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            "literature_evidence": "By using biomarker discovery analysis, we found that expression of a combination of six genes, including TNFRSF1B (CD120b) and FOXP3, was significantly different between Tregs from subjects with new-onset T1D and control subjects, resulting in a sensitive (mean \u00b1 SD 0.86 \u00b1 0.14) and specific (0.78 \u00b1 0.18) biomarker algorithm. Thus, although the proportion of Tregs in peripheral blood is similar between children with T1D and control subjects, significant changes in gene expression can be detected early in disease process. Lower expression of FOXP3, TNFRSF1B (CD120b),  TMEM23 (SGMS1), ZNF532, ANK3, and increased LRRC32 (GARP). [PMID:26786322]",
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        {
            "title": "A Regulatory T-Cell Gene Signature Is a Specific and Sensitive Biomarker to Identify Children With New-Onset Type 1 Diabetes.",
            "journal": "Diabetes",
            "authors": "Pesenacker Anne M, Wang Adele Y, Singh Amrit, Gillies Jana, Kim Youngwoong, Piccirillo Ciriaco A, Nguyen Duc, Haining W Nicholas, Tebbutt Scott J, Panagiotopoulos Constadina, Levings Megan K",
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