLLILFLIPGIIMMVAYGLISLELYRGIKFDTSQRRSSRERKGSTSIAKYEDGDGCYLHKAKRKRKVPLQQLSTMSNSKIDRVRSSSSSANLMAKKLVIRMLMVIVVLFFICWTPIFSVNAWRAFDTASADLHLSGAPISFIHLLSYTSACVNPIIYCFMNKRFRMGFLATFTCCAKQKPPVIRGEVGDEEEGKTTRASLSKCSYTHMNMSAPP", "length": 429, "header": "tr|A0ZPS0-1|A0ZPS0_CHICK Isoform 1 of Cholecystokinin receptor type A OS=Gallus gallus OX=9031 GN=CCK1R PE=2 SV=1 CANONICAL=A0ZPS0-1" }, "locus": { "chromosome": "4", "start_pos": 72735407, "end_pos": 72729658, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSGALT00010025629.1", "url": "https://www.ensembl.org/id/ENSGALT00010025629.1" }, { "database": "Ensembl Peptide", "id": "ENSGALP00010014448.1", "url": "https://www.ensembl.org/id/ENSGALP00010014448.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Association between cholecystokinin type A receptor haplotypes and growth traits in Japanese Hinai-dori crossbred chickens.", "journal": "Molecular biology reports", "date": "2012-04", "authors": "Rikimaru Kazuhiro, Komatsu Megumi, Suzuki Keiichi, Uemoto Yoshinobu, Takeda Hisato, Takahashi Hideaki", "evidence": [ { "database": "RefSeq", "id": "NP_001074970", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074970" } ], "reference": [ { "type": "PubMed", "id": "21947885", "url": "https://glygen.org/publication/PubMed/21947885" } ] }, { "title": "Decreased expression of the satiety signal receptor CCKAR is responsible for increased growth and body weight during the domestication of chickens.", "journal": "American journal of physiology. Endocrinology and metabolism", "date": "2013-05-01", "authors": "Dunn Ian C, Meddle Simone L, Wilson Peter W, Wardle Chloe A, Law Andy S, Bishop Valerie R, Hindar Camilla, Robertson Graeme W, Burt Dave W, Ellison Stephanie J H, Morrice David M, Hocking Paul M", "evidence": [ { "database": "RefSeq", "id": "NP_001074970", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074970" } ], "reference": [ { "type": "PubMed", "id": "23443924", "url": "https://glygen.org/publication/PubMed/23443924" } ] } ], "pathway": [ { "id": "gga:422801", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+gga:422801", "resource": "KEGG Pathway" }, { "id": "R-GGA-375276", "name": "Peptide ligand-binding receptors", "url": "https://www.reactome.org/PathwayBrowser/#R-GGA-375276", "resource": "Reactome", "description": "Peptide ligand-binding receptors" }, { "id": "R-GGA-416476", "name": "G alpha (q) signalling events", "url": "https://www.reactome.org/PathwayBrowser/#R-GGA-416476", "resource": "Reactome", "description": "G alpha (q) signalling events" } ], "orthologs": [ { "uniprot_canonical_ac": "I3LFK5-1", "protein_name": "Cholecystokinin receptor type A", "gene_name": "CCKAR", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MDVVHSLLMNGSNITPPCELGIENETLFCLDQPHPSQEWQPAVQILLYSVIFLLSILGNTLVITVLIRNKRMRTVTNIFLLSLAVSDLLLCLVCMPFNLIPNLLKDFIFGSAVCKITTYFMGTSVSVSTFNLVAISLERYGAICKPLQSRVWQTKSHALKVIAATWCLSFTIMTPYPIYSSLVPFTKSNNQTANMCRFLLPNDVMQQSWHTFLLLILFLIPGIVMMVAYGLISLELYQGIKFDASQKKSARERNPSTGSSGRYEDSDGCYLQKSKSPRKLQLQQLSTSGGSKVNRIRSSSPAANLMAKKRVIRMLVVIVILFFLCWMPIFSANAWRAFDAASAERRLSGAPISFILLLSYTSSCVNPIIYCFMNQRFRLGFLATFPCCPNPGPPGARGELGEEAESRTTRASLSRCSYSHASPAAPPP", "length": 