{
    "uniprot_canonical_ac": "A0A287ASV6-1",
    "uniprot_ac": "A0A287ASV6",
    "uniprot_id": "A0A287ASV6_PIG",
    "mass": {
        "chemical_mass": 34628.0,
        "monoisotopic_mass": 34628.0
    },
    "refseq": {
        "ac": "XP_003358659",
        "name": "E3 ubiquitin-protein ligase SIAH2",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003358659"
    },
    "gene_names": [
        {
            "name": "SIAH2",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/A0A287ASV6",
            "id": "A0A287ASV6"
        },
        {
            "name": "SIAH2",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003358659",
            "id": "XP_003358659"
        }
    ],
    "protein_names": [
        {
            "name": "E3 ubiquitin-protein ligase",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprotkb/A0A287ASV6/entry#names_and_taxonomy",
            "id": "A0A287ASV6"
        },
        {
            "name": "2.3.2.27",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprotkb/A0A287ASV6/entry#names_and_taxonomy",
            "id": "A0A287ASV6"
        },
        {
            "name": "E3 ubiquitin-protein ligase SIAH2",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003358659",
            "id": "XP_003358659"
        }
    ],
    "function": [
        {
            "annotation": "E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A0A287ASV6",
                    "url": "https://www.uniprot.org/uniprot/A0A287ASV6#function"
                },
                {
                    "database": "UniProtKB",
                    "id": "RU201113",
                    "url": "https://www.uniprot.org/uniprot/RU201113#function"
                }
            ]
        }
    ],
    "disease": [],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Sus scrofa",
            "taxid": 9823,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A0A287ASV6",
                    "url": "https://www.uniprot.org/uniprot/A0A287ASV6"
                }
            ],
            "common_name": "Pig",
            "glygen_name": "Pig",
            "reference_species": "Sus scrofa [9823]"
        }
    ],
    "gene": [
        {
            "name": "SIAH2",
            "url": "https://www.uniprot.org/uniprot/A0A287ASV6",
            "locus": {
                "chromosome": "13",
                "start_pos": 90949021,
                "end_pos": 90971411,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSSSCG00000031388",
                        "url": "https://www.ensembl.org/id/ENSSSCG00000031388"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSSSCG00000031388",
            "url": "https://bgee.org/?page=gene&gene_id=ENSSSCG00000031388",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "cd03829",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03829",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "cd16752",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16752",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "100622531",
            "url": "https://www.ncbi.nlm.nih.gov/gene/100622531",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "IPR001841",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001841",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR004162",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR004162",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR008974",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR008974",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR013010",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR013010",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR013083",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR013083",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR018121",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR018121",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR049548",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR049548",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "ssc:100622531",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+ssc:100622531",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "AGHLVCK",
            "url": "https://omabrowser.org/oma/group/AGHLVCK/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "222086at2759",
            "url": "http://www.orthodb.org/?query=222086at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR45877",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45877",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR45877:SF4",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45877:SF4",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF03145",
            "url": "http://pfam.xfam.org/family/PF03145",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF21361",
            "url": "http://pfam.xfam.org/family/PF21361",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF21362",
            "url": "http://pfam.xfam.org/family/PF21362",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-SSC-5689880",
