{ "uniprot_canonical_ac": "A0A4X1URL1-1", "uniprot_ac": "A0A4X1URL1", "uniprot_id": "A0A4X1URL1_PIG", "mass": { "chemical_mass": 74311.0, "monoisotopic_mass": 74311.0 }, "refseq": { "ac": "NP_001231347", "name": "delta-like protein 4 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001231347" }, "gene_names": [ { "name": "DLL4", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A0A4X1URL1", "id": "A0A4X1URL1" }, { "name": "DLL4", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001231347", "id": "NP_001231347" } ], "protein_names": [ { "name": "Delta-like protein", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprotkb/A0A4X1URL1/entry#names_and_taxonomy", "id": "A0A4X1URL1" }, { "name": "delta-like protein 4 precursor", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001231347", "id": "NP_001231347" } ], "function": [ { "annotation": "Putative Notch ligand involved in the mediation of Notch signaling.", "evidence": [ { "database": "UniProtKB", "id": "A0A4X1URL1", "url": "https://www.uniprot.org/uniprot/A0A4X1URL1#function" }, { "database": "UniProtKB", "id": "RU280815", "url": "https://www.uniprot.org/uniprot/RU280815#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Sus scrofa", "taxid": 9823, "evidence": [ { "database": "UniProtKB", "id": "A0A4X1URL1", "url": "https://www.uniprot.org/uniprot/A0A4X1URL1" } ], "common_name": "Pig", "glygen_name": "Pig", "reference_species": "Sus scrofa [9823]" } ], "gene": [ { "name": "DLL4", "url": "https://www.uniprot.org/uniprot/A0A4X1URL1", "locus": { "chromosome": "1", "start_pos": 130376721, "end_pos": 130386411, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSSSCG00000004755", "url": "https://www.ensembl.org/id/ENSSSCG00000004755" } ] } } ], "crossref": [ { "id": "ENSSSCG00000004755", "url": "https://bgee.org/?page=gene&gene_id=ENSSSCG00000004755", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00054", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00054", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "100152163", "url": "https://www.ncbi.nlm.nih.gov/gene/100152163", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000152", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000152", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000742", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000742", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001774", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001774", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001881", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001881", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009030", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009030", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011651", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011651", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "ssc:100152163", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+ssc:100152163", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "ICLAGCT", "url": "https://omabrowser.org/oma/group/ICLAGCT/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "5475408at2759", "url": "http://www.orthodb.org/?query=5475408at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24044", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24044", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24044:SF320", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24044:SF320", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00008", "url": "http://pfam.xfam.org/family/PF00008", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF01414", "url": "http://pfam.xfam.org/family/PF01414", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF07657", "url": "http://pfam.xfam.org/family/PF07657", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF21700", "url": "http://pfam.xfam.org/family/PF21700", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "NP_001231347", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001231347", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A4X1URL1", "url": "https://www.uniprot.org/uniprot/A0A4X1URL1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A4X1URL1-1", "url": "https://www.uniprot.org/uniprot/A0A4X1URL1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAASRSPSGWALLLLVALWQQRAAGSGVFQLQLQEFANERGVLASGRRCEPGCRTFFRVCLKHFQAVVSPGPCTFGSVSTPVLGTNSFAVGDDSSGGGRNPLQLPFNFTWPGTFSLIIEAWHAPGDDLRPEALPPDALISKIAIQGSLPVGQKWLLDEQTSPLTRLRYSYRVICSDNYYGDSCSRLCKKRNDHFGHYVCQPDGSLSCLPGWTGEYCEQPVCLSGCHEQNGYCSKPAECICRPGWQGRLCNECIPHNGCRHGTCSTPWQCTCDEGWGGLFCDQDLNYCTHHSPCKNGATCSNSGQRSYTCTCRPGYTGVDCELELSECDSNPCRNGGSCKDQEDGYRCLCPPGYYGLHCEHSTLTCADSPCFNGGSCQERNQGASYACECPPNFTGSNCEKKVDRCTSNPCANGGQCLNRGPNRVCRCRPGFTGAHCELHISDCARSPCAHGGTCHDLETGFVCTCPAGFSGRRCEVRIPTEACASGPCLNGATCYTGLPPDNFVCNCPYGFVGSRCEFPVSMPPSFPWVAVSLGVGLVVVLVVLCMVAVAVRQLRLRRPDDGSREAMNNLSDFQKDNLIPAAQLKNTNQKKELEVDCGLDKSNCGKQQNHTLDYNLAPGPLGRGTLPGKYPHSDKSLGEKAPLRLHSEKPECRISAICSPRDSMYQSVCLISEERNECVIATEV", "length": 685, "header": "tr|A0A4X1URL1-1|A0A4X1URL1_PIG Isoform 1 of Delta-like protein OS=Sus scrofa OX=9823 GN=DLL4 PE=4 SV=1 CANONICAL=A0A4X1URL1-1" }, "isoforms": [ { "isoform_ac": "A0A4X1URL1-1", "url": "https://www.uniprot.org/uniprotkb/A0A4X1URL1/entry#A0A4X1URL1-1", "sequence": { "sequence": "MAAASRSPSGWALLLLVALWQQRAAGSGVFQLQLQEFANERGVLASGRRCEPGCRTFFRVCLKHFQAVVSPGPCTFGSVSTPVLGTNSFAVGDDSSGGGRNPLQLPFNFTWPGTFSLIIEAWHAPGDDLRPEALPPDALISKIAIQGSLPVGQKWLLDEQTSPLTRLRYSYRVICSDNYYGDSCSRLCKKRNDHFGHYVCQPDGSLSCLPGWTGEYCEQPVCLSGCHEQNGYCSKPAECICRPGWQGRLCNECIPHNGCRHGTCSTPWQCTCDEGWGGLFCDQDLNYCTHHSPCKNGATCSNSGQRSYTCTCRPGYTGVDCELELSECDSNPCRNGGSCKDQEDGYRCLCPPGYYGLHCEHSTLTCADSPCFNGGSCQERNQGASYACECPPNFTGSNCEKKVDRCTSNPCANGGQCLNRGPNRVCRCRPGFTGAHCELHISDCARSPCAHGGTCHDLETGFVCTCPAGFSGRRCEVRIPTEACASGPCLNGATCYTGLPPDNFVCNCPYGFVGSRCEFPVSMPPSFPWVAVSLGVGLVVVLVVLCMVAVAVRQLRLRRPDDGSREAMNNLSDFQKDNLIPAAQLKNTNQKKELEVDCGLDKSNCGKQQNHTLDYNLAPGPLGRGTLPGKYPHSDKSLGEKAPLRLHSEKPECRISAICSPRDSMYQSVCLISEERNECVIATEV", "length": 685, "header": "tr|A0A4X1URL1-1|A0A4X1URL1_PIG Isoform 1 of Delta-like protein OS=Sus scrofa OX=9823 GN=DLL4 PE=4 SV=1 CANONICAL=A0A4X1URL1-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "ssc:100152163", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+ssc:100152163", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "D3ZHH1-1", "protein_name": "Delta-like protein 4", "gene_name": "Dll4", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MTPGSRSACRWALLLLAVLWPQQRAAGSGIFQLRLQEFANERGMLANGRPCEPGCRTFFRICLKHYQATFSEGPCTFGNVSTPVLGTNSFVIRDKNSGSGRNPLQLPFNFTWPGTFSLNIQAWHTPGDDLRPETSPGNSLISQIIIQGSLAVGKNWKSDEQNNTLTRLRYSYRVVCSDNYYGDSCSRLCKKRDDHFGHYECQPDGSLSCLPGWTGKYCDQPICLSGCHEQNGYCSKPDECNCRPGWQGPLCNECIPHNGCRHGTCTIPWQCACDEGWGGLFCDQDLNYCTHHSPCKNGSTCSNSGPRGYTCTCLPGYTGEHCELELSKCASNPCRNGGSCKDHENSYHCLCPPGYYGQHCEHSTLTCADSPCFNGGSCRERNQGASYACECPPNFTGSNCEKKVDRCTSNPCANGGQCLNRGPSRTCRCRPGFTGTHCELHISDCARSPCAHGGTCHDLENGPVCTCPAGFSGRRCEVRITNDACASGPCFNGATCYTGLSPNNFVCNCPYGFVGSRCEFPVGLPPSFPWVAVSLGVGLVVLLVLLVMVAVAVRQLRLRRPDDDSREAMNNLSDFQKDNLIPAAQLKNTNQKKELEVDCGLDKSNCGKLQNHTLDYNLAPGFLGRGSTPGKYPHSDKSLGEKVPLRLHSEKPACRISAICSPRDSMYQSVCLISEERNECVIATEV", "length": 686 }, "evidence": [ { "id": "A0A4X1URL1", "url": "https://omabrowser.org/oma/group/A0A4X1URL1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9JI71-1", "protein_name": "Delta-like protein 