{ "uniprot_canonical_ac": "A0A5G2RBF0-1", "uniprot_ac": "A0A5G2RBF0", "uniprot_id": "A0A5G2RBF0_PIG", "mass": { "chemical_mass": 97899.0, "monoisotopic_mass": 97899.0 }, "refseq": {}, "gene_names": [ { "name": "GSAP", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A0A5G2RBF0", "id": "A0A5G2RBF0" } ], "protein_names": [ { "name": "Gamma-secretase activating protein", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A5G2RBF0/entry#names_and_taxonomy", "id": "A0A5G2RBF0" } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Sus scrofa", "taxid": 9823, "evidence": [ { "database": "UniProtKB", "id": "A0A5G2RBF0", "url": "https://www.uniprot.org/uniprot/A0A5G2RBF0" } ], "common_name": "Pig", "glygen_name": "Pig", "reference_species": "Sus scrofa [9823]" } ], "gene": [ { "name": "GSAP", "url": "https://www.uniprot.org/uniprot/A0A5G2RBF0", "locus": { "chromosome": "9", "start_pos": 102787536, "end_pos": 102694861, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSSSCG00000036113", "url": "https://www.ensembl.org/id/ENSSSCG00000036113" } ] } } ], "crossref": [ { "id": "ENSSSCG00000036113", "url": "https://bgee.org/?page=gene&gene_id=ENSSSCG00000036113", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd23105", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd23105", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR026172", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026172", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR028010", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028010", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "MWDHPIS", "url": "https://omabrowser.org/oma/group/MWDHPIS/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR13630", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13630", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13630:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13630:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF14959", "url": "http://pfam.xfam.org/family/PF14959", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "A0A5G2RBF0", "url": "https://www.uniprot.org/uniprot/A0A5G2RBF0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A5G2RBF0-1", "url": "https://www.uniprot.org/uniprot/A0A5G2RBF0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8D0VQJ4", "url": "https://www.uniprot.org/uniprot/A0A8D0VQJ4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8D0VQJ4-1", "url": "https://www.uniprot.org/uniprot/A0A8D0VQJ4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MALRLVADFDLRKDVLPWLRAASAAAAPGGGGPDILENNYESLRILNIERNGNVIYTYKDDKGNVFFGLYDYQTKQNEHLYTFEKDLQAVSCSVNSERTLLAASLVQAAKEGKRNELQPGSKCLTLLVEIHPVNNVKVLKVDSCIWVQFLHPHVESRPLPVNHLLLISEEKYIEQFHIQVIQEDGNRVVIKNSGHLPRERIAEDFVWAQWDMSEQRLYYIDLKKSKSILKCIQFYADEHFTLMFEAPLDISLSNSGFKLVNFRYDDIQDQEKLSRHPTLCVFTNHTGSLCVCYCPSPDPQEQITYSVFYFHKGHSKTFTAALESVDSGVTKGVTFLNLDYYVAVYLPGHFFHLLNIQHPDLICHSLFLTGNNEVIDLLPHRPLQSLSGSLVLDRCSGKLYRALLNQSYLLEFLWNARLDCEKMALMHCVLSCGRDPRQTEAKIIQWISENISACHSFDLIQEFIIASSYWSIYPETSNMDTLLPYSSLLTWDTEIPGITLVTEEIPLPLMKVHSFKGYWEKLNANLEYVKYSKPHLHYNNSMVRREWLSLISEEKTRKRRSMVYVRNILDNAMKVISNLEARSAEPRLTPLFQEEDNHQRLLMGLMVSELKDHLLRHLQGVEKKKIEQMVLDYVSKLLDLICQILEASWRKHNLHPWVLHFDRRASAAEYAVFHIMTRILEATNSLFLPLPPGFHTLHTILGVRCLPLHNLLHYIDNGVLLLTETAVTRLMKDLDNTEKNEKLKFSIIVRLPPLIGQKICRLWDHPVSSNIISRNHVKHLLQNYNKQPQSCVMDKTSFSVEFLPLNFLIEILTDMESSDPALYAFEGHDNVDAKFVEEAALKHTTALLGL", "length": 850, "header": "tr|A0A5G2RBF0-1|A0A5G2RBF0_PIG Isoform 1 of Gamma-secretase activating protein OS=Sus scrofa OX=9823 GN=GSAP PE=4 SV=1 CANONICAL=A0A5G2RBF0-1" }, "isoforms": [ { "isoform_ac": "A0A5G2RBF0-1", "url": "https://www.uniprot.org/uniprotkb/A0A5G2RBF0/entry#A0A5G2RBF0-1", "sequence": { "sequence": "MALRLVADFDLRKDVLPWLRAASAAAAPGGGGPDILENNYESLRILNIERNGNVIYTYKDDKGNVFFGLYDYQTKQNEHLYTFEKDLQAVSCSVNSERTLLAASLVQAAKEGKRNELQPGSKCLTLLVEIHPVNNVKVLKVDSCIWVQFLHPHVESRPLPVNHLLLISEEKYIEQFHIQVIQEDGNRVVIKNSGHLPRERIAEDFVWAQWDMSEQRLYYIDLKKSKSILKCIQFYADEHFTLMFEAPLDISLSNSGFKLVNFRYDDIQDQEKLSRHPTLCVFTNHTGSLCVCYCPSPDPQEQITYSVFYFHKGHSKTFTAALESVDSGVTKGVTFLNLDYYVAVYLPGHFFHLLNIQHPDLICHSLFLTGNNEVIDLLPHRPLQSLSGSLVLDRCSGKLYRALLNQSYLLEFLWNARLDCEKMALMHCVLSCGRDPRQTEAKIIQWISENISACHSFDLIQEFIIASSYWSIYPETSNMDTLLPYSSLLTWDTEIPGITLVTEEIPLPLMKVHSFKGYWEKLNANLEYVKYSKPHLHYNNSMVRREWLSLISEEKTRKRRSMVYVRNILDNAMKVISNLEARSAEPRLTPLFQEEDNHQRLLMGLMVSELKDHLLRHLQGVEKKKIEQMVLDYVSKLLDLICQILEASWRKHNLHPWVLHFDRRASAAEYAVFHIMTRILEATNSLFLPLPPGFHTLHTILGVRCLPLHNLLHYIDNGVLLLTETAVTRLMKDLDNTEKNEKLKFSIIVRLPPLIGQKICRLWDHPVSSNIISRNHVKHLLQNYNKQPQSCVMDKTSFSVEFLPLNFLIEILTDMESSDPALYAFEGHDNVDAKFVEEAALKHTTALLGL", "length": 850, "header": "tr|A0A5G2RBF0-1|A0A5G2RBF0_PIG Isoform 1 of Gamma-secretase activating protein OS=Sus scrofa OX=9823 GN=GSAP PE=4 SV=1 CANONICAL=A0A5G2RBF0-1" }, "locus": { "chromosome": "9", "start_pos": 102784277, "end_pos": 102694938, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSSSCT00000073342.1", "url": "https://www.ensembl.org/id/ENSSSCT00000073342.1" }, { "database": "Ensembl Peptide", "id": "ENSSSCP00000073655.1", "url": "https://www.ensembl.org/id/ENSSSCP00000073655.1" } ] } }, { "isoform_ac": "A0A8D0VQJ4-1", "url": "https://www.uniprot.org/uniprotkb/A0A5G2RBF0/entry#A0A8D0VQJ4-1", "sequence": { "sequence": "MRKQDLERLTAWKQHSRIPTSVYSGQTWLLFLSPACFHTLHTILGVRCLPLHNLLHYIDNGVLLLTETAVTRLMKDLDNTEKNEKLKFSIIVRLPPLIGQKICRLWDHPVSSNIISRNHVKHLLQNYNKQPQSCVMDKTSFSVEFLPLNFLIEILTDMESSDPALYAFEGHDNVDAKFVEEAALKHTTALLGL", "length": 193, "header": "tr|A0A8D0VQJ4-1|A0A5G2RBF0_PIG Computationally mapped isoform of Gamma-secretase activating protein OS=Sus scrofa OX=9823 GN=GSAP PE=4 SV=1 CANONICAL=A0A5G2RBF0-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "positive regulation of amyloid-beta formation", "id": "GO:1902004", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902004", "evidence": [ { "database": "UniProtKB", "id": "A0A5G2RBF0", "url": "https://www.uniprot.org/uniprot/A0A5G2RBF0" } ], "pmid": "" }, { "name": "regulation of proteolysis", "id": "GO:0030162", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030162", "evidence": [ { "database": "UniProtKB", "id": "A0A5G2RBF0", "url": "https://www.uniprot.org/uniprot/A0A5G2RBF0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "amyloid-beta binding", "id": "GO:0001540", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001540", "evidence": [ { "database": "UniProtKB", "id": "A0A5G2RBF0", "url": "https://www.uniprot.org/uniprot/A0A5G2RBF0" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "trans-Golgi network", "id": "GO:0005802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005802", "evidence": [ { "database": "UniProtKB", "id": "A0A5G2RBF0", "url": "https://www.uniprot.org/uniprot/A0A5G2RBF0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 284, "end_pos": 286, "annotation": "n_glycosylation_sequon" }, { "start_pos": 405, "end_pos": 407, "annotation": "n_glycosylation_sequon" }, { "start_pos": 450, "end_pos": 452, "annotation": "n_glycosylation_sequon" }, { "start_pos": 539, "end_pos": 541, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 284, "end_pos": 286 }, { "start_pos": 405, "end_pos": 407 }, { "start_pos": 450, "end_pos": 452 }, { "start_pos": 539, "end_pos": 541 } ] }, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }