{
    "uniprot_canonical_ac": "A0A480ECT1-1",
    "uniprot_ac": "A0A480ECT1",
    "uniprot_id": "A0A480ECT1_PIG",
    "mass": {
        "chemical_mass": 112300.0,
        "monoisotopic_mass": 112300.0
    },
    "refseq": {},
    "gene_names": [
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            "name": "FLT3",
            "resource": "UniProtKB",
            "type": "recommended",
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    "disease": [],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
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            "name": "Sus scrofa",
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            "glygen_name": "Pig",
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            "id": "ENSSSCG00000009314",
            "url": "https://bgee.org/?page=gene&gene_id=ENSSSCG00000009314",
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            "id": "IPR013783",
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        {
            "id": "IPR017441",
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        {
            "id": "IPR020635",
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            "id": "IPR036179",
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        {
            "id": "1614410at2759",
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            "database": "OrthoDB",
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        },
        {
            "id": "PTHR24416",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24416",
            "database": "PANTHER",
            "categories": [
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            ]
        },
        {
            "id": "PTHR24416:SF356",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24416:SF356",
            "database": "PANTHER",
            "categories": [
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        },
        {
            "id": "PF00047",
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            "database": "Pfam",
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        },
        {
            "id": "PF07714",
            "url": "http://pfam.xfam.org/family/PF07714",
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            "categories": [
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            ]
        },
        {
            "id": "R-SSC-109704",
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        {
            "id": "R-SSC-1257604",
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        },
        {
            "id": "R-SSC-5673001",
            "url": "https://www.reactome.org/PathwayBrowser/#R-SSC-5673001",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
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        },
        {
            "id": "R-SSC-6811558",
            "url": "https://www.reactome.org/PathwayBrowser/#R-SSC-6811558",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
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        },
        {
            "id": "R-SSC-9607240",
            "url": "https://www.reactome.org/PathwayBrowser/#R-SSC-9607240",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-SSC-9706369",
            "url": "https://www.reactome.org/PathwayBrowser/#R-SSC-9706369",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-SSC-9706374",
            "url": "https://www.reactome.org/PathwayBrowser/#R-SSC-9706374",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "10596",
            "url": "https://www.rhea-db.org/rhea/10596",
            "database": "Rhea",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "A0A480ECT1",
            "url": "https://www.uniprot.org/uniprot/A0A480ECT1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A480ECT1-1",
            "url": "https://www.uniprot.org/uniprot/A0A480ECT1-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MPALARLGGRLPLLVVFSAMIFETITNQDLPVIQCILINHRNNDSSVGTTSSNPMASEAQEDLGCALRPKSKGTVYEAATVEVDVSASITLQVLVATPGNISCLWVFKNSSRNCQPHFDLQNRGVVSMVILKMTETQAGEYQLFIQSEAVNYTVLFTVSIRNTLLYTLRRPYFRKMENQDALVCISEGIPEPTVEWVFCDAQSDSCKGESPAVVTKEESVLHELFGTDIRCCARNELGRECTKLFTIDLNQTPQTTPPQLFLKVGEPLWIRCKAVHVNHGFGLSWELENKALEEGSCFEMSTYSTNRTMIRILFAFVSSVGRNDTGYYTCSSSEHPSKSALVTILEKGFINASKSNEDYEIDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQRGLDDGYSISKFCNHKHQPGQYIFHAENDDAQFTKMFTLNIRRKPQVLAEASASQASCSSDGYPLPSWTWKKCSDKSPNCTEEITEGIWNKKANRKVFGQWISSSTLNMSEAVKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQDNISFYATIGLCLPFIAVLTMLICHKYKKRFRYESQLQMVQVTGSLDNDYFYIDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTHLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDPISGFNGNSFQSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKIGDFGLARDIMSDSNYVIRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPADANFYKLIQSGFKMDQPFYATEEIYFIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNTDGRASERPLYQNRRPFSRQVDSGPPSPQAEDS",
        "length": 990,
        "header": "tr|A0A480ECT1-1|A0A480ECT1_PIG Isoform 1 of receptor protein-tyrosine kinase  OS=Sus scrofa OX=9823 GN=FLT3 PE=3 SV=1 CANONICAL=A0A480ECT1-1"
    },
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        {
            "isoform_ac": "A0A480ECT1-1",
            "url": "https://www.uniprot.org/uniprotkb/A0A480ECT1/entry#A0A480ECT1-1",
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                "length": 990,
                "header": "tr|A0A480ECT1-1|A0A480ECT1_PIG Isoform 1 of receptor protein-tyrosine kinase  OS=Sus scrofa OX=9823 GN=FLT3 PE=3 SV=1 CANONICAL=A0A480ECT1-1"
            },
            "locus": {}
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [],
    "publication": [
        {
            "title": "Genes of the pig, Sus scrofa, reconstructed with EvidentialGene.",
            "journal": "PeerJ",
            "date": "2019",
            "authors": "Gilbert Donald G",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A0A480ECT1",
                    "url": "https://www.uniprot.org/uniprot/A0A480ECT1"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "30723633",
                    "url": "https://glygen.org/publication/PubMed/30723633"
                }
            ]
        }
    ],
    "pathway": [
        {
            "id": "R-SSC-109704",
            "name": "PI3K Cascade",
            "url": "https://www.reactome.org/PathwayBrowser/#R-SSC-109704",
            "resource": "Reactome",
            "description": "PI3K Cascade"
        },
        {
            "id": "R-SSC-1257604",
            "name": "PIP3 activates AKT signaling",
            "url": "https://www.reactome.org/PathwayBrowser/#R-SSC-1257604",
            "resource": "Reactome",
            "description": "PIP3 activates AKT signaling"
        },
        {
            "id": "R-SSC-5673001",
            "name": "RAF/MAP kinase cascade",
            "url": "https://www.reactome.org/PathwayBrowser/#R-SSC-5673001",
            "resource": "Reactome",
            "description": "RAF/MAP kinase cascade"
        },
        {
            "id": "R-SSC-6811558",
            "name": "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling",
