{ "bcoid": "GLY_000325", "title": "Rat Protein Enzyme Annotation (UniProtKB)", "description": "The Rat Protein Enzyme Annotation (UniProtKB) dataset contains rat [taxid:10116] enzyme annotations for ...", "filename": "rat_protein_enzyme_annotation_uniprotkb.csv", "filetype": "csv", "categories": { "species": [ "Rattus norvegicus" ], "molecule": [ "Protein" ], "tag": [ "enzyme annotation" ], "file_type": [ "csv" ], "status": [ "Reviewed" ], "scope": [ "internal" ] }, "minitable": { "content": [ [ "F1LQQ5-1...", "3.1.3.48..." ], [ "F1LQQ5-1...", "3.1.3.48..." ] ], "headers": [ "uniprotkb_ca...", "enzyme_ec..." ], "colwidth": [ "40%", "20%" ] }, "sampledata": { "type": "table", "data": [ [ { "type": "string", "label": "uniprotkb_canonical_ac" }, { "type": "string", "label": "enzyme_ec" }, { "type": "string", "label": "enzyme_activity" } ], [ "F1LQQ5-1", "3.1.3.48", "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate." ], [ "F1LQQ5-1", "3.1.3.48", "" ], [ "Q5RJK3-1", "2.1.1.221", "guanosine(9) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)-methylguanosine(9) in tRNA + S-adenosyl-L-homocysteine." ], [ "Q5RJK3-1", "2.1.1.221", "" ], [ "P30349-1", "3.3.2.6", "H2O + leukotriene A4 = leukotriene B4." ], [ "P30349-1", "3.4.11.4", "Release of the N-terminal residue from a tripeptide." ], [ "P30349-1", "3.3.2.6", "" ], [ "Q6MG55-1", "3.1.1.23", "Hydrolyzes glycerol monoesters of long-chain fatty acids." ], [ "Q6MG55-1", "3.1.-.-", "" ], [ "Q5I0C5-1", "2.1.2.9", "(6S)-10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = (6S)-5,6,7,8-tetrahydrofolate + H(+) + N-formyl-L-methionyl-tRNA(fMet)." ], [ "Q5I0C5-1", "2.1.2.9", "" ], [ "Q62844-1", "2.7.10.2", "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]." ], [ "Q62844-1", "2.7.10.2", "" ], [ "Q5RJZ1-1", "3.6.4.12", "ATP + H2O = ADP + H(+) + phosphate." ], [ "Q5RJZ1-1", "3.6.4.12", "" ], [ "P11980-1", "2.7.1.40", "CTP + pyruvate = CDP + H(+) + phosphoenolpyruvate." ], [ "P11980-1", "2.7.1.40", "" ], [ "Q9WUD9-1", "2.7.10.2", "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]." ], [ "Q9WUD9-1", "2.7.10.2", "" ], [ "D3ZFU9-1", "2.7.11.18", "ATP + L-seryl-[myosin light chain] = ADP + H(+) + O-phospho-L-seryl-[myosin light chain]." ], [ "D3ZFU9-1", "2.7.11.18", "" ], [ "P20717-1", "3.5.3.15", "H2O + L-arginyl-[protein] = L-citrullyl-[protein] + NH4(+)." ], [ "P20717-1", "3.5.3.15", "" ], [ "O08874-1", "2.7.11.13", "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]." ], [ "O08874-1", "2.7.11.13", "" ], [ "Q9QYG8-1", "2.7.1.48", "cytidine + GTP = CMP + GDP + H(+)." ], [ "Q9QYG8-1", "2.7.1.48", "" ], [ "A0A0G2JTB2-1", "2.4.1.18", "Transfers a segment of a (1->4)-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain." ], [ "A0A0G2JTB2-1", "2.4.1.18", "" ], [ "A0A0G2KA92-1", "3.6.4.12", "ATP + H2O = ADP + H(+) + phosphate." ], [ "A0A0G2KA92-1", "3.6.4.12", "" ], [ "D4A830-1", "3.6.1.1", "diphosphate + H2O = H(+) + 2 phosphate." ], [ "D4A830-1", "3.6.1.1", "" ], [ "M0RCZ9-1", "5.2.1.8", "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)." ], [ "M0RCZ9-1", "5.2.1.8", "" ], [ "Q66H84-1", "2.7.11.1", "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]." ], [ "Q66H84-1", "2.7.11.1", "" ], [ "Q5BK16-1", "3.1.11.2", "Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates." ], [ "Q5BK16-1", "3.1.11.2", "" ], [ "Q5BK17-1", "1.21.1.1", "2 iodide + L-tyrosine + 2 NADP(+) = 3,5-diiodo-L-tyrosine + H(+) + 2 NADPH." ], [ "Q5BK17-1", "1.21.1.1", "" ], [ "P56574-1", "1.1.1.42", "D-threo-isocitrate + NADP(+) = 2-oxoglutarate + CO2 + NADPH." ], [ "P56574-1", "1.1.1.42", "" ], [ "Q5BK10-1", "3.4.22.-", "" ], [ "P48965-1", "3.1.3.48", "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate." ], [ "P48965-1", "3.1.3.48", "" ], [ "P48966-1", "3.1.3.48", "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate." ], [ "P48966-1", "3.1.3.48", "" ], [ "Q6P7Q4-1", "4.4.1.5", "(R)-S-lactoylglutathione = glutathione + methylglyoxal." ], [ "Q6P7Q4-1", "4.4.1.5", "" ], [ "Q14U74-1", "2.4.1.109", "a dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a dolichyl phosphate + H(+)." ], [ "Q14U74-1", "2.4.1.109", "" ], [ "Q62940-1", "2.3.2.26", "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine." ], [ "Q62940-1", "2.3.2.26", "" ], [ "P18298-1", "2.5.1.6", "ATP + H2O + L-methionine = diphosphate + phosphate + S-adenosyl-L-methionine." ], [ "P18298-1", "2.5.1.6", "" ], [ "B1Q005-1", "2.3.1.-", "" ], [ "D4A4W5-1", "7.6.2.1", "ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2." ], [ "D4A4W5-1", "7.6.2.1", "" ], [ "P21932-1", "4.6.1.1", "ATP = 3',5'-cyclic AMP + diphosphate." ], [ "P21932-1", "4.6.1.1", "" ], [ "Q6AXR4-1", "3.2.1.52", "Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides." ], [ "Q6AXR4-1", "3.2.1.52", "" ], [ "Q05961-1", "2.7.7.84", "3 ATP = 5'-triphosphoadenylyl-(2'->5')-adenylyl-(2'->5')-adenosine + 2 diphosphate." ], [ "Q05961-1", "2.7.7.84", "" ], [ "P0C6P6-1", "3.4.24.85", "Cleaves several transcription factors that are type-2 transmembrane proteins within membrane-spanning domains. Known substrates include sterol regulatory element-binding protein (SREBP) -1, SREBP-2 and forms of the transcriptional activator ATF6. SREBP-2 is cleaved at the site 477-DRSRILL-|-CVLTFLCLSFNPLTSLLQWGGA-505. The residues Asn-Pro, 11 residues distal to the site of cleavage in the membrane-spanning domain, are important for cleavage by S2P endopeptidase. Replacement of either of these residues does not prevent cleavage, but there is no cleavage if both of these residues are replaced." ], [ "P0C6P6-1", "3.4.24.85", "" ], [ "D3ZDS3-1", "2.7.10.2", "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]." ], [ "D3ZDS3-1", "2.7.10.2", "" ], [ "Q6P7S1-1", "3.5.1.23", "an N-acylsphing-4-enine + H2O = a fatty acid + sphing-4-enine." ], [ "Q6P7S1-1", "3.5.1.23", "" ], [ "A0A0G2QC33-1", "3.4.22.-", "" ], [ "Q8CF82-1", "7.6.2.