{
    "assessed_biomarker_entity": "Epidermal growth factor receptor protein (EGFR)",
    "assessed_entity_type": "protein",
    "components": {
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            {
                "accession": "P00533-1",
                "name": "Epidermal growth factor receptor",
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                        "url": "https://data.glygen.org/GLY_000625"
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        ],
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    "instances": [
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            "notes": "EDRN biomarker|EGFR is also associated with various other cancers, most notably due to mutations that result in increased protein expression|Also a predictive biomarker|Increased expression of Epidermal growth factor receptor (EGFR)|Alternate LOINC ID:14050-9|Epidermal growth factor receptor [Moles/mass] in tissue",
            "literature_evidence": "The high expression of EGFR can be used to predict the severity of IBC, as well as the candidate biomarkers of metastasis, and it may also be associated with poor prognosis of IBC patients. [PMID:30431376]",
            "loinc_code": "13659-8",
            "tissue": {
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                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:1612",
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                    "description": "A thoracic cancer that originates in the mammary gland."
                },
                "synonyms": [
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                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:1612",
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                        "description": ""
                    },
                    {
                        "id": "DOID:1612",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:1612",
                        "name": "malignant neoplasm of breast",
                        "description": ""
                    },
                    {
                        "id": "DOID:1612",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:1612",
                        "name": "malignant tumor of the breast",
                        "description": ""
                    },
                    {
                        "id": "DOID:1612",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:1612",
                        "name": "mammary cancer",
                        "description": ""
                    },
                    {
                        "id": "DOID:1612",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:1612",
                        "name": "mammary tumor",
                        "description": ""
                    },
                    {
                        "id": "DOID:1612",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:1612",
                        "name": "primary breast cancer",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0016419",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                        "name": "hereditary breast carcinoma",
                        "description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma."
                    },
                    {
                        "id": "MONDO:0016419",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                        "name": "breast cancer susceptibility, autosomal dominant, somatic mutation",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0016419",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                        "name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0016419",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                        "name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0016419",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                        "name": "breast cancer, lobular, somatic",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0016419",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                        "name": "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0016419",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                        "name": "breast cancer, protection against, autosomal dominant, somatic mutation",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0016419",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                        "name": "breast cancer, somatic",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0016419",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                        "name": "breast cancer, susceptibility to, autosomal dominant, somatic mutation",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0016419",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                        "name": "familial breast cancer",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0016419",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                        "name": "familial breast carcinoma",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0016419",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                        "name": "familial cancer of breast",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0016419",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0016419",
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                        "description": ""
                    },
                    {
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                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0016419",
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                        "description": ""
                    },
                    {
                        "id": "MONDO:0016419",
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                        "url": "https://monarchinitiative.org/disease/MONDO:0016419",
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                        "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                        "name": "breast cancer, familial",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0016419",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                        "name": "breast cancer, familial Male",
                        "description": ""
                    },
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                        "id": "MIM:114480",
                        "resource": "MIM",
                        "url": "https://www.omim.org/entry/114480",
                        "name": "Breast cancer",
                        "description": "Breast cancer"
                    }
                ]
            },
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                    "database": "GlyGen",
                    "url": "https://data.glygen.org/GLY_000625"
                },
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                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/30431376"
                }
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            "notes": "FDA and EDRN biomarker|Overexpression of EGFR|Alternate LOINC ID:14050-9|Epidermal growth factor receptor [Moles/mass] in tissue",
            "literature_evidence": "One hundred and forty cases (27.4%) showed EGFR overexpression by IHC. EGFR overexpression was associated with older age (P = 0.001), moderately or poorly differentiated histology (P = 0.001) and higher stage disease (P = 0.046). [PMID:18397279]",
            "loinc_code": "13659-8",
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                "namespace": "UBERON",
                "id": "0000945",
                "url": "http://purl.obolibrary.org/obo/UBERON_0000945"
            },
            "disease": {
                "disease_id": "DOID:10534",
                "recommended_name": {
                    "id": "DOID:10534",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:10534",
                    "name": "stomach cancer",
                    "description": "A gastrointestinal system cancer that is located_in the stomach."
                },
                "synonyms": [
                    {
                        "id": "DOID:10534",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:10534",
                        "name": "gastric cancer",
                        "description": ""
                    },
                    {
                        "id": "DOID:10534",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:10534",
                        "name": "gastric neoplasm",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0001056",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                        "name": "gastric cancer",
                        "description": "A primary or metastatic malignant neoplasm involving the stomach."
                    },
                    {
                        "id": "MONDO:0001056",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                        "name": "gastric neoplasm",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0001056",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                        "name": "Ca lesser curvature - stomach",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0001056",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                        "name": "cancer of stomach",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0001056",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                        "name": "gastric cancer",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0001056",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                        "name": "gastric cancer risk after h. pylori infection",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0001056",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                        "name": "gastric cancer, somatic",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0001056",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                        "name": "malignant gastric neoplasm",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0001056",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                        "name": "malignant gastric tumor",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0001056",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                        "name": "malignant gastric tumour",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0001056",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                        "name": "malignant neoplasm of lesser curve of stomach",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0001056",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                        "name": "malignant neoplasm of stomach",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0001056",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                        "name": "malignant neoplasm of the stomach",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0001056",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                        "name": "malignant stomach neoplasm",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0001056",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                        "name": "malignant tumor of body of stomach",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0001056",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                        "name": "malignant tumor of greater curve of stomach",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0001056",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                        "name": "malignant tumor of lesser curve of stomach",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0001056",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                        "name": "malignant tumor of stomach",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0001056",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                        "name": "malignant tumor of the stomach",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0001056",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                        "name": "malignant tumour of body of stomach",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0001056",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                        "name": "malignant tumour of greater curve of stomach",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0001056",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0001056",
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                    },
                    {
                        "id": "MONDO:0001056",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0001056",
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                    },
                    {
                        "id": "MONDO:0001056",
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                    },
                    {
                        "id": "MONDO:0001056",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                        "name": "stomach cancer",
                        "description": ""
                    },
                    {
                        "id": "MONDO:0001056",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0001056",
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                    },
                    {
                        "id": "MONDO:0001056",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0001056",
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                    {
                        "id": "MONDO:0001056",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0001056",
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                    },
                    {
                        "id": "MONDO:0001056",
                        "resource": "MONDO",
                        "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                        "name": "gastric cancer, intestinal",
                        "description": ""
                    },
                    {
                        "id": "MIM:613659",
                        "resource": "MIM",
                        "url": "https://www.omim.org/entry/613659",
                        "name": "Gastric cancer",
                        "description": "Gastric cancer"
                    }
                ]
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                    "id": "GLY_000625",
                    "database": "GlyGen",
                    "url": "https://data.glygen.org/GLY_000625"
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                    "id": "18397279",
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            "title": "EGFR in gastric carcinomas: prognostic significance of protein overexpression and high gene copy number.",
            "journal": "Histopathology",
            "authors": "Kim MA, Lee HS, Lee HE, Jeon YK, Yang HK, Kim WH",
            "date": "2008",
            "reference": [
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                    "id": "18397279",
                    "url": "https://glygen.org/publication/PubMed/18397279"
                }
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                    "database": "GlyGen",
                    "url": "https://data.glygen.org/GLY_000625"
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            ]
        },
        {
            "title": "Relationship of Epidermal Growth Factor Receptor Expression with Clinical Symptoms and Metastasis of Invasive Breast Cancer.",
            "journal": "Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research",
            "authors": "Han L, Li L, Wang N, Xiong Y, Li Y, Gu Y",
            "date": "2018",
            "reference": [
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