            "url": "https://www.reactome.org/PathwayBrowser/#R-SSC-5689880",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-SSC-983168",
            "url": "https://www.reactome.org/PathwayBrowser/#R-SSC-983168",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "XP_003358659",
            "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003358659",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A287ASV6",
            "url": "https://www.uniprot.org/uniprot/A0A287ASV6",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A287ASV6-1",
            "url": "https://www.uniprot.org/uniprot/A0A287ASV6-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MSRPSSTGPSANKPCNKQPPPQPQHAPSPAAPPAAATISAAGPGSSAVPAAAAVISGPGGGGGAGPVSPQHHELTSLFECPVCFDYVLPPILQCQAGHLVCNQCRQKLSCCPTCRGALTPSIRNLAMEKVASAVLFPCKYATTGCSLTLHHTEKPEHEDICEYRPYSCPCPGASCKWQGSLEAVMSHLMHAHKSITTLQGEDIVFLATDINLPGAVDWVMMQSCFGHHFMLVLEKQEKYEGHQQFFAIVLLIGTRKQAENFAYRLELNGNRRRLTWEATPRSIHDGVSAAIMNSDCLVFDTAIAHLFADNGNLGINVTISTCCP",
        "length": 324,
        "header": "tr|A0A287ASV6-1|A0A287ASV6_PIG Isoform 1 of E3 ubiquitin-protein ligase  OS=Sus scrofa OX=9823 GN=SIAH2 PE=3 SV=1 CANONICAL=A0A287ASV6-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A0A287ASV6-1",
            "url": "https://www.uniprot.org/uniprotkb/A0A287ASV6/entry#A0A287ASV6-1",
            "sequence": {
                "sequence": "MSRPSSTGPSANKPCNKQPPPQPQHAPSPAAPPAAATISAAGPGSSAVPAAAAVISGPGGGGGAGPVSPQHHELTSLFECPVCFDYVLPPILQCQAGHLVCNQCRQKLSCCPTCRGALTPSIRNLAMEKVASAVLFPCKYATTGCSLTLHHTEKPEHEDICEYRPYSCPCPGASCKWQGSLEAVMSHLMHAHKSITTLQGEDIVFLATDINLPGAVDWVMMQSCFGHHFMLVLEKQEKYEGHQQFFAIVLLIGTRKQAENFAYRLELNGNRRRLTWEATPRSIHDGVSAAIMNSDCLVFDTAIAHLFADNGNLGINVTISTCCP",
                "length": 324,
                "header": "tr|A0A287ASV6-1|A0A287ASV6_PIG Isoform 1 of E3 ubiquitin-protein ligase  OS=Sus scrofa OX=9823 GN=SIAH2 PE=3 SV=1 CANONICAL=A0A287ASV6-1"
            },
            "locus": {}
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [],
    "publication": [
        {
            "title": "Genes of the pig, Sus scrofa, reconstructed with EvidentialGene.",
            "journal": "PeerJ",
            "date": "2019",
            "authors": "Gilbert Donald G",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A0A287ASV6",
                    "url": "https://www.uniprot.org/uniprot/A0A287ASV6"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "30723633",
                    "url": "https://glygen.org/publication/PubMed/30723633"
                }
            ]
        }
    ],
    "pathway": [
        {
            "id": "ssc:100622531",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+ssc:100622531",
            "resource": "KEGG Pathway"
        },
        {
            "id": "R-SSC-5689880",
            "name": "Ub-specific processing proteases",
            "url": "https://www.reactome.org/PathwayBrowser/#R-SSC-5689880",
            "resource": "Reactome",
            "description": "Ub-specific processing proteases"
        },
        {
            "id": "R-SSC-983168",
            "name": "Antigen processing: Ubiquitination & Proteasome degradation",
            "url": "https://www.reactome.org/PathwayBrowser/#R-SSC-983168",
            "resource": "Reactome",
            "description": "Antigen processing: Ubiquitination & Proteasome degradation"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "E1C3Q9-1",
            "protein_name": "E3 ubiquitin-protein ligase",
            "gene_name": "SIAH2",
            "tax_id": 9031,
            "organism": "Gallus gallus",
            "sequence": {
                "sequence": "MSRPSSAGPGASKPCGKQPPPHASAPAAAAPAPAAATIAASGAGSSAVPAAAAVLSGPGGPVSPQHHELTSLFECPVCFDYVLPPILQCQAGHLVCKQCRQKLSLCPTCRGSLTPSIRNLAMEKVASAVLFPCKYATTGCSLTLHHTEKPEHEDICEYRPYSCPCPGATCKWQGSLEAVMSHLMHAHKSITTLQGEDIVFLATDINLPGAVDWVMMQSCFGHHFMLVLEKQEKYEGHQQFFAIVLLIGTRKQAENFAYRLELNGNRRRLTWEATPRSIHDGVNAAIVNSDCLVFDTAIAHLFADNGNLGINVTISTCCP",
                "length": 319
            },
            "evidence": [
                {
                    "id": "A0A287ASV6",
                    "url": "https://omabrowser.org/oma/group/A0A287ASV6/",
                    "database": "OMA"
                }
            ],
            "glygen_name": "Chicken",
            "common_name": "Chicken"
        },
        {
            "uniprot_canonical_ac": "O43255-1",
            "protein_name": "E3 ubiquitin-protein ligase SIAH2",
            "gene_name": "SIAH2",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MSRPSSTGPSANKPCSKQPPPQPQHTPSPAAPPAAATISAAGPGSSAVPAAAAVISGPGGGGGAGPVSPQHHELTSLFECPVCFDYVLPPILQCQAGHLVCNQCRQKLSCCPTCRGALTPSIRNLAMEKVASAVLFPCKYATTGCSLTLHHTEKPEHEDICEYRPYSCPCPGASCKWQGSLEAVMSHLMHAHKSITTLQGEDIVFLATDINLPGAVDWVMMQSCFGHHFMLVLEKQEKYEGHQQFFAIVLLIGTRKQAENFAYRLELNGNRRRLTWEATPRSIHDGVAAAIMNSDCLVFDTAIAHLFADNGNLGINVTISTCCP",
                "length": 324
            },
            "evidence": [
                {
                    "id": "A0A287ASV6",
                    "url": "https://omabrowser.org/oma/group/A0A287ASV6/",
                    "database": "OMA"
                }
            ],