428 }, "evidence": [ { "id": "A0ZPS0", "url": "https://omabrowser.org/oma/group/A0ZPS0/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "O08786-1", "protein_name": "Cholecystokinin receptor type A", "gene_name": "Cckar", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDVVDSLLMNGSNITPPCELGLENETLFCLDQPQPSKEWQSAVQILLYSFIFLLSVLGNTLVITVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFNLIPNLLKDFIFGSAVCKTTTYFMGTSVSVSTFNLVAISLERYGAICRPLQSRVWQTKSHALKVIAATWCLSFTIMTPYPIYSNLVPFTKNNNQTANMCRFLLPSDAMQQSWQTFLLLILFLIPGVVMVVAYGLISLELYQGIKFDASQKKSAKEKRLSSGGGGGGGSSSSRYEDSDGCYLQKSRPPRKLELQQLSTSSSGGRINRIRSSGSAANLIAKKRVIRMLIVIVVLFFLCWMPIFSANAWRAYDTVSAEKHLSGTPISFILLLSYTSSCVNPIIYCFMNKRFRLGFMATFPCCPNPGPTGVRGEVGEEEDGRTIRASLSRYSYSHMSTSAPPH", "length": 436 }, "evidence": [ { "id": "A0ZPS0", "url": "https://omabrowser.org/oma/group/A0ZPS0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P30551-1", "protein_name": "Cholecystokinin receptor type A", "gene_name": "Cckar", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSHSPARQHLVESSRMDVVDSLLMNGSNITPPCELGLENETLFCLDQPQPSKEWQSALQILLYSIIFLLSVLGNTLVITVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFNLIPNLLKDFIFGSAVCKTTTYFMGTSVSVSTFNLVAISLERYGAICRPLQSRVWQTKSHALKVIAATWCLSFTIMTPYPIYSNLVPFTKNNNQTANMCRFLLPSDAMQQSWQTFLLLILFLLPGIVMVVAYGLISLELYQGIKFDASQKKSAKEKKPSTGSSTRYEDSDGCYLQKSRPPRKLELQQLSSGSGGSRLNRIRSSSSAANLIAKKRVIRMLIVIVVLFFLCWMPIFSANAWRAYDTVSAEKHLSGTPISFILLLSYTSSCVNPIIYCFMNKRFRLGFMATFPCCPNPGPPGVRGEVGEEEDGRTIRALLSRYSYSHMSTSAPPP", "length": 444 }, "evidence": [ { "id": "A0ZPS0", "url": "https://omabrowser.org/oma/group/A0ZPS0/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P32238-1", "protein_name": "Cholecystokinin receptor type A", "gene_name": "CCKAR", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDVVDSLLVNGSNITPPCELGLENETLFCLDQPRPSKEWQPAVQILLYSLIFLLSVLGNTLVITVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFNLIPNLLKDFIFGSAVCKTTTYFMGTSVSVSTFNLVAISLERYGAICKPLQSRVWQTKSHALKVIAATWCLSFTIMTPYPIYSNLVPFTKNNNQTANMCRFLLPNDVMQQSWHTFLLLILFLIPGIVMMVAYGLISLELYQGIKFEASQKKSAKERKPSTTSSGKYEDSDGCYLQKTRPPRKLELRQLSTGSSSRANRIRSNSSAANLMAKKRVIRMLIVIVVLFFLCWMPIFSANAWRAYDTASAERRLSGTPISFILLLSYTSSCVNPIIYCFMNKRFRLGFMATFPCCPNPGPPGARGEVGEEEEGGTTGASLSRFSYSHMSASVPPQ", "length": 428 }, "evidence": [ { "id": "A0ZPS0", "url": "https://omabrowser.org/oma/group/A0ZPS0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q7M3J6-1", "protein_name": "Gastrin/cholecystokinin type B receptor", "gene_name": "CCKLR-17D3", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MFNYEEGDADQAAMAAAAAYRALLDYYANAPSAAGHIVSLNVAPYNGTGNGGTVSLAGNATSSYGDDDRDGYMDTEPSDLVTELAFSLGTSSSPSPSSTPASSSSTSTGMPVWLIPSYSMILLFAVLGNLLVISTLVQNRRMRTITNVFLLNLAISDMLLGVLCMPVTLVGTLLRNFIFGEFLCKLFQFSQAASVAVSSWTLVAISCERYYAICHPLRSRSWQTISHAYKIIGFIWLGGILCMTPIAVFSQLIPTSRPGYCKCREFWPDQGYELFYNILLDFLLLVLPLLVLCVAYILITRTLYVGMAKDSGRILQQSLPVSATTAGGSAPNPGTSSSSNCILVLTATAVYNENSNNNNGNSEGSAGGGSTNMATTTLTTRPTAPTVITTTTTTTVTLAKTSSPSIRVHDAALRRSNEAKTLESKKRVVKMLFVLVLEFFICWTPLYVINTMVMLIGPVVYEYVDYTAISFLQLLAYSSSCCNPITYCFMNASFRRAFVDTFKGLPWRRGAGASGGVGGAAGGGLSASQAGAGPGAYASANTNISLNPGLAMGMGTWRSRSRHEFLNAVVTTNSAAAAVNSPQL", "length": 