            "url": "https://www.reactome.org/PathwayBrowser/#R-SSC-6811558",
            "resource": "Reactome",
            "description": "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"
        },
        {
            "id": "R-SSC-9607240",
            "name": "FLT3 Signaling",
            "url": "https://www.reactome.org/PathwayBrowser/#R-SSC-9607240",
            "resource": "Reactome",
            "description": "FLT3 Signaling"
        },
        {
            "id": "R-SSC-9706369",
            "name": "Negative regulation of FLT3",
            "url": "https://www.reactome.org/PathwayBrowser/#R-SSC-9706369",
            "resource": "Reactome",
            "description": "Negative regulation of FLT3"
        },
        {
            "id": "R-SSC-9706374",
            "name": "FLT3 signaling through SRC family kinases",
            "url": "https://www.reactome.org/PathwayBrowser/#R-SSC-9706374",
            "resource": "Reactome",
            "description": "FLT3 signaling through SRC family kinases"
        }
    ],
    "orthologs": [],
    "go_annotation": {
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            {
                "name": "Molecular Function",
                "total": 5,
                "go_terms": [
                    {
                        "name": "ATP binding",
                        "id": "GO:0005524",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A480ECT1",
                                "url": "https://www.uniprot.org/uniprot/A0A480ECT1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "growth factor binding",
                        "id": "GO:0019838",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019838",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A480ECT1",
                                "url": "https://www.uniprot.org/uniprot/A0A480ECT1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "metal ion binding",
                        "id": "GO:0046872",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A480ECT1",
                                "url": "https://www.uniprot.org/uniprot/A0A480ECT1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "protein self-association",
                        "id": "GO:0043621",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043621",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A480ECT1",
                                "url": "https://www.uniprot.org/uniprot/A0A480ECT1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "transmembrane receptor protein tyrosine kinase activity",
                        "id": "GO:0004714",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004714",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A480ECT1",
                                "url": "https://www.uniprot.org/uniprot/A0A480ECT1"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Cellular Component",
                "total": 3,
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                    {
                        "name": "endoplasmic reticulum",
                        "id": "GO:0005783",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783",
                        "evidence": [
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                                "database": "UniProtKB",
                                "id": "A0A480ECT1",
                                "url": "https://www.uniprot.org/uniprot/A0A480ECT1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "membrane",
                        "id": "GO:0016020",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A480ECT1",
                                "url": "https://www.uniprot.org/uniprot/A0A480ECT1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "receptor complex",
                        "id": "GO:0043235",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043235",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A480ECT1",
                                "url": "https://www.uniprot.org/uniprot/A0A480ECT1"
                            }
                        ],
                        "pmid": ""
                    }
                ]
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            {
                "name": "Biological Process",
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                    {
                        "name": "transmembrane receptor protein tyrosine kinase signaling pathway",
                        "id": "GO:0007169",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007169",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A480ECT1",
                                "url": "https://www.uniprot.org/uniprot/A0A480ECT1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "phosphorylation",
                        "id": "GO:0016310",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016310",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A480ECT1",
                                "url": "https://www.uniprot.org/uniprot/A0A480ECT1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "B cell differentiation",
                        "id": "GO:0030183",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030183",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A480ECT1",
                                "url": "https://www.uniprot.org/uniprot/A0A480ECT1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cytokine-mediated signaling pathway",
                        "id": "GO:0019221",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019221",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A480ECT1",
                                "url": "https://www.uniprot.org/uniprot/A0A480ECT1"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            }
        ]
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            "end_pos": 102,
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            "annotation": "n_glycosylation_sequon"
        },
        {
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            "end_pos": 153,
            "annotation": "n_glycosylation_sequon"
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        {
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            "end_pos": 252,
            "annotation": "n_glycosylation_sequon"
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            "annotation": "n_glycosylation_sequon"
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            "annotation": "n_glycosylation_sequon"
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            "annotation": "n_glycosylation_sequon"
        },
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            "end_pos": 45,
            "annotation": "n_glycosylation_sequon"
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        {
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            "end_pos": 475,
            "annotation": "n_glycosylation_sequon"
        },
        {
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            "annotation": "n_glycosylation_sequon"
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            "annotation": "n_glycosylation_sequon"
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            "annotation": "n_glycosylation_sequon"