            "glygen_name": "Human",
            "common_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q06986-1",
            "protein_name": "E3 ubiquitin-protein ligase SIAH2",
            "gene_name": "Siah2",
            "tax_id": 10090,
            "organism": "Mus musculus",
            "sequence": {
                "sequence": "MSRPSSTGPSANKPCSKQPPPPQTPHAPSPAAPPAAATISAAGPGSSAVPAAAAVISGPGAGGGADPVSPQHHELTSLFECPVCFDYVLPPILQCQAGHLVCNQCRQKLSCCPTCRGALTPSIRNLAMEKVASAVLFPCKYATTGCSLTLHHTEKPEHEDICEYRPYSCPCPGASCKWQGSLEAVMSHLMHAHKSITTLQGEDIVFLATDINLPGAVDWVMMQSCFGHHFMLVLEKQEKYEGHQQFFAIVLLIGTRKQAENFAYRLELNGNRRRLTWEATPRSIHDGVAAAIMNSDCLVFDTAIAHLFADNGNLGINVTISTCCQ",
                "length": 325
            },
            "evidence": [
                {
                    "id": "A0A287ASV6",
                    "url": "https://omabrowser.org/oma/group/A0A287ASV6/",
                    "database": "OMA"
                }
            ],
            "glygen_name": "Mouse",
            "common_name": "Mouse"
        },
        {
            "uniprot_canonical_ac": "Q8R4T2-1",
            "protein_name": "E3 ubiquitin-protein ligase SIAH2",
            "gene_name": "Siah2",
            "tax_id": 10116,
            "organism": "Rattus norvegicus",
            "sequence": {
                "sequence": "MSRPSSTGPSANKPCSKQPPPPQTPHAPSPAAPPAAATISAAGPGSSAVPAAAAVISGPGAGGGAGPVSPQHHELTSLFECPVCFDYVLPPILQCQAGHLVCNQCRQKLSCCPTCRGALTPSIRNLAMEKVASAVLFPCKYATTGCSLTLHHTEKPEHEDICEYRPYSCPCPGASCKWQGSLEAVMSHLMHAHKSITTLQGEDIVFLATDINLPGAVDWVMMQSCFGHHFMLVLEKQEKYEGHQQFFAIVLLIGTRKQAENFAYRLELNGNRRRLTWEATPRSIHDGVAAAIMNSDCLVFDTAIAHLFADNGNLGINVTISTCCQ",
                "length": 325
            },
            "evidence": [
                {
                    "id": "A0A287ASV6",
                    "url": "https://omabrowser.org/oma/group/A0A287ASV6/",
                    "database": "OMA"
                }
            ],
            "glygen_name": "Rat",
            "common_name": "Rat"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Cellular Component",
                "total": 3,
                "go_terms": [
                    {
                        "name": "nucleoplasm",
                        "id": "GO:0005654",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A287ASV6",
                                "url": "https://www.uniprot.org/uniprot/A0A287ASV6"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cytoplasm",
                        "id": "GO:0005737",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A287ASV6",
                                "url": "https://www.uniprot.org/uniprot/A0A287ASV6"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cytosol",
                        "id": "GO:0005829",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A287ASV6",
                                "url": "https://www.uniprot.org/uniprot/A0A287ASV6"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Molecular Function",
                "total": 3,
                "go_terms": [
                    {
                        "name": "zinc ion binding",
                        "id": "GO:0008270",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A287ASV6",
                                "url": "https://www.uniprot.org/uniprot/A0A287ASV6"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "ubiquitin protein ligase activity",
                        "id": "GO:0061630",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061630",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A287ASV6",
                                "url": "https://www.uniprot.org/uniprot/A0A287ASV6"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "ubiquitin conjugating enzyme binding",
                        "id": "GO:0031624",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031624",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A287ASV6",
                                "url": "https://www.uniprot.org/uniprot/A0A287ASV6"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Biological Process",
                "total": 7,
                "go_terms": [
                    {
                        "name": "negative regulation of canonical Wnt signaling pathway",
                        "id": "GO:0090090",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090090",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A287ASV6",
                                "url": "https://www.uniprot.org/uniprot/A0A287ASV6"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "proteasome-mediated ubiquitin-dependent protein catabolic process",
                        "id": "GO:0043161",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043161",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A287ASV6",
                                "url": "https://www.uniprot.org/uniprot/A0A287ASV6"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "protein ubiquitination",
                        "id": "GO:0016567",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016567",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A287ASV6",
