{
    "bcoid": "GLY_000125",
    "title": "Human UniProtKB Xref Reactome",
    "description": "The Human UniProtKB Xref Reactome contains human [taxid:9606] UniProtKB canonical accessions cross-referenced ...",
    "filename": "human_protein_xref_reactome.csv",
    "filetype": "csv",
    "categories": {
        "species": [
            "Homo sapiens"
        ],
        "molecule": [
            "Protein"
        ],
        "tag": [
            "Reactome cross-references"
        ],
        "file_type": [
            "csv"
        ],
        "status": [
            "Reviewed"
        ],
        "scope": [
            "internal"
        ]
    },
    "minitable": {
        "content": [
            [
                "Q96J66-1...",
                "protein_xref..."
            ],
            [
                "P40424-1...",
                "protein_xref..."
            ]
        ],
        "headers": [
            "uniprotkb_ca...",
            "xref_key..."
        ],
        "colwidth": [
            "40%",
            "20%"
        ]
    },
    "sampledata": {
        "type": "table",
        "data": [
            [
                {
                    "type": "string",
                    "label": "uniprotkb_canonical_ac"
                },
                {
                    "type": "string",
                    "label": "xref_key"
                },
                {
                    "type": "string",
                    "label": "xref_id"
                },
                {
                    "type": "string",
                    "label": "xref_label"
                }
            ],
            [
                "Q96J66-1",
                "protein_xref_reactome",
                "R-HSA-382556",
                "ABC-family proteins mediated transport"
            ],
            [
                "P40424-1",
                "protein_xref_reactome",
                "R-HSA-452723",
                "Transcriptional regulation of pluripotent stem cells"
            ],
            [
                "P40424-1",
                "protein_xref_reactome",
                "R-HSA-452723",
                "Transcriptional regulation of pluripotent stem cells"
            ],
            [
                "P40424-1",
                "protein_xref_reactome",
                "R-HSA-9013508",
                "NOTCH3 Intracellular Domain Regulates Transcription"
            ],
            [
                "P40424-1",
                "protein_xref_reactome",
                "R-HSA-5617472",
                "Activation of anterior HOX genes in hindbrain development during early embryogenesis"
            ],
            [
                "P40424-1",
                "protein_xref_reactome",
                "R-HSA-5617472",
                "Activation of anterior HOX genes in hindbrain development during early embryogenesis"
            ],
            [
                "P40424-1",
                "protein_xref_reactome",
                "R-HSA-5617472",
                "Activation of anterior HOX genes in hindbrain development during early embryogenesis"
            ],
            [
                "P40424-1",
                "protein_xref_reactome",
                "R-HSA-5617472",
                "Activation of anterior HOX genes in hindbrain development during early embryogenesis"
            ],
            [
                "P40424-1",
                "protein_xref_reactome",
                "R-HSA-5617472",
                "Activation of anterior HOX genes in hindbrain development during early embryogenesis"
            ],
            [
                "P40424-1",
                "protein_xref_reactome",
                "R-HSA-5617472",
                "Activation of anterior HOX genes in hindbrain development during early embryogenesis"
            ],
            [
                "P40424-1",
                "protein_xref_reactome",
                "R-HSA-5617472",
                "Activation of anterior HOX genes in hindbrain development during early embryogenesis"
            ],
            [
                "P40424-1",
                "protein_xref_reactome",
                "R-HSA-5617472",
                "Activation of anterior HOX genes in hindbrain development during early embryogenesis"
            ],
            [
                "P40429-1",
                "protein_xref_reactome",
                "R-HSA-72764",
                "Eukaryotic Translation Termination"
            ],
            [
                "P40429-1",
                "protein_xref_reactome",
                "R-HSA-72764",
                "Eukaryotic Translation Termination"
            ],
            [
                "P40429-1",
                "protein_xref_reactome",
                "R-HSA-156827",
                "L13a-mediated translational silencing of Ceruloplasmin expression"
            ],
            [
                "P40429-1",
                "protein_xref_reactome",
                "R-HSA-156827",
                "L13a-mediated translational silencing of Ceruloplasmin expression"
            ],
            [
                "P40429-1",
                "protein_xref_reactome",