-", "" ], [ "D4A612-1", "2.3.1.199", "a very-long-chain acyl-CoA + H(+) + malonyl-CoA = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA." ], [ "D4A612-1", "2.3.1.199", "" ], [ "Q0HA29-1", "2.7.7.1", "ATP + beta-nicotinamide D-ribonucleotide + H(+) = diphosphate + NAD(+)." ], [ "Q0HA29-1", "2.7.7.18", "ATP + H(+) + nicotinate beta-D-ribonucleotide = deamido-NAD(+) + diphosphate." ], [ "Q0HA29-1", "2.7.7.1", "" ], [ "Q0HA29-1", "2.7.7.18", "" ], [ "Q6AXV9-1", "1.20.4.2", "2 glutathione + H(+) + methylarsonate = glutathione disulfide + H2O + methylarsonous acid." ], [ "Q6AXV9-1", "1.8.5.1", "2 glutathione + L-dehydroascorbate = glutathione disulfide + L-ascorbate." ], [ "Q6AXV9-1", "2.5.1.18", "glutathione + RX = a halide anion + an S-substituted glutathione + H(+)." ], [ "Q6AXV9-1", "1.20.4.2", "" ], [ "Q6AXV9-1", "2.5.1.18", "" ] ] }, "readme": "Name\n - Rat Protein Enzyme Annotation (UniProtKB)\n\nVersion\n - v-2.3.1\n\nCreated on\n - 2019-12-01T16:01:52.242488\n\nModified on\n - 2022-09-26T09:05:27.710226\n\nCreated by\n - Jeet Vora [jeetvora@gwu.edu], Robel Kahsay [rykahsay@gwu.edu], Karina Martinez [karinamartinez@gwu.edu], Jingyue Wu [jingyue.wu@email.gwu.edu]\n\nAuthors\n - Maria Martin [martin@ebi.ac.uk], Preethi Vasudev [pvasudev@ebi.ac.uk]\n\nChecksum\n - \n\nUsability Domain\n - The Rat Protein Enzyme Annotation (UniProtKB) dataset contains rat [taxid:10116] enzyme annotations for UniProtKB canonical accessions. The dataset contains ec numbers and enzyme activity that describes the enzymatic reactions. The dataset is derived form 2019-09 UniprotKB release. If you use this dataset please give proper attribution to UniProtKB and GlyGen\n\nDescription Domain\n Keywords\n - enzyme annotation\n - enzyme \n - UniProtKB\n - enzyme activity\n - EC number\n\n Pipeline Steps\n - Step-1: The script extracts the enzyme annotation triples from the triplestore for the UniProtKB canonical sequences and extracts as a dataset in a csv format\n\nExecution Domain\n Scripts - https://github.com/glygener/glygen-backend-integration/blob/master/dataset-maker/make-protein-dataset.py\n\n\n Software Prerequisites\n Name: Python\n Version: 2.7.5\n URI: https://www.python.org/download/releases/2.7.5/\n\nI/O Domain\n Input Subdomain\n Name: uniprot-proteome-rattus-norvegicus.nt\n URI: https:/data.glygen.org/ln2downloads/ebi/2023_10_30/uniprot-proteome-rattus-norvegicus.nt\n Output Subdomain\n Name: rat_protein_enzyme_annotation_uniprotkb.csv\n URI: https:/data.glygen.org/ln2releases/data/v-2.3.1/reviewed/rat_protein_enzyme_annotation_uniprotkb.csv\n Name: rat_protein_enzyme_annotation_uniprotkb.stat.csv\n URI: https:/data.glygen.org/ln2releases/data/v-2.3.1/reviewed/rat_protein_enzyme_annotation_uniprotkb.stat.csv\n\nFields\n Name: \"uniprotkb_canonical_ac\"\n Description: \"\"\n Unique Values: \"3445\"\n Name: \"enzyme_ec\"\n Description: \"Enzyme Commision number assigned to an enzyme by Nomenclature Committee of the International Union of Biochemistry and Molecular Biology (IUBMB)\"\n Unique Values: \"1366\"\n Name: \"enzyme_activity\"\n Description: \"The catalytic reaction activity of an enzyme in UniProtKB\"\n Unique Values: \"1227\"", "downloadurl": "/ln2data/releases/data/v-2.3.1/reviewed/rat_protein_enzyme_annotation_uniprotkb.csv" }