4", "gene_name": "Dll4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MTPASRSACRWALLLLAVLWPQQRAAGSGIFQLRLQEFVNQRGMLANGQSCEPGCRTFFRICLKHFQATFSEGPCTFGNVSTPVLGTNSFVVRDKNSGSGRNPLQLPFNFTWPGTFSLNIQAWHTPGDDLRPETSPGNSLISQIIIQGSLAVGKIWRTDEQNDTLTRLSYSYRVICSDNYYGESCSRLCKKRDDHFGHYECQPDGSLSCLPGWTGKYCDQPICLSGCHEQNGYCSKPDECICRPGWQGRLCNECIPHNGCRHGTCSIPWQCACDEGWGGLFCDQDLNYCTHHSPCKNGSTCSNSGPKGYTCTCLPGYTGEHCELGLSKCASNPCRNGGSCKDQENSYHCLCPPGYYGQHCEHSTLTCADSPCFNGGSCRERNQGSSYACECPPNFTGSNCEKKVDRCTSNPCANGGQCQNRGPSRTCRCRPGFTGTHCELHISDCARSPCAHGGTCHDLENGPVCTCPAGFSGRRCEVRITHDACASGPCFNGATCYTGLSPNNFVCNCPYGFVGSRCEFPVGLPPSFPWVAVSLGVGLVVLLVLLVMVVVAVRQLRLRRPDDESREAMNNLSDFQKDNLIPAAQLKNTNQKKELEVDCGLDKSNCGKLQNHTLDYNLAPGLLGRGGMPGKYPHSDKSLGEKVPLRLHSEKPECRISAICSPRDSMYQSVCLISEERNECVIATEV", "length": 686 }, "evidence": [ { "id": "A0A4X1URL1", "url": "https://omabrowser.org/oma/group/A0A4X1URL1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9NR61-1", "protein_name": "Delta-like protein 4", "gene_name": "DLL4", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAAASRSASGWALLLLVALWQQRAAGSGVFQLQLQEFINERGVLASGRPCEPGCRTFFRVCLKHFQAVVSPGPCTFGTVSTPVLGTNSFAVRDDSSGGGRNPLQLPFNFTWPGTFSLIIEAWHAPGDDLRPEALPPDALISKIAIQGSLAVGQNWLLDEQTSTLTRLRYSYRVICSDNYYGDNCSRLCKKRNDHFGHYVCQPDGNLSCLPGWTGEYCQQPICLSGCHEQNGYCSKPAECLCRPGWQGRLCNECIPHNGCRHGTCSTPWQCTCDEGWGGLFCDQDLNYCTHHSPCKNGATCSNSGQRSYTCTCRPGYTGVDCELELSECDSNPCRNGGSCKDQEDGYHCLCPPGYYGLHCEHSTLSCADSPCFNGGSCRERNQGANYACECPPNFTGSNCEKKVDRCTSNPCANGGQCLNRGPSRMCRCRPGFTGTYCELHVSDCARNPCAHGGTCHDLENGLMCTCPAGFSGRRCEVRTSIDACASSPCFNRATCYTDLSTDTFVCNCPYGFVGSRCEFPVGLPPSFPWVAVSLGVGLAVLLVLLGMVAVAVRQLRLRRPDDGSREAMNNLSDFQKDNLIPAAQLKNTNQKKELEVDCGLDKSNCGKQQNHTLDYNLAPGPLGRGTMPGKFPHSDKSLGEKAPLRLHSEKPECRISAICSPRDSMYQSVCLISEERNECVIATEV", "length": 685 }, "evidence": [ { "id": "A0A4X1URL1", "url": "https://omabrowser.org/oma/group/A0A4X1URL1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 23, "go_terms": [ { "name": "regulation of neural retina development", "id": "GO:0061074", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061074", "evidence": [ { "database": "UniProtKB", "id": "A0A4X1URL1", "url": "https://www.uniprot.org/uniprot/A0A4X1URL1" } ], "pmid": "" }, { "name": "blood vessel lumenization", "id": "GO:0072554", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072554", "evidence": [ { "database": "UniProtKB", "id": "A0A4X1URL1", "url": "https://www.uniprot.org/uniprot/A0A4X1URL1" } ], "pmid": "" }, { "name": "negative regulation of cell migration involved in sprouting angiogenesis", "id": "GO:0090051", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090051", "evidence": [ { "database": "UniProtKB", "id": "A0A4X1URL1", "url": "https://www.uniprot.org/uniprot/A0A4X1URL1" } ], "pmid": "" }, { "name": "negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis", "id": "GO:1903588", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903588", "evidence": [ { "database": "UniProtKB", "id": "A0A4X1URL1", "url": "https://www.uniprot.org/uniprot/A0A4X1URL1" } ], "pmid": "" }, { "name": "negative regulation of transcription by RNA polymerase II", "id": "GO:0000122", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000122", "evidence": [ { "database": "UniProtKB", "id": "A0A4X1URL1", "url": "https://www.uniprot.org/uniprot/A0A4X1URL1" } ], "pmid": "" }, { "name": "Notch signaling pathway", "id": "GO:0007219", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007219", "evidence": [ { "database": "UniProtKB", "id": "A0A4X1URL1", "url": "https://www.uniprot.org/uniprot/A0A4X1URL1" } ], "pmid": "" }, { "name": "positive regulation of gene expression", "id": "GO:0010628", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010628", "evidence": [ { "database": "UniProtKB", "id": "A0A4X1URL1", "url": "https://www.uniprot.org/uniprot/A0A4X1URL1" } ], "pmid": "" }, { "name": "negative regulation of gene expression", "id": "GO:0010629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010629", "evidence": [ { "database": "UniProtKB", "id": "A0A4X1URL1", "url": "https://www.uniprot.org/uniprot/A0A4X1URL1" } ], "pmid": "" }, { "name": "blood vessel