                "R-HSA-156827",
                "L13a-mediated translational silencing of Ceruloplasmin expression"
            ],
            [
                "P40429-1",
                "protein_xref_reactome",
                "R-HSA-156902",
                "Peptide chain elongation"
            ],
            [
                "P40429-1",
                "protein_xref_reactome",
                "R-HSA-72764",
                "Eukaryotic Translation Termination"
            ],
            [
                "P40429-1",
                "protein_xref_reactome",
                "R-HSA-1799339",
                "SRP-dependent cotranslational protein targeting to membrane"
            ],
            [
                "P40429-1",
                "protein_xref_reactome",
                "R-HSA-1799339",
                "SRP-dependent cotranslational protein targeting to membrane"
            ],
            [
                "P40429-1",
                "protein_xref_reactome",
                "R-HSA-1799339",
                "SRP-dependent cotranslational protein targeting to membrane"
            ],
            [
                "P40429-1",
                "protein_xref_reactome",
                "R-HSA-1799339",
                "SRP-dependent cotranslational protein targeting to membrane"
            ],
            [
                "P40429-1",
                "protein_xref_reactome",
                "R-HSA-156902",
                "Peptide chain elongation"
            ],
            [
                "P40429-1",
                "protein_xref_reactome",
                "R-HSA-156902",
                "Peptide chain elongation"
            ],
            [
                "P40429-1",
                "protein_xref_reactome",
                "R-HSA-156902",
                "Peptide chain elongation"
            ],
            [
                "P40429-1",
                "protein_xref_reactome",
                "R-HSA-1799339",
                "SRP-dependent cotranslational protein targeting to membrane"
            ],
            [
                "P40429-1",
                "protein_xref_reactome",
                "R-HSA-192823",
                "Viral mRNA Translation"
            ],
            [
                "P40429-1",
                "protein_xref_reactome",
                "R-HSA-192823",
                "Viral mRNA Translation"
            ],
            [
                "P40429-1",
                "protein_xref_reactome",
                "R-HSA-2408557",
                "Selenocysteine synthesis"
            ],
            [
                "P40429-1",
                "protein_xref_reactome",
                "R-HSA-6791226",
                "Major pathway of rRNA processing in the nucleolus and cytosol"
            ],
            [
                "P40429-1",
                "protein_xref_reactome",
                "R-HSA-72689",
                "Formation of a pool of free 40S subunits"
            ],
            [
                "P40429-1",
                "protein_xref_reactome",
                "R-HSA-72706",
                "GTP hydrolysis and joining of the 60S ribosomal subunit"
            ],
            [
                "P40429-1",
                "protein_xref_reactome",
                "R-HSA-72706",
                "GTP hydrolysis and joining of the 60S ribosomal subunit"
            ],
            [
                "P40429-1",
                "protein_xref_reactome",
                "R-HSA-2408557",
                "Selenocysteine synthesis"
            ],
            [
                "P40429-1",
                "protein_xref_reactome",
                "R-HSA-9010553",
                "Regulation of expression of SLITs and ROBOs"
            ],
            [
                "P40429-1",
                "protein_xref_reactome",
                "R-HSA-9010553",
                "Regulation of expression of SLITs and ROBOs"
            ],
            [
                "P40429-1",
                "protein_xref_reactome",
                "R-HSA-975957",
                "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"
            ],
            [
                "P40429-1",
                "protein_xref_reactome",
                "R-HSA-975957",
                "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"
            ],
            [
                "P40429-1",
                "protein_xref_reactome",
                "R-HSA-975957",
                "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"
            ],
            [
                "P40429-1",
                "protein_xref_reactome",
                "R-HSA-975957",
                "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"
            ],
            [
                "P40429-1",
                "protein_xref_reactome",
                "R-HSA-975956",
                "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"
            ],
            [
                "P40429-1",
                "protein_xref_reactome",
                "R-HSA-9633012",
                "Response of EIF2AK4 (GCN2) to amino acid deficiency"