        },
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            "end_pos": 736,
            "annotation": "n_glycosylation_sequon"
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            "start_pos": 938,
            "end_pos": 940,
            "annotation": "n_glycosylation_sequon"
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    "interactions": [],
    "reactions": [
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            "id": "10596",
            "name": "",
            "equation": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]",
            "summary": "",
            "cellular_location": "",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [],
            "evidence": [
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                    "database": "Rhea",
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        {
            "id": "R-SSC-109699",
            "name": "PI3K-containing complexes phosphorylate PIP2 to PIP3",
            "equation": "",
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>",
            "cellular_location": "cytosol, endosome membrane, plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [],
            "evidence": [
                {
                    "id": "R-SSC-109699",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-SSC-109699"
                }
            ]
        },
        {
            "id": "R-SSC-2316434",
            "name": "PI3K phosphorylates PIP2 to PIP3",
            "equation": "",
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>",
            "cellular_location": "cytosol, plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [],
            "evidence": [
                {
                    "id": "R-SSC-2316434",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-SSC-2316434"
                }
            ]
        },
        {
            "id": "R-SSC-5672965",
            "name": "RAS GEFs promote RAS nucleotide exchange",
            "equation": "",
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>",
            "cellular_location": "plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [],
            "evidence": [
                {
                    "id": "R-SSC-5672965",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-SSC-5672965"
                }
            ]
        },
        {
            "id": "R-SSC-6786789",
            "name": "FLT3LG dimer binds FLT3",
            "equation": "",
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>",
            "cellular_location": "extracellular region, plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [],
            "evidence": [
                {
                    "id": "R-SSC-6786789",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-SSC-6786789"
                }
            ]
        },
        {
            "id": "R-SSC-8854736",
            "name": "FLT3LG dimer:FLT3 binds FLT3",
            "equation": "",
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>",
            "cellular_location": "extracellular region, plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [],
            "evidence": [
                {
                    "id": "R-SSC-8854736",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-SSC-8854736"
                }
            ]
        },
        {
            "id": "R-SSC-9604767",
            "name": "FLT3LG dimer:FLT3 dimer autophosphorylates",
            "equation": "",
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>",
            "cellular_location": "plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [],
            "evidence": [
                {
                    "id": "R-SSC-9604767",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-SSC-9604767"
                }
            ]
        },
        {
            "id": "R-SSC-9607301",
            "name": "Active FLT3:GRB2 binds SOS1",
            "equation": "",
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>",
            "cellular_location": "cytosol, plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [],
            "evidence": [
                {
                    "id": "R-SSC-9607301",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-SSC-9607301"
                }
            ]
        },
        {
            "id": "R-SSC-9607304",
            "name": "SOS1-mediated nucleotide exchange of RAS downstream of FLT3",
            "equation": "",
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>",
            "cellular_location": "cytosol, plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [],
            "evidence": [
                {
                    "id": "R-SSC-9607304",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-SSC-9607304"
                }
            ]
        },
        {
            "id": "R-SSC-9698170",
            "name": "Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA",
            "equation": "",
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>",
            "cellular_location": "cytosol, plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [],
            "evidence": [
                {
                    "id": "R-SSC-9698170",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-SSC-9698170"
                }
            ]
        },
        {
            "id": "R-SSC-9699578",
            "name": "Active FLT3 phosphorylates CDKN1B",
            "equation": "",
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>",
            "cellular_location": "cytosol, plasma membrane",
            "input_participant_list": [
                "R-SSC-198622"
            ],
            "output_participant_list": [
                "R-SSC-8848438"
            ],
            "enzyme_list": [],
            "evidence": [
                {
                    "id": "R-SSC-9699578",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-SSC-9699578"
                }
            ]
        },
        {
            "id": "R-SSC-9706287",
            "name": "Active FLT3 binds to ABL2",
            "equation": "",
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>",
            "cellular_location": "cytosol, plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [],
            "evidence": [
                {
                    "id": "R-SSC-9706287",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-SSC-9706287"
                }
            ]
        },
        {
            "id": "R-SSC-9706293",
            "name": "Active FLT3 binds to CBL",
            "equation": "",
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>",
            "cellular_location": "cytosol, plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [],
            "evidence": [
                {
                    "id": "R-SSC-9706293",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-SSC-9706293"
                }
            ]
        },
        {
            "id": "R-SSC-9706298",
            "name": "Active FLT3 binds to CSK",
            "equation": "",
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>",