remodeling", "id": "GO:0001974", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001974", "evidence": [ { "database": "UniProtKB", "id": "A0A4X1URL1", "url": "https://www.uniprot.org/uniprot/A0A4X1URL1" } ], "pmid": "" }, { "name": "positive regulation of Notch signaling pathway", "id": "GO:0045747", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045747", "evidence": [ { "database": "UniProtKB", "id": "A0A4X1URL1", "url": "https://www.uniprot.org/uniprot/A0A4X1URL1" } ], "pmid": "" }, { "name": "dorsal aorta morphogenesis", "id": "GO:0035912", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035912", "evidence": [ { "database": "UniProtKB", "id": "A0A4X1URL1", "url": "https://www.uniprot.org/uniprot/A0A4X1URL1" } ], "pmid": "" }, { "name": "branching involved in blood vessel morphogenesis", "id": "GO:0001569", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001569", "evidence": [ { "database": "UniProtKB", "id": "A0A4X1URL1", "url": "https://www.uniprot.org/uniprot/A0A4X1URL1" } ], "pmid": "" }, { "name": "positive regulation of neural precursor cell proliferation", "id": "GO:2000179", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000179", "evidence": [ { "database": "UniProtKB", "id": "A0A4X1URL1", "url": "https://www.uniprot.org/uniprot/A0A4X1URL1" } ], "pmid": "" }, { "name": "cellular response to vascular endothelial growth factor stimulus", "id": "GO:0035924", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035924", "evidence": [ { "database": "UniProtKB", "id": "A0A4X1URL1", "url": "https://www.uniprot.org/uniprot/A0A4X1URL1" } ], "pmid": "" }, { "name": "negative regulation of Notch signaling pathway", "id": "GO:0045746", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045746", "evidence": [ { "database": "UniProtKB", "id": "A0A4X1URL1", "url": "https://www.uniprot.org/uniprot/A0A4X1URL1" } ], "pmid": "" }, { "name": "regulation of neurogenesis", "id": "GO:0050767", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050767", "evidence": [ { "database": "UniProtKB", "id": "A0A4X1URL1", "url": "https://www.uniprot.org/uniprot/A0A4X1URL1" } ], "pmid": "" }, { "name": "ventral spinal cord interneuron fate commitment", "id": "GO:0060579", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060579", "evidence": [ { "database": "UniProtKB", "id": "A0A4X1URL1", "url": "https://www.uniprot.org/uniprot/A0A4X1URL1" } ], "pmid": "" }, { "name": "cellular response to fibroblast growth factor stimulus", "id": "GO:0044344", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044344", "evidence": [ { "database": "UniProtKB", "id": "A0A4X1URL1", "url": "https://www.uniprot.org/uniprot/A0A4X1URL1" } ], "pmid": "" }, { "name": "T cell differentiation", "id": "GO:0030217", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030217", "evidence": [ { "database": "UniProtKB", "id": "A0A4X1URL1", "url": "https://www.uniprot.org/uniprot/A0A4X1URL1" } ], "pmid": "" }, { "name": "pericardium morphogenesis", "id": "GO:0003344", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003344", "evidence": [ { "database": "UniProtKB", "id": "A0A4X1URL1", "url": "https://www.uniprot.org/uniprot/A0A4X1URL1" } ], "pmid": "" }, { "name": "aortic valve morphogenesis", "id": "GO:0003180", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003180", "evidence": [ { "database": "UniProtKB", "id": "A0A4X1URL1", "url": "https://www.uniprot.org/uniprot/A0A4X1URL1" } ], "pmid": "" }, { "name": "ventricular trabecula myocardium morphogenesis", "id": "GO:0003222", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003222", "evidence": [ { "database": "UniProtKB", "id": "A0A4X1URL1", "url": "https://www.uniprot.org/uniprot/A0A4X1URL1" } ], "pmid": "" }, { "name": "cardiac atrium morphogenesis", "id": 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