            ],
            [
                "P40429-1",
                "protein_xref_reactome",
                "R-HSA-9633012",
                "Response of EIF2AK4 (GCN2) to amino acid deficiency"
            ],
            [
                "P40429-1",
                "protein_xref_reactome",
                "R-HSA-9633012",
                "Response of EIF2AK4 (GCN2) to amino acid deficiency"
            ],
            [
                "P40429-1",
                "protein_xref_reactome",
                "R-HSA-9633012",
                "Response of EIF2AK4 (GCN2) to amino acid deficiency"
            ],
            [
                "Q9Y5S9-1",
                "protein_xref_reactome",
                "R-HSA-72163",
                "mRNA Splicing - Major Pathway"
            ],
            [
                "Q9Y5S9-1",
                "protein_xref_reactome",
                "R-HSA-72163",
                "mRNA Splicing - Major Pathway"
            ],
            [
                "Q9Y5S9-1",
                "protein_xref_reactome",
                "R-HSA-72163",
                "mRNA Splicing - Major Pathway"
            ],
            [
                "Q9Y5S9-1",
                "protein_xref_reactome",
                "R-HSA-72163",
                "mRNA Splicing - Major Pathway"
            ],
            [
                "Q9Y5S9-1",
                "protein_xref_reactome",
                "R-HSA-9010553",
                "Regulation of expression of SLITs and ROBOs"
            ],
            [
                "Q9Y5S9-1",
                "protein_xref_reactome",
                "R-HSA-9010553",
                "Regulation of expression of SLITs and ROBOs"
            ],
            [
                "Q9Y5S9-1",
                "protein_xref_reactome",
                "R-HSA-975957",
                "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"
            ],
            [
                "Q9Y5S9-1",
                "protein_xref_reactome",
                "R-HSA-975957",
                "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"
            ],
            [
                "Q9Y5S9-1",
                "protein_xref_reactome",
                "R-HSA-975957",
                "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"
            ],
            [
                "Q9Y5S9-1",
                "protein_xref_reactome",
                "R-HSA-975957",
                "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"
            ],
            [
                "Q9Y5S9-1",
                "protein_xref_reactome",
                "R-HSA-159236",
                "Transport of Mature mRNA derived from an Intron-Containing Transcript"
            ],
            [
                "Q9Y5S9-1",
                "protein_xref_reactome",
                "R-HSA-72187",
                "mRNA 3'-end processing"
            ],
            [
                "Q9Y5S9-1",
                "protein_xref_reactome",
                "R-HSA-73856",
                "RNA Polymerase II Transcription Termination"
            ],
            [
                "Q9Y5S9-1",
                "protein_xref_reactome",
                "R-HSA-72187",
                "mRNA 3'-end processing"
            ],
            [
                "Q9Y5S9-1",
                "protein_xref_reactome",
                "R-HSA-159236",
                "Transport of Mature mRNA derived from an Intron-Containing Transcript"
            ],
            [
                "Q9Y5S9-1",
                "protein_xref_reactome",
                "R-HSA-159236",
                "Transport of Mature mRNA derived from an Intron-Containing Transcript"
            ],
            [
                "Q9Y5S9-1",
                "protein_xref_reactome",
                "R-HSA-159236",
                "Transport of Mature mRNA derived from an Intron-Containing Transcript"
            ],
            [
                "Q9Y5S9-1",
                "protein_xref_reactome",
                "R-HSA-72187",
                "mRNA 3'-end processing"
            ],
            [
                "Q99519-1",
                "protein_xref_reactome",
                "R-HSA-9840310",
                "Glycosphingolipid catabolism"
            ],
            [
                "Q99519-1",
                "protein_xref_reactome",
                "R-HSA-4085001",
                "Sialic acid metabolism"
            ],
            [
                "Q99519-1",
                "protein_xref_reactome",
                "R-HSA-6798695",
                "Neutrophil degranulation"
            ],
            [
                "Q99519-1",
                "protein_xref_reactome",
                "R-HSA-4341670",
                "Defective NEU1 causes sialidosis"
            ],
            [
                "Q96RU7-1",
                "protein_xref_reactome",
                "R-HSA-165158",
                "Activation of AKT2"
            ],
            [
                "Q96RU7-1",
                "protein_xref_reactome",
                "R-HSA-1257604",
                "PIP3 activates AKT signaling"
