{ "uniprot_canonical_ac": "A0A8V0XRI7-1", "uniprot_ac": "A0A8V0XRI7", "uniprot_id": "A0A8V0XRI7_CHICK", "mass": { "chemical_mass": 95285.0, "monoisotopic_mass": 95285.0 }, "refseq": {}, "gene_names": [ { "name": "ESCO1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A0A8V0XRI7", "id": "A0A8V0XRI7" } ], "protein_names": [ { "name": "Establishment of sister chromatid cohesion N-acetyltransferase 1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A8V0XRI7/entry#names_and_taxonomy", "id": "A0A8V0XRI7" } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Gallus gallus", "taxid": 9031, "evidence": [ { "database": "UniProtKB", "id": "A0A8V0XRI7", "url": "https://www.uniprot.org/uniprot/A0A8V0XRI7" } ], "common_name": "Chicken", "glygen_name": "Chicken", "reference_species": "Gallus gallus [9031]" } ], "gene": [ { "name": "ESCO1", "url": "https://www.uniprot.org/uniprot/A0A8V0XRI7", "locus": { "chromosome": "2", "start_pos": 102028923, "end_pos": 102057315, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSGALG00010005092", "url": "https://www.ensembl.org/id/ENSGALG00010005092" } ] } } ], "crossref": [ { "id": "IPR028005", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028005", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR028009", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028009", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "MKSVHTQ", "url": "https://omabrowser.org/oma/group/MKSVHTQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR45884", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45884", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45884:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45884:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13878", "url": "http://pfam.xfam.org/family/PF13878", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF13880", "url": "http://pfam.xfam.org/family/PF13880", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "45948", "url": "https://www.rhea-db.org/rhea/45948", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A8V0XRI7", "url": "https://www.uniprot.org/uniprot/A0A8V0XRI7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8V0XRI7-1", "url": "https://www.uniprot.org/uniprot/A0A8V0XRI7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAQKRKSALVEPSAKRPRLDKNSRPSSAKKEKEVSDAKHVSNKSNSNQCAVQEKSVLRTSVKSNSVNTNESELGTRMTTRSSGFNSGSKTVPDKKAQQQSKSTKSKEVCQKKPAQEIPKSKCVTAPSESGARRSQRLQQLTHVEEPARSLRSREVKEEKALDVKQSSQAKRPAQNVPAKALKPAGEKAEQKNTKTKSNNAKEDKETRVEVTSSPKEKKCKADKKNDNSKSLQHSVQDSSLCPDDGLEEVKKDQKDPVSPVLSSTKKVKADSPKPNSKTVTKEKQQVHQNIKGSIKPNKVSQPSVSETKVADQPESDVKSKRVSILELCEEIAGEIESDTVEVKKDSPNAECSKTEEEKHAEVQLQQSEMLTQKEPAQSAQCKRFFPSKKGMPVKCTLNGRSNSSNKNSKWTKIKLLKANNMKQTNLNSANAPKLSLLKNFPEVSEASQIATEAQHSKVEGQLPVTRLSENESATCVQDKSDPSSERAGSKEVALEMKQPTKRGVENGLLHNLTKHFSEPRPDENFKLRLESSPESSPVKHLTAPKPSKQLKREPGECDPQVVGLAPKQLTHTSSTNQTSEPENRVPSTNPALTSKCSNLLPSEEHIQKLKEAGKDGEKQLIIDAGQKRFGAISCNICGMLYTASNPEDETQHLLFHNQFISAVKYVGWKKERILAEYPDGRIIMVLPDDPKYALKKVEEIREMVDNDLGFQQAPLMCYSRTKTLLFISNDKKVIGCLIAEHIQWGYRVIEEKVPEISSENEMVIFERQKAWCCSTSPEPAICGISRIWVFSMMRRKKIASRMIECLRSNFIYGSYLSKEEIAFSDPTPDGKLFATQYCGTGQFLVYNFLNGQHQA", "length": 856, "header": "tr|A0A8V0XRI7-1|A0A8V0XRI7_CHICK Isoform 1 of Establishment of sister chromatid cohesion N-acetyltransferase 1 OS=Gallus gallus OX=9031 GN=ESCO1 PE=3 SV=1 CANONICAL=A0A8V0XRI7-1" }, "isoforms": [ { "isoform_ac": "A0A8V0XRI7-1", "url": "https://www.uniprot.org/uniprotkb/A0A8V0XRI7/entry#A0A8V0XRI7-1", "sequence": { "sequence": "MAAQKRKSALVEPSAKRPRLDKNSRPSSAKKEKEVSDAKHVSNKSNSNQCAVQEKSVLRTSVKSNSVNTNESELGTRMTTRSSGFNSGSKTVPDKKAQQQSKSTKSKEVCQKKPAQEIPKSKCVTAPSESGARRSQRLQQLTHVEEPARSLRSREVKEEKALDVKQSSQAKRPAQNVPAKALKPAGEKAEQKNTKTKSNNAKEDKETRVEVTSSPKEKKCKADKKNDNSKSLQHSVQDSSLCPDDGLEEVKKDQKDPVSPVLSSTKKVKADSPKPNSKTVTKEKQQVHQNIKGSIKPNKVSQPSVSETKVADQPESDVKSKRVSILELCEEIAGEIESDTVEVKKDSPNAECSKTEEEKHAEVQLQQSEMLTQKEPAQSAQCKRFFPSKKGMPVKCTLNGRSNSSNKNSKWTKIKLLKANNMKQTNLNSANAPKLSLLKNFPEVSEASQIATEAQHSKVEGQLPVTRLSENESATCVQDKSDPSSERAGSKEVALEMKQPTKRGVENGLLHNLTKHFSEPRPDENFKLRLESSPESSPVKHLTAPKPSKQLKREPGECDPQVVGLAPKQLTHTSSTNQTSEPENRVPSTNPALTSKCSNLLPSEEHIQKLKEAGKDGEKQLIIDAGQKRFGAISCNICGMLYTASNPEDETQHLLFHNQFISAVKYVGWKKERILAEYPDGRIIMVLPDDPKYALKKVEEIREMVDNDLGFQQAPLMCYSRTKTLLFISNDKKVIGCLIAEHIQWGYRVIEEKVPEISSENEMVIFERQKAWCCSTSPEPAICGISRIWVFSMMRRKKIASRMIECLRSNFIYGSYLSKEEIAFSDPTPDGKLFATQYCGTGQFLVYNFLNGQHQA", "length": 856, "header": "tr|A0A8V0XRI7-1|A0A8V0XRI7_CHICK Isoform 1 of Establishment of sister chromatid cohesion N-acetyltransferase 1 OS=Gallus gallus OX=9031 GN=ESCO1 PE=3 SV=1 CANONICAL=A0A8V0XRI7-1" }, "locus": { "chromosome": "2", "start_pos": 102054348, "end_pos": 102029734, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSGALT00010011992.1", "url": "https://www.ensembl.org/id/ENSGALT00010011992.1" }, { "database": "Ensembl Peptide", "id": "ENSGALP00010006703.1", "url": "https://www.ensembl.org/id/ENSGALP00010006703.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A287B1A4-1", "protein_name": "Establishment of sister chromatid cohesion N-acetyltransferase 1", "gene_name": "ESCO1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MMSIQEKSKENSSSAITKSEDKNLETQIQDSQKTPAKKPGPKEAVKSLVNSSNKSRTNQSELGTCMSTRSASSDKKPGKSINKNMVTVKGHSQQESIKKKLSQKKSVHETPKSHEQLNRRSQRLQQLTEVSTRSLRSREIHGQVQAAKQSLPSTRKEHCSNTQSKSNKVKTNQKHVKRKVLEINSDSKEDENSVMNEVINSPKGKKRKIEPQTAYTCSSQCIKESEKCLQKNTRKEETKSVPVTTSEIKRSKKATSVVSKKNEMKKSVHTQVNTSAKPQKSPQPSVPEQSVDNELEQAGKSKRGSILQLCEEIAGEIESDTVEVKKESSQMENIKEEKPTEIKLEETDTERQILHQKETNQDVQCNRFFPSRKTRPVKCILNGINSSTKKNSNWTKIKLSKFNSAQQNKLDTQVSPKLGLLRTNFSLPPLEMHHPVTQSTFLGSKSYDDKKKACQQEEMKEINSEEVNDITVEINKTTKRAPENCHLDNQIKPPPDQPLDNQKKDSFESTPDKNCSLCLESNLGNNPVENTSSVSTLLSQANVDTGENKFPGSAPKQHSIFNNQTSKTSDNRGTPPNHSWPKCNSHLEIRIPRDLKLKEAEKADEKQLIIDAGQKRFGAVSCNVCGMLYTASNPEDETQHLLFHNQFISAVKYVGWKKERILAEYPDGRIIMVLPEDPKYALKKVDEIREMVDNDLGFQQAPLMCYSRTKTLLFISNDKKVVGCLIAEHIQWGYRVIEEKLPVIRSEEEKVRFERQKAWCCSTLPEPAICGISRIWVFSMMRRRKIASRMIECLRSNFIYGSYLSKEEIAFSDPTPDGKLFATQYCGTGQFLVYNFINGQNST", "length": 843 }, "evidence": [ { "id": "A0A8V0XRI7", "url": "https://omabrowser.org/oma/group/A0A8V0XRI7/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q5FWF5-1", "protein_name": "N-acetyltransferase ESCO1", "gene_name": "ESCO1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MMSIQEKSKENSSKVTKKSDDKNSETEIQDSQKNLAKKSGPKETIKSQAKSSSESKINQPELETRMSTRSSKAASNDKATKSINKNTVTVRGYSQESTKKKLSQKKLVHENPKANEQLNRRSQRLQQLTEVSRRSLRSREIQGQVQAVKQSLPPTKKEQCSSTQSKSNKTSQKHVKRKVLEVKSDSKEDENLVINEVINSPKGKKRKVEHQTACACSSQCTQGSEKCPQKTTRRDETKPVPVTSEVKRSKMATSVVPKKNEMKKSVHTQVNTNTTLPKSPQPSVPEQSDNELEQAGKSKRGSILQLCEEIAGEIESDNVEVKKESSQMESVKEEKPTEIKLEETSVERQILHQKETNQDVQCNRFFPSRKTKPVKCILNGINSSAKKNSNWTKIKLSKFNSVQHNKLDSQVSPKLGLLRTSFSPPALEMHHPVTQSTFLGTKLHDRNITCQQEKMKEINSEEVKINDITVEINKTTERAPENCHLANEIKPSDPPLDNQMKHSFDSASNKNFSQCLESKLENSPVENVTAASTLLSQAKIDTGENKFPGSAPQQHSILSNQTSKSSDNRETPRNHSLPKCNSHLEITIPKDLKLKEAEKTDEKQLIIDAGQKRFGAVSCNVCGMLYTASNPEDETQHLLFHNQFISAVKYVGWKKERILAEYPDGRIIMVLPEDPKYALKKVDEIREMVDNDLGFQQAPLMCYSRTKTLLFISNDKKVVGCLIAEHIQWGYRVIEEKLPVIRSEEEKVRFERQKAWCCSTLPEPAICGISRIWVFSMMRRKKIASRMIECLRSNFIYGSYLSKEEIAFSDPTPDGKLFATQYCGTGQFLVYNFINGQNST", "length": 840 }, "evidence": [ { "id": "A0A8V0XRI7", "url": "https://omabrowser.org/oma/group/A0A8V0XRI7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0A8V0XRI7", "url": "https://www.uniprot.org/uniprot/A0A8V0XRI7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "A0A8V0XRI7", "url": "https://www.uniprot.org/uniprot/A0A8V0XRI7" } ], "pmid": "" }, { "name": "acyltransferase activity", "id": "GO:0016746", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016746", "evidence": [ { "database": "UniProtKB", "id": "A0A8V0XRI7", "url": "https://www.uniprot.org/uniprot/A0A8V0XRI7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "cell cycle", "id": "GO:0007049", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007049", "evidence": [ { "database": "UniProtKB", "id": "A0A8V0XRI7", "url": "https://www.uniprot.org/uniprot/A0A8V0XRI7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 403, "end_pos": 405, "annotation": "n_glycosylation_sequon" }, { "start_pos": 43, "end_pos": 45, "annotation": "n_glycosylation_sequon" }, { "start_pos": 471, "end_pos": 473, "annotation": "n_glycosylation_sequon" }, { "start_pos": 512, "end_pos": 514, "annotation": "n_glycosylation_sequon" }, { "start_pos": 577, "end_pos": 579, "annotation": "n_glycosylation_sequon" }, { "start_pos": 70, "end_pos": 72, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "45948", "name": "", "equation": "acetyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-acetyl-L-lysyl-[protein]", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A8V0ZTE0-1", "A0A8V0YX99-1", "A0A8V0X6X9-1", "A0A8V0ZMX8-1", "F1P5A3-1", "A0A8V0ZTT2-1", "A0A8V0X4X8-1", "A0A8V0X4Y2-1", "A0A8V0X885-1", "A0A8V0Z594-1" ], "evidence": [ { "id": "45948", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/45948" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A8V0X4X8", "gene_name": "", "activity": [ { "ec_number": "2.3.1.48", "activity": "acetyl-CoA + L-lysyl-[histone] = CoA + H(+) + N(6)-acetyl-L-lysyl-[histone].", "evidence": [ { "id": "A0A8V0X4X8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8V0X4X8" } ] }, { "ec_number": "2.3.1.48", "activity": "", "evidence": [ { "id": "A0A8V0X4X8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8V0X4X8" } ] } ] }, { "uniprot_ac": "A0A8V0X4Y2", "gene_name": "", "activity": [ { "ec_number": "2.3.1.48", "activity": "acetyl-CoA + L-lysyl-[histone] = CoA + H(+) + N(6)-acetyl-L-lysyl-[histone].", "evidence": [ { "id": "A0A8V0X4Y2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8V0X4Y2" } ] }, { "ec_number": "2.3.1.48", "activity": "", "evidence": [ { "id": "A0A8V0X4Y2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8V0X4Y2" } ] } ] }, { "uniprot_ac": "A0A8V0X6X9", "gene_name": "KAT2B", "activity": [ { "ec_number": "2.3.1.48", "activity": "acetyl-CoA + L-lysyl-[histone] = CoA + H(+) + N(6)-acetyl-L-lysyl-[histone].", "evidence": [ { "id": "A0A8V0X6X9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8V0X6X9" } ] }, { "ec_number": "2.3.1.48", "activity": "", "evidence": [ { "id": "A0A8V0X6X9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8V0X6X9" } ] } ] }, { "uniprot_ac": "A0A8V0X885", "gene_name": "KAT8", "activity": [ { "ec_number": "2.3.1.48", "activity": "acetyl-CoA + L-lysyl-[histone] = CoA + H(+) + N(6)-acetyl-L-lysyl-[histone].", "evidence": [ { "id": "A0A8V0X885", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8V0X885" } ] }, { "ec_number": "2.3.1.48", "activity": "", "evidence": [ { "id": "A0A8V0X885", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8V0X885" } ] } ] }, { "uniprot_ac": "A0A8V0YX99", "gene_name": "NAA60", "activity": [ { "ec_number": "2.3.1.48", "activity": "acetyl-CoA + L-lysyl-[histone] = CoA + H(+) + N(6)-acetyl-L-lysyl-[histone].", "evidence": [ { "id": "A0A8V0YX99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8V0YX99" } ] }, { "ec_number": "2.3.1.259", "activity": "acetyl-CoA + N-terminal L-methionyl-[transmembrane protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-[transmembrane protein].", "evidence": [ { "id": "A0A8V0YX99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8V0YX99" } ] }, { "ec_number": "2.3.1.48", "activity": "", "evidence": [ { "id": "A0A8V0YX99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8V0YX99" } ] }, { "ec_number": "2.3.1.259", "activity": "", "evidence": [ { "id": "A0A8V0YX99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8V0YX99" } ] } ] }, { "uniprot_ac": "A0A8V0Z594", "gene_name": "KAT6A", "activity": [ { "ec_number": "2.3.1.48", "activity": "acetyl-CoA + L-lysyl-[histone] = CoA + H(+) + N(6)-acetyl-L-lysyl-[histone].", "evidence": [ { "id": "A0A8V0Z594", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8V0Z594" } ] }, { "ec_number": "2.3.1.48", "activity": "", "evidence": [ { "id": "A0A8V0Z594", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8V0Z594" } ] } ] }, { "uniprot_ac": "A0A8V0ZMX8", "gene_name": "KAT6B", "activity": [ { "ec_number": "2.3.1.48", "activity": "acetyl-CoA + L-lysyl-[histone] = CoA + H(+) + N(6)-acetyl-L-lysyl-[histone].", "evidence": [ { "id": "A0A8V0ZMX8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8V0ZMX8" } ] }, { "ec_number": "2.3.1.48", "activity": "", "evidence": [ { "id": "A0A8V0ZMX8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8V0ZMX8" } ] } ] }, { "uniprot_ac": "A0A8V0ZTE0", "gene_name": "GTF2B", "activity": [ { "ec_number": "2.3.1.48", "activity": "acetyl-CoA + L-lysyl-[histone] = CoA + H(+) + N(6)-acetyl-L-lysyl-[histone].", "evidence": [ { "id": "A0A8V0ZTE0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8V0ZTE0" } ] }, { "ec_number": "2.3.1.48", "activity": "", "evidence": [ { "id": "A0A8V0ZTE0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8V0ZTE0" } ] } ] }, { "uniprot_ac": "A0A8V0ZTT2", "gene_name": "KAT2A", "activity": [ { "ec_number": "2.3.1.48", "activity": "acetyl-CoA + L-lysyl-[histone] = CoA + H(+) + N(6)-acetyl-L-lysyl-[histone].", "evidence": [ { "id": "A0A8V0ZTT2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8V0ZTT2" } ] }, { "ec_number": "2.3.1.48", "activity": "", "evidence": [ { "id": "A0A8V0ZTT2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8V0ZTT2" } ] } ] }, { "uniprot_ac": "F1P5A3", "gene_name": "HAT1", "activity": [ { "ec_number": "2.3.1.48", "activity": "acetyl-CoA + L-lysyl-[histone] = CoA + H(+) + N(6)-acetyl-L-lysyl-[histone].", "evidence": [ { "id": "F1P5A3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1P5A3" } ] }, { "ec_number": "2.3.1.48", "activity": "", "evidence": [ { "id": "F1P5A3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1P5A3" } ] } ] } ], "biomarkers": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 403, "end_pos": 405 }, { "start_pos": 43, "end_pos": 45 }, { "start_pos": 471, "end_pos": 473 }, { "start_pos": 512, "end_pos": 514 }, { "start_pos": 577, "end_pos": 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