            "cellular_location": "cytosol, plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [],
            "evidence": [
                {
                    "id": "R-SSC-9706298",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-SSC-9706298"
                }
            ]
        },
        {
            "id": "R-SSC-9706304",
            "name": "Active FLT3 binds to GRAP2",
            "equation": "",
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>",
            "cellular_location": "cytosol, plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [],
            "evidence": [
                {
                    "id": "R-SSC-9706304",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-SSC-9706304"
                }
            ]
        },
        {
            "id": "R-SSC-9706308",
            "name": "Active FLT3 binds to GRB10",
            "equation": "",
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>",
            "cellular_location": "cytosol, plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [],
            "evidence": [
                {
                    "id": "R-SSC-9706308",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-SSC-9706308"
                }
            ]
        },
        {
            "id": "R-SSC-9706312",
            "name": "Active FLT3 binds to LCK",
            "equation": "",
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>",
            "cellular_location": "cytosol, plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [],
            "evidence": [
                {
                    "id": "R-SSC-9706312",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-SSC-9706312"
                }
            ]
        },
        {
            "id": "R-SSC-9706315",
            "name": "Active FLT3 binds to SH2B3",
            "equation": "",
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>",
            "cellular_location": "cytosol, plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [],
            "evidence": [
                {
                    "id": "R-SSC-9706315",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-SSC-9706315"
                }
            ]
        },
        {
            "id": "R-SSC-9706319",
            "name": "Active FLT3 binds to SLA",
            "equation": "",
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>",
            "cellular_location": "cytosol, plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [],
            "evidence": [
                {
                    "id": "R-SSC-9706319",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-SSC-9706319"
                }
            ]
        },
        {
            "id": "R-SSC-9706328",
            "name": "Active FLT3 binds to SOCS2",
            "equation": "",
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>",
            "cellular_location": "cytosol, plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [],
            "evidence": [
                {
                    "id": "R-SSC-9706328",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-SSC-9706328"
                }
            ]
        },
        {
            "id": "R-SSC-9706330",
            "name": "Active FLT3 binds to SOCS6",
            "equation": "",
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>",
            "cellular_location": "cytosol, plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [],
            "evidence": [
                {
                    "id": "R-SSC-9706330",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-SSC-9706330"
                }
            ]
        },
        {
            "id": "R-SSC-9706336",
            "name": "Active FLT3 binds to SYK",
            "equation": "",
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>",
            "cellular_location": "cytosol, plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [],
            "evidence": [
                {
                    "id": "R-SSC-9706336",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-SSC-9706336"
                }
            ]
        },
        {
            "id": "R-SSC-9706340",
            "name": "Active FLT3:p-Y-GRB10 binds PIK3R1",
            "equation": "",
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>",
            "cellular_location": "cytosol, plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [],
            "evidence": [
                {
                    "id": "R-SSC-9706340",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-SSC-9706340"
                }
            ]
        },
        {
            "id": "R-SSC-9706344",
            "name": "FLT3 phosphorylates GRB10",
            "equation": "",
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>",
            "cellular_location": "cytosol, plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [],
            "evidence": [
                {
                    "id": "R-SSC-9706344",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-SSC-9706344"
                }
            ]
        },
        {
            "id": "R-SSC-9706345",
            "name": "Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA",
            "equation": "",
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>",
            "cellular_location": "cytosol, plasma membrane",
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            "enzyme_list": [],
            "evidence": [
                {
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                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-SSC-9706345"
                }
            ]
        },
        {
            "id": "R-SSC-9706350",
            "name": "FLT3 phosphorylates CBL",
            "equation": "",
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>",
            "cellular_location": "plasma membrane",
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            "enzyme_list": [],
            "evidence": [
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                    "id": "R-SSC-9706350",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-SSC-9706350"
                }
            ]
        },
        {
            "id": "R-SSC-9706354",
            "name": "Ubiquitination of FLT3",
            "equation": "",
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>",
            "cellular_location": "plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [],
            "evidence": [
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                    "id": "R-SSC-9706354",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-SSC-9706354"
                }
            ]
        },
        {
            "id": "R-SSC-9706364",
            "name": "Internalization of ubiquitinated FLT3",
            "equation": "",
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>",
            "cellular_location": "endosome membrane, plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [],
            "evidence": [
                {
                    "id": "R-SSC-9706364",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-SSC-9706364"
                }
            ]
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