                                "url": "https://www.uniprot.org/uniprot/A0A287ASV6"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "regulation of circadian rhythm",
                        "id": "GO:0042752",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042752",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A287ASV6",
                                "url": "https://www.uniprot.org/uniprot/A0A287ASV6"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "rhythmic process",
                        "id": "GO:0048511",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048511",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A287ASV6",
                                "url": "https://www.uniprot.org/uniprot/A0A287ASV6"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "canonical Wnt signaling pathway",
                        "id": "GO:0060070",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060070",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A287ASV6",
                                "url": "https://www.uniprot.org/uniprot/A0A287ASV6"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "negative regulation of extrinsic apoptotic signaling pathway",
                        "id": "GO:2001237",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2001237",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A287ASV6",
                                "url": "https://www.uniprot.org/uniprot/A0A287ASV6"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            }
        ]
    },
    "pro_annotation": [],
    "site_annotation": [
        {
            "start_pos": 316,
            "end_pos": 318,
            "annotation": "n_glycosylation_sequon"
        }
    ],
    "ptm_annotation": [],
    "interactions": [],
    "reactions": [
        {
            "id": "R-SSC-6781899",
            "name": "USP13 binds SIAH2",
            "equation": "",
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>",
            "cellular_location": "cytosol",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [],
            "evidence": [
                {
                    "id": "R-SSC-6781899",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-SSC-6781899"
                }
            ]
        },
        {
            "id": "R-SSC-983140",
            "name": "Transfer of Ub from E2 to substrate and release of E2",
            "equation": "",
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>",
            "cellular_location": "cytosol",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [],
            "evidence": [
                {
                    "id": "R-SSC-983140",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-SSC-983140"
                }
            ]
        },
        {
            "id": "R-SSC-983147",
            "name": "Release of E3 from polyubiquitinated substrate",
            "equation": "",
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>",
            "cellular_location": "cytosol",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [],
            "evidence": [
                {
                    "id": "R-SSC-983147",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-SSC-983147"
                }
            ]
        },
        {
            "id": "R-SSC-983156",
            "name": "Polyubiquitination of substrate",
            "equation": "",
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>",
            "cellular_location": "cytosol",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [],
            "evidence": [
                {
                    "id": "R-SSC-983156",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-SSC-983156"
                }
            ]
        },
        {
            "id": "R-SSC-983157",
            "name": "Interaction of E3 with substrate and E2-Ub complex",
            "equation": "",
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>",
            "cellular_location": "cytosol",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [],
            "evidence": [
                {
                    "id": "R-SSC-983157",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-SSC-983157"
                }
            ]
        }
    ],
    "reaction_participants": [],
    "reaction_enzymes": [],
    "biomarkers": [],
    "synthesized_glycans": [],
    "enzyme_annotation": [],
    "cluster_types": [
        {
            "name": "homologset.oma",
            "label": "OMA Homologs"
        }
    ],
    "sequence_features": {
        "n_linked_sites": [],
        "o_linked_sites": [],
        "snv_sites": [],
        "glycation_sites": [],
        "phosphorylation_sites": [],
        "sequon_annotation_sites": [
            {
                "start_pos": 316,
                "end_pos": 318
            }
        ]
    },
    "section_stats": [
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            ],
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        {
            "table_id": "snv_disease",
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