584 }, "evidence": [ { "id": "A0ZPS0", "url": "https://omabrowser.org/oma/group/A0ZPS0/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0ZPS0", "url": "https://www.uniprot.org/uniprot/A0ZPS0" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0ZPS0", "url": "https://www.uniprot.org/uniprot/A0ZPS0" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0ZPS0", "url": "https://www.uniprot.org/uniprot/A0ZPS0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "G protein-coupled receptor signaling pathway", "id": "GO:0007186", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007186", "evidence": [ { "database": "UniProtKB", "id": "A0ZPS0", "url": "https://www.uniprot.org/uniprot/A0ZPS0" } ], "pmid": "" }, { "name": "axonogenesis", "id": "GO:0007409", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007409", "evidence": [ { "database": "UniProtKB", "id": "A0ZPS0", "url": "https://www.uniprot.org/uniprot/A0ZPS0" } ], "pmid": "" }, { "name": "forebrain development", "id": "GO:0030900", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030900", "evidence": [ { "database": "UniProtKB", "id": "A0ZPS0", "url": "https://www.uniprot.org/uniprot/A0ZPS0" } ], "pmid": "" }, { "name": "regulation of hormone secretion", "id": "GO:0046883", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046883", "evidence": [ { "database": "UniProtKB", "id": "A0ZPS0", "url": "https://www.uniprot.org/uniprot/A0ZPS0" } ], "pmid": "" }, { "name": "neuron migration", "id": "GO:0001764", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001764", "evidence": [ { "database": "UniProtKB", "id": "A0ZPS0", "url": "https://www.uniprot.org/uniprot/A0ZPS0" } ], "pmid": "" }, { "name": "cellular response to hormone stimulus", "id": "GO:0032870", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032870", "evidence": [ { "database": "UniProtKB", "id": "A0ZPS0", "url": "https://www.uniprot.org/uniprot/A0ZPS0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "peptide hormone binding", "id": "GO:0017046", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017046", "evidence": [ { "database": "UniProtKB", "id": "A0ZPS0", "url": "https://www.uniprot.org/uniprot/A0ZPS0" } ], "pmid": "" }, { "name": "peptide binding", "id": "GO:0042277", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042277", "evidence": [ { "database": "UniProtKB", "id": "A0ZPS0", "url": "https://www.uniprot.org/uniprot/A0ZPS0" } ], "pmid": "" }, { "name": "cholecystokinin receptor activity", "id": "GO:0004951", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004951", "evidence": [ { "database": "UniProtKB", "id": "A0ZPS0", "url": "https://www.uniprot.org/uniprot/A0ZPS0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 11, "end_pos": 13, "annotation": "n_glycosylation_sequon" }, { "start_pos": 14, "end_pos": 16, 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