            ],
            [
                "Q96RU7-1",
                "protein_xref_reactome",
                "R-HSA-1989781",
                "PPARA activates gene expression"
            ],
            [
                "Q96RU7-1",
                "protein_xref_reactome",
                "R-HSA-389357",
                "CD28 dependent PI3K/Akt signaling"
            ],
            [
                "Q96RU7-1",
                "protein_xref_reactome",
                "R-HSA-5218920",
                "VEGFR2 mediated vascular permeability"
            ],
            [
                "Q96RU7-1",
                "protein_xref_reactome",
                "R-HSA-199418",
                "Negative regulation of the PI3K/AKT network"
            ],
            [
                "Q96RU7-1",
                "protein_xref_reactome",
                "R-HSA-9633012",
                "Response of EIF2AK4 (GCN2) to amino acid deficiency"
            ],
            [
                "Q96RU7-1",
                "protein_xref_reactome",
                "R-HSA-9648895",
                "Response of EIF2AK1 (HRI) to heme deficiency"
            ],
            [
                "Q96RU7-1",
                "protein_xref_reactome",
                "R-HSA-9648895",
                "Response of EIF2AK1 (HRI) to heme deficiency"
            ],
            [
                "Q96RU3-1",
                "protein_xref_reactome",
                "R-HSA-8856828",
                "Clathrin-mediated endocytosis"
            ],
            [
                "Q96RU3-1",
                "protein_xref_reactome",
                "R-HSA-8856828",
                "Clathrin-mediated endocytosis"
            ],
            [
                "Q96RU3-1",
                "protein_xref_reactome",
                "R-HSA-8856828",
                "Clathrin-mediated endocytosis"
            ],
            [
                "Q96RU3-1",
                "protein_xref_reactome",
                "R-HSA-8856828",
                "Clathrin-mediated endocytosis"
            ],
            [
                "Q96RU3-1",
                "protein_xref_reactome",
                "R-HSA-8856828",
                "Clathrin-mediated endocytosis"
            ],
            [
                "Q96RU3-1",
                "protein_xref_reactome",
                "R-HSA-8856828",
                "Clathrin-mediated endocytosis"
            ],
            [
                "Q96RU3-1",
                "protein_xref_reactome",
                "R-HSA-8856828",
                "Clathrin-mediated endocytosis"
            ]
        ]
    },
    "readme": "Name\n   - Human UniProtKB Xref Reactome\n\nVersion\n   - v-2.3.1\n\nCreated on\n  - 2019-03-15T16:14:06.456984\n\nModified on\n   - 2022-09-26T08:56:48.490955\n\nCreated by\n   - Jeet Vora [jeetvora@gwu.edu], Robel Kahsay [rykahsay@gwu.edu], Karina Martinez [karinamartinez@gwu.edu], Jingyue Wu [jingyue.wu@email.gwu.edu]\n\nAuthors\n   - Maria Martin [martin@ebi.ac.uk], Preethi Vasudev [pvasudev@ebi.ac.uk]\n\nChecksum\n   - \n\nUsability Domain\n   - The Human UniProtKB Xref Reactome contains human [taxid:9606] UniProtKB canonical accessions cross-referenced to Reactome database accessions/identifiers. The dataset is derived from 2019-09 UniProtKB release. If you use this dataset please provide proper attribution to EMBL-EBI-UniProtKB and GlyGen\n   - REACTOME is an open-source, open access, manually curated and peer-reviewed pathway database. \n\nDescription Domain\n   Keywords\n   - pathways\n   - reactions\n   - REACTOME\n   - cross-reference\n\n   Pipeline Steps\n   - Step-1: The script loads the UniProtKB canonical accessions that are cross-referenced to REACTOME database accessions/identifiers from the triplestore containing triples from nt file and extracts the data as a csv dataset. \n\nExecution Domain\n   Scripts   - https://github.com/glygener/glygen-backend-integration/blob/master/dataset-maker/make-protein-dataset.py\n\n\n   Software Prerequisites\n      Name: Python\n      Version: 2.7.5\n      URI: https://www.python.org/download/releases/2.7.5/\n\nI/O Domain\n   Input Subdomain\n      Name: uniprot-proteome-homo-sapiens.nt\n      URI: https:/data.glygen.org/ln2downloads/ebi/2023_10_30/uniprot-proteome-homo-sapiens.nt\n   Output Subdomain\n      Name: human_protein_xref_reactome.csv\n      URI: https:/data.glygen.org/ln2releases/data/v-2.3.1/reviewed/human_protein_xref_reactome.csv\n      Name: human_protein_xref_reactome.stat.csv\n      URI: https:/data.glygen.org/ln2releases/data/v-2.3.1/reviewed/human_protein_xref_reactome.stat.csv\n\nFields\n      Name: \"uniprotkb_canonical_ac\"\n     Description: \"\"\n      Unique Values: \"11017\"\n      Name: \"xref_key\"\n     Description: \"Source key associated to the  xref_id\"\n      Unique Values: \"1\"\n      Name: \"xref_id\"\n     Description: \"ID of the X-ref\"\n      Unique Values: \"2118\"\n      Name: \"xref_label\"\n     Description: \"Label/Name associated with x-ref\"\n      Unique Values: \"2105\"",
    "downloadurl": "/ln2data/releases/data/v-2.3.1/reviewed/human_protein_xref_reactome.csv"
}